TWAS hub - LOC541471

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0322	0.0189	2.1e-03	0.000	0.008	0.010	NA	0.001	0.37000	8.2e-03	2.6e-03	NA	1.6e-01
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.1202	0.0449	4.7e-07	0.029	0.065	0.049	NA	0.051	0.00027	8.3e-08	2.8e-06	NA	1.8e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Birth weight	6.5	14.1	17.1	4.1	3.3
Had major operations	6.0	7.0	11.3	3.4	1.7
Medication: Metformin	5.3	7.5	10.4	-2.1	-3.2
Blood Eosinophil Count	5.2	40.3	53.4	5.2	7.3
Diabetes (self-reported)	4.7	7.2	8.6	-2.4	-2.9
Hearing aid user	4.6	5.2	6.5	2.0	2.5
Blood Red Count	4.3	41.1	74.3	-8.6	-2.8
Type 2 Diabetes (T2D) (2018)	4.2	7.9	8.9	-3.0	-2.6
Lung cancer (father)	4.2	4.9	5.7	-2.4	-2.0
Medication: Ibuprofen	4.2	5.1	7.5	2.7	1.6
Medication: Ibuprofen (e.g. Nurofen)	4.1	5.2	6.8	2.6	1.9
Migraine (self-reported)	4.0	5.0	6.5	2.5	1.9
Leg fat-free mass (right)	4.0	21.3	23.3	4.8	4.4
Leg predicted mass (right)	3.9	20.6	22.3	4.7	4.3
Impedance of leg (right)	3.8	18.6	19.5	-4.2	-4.4
Leg fat-free mass (left)	3.5	18.6	19.4	4.4	4.2
Impedance of leg (left)	3.5	17.2	19.3	-3.9	-4.4
Leg predicted mass (left)	3.5	18.5	19.2	4.4	4.2
Diabetes diagnosed by doctor	3.3	5.4	5.5	-2.3	-2.3
Hip circumference	3.1	13.3	24.0	1.6	4.9
Diabetes (father)	3.0	3.7	4.0	-1.8	-2.0
Rheumatoid Arthritis	2.9	4.0	8.1	0.0	2.8
Vitamin and mineral supplements	2.9	3.9	4.6	-1.8	-2.1
Whole body fat-free mass	2.8	15.8	17.6	4.2	3.8
Medication: Paracetamol	2.7	4.2	5.1	1.8	2.2
Basal metabolic rate	2.7	15.1	15.8	4.0	3.8
Number of operations (self-reported)	2.7	4.0	5.5	1.6	2.3
Age at last live birth	2.6	3.8	7.5	2.7	0.4
Whole body water mass	2.6	14.7	16.2	4.0	3.6
Weight	2.5	12.3	15.9	2.9	4.0
Birth weight of first child	2.5	4.5	6.0	2.5	1.7
Lung FEV1/FVC ratio	2.3	11.5	19.1	-2.0	-4.4
Trunk predicted mass	2.3	12.9	14.8	3.9	3.3
Breastfed as a baby	2.3	2.9	5.7	-2.4	-0.2
Myopia	2.3	3.4	5.9	-0.9	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.1	6.4	2.5	1.9
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	6.9	2.6	1.6
Trunk fat-free mass	2.1	12.3	14.4	3.8	3.2
Medication: Paracetamol	2.1	3.5	4.6	1.6	2.1
Friendships satisfaction	2.1	2.5	2.5	1.6	1.6
Average weekly fortified wine intake	2.0	2.3	3.5	1.9	1.1
Arm fat-free mass (right)	2.0	10.0	11.2	3.0	3.4
Family relationship satisfaction	2.0	2.4	4.1	0.9	2.0
Sitting height	1.9	13.4	15.0	3.9	3.4
Waist circumference	1.9	7.0	9.4	2.1	3.1
Arm fat mass (right)	1.9	7.7	10.8	2.1	3.3
Chronic bronchitis/emphysema (mother)	1.9	2.3	2.3	-1.5	-1.5
Illnesses of father: Heart disease	1.9	2.6	5.2	0.2	2.3
Illnesses of siblings: Diabetes	1.9	2.3	4.1	-0.8	-2.0
Forced vital capacity (FVC)	1.8	6.9	8.4	2.3	2.9
Noisy workplace	1.8	2.2	3.3	1.1	1.8
Glaucoma (self-reported)	1.8	2.2	4.1	-0.5	-2.0
Eye problems/disorders: Cataract	1.8	2.1	3.4	-0.9	-1.8
Wears glasses or contact lenses	1.8	2.1	2.7	-1.3	-1.6
Primary Biliary Cirrhosis	1.7	2.4	3.9	1.0	-2.0
