Hub : Genes

ANAPC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0741	0.0387	0.0091	0.034	NA	-0.001	NA	0.015	0.00110	NA	0.410	NA	0.0230
2	GTEx	Esophagus Mucosa	0.0620	0.0280	0.0016	0.023	NA	-0.001	NA	0.003	0.01100	NA	0.400	NA	0.2000
3	ROSMAP	Brain Pre-frontal Cortex	0.0536	0.0291	0.0190	0.018	0.007	0.006	0.01	0.012	0.00200	0.032	0.044	0.017	0.0098
4	TCGA	Soft Tissue Sarcoma	0.0610	0.0340	0.0090	0.047	0.017	0.016	NA	0.024	0.00092	0.033	0.039	NA	0.0140

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	1.3	-0.4	0.6	-0.4	1.1
Bipolar Disorder or Schizophrenia	1.1	2.6	5.1	-1.2	2.2	1.7	-1.1
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	0.2	0.1	1.0	-0.6
Depression (Nagel 2018)	0.5	0.8	2.9	0.4	-0.0	0.4	-1.7
Intelligence (Savage-Jansen 2018)	0.5	1.4	4.3	-0.2	-0.6	-2.1	0.9
Neuroticism (Nagel 2018)	0.4	0.9	2.1	0.1	1.2	1.5	-0.4
Schizophrenia (2018)	2.3	4.8	6.7	-1.2	2.4	2.6	-2.3
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	0.1	0.4	0.7	0.0
Worry (Nagel 2018)	0.2	0.5	1.1	-0.8	1.1	0.4	0.2
Alzheimer’s Disease (in mother)	0.3	0.4	1.4	-0.2	-0.3	-1.2	0.3
Alzheimer’s Disease (in father)	0.5	0.5	1.2	-1.1	0.1	0.4	0.9
Alzheimer’s Disease (including proxy)	0.2	0.4	0.7	0.3	-0.6	-0.9	-0.4
Crohns Disease (2017)	0.4	0.9	2.8	-1.7	-0.3	0.4	0.8
Irritable Bowel Disease (IBD)	0.3	0.6	1.3	-1.2	0.4	0.9	0.2
Ulcerative Colitis (UC)	0.4	0.7	1.5	-0.3	0.9	1.2	-0.6
Major Depression (MDD)	0.0	0.1	0.1	0.3	0.3	0.1	0.0
Reaction Time	1.9	3.5	8.6	-1.2	-2.0	-0.1	2.9
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	-0.8	-0.8	-0.3	-0.4
Breast Cancer	0.6	1.5	2.7	1.6	0.4	-0.7	1.6
Ovarian Cancer	1.0	1.3	2.0	0.6	1.2	-1.4	1.2
Prostate Cancer	1.8	2.6	4.7	1.6	2.2	-0.5	1.6
Age at First Birth	0.4	0.6	2.3	-0.5	-1.5	0.2	0.0
Bipolar Disorder (2011)	0.3	0.2	1.0	-1.0	-0.2	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.6	0.3	-0.4	0.0
Coronary Artery Disease (CAD)	0.3	0.4	1.3	-0.0	-0.6	1.1	0.0
Crohns Disease (2012)	0.9	1.5	3.2	-1.0	0.5	-1.2	1.8
Mean Putamen Volume	0.8	0.9	2.1	-1.0	1.5	-0.4	0.4
Fasting Glucose	0.2	0.2	0.5	-0.7	-0.3	0.6	-0.2
HbA1C	0.1	0.2	0.4	0.1	0.5	-0.6	0.0
HDL Cholesterol	0.5	0.8	1.8	-1.1	0.3	1.3	0.0
LDL Cholesterol	1.3	2.0	5.1	-2.2	-1.4	1.1	0.0
Lupus	0.1	0.2	0.4	-0.5	0.3	0.1	0.7
Neuroticism (2016)	0.4	0.6	1.8	1.3	0.2	0.8	0.0
Primary Biliary Cirrhosis	4.2	5.9	15.4	-3.9	0.9	2.7	-0.4
Rheumatoid Arthritis	0.7	0.9	3.2	0.5	1.8	-0.1	-0.4
Schizophrenia (2014)	2.0	4.4	8.9	-0.8	3.0	1.9	-2.2
Triglycerides	0.4	0.6	2.5	-0.2	1.6	-0.2	0.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	-0.8	1.3	-0.9	0.0
Ulcerative Colitis	0.5	0.7	1.0	-0.7	1.0	0.9	-0.8
