TWAS hub - BCL2L11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0400	0.0200	7.0e-03	0.041	0.008	0.022	0.01	0.028	9.4e-06	0.0320	8.1e-04	0.019	0.00020
2	GTEx	Adrenal Gland	0.2134	0.0753	3.7e-04	0.050	NA	0.125	NA	0.096	6.9e-03	NA	3.2e-05	NA	0.00025
3	GTEx	Colon Transverse	0.2210	0.0760	1.2e-03	0.040	NA	0.026	NA	0.051	5.5e-03	NA	2.0e-02	NA	0.00190
4	GTEx	Esophagus Mucosa	0.1010	0.0420	4.4e-03	0.001	NA	0.018	NA	0.003	2.7e-01	NA	2.2e-02	NA	0.20000
5	GTEx	Thyroid	0.0860	0.0370	7.4e-03	0.001	NA	-0.003	NA	-0.001	2.6e-01	NA	6.5e-01	NA	0.39000
6	TCGA	Colon Adenocarcinoma	0.0700	0.0330	8.7e-05	0.013	0.061	0.037	NA	0.026	5.3e-02	0.0002	3.3e-03	NA	0.01200
7	TCGA	Prostate Adenocarcinoma	0.0445	0.0288	5.4e-03	0.018	0.004	0.016	NA	0.017	5.0e-03	0.1200	8.2e-03	NA	0.00570

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood Red Count	6.4	61.7	131.9	-5.6	-3.1	-2.4	-9.1	-7.9	-10.4	-11.5
Medication: Metformin	6.4	9.0	19.3	4.4	3.2	-1.9	1.6	-1.2	3.5	3.6
Lung cancer (father)	6.3	7.3	14.9	3.3	2.9	0.6	2.0	0.1	3.5	3.9
Diabetes (self-reported)	6.1	9.4	23.0	4.8	3.0	-1.2	1.6	-1.1	3.7	3.9
Had major operations	6.1	7.2	14.1	-3.8	-2.4	1.3	-2.0	0.5	-3.4	-3.5
Number of operations (self-reported)	5.3	7.8	15.4	-3.7	-2.3	-0.3	-2.7	0.2	-3.9	-3.5
Myopia	5.2	7.5	11.2	2.6	3.4	-0.1	2.9	3.1	3.0	2.6
Migraine (self-reported)	5.0	6.2	17.0	-3.2	-2.1	-0.7	-1.5	0.2	-2.9	-4.1
Diabetes diagnosed by doctor	4.9	8.0	19.4	4.4	2.5	-1.5	1.4	-0.8	3.4	3.7
Birth weight	4.6	10.0	21.8	-4.7	-3.7	0.2	-2.2	0.6	-4.1	-3.6
Eye problems/disorders: Cataract	4.1	4.8	8.4	2.2	2.8	-0.9	2.6	2.9	2.0	0.9
Breast Cancer	3.8	9.0	17.4	1.3	1.8	4.2	3.0	3.3	2.9	3.5
Type 2 Diabetes (T2D) (2018)	3.6	6.7	15.6	4.0	2.6	-1.2	1.1	-1.0	3.0	3.4
Pulse rate, automated reading	3.6	11.6	22.8	4.8	3.4	-4.3	1.8	-0.1	4.0	3.0
Leg fat-free mass (right)	3.5	18.7	40.4	-6.4	-5.2	3.0	-2.5	0.2	-5.3	-4.5
Leg fat-free mass (left)	3.4	18.3	39.8	-6.3	-5.0	3.1	-2.5	0.4	-5.2	-4.4
Leg predicted mass (left)	3.4	18.0	39.6	-6.3	-5.0	3.1	-2.4	0.6	-5.1	-4.4
Leg predicted mass (right)	3.4	18.0	39.3	-6.3	-5.1	2.9	-2.4	0.2	-5.2	-4.4
Medication: Paracetamol	3.4	5.3	9.7	-2.7	-3.1	-0.8	-2.2	2.0	-2.8	-1.7
Coronary Artery Disease (CAD)	3.3	4.0	6.6	-1.2	-2.0	-2.3	-2.2	1.0	-2.6	-2.2
Hip circumference	3.3	14.1	27.6	-5.2	-4.8	4.5	-2.1	-0.6	-4.0	-2.6
Whole body fat-free mass	3.3	18.7	35.4	-6.0	-4.8	3.4	-3.1	0.3	-5.0	-5.1
Basal metabolic rate	3.3	18.0	35.8	-6.0	-4.7	3.5	-2.8	0.1	-5.0	-4.7
Trunk predicted mass	3.1	17.8	30.8	-5.5	-4.3	3.5	-3.6	0.3	-4.8	-5.3
Whole body water mass	3.1	17.9	34.0	-5.8	-4.6	3.4	-3.0	0.2	-4.9	-5.0
Trunk fat-free mass	3.0	17.4	30.1	-5.5	-4.2	3.5	-3.6	0.3	-4.7	-5.2
Medication: Paracetamol	2.9	4.8	8.1	-2.6	-2.8	-0.2	-2.2	2.2	-2.7	-1.1
Ovarian Cancer	2.8	3.7	8.1	2.0	0.8	-1.2	1.9	0.6	2.8	2.8
Type 2 Diabetes (T2D) (2012)	2.8	3.3	12.2	1.4	1.5	-0.1	1.4	-0.1	2.1	3.5
Had menopause	2.8	3.4	6.4	2.1	1.3	-1.0	2.5	1.1	2.4	1.9
Arm fat-free mass (right)	2.8	14.6	24.7	-5.0	-4.3	3.0	-3.0	-0.2	-4.3	-4.7
Crohns Disease (2017)	2.7	6.0	9.6	3.1	2.6	1.4	1.3	2.8	2.6	2.8
Crohns Disease (2012)	2.7	4.4	6.2	2.5	2.4	0.9	2.1	2.2	2.1	2.1
Weight	2.7	13.4	29.5	-5.4	-4.4	3.2	-2.0	-0.2	-4.5	-3.1
Birth weight of first child	2.7	4.9	10.1	-3.2	-2.0	1.2	-0.9	1.0	-2.9	-2.9