Heel T-Score	1.7	13.7	23.7	4.9	1.9
Medication: Gliclazide	1.7	2.0	2.8	-1.7	-1.1
Arm fat mass (left)	1.7	7.0	10.2	2.0	3.2
Basal cell carcinoma (self-reported)	1.7	2.1	3.8	1.9	0.6
Schizophrenia (2018)	1.6	3.3	6.6	0.0	2.6
Trunk fat mass	1.6	6.9	10.0	1.9	3.2
Alcohol intake versus 10 years previously	1.6	2.4	2.5	1.5	1.6
Age at first live birth	1.6	2.9	5.6	2.4	-0.3
Arm predicted mass (right)	1.6	8.4	8.9	2.8	3.0
Mineral and other dietary supplements	1.6	2.2	3.3	-1.0	-1.8
Supplements: Fish oil (including cod liver oil)	1.6	2.0	3.2	0.9	1.8
Arm fat-free mass (left)	1.6	8.4	8.7	2.8	2.9
Arm predicted mass (left)	1.6	8.3	8.5	2.9	2.8
Smoking Status	1.5	3.7	6.0	-1.2	-2.5
Hearing difficulty/problems: Yes	1.5	2.3	3.3	1.2	1.8
Length of working week for main job	1.5	1.6	2.6	-0.8	1.6
Wheeze or whistling in the chest in last year	1.5	2.7	2.8	1.6	1.7
Whole body fat mass	1.5	6.3	9.7	1.7	3.1
Comparative height size at age 10	1.5	8.1	8.6	2.7	2.9
HbA1C	1.4	1.5	2.5	1.6	-0.7
Ever used hormone-replacement therapy (HRT)	1.4	1.8	2.3	-1.5	-1.2
Pack years adult smoking proportion	1.4	2.2	2.5	1.6	1.4
Body mass index (BMI)	1.4	5.9	10.0	1.4	3.2
Arm fat percentage (right)	1.4	5.3	8.1	1.6	2.9
Exposure to tobacco smoke at home	1.4	1.5	1.9	-1.4	-1.1
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.4	-1.0	-1.5
Arm fat percentage (left)	1.4	5.7	8.8	1.6	3.0
Medication: Atorvastatin	1.4	1.8	2.8	-1.7	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	2.3	1.1	1.5
Impedance of whole body	1.4	7.3	9.3	-2.3	-3.0
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.2	1.1	1.5
Systolic blood pressure, automated reading	1.3	3.9	6.0	1.3	2.5
Worrier / anxious feelings	1.3	2.5	2.6	-1.6	1.6
Blood clot in the leg (DVT)	1.3	1.7	2.0	1.2	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.3	1.5	0.9
Medication for pain relief, constipation, heartburn	1.3	2.2	3.0	-1.2	-1.7
Illnesses of father: None of the above (group 1)	1.3	1.6	3.0	0.4	-1.7
Diastolic blood pressure, automated reading	1.3	4.1	6.8	1.2	2.6
Pack years of smoking	1.3	2.0	2.2	1.5	1.3
Ovarian Cancer	1.2	1.6	3.2	-1.8	0.3
Multivitamins +/- minerals	1.2	1.5	1.6	1.2	1.3
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	4.2	2.0	1.9
Comparative body size at age 10	1.2	3.3	5.5	1.1	2.4
Overall health rating	1.2	2.7	4.7	0.8	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.5	0.4	1.6
Commuting to job workplace: Cycle	1.2	1.4	1.5	1.2	-1.1
Supplements: Calcium	1.2	1.3	2.0	-1.4	0.8
Reaction Time	1.1	2.0	2.4	-1.6	-1.3
Chronotype (morning person)	1.1	2.5	4.8	-2.2	-0.3
Had menopause	1.1	1.4	2.8	-1.7	-0.1
Headache pain in last month	1.1	1.9	2.8	1.7	1.0
Worry too long after embarrassment	1.1	1.8	3.6	-1.9	0.0
Neck or shoulder pain in last month	1.1	1.6	3.2	-0.0	1.8
Medication: Blood pressure	1.1	2.1	4.1	-0.3	2.0
Unable to work because of sickness or disability	1.1	1.4	2.5	1.6	0.5
Neuroticism	1.0	2.4	3.5	-1.9	-1.2
