Hub : Genes

RP1-317E23.3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.063	0.0270	3.2e-03	0.011	NA	0.015	NA	0.011	4.5e-02	NA	2.5e-02	NA	4.7e-02
2	GTEx	Muscle Skeletal	0.120	0.0313	1.0e-10	0.134	NA	0.147	NA	0.150	4.6e-13	NA	2.9e-14	NA	1.6e-14
3	GTEx	Testis	0.177	0.0650	1.3e-04	0.019	NA	0.079	NA	0.064	4.6e-02	NA	2.2e-04	NA	8.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.9	2.4	-1.6	0.4	0.1
Bipolar Disorder or Schizophrenia	0.5	1.1	2.0	-1.4	-0.4	1.1
Depressed Affect (Nagel 2018)	0.3	0.5	0.7	-0.9	0.7	-0.6
Depression (Nagel 2018)	0.5	0.7	1.3	-1.1	-0.6	0.7
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.3	-0.2	-1.1	1.1
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.3	-0.0	-0.4
Schizophrenia (2018)	0.5	0.9	1.8	-0.5	-0.8	1.4
Schizophrenia vs Biploar Disorder	0.9	1.2	1.6	1.3	0.7	-1.2
Worry (Nagel 2018)	0.2	0.5	1.3	1.2	0.2	-0.3
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	1.0	0.8	0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.0	-0.4	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.5	0.7	0.3
Crohns Disease (2017)	0.3	0.7	1.5	0.6	1.2	-0.5
Irritable Bowel Disease (IBD)	0.6	1.4	2.1	0.3	1.4	-1.4
Ulcerative Colitis (UC)	0.6	1.1	2.4	-0.3	0.8	-1.5
Major Depression (MDD)	1.5	1.9	5.5	2.4	0.2	0.2
Reaction Time	0.3	0.5	1.2	1.1	0.4	-0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.3	1.5	-0.9	0.5
Breast Cancer	0.1	0.2	0.4	-0.7	-0.4	0.3
Ovarian Cancer	0.2	0.2	0.5	-0.4	0.7	-0.2
Prostate Cancer	0.3	0.5	0.7	0.2	0.8	-0.8
Age at First Birth	0.8	1.1	1.4	1.0	1.0	-1.2
Bipolar Disorder (2011)	0.5	0.5	1.1	-1.0	-0.1	0.6
Body Mass Index (BMI) (2010)	0.6	0.8	1.3	1.2	-0.1	-1.0
Coronary Artery Disease (CAD)	2.9	3.5	6.8	-2.6	-1.0	1.7
Crohns Disease (2012)	0.1	0.2	0.6	0.1	0.1	-0.8
Mean Putamen Volume	0.3	0.3	0.4	0.7	-0.6	0.3
Fasting Glucose	1.0	1.2	2.5	-1.0	-0.1	1.6
HbA1C	4.2	4.6	5.1	-1.9	-2.3	2.3
HDL Cholesterol	0.6	1.0	2.2	1.5	-0.8	0.5
LDL Cholesterol	1.2	1.9	5.3	-2.3	0.7	-0.2
Lupus	1.5	2.3	3.0	-1.5	1.3	-1.7
Neuroticism (2016)	0.7	1.0	1.8	0.3	-1.0	1.4
Primary Biliary Cirrhosis	0.9	1.2	3.2	-1.8	0.7	0.3
Rheumatoid Arthritis	0.9	1.2	2.0	0.4	1.2	-1.4
Schizophrenia (2014)	0.0	0.1	0.1	0.3	-0.3	0.4
Triglycerides	2.0	3.2	6.9	-2.6	1.5	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.8	-0.4	0.0
Ulcerative Colitis	1.4	2.1	3.6	-1.2	1.1	-1.9
Blood Eosinophil Count	1.4	11.1	16.7	-2.4	4.1	-3.3
Blood Platelet Count	0.4	4.2	11.5	0.9	-3.4	0.6
Blood Red Count	3.1	29.6	46.6	-4.1	-5.0	6.8
Blood White Count	0.0	0.2	0.4	0.6	0.3	0.1
Heel T-Score	0.7	5.4	8.2	1.7	-2.9	2.3
BMI	0.2	1.1	1.9	-0.9	-1.4	0.7
Height	1.6	30.7	44.1	5.6	-6.6	4.0
Waist Hip Ratio (WHR)	3.8	17.1	19.4	-4.4	-4.3	3.6
Systolic Blood Pressure	1.3	6.3	8.4	2.4	2.2	-2.9
Smoking Status	0.5	1.2	2.6	-1.6	1.0	0.0