Peak expiratory flow (PEF)	2.7	6.3	10.7	-3.0	-2.2	1.7	-1.8	-1.6	-3.3	-3.3
Arm predicted mass (right)	2.7	13.7	23.2	-4.8	-4.0	3.0	-3.0	-0.1	-4.2	-4.6
Diabetes (father)	2.5	3.1	6.1	1.4	2.0	1.5	2.1	0.1	2.5	1.7
Hearing aid user	2.5	2.8	4.1	-1.8	-1.8	-2.0	-0.9	1.8	-1.4	-1.8
Sitting height	2.4	17.1	34.6	-5.9	-4.0	1.8	-2.7	1.7	-5.5	-5.2
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.7	4.7	-2.2	-2.0	1.0	-2.1	-0.3	-1.8	-1.3
Pulse wave reflection index	2.4	3.0	5.3	-2.3	-2.0	0.0	-1.5	0.7	-1.9	-2.3
Arm fat-free mass (left)	2.4	12.3	22.2	-4.7	-3.7	3.3	-2.7	-0.3	-4.0	-4.1
Arm predicted mass (left)	2.4	12.4	22.2	-4.7	-3.6	3.2	-2.9	-0.3	-3.9	-4.2
Blood Platelet Count	2.3	27.2	55.2	7.0	4.2	-5.3	2.3	1.3	5.8	7.4
Impedance of leg (left)	2.3	11.2	22.5	4.7	4.7	-2.1	2.5	-0.2	3.5	3.2
Forced expiratory volume in 1-second (FEV1)	2.3	7.6	14.3	-3.8	-2.4	2.2	-1.5	-0.9	-3.5	-3.6
Eye problems/disorders: None of the above	2.3	2.6	8.4	-1.2	-1.7	2.1	-1.1	-2.9	-0.5	0.2
Forced vital capacity (FVC)	2.2	8.3	14.4	-3.8	-2.7	1.5	-2.6	-0.0	-3.7	-3.7
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	7.6	-2.8	-2.3	-0.7	-0.5	-0.1	-2.2	-0.7
Ever used hormone-replacement therapy (HRT)	2.1	2.7	6.3	2.3	2.0	-0.1	0.0	0.3	2.5	1.7
Impedance of leg (right)	2.1	10.3	22.0	4.5	4.7	-2.0	2.4	0.2	3.5	2.8
Medication: Ibuprofen	2.1	2.5	5.8	-2.3	-2.4	-1.1	-0.7	0.4	-1.9	-0.7
Medication: Gliclazide	2.1	2.3	5.9	2.4	1.1	-1.8	-0.0	-0.4	1.7	1.8
Financial situation satisfaction	2.1	2.6	7.6	-1.4	-1.3	-0.6	-0.7	-1.7	-1.7	-2.7
Medication: Allopurinol	2.0	2.7	6.2	2.1	1.3	-0.6	1.1	0.6	2.5	2.2
Illnesses of siblings: Diabetes	2.0	2.4	6.6	1.8	1.9	0.6	0.4	-0.9	1.5	2.6
Vitamin and mineral supplements	1.9	2.5	4.8	1.6	1.2	0.2	1.4	-1.5	2.2	2.1
Father’s age at death	1.9	2.5	9.7	-0.7	0.9	3.1	2.4	-0.2	0.7	-0.3
Pulse rate	1.9	3.2	7.5	2.6	1.8	-2.7	0.5	-0.1	2.1	0.8
Arm fat mass (right)	1.9	7.8	18.7	-4.3	-3.5	2.6	-1.1	-0.1	-3.5	-1.8
Arm fat mass (left)	1.9	8.0	19.1	-4.4	-3.5	2.9	-0.7	-0.2	-3.4	-2.0
Age started oral contraceptive pill	1.9	2.4	6.1	0.9	1.1	0.4	2.5	0.8	1.9	2.0
Prostate Cancer	1.8	2.6	11.2	1.0	0.9	-1.9	-0.2	-1.1	0.0	-3.3
Waist Hip Ratio (WHR)	1.8	8.1	43.0	2.2	2.4	-6.6	0.6	-1.5	0.5	-0.5
Hearing difficulty/problems: Yes	1.8	2.7	7.9	-2.0	-2.8	0.4	-1.3	0.0	-1.6	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.7	10.6	-2.7	-1.6	3.1	-1.8	-0.6	-2.6	-3.3
Comparative height size at age 10	1.8	9.9	18.6	-4.3	-3.6	0.6	-2.6	0.9	-4.2	-3.5
Eye problems/disorders: Glaucoma	1.8	2.1	6.5	-0.2	0.2	-1.4	-2.6	0.5	-1.3	-2.1
Trunk fat mass	1.7	7.3	19.2	-4.4	-3.3	2.0	-0.4	0.3	-3.7	-1.8
Medication: Lansoprazole	1.7	1.9	5.6	1.1	0.9	-0.5	2.4	-0.5	1.9	1.3
Breast cancer (self-reported)	1.7	2.0	10.8	1.0	1.2	-3.3	0.0	0.6	0.2	-0.6
Medication: Bendroflumethiazide	1.7	2.5	7.5	-0.4	-1.4	-2.7	-1.8	-1.1	-1.4	-1.4
Supplements: Calcium	1.7	1.9	6.8	0.1	-0.0	1.0	1.3	1.3	1.4	2.6
Medication for hormone replacement therapy	1.6	1.8	4.7	2.2	0.9	-0.4	-0.8	-1.3	1.3	1.6
Waist circumference	1.6	5.8	13.5	-3.7	-3.2	0.4	-1.2	-0.7	-3.2	-2.2
Number of live births	1.6	2.3	4.8	-0.6	-1.1	-1.9	-2.2	-0.5	-1.1	-2.1
Blood clot in the leg (DVT)	1.6	2.0	3.9	-2.0	-1.2	0.6	-1.6	-0.5	-1.6	-1.7
Medication for pain relief, constipation, heartburn	1.6	2.8	5.7	2.2	1.7	1.5	0.7	-0.7	2.4	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	5.7	1.6	1.1	0.3	1.3	-0.7	1.4	2.4
