Hub : Genes

RABGAP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0940	0.0270	6.5e-09	0.068	0.071	0.082	0.062	0.075	1.1e-08	5.9e-09	3.8e-10	4.9e-08	1.7e-09
2	GTEx	Esophagus Mucosa	0.1690	0.0630	4.0e-04	0.066	NA	0.070	NA	0.076	3.3e-05	NA	2.0e-05	NA	8.4e-06
3	GTEx	Esophagus Muscularis	0.0960	0.0420	1.6e-03	0.011	NA	0.025	NA	0.034	7.0e-02	NA	1.2e-02	NA	3.7e-03
4	GTEx	Skin Sun Exposed Lower leg	0.0530	0.0270	4.5e-03	0.013	NA	0.017	NA	0.024	2.7e-02	NA	1.4e-02	NA	4.1e-03
5	GTEx	Testis	0.1300	0.0610	2.0e-03	0.037	NA	0.029	NA	0.010	9.4e-03	NA	1.9e-02	NA	1.1e-01
6	METSIM	Adipose	0.0428	0.0156	7.7e-06	0.029	0.031	0.045	0.033	0.055	2.6e-05	1.6e-05	2.3e-07	9.8e-06	1.2e-08
7	NTR	Blood	0.0259	0.0092	5.3e-06	0.008	0.016	0.013	0.016	0.013	1.2e-03	4.3e-06	3.4e-05	5.8e-06	3.6e-05
8	TCGA	Esophageal Carcinoma	0.1980	0.1040	9.5e-03	0.070	0.039	0.067	NA	0.078	3.1e-03	2.2e-02	3.6e-03	NA	1.8e-03
9	TCGA	Glioblastoma Multiforme	0.1700	0.0830	7.5e-06	0.167	0.172	0.157	NA	0.209	8.9e-06	6.5e-06	1.7e-05	NA	5.6e-07
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0192	0.0134	4.5e-03	0.008	0.015	0.009	NA	0.008	3.8e-02	7.4e-03	2.8e-02	NA	3.4e-02
11	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0430	0.0310	7.0e-03	0.036	0.037	0.032	NA	0.038	4.0e-03	3.5e-03	5.7e-03	NA	2.9e-03
12	TCGA	Lung Squamous Cell Carcinoma	0.0512	0.0430	8.4e-03	-0.001	0.009	0.012	NA	0.007	3.8e-01	3.1e-02	1.3e-02	NA	4.2e-02
13	TCGA	Testicular Germ Cell Tumors	0.1220	0.0620	3.5e-05	0.047	0.058	0.000	NA	0.031	8.9e-03	4.2e-03	3.2e-01	NA	2.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.1	0.2	0.7	0.2	0.7	-0.3	0.1	0.8	0.6	0.4	-0.6	0.3	0.2	0.5	-0.3	0.2
Bipolar Disorder or Schizophrenia	0.1	0.1	0.8	0.4	0.8	0.2	-0.0	0.3	0.9	-0.0	-0.2	-0.2	0.0	0.2	0.1	-0.1
Depressed Affect (Nagel 2018)	5.4	11.4	15.2	3.4	-3.3	3.2	-3.3	-3.4	3.2	-3.7	-2.7	-3.5	-3.8	-3.9	-2.4	-3.7
Depression (Nagel 2018)	0.7	1.1	2.5	1.1	-0.7	0.9	-0.9	-0.9	1.1	-1.0	-1.6	-0.8	-0.8	-1.1	-1.3	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.4	-1.2	1.3	-0.8	1.1	1.2	-0.8	0.9	0.1	1.5	1.4	0.7	0.4	1.4
Neuroticism (Nagel 2018)	2.6	6.1	9.5	3.0	-2.2	2.8	-1.7	-2.9	2.6	-3.1	-1.0	-2.6	-2.8	-2.6	-0.4	-2.9
Schizophrenia (2018)	0.1	0.1	0.5	0.3	0.5	0.5	-0.1	-0.0	0.7	-0.3	0.3	-0.5	-0.1	-0.1	0.4	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	3.2	1.0	-0.5	1.8	0.4	-0.5	0.6	-1.1	-0.9	-1.4	-0.3	-1.0	0.4	-0.7
Worry (Nagel 2018)	0.6	1.3	6.8	0.1	0.9	0.5	2.0	0.2	-0.2	0.0	1.3	0.6	0.9	0.9	2.6	0.7
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	-1.0	1.2	-0.6	1.1	-0.2	-0.1	0.4	1.3	0.8	0.6	1.0	0.9	0.6
Alzheimer’s Disease (in father)	0.6	0.6	1.6	-0.4	-1.2	-1.1	-1.3	-0.8	-1.2	0.8	-0.0	0.0	-0.4	0.2	-0.7	-0.2
Alzheimer’s Disease (including proxy)	0.3	0.5	1.3	-1.1	0.2	-1.0	0.3	-0.7	-0.7	0.6	1.1	0.7	0.2	0.9	0.3	0.3
Crohns Disease (2017)	0.2	0.5	1.0	-0.3	0.7	-1.0	0.5	1.0	-0.8	0.7	0.0	0.6	0.8	0.6	0.4	0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.8	-0.1	0.6	-0.8	-0.8	0.6	-0.0	0.4	-0.4	-0.0	0.0	-0.2	-0.9	-0.0
Ulcerative Colitis (UC)	0.7	1.2	4.1	0.5	-0.2	0.2	-2.0	-0.4	1.0	-0.5	-0.9	-1.0	-1.2	-1.3	-2.0	-1.1
Major Depression (MDD)	0.6	0.7	2.3	0.9	-0.7	1.1	0.8	-1.5	0.3	-0.8	0.6	-0.8	-0.4	-0.1	1.0	-0.6
Reaction Time	0.1	0.2	0.4	-0.5	-0.1	-0.4	0.3	0.3	-0.3	0.4	-0.0	0.6	0.4	0.6	0.3	0.6
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.6	-1.9	0.4	-1.3	0.7	1.4	-1.0	1.0	0.7	1.9	1.3	1.2	0.7	1.5
Breast Cancer	0.3	0.7	2.4	-0.1	-1.3	0.0	-0.8	-0.6	-0.9	0.6	-1.3	-0.7	-0.5	-0.3	-1.5	-0.3
Ovarian Cancer	0.2	0.2	0.9	-0.0	-0.2	-0.5	-0.4	-0.9	-1.0	0.6	0.7	0.0	-0.1	0.3	0.1	-0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.5	1.6	0.6	-0.1	1.1	-0.3	-0.3	1.2	-0.9	-0.5	-0.7	-0.7	-0.9	-0.5	-0.8
Bipolar Disorder (2011)	0.4	0.4	1.1	0.5	1.0	-0.2	-0.8	0.5	0.9	-0.1	-0.7	0.1	-0.3	-0.9	-0.9	-0.3
Body Mass Index (BMI) (2010)	1.5	2.1	6.2	1.5	-1.5	1.7	-0.8	-1.3	1.3	-2.5	-1.3	-1.5	-1.3	-1.6	-0.3	-1.4
Coronary Artery Disease (CAD)	0.8	1.0	3.1	0.3	1.4	0.4	1.8	1.1	-0.1	0.2	0.7	0.3	1.6	0.6	1.3	1.2
Crohns Disease (2012)	0.1	0.1	0.6	0.2	0.4	-0.3	0.1	0.5	-0.1	0.1	0.5	0.3	0.2	0.3	0.8	0.2
Mean Putamen Volume	0.2	0.2	1.8	0.2	-1.3	0.4	0.0	-0.4	0.1	-0.1	-0.1	-0.0	-0.4	-0.1	-0.0	-0.4
Fasting Glucose	0.8	1.0	3.6	1.0	-0.7	1.0	-0.4	-1.9	1.1	-1.4	-0.2	-0.7	-1.0	-0.5	0.1	-1.1
HbA1C	1.6	1.8	3.4	1.0	-1.2	1.0	-1.3	-1.8	0.9	-1.8	-1.8	-1.0	-1.2	-1.5	-1.2	-1.2
HDL Cholesterol	0.2	0.4	0.9	-1.0	0.4	-0.9	0.4	0.6	0.1	0.9	-0.4	0.7	0.6	0.2	-0.7	0.8
LDL Cholesterol	0.8	1.2	1.9	1.4	-0.9	1.2	-0.8	-1.2	1.0	-1.1	-1.0	-1.3	-1.0	-1.2	-1.2	-1.1