Blood Eosinophil Count	1.5	11.5	29.1	3.8	-0.3	-5.4	-1.6
Blood Platelet Count	0.6	7.1	24.1	1.8	0.4	-4.9	1.0
Blood Red Count	3.6	34.8	90.4	-6.5	0.0	9.5	-2.6
Blood White Count	1.9	13.8	23.8	-4.9	-2.8	-4.4	2.0
Heel T-Score	0.6	4.6	8.3	2.3	-0.1	-2.9	-2.2
BMI	0.5	3.0	4.8	-1.2	1.0	2.2	-2.2
Height	0.2	3.6	6.2	2.1	-0.8	-2.5	1.8
Waist Hip Ratio (WHR)	0.3	1.4	1.6	1.0	1.3	-1.2	1.2
Systolic Blood Pressure	0.5	2.4	6.9	-2.6	1.6	-0.6	-0.1
Smoking Status	0.9	2.1	5.2	-1.3	2.3	1.1	-0.5
Allergy or Eczema	0.8	2.0	5.8	1.2	0.3	-0.9	-2.4
Cardiovascular Disease	0.9	3.1	4.8	-2.2	1.8	1.0	-1.8
Hypothyroidism (self reported)	1.0	2.3	3.8	-1.9	0.0	1.6	-1.7
Respiratory disease	0.4	1.0	3.2	0.8	0.1	0.2	-1.8
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.1	-1.0	0.6	-1.1	-0.1
Lung FEV1/FVC ratio	1.4	7.2	15.2	1.3	-2.7	-3.9	2.1
Lung FVC	0.2	1.2	3.2	1.8	-0.6	-1.1	-0.3
Neuroticism	0.3	0.6	1.0	0.0	1.0	1.0	0.8
Chronotype (morning person)	1.5	3.4	10.6	-3.2	-1.1	1.2	0.5
Hair Pigment	0.1	1.6	4.8	-0.5	1.1	2.2	0.0
Tanning	0.1	1.2	4.0	-0.3	-0.8	-2.0	0.2
Hand grip strength (left)	0.4	0.9	1.7	0.4	1.3	-0.9	-1.1
Number of treatments/medications taken	0.4	0.8	1.6	-0.5	1.3	-1.1	-0.3
Average weekly spirits intake	2.5	3.2	8.8	-0.8	-0.7	1.7	-3.0
Sensitivity / hurt feelings	1.1	1.8	6.9	0.3	-0.0	2.6	0.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.6	0.3	0.1	0.5	-1.3
Hearing difficulty/problems: Yes	1.9	2.9	5.0	-0.8	2.0	2.2	-1.4
Relative age of first facial hair	0.3	0.7	1.2	-1.0	-1.1	0.3	0.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.9	-0.4	2.0	-0.5	0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	-0.6	0.1	0.5	0.6
Ever had hysterectomy (womb removed)	1.1	1.2	2.8	-0.1	1.7	1.4	0.4
Systolic blood pressure, automated reading	0.7	2.0	5.1	-2.3	1.5	-0.6	-0.5
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.1	0.6	0.3	-1.0	-2.0
Angina	2.1	2.8	7.1	0.4	-2.7	-1.7	0.8
Medication for hormone replacement therapy	1.3	1.5	3.3	-1.2	0.7	1.8	0.6
Vitamin and mineral supplements	0.9	1.2	2.6	-0.7	0.7	1.6	-1.1
Supplements: Zinc	1.3	1.4	4.4	0.5	2.1	0.9	-0.2
Medication: Co-codamol	1.3	1.5	3.1	0.7	1.4	-1.8	-0.5
Medication: Metformin	0.5	0.7	1.6	0.6	0.8	-1.3	-0.4
Diabetes (father)	1.1	1.3	2.8	-0.8	0.9	-1.7	1.0
Diabetes (mother)	0.9	1.2	1.9	1.4	1.1	-1.2	-0.5
Severe depression (siblings)	0.5	0.5	1.4	0.4	-0.1	0.7	-1.2
Pack years adult smoking proportion	0.8	1.2	4.0	-0.1	-0.3	0.7	-2.0
Impedance of leg (right)	0.7	3.5	9.5	-1.4	3.1	-1.5	-0.2
Leg fat-free mass (left)	0.2	0.9	2.2	0.3	-1.5	1.0	-0.5
Trunk fat percentage	0.7	2.7	8.1	-2.9	0.8	1.4	0.1