Whole body fat mass	1.6	6.6	17.0	-4.1	-3.2	2.3	-0.3	-0.0	-3.3	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	5.9	0.7	2.4	1.1	2.0	-0.9	0.8	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.6	-1.2	-1.5	-0.5	-1.9	0.9	-1.5	-1.0
Diastolic blood pressure, automated reading	1.6	4.8	9.0	-2.7	-2.4	-1.5	-2.0	0.3	-2.4	-3.0
Major Depression (MDD)	1.5	1.8	3.3	-1.8	-1.0	0.8	-0.9	1.4	-1.5	-1.6
Relative age of first facial hair	1.5	3.0	14.4	-1.8	-0.3	1.3	-1.1	0.3	-0.8	-3.8
Ever had hysterectomy (womb removed)	1.5	1.7	5.0	1.0	0.3	-2.2	-1.0	-1.5	0.4	1.6
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.9	1.5	1.0	-0.6	1.5	-0.3	1.3	2.0
Standing height	1.5	14.8	30.4	-5.5	-3.2	2.3	-2.4	0.8	-5.2	-4.9
Leg pain on walking	1.5	1.9	4.0	-1.9	-1.5	1.1	-2.0	-0.8	-1.4	-0.3
Knee pain experienced in last month	1.5	2.3	6.1	-1.3	-2.5	0.8	-2.1	1.2	-1.4	-0.1
Friendships satisfaction	1.5	1.9	4.0	-1.5	-1.3	-0.1	-1.3	-1.3	-2.0	-1.4
Heel T-Score	1.4	11.1	20.2	-4.4	-3.7	-2.2	1.5	-0.6	-4.1	-4.5
Headache pain in last month	1.4	2.4	5.2	-2.1	-1.1	-0.5	-1.1	-0.7	-2.3	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.0	-1.5	-1.7	0.8	-1.2	1.2	-1.5	-0.5
Illnesses of father: Heart disease	1.4	2.0	8.4	-1.6	-2.9	-0.3	-0.3	-0.5	-1.5	-0.7
Arm fat percentage (left)	1.4	5.7	14.7	-3.8	-3.1	2.1	-0.2	-0.6	-3.1	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	4.5	-1.3	-1.2	-0.8	-0.5	2.1	-1.0	-1.4
Hypothyroidism (self reported)	1.3	2.9	7.6	2.1	1.0	0.0	2.8	0.4	2.1	1.6
Taking other prescription medications	1.3	2.0	6.8	0.8	0.6	-2.6	1.0	2.1	0.9	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	5.4	-2.3	-2.1	-1.5	0.1	0.8	-2.0	-2.0
Arm fat percentage (right)	1.3	5.1	13.4	-3.7	-2.9	2.2	-0.2	-0.5	-2.9	-0.9
Length of working week for main job	1.3	1.4	3.3	-1.5	-1.8	1.8	0.3	0.3	-0.9	0.2
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.1	-1.4	-1.5	0.4	-1.8	-1.4	-1.4	-0.5
Age at last live birth	1.3	1.9	11.5	0.2	-0.8	-0.9	-3.4	0.1	-0.6	-0.1
Mineral and other dietary supplements	1.3	1.8	3.6	1.9	1.1	0.4	0.3	-1.6	1.7	1.4
Medication: Aspirin	1.3	1.6	4.0	1.4	1.6	-2.0	0.1	-1.1	1.1	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.8	-2.0	-0.9	0.4	-1.3	0.1	-1.5	-1.7
Schizophrenia (2018)	1.2	2.5	5.4	-2.3	-2.2	0.7	-0.8	0.7	-1.7	-1.7
Systolic blood pressure, automated reading	1.2	3.5	5.6	-1.8	-2.3	-1.7	-1.9	0.4	-1.8	-2.4
Hand grip strength (right)	1.2	3.2	7.8	-1.4	-2.0	-0.6	-2.8	-0.6	-2.8	-0.8
High blood pressure (mother)	1.2	1.6	2.9	-0.5	-1.7	1.7	-1.1	-1.5	-0.9	-1.2
Body mass index (BMI)	1.2	5.2	10.9	-3.3	-3.3	2.3	-1.1	-0.7	-2.6	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.6	5.2	-2.1	-2.3	-1.6	0.5	0.4	-1.8	-1.7
Noisy workplace	1.2	1.4	3.3	-1.4	-1.8	-0.5	-1.4	-0.4	-1.5	-0.3
Exposure to tobacco smoke at home	1.2	1.4	2.7	1.1	1.6	1.3	0.8	0.9	1.6	-0.0
Forced vital capacity (FVC), Best measure	1.2	4.5	9.0	-2.4	-1.2	2.6	-1.8	0.0	-2.3	-3.0
Comparative body size at age 10	1.2	3.3	7.6	-2.8	-2.7	1.6	0.1	0.7	-2.0	-1.1
Number of full brothers	1.2	1.5	3.0	-1.1	-0.6	0.0	-1.5	-1.4	-1.4	-1.7
Family relationship satisfaction	1.2	1.4	2.2	-1.4	-1.3	-0.7	-1.5	0.7	-1.2	-1.3
Impedance of whole body	1.2	6.2	11.6	2.8	3.4	-2.1	2.8	0.5	2.1	2.7