Lupus	1.0	1.5	3.0	-1.7	-0.0	-1.6	0.5	1.2	-1.1	1.3	1.1	1.6	1.0	1.6	-0.1	1.4
Neuroticism (2016)	1.2	1.7	5.3	1.1	-1.7	1.2	-0.5	-2.3	1.0	-2.1	0.6	-0.6	-1.4	-0.7	1.0	-1.4
Primary Biliary Cirrhosis	1.5	2.1	3.8	2.0	-0.6	1.6	-1.3	-0.5	1.8	-1.9	-1.0	-1.6	-1.5	-1.5	-1.1	-1.6
Rheumatoid Arthritis	1.0	1.4	2.7	-1.2	1.0	-0.7	1.7	1.6	-0.5	0.6	-0.7	1.6	1.4	1.2	0.6	1.4
Schizophrenia (2014)	0.6	1.3	2.3	1.2	-1.0	1.5	-1.1	-0.7	1.5	-0.8	-1.1	-1.2	-1.2	-1.3	-0.6	-1.3
Triglycerides	1.5	2.5	5.5	1.9	0.3	2.2	-0.7	-1.1	2.1	-2.3	-1.2	-1.9	-1.4	-1.5	-0.5	-1.8
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.5	1.3	-0.2	1.2	-0.4	-1.4	1.2	-1.6	-0.6	-1.2	-1.0	-1.1	-0.2	-1.3
Ulcerative Colitis	0.3	0.4	1.4	-0.5	1.0	-0.9	-0.8	0.6	0.0	1.0	0.2	0.1	0.2	-0.0	-1.2	0.3
Blood Eosinophil Count	0.7	5.3	10.4	-2.5	1.0	-2.0	2.3	1.1	-3.2	2.5	2.4	2.0	2.5	2.4	2.5	2.5
Blood Platelet Count	0.5	5.9	14.5	1.3	-2.3	1.6	-2.9	-2.9	0.9	-1.4	-3.3	-2.2	-2.3	-2.8	-3.8	-2.1
Blood Red Count	0.9	8.7	20.0	-2.3	3.5	-1.6	4.5	2.6	-2.4	1.5	1.5	3.2	3.6	3.1	3.4	3.1
Blood White Count	1.0	7.4	11.1	2.0	-1.6	2.7	-2.1	-3.3	2.7	-3.3	-3.2	-3.0	-2.7	-3.0	-2.2	-3.0
Heel T-Score	1.5	11.8	19.8	3.1	-2.9	2.8	-4.0	-3.5	3.3	-3.4	-1.7	-3.6	-4.5	-3.9	-2.5	-4.4
BMI	0.6	3.4	12.6	0.8	-2.6	1.4	-0.9	-2.9	1.4	-3.5	-1.4	-1.0	-1.9	-1.1	-0.6	-1.7
Height	2.6	50.5	71.1	-7.0	4.8	-5.3	8.3	7.9	-5.4	4.6	6.8	8.3	7.9	8.4	7.6	8.2
Waist Hip Ratio (WHR)	0.1	0.6	2.2	-0.7	-1.4	-0.6	-0.6	-1.5	-1.0	0.5	-0.1	0.2	-0.2	0.2	-0.6	0.1
Systolic Blood Pressure	4.3	21.5	33.3	5.0	-2.9	5.5	-3.1	-4.1	5.2	-5.5	-2.6	-5.5	-5.4	-5.2	-2.0	-5.8
Smoking Status	0.2	0.4	0.9	1.0	-0.2	0.6	0.2	-0.9	-0.1	-0.7	0.8	-0.8	-0.3	-0.0	0.9	-0.6
Allergy or Eczema	0.2	0.5	2.5	-0.2	1.6	0.4	1.1	-0.4	-0.1	0.2	0.7	-0.3	0.3	0.1	1.3	-0.2
Cardiovascular Disease	2.7	9.0	14.9	2.9	-3.3	3.3	-2.2	-3.5	2.7	-3.9	-1.1	-3.0	-3.7	-3.0	-0.7	-3.7
Hypothyroidism (self reported)	0.5	1.3	4.0	-0.2	1.0	0.2	1.7	1.0	-0.3	0.1	1.5	0.9	1.2	1.1	2.0	1.1
Respiratory disease	0.1	0.2	0.6	-0.1	0.6	-0.1	0.7	0.4	-0.3	0.1	-0.4	0.4	0.6	0.2	0.1	0.5
Type 2 Diabetes (T2D) (2018)	5.4	10.1	17.6	2.3	-4.2	2.4	-3.4	-4.2	1.8	-2.8	-1.4	-3.6	-4.1	-3.3	-2.5	-3.8
Lung FEV1/FVC ratio	1.2	6.0	10.7	2.9	-1.8	2.9	-1.0	-2.4	2.6	-3.3	0.3	-2.9	-2.9	-2.3	1.0	-3.2
Lung FVC	0.5	2.7	6.0	-0.8	2.2	-0.4	2.5	1.6	-0.8	2.2	1.1	1.1	2.0	1.4	2.2	1.5
Neuroticism	1.1	2.6	6.7	2.0	-0.3	2.3	0.1	-1.5	1.9	-2.6	0.3	-1.6	-1.4	-1.4	1.3	-1.7
Chronotype (morning person)	0.9	2.1	7.3	1.0	-1.6	0.5	-2.0	0.5	0.8	0.3	-2.2	-1.2	-1.3	-1.6	-2.7	-1.0
Hair Pigment	0.3	9.3	20.8	2.4	-4.6	2.7	-2.9	-3.6	2.0	-3.3	-2.9	-2.8	-3.1	-3.1	-2.7	-2.9
Tanning	0.5	6.3	18.3	-0.5	4.3	-0.4	3.7	3.2	-0.3	1.7	1.9	2.0	3.0	2.1	2.9	2.6
Hand grip strength (left)	0.5	1.3	4.2	0.6	2.1	0.8	1.6	1.6	1.1	-0.5	0.8	0.2	1.2	0.5	1.5	0.8
Number of treatments/medications taken	1.3	2.4	6.6	1.6	-0.3	2.5	0.9	-1.5	2.0	-2.6	-0.5	-1.1	-1.1	-1.1	1.6	-1.5
Average weekly spirits intake	0.5	0.6	3.7	0.2	-1.9	0.0	-1.1	-1.0	-0.5	-0.1	0.8	-0.5	-0.6	-0.1	-0.7	-0.2
Sensitivity / hurt feelings	0.4	0.6	1.3	0.4	-1.1	0.9	-0.7	-0.2	1.0	-1.1	-0.7	-0.5	-1.0	-0.6	-0.5	-0.9
Frequency of depressed mood in last 2 weeks	1.8	2.5	3.6	1.5	-1.1	1.2	-1.9	-1.4	1.5	-1.5	-1.8	-1.4	-1.7	-1.8	-1.9	-1.6
Hearing difficulty/problems: Yes	0.4	0.6	1.2	0.9	-1.1	0.9	-0.1	-1.1	-0.1	-1.1	0.5	-1.0	-0.7	-0.5	0.8	-0.7
Relative age of first facial hair	0.7	1.4	3.1	-1.2	1.5	-1.6	0.4	1.1	-1.3	1.8	-0.2	1.2	1.2	0.8	-0.6	1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.4	-0.6	-0.7	-0.9	0.1	0.6	-0.8	1.0	1.5	0.7	-0.2	0.9	0.6	0.0
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	0.3	0.7	-0.2	-0.3	0.3	0.4	-0.0	0.6	-0.0	-0.2	-0.2	0.0	-0.3
Ever had hysterectomy (womb removed)	1.3	1.4	3.3	1.8	-0.8	1.7	-0.9	-0.8	0.9	-0.7	0.2	-1.7	-1.2	-1.6	0.1	-1.5
Systolic blood pressure, automated reading	2.4	7.0	13.2	2.1	-2.5	2.3	-2.6	-3.1	2.4	-3.1	-1.2	-2.6	-3.6	-2.6	-1.7	-3.5
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.4	0.5	-1.6	-0.1	-1.3	-1.3	-0.4	-0.3	-0.2	-1.0	-1.2	-0.8	-1.3	-1.0
Angina	1.4	1.9	3.8	1.4	-0.7	1.5	-0.3	-2.0	1.9	-1.9	0.5	-0.9	-1.6	-0.9	1.1	-1.7
Medication for hormone replacement therapy	0.5	0.6	1.6	0.4	-0.6	0.5	-0.8	-0.8	1.2	-0.8	-0.1	-0.5	-1.2	-0.6	-0.2	-1.3
Vitamin and mineral supplements	1.1	1.5	2.6	-1.1	1.3	-0.8	1.4	1.0	-0.7	0.8	1.1	1.3	1.6	1.6	1.5	1.5
Supplements: Zinc	0.4	0.5	2.3	0.3	0.9	0.2	-0.5	0.1	0.6	0.4	-1.3	-0.1	0.1	-0.6	-1.5	0.1
Medication: Co-codamol	0.9	1.0	2.9	1.2	1.1	1.7	1.1	-0.4	1.6	-0.9	-0.1	-0.8	0.0	-0.5	1.3	-0.5
Medication: Metformin	6.2	8.7	16.6	2.5	-4.0	2.2	-3.3	-3.5	1.4	-2.3	-0.9	-3.4	-4.1	-2.9	-2.1	-3.7