Hand grip strength (right)	0.7	1.9	3.4	1.8	0.9	-1.7	-0.7
Townsend deprivation index at recruitment	2.5	3.6	9.8	1.9	3.1	0.3	-0.9
Current tobacco smoking	0.9	1.5	4.6	-1.0	0.7	2.1	0.4
Average weekly fortified wine intake	0.9	1.0	2.1	-1.4	-0.3	-1.0	0.9
Maternal smoking around birth	1.6	2.3	5.3	-1.5	1.1	0.7	-2.3
Fed-up feelings	0.3	0.6	1.7	-0.6	-0.1	1.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	0.8	0.4	0.4	-0.7
Relative age voice broke	1.2	1.8	4.3	-2.1	-1.6	0.3	0.5
Taking other prescription medications	1.2	1.8	5.0	-0.2	2.2	-1.4	-0.6
Age when periods started (menarche)	0.7	1.6	6.2	-0.1	-0.4	-2.5	0.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.5	-0.5	1.2	0.7	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	5.2	-0.9	0.0	-2.3	-0.2
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.1	-0.5	1.4	-1.1	1.5
Qualifications: CSEs or equivalent	0.4	0.6	2.2	0.1	-1.5	0.4	0.2
Serious illness, injury or assault to yourself	0.4	0.4	0.7	-0.8	-0.3	-0.8	0.7
High blood pressure	0.5	1.3	3.5	-1.1	1.9	-0.0	-0.7
Hayfever, allergic rhinitis or eczema	0.9	2.0	5.1	1.1	-0.8	-0.9	-2.3
Multivitamins +/- minerals	1.0	1.2	2.9	0.5	-0.7	-1.7	1.1
Stomach or abdominal pain in last month	1.7	2.1	4.1	0.9	-0.5	-2.0	1.8
Supplements: Glucosamine	1.6	2.2	6.7	0.1	-1.3	-2.6	0.6
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.8	1.2	-1.9	-0.9	-1.1
Medication: Atenolol	0.4	0.5	1.0	0.6	-1.0	-0.9	-0.1
Medication: Levothyroxine sodium	1.2	2.0	7.3	-2.7	0.4	0.2	-0.7
Sitting height	0.4	2.8	9.9	-1.1	0.2	0.1	-3.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	0.8	0.7	1.0	-0.4
High blood pressure (mother)	0.9	1.3	3.8	-0.7	-0.7	0.6	1.9
Body mass index (BMI)	0.6	2.5	6.8	-1.4	-0.4	2.6	-1.1
Impedance of leg (left)	0.7	3.3	8.8	-1.6	3.0	-1.4	0.0
Leg predicted mass (left)	0.2	0.9	2.1	0.3	-1.5	1.1	-0.5
Trunk fat mass	0.5	2.0	5.6	-2.4	0.5	1.5	-0.1
Waist circumference	0.1	0.5	1.4	-0.1	-0.7	1.2	-0.2
Number of incorrect matches in round	0.3	0.5	1.1	0.8	-1.1	0.3	0.3
Past tobacco smoking	0.9	1.6	5.0	0.3	-2.2	-0.0	1.1
Alcohol usually taken with meals	0.6	0.9	1.7	-0.4	-1.3	-1.3	0.4
Nervous feelings	0.4	0.7	1.7	-1.3	0.5	0.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	1.0	1.2	0.1	-0.1
Hearing difficulty/problems with background noise	0.3	0.5	1.5	0.6	1.2	-0.3	0.0
Hair/balding pattern: Pattern 2	1.6	2.0	3.8	-0.3	-1.5	2.0	-1.4
Had menopause	0.6	0.7	1.9	-0.7	0.6	-1.4	0.1
Had other major operations	0.4	0.5	1.6	0.1	1.3	-0.2	-0.5
Forced vital capacity (FVC)	0.3	1.3	2.4	1.5	0.5	-0.6	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	-0.4	0.0	-1.0	-0.8