Ulcerative Colitis (UC)	1.1	2.0	4.5	-1.8	-1.2	1.2	-2.1	0.1	-1.7	-0.6
Rheumatoid Arthritis	1.1	1.5	3.9	-2.0	-1.6	1.2	-0.9	1.3	-0.6	0.4
Height	1.1	22.0	44.5	-6.7	-4.2	2.3	-3.1	0.9	-6.0	-6.3
Diabetes (mother)	1.1	1.3	4.7	0.8	0.1	1.0	-1.7	-2.2	0.2	0.4
Prospective memory result	1.1	1.4	4.3	-0.8	-2.1	0.2	-0.7	-1.1	-1.6	-0.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.6	1.6	1.6	-0.1	0.7	1.2	1.3	1.0
Commuting to job workplace: Walk	1.1	1.2	6.2	-1.2	0.0	2.5	-0.4	-0.5	-0.5	-0.2
Wears glasses or contact lenses	1.1	1.2	3.5	1.3	0.8	-1.2	0.9	1.9	0.6	0.7
Triglycerides	1.0	1.6	3.8	2.0	0.9	-1.5	1.5	-0.6	1.1	1.0
Blood Eosinophil Count	1.0	7.3	20.1	-1.6	-3.8	2.4	-2.7	-0.2	-1.2	4.5
Smoking Status	1.0	2.4	6.5	2.1	2.6	0.1	-1.1	1.5	1.5	0.4
Breastfed as a baby	1.0	1.2	3.1	1.1	1.6	0.4	0.6	-0.2	1.8	1.0
Gout (self-reported)	1.0	1.4	4.0	1.3	0.2	0.0	0.5	0.6	2.0	1.9
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.5	1.1	1.3	1.4	-0.1	-0.7	1.6	-0.3
Leg fat mass (right)	1.0	3.9	9.1	-3.0	-2.1	2.7	0.1	-0.5	-2.2	-1.0
Alcohol drinker status: Never	1.0	1.2	3.8	1.4	-0.4	-0.5	-1.3	-0.0	0.7	2.0
Bipolar Disorder or Schizophrenia	0.9	2.2	5.1	-2.2	-2.0	1.2	-0.4	-0.9	-1.5	-1.4
BMI	0.9	5.5	12.3	-3.5	-2.8	3.1	-1.0	-0.5	-2.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.1	-1.3	-1.4	-1.1	-1.3	0.1	-1.2	-0.5
Angina	0.9	1.1	3.4	1.3	0.9	-1.8	0.8	-0.5	1.0	-0.3
Trunk fat percentage	0.9	3.5	10.0	-3.2	-2.3	1.3	0.7	0.3	-2.7	-0.4
Multivitamins +/- minerals	0.9	1.2	3.2	-1.2	-0.6	0.2	-1.0	0.6	-1.8	-1.3
Stomach or abdominal pain in last month	0.9	1.1	2.8	-0.7	0.3	1.6	1.3	-1.7	-0.1	0.0
Alcohol usually taken with meals	0.9	1.5	3.1	0.9	1.4	1.8	1.7	-0.1	1.3	0.5
Financial difficulties in last 2 years	0.9	1.2	2.7	-0.2	-0.6	-1.5	-1.0	-1.6	-1.2	-0.9
Medication: Cholesterol lowering	0.9	1.4	3.4	1.6	0.9	-1.9	0.5	1.0	0.9	0.8
Angina (self-reported)	0.9	1.1	3.5	1.3	0.9	-1.9	0.7	-0.6	1.0	-0.4
Medication: Aspirin	0.9	1.2	2.0	1.0	1.4	-1.4	0.6	-1.1	0.8	-1.2
Osteoarthritis (self-reported)	0.9	1.2	4.1	-1.3	-0.6	-0.9	-0.3	2.0	-0.6	-1.1
Leg fat mass (left)	0.9	3.6	8.5	-2.9	-2.2	2.5	0.1	-0.5	-2.1	-0.8
Irritable Bowel Disease (IBD)	0.8	1.8	3.4	0.9	1.1	1.8	0.0	1.8	0.9	1.9
Body Mass Index (BMI) (2010)	0.8	1.0	1.8	-1.1	-1.2	0.6	-1.1	1.2	-1.3	-0.0
Primary Biliary Cirrhosis	0.8	1.2	2.7	0.9	1.1	0.4	1.6	-1.1	0.6	-1.3
Systolic Blood Pressure	0.8	4.1	9.9	-0.5	-1.6	-3.1	-1.9	-1.1	-1.2	-3.1
Respiratory disease	0.8	1.9	7.9	1.3	0.3	-0.6	1.2	-0.2	1.2	2.8
Lung FEV1/FVC ratio	0.8	4.3	11.0	0.7	2.6	2.8	1.5	-3.3	0.8	-0.9
Serious illness, injury or assault to yourself	0.8	1.0	2.3	-0.2	-0.8	-1.5	-1.1	0.9	-0.7	-1.1
Supplements: Glucosamine	0.8	1.0	2.9	-0.5	0.2	-0.6	-1.4	1.7	-0.9	-0.9
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	5.4	-0.3	-1.0	-0.3	-0.3	2.3	-0.2	-0.2
Number of incorrect matches in round	0.8	1.3	2.1	1.3	1.3	-0.0	0.8	-1.4	0.9	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	3.7	-1.3	-0.8	-0.3	0.1	-1.2	-1.1	-1.9
Hearing difficulty/problems with background noise	0.8	1.3	2.3	-1.3	-1.5	-0.9	-1.5	0.6	-1.1	-0.8
Heart attack	0.8	1.1	3.6	0.4	0.1	-1.9	0.8	-1.8	0.0	0.3
Glaucoma (self-reported)	0.8	1.0	2.0	0.9	1.0	-1.1	-1.4	1.2	0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.5	1.4	0.3	1.1	1.9	0.4	1.5	1.0
Body fat percentage	0.8	3.3	9.1	-3.0	-2.3	1.6	0.5	-0.1	-2.4	-0.4