Diabetes (father)	0.6	0.7	1.4	0.1	-0.8	0.7	-0.7	-0.8	1.0	-1.0	-1.0	-0.8	-1.2	-0.8	-0.3	-1.2
Diabetes (mother)	2.2	2.8	5.9	1.7	-1.6	0.9	-2.4	-2.1	1.0	-1.4	-0.6	-1.9	-1.9	-1.9	-1.5	-1.9
Severe depression (siblings)	5.1	5.7	10.4	1.7	-2.3	1.2	-2.8	-3.2	1.7	-1.6	-2.3	-2.4	-2.8	-2.6	-3.1	-2.5
Pack years adult smoking proportion	0.3	0.4	1.2	0.5	1.1	0.8	0.9	0.0	0.7	-0.9	-0.8	-0.1	0.5	-0.4	0.4	0.2
Impedance of leg (right)	1.2	5.6	11.8	-2.8	1.3	-2.5	1.4	2.6	-3.0	3.4	-0.0	2.2	2.9	2.3	-0.2	3.1
Leg fat-free mass (left)	0.2	0.9	5.4	0.2	-0.4	0.8	0.9	-0.6	0.9	-2.3	0.6	0.4	-0.4	0.3	1.4	-0.3
Trunk fat percentage	1.3	5.3	8.7	1.1	-2.9	1.4	-2.2	-2.7	1.3	-3.0	-2.7	-1.6	-2.9	-2.0	-2.5	-2.6
Hand grip strength (right)	0.4	1.0	3.7	0.1	1.2	0.7	1.5	1.3	0.5	-0.6	1.1	0.4	0.9	0.6	1.9	0.7
Townsend deprivation index at recruitment	2.1	2.9	5.7	1.7	-1.1	1.5	-1.6	-2.4	1.2	-1.7	-0.3	-2.3	-2.1	-1.8	-1.3	-2.2
Current tobacco smoking	0.5	0.9	2.1	-0.7	1.1	-0.9	0.9	0.7	-0.9	1.4	1.0	0.8	0.8	1.2	0.6	0.7
Average weekly fortified wine intake	0.4	0.5	1.4	-0.1	1.0	0.2	1.1	1.2	-0.3	0.3	0.8	0.2	0.5	0.5	0.9	0.4
Maternal smoking around birth	0.2	0.3	1.0	0.9	0.0	0.1	-1.0	-0.1	0.3	0.6	-0.3	-0.3	-0.7	-0.7	-0.4	-0.5
Fed-up feelings	6.6	11.9	15.6	3.0	-3.2	3.2	-3.5	-3.8	3.3	-3.5	-3.1	-3.5	-3.9	-4.0	-2.7	-3.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.4	6.3	2.1	-0.9	2.5	-1.0	-1.2	2.0	-2.0	-1.9	-2.2	-1.7	-2.2	-1.2	-2.0
Relative age voice broke	0.2	0.3	1.7	-0.3	0.5	-0.4	0.3	0.6	-0.6	1.3	0.0	0.3	0.4	0.3	-0.4	0.4
Taking other prescription medications	1.7	2.6	5.9	2.0	-0.6	2.4	-0.2	-1.6	1.9	-1.9	-1.5	-1.9	-1.3	-1.9	-0.1	-1.6
Age when periods started (menarche)	0.5	1.3	2.7	1.4	1.0	1.6	0.3	-0.1	1.3	-1.5	-1.4	-1.3	-0.2	-1.5	-0.4	-0.7
Bilateral oophorectomy (both ovaries removed)	3.4	4.0	6.2	2.1	-2.2	1.9	-2.2	-1.9	1.4	-1.5	-1.2	-2.5	-2.4	-2.4	-0.8	-2.5
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.6	0.6	0.1	-0.2	-0.4	0.8	0.1	-0.3	0.2	-0.1	-0.3	-0.0	-0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.9	1.4	0.1	1.3	0.1	-0.5	1.3	-1.0	0.0	-1.1	-0.7	-0.7	0.3	-0.9
Qualifications: CSEs or equivalent	0.3	0.4	0.9	0.6	0.2	0.9	0.9	-0.9	0.9	-0.4	0.4	-0.4	-0.0	0.0	1.0	-0.2
Serious illness, injury or assault to yourself	3.3	4.1	8.8	1.7	-1.4	1.9	-1.2	-3.0	2.5	-2.2	-1.5	-1.9	-2.4	-2.0	-1.0	-2.4
High blood pressure	2.6	7.3	12.4	2.9	-2.2	3.2	-1.9	-2.8	3.2	-3.5	-0.6	-2.6	-3.4	-2.7	-0.3	-3.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.0	-0.4	1.1	0.4	1.5	-0.2	-0.2	0.5	1.2	-0.0	0.6	0.5	1.7	0.2
Multivitamins +/- minerals	1.0	1.2	2.4	0.8	-1.1	0.5	-1.2	-0.9	0.5	-0.5	-1.4	-1.1	-1.3	-1.4	-1.5	-1.3
Stomach or abdominal pain in last month	7.9	9.9	15.5	2.7	-2.6	2.6	-3.9	-3.6	2.6	-2.0	-2.9	-3.5	-3.3	-3.7	-3.5	-3.2
Supplements: Glucosamine	1.0	1.3	3.7	0.8	-1.9	0.1	-1.9	-0.6	-0.3	-0.6	-0.7	-1.3	-1.2	-1.2	-1.5	-1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	3.0	0.8	-1.0	0.4	-1.0	-1.1	-0.1	-0.1	-1.7	-0.8	-1.0	-1.0	-0.7	-1.1
Medication: Atenolol	2.5	3.1	6.8	2.2	-1.0	2.3	-0.9	-2.6	2.4	-2.1	-0.2	-1.5	-1.6	-1.6	0.5	-1.8
Medication: Levothyroxine sodium	0.2	0.4	1.8	-0.4	0.5	-0.3	0.2	1.3	-0.7	0.8	0.2	0.5	0.8	0.3	0.4	0.9
Sitting height	0.9	6.1	11.8	-3.1	1.1	-1.9	2.7	2.4	-1.8	1.4	1.1	3.4	3.1	2.9	2.1	3.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.0	0.5	-0.5	-0.0	0.3	-0.1	0.3	0.0	-0.2	-0.1	0.0	-0.4	-0.1
High blood pressure (mother)	1.0	1.4	4.0	0.4	-1.8	0.9	-1.2	-1.4	0.6	-1.3	2.0	-0.9	-1.5	-0.5	0.5	-1.2
Body mass index (BMI)	1.3	5.6	12.8	1.7	-2.5	1.8	-2.0	-3.5	1.8	-3.6	-1.7	-1.7	-3.0	-2.0	-1.3	-2.9
Impedance of leg (left)	1.2	5.9	12.5	-2.7	1.3	-2.5	1.5	2.8	-3.0	3.5	0.6	2.3	2.9	2.4	0.3	3.0
Leg predicted mass (left)	0.2	0.9	5.4	0.2	-0.5	0.8	0.9	-0.6	0.9	-2.3	0.6	0.4	-0.4	0.3	1.4	-0.3
Trunk fat mass	0.8	3.4	8.5	0.8	-2.4	1.2	-1.4	-2.4	1.1	-2.9	-2.1	-0.9	-2.2	-1.4	-1.6	-1.9
Waist circumference	0.8	2.8	9.1	0.7	-2.2	1.2	-0.9	-3.0	1.0	-2.6	-1.4	-0.9	-2.0	-1.1	-0.9	-1.7
Number of incorrect matches in round	0.9	1.5	3.8	0.9	-0.6	1.5	0.4	-1.6	1.9	-1.4	0.4	-0.9	-1.3	-0.5	1.3	-1.5
Past tobacco smoking	0.4	0.7	1.5	-1.1	0.6	-1.2	0.0	1.1	-0.4	0.5	0.4	1.2	0.9	0.7	-0.3	1.2
Alcohol usually taken with meals	0.7	1.2	2.9	-1.7	-0.2	-0.8	0.9	0.3	-1.7	1.6	0.9	1.0	0.9	1.1	0.8	1.1
Nervous feelings	0.3	0.6	1.9	0.6	0.9	1.2	0.9	-0.8	0.9	-0.8	0.4	-0.6	-0.1	-0.2	1.4	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	3.0	1.2	-0.9	1.7	-0.3	-1.7	0.9	-1.1	-0.6	-1.3	-0.9	-1.1	0.2	-1.1
