TWAS hub - HOOK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.126	0.054	0.00700	0.039	NA	-0.005	NA	0.000	0.0019	NA	0.8900	NA	3.3e-01
2	GTEx	Spleen	0.501	0.103	0.00019	0.066	NA	0.052	NA	0.227	0.0092	NA	0.0180	NA	1.6e-06
3	GTEx	Whole Blood	0.068	0.026	0.00310	0.009	NA	0.018	NA	0.016	0.0410	NA	0.0081	NA	1.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Red Count	31.7	306.1	566.4	23.8	12.6	13.9
Medication: Metformin	10.6	14.9	20.6	4.5	2.5	4.2
Diabetes (mother)	10.4	13.3	18.9	4.3	1.5	4.3
Diabetes (self-reported)	10.4	16.0	20.3	4.5	2.7	4.5
Type 2 Diabetes (T2D) (2018)	8.5	16.0	20.6	4.4	2.8	4.5
Smoking status: Previous	8.1	12.2	20.1	-4.5	-3.1	-2.7
Alcohol drinker status: Previous	6.6	7.5	10.1	-3.2	-2.6	-2.3
Diabetes diagnosed by doctor	6.4	10.5	15.9	3.6	1.7	4.0
Mouth/teeth dental problems: Dentures	5.2	8.8	13.6	1.8	3.1	3.7
Age at last live birth	4.8	7.0	13.5	-1.8	-2.1	-3.7
Medication: Levothyroxine sodium	4.7	7.9	15.7	-2.0	-4.0	-2.0
Past tobacco smoking	4.2	7.7	12.8	3.6	2.6	1.9
Age when periods started (menarche)	3.9	9.4	21.2	-4.6	-1.6	-2.1
Hair/balding pattern: Pattern 3	3.8	5.6	7.4	2.0	2.3	2.7
Medication: Gliclazide	3.8	4.3	5.0	2.0	2.2	2.0
Family relationship satisfaction	3.7	4.5	6.6	2.3	-1.2	2.6
Basal cell carcinoma (self-reported)	3.5	4.2	5.1	-1.9	-2.3	-2.0
Loneliness, isolation	3.3	4.6	7.9	1.5	1.9	2.8
Mouth/teeth dental problems	3.0	4.6	9.6	-1.1	-3.1	-1.7
Breast Cancer	2.9	7.1	15.9	4.0	0.9	2.1
BMI	2.9	17.0	25.0	3.4	3.8	5.0
Hayfever/allergic rhinitis (self-reported)	2.9	3.9	9.7	1.2	3.1	0.8
Impedance of arm (left)	2.9	13.4	17.8	-4.2	-3.4	-3.3
Age at First Birth	2.8	4.0	5.9	-1.5	-2.0	-2.4
Hand grip strength (left)	2.7	7.2	10.4	-2.5	-2.2	-3.2
Impedance of arm (right)	2.6	12.3	17.1	-4.1	-3.1	-3.2
Hypothyroidism/myxoedema (self-reported)	2.6	5.1	7.7	-1.9	-2.8	-2.0
Leg fat percentage (right)	2.6	9.4	18.4	1.8	2.5	4.3
Exposure to tobacco smoke outside home	2.6	3.5	6.8	2.6	0.8	1.7
Age at first live birth	2.6	4.6	9.0	-1.1	-1.9	-3.0
Leg fat percentage (left)	2.6	9.3	18.1	2.0	2.4	4.3
Mean Putamen Volume	2.5	2.9	7.9	-0.4	-0.8	-2.8
Hip circumference	2.5	10.7	14.3	1.9	3.8	3.8
Breastfed as a baby	2.5	3.1	4.3	-1.5	-1.7	-2.1
Osteoporosis (self-reported)	2.5	3.1	4.7	0.1	2.1	2.2
Ever had hysterectomy (womb removed)	2.4	2.7	3.5	1.9	1.5	1.4
Body mass index (BMI)	2.4	10.1	13.6	2.4	3.3	3.7
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	5.2	-2.3	-1.0	-1.2
Medication: Blood pressure	2.4	4.6	5.7	1.8	2.4	2.3
Chronic bronchitis/emphysema (mother)	2.3	2.7	4.9	1.4	1.2	2.2
Health satisfaction	2.3	3.0	6.1	1.0	2.5	1.4
Financial situation satisfaction	2.3	2.9	4.7	1.4	1.4	2.2
Pain experienced in last month	2.3	3.9	6.3	-1.6	-2.5	-1.6
Schizophrenia (2014)	2.2	4.9	10.9	-2.0	-3.3	0.0