Neck or shoulder pain in last month	0.8	1.1	3.1	-1.8	-1.6	0.7	-0.1	-0.1	-1.2	-0.4
Medication: Omeprazole	0.8	1.0	2.3	-1.2	-0.9	-1.0	-0.6	0.4	-1.5	-1.0
Smoking status: Previous	0.8	1.2	4.0	-0.1	0.8	-0.4	-2.0	2.0	-0.2	-0.1
Ever taken oral contraceptive pill	0.8	0.9	1.9	0.1	1.1	1.4	1.4	-0.4	0.9	0.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.8	-1.7	-1.1	1.3	0.2	0.6	-0.9	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.2	-1.2	-0.7	-1.2	-0.6	-0.7	-1.5	-0.8
Basal cell carcinoma (self-reported)	0.8	1.0	1.9	-0.8	-1.0	-1.4	-0.0	-1.1	-0.8	-1.2
Heart attack/myocardial infarction (self-reported)	0.8	1.1	3.0	0.6	0.1	-1.7	1.1	-1.6	0.3	0.5
Heart disease (siblings)	0.8	1.0	3.0	-0.2	-1.0	-1.4	-0.0	-1.7	-1.1	-0.3
Bipolar Disorder (2018)	0.7	1.1	5.4	-0.7	-0.4	1.0	0.8	-2.3	-0.2	-0.2
Bipolar Disorder (2011)	0.7	0.7	2.7	-1.1	-1.6	-0.6	0.0	-0.4	-0.5	0.0
Blood White Count	0.7	4.8	15.9	1.6	0.4	-4.0	-0.4	-3.4	-0.3	-1.9
Severe depression (siblings)	0.7	0.7	1.7	-1.1	-0.6	-0.4	0.6	-1.0	-0.6	-1.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	0.6	1.5	-0.7	-0.5	-0.4	0.9	1.3
Past tobacco smoking	0.7	1.2	3.6	-0.5	-1.5	0.5	1.9	-1.4	-0.3	0.3
Time employed in main current job	0.7	0.8	1.8	-0.6	-1.3	1.2	-0.7	1.2	-0.3	0.5
Asthma	0.7	1.4	4.4	1.2	-0.6	-1.2	0.2	-1.2	0.7	2.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.8	-1.1	-0.3	-0.7	0.2	-0.6	-1.1	-1.7
Medication: Amlodipine	0.7	1.0	3.6	0.1	-0.6	-1.9	0.3	-1.1	-0.4	-1.2
Emphysema/chronic bronchitis	0.7	0.8	2.7	-0.3	0.4	-1.6	0.2	0.6	-0.9	-1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	-0.2	-1.2	-1.4	0.4	-1.2	-0.6	0.4
Average weekly red wine intake	0.7	1.1	2.5	-1.6	-0.1	1.1	-0.2	0.6	-1.2	-1.4
Mood swings	0.7	1.4	3.8	-0.7	-2.0	-1.4	-0.1	1.5	-0.7	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	3.9	0.5	0.9	-0.5	0.4	-2.0	1.0	-1.4
Asthma (self-reported)	0.7	1.4	4.3	1.4	-0.3	-1.1	-0.1	-1.4	0.8	2.1
Illnesses of father: None of the above (group 1)	0.7	0.9	3.1	0.7	1.8	-0.3	0.6	1.3	0.6	0.2
Number of self-reported non-cancer illnesses	0.7	1.3	5.5	0.8	0.3	-2.4	0.4	1.4	0.8	0.0
Illnesses of father: High blood pressure	0.7	0.9	4.3	-0.8	-2.1	0.2	-0.4	-0.8	-0.4	-0.6
Irritability	0.7	1.2	4.4	0.3	-0.1	0.1	1.3	2.1	1.1	0.8
HbA1C	0.6	0.7	1.5	0.1	0.5	-0.7	-0.6	1.2	-0.7	-1.2
Neuroticism (2016)	0.6	0.9	4.0	-0.7	-0.4	-1.0	0.4	2.0	-0.3	-0.4
Schizophrenia (2014)	0.6	1.4	3.5	-1.9	-1.3	0.8	-0.6	-0.7	-1.0	-1.4
Cardiovascular Disease	0.6	2.1	6.8	1.1	-0.6	-2.6	-1.2	-2.0	0.3	-0.8
Hand grip strength (left)	0.6	1.6	4.9	-0.5	-1.4	-1.1	-2.2	-0.3	-1.5	0.3
Average weekly spirits intake	0.6	0.8	2.0	-0.1	0.5	-1.1	-1.4	-1.4	-0.4	0.1
Age when periods started (menarche)	0.6	1.5	3.8	-2.0	-0.6	1.2	0.0	0.3	-1.5	-1.6
Had other major operations	0.6	0.8	2.4	-0.3	-0.8	-1.5	-0.6	-0.4	-1.3	-0.5
Medication: Simvastatin	0.6	0.9	3.0	1.1	0.4	-1.7	0.3	0.8	0.2	1.2
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.5	-1.3	-0.3	1.9	-0.1	-0.5	-0.8	-0.6
Number of full sisters	0.6	0.7	2.2	0.1	0.7	1.5	1.4	-0.4	0.1	0.5
Ever had bowel cancer screening	0.6	0.6	2.2	-0.2	-0.2	-1.5	0.6	1.1	0.1	0.8
Medication for cholesterol	0.6	0.9	4.1	-1.0	-0.4	0.7	0.4	2.0	-0.5	0.3
Medication: Blood pressure	0.6	1.1	2.2	-0.7	-1.5	-1.0	0.3	-1.3	-0.4	-1.4