Hearing difficulty/problems with background noise	0.8	1.2	5.8	1.1	-0.7	0.7	-0.9	-2.4	0.4	-0.9	0.5	-1.2	-1.3	-1.2	-0.4	-1.2
Hair/balding pattern: Pattern 2	0.3	0.4	3.2	-0.7	0.5	-0.7	-0.2	1.8	0.4	-0.4	0.0	0.2	0.2	0.1	-0.8	0.3
Had menopause	0.6	0.8	4.0	-0.3	-0.1	-0.5	0.6	1.0	-0.8	0.2	2.0	0.7	0.4	0.9	1.4	0.5
Had other major operations	0.3	0.3	1.2	-0.5	-0.1	-0.7	0.3	-0.6	-0.3	0.0	1.0	0.5	-0.0	0.7	1.1	-0.0
Forced vital capacity (FVC)	1.7	6.4	13.1	-1.8	2.8	-0.9	3.6	3.0	-1.4	2.0	1.9	2.2	3.3	2.6	2.9	2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.1	1.5	-1.5	0.6	-2.2	-0.8	1.0	-1.5	-0.7	-1.4	-1.9	-1.4	-1.4	-1.6
Ever unenthusiastic/disinterested for a whole week	3.8	4.7	10.9	2.7	-0.1	3.1	-0.1	-2.1	3.2	-3.3	-1.6	-2.0	-1.7	-2.0	-0.3	-2.2
Qualifications: None of the above	0.6	1.3	3.3	1.0	-1.0	0.4	-1.8	-0.8	0.8	-1.2	-1.0	-1.0	-1.3	-1.2	-1.0	-1.4
Financial difficulties in last 2 years	0.5	0.7	2.4	-0.3	-1.2	-0.8	-0.9	0.4	-1.2	0.3	-1.5	0.2	0.0	-0.2	-1.6	0.3
Mouth/teeth dental problems	1.7	2.7	4.4	-1.8	1.5	-1.5	1.5	1.8	-1.0	1.5	1.0	2.1	2.0	1.7	1.1	2.1
Heart attack	0.5	0.7	2.3	1.2	-0.0	1.3	1.0	-0.4	0.8	-0.9	0.5	-0.5	-0.0	-0.4	1.5	-0.4
Allergy	0.2	0.4	1.6	0.4	-0.9	-0.5	-1.3	-0.2	-0.2	-0.2	-0.9	0.1	-0.5	-0.3	-1.1	-0.3
Pain all over the body in last month	0.1	0.1	0.3	-0.6	-0.5	-0.1	0.6	-0.1	-0.4	-0.1	-0.1	0.2	-0.1	0.1	0.5	0.0
Diabetes (self-reported)	1.9	2.9	7.8	0.9	-2.8	1.2	-1.8	-2.4	0.7	-1.5	0.1	-1.6	-2.5	-1.5	-0.4	-2.2
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	9.4	-1.0	0.2	-0.7	1.7	1.1	-0.9	0.3	2.4	1.1	0.9	1.5	3.1	0.7
Medication: Ramipril	1.4	1.8	4.4	1.1	-1.2	1.9	0.1	-1.1	1.3	-2.1	0.6	-1.1	-1.2	-0.9	1.8	-1.4
Medication: Simvastatin	1.0	1.5	5.3	0.7	-0.8	1.5	0.0	-2.1	0.8	-2.3	-0.8	-0.9	-1.3	-1.0	0.5	-1.4
Fluid intelligence score	1.0	2.1	3.8	-1.4	1.3	-1.0	1.5	1.0	-1.1	1.1	1.5	1.9	1.8	1.4	1.6	1.8
Illnesses of siblings	0.7	0.9	2.3	-1.2	-0.4	-1.1	0.2	1.1	-1.1	1.5	0.3	1.2	0.8	1.0	0.1	1.2
Neuroticism score	0.4	0.9	2.7	1.1	0.2	1.6	0.3	-0.5	1.5	-1.6	-0.1	-0.7	-0.5	-0.7	0.9	-0.8
Weight	0.2	1.0	5.8	0.1	-1.4	0.6	0.1	-1.4	0.6	-2.4	-0.3	0.3	-1.0	-0.0	0.3	-0.7
Impedance of arm (right)	0.2	1.1	3.9	0.3	-0.7	0.5	-1.2	0.6	0.2	0.9	-1.7	-1.2	-0.5	-1.2	-2.0	-0.5
Arm fat percentage (right)	3.1	12.2	19.4	2.6	-3.5	2.9	-3.0	-4.4	2.9	-4.4	-3.4	-3.1	-4.2	-3.5	-2.8	-4.0
Trunk fat-free mass	0.5	3.0	8.6	-1.2	0.8	-0.6	2.6	0.8	-0.6	-0.6	2.2	2.2	1.7	2.1	2.9	1.8
Hip circumference	0.5	2.2	7.5	1.1	-1.1	1.5	-0.7	-1.8	1.6	-2.7	-1.3	-1.1	-1.6	-1.2	-0.6	-1.6
Time employed in main current job	0.6	0.6	2.2	-0.9	-1.1	-1.5	-0.6	0.3	-1.1	0.5	1.0	0.5	0.2	0.7	-0.1	0.6
Alcohol intake versus 10 years previously	0.8	1.2	4.2	1.5	-1.2	0.9	-0.6	-0.8	0.8	-2.1	0.1	-1.1	-1.3	-0.7	-0.2	-1.4
Father’s age at death	3.5	4.7	6.7	2.0	-2.1	2.3	-2.2	-1.9	1.9	-1.8	-1.6	-2.6	-2.6	-2.5	-1.8	-2.6
Worrier / anxious feelings	1.3	2.5	9.1	-0.3	1.6	0.3	2.9	0.7	-0.0	-0.4	1.6	1.4	1.6	1.7	3.0	1.3
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.5	9.1	2.5	-2.1	2.8	-2.1	-2.6	2.4	-2.8	-2.5	-2.9	-2.8	-2.8	-1.4	-3.0
Falls in the last year	3.6	4.9	7.3	1.5	-2.2	1.7	-2.3	-1.3	2.1	-2.4	-2.6	-2.1	-2.7	-2.3	-2.5	-2.5
Hair/balding pattern: Pattern 3	1.3	1.9	3.6	-0.9	1.8	-0.8	1.9	-0.3	-1.3	1.1	1.2	1.3	1.7	1.3	1.9	1.4
Number of live births	1.8	2.6	7.0	-1.4	0.6	-1.7	1.0	1.6	-2.3	2.6	1.2	1.3	1.5	1.8	0.9	1.7
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	10.8	-1.2	2.5	-0.4	3.3	2.9	-0.7	1.2	1.5	1.6	2.6	2.0	2.8	2.2
Pulse rate	0.5	0.9	5.9	0.2	0.0	0.5	-0.5	0.5	0.6	-0.1	-2.4	-0.4	-0.3	-1.0	-1.8	-0.2
Happiness	5.9	7.1	11.9	3.2	-1.1	3.3	-1.5	-2.2	3.5	-3.3	-2.2	-3.1	-2.6	-3.1	-1.0	-3.0
Noisy workplace	0.4	0.5	2.6	-0.3	1.1	-0.5	0.8	-0.4	-0.1	0.2	1.6	0.3	0.3	0.7	0.8	0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.4	-0.2	-0.5	-0.5	0.2	0.2	-0.6	0.2	0.0	0.1	0.3	0.1	-0.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	3.8	-0.1	-0.8	0.5	-0.5	-1.9	-0.3	-0.1	0.3	-0.8	-0.1	-0.4	0.4	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	1.2	0.4	-0.0	0.2	0.2	-0.6	-0.3	0.3	1.1	-0.6	-0.5	0.1	0.6	-0.6
Asthma	0.2	0.3	0.7	-0.4	0.8	-0.2	0.8	0.8	0.2	-0.0	0.6	0.7	0.5	0.5	0.4	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.9	0.2	1.3	0.5	1.4	0.6	0.9	-0.6	-0.2	0.4	0.5	0.4	1.2	0.2
Medication: Cholesterol lowering	1.3	2.0	6.3	1.2	-0.9	2.4	0.6	-1.2	1.5	-2.5	-0.2	-1.2	-1.2	-0.9	1.3	-1.5
Depression (self-reported)	2.5	3.0	6.0	1.5	-2.2	1.7	-1.3	-2.2	1.2	-2.1	0.1	-1.5	-2.5	-1.4	0.2	-2.4
Medication: Lansoprazole	2.4	2.7	5.0	1.0	-2.2	1.1	-2.2	-1.5	0.5	-0.9	-1.7	-1.8	-1.9	-1.9	-1.9	-1.8
Prospective memory result	1.4	1.7	3.8	1.0	-1.0	1.9	-0.0	-1.5	1.3	-1.9	-0.1	-1.6	-1.2	-1.0	1.0	-1.6
