TWAS hub - MIR4435-1HG

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.3170	0.0850	0.00011	0.096	NA	0.112	NA	0.096	0.00041	NA	0.00013	NA	0.00038
2	METSIM	Adipose	0.0278	0.0172	0.03400	-0.001	0.001	0.012	0.004	0.009	0.41000	0.19	0.00540	0.062	0.01500

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Red Count	5.1	49.6	98.6	0.8	-9.9
Osteoarthritis (self-reported)	5.0	6.5	10.0	-3.2	1.8
HbA1C	4.3	4.7	9.2	0.5	3.0
Fractured/broken bones in last 5 years	3.1	4.0	8.1	-0.1	2.8
Medication: Ibuprofen	2.8	3.3	5.0	-2.2	-1.3
Blood Platelet Count	2.6	30.4	45.6	-3.9	6.8
Schizophrenia vs Biploar Disorder	2.5	3.2	6.4	2.5	0.4
Emphysema/chronic bronchitis	2.5	2.8	3.6	-1.9	-1.4
Pain type(s) experienced in last month: Hip pain	2.4	3.1	5.9	-2.4	0.5
Medication: Atorvastatin	2.4	3.0	5.9	-0.3	-2.4
Alzheimer’s Disease (in father)	2.2	2.4	2.9	1.4	1.7
Crohns Disease (2012)	2.2	3.5	6.3	0.9	2.5
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.7	8.4	-1.0	-2.9
Back pain experienced in last month	2.2	3.2	6.2	-2.5	-0.4
Chronotype (morning person)	2.1	4.8	7.7	1.4	-2.8
Pulse wave reflection index	2.1	2.6	5.1	-0.1	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	3.1	1.8	-1.2
Pain all over the body in last month	2.0	2.1	3.8	-2.0	-0.7
Ever had prostate specific antigen (PSA) test	2.0	2.3	3.1	1.7	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	3.4	-1.9	-1.1
Birth weight of first child	1.9	3.5	6.0	2.4	-1.0
Ever had bowel cancer screening	1.9	2.3	3.1	1.2	-1.8
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	2.0	1.4	1.4
Coronary Artery Disease (CAD)	1.7	2.1	2.9	-1.7	-1.1
Fasting Glucose	1.7	2.0	3.9	-2.0	-0.4
Medication: Ventolin 100micrograms inhaler	1.7	2.1	2.6	-1.6	-1.3
Blood White Count	1.6	11.9	15.8	-4.0	-2.8
Diabetes (mother)	1.6	2.1	4.0	2.0	-0.4
High blood pressure (mother)	1.6	2.3	4.5	2.1	0.1
Asthma	1.6	3.1	6.1	-2.5	-0.4
Angina (self-reported)	1.6	2.1	2.6	-1.6	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.5	1.9	-0.6
Bipolar Disorder (2011)	1.5	1.4	2.1	-1.4	0.9
Rheumatoid Arthritis	1.5	2.1	2.4	1.6	1.3
Pack years adult smoking proportion	1.5	2.3	4.5	-0.4	-2.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.0	-0.6	-1.7
Ulcerative Colitis	1.4	2.1	3.9	2.0	-0.6
Angina	1.4	1.9	2.2	-1.5	-1.2
Medication: Ramipril	1.4	1.8	2.4	1.6	-1.1
Shortness of breath walking on level ground	1.4	1.6	3.0	-1.7	-0.5
Number of operations (self-reported)	1.4	2.1	3.0	1.1	-1.7
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.9	0.3	1.7
Cardiovascular Disease	1.3	4.2	4.9	2.2	-1.9
Breastfed as a baby	1.3	1.7	3.2	1.8	-0.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	1.9	-1.4	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	1.9	-1.1	-1.4
Pack years of smoking	1.3	1.9	3.7	-0.1	-1.9
Past tobacco smoking	1.2	2.2	3.4	-1.0	-1.8
High blood pressure (siblings)	1.2	1.7	3.2	1.8	-0.5
Smoking status: Previous	1.2	1.8	3.7	0.1	1.9
Asthma (self-reported)	1.2	2.3	4.5	-2.1	-0.4