Standing height	1.0	10.1	15.5	3.9	2.1
High blood pressure (siblings)	1.0	1.4	1.6	-1.3	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	1.4	1.2	0.9
Back pain experienced in last month	1.0	1.4	2.1	-0.9	-1.4
Medication: Bendroflumethiazide	1.0	1.5	2.3	0.9	1.5
Bipolar Disorder or Schizophrenia	0.9	2.2	4.4	0.0	2.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.0	-1.0	-1.0
Trunk fat percentage	0.9	3.6	6.1	1.1	2.5
Maternal smoking around birth	0.9	1.3	2.1	-0.7	1.5
Alcohol usually taken with meals	0.9	1.4	1.7	-1.1	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.6	1.6	0.5
Allergy	0.9	2.1	3.6	-1.9	-0.7
Illnesses of siblings	0.9	1.3	2.6	1.6	-0.2
Hypertension (Self-reported)	0.9	2.5	4.7	-0.4	2.2
Illnesses of father: High blood pressure	0.9	1.1	1.8	0.6	1.3
Worry (Nagel 2018)	0.8	1.7	3.4	-1.8	0.2
Height	0.8	14.6	15.0	3.9	3.8
Waist Hip Ratio (WHR)	0.8	3.5	6.2	0.9	-2.5
Medication for hormone replacement therapy	0.8	0.9	1.2	-1.1	-0.8
Fed-up feelings	0.8	1.4	2.2	-1.5	-0.8
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.3	-1.1	-0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.3	-0.6	-1.1
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.4	1.9	0.4
Number of incorrect matches in round	0.8	1.3	2.2	-0.6	-1.5
Had other major operations	0.8	1.0	1.5	-0.8	1.2
Hair/balding pattern: Pattern 4	0.8	1.9	2.0	1.4	1.3
Peak expiratory flow (PEF)	0.8	1.8	2.0	1.4	1.3
Gout (self-reported)	0.8	1.0	1.8	-1.4	0.5
Body fat percentage	0.8	3.3	6.2	0.7	2.5
Eye problems/disorders: None of the above	0.8	0.9	1.5	0.6	1.2
Angina (self-reported)	0.8	1.1	1.3	-1.0	-1.1
Pulse rate, automated reading	0.8	2.5	3.3	-1.3	-1.8
Medication: Aspirin	0.8	1.1	1.5	-1.2	-0.8
Coronary Artery Disease (CAD)	0.7	0.8	1.6	0.0	1.3
Ulcerative Colitis	0.7	1.0	2.0	0.0	1.4
BMI	0.7	3.9	7.8	0.1	2.8
Angina	0.7	0.9	1.0	-1.0	-0.9
High blood pressure	0.7	2.0	3.9	-0.2	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.4	1.2	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.7	1.5	0.1	1.2
Asthma	0.7	1.4	1.7	1.1	1.3
Pulse wave peak to peak time	0.7	0.8	1.0	1.0	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.6	-0.3	-1.3
Leg pain on walking	0.7	0.9	1.1	0.8	1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.2	-1.1	-0.7
Leg fat mass (left)	0.7	2.8	5.3	0.6	2.3
Depressed Affect (Nagel 2018)	0.6	1.2	1.9	-1.4	-0.7
Neuroticism (Nagel 2018)	0.6	1.5	2.9	-1.7	-0.2
Ulcerative Colitis (UC)	0.6	1.2	2.4	0.1	1.5
HDL Cholesterol	0.6	1.0	2.0	0.0	-1.4
Neuroticism (2016)	0.6	0.8	1.0	-0.9	1.0
Schizophrenia (2014)	0.6	1.3	2.5	0.0	1.6
Allergy or Eczema	0.6	1.7	2.9	1.7	0.6
Supplements: Zinc	0.6	0.6	0.9	-0.5	1.0
Hand grip strength (right)	0.6	1.7	1.8	1.4	1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	0.1	1.2
Medication: Seretide 50 evohaler	0.6	0.7	0.8	0.8	0.9
Leg fat mass (right)	0.6	2.5	4.8	0.4	2.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.0	0.7	1.0