Lung cancer (father)	0.3	0.4	1.4	0.1	0.5	-0.1	0.8	1.2	-0.2	0.5	0.4	0.6	0.7	0.4	0.7	0.7
Illnesses of mother	2.4	3.0	5.7	-1.8	1.5	-1.8	1.5	2.4	-1.8	2.1	-0.0	1.9	2.0	1.8	0.6	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.6	-0.9	1.3	0.0	2.1	1.3	-0.2	0.7	-0.1	0.7	1.5	0.9	1.4	1.2
Pulse wave Arterial Stiffness index	0.6	0.6	1.8	0.6	-0.5	0.3	-1.3	0.4	0.5	-0.1	-0.2	-1.1	-1.1	-1.0	-1.1	-0.9
Impedance of arm (left)	0.2	0.8	2.7	-0.5	-0.5	-0.4	-0.6	1.2	-0.7	1.6	-1.2	-0.3	0.1	-0.3	-1.6	0.2
Arm fat mass (right)	1.3	5.2	12.9	1.6	-2.4	1.9	-1.6	-3.2	1.9	-3.6	-1.9	-1.6	-2.7	-1.9	-1.3	-2.6
Trunk predicted mass	0.6	3.2	8.9	-1.2	0.8	-0.6	2.6	0.8	-0.6	-0.5	2.2	2.2	1.7	2.1	3.0	1.9
Standing height	1.5	14.7	22.8	-3.8	2.5	-2.6	4.7	4.4	-2.7	2.5	3.1	4.6	4.5	4.5	3.8	4.8
Length of working week for main job	0.1	0.1	0.4	-0.2	-0.5	-0.3	-0.0	-0.3	-0.1	0.4	0.6	0.1	0.1	0.2	-0.6	0.4
Exposure to tobacco smoke at home	0.2	0.2	1.1	-0.5	-0.6	-0.4	-0.4	-0.5	-1.1	0.5	0.3	-0.1	-0.1	-0.1	-0.6	0.1
Breastfed as a baby	1.2	1.5	2.9	-1.2	0.5	-1.1	1.0	0.9	-1.4	1.7	1.4	1.1	1.3	1.2	1.2	1.4
Tense / ‘highly strung’	0.8	1.3	4.7	-0.4	1.7	0.1	2.0	1.0	0.0	0.1	0.5	1.0	1.1	1.1	2.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.8	0.7	0.7	2.0	1.5	-1.5	1.7	-1.6	-1.2	-0.2	-0.1	-0.8	0.6	-0.4
Hair/balding pattern: Pattern 4	1.3	3.3	8.0	-1.3	1.6	-2.0	0.9	2.8	-2.3	2.3	1.1	1.8	1.8	1.9	0.7	1.8
Birth weight of first child	2.4	4.4	7.0	-2.3	1.5	-1.3	2.6	1.4	-1.7	1.9	1.7	2.5	2.6	2.3	2.1	2.6
Peak expiratory flow (PEF)	3.4	7.8	15.8	-1.9	3.2	-1.5	3.9	4.0	-1.2	1.4	2.0	2.8	3.3	3.0	3.3	3.0
Pulse wave reflection index	0.8	1.0	3.0	0.7	-1.3	0.3	-1.7	-0.1	0.3	-0.5	0.4	-1.3	-1.5	-0.9	-0.8	-1.4
Ever highly irritable/argumentative for 2 days	1.7	2.0	4.9	1.0	-0.5	1.3	-1.1	-1.8	1.6	-1.2	-2.2	-1.2	-1.4	-1.7	-1.1	-1.6
Loud music exposure frequency	2.7	2.9	4.0	1.5	-1.7	1.7	-1.5	-1.4	1.6	-2.0	-1.7	-2.0	-1.9	-1.7	-1.5	-1.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	3.2	-0.9	0.5	-0.7	1.4	1.8	-0.3	0.3	-0.9	1.3	0.9	0.7	0.1	0.9
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	3.3	1.1	-0.5	0.9	-0.4	-1.3	1.1	-1.8	-1.7	-0.8	-0.8	-1.0	-0.5	-1.0
Blood clot in the leg (DVT)	0.2	0.3	0.8	0.5	-0.3	0.6	-0.1	0.7	0.6	-0.8	-0.2	-0.9	-0.4	-0.7	-0.3	-0.5
Medication: Paracetamol	0.7	1.2	5.7	-0.8	1.1	0.5	2.4	-0.4	0.6	-0.6	0.3	1.0	1.2	1.1	1.8	1.0
Headache pain in last month	0.3	0.5	1.5	0.6	0.8	1.0	0.5	-0.8	0.9	-1.2	-0.7	-0.3	-0.1	-0.5	0.2	-0.3
Medication for cholesterol, blood pressure or diabetes	2.4	4.0	11.0	-2.0	1.5	-3.1	-0.2	2.0	-2.3	3.3	0.5	1.7	1.9	1.5	-1.5	2.2
Glaucoma (self-reported)	0.2	0.2	0.7	0.5	0.8	0.5	0.7	0.7	0.1	-0.1	-0.0	-0.1	0.4	0.1	0.7	0.2
Gout (self-reported)	0.1	0.1	0.4	0.1	-0.1	-0.3	-0.1	-0.6	-0.2	-0.5	0.1	-0.1	-0.3	-0.1	0.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.3	-0.1	0.8	-0.2	0.6	0.7	-0.3	0.1	1.0	0.8	0.8	0.6	1.1	0.8
Medication: Amlodipine	1.3	1.9	4.8	1.4	-0.4	2.2	0.2	-1.7	2.0	-1.9	0.3	-1.3	-1.3	-1.1	0.8	-1.5
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.0	-1.0	-0.6	-1.0	-0.4	-0.3	-0.1	0.3	0.4	0.6	-0.2	0.4	-1.0	0.3
Birth weight	15.2	33.0	49.1	-6.1	3.8	-5.3	6.1	5.3	-5.6	4.4	4.4	6.9	6.7	6.9	4.9	7.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	0.0	-0.1	-0.7	-0.8	0.9	-0.3	0.7	-0.3	0.1	-0.1	0.0	-0.7	0.1
High blood pressure (siblings)	0.9	1.3	2.7	1.2	-0.1	1.6	-0.1	-1.4	1.1	-1.6	-0.1	-1.4	-1.0	-1.2	0.4	-1.3
Forced vital capacity (FVC), Best measure	0.7	2.6	7.0	-1.5	1.7	-0.5	2.7	1.6	-0.7	1.6	0.4	1.3	2.3	1.6	1.7	2.0
Body fat percentage	1.5	6.0	10.0	1.3	-3.0	1.6	-2.2	-3.1	1.4	-3.2	-2.7	-1.8	-3.0	-2.1	-2.3	-2.8
Leg fat percentage (right)	1.0	3.5	8.1	0.9	-2.3	1.1	-1.5	-2.9	0.8	-2.5	-2.4	-1.3	-2.1	-1.5	-1.7	-2.0
Arm fat-free mass (right)	0.6	3.1	7.7	-1.5	0.6	-1.0	2.4	0.7	-0.9	-0.6	2.3	2.4	1.5	2.3	2.8	1.7
Exposure to tobacco smoke outside home	0.6	0.8	1.9	1.4	0.6	1.4	0.6	-0.9	1.2	-1.0	0.1	-0.6	-0.2	-0.6	1.2	-0.5
Comparative body size at age 10	1.2	3.4	8.1	-1.5	0.2	-1.4	1.8	1.1	-1.5	1.7	2.8	2.1	1.6	2.4	2.7	1.6
Number of full brothers	0.2	0.2	0.8	0.9	0.9	0.2	-0.2	0.6	0.4	-0.1	-0.1	-0.5	0.2	-0.4	-0.4	0.1
Worry too long after embarrassment	0.4	0.8	3.3	0.2	-0.6	0.2	-1.1	-1.0	0.9	-0.8	1.8	-0.3	-1.0	-0.2	0.8	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.6	0.0	0.8	0.2	-0.8	0.3	-0.6	-0.4	-0.7	-0.7	-0.4	0.1	-0.8
Wheeze or whistling in the chest in last year	0.4	0.8	3.5	0.8	-0.5	0.7	-0.4	-1.9	0.5	-0.6	-1.3	-1.1	-0.4	-0.8	-0.6	-0.5