Allergy or Eczema	1.0	2.6	3.8	0.8	1.9	-1.9
Cardiovascular Disease	0.4	1.2	2.5	0.3	1.1	-1.6
Hypothyroidism (self reported)	0.5	1.1	2.2	-1.1	-0.3	1.5
Respiratory disease	1.0	2.3	3.7	1.4	1.9	-1.0
Type 2 Diabetes (T2D) (2018)	1.6	3.0	8.9	-3.0	-0.2	0.4
Lung FEV1/FVC ratio	0.1	0.5	0.7	0.8	0.5	-0.8
Lung FVC	1.8	9.4	14.7	3.8	-3.1	2.0
Neuroticism	0.1	0.3	0.7	0.8	0.2	0.1
Chronotype (morning person)	0.4	1.0	1.9	1.0	0.2	-1.4
Hair Pigment	0.2	5.6	15.9	-4.0	0.8	0.6
Tanning	0.0	0.5	0.7	-0.2	-0.8	0.8
Hand grip strength (left)	1.0	2.6	3.8	1.4	-2.0	1.4
Number of treatments/medications taken	0.0	0.1	0.1	0.3	-0.0	0.3
Average weekly spirits intake	0.9	1.2	1.5	1.2	-0.9	1.1
Sensitivity / hurt feelings	0.7	1.3	2.2	-1.5	0.8	-1.0
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.9	-2.2	0.2	0.5
Hearing difficulty/problems: Yes	2.1	3.1	9.2	-3.0	-0.1	0.5
Relative age of first facial hair	1.2	2.5	3.9	0.8	1.7	-2.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.0	1.7	-0.1	0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.1	3.0	-1.7	0.3	0.3
Ever had hysterectomy (womb removed)	0.2	0.3	0.8	-0.9	-0.1	0.1
Systolic blood pressure, automated reading	1.5	4.3	6.9	2.6	1.4	-1.9
Eye problems/disorders: Diabetes related eye disease	2.9	3.1	7.8	-2.8	1.1	0.7
Angina	0.6	0.8	1.1	-1.0	0.9	-0.7
Medication for hormone replacement therapy	0.9	1.0	2.6	-1.6	-0.4	0.5
Vitamin and mineral supplements	3.9	5.3	14.2	-3.8	-0.1	1.3
Supplements: Zinc	2.3	2.5	5.4	-0.4	2.3	-1.4
Medication: Co-codamol	0.6	0.6	1.5	1.2	-0.2	0.6
Medication: Metformin	2.0	2.8	8.5	-2.9	0.1	0.2
Diabetes (father)	1.0	1.3	3.4	-1.8	0.4	0.5
Diabetes (mother)	1.4	1.8	3.5	-1.9	-0.7	1.2
Severe depression (siblings)	0.4	0.5	1.5	1.2	-0.1	0.0
Pack years adult smoking proportion	0.2	0.2	0.6	-0.8	0.3	0.0
Impedance of leg (right)	1.5	7.2	12.1	-3.5	-1.1	2.9
Leg fat-free mass (left)	0.7	3.9	8.4	2.9	-1.8	-0.3
Trunk fat percentage	1.8	7.0	7.9	-2.8	-2.7	2.5
Hand grip strength (right)	1.7	4.6	7.7	1.3	-2.8	2.1
Townsend deprivation index at recruitment	0.3	0.4	0.8	-0.9	0.4	-0.5
Current tobacco smoking	0.9	1.5	2.1	-1.5	-0.6	1.4
Average weekly fortified wine intake	0.5	0.6	0.8	0.9	-0.4	0.8
Maternal smoking around birth	3.0	4.4	5.7	-2.4	2.1	-1.7
Fed-up feelings	3.0	5.5	10.7	-3.3	2.1	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.4	-1.2	1.1	-0.6
Relative age voice broke	0.9	1.4	2.2	-0.2	1.5	-1.4
Taking other prescription medications	0.3	0.4	1.1	0.0	1.1	-0.4
Age when periods started (menarche)	0.2	0.5	1.5	1.2	-0.1	-0.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.9	-0.6	-0.6	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.6	0.6	-1.3	0.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.7	-0.8	0.8	0.5