Ever smoked	0.6	1.0	3.5	0.9	1.9	-0.0	-1.3	0.7	0.8	-0.4
Fractured/broken bones in last 5 years	0.6	0.8	1.7	0.9	0.1	0.1	1.3	1.1	0.9	1.1
Cholesterol lowering medication	0.6	0.9	4.0	0.5	-0.3	-0.9	-0.8	-2.0	-0.5	0.0
Pain experienced in last month	0.6	1.0	1.9	1.4	1.2	-1.1	0.1	-0.8	1.0	0.6
Number of treatments/medications taken	0.5	0.9	4.1	-0.0	-0.5	-2.0	-0.6	1.0	-0.4	-0.4
Sensitivity / hurt feelings	0.5	0.8	1.8	1.2	0.1	-1.0	-1.4	-0.6	1.0	0.0
Current tobacco smoking	0.5	0.8	3.2	1.0	1.8	0.4	-0.5	-0.1	1.0	-0.3
Pain all over the body in last month	0.5	0.6	1.5	0.7	0.7	-0.3	0.9	0.4	1.2	0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.2	-0.8	-0.7	0.5	-0.2	0.7	-0.3	-1.5
Medication: Ramipril	0.5	0.7	2.7	0.7	0.6	0.3	1.6	0.1	1.0	0.4
Illnesses of siblings	0.5	0.7	2.5	-1.2	-0.4	0.3	-0.5	1.6	-0.5	-0.4
Impedance of arm (right)	0.5	2.3	4.5	1.0	2.0	-1.3	2.1	1.1	0.5	1.8
Alcohol intake versus 10 years previously	0.5	0.8	2.2	-0.9	-1.5	-0.8	0.0	0.6	-0.9	-0.7
Falls in the last year	0.5	0.7	2.6	0.7	0.5	0.1	-0.1	1.1	0.7	1.6
Mouth/teeth dental problems: Dentures	0.5	0.9	2.2	0.1	0.6	-1.2	1.3	1.5	0.4	-0.6
Impedance of arm (left)	0.5	2.4	5.9	0.9	1.9	-1.7	2.4	1.1	0.5	1.6
Hair/balding pattern: Pattern 4	0.5	1.2	4.1	-1.0	-0.6	-1.1	0.1	-2.0	-1.3	0.2
Wheeze or whistling in the chest in last year	0.5	0.8	2.5	-1.1	-1.6	-0.5	-0.9	-0.2	-0.6	-0.6
Medication: Blood pressure	0.5	0.8	3.2	1.2	-0.3	-1.8	-0.2	0.2	0.7	0.8
Mean time to correctly identify matches	0.5	1.0	1.9	1.0	1.0	0.1	1.1	1.4	1.2	0.8
Heart disease (mother)	0.5	0.6	1.2	-0.9	-0.9	0.7	1.1	-0.4	-0.5	0.2
Suffer from ‘nerves’	0.5	0.8	2.7	-1.0	-0.5	0.8	-0.2	-0.2	-1.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.2	-0.8	-0.1	0.2	-1.8	-0.8	-1.3	-1.2
Loneliness, isolation	0.5	0.7	2.3	0.2	-1.5	-0.1	-0.0	-1.5	0.2	-0.0
Smoking status: Current	0.5	0.8	2.4	1.2	1.5	0.4	-0.7	-0.0	1.1	0.1
Medication: Atorvastatin	0.5	0.7	2.3	1.5	0.6	-1.0	0.5	-0.5	0.7	0.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	6.0	-0.7	0.9	2.4	-0.3	1.4	-0.6	0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	-0.5	0.4	1.0	-0.7	-0.3	0.0	-1.2
Alzheimer’s Disease (in father)	0.4	0.5	1.1	0.3	0.8	1.0	0.2	0.5	0.5	1.0
Reaction Time	0.4	0.8	1.7	1.0	1.3	-0.0	0.8	0.9	1.1	0.6
Mean Putamen Volume	0.4	0.5	2.1	0.8	1.5	-0.5	-0.4	-0.1	0.6	-0.1
Fasting Glucose	0.4	0.5	1.1	0.8	0.1	-0.1	-1.1	-0.9	0.0	1.0
HDL Cholesterol	0.4	0.7	1.8	0.9	1.3	0.7	0.4	0.7	0.9	0.3
Ulcerative Colitis	0.4	0.6	2.0	-0.8	-0.5	1.4	-1.1	-0.1	-0.6	0.0
Lung FVC	0.4	2.3	4.0	-1.5	-1.4	0.3	-1.8	-0.9	-2.0	-1.9
Neuroticism	0.4	1.0	2.9	1.7	1.2	-0.1	0.3	-0.6	1.5	0.3
Chronotype (morning person)	0.4	0.9	2.6	1.1	0.2	-0.8	-1.1	-1.6	0.5	-0.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.7	-0.4	-0.8	0.9	0.5	-0.6	-0.4	-1.3
Pack years adult smoking proportion	0.4	0.6	1.8	-1.3	-1.3	-0.0	0.3	-0.6	-0.3	-0.7
Maternal smoking around birth	0.4	0.6	2.0	-1.4	-1.0	0.7	0.2	-0.1	-0.4	-0.6
Fed-up feelings	0.4	0.7	1.7	1.3	0.5	1.1	-0.1	-0.4	0.8	0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	1.1	1.0	0.2	-0.1	-0.3	0.1	0.5
High blood pressure	0.4	1.1	4.1	0.4	-1.3	-2.0	0.2	-1.0	0.4	-0.8
Mouth/teeth dental problems	0.4	0.6	2.6	0.8	0.7	1.6	0.1	0.2	0.7	0.4
Fluid intelligence score	0.4	0.8	1.7	1.3	1.1	-1.3	0.5	-0.3	0.7	0.1
Tense / ‘highly strung’	0.4	0.6	3.2	-0.1	-0.3	0.5	-1.0	-1.8	0.0	0.1