Number of children fathered	2.5	2.9	5.1	-2.1	0.4	-2.3	0.7	1.3	-2.0	2.1	0.9	2.0	1.8	2.0	0.8	2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	0.1	-0.3	-0.2	0.1	-0.3	-0.2	0.3	0.5	0.2	0.1	0.3	0.6	0.1
Age at first live birth	0.4	0.6	1.6	1.0	0.2	1.3	0.5	0.1	1.3	-1.0	-0.4	-1.1	-0.5	-0.6	0.1	-0.8
Pulse wave peak to peak time	1.0	1.2	3.4	-0.8	0.8	-0.4	1.9	-0.1	-0.6	0.3	0.5	1.4	1.4	1.3	1.5	1.2
Health satisfaction	7.4	9.6	15.8	3.5	-1.6	3.9	-1.7	-3.2	3.4	-3.0	-2.2	-4.0	-3.4	-3.6	-1.3	-3.8
Shortness of breath walking on level ground	0.6	0.7	2.6	0.9	-0.4	1.1	-0.1	-1.1	0.5	-0.5	-1.6	-1.0	-0.3	-1.0	-0.8	-0.5
Qualifications: College or University degree	1.6	5.0	8.6	-2.2	1.7	-1.9	2.1	2.5	-2.3	2.5	1.0	2.5	2.9	2.3	1.1	2.9
Eye problems/disorders: None of the above	0.9	1.1	1.9	1.0	-0.6	0.9	-0.8	-1.2	0.9	-1.4	-0.5	-1.3	-1.2	-1.1	-1.2	-1.2
Mouth/teeth dental problems: Loose teeth	2.1	2.5	5.3	1.5	-2.3	1.0	-2.2	-1.9	0.3	-0.9	-0.2	-1.8	-2.0	-1.6	-1.3	-1.7
Emphysema/chronic bronchitis	0.1	0.1	0.6	-0.1	-0.2	0.2	0.8	-0.1	-0.1	-0.2	-0.1	-0.3	0.2	0.1	0.3	0.1
Medication for pain relief, constipation, heartburn	0.8	1.3	5.4	-0.2	-0.5	-1.5	-2.2	0.6	-1.4	1.3	0.1	-0.2	-0.2	-0.5	-2.3	0.2
Neck or shoulder pain in last month	1.3	1.9	3.4	1.3	-0.0	1.5	-0.8	-1.6	1.6	-1.0	-1.9	-1.5	-1.3	-1.5	-1.1	-1.6
Medication: Blood pressure	2.0	3.6	8.4	2.1	-1.0	2.9	0.3	-1.6	2.3	-2.9	0.3	-1.5	-1.8	-1.3	2.2	-2.1
Angina (self-reported)	1.5	1.9	3.9	1.4	-0.7	1.6	-0.2	-2.0	1.9	-2.0	0.5	-1.0	-1.6	-0.9	1.1	-1.8
Migraine (self-reported)	1.9	2.4	5.0	-1.6	1.7	-1.0	2.0	1.2	-1.9	0.7	0.5	1.4	2.2	1.5	0.9	2.1
Medication: Ibuprofen	0.5	0.6	2.0	0.3	1.3	0.6	1.3	0.6	0.7	-0.6	0.1	0.3	0.7	0.2	1.4	0.3
Medication: Allopurinol	0.3	0.4	1.8	0.0	-0.4	-0.9	-0.9	0.4	-0.9	0.2	-0.2	-0.2	-0.2	-0.2	-1.4	-0.1
Medication: Omeprazole	0.3	0.3	1.6	-0.4	-1.3	-0.1	-0.2	-0.5	-0.2	0.6	0.9	-0.1	-0.5	0.3	0.7	-0.4
Medication: Seretide 50 evohaler	0.2	0.2	1.0	0.1	-1.0	0.4	0.1	-0.4	0.6	-0.4	-0.5	-0.2	-0.7	-0.1	-0.5	-0.5
Mean time to correctly identify matches	0.1	0.2	0.4	-0.6	-0.6	-0.4	-0.0	0.1	-0.6	0.6	0.4	0.5	0.1	0.6	0.4	0.4
Heart disease (mother)	2.9	3.5	9.3	1.6	-3.1	1.9	-1.6	-1.5	1.3	-2.1	0.0	-2.2	-2.4	-1.7	0.2	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	5.6	-1.3	1.8	-1.8	1.6	2.4	-1.6	1.6	0.8	1.9	2.0	2.1	0.8	2.0
Whole body fat mass	0.8	3.2	9.5	0.9	-2.1	1.4	-1.1	-2.5	1.2	-3.1	-1.8	-1.0	-2.2	-1.3	-1.1	-2.0
Leg fat mass (right)	0.6	2.5	8.4	0.8	-2.0	1.2	-0.8	-2.5	1.0	-2.9	-1.6	-0.7	-1.8	-1.0	-0.7	-1.7
Arm predicted mass (right)	0.5	2.7	6.3	-1.4	0.4	-0.9	2.1	0.5	-0.8	-0.7	2.3	2.3	1.3	2.2	2.5	1.6
Pulse rate, automated reading	0.2	0.7	1.9	0.9	-0.1	1.2	-0.0	-0.4	0.5	-0.4	-1.4	-1.1	-0.7	-1.1	-1.0	-0.8
Alcohol intake frequency.	2.7	6.2	10.2	2.0	-2.8	1.7	-3.2	-2.3	1.9	-2.5	-1.9	-2.4	-3.2	-2.5	-2.6	-2.8
Comparative height size at age 10	0.7	4.1	7.5	-2.7	-0.8	-2.0	1.4	2.6	-2.2	1.9	1.1	2.4	2.0	2.5	0.6	2.6
Number of full sisters	0.2	0.2	0.6	-0.3	-0.5	-0.2	0.0	0.5	-0.8	0.0	-0.6	0.1	0.6	0.0	-0.2	0.6
Suffer from ‘nerves’	1.5	2.3	4.1	-1.0	1.2	-1.0	1.9	1.0	-1.6	2.0	1.2	1.4	1.8	1.7	1.6	1.7
Overall health rating	2.4	5.2	8.9	2.5	-0.9	2.3	-1.6	-2.1	2.0	-1.8	-2.4	-3.0	-2.5	-2.8	-2.3	-2.7
Chest pain or discomfort	0.1	0.2	0.7	-0.1	-0.5	0.6	0.5	-0.8	0.4	0.0	0.0	-0.2	-0.4	-0.0	0.6	-0.4
Had major operations	0.8	1.0	3.1	1.3	-0.6	1.8	0.2	-0.9	1.0	-1.1	0.3	-1.3	-0.8	-1.1	0.4	-0.8
Age at last live birth	0.4	0.5	1.4	1.2	0.1	1.2	0.4	0.2	1.1	-0.6	-0.4	-1.1	-0.5	-0.3	0.3	-0.9
Family relationship satisfaction	2.5	3.1	7.7	2.3	-0.1	2.7	0.0	-1.5	2.5	-2.8	-0.7	-1.8	-1.1	-1.9	0.6	-1.6
Leg pain on walking	0.6	0.8	2.0	0.9	-0.9	1.0	-0.7	-1.4	0.4	-0.7	-0.0	-1.3	-1.0	-0.9	-0.2	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.8	1.7	-0.4	0.9	-0.9	-0.9	1.4	-1.3	0.2	-1.0	-1.1	-0.9	-0.5	-1.1
Commuting to job workplace: Car/motor vehicle	0.8	1.0	3.8	-0.6	0.4	-1.1	-0.2	0.6	-1.2	1.9	-1.0	0.6	0.7	0.4	-1.6	0.8
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	1.0	-0.0	0.2	-0.5	-0.5	0.4	-0.2	0.6	1.0	0.4	-0.2	0.2	0.2	-0.1
Medication: Aspirin	0.3	0.4	1.3	0.2	-0.3	0.8	0.1	-1.1	0.6	-0.7	-0.3	-0.2	-0.8	-0.4	0.5	-0.9
Supplements: Vitamin C	1.1	1.3	4.2	0.9	-1.6	0.3	-2.0	-1.5	0.1	-0.1	-0.6	-1.2	-1.1	-1.2	-1.4	-1.0
Knee pain experienced in last month	4.7	7.2	11.1	2.8	-0.9	2.5	-3.1	-2.8	2.7	-2.3	-1.9	-3.3	-2.9	-3.1	-2.5	-3.2
Hypertension (Self-reported)	2.8	7.7	13.1	3.1	-2.1	3.4	-1.8	-2.8	3.4	-3.6	-0.3	-2.7	-3.4	-2.8	-0.1	-3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.5	4.5	1.7	-1.1	2.0	-1.5	-2.1	1.4	-1.4	-1.2	-1.9	-1.5	-2.0	-0.3	-1.7