Qualifications: CSEs or equivalent	0.9	1.3	2.3	0.7	1.0	-1.5
Serious illness, injury or assault to yourself	1.6	1.9	2.9	1.7	1.2	-1.2
High blood pressure	0.4	1.0	2.7	1.6	-0.3	-0.5
Hayfever, allergic rhinitis or eczema	1.0	2.2	3.8	0.2	1.9	-1.6
Multivitamins +/- minerals	2.8	3.6	9.8	3.1	-0.3	-1.0
Stomach or abdominal pain in last month	0.2	0.3	0.6	0.8	0.0	0.4
Supplements: Glucosamine	3.0	4.0	9.8	3.1	-1.4	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.4	0.6	0.6	0.3
Medication: Atenolol	0.4	0.5	1.5	-1.2	0.1	-0.2
Medication: Levothyroxine sodium	0.3	0.5	1.2	-0.5	-0.4	1.1
Sitting height	1.2	8.8	22.8	4.8	-1.6	1.0
Chronic bronchitis/emphysema (father)	0.3	0.3	0.5	-0.5	0.7	-0.4
High blood pressure (mother)	0.9	1.3	3.5	-0.2	0.6	-1.9
Body mass index (BMI)	0.1	0.4	1.0	-1.0	-0.2	-0.1
Impedance of leg (left)	1.1	5.3	10.0	-3.2	-0.6	2.3
Leg predicted mass (left)	0.7	4.0	8.8	3.0	-1.7	-0.4
Trunk fat mass	1.0	4.2	7.0	-1.3	-2.7	2.0
Waist circumference	1.0	3.7	5.6	-1.6	-2.4	1.7
Number of incorrect matches in round	0.7	1.2	2.8	1.7	-0.8	0.3
Past tobacco smoking	1.6	3.0	7.4	2.7	0.1	-1.3
Alcohol usually taken with meals	1.7	2.8	6.2	2.5	0.1	-1.5
Nervous feelings	0.3	0.6	1.4	1.2	0.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.8	-1.2	1.7	-0.8
Hearing difficulty/problems with background noise	1.3	2.1	3.2	-1.8	1.6	-0.6
Hair/balding pattern: Pattern 2	2.5	3.2	8.5	-0.7	2.9	-0.9
Had menopause	1.9	2.4	4.5	-1.4	2.1	-0.9
Had other major operations	0.5	0.6	1.2	-1.1	0.8	0.0
Forced vital capacity (FVC)	3.1	11.8	15.8	3.8	-4.0	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.9	1.1	-1.7	0.5
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.1	1.1	-1.5	1.2
Qualifications: None of the above	1.1	2.4	5.1	-2.3	-0.5	1.4
Financial difficulties in last 2 years	0.3	0.4	0.8	-0.9	-0.5	0.5
Mouth/teeth dental problems	2.0	3.1	7.0	2.7	1.1	-1.0
Heart attack	0.6	0.8	2.0	-1.4	0.3	-0.4
Allergy	1.9	4.3	7.2	-1.0	-2.7	2.2
Pain all over the body in last month	0.7	0.7	2.2	0.1	-1.5	-0.0
Diabetes (self-reported)	1.7	2.7	7.9	-2.8	0.2	-0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.6	-0.5	1.3	-1.2
Medication: Ramipril	0.5	0.6	1.3	0.0	0.8	-1.1
Medication: Simvastatin	0.5	0.7	1.1	-1.0	0.2	1.0
Fluid intelligence score	0.5	1.0	2.2	0.5	-1.5	0.7
Illnesses of siblings	0.9	1.2	3.6	-1.9	0.3	0.3
Neuroticism score	0.2	0.5	1.0	-0.4	1.0	-0.5
Weight	0.3	1.6	3.6	0.9	-1.9	0.7
Impedance of arm (right)	2.1	9.7	19.4	-4.4	-1.7	2.6
Arm fat percentage (right)	1.1	4.5	8.4	-2.9	-1.6	1.6
Trunk fat-free mass	1.5	8.4	22.9	4.8	-1.4	-0.6
Hip circumference	0.2	0.9	1.6	0.9	-1.3	0.5
Time employed in main current job	0.3	0.3	0.5	-0.3	-0.7	0.5
Alcohol intake versus 10 years previously	1.8	2.7	5.8	0.0	-1.5	2.4
Father’s age at death	0.7	1.0	1.9	1.4	-1.0	0.2