Medication: Aspirin	0.6	0.8	1.2	-1.1	-0.7
Osteoporosis (self-reported)	0.6	0.7	1.2	-1.1	-0.4
Ever smoked	0.6	1.1	2.2	-0.2	-1.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.2	1.1	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	0.8	0.9	0.8
Crohns Disease (2017)	0.5	1.2	1.6	-1.3	-0.9
Breast Cancer	0.5	1.2	1.9	-1.4	-0.7
Respiratory disease	0.5	1.1	1.3	0.9	1.1
Lung FVC	0.5	2.4	2.6	1.5	1.6
Current tobacco smoking	0.5	0.9	0.9	-0.9	-0.9
Relative age voice broke	0.5	0.7	1.4	-0.0	-1.2
Age when periods started (menarche)	0.5	1.1	1.8	1.3	0.6
Qualifications: CSEs or equivalent	0.5	0.6	0.7	0.7	-0.9
Nervous feelings	0.5	0.9	0.9	-0.9	1.0
Qualifications: None of the above	0.5	1.0	1.9	-1.4	0.2
Mouth/teeth dental problems	0.5	0.8	1.6	0.1	-1.2
Time employed in main current job	0.5	0.6	0.6	0.8	0.8
Medication: Cholesterol lowering	0.5	0.7	1.5	0.2	-1.2
Depression (self-reported)	0.5	0.6	1.1	1.0	0.3
Illnesses of mother	0.5	0.6	0.9	0.9	-0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	0.0	1.1
Qualifications: College or University degree	0.5	1.7	2.0	1.1	1.4
Medication: Allopurinol	0.5	0.7	1.0	-1.0	-0.6
Mean time to correctly identify matches	0.5	1.0	1.7	-1.3	-0.5
Heart disease (mother)	0.5	0.7	1.0	0.6	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.0	0.3	-1.0
Mood swings	0.5	0.9	1.5	0.5	1.2
Smoking status: Current	0.5	0.8	1.2	-1.1	-0.7
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.3	0.5	-1.5
Alcohol drinker status: Previous	0.5	0.6	1.0	-1.0	-0.4
Body Mass Index (BMI) (2010)	0.4	0.5	0.8	-0.5	0.9
Mean Putamen Volume	0.4	0.5	0.8	0.4	-0.9
Triglycerides	0.4	0.6	1.2	0.0	-1.1
Cardiovascular Disease	0.4	1.3	1.6	-1.3	1.0
Average weekly spirits intake	0.4	0.5	0.7	0.8	-0.5
Taking other prescription medications	0.4	0.6	0.8	0.9	0.6
High blood pressure (mother)	0.4	0.5	1.1	-0.1	1.0
Neuroticism score	0.4	0.9	1.6	-1.3	0.4
Impedance of arm (right)	0.4	1.6	3.2	-0.3	-1.8
Prospective memory result	0.4	0.5	0.7	0.9	0.4
Pulse wave Arterial Stiffness index	0.4	0.4	0.5	-0.7	-0.6
Forced vital capacity (FVC), Best measure	0.4	1.4	1.8	1.0	1.3
Leg fat percentage (right)	0.4	1.5	1.9	-1.1	1.4
Number of full brothers	0.4	0.5	0.5	0.7	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	0.2	-1.0
Knee pain experienced in last month	0.4	0.7	1.1	0.5	1.1
Ever had bowel cancer screening	0.4	0.5	0.9	-0.4	0.9
Qualifications: nursing, teaching	0.4	0.6	1.2	1.1	-0.0
Breast cancer (self-reported)	0.4	0.5	0.6	0.6	-0.8
Asthma (self-reported)	0.4	0.8	0.8	0.9	0.9
Average weekly champagne plus white wine intake	0.4	0.6	1.0	-1.0	-0.3
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	0.4	-0.9
Alcohol drinker status: Never	0.4	0.5	0.5	-0.7	-0.7
Leg fat percentage (left)	0.4	1.6	2.6	-0.8	1.6
Fractured/broken bones in last 5 years	0.4	0.6	1.1	0.3	1.0
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.6	1.3	-0.2
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.8	0.0