Lung cancer (father)	2.2	2.5	6.4	1.1	2.5	0.2
Illness, injury, bereavement, stress in last 2 years	2.2	2.6	5.0	-1.6	-0.6	-2.2
Supplements: Calcium	2.2	2.4	3.3	-1.8	-0.9	-1.7
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	4.4	1.1	1.1	2.1
Diabetes (father)	2.1	2.6	3.8	0.9	2.0	1.8
Length of working week for main job	2.1	2.3	5.8	0.8	2.4	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	3.3	-1.8	-1.3	-1.5
Average weekly champagne plus white wine intake	2.1	2.8	3.6	1.9	1.2	1.9
Bipolar Disorder or Schizophrenia	2.0	4.8	11.3	-1.7	-3.4	0.6
Alcohol intake frequency.	2.0	4.6	6.3	1.1	2.5	2.5
Bipolar Disorder (2018)	1.9	2.9	6.7	-1.4	-2.6	0.5
Relative age voice broke	1.9	2.9	5.0	-2.2	-1.5	-1.1
Nervous feelings	1.9	3.5	5.2	-2.3	-2.1	-0.9
Medication: Ramipril	1.9	2.5	5.3	1.3	0.7	2.3
Ever smoked	1.9	3.4	6.3	-2.5	-1.7	-1.0
Illnesses of mother	1.8	2.3	3.6	-1.9	0.2	-1.8
Glaucoma (self-reported)	1.8	2.1	2.4	-1.6	-1.3	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	3.8	-1.9	-1.7	-0.3
Medication: Omeprazole	1.8	2.1	4.2	-2.0	-0.6	-1.3
Leg pain on walking	1.8	2.2	3.3	-1.2	1.8	-1.3
Illnesses of siblings: Diabetes	1.8	2.2	3.9	1.3	1.0	2.0
Heart disease (siblings)	1.8	2.3	4.0	2.0	1.1	1.2
Crohns Disease (2012)	1.6	2.6	3.5	1.9	1.8	0.9
Hair/balding pattern: Pattern 2	1.6	2.0	5.2	-0.5	-0.8	-2.3
Neck or shoulder pain in last month	1.6	2.3	2.9	1.7	1.5	1.3
Migraine (self-reported)	1.6	2.0	2.4	-1.5	-1.2	-1.6
Eye problems/disorders: Cataract	1.6	1.8	4.1	2.0	0.7	1.0
Prostate Cancer	1.5	2.0	2.2	-1.5	-1.4	-1.3
Height	1.5	28.1	53.6	-7.3	1.0	-5.5
Chronotype (morning person)	1.5	3.4	5.6	-1.4	-1.6	-2.4
Supplements: Zinc	1.5	1.6	3.6	-0.8	-0.8	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	8.1	2.9	0.4	1.5
Stomach or abdominal pain in last month	1.5	1.8	2.8	1.3	1.7	1.0
Supplements: Glucosamine	1.5	2.0	3.5	-1.3	-0.9	-1.9
Gout (self-reported)	1.5	2.1	3.8	0.2	2.0	1.6
Leg fat mass (right)	1.5	5.9	9.9	1.1	2.6	3.1
Leg fat mass (left)	1.5	5.8	9.4	1.2	2.5	3.1
Schizophrenia (2018)	1.4	2.9	7.3	-1.1	-2.7	0.4
LDL Cholesterol	1.4	2.2	4.4	-0.8	-2.1	1.2
Blood Platelet Count	1.4	16.7	39.3	-6.3	-3.2	-0.7
Number of incorrect matches in round	1.4	2.4	4.8	2.2	-1.3	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.1	-1.8	-1.2	-1.3
Number of full brothers	1.4	1.7	3.1	1.4	-0.0	1.8
Illnesses of father: Heart disease	1.4	1.9	3.1	1.4	0.7	1.8
Mineral and other dietary supplements	1.4	1.9	3.7	1.3	-0.4	1.9
Impedance of whole body	1.4	7.0	8.4	-2.9	-2.9	-2.1
Alzheimer’s Disease (in mother)	1.3	1.5	4.2	-0.6	-2.0	0.1
Alzheimer’s Disease (in father)	1.3	1.4	3.6	-1.9	-0.6	0.3
HbA1C	1.3	1.4	4.3	2.1	0.1	0.0
Cardiovascular Disease	1.3	4.1	8.9	1.7	0.7	3.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	2.8	0.9	0.7	-1.7