Worrier / anxious feelings	2.2	4.2	11.8	3.4	0.3	-0.9
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	7.8	-2.8	1.4	0.1
Falls in the last year	2.9	3.9	5.5	-1.4	-2.1	2.3
Hair/balding pattern: Pattern 3	1.5	2.2	3.3	0.4	-1.8	1.8
Number of live births	1.9	2.7	3.4	-1.9	-1.1	1.8
Forced expiratory volume in 1-second (FEV1)	2.9	9.9	13.9	3.5	-3.7	2.0
Pulse rate	1.9	3.2	9.1	-3.0	0.7	-0.3
Happiness	1.7	2.1	3.9	0.1	2.0	-1.6
Noisy workplace	0.5	0.6	1.2	-0.8	-0.1	1.1
Qualifications: A levels/AS levels or equivalent	1.4	3.1	7.0	2.6	0.2	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	-1.1	0.8	0.0
Mouth/teeth dental problems: Dentures	1.1	1.9	3.3	-0.9	-1.8	1.3
Asthma	3.5	7.0	10.8	1.6	3.3	-2.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.4	-0.8	-0.2
Medication: Cholesterol lowering	0.8	1.3	2.6	-1.6	0.2	1.1
Depression (self-reported)	0.3	0.4	1.0	-0.4	1.0	-0.2
Medication: Lansoprazole	0.4	0.4	1.2	-0.3	-0.1	1.1
Prospective memory result	1.0	1.2	2.6	0.9	0.5	-1.6
Lung cancer (father)	0.3	0.3	0.7	0.8	-0.6	0.0
Illnesses of mother	0.8	1.0	2.5	1.6	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	9.8	12.8	3.3	-3.6	2.4
Pulse wave Arterial Stiffness index	0.6	0.7	1.5	-1.2	0.6	0.6
Impedance of arm (left)	1.5	7.1	8.5	-2.9	-2.2	2.8
Arm fat mass (right)	0.4	1.5	2.4	-1.0	-1.6	1.1
Trunk predicted mass	1.5	8.5	23.4	4.8	-1.3	-0.7
Standing height	1.3	12.4	16.5	4.1	-4.1	2.1
Length of working week for main job	0.5	0.5	1.5	-0.1	-0.2	-1.2
Exposure to tobacco smoke at home	3.3	3.7	10.2	-3.2	0.9	0.4
Breastfed as a baby	0.3	0.4	0.7	0.8	-0.0	0.6
Tense / ‘highly strung’	1.0	1.7	3.4	-0.3	1.8	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	4.3	2.1	1.5	-1.7
Hair/balding pattern: Pattern 4	0.7	1.7	5.2	0.1	-2.3	0.1
Birth weight of first child	1.1	2.0	3.6	0.9	-1.9	1.3
Peak expiratory flow (PEF)	0.7	1.7	3.3	1.8	-1.2	0.5
Pulse wave reflection index	0.2	0.2	0.3	-0.6	0.3	0.4
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.5	-1.9	-0.0	0.6
Loud music exposure frequency	1.9	2.0	4.5	-2.1	-0.9	0.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	2.6	0.9	0.3	-1.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-0.9	0.3	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.4	0.5	0.1
Medication: Paracetamol	0.2	0.4	1.0	-0.1	-0.1	1.0
Headache pain in last month	0.5	0.8	2.0	0.1	-0.7	1.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.2	1.3	0.6	-1.5
Glaucoma (self-reported)	1.3	1.6	2.4	-1.5	1.1	-1.0
Gout (self-reported)	1.7	2.4	3.8	-1.3	-1.3	2.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.2	-0.9	0.3	1.1
Medication: Amlodipine	0.1	0.2	0.4	0.1	0.5	0.6
Medication: Ventolin 100micrograms inhaler	1.7	2.2	3.7	1.1	1.9	-1.3
Birth weight	1.4	3.0	6.2	2.5	-1.4	0.9