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.4	1.3	-1.1	-0.2	1.5
Qualifications: None of the above	0.6	1.4	3.6	-1.3	0.4	1.9	-0.5
Financial difficulties in last 2 years	0.6	0.8	2.7	0.3	0.5	-0.1	1.6
Mouth/teeth dental problems	0.6	0.9	3.1	0.2	-0.7	-0.1	1.8
Heart attack	0.6	0.8	2.3	-0.4	-0.1	-0.9	1.5
Allergy	1.0	2.3	5.1	-1.6	1.2	0.4	2.3
Pain all over the body in last month	1.6	1.7	2.3	1.5	1.5	-1.5	0.5
Diabetes (self-reported)	1.0	1.5	5.8	0.3	0.1	-2.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.2	-0.5	-1.5	-0.4	-0.2
Medication: Ramipril	2.0	2.6	8.5	-0.3	-0.8	-2.9	1.1
Medication: Simvastatin	0.7	1.0	2.8	0.5	-0.1	-0.9	1.7
Fluid intelligence score	0.4	0.8	3.1	0.0	0.0	-1.8	0.5
Illnesses of siblings	0.4	0.6	2.3	-0.0	0.3	1.5	0.2
Neuroticism score	0.4	0.8	2.2	-0.9	0.4	1.5	0.4
Weight	0.3	1.4	2.9	-1.1	-0.2	1.7	-1.2
Impedance of arm (right)	0.6	2.9	3.8	-2.0	1.6	-1.4	1.8
Arm fat percentage (right)	0.6	2.5	5.3	-2.3	0.4	2.1	0.1
Trunk fat-free mass	0.2	1.2	1.9	1.1	-1.4	0.2	-1.1
Hip circumference	0.3	1.2	1.8	-1.2	-0.7	1.4	-1.1
Time employed in main current job	0.4	0.4	1.3	-0.0	-0.0	-0.7	1.1
Alcohol intake versus 10 years previously	0.8	1.1	2.5	1.6	-1.1	-0.5	0.7
Father’s age at death	0.9	1.2	3.0	1.7	-1.2	0.3	0.6
Worrier / anxious feelings	0.6	1.1	2.4	-1.4	-0.2	1.5	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.8	0.3	-0.3	1.4	-0.8
Falls in the last year	0.7	0.9	1.8	1.3	1.1	-0.8	-0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.1	-0.3	0.7	-0.4
Number of live births	1.5	2.1	4.8	-2.2	1.3	0.3	-1.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.8	1.7	-0.2	-1.5	-0.6
Pulse rate	0.9	1.6	4.3	2.1	0.8	-0.6	1.0
Happiness	0.1	0.1	0.2	-0.3	-0.3	-0.5	0.4
Noisy workplace	0.4	0.5	0.7	-0.8	0.8	0.7	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.2	0.7	0.6	-1.5	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	-0.8	0.1	-0.6	1.3
Mouth/teeth dental problems: Dentures	0.2	0.3	1.1	-0.2	1.0	-0.4	-0.3
Asthma	1.0	2.0	6.3	2.5	0.6	0.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	0.2	-0.6	1.0	-0.1
Medication: Cholesterol lowering	0.8	1.2	3.5	1.1	-0.4	-1.9	0.3
Depression (self-reported)	0.8	0.9	2.2	0.8	-0.5	-1.5	-0.8
Medication: Lansoprazole	0.7	0.8	1.8	-0.4	1.1	-1.3	0.3
Prospective memory result	0.8	1.0	2.7	1.1	0.4	-0.3	-1.7
Lung cancer (father)	0.8	0.9	2.7	-0.9	0.4	1.6	-0.1
Illnesses of mother	1.1	1.4	2.7	-0.6	-0.2	1.7	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.9	1.6	0.0	-2.0	-0.8
Pulse wave Arterial Stiffness index	2.8	3.2	6.8	0.0	2.2	1.2	-2.6
Impedance of arm (left)	0.7	3.3	5.1	-2.1	1.5	-1.2	2.2
Arm fat mass (right)	0.5	2.0	5.0	-1.5	-0.0	2.2	-0.8