Heart disease (siblings)	1.2	1.5	1.7	1.3	-1.1
Alzheimer’s Disease (including proxy)	1.1	1.7	2.3	1.0	1.5
Schizophrenia (2014)	1.1	2.5	4.8	2.2	0.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	1.3	1.1	1.2
Medication: Lansoprazole	1.1	1.2	2.3	-1.5	-0.3
Gout (self-reported)	1.1	1.5	2.2	1.0	1.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	1.7	1.3	-0.9
Wheeze or whistling in the chest in last year	1.1	1.9	3.7	-1.9	0.2
Mineral and other dietary supplements	1.1	1.4	1.7	1.1	-1.3
Mother’s age at death	1.1	1.4	2.8	-1.7	0.0
Myopia	1.1	1.6	2.6	-0.8	1.6
Alcohol drinker status: Previous	1.1	1.2	2.2	-0.5	1.5
Triglycerides	1.0	1.6	3.0	-1.7	0.4
Waist Hip Ratio (WHR)	1.0	4.6	5.6	2.4	1.9
High blood pressure	1.0	2.9	3.8	1.9	-1.4
Supplements: Glucosamine	1.0	1.3	1.3	-1.1	1.2
Qualifications: None of the above	1.0	2.1	3.0	-1.7	-1.1
Migraine (self-reported)	1.0	1.2	1.7	-0.8	1.3
Medication: Omeprazole	1.0	1.2	1.3	-1.0	-1.2
Commuting to job workplace: Public transport	1.0	1.2	2.3	-0.4	1.5
Average weekly spirits intake	0.9	1.1	2.2	-0.1	-1.5
Hearing difficulty/problems: Yes	0.9	1.4	2.0	-1.4	-0.9
Illnesses of siblings	0.9	1.2	2.3	-1.5	0.3
Qualifications: A levels/AS levels or equivalent	0.9	2.0	2.9	1.7	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.3	0.8	-1.2
Medication for pain relief, constipation, heartburn	0.9	1.5	2.9	1.7	-0.4
Hypertension (Self-reported)	0.9	2.5	2.5	1.6	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.9	-0.4	-1.4
Medication for cholesterol	0.9	1.4	2.2	-1.5	0.7
Medication: Paracetamol	0.9	1.4	2.3	-1.5	0.7
Age started oral contraceptive pill	0.9	1.2	2.3	-1.5	-0.2
Diastolic blood pressure, automated reading	0.9	2.9	3.8	1.4	-2.0
Pain experienced in last month	0.9	1.4	2.9	1.7	0.1
Breast Cancer	0.8	1.9	2.9	1.7	0.9
Relative age of first facial hair	0.8	1.6	2.1	1.1	-1.4
Heart attack	0.8	1.1	1.9	-0.5	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.5	-1.6	-0.2
Happiness	0.8	0.9	1.7	1.3	0.4
Lung cancer (father)	0.8	0.9	1.0	1.0	-0.8
Illnesses of mother	0.8	0.9	1.7	-1.3	-0.5
Pulse wave Arterial Stiffness index	0.8	0.9	1.3	1.1	-0.7
Glaucoma (self-reported)	0.8	1.0	1.7	1.3	0.6
Mean time to correctly identify matches	0.8	1.6	2.7	-0.7	1.6
Mood swings	0.8	1.4	2.1	-1.4	-0.8
Commuting to job workplace: Walk	0.8	0.9	1.6	1.3	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.6	-0.4	-1.3
Commuting to job workplace: Cycle	0.8	0.9	1.3	1.1	0.7
Vascular/heart problems diagnosed by doctor	0.8	2.2	3.2	-1.1	1.8
Ovarian Cancer	0.7	0.9	1.3	1.1	-0.8
Lung FEV1/FVC ratio	0.7	3.7	7.0	2.6	0.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	-0.3	1.2
Severe depression (siblings)	0.7	0.7	1.0	1.0	0.7
Average weekly fortified wine intake	0.7	0.9	1.0	-1.0	0.9
Depression (self-reported)	0.7	0.8	1.6	-1.2	0.3
Loud music exposure frequency	0.7	0.8	1.6	0.1	-1.3
Had major operations	0.7	0.8	1.6	1.3	0.3