Medication: Simvastatin	1.3	1.9	2.2	1.2	1.5	1.5
Illnesses of siblings	1.3	1.8	4.2	-1.1	-0.4	-2.1
Suffer from ‘nerves’	1.3	2.0	5.9	-0.4	-2.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	5.4	-1.5	0.6	-2.3
Qualifications: nursing, teaching	1.3	2.0	3.6	0.1	-1.9	-1.5
Average weekly beer plus cider intake	1.3	1.9	4.7	-0.8	-0.7	-2.2
Waist Hip Ratio (WHR)	1.2	5.2	9.7	-3.1	-2.1	-1.2
Allergy or Eczema	1.2	3.1	3.4	1.7	1.8	1.8
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.2	1.8	0.4	1.1
High blood pressure (mother)	1.2	1.7	2.8	1.7	0.9	1.2
Arm fat mass (right)	1.2	4.9	7.0	0.9	2.6	2.6
Standing height	1.2	11.7	22.1	-4.7	0.2	-3.6
Number of children fathered	1.2	1.3	2.3	-1.1	-1.5	-0.6
Arm fat mass (left)	1.2	5.0	7.0	1.0	2.6	2.6
Wears glasses or contact lenses	1.2	1.4	2.7	1.2	-1.6	-0.2
Hearing aid user	1.2	1.4	2.9	1.1	0.2	1.7
Number of operations (self-reported)	1.2	1.7	5.1	0.2	2.3	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.5	-1.6	-0.5	-1.4
Systolic blood pressure, automated reading	1.1	3.1	8.0	1.0	0.4	2.8
Fed-up feelings	1.1	2.0	4.5	0.9	0.9	2.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.2	-0.1	2.1	-0.1
Medication for cholesterol	1.1	1.7	2.7	-1.6	-0.9	-1.2
Arm predicted mass (left)	1.1	5.4	13.2	0.9	3.6	1.5
Systolic Blood Pressure	1.0	4.9	9.9	1.9	1.1	3.1
Hypothyroidism (self reported)	1.0	2.3	4.0	-2.0	-1.3	-1.2
Impedance of leg (right)	1.0	4.7	6.9	-2.2	-2.6	-1.5
Waist circumference	1.0	3.8	6.9	0.0	2.1	2.6
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	5.8	2.4	0.4	0.9
Weight	1.0	4.7	10.2	0.3	3.2	1.9
Body fat percentage	1.0	4.1	9.2	0.6	1.7	3.0
Medication: Allopurinol	1.0	1.3	2.2	0.2	1.3	1.5
Knee pain experienced in last month	1.0	1.5	4.2	-2.0	-0.3	-0.5
Cholesterol lowering medication	1.0	1.5	2.1	1.2	1.5	1.0
Blood Eosinophil Count	0.9	6.6	14.2	2.1	1.1	3.8
Medication for hormone replacement therapy	0.9	1.0	1.9	-0.3	-1.0	-1.4
Current tobacco smoking	0.9	1.4	1.7	1.2	1.1	1.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.5	1.1	1.2	0.7
Impedance of leg (left)	0.9	4.3	7.4	-1.8	-2.7	-1.6
Forced vital capacity (FVC)	0.9	3.4	5.7	-2.1	0.2	-2.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.4	1.1	0.7	1.2
Had major operations	0.9	1.1	2.2	0.7	1.5	0.7
Arm fat-free mass (left)	0.9	4.4	11.0	0.7	3.3	1.3
Myopia	0.9	1.4	2.0	1.4	-0.6	1.3
Heel T-Score	0.8	6.1	11.1	3.3	2.6	0.2
Trunk fat percentage	0.8	3.3	7.3	0.1	1.6	2.7
Trunk fat mass	0.8	3.6	6.4	0.0	2.1	2.5
Had menopause	0.8	0.9	1.9	0.6	0.7	1.4
Arm fat percentage (right)	0.8	3.1	5.9	0.9	1.6	2.4
Birth weight of first child	0.8	1.4	2.8	-1.2	-1.7	0.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	1.8	1.3	1.4	0.6