Trunk predicted mass	0.2	1.1	1.8	1.2	-1.4	0.2	-1.1
Standing height	0.1	0.9	3.0	0.6	0.6	-1.7	-0.3
Length of working week for main job	1.3	1.4	4.3	0.2	-2.1	1.1	0.5
Exposure to tobacco smoke at home	0.4	0.5	1.3	-1.1	-0.5	0.5	-0.5
Breastfed as a baby	2.0	2.5	9.0	-0.7	0.7	3.0	-0.3
Tense / ‘highly strung’	0.7	1.2	4.1	0.2	2.0	-0.9	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	1.5	0.3	1.2	-0.7	-0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	-0.8	0.3	-0.5	0.5
Birth weight of first child	0.9	1.6	2.1	1.4	-1.0	1.5	-1.2
Peak expiratory flow (PEF)	0.4	0.9	3.3	0.6	-0.2	-1.8	-0.2
Pulse wave reflection index	3.7	4.5	14.1	-0.7	1.2	1.4	-3.8
Ever highly irritable/argumentative for 2 days	3.7	4.4	7.8	0.1	2.8	1.9	-2.5
Loud music exposure frequency	1.6	1.8	6.6	-0.2	-0.3	0.6	-2.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.3	-0.0	-1.3	-1.5	1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.8	-0.3	-0.7	-0.7	-1.4
Blood clot in the leg (DVT)	0.7	0.9	3.2	-0.3	-1.8	0.3	0.4
Medication: Paracetamol	1.0	1.7	2.2	-1.5	-1.4	1.0	-1.2
Headache pain in last month	0.3	0.5	1.6	0.6	0.1	1.3	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.5	-0.3	0.2	1.2	0.1
Glaucoma (self-reported)	1.0	1.1	3.0	-0.2	-0.5	1.7	-1.1
Gout (self-reported)	0.5	0.7	2.4	-0.4	0.3	-1.6	0.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	5.7	-2.4	-0.0	0.1	-0.7
Medication: Amlodipine	1.0	1.4	3.5	1.5	-0.3	-1.9	-0.2
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.3	0.8	0.2	-0.5	-2.1
Birth weight	0.3	0.8	2.0	1.4	0.4	0.9	-0.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.8	-0.8	1.7	-1.5	0.1
High blood pressure (siblings)	0.4	0.6	1.6	1.2	-0.1	-0.9	-0.2
Forced vital capacity (FVC), Best measure	0.6	2.1	3.6	1.9	0.9	-1.2	-1.7
Body fat percentage	0.8	3.2	8.8	-3.0	1.0	1.7	0.1
Leg fat percentage (right)	0.7	2.4	3.8	-2.0	1.5	1.7	-0.8
Arm fat-free mass (right)	0.1	0.7	1.5	0.2	-0.8	0.8	-1.2
Exposure to tobacco smoke outside home	0.2	0.3	0.6	-0.7	0.8	0.4	0.1
Comparative body size at age 10	0.5	1.4	4.4	0.5	1.0	2.1	0.2
Number of full brothers	1.1	1.4	3.1	1.8	-0.4	0.4	-1.4
Worry too long after embarrassment	0.9	1.5	2.7	-0.4	1.2	1.6	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	0.2	1.3	-0.9	-0.4
Wheeze or whistling in the chest in last year	1.2	2.1	3.6	1.0	1.9	-0.7	-1.8
Number of children fathered	2.4	2.7	5.9	-2.1	-0.0	2.4	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.1	0.3	1.1	1.0	-0.1
Age at first live birth	1.3	2.4	5.3	0.2	-2.3	1.6	-1.2
Pulse wave peak to peak time	3.0	3.5	8.1	-0.0	-2.1	-1.3	2.8
Health satisfaction	0.2	0.2	0.7	-0.8	0.2	0.2	-0.5