Qualifications: nursing, teaching	0.7	1.1	2.2	1.5	-0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	1.4	-1.2	-0.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.5	0.5	-1.2
Medication: Blood pressure	0.7	1.3	1.9	1.4	-0.9
Medication: Bendroflumethiazide	0.7	1.0	2.0	1.4	0.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.7	-0.3	-1.3
Reaction Time	0.6	1.2	1.2	-1.1	1.1
Primary Biliary Cirrhosis	0.6	0.9	1.1	1.1	0.8
Systolic Blood Pressure	0.6	3.1	4.6	2.1	-1.2
Maternal smoking around birth	0.6	0.9	1.9	1.4	0.1
Hip circumference	0.6	2.4	3.9	-1.0	-2.0
Tense / ‘highly strung’	0.6	0.9	1.7	0.5	1.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	0.9	-1.0	0.7
Pulse wave peak to peak time	0.6	0.7	0.8	-0.9	0.8
Number of full sisters	0.6	0.7	1.2	1.1	-0.4
Medication: Aspirin	0.6	0.7	0.9	0.8	0.9
Supplements: Vitamin C	0.6	0.7	1.1	1.0	0.5
Number of self-reported non-cancer illnesses	0.6	1.0	1.9	-1.4	0.3
Average weekly champagne plus white wine intake	0.6	0.8	1.4	0.3	1.2
Wears glasses or contact lenses	0.6	0.7	0.7	-0.8	0.8
Medication: Lisinopril	0.6	0.8	0.9	1.0	0.8
Cholesterol lowering medication	0.6	0.9	1.0	0.8	-1.0
Depression (Nagel 2018)	0.5	0.8	1.2	1.1	-0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.2	0.4	1.5
Heel T-Score	0.5	4.1	6.1	-2.5	-1.5
Respiratory disease	0.5	1.2	1.8	-1.4	-0.7
Systolic blood pressure, automated reading	0.5	1.4	1.4	1.2	-1.2
Medication: Co-codamol	0.5	0.6	1.0	-1.0	0.4
Townsend deprivation index at recruitment	0.5	0.6	1.1	1.1	0.4
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.3	1.0	-1.1
Multivitamins +/- minerals	0.5	0.6	1.1	-1.1	-0.4
Medication: Atenolol	0.5	0.6	1.1	1.1	0.2
Chronic bronchitis/emphysema (father)	0.5	0.5	0.8	0.5	-0.9
Had other major operations	0.5	0.6	0.8	-0.9	-0.7
Financial difficulties in last 2 years	0.5	0.6	1.3	-1.1	-0.2
Worrier / anxious feelings	0.5	1.0	1.2	1.1	-0.9
Mouth/teeth dental problems: Dentures	0.5	0.8	1.6	-1.3	0.2
Prospective memory result	0.5	0.7	0.9	1.0	0.6
Exposure to tobacco smoke at home	0.5	0.6	0.9	-0.6	-0.9
Peak expiratory flow (PEF)	0.5	1.3	2.5	1.6	-0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.0	0.8	1.0
Medication: Paracetamol	0.5	0.7	1.1	-1.1	0.6
Eye problems/disorders: None of the above	0.5	0.5	0.5	0.7	-0.7
Neck or shoulder pain in last month	0.5	0.8	1.3	-0.4	-1.2
Chest pain or discomfort	0.5	0.8	1.0	-0.8	-1.0
Loneliness, isolation	0.5	0.7	1.2	-1.1	-0.4
Miserableness	0.5	0.9	1.3	-1.1	-0.8
Unable to work because of sickness or disability	0.5	0.7	1.2	0.4	-1.1
Medication for hormone replacement therapy	0.4	0.4	0.8	0.9	-0.3
Trunk fat percentage	0.4	1.8	2.6	-1.0	-1.6
Fed-up feelings	0.4	0.7	1.2	-0.5	-1.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.8	-0.9	0.1
Alcohol usually taken with meals	0.4	0.7	0.9	1.0	0.7
Nervous feelings	0.4	0.8	1.3	0.6	1.1
Allergy	0.4	1.0	2.0	-0.1	1.4
Medication: Simvastatin	0.4	0.6	1.2	-0.3	1.1
Fluid intelligence score	0.4	0.8	1.5	-0.3	1.2