Medication: Amlodipine	0.8	1.2	2.7	-0.9	0.0	1.6
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.1	-0.9	-1.4	0.1
Arm fat-free mass (right)	0.8	4.0	9.7	0.7	3.1	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.6	-1.3	-0.6	-0.9
Medication: Blood pressure	0.8	1.4	2.9	-1.1	-1.7	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.9	-1.0	-1.4	-0.2
Whole body fat mass	0.8	3.3	5.7	0.3	2.0	2.4
Arm predicted mass (right)	0.8	4.0	10.1	0.7	3.2	1.2
Arm fat percentage (left)	0.8	3.2	6.4	0.9	1.6	2.5
Smoking status: Current	0.8	1.2	1.4	1.0	1.0	1.2
Guilty feelings	0.8	1.2	2.0	-1.2	-1.4	-0.1
Eye problems/disorders: Glaucoma	0.8	1.0	1.8	-1.4	-0.4	-1.0
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.7	-0.8	0.8	-1.3
Unable to work because of sickness or disability	0.8	1.1	1.7	-1.3	-0.8	0.9
Smoking Status	0.7	1.7	3.3	-1.8	-1.2	-0.7
Medication: Co-codamol	0.7	0.8	1.6	0.7	1.3	0.6
Taking other prescription medications	0.7	1.1	2.1	-1.0	-0.3	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.5	0.8	-0.1	1.6
Financial difficulties in last 2 years	0.7	0.9	1.5	1.1	-0.1	1.2
Time employed in main current job	0.7	0.8	1.3	0.5	-1.0	-1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	4.0	-2.0	0.6	-1.7
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.6	0.2	-2.1	-0.1
Tense / ‘highly strung’	0.7	1.2	3.4	0.3	-0.3	1.8
Hair/balding pattern: Pattern 4	0.7	1.6	3.0	1.1	0.8	1.7
High blood pressure (siblings)	0.7	1.1	3.1	0.4	0.1	1.8
Forced vital capacity (FVC), Best measure	0.7	2.6	2.8	-1.6	1.5	-1.7
Medication: Seretide 50 evohaler	0.7	0.8	1.2	-1.1	-1.1	0.1
Comparative height size at age 10	0.7	4.1	8.3	-2.0	-0.3	-2.9
Number of full sisters	0.7	0.8	1.5	0.9	1.2	0.4
Medication: Aspirin	0.7	0.9	2.1	-0.7	-1.4	-0.4
Friendships satisfaction	0.7	0.9	1.1	1.1	-0.8	0.9
Medication: Aspirin	0.7	0.9	2.4	-0.4	-1.5	-0.5
Alzheimer’s Disease (including proxy)	0.6	0.8	1.3	-1.0	-1.1	0.4
Rheumatoid Arthritis	0.6	0.8	1.9	0.7	0.1	1.4
Leg fat-free mass (left)	0.6	3.4	9.9	-0.3	3.1	0.5
Average weekly fortified wine intake	0.6	0.7	1.2	0.4	1.1	-0.9
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.5	1.1	1.6	0.6
Leg predicted mass (left)	0.6	3.4	9.8	-0.2	3.1	0.4
Had other major operations	0.6	0.8	2.0	0.4	1.4	0.4
Worrier / anxious feelings	0.6	1.1	2.5	-0.5	-0.8	-1.6
Number of live births	0.6	0.8	1.3	-1.1	-0.4	-1.0
Happiness	0.6	0.7	1.3	0.2	-0.8	1.1
Prospective memory result	0.6	0.8	1.2	-0.5	-1.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.2	-1.3	1.8	-0.8
Loud music exposure frequency	0.6	0.7	1.9	-1.4	0.3	0.3
Emphysema/chronic bronchitis	0.6	0.6	1.7	-1.3	-0.5	0.0
Pulse rate, automated reading	0.6	1.9	3.6	1.9	-1.0	1.0
Chest pain or discomfort	0.6	0.9	1.8	0.7	0.5	1.4
Hypertension (Self-reported)	0.6	1.6	4.3	0.6	-0.5	2.1