Shortness of breath walking on level ground	0.5	0.6	1.1	-0.4	-1.0	-1.0	-0.4
Qualifications: College or University degree	0.4	1.3	2.3	1.5	-0.4	-1.4	0.9
Eye problems/disorders: None of the above	1.3	1.5	5.7	-0.1	0.4	0.4	2.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	0.0	0.6	1.3	-0.7
Emphysema/chronic bronchitis	0.4	0.4	0.6	0.5	-0.4	-0.8	0.8
Medication for pain relief, constipation, heartburn	0.4	0.6	2.0	-0.0	0.1	-0.7	1.4
Neck or shoulder pain in last month	0.8	1.1	2.5	1.6	1.1	-0.3	-0.8
Medication: Blood pressure	0.2	0.3	0.9	0.3	0.1	-0.9	0.3
Angina (self-reported)	2.4	3.1	7.0	0.6	-2.6	-2.1	1.0
Migraine (self-reported)	1.0	1.3	2.5	1.6	1.6	-0.2	-0.4
Medication: Ibuprofen	0.4	0.4	1.2	0.1	-1.1	0.6	0.4
Medication: Allopurinol	0.4	0.5	1.4	-0.4	0.6	-1.2	0.2
Medication: Omeprazole	1.0	1.2	2.8	1.3	-0.5	-1.7	0.4
Medication: Seretide 50 evohaler	1.3	1.5	1.8	1.3	1.1	-1.2	1.2
Mean time to correctly identify matches	1.3	2.5	4.7	-0.9	-2.0	-0.5	2.2
Heart disease (mother)	0.2	0.2	0.7	0.8	-0.1	-0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	0.4	0.6	0.2	0.8
Whole body fat mass	0.5	2.0	4.8	-2.2	0.5	1.7	-0.5
Leg fat mass (right)	0.5	1.9	3.4	-1.4	1.1	1.8	-0.8
Arm predicted mass (right)	0.1	0.7	1.8	0.4	-0.7	0.4	-1.4
Pulse rate, automated reading	0.1	0.4	0.6	0.8	-0.2	-0.4	-0.8
Alcohol intake frequency.	0.2	0.5	1.7	1.3	-0.3	-0.5	0.1
Comparative height size at age 10	0.5	2.7	5.4	1.4	1.8	-2.3	0.2
Number of full sisters	0.5	0.6	1.4	1.2	-0.7	0.6	-0.1
Suffer from ‘nerves’	0.2	0.3	0.6	-0.8	0.7	-0.4	0.2
Overall health rating	0.3	0.6	1.6	-1.3	0.6	-0.5	-0.1
Chest pain or discomfort	0.6	0.9	2.6	1.6	0.1	-0.8	0.5
Had major operations	0.9	1.0	2.0	-0.7	1.2	-0.4	-1.4
Age at last live birth	1.7	2.5	4.9	1.8	-2.2	0.7	-1.1
Family relationship satisfaction	0.7	0.9	2.5	1.6	0.0	-1.1	0.0
Leg pain on walking	0.9	1.2	3.1	1.8	0.8	-0.4	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.9	1.0	1.0	0.7	-2.0
Commuting to job workplace: Car/motor vehicle	2.0	2.3	6.3	-1.2	-1.2	2.5	0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.1	-0.1	-0.7	-0.2	-1.4
Medication: Aspirin	0.9	1.2	3.6	0.2	0.3	-1.9	1.0
Supplements: Vitamin C	0.5	0.6	1.0	0.5	-1.0	-0.8	-0.6
Knee pain experienced in last month	0.8	1.2	2.0	-1.2	-0.2	1.4	-1.2
Hypertension (Self-reported)	0.3	0.8	1.7	-1.1	1.3	0.1	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.6	1.1	0.9	-1.6	-0.4
Illnesses of father: Heart disease	0.6	0.9	2.1	-0.6	1.0	0.4	-1.4
Illnesses of siblings: Diabetes	1.1	1.4	5.3	0.2	0.3	-2.3	-0.3
Smoking status: Previous	1.1	1.6	4.7	-0.3	2.2	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.6	-1.2	0.4	0.1	-1.2