Alcohol intake versus 10 years previously	0.4	0.5	1.0	-1.0	0.2
Father’s age at death	0.4	0.6	0.6	0.8	0.8
Blood clot in the leg (DVT)	0.4	0.5	0.8	0.3	-0.9
Number of children fathered	0.4	0.4	0.6	0.4	-0.8
Health satisfaction	0.4	0.5	0.8	0.9	-0.5
Qualifications: College or University degree	0.4	1.3	2.3	-0.6	1.5
Medication: Blood pressure	0.4	0.6	1.1	0.4	-1.1
Medication: Seretide 50 evohaler	0.4	0.5	1.0	-1.0	0.2
Heart disease (mother)	0.4	0.5	0.7	0.8	-0.5
Leg pain on walking	0.4	0.4	0.9	0.1	0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	0.0	1.0
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.8	0.2	0.9
Friendships satisfaction	0.4	0.5	0.9	-0.9	-0.3
Medication: Aspirin	0.4	0.5	0.6	0.7	0.8
Risk taking	0.4	0.5	0.6	-0.8	0.7
Ever depressed for a whole week	0.4	0.5	0.7	0.9	0.5
Supplements: Calcium	0.4	0.5	0.5	-0.7	0.7
Depressed Affect (Nagel 2018)	0.3	0.7	0.8	-0.9	-0.7
Crohns Disease (2017)	0.3	0.7	1.1	0.5	1.1
HDL Cholesterol	0.3	0.5	0.9	1.0	-0.3
Smoking Status	0.3	0.6	1.2	0.2	1.1
Hypothyroidism (self reported)	0.3	0.7	0.9	-0.8	-0.9
Vitamin and mineral supplements	0.3	0.4	0.7	0.8	-0.3
Medication: Metformin	0.3	0.5	0.6	-0.6	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-0.0	-0.9
Relative age voice broke	0.3	0.4	0.5	0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	0.1	1.1
Stomach or abdominal pain in last month	0.3	0.3	0.7	0.8	0.2
Trunk fat mass	0.3	1.2	2.1	-0.4	-1.5
Hearing difficulty/problems with background noise	0.3	0.4	0.8	-0.9	0.3
Arm fat percentage (right)	0.3	1.1	1.7	-0.7	-1.3
Hair/balding pattern: Pattern 3	0.3	0.5	0.5	-0.7	0.7
Noisy workplace	0.3	0.4	0.4	0.7	-0.6
Medication: Cholesterol lowering	0.3	0.4	0.9	-0.1	0.9
Length of working week for main job	0.3	0.3	0.4	0.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	1.0	0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.3	-0.8
Body fat percentage	0.3	1.3	2.0	-0.8	-1.4
Leg fat percentage (right)	0.3	0.9	1.4	-0.7	-1.2
Number of full brothers	0.3	0.4	0.9	0.9	0.0
Illnesses of siblings: Diabetes	0.3	0.4	0.4	-0.6	0.6
Arm fat percentage (left)	0.3	1.1	2.0	-0.4	-1.4
Long-standing illness, disability or infirmity	0.3	0.4	0.8	-0.9	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	0.9	-0.3
Alcohol drinker status: Never	0.3	0.3	0.4	-0.6	-0.5
Ever smoked	0.3	0.5	0.6	0.7	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.3	0.0	1.1
Worry (Nagel 2018)	0.2	0.5	1.0	1.0	0.1
Prostate Cancer	0.2	0.3	0.5	0.7	-0.4
LDL Cholesterol	0.2	0.4	0.5	-0.7	-0.5
Lupus	0.2	0.4	0.7	0.1	-0.8
Neuroticism (2016)	0.2	0.3	0.4	0.6	0.5
Blood Eosinophil Count	0.2	1.8	3.1	1.8	0.7
BMI	0.2	1.1	1.7	-0.7	-1.3
Allergy or Eczema	0.2	0.6	0.6	0.8	-0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.3	-0.4	0.5
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.6	0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.1	-0.6
Body mass index (BMI)	0.2	0.7	1.2	-0.6	-1.1
Hair/balding pattern: Pattern 2	0.2	0.2	0.3	0.4	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	0.1	0.8