Loud music exposure frequency	0.4	0.4	1.0	1.0	0.6	-0.4	-0.9	0.5	0.1	-0.2
Leg fat percentage (right)	0.4	1.3	3.1	-1.6	-1.1	1.8	0.5	-0.8	-1.0	0.2
Worry too long after embarrassment	0.4	0.7	2.2	0.8	1.5	0.0	-1.2	0.1	1.0	-0.1
Number of children fathered	0.4	0.5	0.9	-0.7	-1.0	0.0	-0.7	-0.8	-0.8	-0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	-0.6	-0.6	-0.1	-0.9	-0.9	-0.6	0.7
Medication: Seretide 50 evohaler	0.4	0.5	1.1	-1.1	-1.0	-0.2	-0.6	-0.3	-0.8	0.5
Overall health rating	0.4	0.8	1.7	-1.3	-1.3	-0.3	-1.1	-0.4	-1.0	0.3
Chest pain or discomfort	0.4	0.6	1.2	0.2	-0.9	-1.1	-0.6	-0.7	-0.3	-1.1
Hypertension (Self-reported)	0.4	1.2	5.2	0.4	-1.3	-2.3	0.3	-0.6	0.4	-1.0
Qualifications: nursing, teaching	0.4	0.6	2.9	-0.6	-0.4	0.0	0.3	0.8	-0.3	-1.7
Back pain experienced in last month	0.4	0.6	1.8	0.7	1.0	-0.6	1.4	0.7	0.5	-0.2
Average weekly champagne plus white wine intake	0.4	0.5	1.9	0.5	0.4	-0.3	-1.4	-0.8	-0.4	0.7
Mother’s age at death	0.4	0.5	1.6	0.5	0.3	0.8	0.4	1.3	0.7	0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.2	0.6	0.1	0.2	1.1	0.9	1.1	-0.3
Medication: Lisinopril	0.4	0.5	2.3	-0.0	-1.0	0.0	-0.3	1.5	-0.1	-0.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.1	0.9	1.1	-0.3	-0.3	-0.1	1.0	0.0
Commuting to job workplace: Cycle	0.4	0.5	1.7	-0.7	0.7	1.3	-0.1	-0.1	-0.7	-0.5
Alcohol drinker status: Previous	0.4	0.4	0.8	0.6	0.3	0.2	0.2	0.8	0.9	0.9
Depressed Affect (Nagel 2018)	0.3	0.6	1.5	1.2	0.1	-0.3	0.5	0.5	1.0	0.9
Lupus	0.3	0.5	0.7	-0.7	-0.7	0.0	-0.5	-0.8	-0.8	0.8
Tanning	0.3	3.2	5.2	-1.8	-2.1	-0.5	-2.3	-0.8	-2.3	-1.9
Relative age voice broke	0.3	0.4	0.9	0.4	0.9	-0.1	0.9	0.8	0.5	-0.4
Qualifications: CSEs or equivalent	0.3	0.4	1.3	0.3	1.1	-0.1	-0.9	-0.0	-0.1	-0.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	-0.3	-0.7	-0.6	-0.8	-0.3	-0.8	0.0
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	1.1	0.1	-0.3	-0.5	-0.7	-0.4	0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	-0.8	-0.6	0.4	0.5	0.3	-0.5	-0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	0.6	0.8	-0.4	0.9	-0.5	0.7	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	0.2	-0.2	-0.2	1.1	0.5	1.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.7	0.6	0.8	-0.8	0.1	-0.4	-0.4	-0.6
Age at first live birth	0.3	0.5	2.5	0.2	-0.0	-0.4	-1.6	-0.7	-0.0	-0.4
Alcohol intake frequency.	0.3	0.8	1.5	1.1	0.3	-0.5	1.2	-0.1	1.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	-0.1	0.4	0.0	-0.8	-1.1	-0.3	-0.8
Supplements: Vitamin C	0.3	0.3	0.8	0.7	0.1	-0.5	-0.6	0.9	0.7	-0.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.4	0.4	0.0	-0.1	-0.6	1.2	-0.1	-0.7
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.1	0.8	0.9	0.9	-0.5	0.5	-0.1
Leg fat percentage (left)	0.3	1.2	2.4	-1.5	-1.3	1.6	0.5	-0.9	-1.0	0.4
Average weekly beer plus cider intake	0.3	0.4	0.8	0.9	0.0	-0.8	-0.9	-0.4	0.5	0.6
Risk taking	0.3	0.4	1.4	-0.6	-0.1	-0.7	0.3	0.5	-0.4	-1.2
Unable to work because of sickness or disability	0.3	0.4	0.9	-0.8	-0.2	0.6	0.2	-0.6	-0.7	-1.0
Pack years of smoking	0.3	0.5	1.5	-1.2	-1.2	-0.0	0.5	-0.4	-0.1	-0.4
Depression (Nagel 2018)	0.2	0.4	1.1	0.1	-0.4	0.3	1.0	-0.8	0.1	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.7	3.4	-0.1	0.5	-0.4	-0.0	-0.7	-0.6	-1.8