Whole body fat-free mass	0.2	1.0	2.2	0.8	-1.5	0.5	-1.0
Leg fat-free mass (right)	0.2	1.0	2.6	0.7	-1.6	0.9	-0.4
Arm fat percentage (left)	0.7	2.7	5.9	-2.4	0.6	2.1	0.2
Average weekly red wine intake	0.2	0.3	0.8	0.2	-0.5	0.3	-0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	-0.1	-0.3	0.2	-0.6
Mood swings	0.7	1.3	4.7	-0.4	-0.5	2.2	-0.4
Loneliness, isolation	0.6	0.8	2.0	-0.5	0.8	1.4	0.6
Long-standing illness, disability or infirmity	1.0	1.6	3.5	0.5	1.9	-1.5	-0.5
Ever had bowel cancer screening	0.8	0.9	1.6	-0.1	-1.2	-1.3	0.8
Diabetes diagnosed by doctor	0.9	1.4	5.6	-0.0	-0.4	-2.4	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.4	1.2	-1.5	-0.4	0.4
Friendships satisfaction	0.2	0.3	0.7	0.4	0.3	-0.2	-0.9
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.1	-0.3	-0.6	-0.9
Commuting to job workplace: Walk	0.9	1.0	3.1	0.2	0.3	-1.8	-0.8
Eye problems/disorders: Cataract	0.7	0.8	2.2	0.5	-0.6	-1.5	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	6.1	0.4	1.2	0.4	-2.5
Medication for cholesterol	1.1	1.6	4.5	2.1	-0.8	-1.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.9	1.1	-0.1	0.7	-1.4
Back pain experienced in last month	0.1	0.2	0.7	0.1	-0.8	0.2	0.1
Mineral and other dietary supplements	1.4	1.9	3.8	-0.4	-0.6	1.9	-1.9
Breast cancer (self-reported)	0.7	0.9	1.8	1.3	0.1	-1.3	0.2
Asthma (self-reported)	1.0	2.0	5.7	2.4	0.8	0.1	-1.4
Osteoporosis (self-reported)	2.0	2.5	7.8	-0.7	1.1	-0.7	2.8
Osteoarthritis (self-reported)	0.3	0.4	0.9	0.4	0.3	-1.0	0.6
Medication: Aspirin	0.7	0.9	3.2	-0.0	0.2	-1.8	0.5
Medication: Gliclazide	3.5	3.9	5.8	1.6	2.4	-1.4	2.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.2	0.9	-1.1	-0.7	0.4
Smoking status: Current	1.0	1.7	4.9	-1.2	0.0	2.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	8.7	0.8	-1.4	-3.0	0.3
Whole body water mass	0.2	1.1	2.4	0.9	-1.6	0.5	-1.0
Leg predicted mass (right)	0.2	1.0	2.9	0.7	-1.7	0.8	-0.3
Arm fat mass (left)	0.5	1.9	4.5	-1.6	0.2	2.1	-0.7
Number of self-reported non-cancer illnesses	0.6	1.0	3.3	0.2	0.8	-1.8	-0.1
Average weekly champagne plus white wine intake	0.9	1.2	3.6	-0.8	0.4	1.9	-0.8
Miserableness	0.2	0.4	1.4	0.2	-1.2	0.2	0.2
Guilty feelings	0.2	0.2	0.6	-0.2	0.7	0.3	0.5
Wears glasses or contact lenses	0.5	0.6	1.3	-0.7	0.8	-0.3	-1.2
Ever taken oral contraceptive pill	0.6	0.6	1.0	0.9	-0.9	0.1	1.0
Hearing aid user	1.7	1.9	5.0	-1.6	-0.1	2.2	0.3
Mother’s age at death	0.4	0.5	0.7	-0.9	-0.2	-0.8	0.9
Financial situation satisfaction	0.3	0.4	1.2	-0.7	-0.1	-0.0	1.1
Tinnitus: Yes, now most or all of the time	1.4	1.6	2.7	1.4	-1.6	1.1	-0.7