Mouth/teeth dental problems	0.2	0.3	0.4	0.7	0.5
Diabetes (self-reported)	0.2	0.3	0.4	-0.6	0.5
Impedance of arm (right)	0.2	0.9	1.7	-1.3	-0.2
Time employed in main current job	0.2	0.2	0.4	0.6	-0.1
Number of live births	0.2	0.3	0.6	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.1	1.1	0.1
Worry too long after embarrassment	0.2	0.4	0.6	-0.4	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.6	0.2
Pulse rate, automated reading	0.2	0.6	1.1	1.0	-0.5
Alcohol intake frequency.	0.2	0.5	1.0	-1.0	-0.1
Family relationship satisfaction	0.2	0.2	0.5	0.0	0.7
Knee pain experienced in last month	0.2	0.3	0.4	-0.6	0.4
Breast cancer (self-reported)	0.2	0.2	0.5	0.0	0.7
Osteoporosis (self-reported)	0.2	0.3	0.6	-0.0	0.8
Financial situation satisfaction	0.2	0.2	0.3	0.4	-0.5
Leg fat percentage (left)	0.2	0.7	0.7	-0.8	-0.8
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	-0.7	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.3	-0.7
Impedance of whole body	0.2	0.9	1.6	-1.3	-0.5
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.6	-0.3
Schizophrenia (2018)	0.1	0.3	0.6	0.8	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.3	0.6	0.5
Ulcerative Colitis (UC)	0.1	0.3	0.4	0.6	-0.4
Age at First Birth	0.1	0.2	0.2	0.4	-0.4
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	-0.0
Mean Putamen Volume	0.1	0.1	0.1	-0.2	0.3
Height	0.1	1.1	2.1	1.4	0.4
Hand grip strength (left)	0.1	0.3	0.6	-0.8	0.2
Number of treatments/medications taken	0.1	0.2	0.2	-0.4	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.3	0.6	-0.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.0	-0.4
Supplements: Zinc	0.1	0.1	0.1	-0.3	-0.3
Diabetes (father)	0.1	0.2	0.4	0.6	0.1
Impedance of leg (right)	0.1	0.6	1.0	-1.0	-0.6
Age when periods started (menarche)	0.1	0.3	0.5	0.7	0.4
Medication: Levothyroxine sodium	0.1	0.1	0.1	-0.4	0.3
Sitting height	0.1	1.0	2.0	1.4	-0.2
Impedance of leg (left)	0.1	0.5	1.0	-1.0	-0.1
Waist circumference	0.1	0.2	0.4	-0.1	-0.6
Number of incorrect matches in round	0.1	0.1	0.3	0.0	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.3	-0.6
Had menopause	0.1	0.1	0.1	-0.4	0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.6	-0.0
Neuroticism score	0.1	0.2	0.4	-0.7	-0.0
Weight	0.1	0.4	0.7	0.2	-0.8
Trunk fat-free mass	0.1	0.8	1.6	1.3	-0.2
Pulse rate	0.1	0.2	0.2	0.4	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.4	0.7	0.1
Impedance of arm (left)	0.1	0.5	0.6	-0.8	-0.6
Arm fat mass (right)	0.1	0.6	1.0	-0.4	-1.0
Trunk predicted mass	0.1	0.8	1.5	1.2	-0.3
Standing height	0.1	1.2	2.4	1.6	0.0
Headache pain in last month	0.1	0.3	0.5	-0.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	-0.5	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.2	-0.4	-0.3
Medication: Amlodipine	0.1	0.2	0.2	0.5	-0.5
Birth weight	0.1	0.2	0.3	0.5	0.2
Arm fat-free mass (right)	0.1	0.5	1.0	1.0	-0.4