Whole body fat-free mass	0.6	3.4	10.0	-0.2	3.2	0.1
Leg fat-free mass (right)	0.6	3.0	9.1	-0.2	3.0	0.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	-0.4	-1.1	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.7	-0.8	0.9	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.1	-0.9	1.0	-0.4
Osteoarthritis (self-reported)	0.6	0.8	1.8	-0.4	1.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	1.7	-0.9	1.3	-1.3
Whole body water mass	0.6	3.5	10.6	-0.1	3.3	0.2
Leg predicted mass (right)	0.6	3.0	8.8	-0.2	3.0	0.1
Basal metabolic rate	0.6	3.5	10.3	-0.1	3.2	0.6
Fractured/broken bones in last 5 years	0.6	0.7	1.8	1.3	0.6	0.3
Depressed Affect (Nagel 2018)	0.5	1.1	2.1	-0.0	1.0	1.5
Ulcerative Colitis (UC)	0.5	1.0	1.5	-1.1	-0.5	-1.2
Fasting Glucose	0.5	0.6	1.0	-1.0	0.8	-0.2
Neuroticism (2016)	0.5	0.7	1.6	1.2	-0.5	0.4
Triglycerides	0.5	0.8	1.3	-0.0	-1.2	-1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	0.0	0.8	1.0
Ulcerative Colitis	0.5	0.8	2.0	0.4	-1.4	0.4
Blood White Count	0.5	3.5	6.6	-1.9	-2.6	0.1
Respiratory disease	0.5	1.1	1.9	1.1	0.6	1.4
Sensitivity / hurt feelings	0.5	0.9	1.1	0.9	1.0	1.0
Qualifications: CSEs or equivalent	0.5	0.7	1.5	0.6	1.2	-0.6
Medication: Atenolol	0.5	0.7	1.3	0.6	0.5	1.2
Hearing difficulty/problems with background noise	0.5	0.8	1.8	0.6	0.3	1.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	0.9	-0.1	1.1
Trunk fat-free mass	0.5	2.9	8.3	-0.4	2.9	-0.3
Falls in the last year	0.5	0.7	1.0	-0.9	0.5	1.0
Medication: Lansoprazole	0.5	0.5	1.3	-1.2	-0.5	-0.2
Trunk predicted mass	0.5	2.8	8.2	-0.4	2.9	-0.3
Exposure to tobacco smoke at home	0.5	0.6	1.3	1.1	-0.7	-0.2
Peak expiratory flow (PEF)	0.5	1.1	3.3	-1.8	0.3	-0.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	-0.6	-0.7	-1.0
Shortness of breath walking on level ground	0.5	0.6	0.7	0.7	0.8	0.8
Breast cancer (self-reported)	0.5	0.6	1.0	-1.0	-0.1	-0.9
Commuting to job workplace: Public transport	0.5	0.6	1.1	0.8	1.0	-0.1
Risk taking	0.5	0.7	2.1	0.1	-0.1	1.4
Relative age of first facial hair	0.4	0.8	1.5	-0.9	-1.2	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	-0.4	0.7	-0.9
Severe depression (siblings)	0.4	0.4	1.2	1.1	-0.3	-0.1
High blood pressure	0.4	1.0	2.7	0.3	-0.5	1.6
Pulse wave peak to peak time	0.4	0.5	0.6	-0.8	-0.6	-0.8
Qualifications: College or University degree	0.4	1.1	2.9	0.3	-1.7	-0.6
Medication: Ibuprofen	0.4	0.5	1.3	-0.4	0.3	-1.2
Overall health rating	0.4	0.8	1.5	-0.2	1.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.6	-0.8	-0.5	-0.8
Long-standing illness, disability or infirmity	0.4	0.5	1.6	0.0	0.1	1.3
Ever had bowel cancer screening	0.4	0.5	1.3	0.3	1.2	0.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	0.6	1.0	0.5