Chronic bronchitis/emphysema (mother)	3.4	4.0	11.7	-3.4	-0.2	0.4
High blood pressure (siblings)	0.8	1.1	2.4	1.5	-1.0	0.2
Forced vital capacity (FVC), Best measure	3.1	11.4	14.5	3.8	-3.6	2.5
Body fat percentage	1.5	6.1	7.9	-2.8	-2.3	2.3
Leg fat percentage (right)	1.3	4.6	9.2	-3.0	-1.2	1.8
Arm fat-free mass (right)	1.5	7.7	20.7	4.5	-1.4	-0.7
Exposure to tobacco smoke outside home	0.5	0.7	1.6	-1.3	0.7	-0.1
Comparative body size at age 10	0.3	0.9	1.8	0.9	-1.4	-0.0
Number of full brothers	1.7	2.1	4.3	-2.1	1.2	-0.7
Worry too long after embarrassment	0.6	0.9	1.9	1.4	0.1	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	-0.6	0.9	-0.5
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.3	0.1	0.1
Number of children fathered	2.2	2.5	3.5	-1.3	-1.5	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	1.3	-0.0	0.1
Age at first live birth	1.0	1.7	4.2	2.1	0.6	-0.7
Pulse wave peak to peak time	0.9	1.1	2.4	1.6	-0.9	-0.4
Health satisfaction	0.6	0.8	1.6	0.0	-0.8	1.3
Shortness of breath walking on level ground	2.0	2.3	3.3	1.1	1.6	-1.8
Qualifications: College or University degree	1.2	3.8	11.2	3.3	-0.5	-0.2
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.9	0.0	-0.4
Mouth/teeth dental problems: Loose teeth	1.4	1.6	2.8	-1.2	-0.8	1.7
Emphysema/chronic bronchitis	0.9	1.0	2.3	-0.9	1.5	0.2
Medication for pain relief, constipation, heartburn	0.4	0.6	1.1	1.0	0.3	-0.9
Neck or shoulder pain in last month	3.7	5.2	7.3	-1.8	-2.2	2.7
Medication: Blood pressure	0.1	0.2	0.4	-0.2	-0.5	0.7
Angina (self-reported)	0.4	0.5	1.0	-1.0	0.6	-0.4
Migraine (self-reported)	0.2	0.2	0.6	-0.8	0.1	-0.3
Medication: Ibuprofen	0.0	0.0	0.0	0.1	-0.1	0.0
Medication: Allopurinol	0.5	0.7	1.5	-1.2	0.2	0.7
Medication: Omeprazole	0.7	0.8	2.3	-1.5	-0.3	0.3
Medication: Seretide 50 evohaler	0.6	0.7	1.4	1.2	0.6	-0.5
Mean time to correctly identify matches	0.1	0.2	0.5	0.7	0.1	0.4
Heart disease (mother)	2.0	2.4	3.2	-1.6	-1.2	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	-0.3	0.2	-0.1
Whole body fat mass	0.8	3.4	5.2	-1.4	-2.3	1.8
Leg fat mass (right)	0.5	2.1	3.0	-1.7	-1.3	1.2
Arm predicted mass (right)	1.5	7.5	20.4	4.5	-1.2	-0.7
Pulse rate, automated reading	2.0	6.6	19.2	-4.4	0.1	0.7
Alcohol intake frequency.	0.9	2.2	3.7	1.5	-1.9	0.7
Comparative height size at age 10	2.5	14.0	20.8	4.2	-4.6	1.8
Number of full sisters	0.3	0.4	0.6	-0.8	0.7	-0.1
Suffer from ‘nerves’	1.1	1.8	4.0	-2.0	1.1	-0.0
Overall health rating	0.3	0.7	1.9	-0.2	1.4	0.4
Chest pain or discomfort	1.6	2.3	6.4	-2.5	0.7	-0.3
Had major operations	0.2	0.2	0.5	0.4	-0.2	0.7
Age at last live birth	0.1	0.2	0.5	0.0	-0.3	0.7
Family relationship satisfaction	0.6	0.7	2.1	-0.3	1.5	-0.0