Major Depression (MDD)	0.3	0.4	0.8	0.0	0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	-0.3	-0.8
Blood Platelet Count	0.3	3.8	5.2	2.3	-1.5
Hypothyroidism (self reported)	0.3	0.6	1.2	0.2	-1.1
Number of treatments/medications taken	0.3	0.6	0.9	0.5	0.9
Stomach or abdominal pain in last month	0.3	0.4	0.5	-0.6	0.7
Medication: Levothyroxine sodium	0.3	0.6	0.8	0.9	-0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	0.6	0.6	0.8
Medication: Simvastatin	0.3	0.4	0.7	0.4	-0.8
Pulse rate	0.3	0.5	0.7	-0.5	-0.8
Medication: Lansoprazole	0.3	0.4	0.5	-0.7	-0.6
Impedance of arm (left)	0.3	1.3	2.4	-0.4	-1.6
Pulse wave reflection index	0.3	0.3	0.6	0.3	0.8
Medication: Amlodipine	0.3	0.4	0.5	0.7	0.6
Medication: Blood pressure	0.3	0.5	1.0	-0.3	1.0
Medication: Omeprazole	0.3	0.3	0.6	0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.2	-1.1	-0.3
Guilty feelings	0.3	0.4	0.5	-0.6	0.7
Medication: Lisinopril	0.3	0.4	0.8	0.1	0.9
Pain experienced in last month	0.3	0.4	0.8	0.1	-0.9
Heart disease (siblings)	0.3	0.3	0.6	-0.2	0.8
Prostate Cancer	0.2	0.3	0.6	-0.8	0.0
Age at First Birth	0.2	0.3	0.3	0.6	0.5
Systolic Blood Pressure	0.2	0.8	1.4	0.5	1.2
Hand grip strength (left)	0.2	0.5	0.5	0.6	0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.3	0.5	0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.2	-0.4	0.5
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.7	0.4
Supplements: Glucosamine	0.2	0.2	0.3	0.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.2	-0.5	0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.5	0.2	0.7
Medication: Ramipril	0.2	0.2	0.3	-0.2	-0.6
Fluid intelligence score	0.2	0.5	0.6	-0.8	-0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.8	-0.0
Number of live births	0.2	0.3	0.5	0.3	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.8	0.8	0.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.4	0.6	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.1	-0.9
Suffer from ‘nerves’	0.2	0.3	0.7	-0.0	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	0.3	-0.7
Supplements: Vitamin C	0.2	0.3	0.5	0.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	1.0	-0.2
Average weekly red wine intake	0.2	0.3	0.5	-0.7	0.5
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	0.3	0.7
Ever taken oral contraceptive pill	0.2	0.3	0.4	0.3	-0.7
Mother’s age at death	0.2	0.3	0.5	-0.3	-0.7
Financial situation satisfaction	0.2	0.3	0.5	0.3	0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.7	0.0
Ever depressed for a whole week	0.2	0.3	0.3	-0.6	0.4
Depression (Nagel 2018)	0.1	0.2	0.2	0.4	0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	-0.7	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	0.0	-0.7
LDL Cholesterol	0.1	0.1	0.3	0.0	-0.5
Lupus	0.1	0.1	0.1	0.2	0.4
Blood White Count	0.1	1.0	1.8	1.4	-0.3
Hair Pigment	0.1	2.1	3.7	1.9	0.7
Tanning	0.1	1.0	1.7	1.3	0.5
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.7	0.1