Medication: Bendroflumethiazide	0.4	0.6	1.3	-0.8	-1.1	0.0
Illnesses of father: High blood pressure	0.4	0.5	0.8	0.9	0.7	-0.0
Commuting to job workplace: Cycle	0.4	0.4	0.5	-0.6	-0.7	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.5	-0.7	0.4	-1.6
Depression (Nagel 2018)	0.3	0.5	1.4	-0.2	0.0	1.2
Irritable Bowel Disease (IBD)	0.3	0.7	1.8	-1.3	-0.2	-0.5
Reaction Time	0.3	0.7	1.8	0.1	1.4	0.3
Ovarian Cancer	0.3	0.4	0.7	0.6	0.3	0.9
Neuroticism	0.3	0.8	1.5	0.9	0.1	1.2
Number of treatments/medications taken	0.3	0.6	1.3	-0.7	0.1	-1.1
Hand grip strength (right)	0.3	0.7	1.4	-0.8	-0.4	-1.2
Multivitamins +/- minerals	0.3	0.4	0.6	-0.7	-0.1	-0.8
Sitting height	0.3	1.9	5.5	-0.4	2.3	-0.3
Qualifications: None of the above	0.3	0.7	1.8	-0.3	0.5	1.3
Pain all over the body in last month	0.3	0.3	0.7	-0.4	0.4	-0.8
Fluid intelligence score	0.3	0.7	1.3	0.3	0.9	1.2
Father’s age at death	0.3	0.4	0.8	0.3	-0.9	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.6	0.8	-0.3
Medication: Cholesterol lowering	0.3	0.5	0.9	-1.0	-0.4	-0.6
Birth weight	0.3	0.7	1.8	-0.2	1.3	0.4
Eye problems/disorders: None of the above	0.3	0.4	0.7	-0.9	-0.5	-0.3
Supplements: Vitamin C	0.3	0.3	0.6	-0.5	-0.3	-0.8
Back pain experienced in last month	0.3	0.4	0.8	-0.4	0.4	0.9
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	-0.3	-0.9	-0.5
Ever taken oral contraceptive pill	0.3	0.4	0.7	0.9	-0.5	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.3	-0.8	0.4
High cholesterol (Self-reported)	0.3	0.6	1.2	-0.4	1.1	0.6
Alcohol drinker status: Never	0.3	0.4	0.5	-0.7	0.7	0.5
Age started oral contraceptive pill	0.3	0.3	0.8	0.3	-0.9	0.2
Diastolic blood pressure, automated reading	0.3	1.0	2.8	0.3	-0.3	1.7
Ever depressed for a whole week	0.3	0.4	0.6	0.8	-0.5	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	-0.2	-0.7	-0.7
Neuroticism (Nagel 2018)	0.2	0.4	1.1	0.3	0.1	1.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	0.6	0.5	0.2
Major Depression (MDD)	0.2	0.3	0.7	0.1	-0.3	0.8
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.3	0.8	0.3
HDL Cholesterol	0.2	0.3	0.4	-0.6	-0.7	-0.3
Lupus	0.2	0.3	0.6	-0.4	0.4	0.8
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.7	0.4	0.4
Lung FEV1/FVC ratio	0.2	0.8	1.3	0.4	1.1	0.9
Tanning	0.2	2.2	3.6	-1.1	-1.3	-1.9
Pack years adult smoking proportion	0.2	0.3	0.5	0.3	0.7	0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.3	0.5	-0.3	0.5
Alcohol usually taken with meals	0.2	0.4	0.6	0.8	0.3	0.7
Heart attack	0.2	0.2	0.5	0.3	0.3	-0.7
Allergy	0.2	0.5	0.9	-0.8	-0.9	-0.2
Neuroticism score	0.2	0.3	0.8	0.4	-0.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.2	0.6	-0.8	0.1	0.4
Noisy workplace	0.2	0.3	0.8	-0.2	0.1	-0.9
Depression (self-reported)	0.2	0.2	0.3	0.5	0.5	0.3