Leg pain on walking	0.5	0.6	1.8	-1.3	-0.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.3	0.7	0.9	-1.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.4	-0.7	1.2	-0.1
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	3.2	-1.8	-1.2	1.1
Medication: Aspirin	0.2	0.3	0.8	-0.9	0.2	0.3
Supplements: Vitamin C	4.1	4.8	10.6	3.3	0.9	-1.8
Knee pain experienced in last month	1.6	2.4	3.8	-0.8	-2.0	1.7
Hypertension (Self-reported)	0.4	1.1	2.6	1.6	-0.3	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.1	-0.7	0.0
Illnesses of father: Heart disease	0.5	0.7	1.2	-0.0	0.9	1.1
Illnesses of siblings: Diabetes	0.5	0.6	0.9	-0.3	-0.8	0.9
Smoking status: Previous	1.8	2.6	6.2	-2.5	-0.5	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.4	0.1	-0.6	-0.1
Whole body fat-free mass	1.2	6.7	17.6	4.2	-1.5	-0.6
Leg fat-free mass (right)	0.8	4.5	11.0	3.3	-1.4	-0.8
Arm fat percentage (left)	1.0	4.0	5.9	-2.4	-1.8	1.6
Average weekly red wine intake	0.1	0.1	0.1	0.2	0.4	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	-0.6	0.3	0.6
Mood swings	1.2	2.1	3.1	-1.2	1.3	-1.8
Loneliness, isolation	0.3	0.3	0.9	-0.3	0.9	-0.3
Long-standing illness, disability or infirmity	0.9	1.4	2.2	-1.3	1.5	-0.5
Ever had bowel cancer screening	1.0	1.1	1.6	1.0	0.9	-1.3
Diabetes diagnosed by doctor	1.9	3.1	9.4	-3.1	-0.0	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	-1.0	-0.1	0.3
Friendships satisfaction	0.6	0.8	1.5	0.4	1.2	-0.8
Qualifications: nursing, teaching	1.2	1.8	4.5	2.1	-0.9	0.4
Commuting to job workplace: Walk	1.5	1.6	2.5	1.6	-1.2	1.0
Eye problems/disorders: Cataract	1.8	2.0	3.6	-0.8	-1.4	1.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.5	-1.2	-0.7	1.2
Medication for cholesterol	0.4	0.6	1.7	-0.1	-0.2	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.2	-1.8	0.2	0.9
Back pain experienced in last month	0.4	0.6	1.3	-1.2	0.1	0.8
Mineral and other dietary supplements	3.2	4.3	12.4	-3.5	0.5	-0.4
Breast cancer (self-reported)	0.3	0.3	0.5	0.7	-0.1	0.7
Asthma (self-reported)	4.2	8.3	11.9	2.1	3.4	-2.9
Osteoporosis (self-reported)	0.7	0.9	1.7	0.5	1.3	-0.8
Osteoarthritis (self-reported)	1.9	2.5	4.1	0.0	-2.0	1.8
Medication: Aspirin	0.2	0.2	0.5	-0.7	0.0	0.3
Medication: Gliclazide	1.0	1.1	3.3	-1.8	-0.2	0.3
Illnesses of father: None of the above (group 1)	0.8	1.0	1.6	1.3	-0.4	-1.1
Smoking status: Current	0.5	0.8	1.3	-1.1	-0.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	8.2	2.9	-1.7	0.4
Whole body water mass	1.2	6.6	17.5	4.2	-1.4	-0.6
Leg predicted mass (right)	0.8	4.4	10.7	3.3	-1.4	-0.8
Arm fat mass (left)	0.5	2.0	3.6	-0.8	-1.9	1.3
Number of self-reported non-cancer illnesses	0.2	0.3	0.8	-0.1	0.9	-0.1
Average weekly champagne plus white wine intake	0.6	0.8	1.8	0.7	-1.4	0.5
Miserableness	0.7	1.1	1.3	-0.9	1.1	-1.1
Guilty feelings	0.4	0.7	1.0	-1.0	-0.3	0.9