Illnesses of father: Heart disease	0.6	0.8	2.1	0.5	-0.3	1.3	0.2	-1.4	1.2	-1.3	-1.1	-0.6	-0.7	-0.6	-0.1	-0.8
Illnesses of siblings: Diabetes	1.0	1.2	4.7	0.7	-0.6	0.7	-1.3	-1.1	1.1	-2.2	-0.6	-0.9	-1.1	-1.0	-1.0	-1.0
Smoking status: Previous	0.3	0.5	0.9	0.7	-0.9	0.9	0.0	-0.7	0.1	-0.6	0.1	-0.9	-0.8	-0.4	0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.4	9.4	-2.6	1.5	-1.8	3.0	2.9	-2.0	1.7	2.4	2.6	3.0	3.1	2.7	3.0
Whole body fat-free mass	0.3	1.7	6.2	-0.7	0.3	-0.0	2.0	0.3	0.0	-1.4	1.7	1.6	0.9	1.5	2.5	1.0
Leg fat-free mass (right)	0.2	1.1	5.6	0.4	-0.5	1.0	1.0	-0.5	1.1	-2.4	0.9	0.3	-0.5	0.2	1.7	-0.4
Arm fat percentage (left)	2.4	9.7	15.3	2.2	-3.5	2.4	-2.8	-3.9	2.3	-3.9	-2.9	-2.7	-3.9	-3.0	-2.6	-3.7
Average weekly red wine intake	0.4	0.5	2.4	-0.6	-1.6	-0.5	-0.2	-0.6	-1.0	0.5	1.3	0.0	-0.4	0.4	0.5	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.2	1.0	-0.5	0.2	-0.6	-0.1	0.0	-0.4	1.0	-0.1	0.1	-0.0	0.4	-0.2	0.0
Mood swings	0.9	1.6	3.6	0.9	-1.3	1.5	-0.9	-1.9	1.4	-1.9	-0.2	-1.1	-1.3	-1.0	0.4	-1.4
Loneliness, isolation	7.4	10.2	13.8	3.4	-2.5	2.9	-3.3	-3.0	3.1	-2.9	-2.7	-3.5	-3.7	-3.7	-3.0	-3.7
Long-standing illness, disability or infirmity	2.6	4.0	6.9	2.6	-1.3	1.9	-1.6	-1.9	1.6	-1.7	-1.7	-2.4	-2.0	-2.4	-2.3	-2.0
Ever had bowel cancer screening	0.5	0.6	2.0	1.4	0.5	1.4	0.4	-0.6	1.0	-0.2	-0.7	-0.9	-0.3	-0.8	0.2	-0.7
Diabetes diagnosed by doctor	3.0	5.0	10.7	1.5	-3.3	1.4	-2.7	-3.1	0.7	-1.4	-0.6	-2.5	-3.0	-2.2	-1.8	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.6	1.2	-0.1	1.3	0.1	-0.8	1.0	-1.2	-0.1	-0.7	-0.5	-0.6	0.9	-0.8
Friendships satisfaction	0.1	0.2	0.7	0.3	-0.2	0.7	-0.3	0.4	0.2	-0.6	-0.1	-0.6	-0.1	-0.8	-0.1	-0.2
Qualifications: nursing, teaching	1.5	2.3	5.2	-1.3	-0.7	-0.9	1.7	1.4	-2.0	1.4	2.2	1.1	1.1	1.6	2.3	1.2
Commuting to job workplace: Walk	0.5	0.6	1.7	-0.3	0.8	0.0	1.3	1.3	0.0	-0.3	0.1	0.6	0.7	0.6	1.3	0.5
Eye problems/disorders: Cataract	1.0	1.1	2.4	1.5	-0.4	1.5	-0.5	-1.4	1.5	-0.3	-0.7	-1.3	-0.9	-1.1	0.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.7	1.2	-0.4	0.7	-1.0	0.6	0.3	-0.3	-0.9	-1.1	-0.8	-1.1	-1.3	-0.8
Medication for cholesterol	2.6	4.0	9.9	-2.2	0.5	-2.1	1.4	3.1	-2.5	2.1	-0.5	2.0	2.3	2.0	0.1	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.3	0.1	-0.1	0.7	0.5	-0.9	-0.4	-0.5	-0.0	-0.6	-0.1	-0.3	1.1	-0.4
Back pain experienced in last month	1.5	2.2	4.2	1.4	-0.8	1.6	-1.1	-2.0	1.4	-1.6	-1.0	-2.0	-1.6	-1.5	-0.8	-1.8
Mineral and other dietary supplements	0.4	0.5	1.6	-0.5	1.0	0.1	1.3	-0.3	0.6	-0.7	0.1	0.8	0.7	0.5	1.2	0.6
Breast cancer (self-reported)	0.5	0.6	1.2	0.9	-0.7	1.0	-0.3	-0.4	0.9	-0.3	0.6	-1.0	-1.1	-0.8	0.2	-1.0
Asthma (self-reported)	0.1	0.2	0.4	-0.4	0.6	-0.3	0.6	0.7	0.0	0.2	0.5	0.7	0.5	0.4	0.1	0.6
Osteoporosis (self-reported)	1.0	1.3	4.4	-0.7	1.1	-1.2	0.9	0.8	-1.2	2.1	1.2	0.8	0.9	1.2	1.1	0.7
Osteoarthritis (self-reported)	1.5	1.9	3.3	1.3	-1.8	0.9	-1.6	-1.3	0.9	-1.3	-0.9	-1.4	-1.8	-1.3	-1.6	-1.5
Medication: Aspirin	0.5	0.7	1.9	0.3	-0.9	0.8	-0.6	-1.4	0.6	-0.8	-0.7	-0.5	-1.2	-0.8	0.1	-1.2
Medication: Gliclazide	7.3	8.2	13.5	2.5	-3.7	2.5	-3.0	-3.7	1.4	-2.8	-1.0	-3.4	-3.5	-3.0	-1.9	-3.3
Illnesses of father: None of the above (group 1)	1.5	1.8	3.6	-1.1	0.8	-1.5	0.9	1.6	-1.4	1.4	0.4	1.9	1.6	1.4	0.5	1.9
Smoking status: Current	0.4	0.6	1.2	-0.6	0.9	-0.7	0.9	0.4	-0.8	1.1	1.1	0.6	0.7	1.0	0.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.7	-0.5	1.5	0.1	1.9	1.1	-0.1	-0.2	0.1	0.5	1.1	0.6	1.3	0.6
Whole body water mass	0.3	1.6	5.6	-0.7	0.2	-0.0	1.9	0.2	-0.0	-1.3	1.7	1.5	0.8	1.4	2.4	1.0
Leg predicted mass (right)	0.2	1.1	5.1	0.3	-0.4	0.9	1.1	-0.4	0.9	-2.3	1.1	0.4	-0.4	0.3	1.9	-0.3
Arm fat mass (left)	1.0	4.1	11.3	1.4	-2.3	1.7	-1.4	-2.8	1.6	-3.4	-1.6	-1.4	-2.5	-1.6	-1.0	-2.3
Number of self-reported non-cancer illnesses	0.9	1.5	3.6	1.5	-0.8	1.6	0.2	-1.5	1.2	-1.9	0.5	-1.0	-1.2	-0.9	0.9	-1.3
Average weekly champagne plus white wine intake	0.4	0.5	1.0	0.4	-0.6	0.7	-0.9	-0.5	0.4	0.3	-1.0	-1.0	-0.7	-0.8	-0.9	-0.7
Miserableness	0.3	0.5	1.6	0.4	0.3	1.1	0.3	-0.8	1.2	-1.1	-1.3	-0.2	-0.0	-0.6	-0.1	-0.3
Guilty feelings	0.5	0.7	3.1	0.4	1.0	0.4	1.0	0.5	0.6	-0.5	1.4	0.2	0.2	0.5	1.8	-0.0
Wears glasses or contact lenses	0.7	0.8	2.1	-0.9	-1.4	-1.3	-1.2	-0.4	-1.0	0.4	-1.1	0.7	-0.5	0.0	-1.2	-0.2
Ever taken oral contraceptive pill	2.6	2.9	7.2	1.6	-2.0	1.1	-2.2	-2.7	0.6	-0.8	-1.0	-2.1	-1.8	-2.0	-1.4	-1.7
Hearing aid user	1.0	1.1	4.2	-0.9	-1.0	-1.2	-0.7	0.3	-1.7	1.5	2.1	0.6	-0.0	0.8	0.4	0.4
Mother’s age at death	1.9	2.4	6.0	-0.6	2.4	-0.6	2.3	1.9	-0.6	0.8	1.0	1.2	2.0	1.4	1.8	1.7