Neuroticism (Nagel 2018)	0.2	0.5	1.7	1.3	0.5	-0.3	0.3	-0.1	1.2	0.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.9	-0.5	-0.3	-0.3	0.2	-0.5	-0.9	0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	-0.5	-0.7	0.3	0.1	1.0	-0.7	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.2	0.2	0.2	-1.0	-0.7	-0.4	-0.6	-1.1
Age at First Birth	0.2	0.3	0.8	-0.4	-0.9	0.2	-0.6	-0.3	-0.4	-0.9
LDL Cholesterol	0.2	0.3	1.0	0.6	0.3	-1.0	-0.3	0.5	-0.1	-0.5
Allergy or Eczema	0.2	0.4	1.6	0.4	0.5	-0.1	0.8	0.3	1.3	0.2
Supplements: Zinc	0.2	0.2	0.6	-0.8	-0.6	0.6	0.1	0.4	-0.3	0.1
Townsend deprivation index at recruitment	0.2	0.3	0.9	0.8	-0.1	-0.1	-0.3	0.0	0.4	1.0
Medication: Atenolol	0.2	0.2	0.5	0.7	0.4	-0.5	0.6	0.3	0.5	0.0
Medication: Levothyroxine sodium	0.2	0.3	1.2	0.2	0.1	0.9	1.1	0.3	-0.0	0.0
Allergy	0.2	0.5	1.3	-0.4	-0.1	1.2	0.8	1.0	-0.1	-0.1
Worrier / anxious feelings	0.2	0.4	1.3	-0.8	-1.1	-0.3	-0.6	0.4	-0.2	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.0	-0.2	0.3	1.0	-0.2	-1.0	-0.3	-0.6
Hair/balding pattern: Pattern 3	0.2	0.2	0.8	0.1	-0.4	-0.4	0.5	-0.3	0.9	0.6
Depression (self-reported)	0.2	0.2	0.9	-0.0	0.1	-1.0	-0.6	-0.4	-0.0	-0.1
Illnesses of mother	0.2	0.3	0.6	-0.6	0.2	-0.8	-0.6	-0.2	-0.7	-0.2
Pulse wave Arterial Stiffness index	0.2	0.2	1.1	0.4	0.2	-0.0	-1.1	0.5	0.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.2	0.5	-0.5	0.4	0.7	0.3	-0.9
High blood pressure (siblings)	0.2	0.3	0.6	0.2	-0.8	-0.3	0.7	-0.8	-0.2	-0.6
Exposure to tobacco smoke outside home	0.2	0.2	0.7	0.8	0.3	-0.6	-0.5	0.2	0.2	-0.4
Pulse wave peak to peak time	0.2	0.3	0.6	-0.8	-0.4	0.2	0.7	-0.5	-0.5	-0.1
Qualifications: College or University degree	0.2	0.5	1.5	-0.5	-0.6	-0.4	-0.6	1.2	-0.3	-0.9
Long-standing illness, disability or infirmity	0.2	0.3	1.4	0.3	0.2	-1.2	0.3	0.4	-0.1	-0.1
Osteoporosis (self-reported)	0.2	0.3	0.7	0.1	0.8	0.5	0.5	0.7	-0.1	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	-0.3	-0.6	-0.1	-0.5	0.4	-0.6	0.3
Ever depressed for a whole week	0.2	0.2	0.8	-0.0	-0.3	-0.2	-0.9	-0.5	-0.1	-0.5
Worry (Nagel 2018)	0.1	0.1	0.3	0.5	0.1	0.2	-0.5	-0.6	0.2	-0.3
Hair Pigment	0.1	1.7	4.7	-1.5	-1.0	-1.3	-0.3	0.5	-1.3	-2.2
Medication: Co-codamol	0.1	0.1	0.2	-0.2	-0.1	-0.4	0.0	-0.3	-0.4	0.4
Average weekly fortified wine intake	0.1	0.2	0.7	-0.2	-0.6	0.0	-0.1	0.8	0.1	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.6	-0.4	-0.5	0.0	-0.1	0.3	-0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.0	0.2	-0.7	-0.5	0.2	0.4	-0.5
Nervous feelings	0.1	0.2	1.0	0.2	0.0	-0.1	-1.0	-0.2	0.1	0.8
Neuroticism score	0.1	0.2	0.6	0.7	0.1	-0.1	-0.5	-0.1	0.7	0.1
Happiness	0.1	0.1	0.1	0.3	0.3	-0.2	0.2	-0.3	0.2	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.3	0.6	0.5	0.8	-0.0	-0.3	-0.7
Health satisfaction	0.1	0.1	0.5	-0.4	-0.0	0.2	-0.0	0.7	-0.5	0.0
Shortness of breath walking on level ground	0.1	0.1	0.5	-0.3	-0.7	-0.2	-0.4	0.3	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.7	0.3	0.3	-0.3	-0.1	-0.8	0.0	0.0
Miserableness	0.1	0.2	0.4	0.5	-0.4	-0.7	-0.1	-0.2	0.2	0.1
Guilty feelings	0.1	0.2	0.9	0.1	0.1	0.1	-0.9	-0.4	0.1	-0.7
High cholesterol (Self-reported)	0.1	0.2	0.3	0.5	0.1	-0.6	-0.6	0.4	0.2	0.3
Qualifications: None of the above	0.0	0.1	0.2	-0.1	-0.2	-0.2	0.3	0.1	-0.4	0.4

Hub : Genes

BCL2L11

Models

Trait associations