Pulse wave reflection index	0.2	0.2	0.4	-0.4	0.4	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.8	-0.1	0.2
Medication: Paracetamol	0.2	0.3	0.7	0.9	0.2	-0.4
Headache pain in last month	0.2	0.3	0.4	0.4	-0.6	0.5
Comparative body size at age 10	0.2	0.5	1.3	1.1	-0.2	0.3
Mean time to correctly identify matches	0.2	0.3	0.6	-0.8	0.5	-0.4
Heart disease (mother)	0.2	0.3	0.4	0.5	-0.6	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	0.5	-0.4	0.7
Mood swings	0.2	0.3	0.8	-0.9	-0.4	-0.1
Commuting to job workplace: Walk	0.2	0.2	0.7	0.0	0.0	-0.8
Medication: Lisinopril	0.2	0.2	0.4	-0.4	-0.5	0.6
Irritability	0.2	0.3	0.5	0.3	-0.5	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.8	-0.3	-0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	0.2	0.0	-0.9
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	0.3	-0.6	-0.4
Worry (Nagel 2018)	0.1	0.1	0.4	-0.1	-0.7	0.1
Crohns Disease (2017)	0.1	0.3	0.5	-0.4	0.6	0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.4	0.1	-0.2	0.6
Average weekly spirits intake	0.1	0.1	0.2	0.1	-0.3	0.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.0	-0.1	0.5
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.4	0.1	0.6
Angina	0.1	0.1	0.2	-0.1	-0.0	0.5
Vitamin and mineral supplements	0.1	0.2	0.3	-0.5	0.0	0.4
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.5	0.1	0.2
Maternal smoking around birth	0.1	0.2	0.4	0.2	0.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	0.3	0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.0	0.4	-0.3
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.4	0.6	-0.4
Pulse rate	0.1	0.1	0.3	0.1	-0.1	0.5
Asthma	0.1	0.2	0.5	0.7	-0.3	0.0
Pulse wave Arterial Stiffness index	0.1	0.2	0.2	0.2	0.5	0.5
Blood clot in the leg (DVT)	0.1	0.2	0.4	0.0	-0.4	-0.6
Worry too long after embarrassment	0.1	0.1	0.2	0.4	-0.4	-0.0
Wheeze or whistling in the chest in last year	0.1	0.3	0.3	0.5	0.6	0.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.3	-0.2	0.6
Angina (self-reported)	0.1	0.1	0.1	-0.2	-0.2	0.4
Average weekly red wine intake	0.1	0.1	0.2	-0.3	0.1	0.4
Asthma (self-reported)	0.1	0.2	0.6	0.8	-0.1	0.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.1	-0.3	0.3	-0.3
Miserableness	0.1	0.2	0.3	-0.5	0.3	-0.6
Mother’s age at death	0.1	0.1	0.3	0.0	-0.5	0.3
Medication: Paracetamol	0.1	0.1	0.3	0.6	-0.1	-0.3
Medication: Atorvastatin	0.1	0.1	0.1	-0.1	0.4	-0.2
Pack years of smoking	0.1	0.1	0.3	0.0	0.6	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Lung FVC	0.0	0.2	0.3	-0.4	-0.2	-0.5
Hair Pigment	0.0	0.1	0.1	0.3	-0.3	-0.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.3	-0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.1	-0.2	0.3

Hub : Genes

HOOK2

Models

Trait associations