Financial situation satisfaction	0.1	0.2	0.7	0.2	0.3	-0.5	-0.2	0.2	-0.9	0.5	0.7	0.0	0.3	0.2	0.3	0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	-0.8	-0.6	-1.0	-0.7	-0.1	-0.7	0.6	0.5	0.5	-0.1	0.3	-0.5	0.2
Commuting to job workplace: Public transport	0.5	0.6	1.3	0.4	-0.9	0.3	-0.9	-1.1	0.1	-0.5	-0.3	-1.0	-1.1	-0.7	-1.1	-1.0
Eye problems/disorders: Glaucoma	0.7	0.8	2.1	-0.4	1.3	-0.4	1.0	1.4	-0.6	0.4	0.2	0.9	1.2	0.8	0.8	1.1
Medication: Blood pressure	1.0	1.9	4.7	1.7	0.3	1.8	-0.6	-1.7	2.2	-1.6	0.3	-1.3	-1.3	-1.3	0.0	-1.5
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.3	1.0	1.5	1.4	1.1	-0.9	0.8	-0.4	-0.7	-0.9	0.5	-0.5	0.4	-0.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.3	1.1	0.3	0.6	-0.9	0.6	0.3	0.3	-1.7	-1.1	-0.4	-1.0	-1.8	-0.6
High cholesterol (Self-reported)	0.7	1.2	2.4	1.0	-1.2	1.3	-0.4	-1.5	0.6	-1.6	0.1	-1.0	-1.5	-0.8	0.5	-1.5
Medication: Bendroflumethiazide	0.5	0.8	2.1	1.2	0.3	1.1	-0.2	0.1	1.4	-1.5	0.6	-0.5	-0.8	-0.7	1.1	-1.0
Medication: Paracetamol	0.8	1.3	5.3	-0.6	1.5	0.5	2.3	0.3	0.5	-0.4	0.3	0.8	1.3	1.1	1.8	1.0
Medication: Lisinopril	0.6	0.8	2.4	1.3	0.2	1.6	1.2	-0.6	0.9	-1.4	-0.5	-0.8	-0.0	-0.3	1.1	-0.4
Medication: Atorvastatin	0.3	0.4	2.0	0.7	-1.4	0.7	-0.3	-0.5	0.0	-0.1	0.7	-0.7	-0.7	-0.3	0.1	-0.5
Illnesses of father: High blood pressure	2.6	3.2	6.9	2.5	-0.2	2.6	-0.7	-1.1	1.9	-1.3	-2.0	-2.4	-1.4	-2.2	-1.0	-1.9
Alcohol drinker status: Never	0.2	0.3	1.2	-0.0	-0.8	-0.1	-0.9	-0.6	-0.3	0.2	0.2	-0.4	-0.2	-0.2	-1.1	0.1
Ever smoked	1.0	1.7	3.5	1.4	-0.9	1.3	-0.9	-1.9	0.6	-0.5	-1.5	-1.8	-1.4	-1.3	-0.8	-1.7
Basal metabolic rate	0.2	1.1	4.0	-0.5	-0.0	0.2	1.6	-0.2	0.2	-1.7	1.2	1.3	0.5	1.1	2.0	0.6
Leg fat percentage (left)	0.9	3.1	6.6	1.1	-2.1	1.1	-1.4	-2.6	0.8	-2.5	-2.1	-1.2	-2.1	-1.4	-1.4	-2.0
Arm fat-free mass (left)	0.4	2.1	6.0	-1.2	0.5	-0.6	2.1	0.3	-0.4	-0.9	1.7	2.1	1.2	1.9	2.5	1.4
Number of operations (self-reported)	1.1	1.6	2.8	1.2	-1.7	1.5	-0.3	-1.4	1.4	-1.4	0.3	-1.1	-1.6	-1.0	1.0	-1.6
Average weekly beer plus cider intake	0.8	1.1	2.7	-0.5	0.4	-1.6	-0.3	1.4	-1.6	1.5	-0.2	0.8	0.8	0.5	-1.3	1.0
Irritability	1.7	2.8	5.1	1.7	-1.6	1.9	-1.2	-1.7	1.5	-2.3	-0.4	-1.6	-2.1	-1.9	0.1	-2.2
Risk taking	0.4	0.6	2.6	0.8	0.5	0.9	0.5	0.4	0.2	0.3	1.5	-0.4	0.2	0.0	1.6	-0.1
Ever had prostate specific antigen (PSA) test	2.7	3.1	8.3	0.6	-2.9	0.8	-1.9	-2.3	1.0	-1.9	-1.4	-1.5	-2.2	-1.5	-1.4	-1.9
Fractured/broken bones in last 5 years	2.7	3.5	6.9	-1.9	2.1	-1.7	2.6	1.6	-1.1	1.8	0.6	2.5	2.0	2.3	1.4	1.8
Age started oral contraceptive pill	1.5	1.9	5.0	-1.5	0.6	-1.8	0.7	0.9	-1.8	2.2	1.1	1.2	1.3	1.4	0.6	1.5
Diastolic blood pressure, automated reading	0.0	0.1	0.8	-0.3	-0.6	-0.1	-0.4	-0.3	-0.2	-0.3	-0.2	0.1	-0.4	0.0	-0.9	-0.2
Ever depressed for a whole week	0.9	1.2	2.9	1.1	-0.5	1.2	-0.3	-1.5	1.7	-1.7	-0.7	-0.6	-1.1	-0.8	-0.3	-1.2
Unable to work because of sickness or disability	0.4	0.5	1.2	0.7	-1.1	0.8	-0.4	-0.7	0.2	-0.6	-0.1	-1.0	-1.1	-0.4	0.1	-1.1
Commuting to job workplace: Cycle	2.6	3.1	4.8	-1.4	1.3	-1.6	1.4	2.0	-2.0	1.9	2.2	1.5	1.9	2.0	1.6	1.9
Myopia	0.3	0.4	0.7	0.6	-0.7	0.6	-0.3	-0.8	0.2	-0.7	-0.1	-0.8	-0.7	-0.7	-0.4	-0.6
Vascular/heart problems diagnosed by doctor	2.1	5.9	11.2	-2.6	2.3	-2.9	1.6	2.5	-3.0	3.3	0.1	2.2	3.0	2.3	-0.2	2.9
Cholesterol lowering medication	2.7	4.0	14.0	1.4	-1.9	1.1	-2.4	-3.7	0.8	-2.0	-0.6	-1.9	-2.5	-2.0	-1.3	-2.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.7	-0.1	-1.7	0.3	-0.5	-0.9	0.3	0.5	0.3	-0.5	-1.1	-0.1	0.1	-0.9
Pain experienced in last month	2.3	3.8	7.8	-2.0	-0.0	-2.1	1.2	2.8	-1.9	1.5	1.6	2.5	2.1	2.2	0.9	2.6
Supplements: Calcium	0.7	0.8	3.4	-0.4	-0.8	-0.8	-1.7	-0.5	0.1	0.7	-0.9	-0.1	-0.7	-0.5	-1.8	-0.5
Basal cell carcinoma (self-reported)	0.4	0.5	2.4	1.1	0.0	0.6	0.5	-0.7	-0.1	0.1	1.6	-0.8	-0.1	-0.1	1.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.6	2.4	1.0	-0.2	1.1	0.9	-0.4	0.6	-0.8	0.7	-0.4	-0.1	-0.2	1.5	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	0.3	-0.4	0.5	-0.1	0.9	0.4	-0.7	-0.2	-0.8	-0.4	-0.6	-0.2	-0.5
Heart disease (siblings)	0.5	0.6	1.7	1.1	-0.0	0.8	-0.1	-0.8	0.4	-1.3	0.8	-0.7	-0.8	-0.5	0.8	-1.0
Alcohol drinker status: Previous	0.2	0.2	0.8	0.1	0.3	0.2	0.6	-0.5	-0.3	0.5	0.9	0.1	0.2	0.2	0.8	0.1
Pack years of smoking	0.2	0.4	0.9	0.5	1.0	0.7	0.8	-0.0	0.6	-0.9	-0.8	-0.1	0.4	-0.3	0.4	0.2
Impedance of whole body	0.4	2.1	7.2	-1.6	0.3	-1.5	0.2	2.1	-1.8	2.7	-0.5	0.9	1.4	0.9	-1.0	1.6
Leg fat mass (left)	0.6	2.3	8.2	0.8	-1.8	1.2	-0.7	-2.3	1.0	-2.9	-1.5	-0.7	-1.8	-1.0	-0.6	-1.6
Arm predicted mass (left)	0.5	2.5	7.2	-1.3	0.5	-0.7	2.1	0.5	-0.6	-0.8	2.1	2.2	1.3	2.0	2.7	1.5