Commuting to job workplace: Public transport	0.7	0.9	3.3	0.2	-0.2	-1.8	0.2
Eye problems/disorders: Glaucoma	1.6	1.9	4.6	0.1	-0.6	2.1	-1.6
Medication: Blood pressure	0.4	0.7	1.4	-1.2	0.9	-0.5	-0.6
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.3	0.0	0.1	0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.1	0.7	-0.5	-1.8	1.7
High cholesterol (Self-reported)	0.4	0.7	1.1	-1.1	0.9	-0.7	-0.8
Medication: Bendroflumethiazide	1.0	1.6	4.3	-0.1	2.1	-0.2	-1.4
Medication: Paracetamol	0.7	1.1	2.6	-1.2	-1.6	0.4	-0.3
Medication: Lisinopril	1.1	1.4	4.1	-0.5	2.0	-0.6	-1.0
Medication: Atorvastatin	1.8	2.2	4.9	-2.2	0.1	-1.2	-1.6
Illnesses of father: High blood pressure	0.6	0.8	2.4	-0.6	1.6	-0.3	-0.5
Alcohol drinker status: Never	1.4	1.7	5.3	1.0	-2.3	-0.0	-0.8
Ever smoked	1.2	2.1	6.8	0.3	2.6	0.8	-1.1
Basal metabolic rate	0.2	1.0	1.8	0.4	-1.4	0.9	-1.2
Leg fat percentage (left)	0.7	2.5	4.3	-2.1	1.3	1.9	-0.6
Arm fat-free mass (left)	0.3	1.5	3.4	1.1	-1.0	0.7	-1.8
Number of operations (self-reported)	1.1	1.7	6.1	0.1	2.5	-0.1	-0.8
Average weekly beer plus cider intake	0.7	1.0	2.1	-0.9	1.0	1.5	-0.6
Irritability	0.4	0.7	2.0	0.2	0.8	1.4	0.5
Risk taking	0.2	0.2	0.5	0.1	0.7	0.3	-0.6
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.3	0.1	-1.1	0.9	-1.5
Fractured/broken bones in last 5 years	0.9	1.2	2.2	1.5	0.9	0.6	1.2
Age started oral contraceptive pill	1.8	2.3	2.8	1.7	1.1	-1.7	1.4
Diastolic blood pressure, automated reading	0.7	2.2	3.1	-1.8	1.7	0.9	-1.4
Ever depressed for a whole week	0.3	0.3	0.6	0.6	-0.1	0.8	0.6
Unable to work because of sickness or disability	1.8	2.3	5.0	1.0	2.2	1.8	-0.3
Commuting to job workplace: Cycle	1.4	1.6	2.8	0.8	-1.5	-1.7	-1.0
Myopia	0.5	0.7	1.7	-0.6	-0.5	-0.6	1.3
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.2	0.7	-1.1	-0.0	0.0
Cholesterol lowering medication	0.8	1.2	2.7	-1.6	0.8	0.1	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.6	0.9	0.4	-1.6	-0.2
Pain experienced in last month	0.5	0.8	1.7	-0.7	-0.1	-1.3	1.0
Supplements: Calcium	1.4	1.5	5.4	-0.7	2.3	0.3	-0.0
Basal cell carcinoma (self-reported)	1.1	1.3	3.4	0.7	1.0	1.8	-0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.2	-0.4	-0.6	-0.9	1.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.4	-0.2	-1.8	0.1	0.4
Heart disease (siblings)	1.3	1.6	4.1	-1.0	-0.5	-2.0	1.1
Alcohol drinker status: Previous	2.2	2.5	4.9	0.6	1.4	-1.8	2.2
Pack years of smoking	0.9	1.3	4.8	0.1	-0.3	0.5	-2.2
Impedance of whole body	0.7	3.6	5.7	-2.2	2.4	-1.5	1.3
Leg fat mass (left)	0.5	1.8	3.6	-1.5	0.9	1.9	-0.8
Arm predicted mass (left)	0.4	1.8	4.2	0.9	-1.2	0.9	-2.0