Relative age of first facial hair	0.1	0.2	0.4	0.7	-0.0
Medication: Co-codamol	0.1	0.1	0.2	-0.5	0.1
Diabetes (mother)	0.1	0.1	0.2	0.1	-0.4
Severe depression (siblings)	0.1	0.2	0.2	0.4	0.4
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.2	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	0.4	0.3
Past tobacco smoking	0.1	0.1	0.2	-0.2	0.5
Hair/balding pattern: Pattern 2	0.1	0.2	0.2	0.4	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	-0.4	-0.3
Financial difficulties in last 2 years	0.1	0.1	0.1	0.4	-0.0
Heart attack	0.1	0.1	0.1	-0.4	0.1
Father’s age at death	0.1	0.1	0.1	0.2	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	0.3	-0.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	-0.5	-0.0
Tense / ‘highly strung’	0.1	0.2	0.3	0.3	0.6
Loud music exposure frequency	0.1	0.1	0.2	-0.0	-0.5
Number of children fathered	0.1	0.1	0.1	0.1	-0.3
Health satisfaction	0.1	0.1	0.1	-0.3	-0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.4	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.3	0.1
Number of full sisters	0.1	0.2	0.3	0.1	-0.5
Chest pain or discomfort	0.1	0.1	0.1	0.2	0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	-0.5
Loneliness, isolation	0.1	0.2	0.3	-0.2	0.5
Medication for cholesterol	0.1	0.1	0.1	0.3	-0.4
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.5	0.2
Miserableness	0.1	0.1	0.2	-0.5	0.0
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.2	-0.5
High cholesterol (Self-reported)	0.1	0.1	0.2	0.2	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.1	-0.2	-0.4
Risk taking	0.1	0.1	0.3	0.5	0.1
Age started oral contraceptive pill	0.1	0.1	0.3	-0.5	-0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.5	-0.0
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.0	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.2	0.0	-0.4
Fasting Glucose	0.0	0.0	0.0	-0.0	-0.1
Medication: Atenolol	0.0	0.0	0.0	-0.2	-0.2
Pain all over the body in last month	0.0	0.0	0.1	0.1	-0.2
Falls in the last year	0.0	0.0	0.1	-0.1	0.2
Happiness	0.0	0.0	0.0	0.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.2	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.1	0.1	0.1	0.3
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	-0.0	-0.1
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.1	0.3
Exposure to tobacco smoke outside home	0.0	0.0	0.1	-0.1	-0.3
Shortness of breath walking on level ground	0.0	0.0	0.0	0.1	-0.2
Alcohol intake frequency.	0.0	0.1	0.2	-0.4	0.1
Smoking status: Previous	0.0	0.1	0.1	0.2	-0.3
Long-standing illness, disability or infirmity	0.0	0.1	0.1	0.3	0.2
Commuting to job workplace: Walk	0.0	0.0	0.1	0.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	0.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.0	-0.2
Irritability	0.0	0.0	0.1	0.3	0.1
Cholesterol lowering medication	0.0	0.1	0.1	0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.1	-0.0	0.3

Hub : Genes

LOC541471

Models

Trait associations