Wears glasses or contact lenses	0.4	0.5	1.0	0.7	1.0	0.1
Ever taken oral contraceptive pill	3.0	3.4	4.7	-0.9	-2.1	2.2
Hearing aid user	0.8	0.9	1.4	-0.8	0.8	-1.2
Mother’s age at death	2.5	3.1	5.9	2.4	-1.6	0.8
Financial situation satisfaction	0.6	0.7	1.3	-0.8	1.1	-0.4
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	0.9	0.5	-0.7
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.3	-0.1	-0.4
Eye problems/disorders: Glaucoma	1.4	1.7	2.5	-1.6	1.3	-1.0
Medication: Blood pressure	0.7	1.4	3.4	1.8	-0.7	-0.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.4	0.2	-1.2	1.1
Supplements: Fish oil (including cod liver oil)	2.6	3.4	10.2	3.2	0.0	-0.1
High cholesterol (Self-reported)	2.2	3.9	11.2	-3.3	0.2	0.6
Medication: Bendroflumethiazide	0.0	0.0	0.0	0.2	0.1	-0.1
Medication: Paracetamol	0.3	0.4	1.3	0.1	0.1	1.1
Medication: Lisinopril	0.7	0.9	1.7	-0.4	0.9	-1.3
Medication: Atorvastatin	1.3	1.6	4.8	-2.2	0.3	-0.3
Illnesses of father: High blood pressure	0.4	0.5	0.9	-0.7	1.0	0.2
Alcohol drinker status: Never	0.1	0.2	0.2	-0.4	-0.4	0.4
Ever smoked	0.7	1.2	1.9	-1.4	-0.5	1.2
Basal metabolic rate	0.9	5.1	12.5	3.5	-1.6	-0.3
Leg fat percentage (left)	1.0	3.5	8.2	-2.9	-0.7	1.3
Arm fat-free mass (left)	1.1	5.8	15.7	4.0	-1.2	-0.5
Number of operations (self-reported)	0.3	0.4	1.1	0.1	-0.3	1.1
Average weekly beer plus cider intake	2.4	3.4	8.1	-2.9	0.3	1.4
Irritability	1.7	2.9	7.6	-2.8	0.0	1.0
Risk taking	0.2	0.3	0.8	-0.9	-0.1	-0.2
Ever had prostate specific antigen (PSA) test	4.6	5.3	6.8	2.4	-2.6	1.8
Fractured/broken bones in last 5 years	1.5	1.9	4.9	-2.2	0.9	-0.4
Age started oral contraceptive pill	0.7	0.9	1.7	0.6	1.3	-0.9
Diastolic blood pressure, automated reading	0.1	0.4	0.8	-0.4	0.5	-0.9
Ever depressed for a whole week	0.3	0.3	0.6	0.1	-0.7	0.7
Unable to work because of sickness or disability	2.4	3.1	4.3	-1.5	-1.7	2.1
Commuting to job workplace: Cycle	1.7	2.1	3.4	0.5	1.6	-1.9
Myopia	0.2	0.2	0.4	0.5	0.7	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.0	-1.0	0.2	0.3
Cholesterol lowering medication	2.1	3.1	4.7	-2.2	1.5	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.4	-1.2	-0.2	0.4
Pain experienced in last month	1.8	3.0	4.6	0.5	2.1	-2.1
Supplements: Calcium	0.4	0.5	0.8	-0.9	0.1	-0.8
Basal cell carcinoma (self-reported)	1.4	1.7	2.0	-1.4	1.4	-1.1
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.3	-1.5	0.6	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	0.5	0.6	-0.1
Heart disease (siblings)	0.9	1.2	1.7	0.9	1.3	-1.0
Alcohol drinker status: Previous	0.9	1.1	1.7	-1.3	-0.8	0.9
Pack years of smoking	0.2	0.3	0.8	-0.9	0.4	-0.0
Impedance of whole body	1.5	7.6	12.5	-3.5	-1.6	2.8
Leg fat mass (left)	0.4	1.6	2.6	-1.6	-1.1	1.0
Arm predicted mass (left)	0.8	4.2	11.5	3.4	-0.9	-0.4