Comparative body size at age 10	0.1	0.3	0.3	0.4	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	-0.1
Age at first live birth	0.1	0.1	0.3	0.1	0.5
Medication: Allopurinol	0.1	0.1	0.2	0.1	0.5
Whole body fat mass	0.1	0.5	1.0	-0.1	-1.0
Arm predicted mass (right)	0.1	0.5	0.9	0.9	-0.3
Suffer from ‘nerves’	0.1	0.1	0.2	0.0	-0.4
Age at last live birth	0.1	0.2	0.3	-0.3	0.5
Whole body fat-free mass	0.1	0.4	0.8	0.9	-0.3
Average weekly red wine intake	0.1	0.2	0.3	0.5	0.3
Smoking status: Current	0.1	0.1	0.2	0.5	-0.1
Whole body water mass	0.1	0.5	0.8	0.9	-0.3
Arm fat mass (left)	0.1	0.5	0.9	-0.1	-1.0
Guilty feelings	0.1	0.2	0.3	-0.2	0.6
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.2	0.4
Hearing aid user	0.1	0.1	0.1	-0.3	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	0.3	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.2	0.4
High cholesterol (Self-reported)	0.1	0.2	0.3	0.6	0.2
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.6	-0.2
Basal metabolic rate	0.1	0.4	0.6	0.8	-0.5
Average weekly beer plus cider intake	0.1	0.2	0.2	-0.3	-0.5
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.2	-0.1
Neuroticism (Nagel 2018)	0.0	0.0	0.0	-0.2	-0.1
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.1	-0.0
Major Depression (MDD)	0.0	0.0	0.0	0.2	-0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	-0.1	0.3
Lung FVC	0.0	0.1	0.2	-0.4	-0.2
Neuroticism	0.0	0.0	0.1	0.3	-0.1
Hair Pigment	0.0	0.3	0.6	-0.1	-0.8
Tanning	0.0	0.5	0.8	-0.9	-0.4
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.0	-0.4
Ever had hysterectomy (womb removed)	0.0	0.1	0.1	0.2	0.3
Leg fat-free mass (left)	0.0	0.3	0.3	0.5	-0.5
Hand grip strength (right)	0.0	0.0	0.1	-0.2	-0.2
Current tobacco smoking	0.0	0.0	0.0	0.1	-0.1
Taking other prescription medications	0.0	0.1	0.1	-0.2	0.3
Leg predicted mass (left)	0.0	0.2	0.3	0.4	-0.5
Forced vital capacity (FVC)	0.0	0.0	0.0	-0.0	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.1	0.1
Falls in the last year	0.0	0.0	0.1	0.3	0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.3	-0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	-0.2	0.4
Exposure to tobacco smoke outside home	0.0	0.0	0.0	-0.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.1	0.1
Leg fat mass (right)	0.0	0.2	0.4	0.1	-0.6
Comparative height size at age 10	0.0	0.1	0.2	0.4	0.1
Overall health rating	0.0	0.1	0.2	-0.1	-0.4
Illnesses of father: Heart disease	0.0	0.1	0.1	0.3	-0.2
Leg fat-free mass (right)	0.0	0.3	0.5	0.7	-0.2
Diabetes diagnosed by doctor	0.0	0.1	0.1	0.1	0.3
Eye problems/disorders: Cataract	0.0	0.0	0.0	-0.0	0.1
Medication: Gliclazide	0.0	0.0	0.0	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	0.4	0.1
Leg predicted mass (right)	0.0	0.2	0.4	0.7	-0.2
Arm fat-free mass (left)	0.0	0.2	0.4	0.6	-0.3
Irritability	0.0	0.1	0.1	-0.3	-0.2
Leg fat mass (left)	0.0	0.1	0.2	-0.1	-0.5
Arm predicted mass (left)	0.0	0.2	0.3	0.5	-0.3

Hub : Genes

MIR4435-1HG

Models

Trait associations