Best TWAS P=2.27e-10 · Best GWAS P=6.3e-12 conditioned to 0.000678
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | PLAC9 | 0.13 | 0.02 | enet | 14 | 0.01 | 1.4e-01 | 3.8 | -5.8 | 6.0e-09 | 0.66 | 0.08 | 0.53 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | FAM213A | 0.29 | 0.13 | lasso | 4 | 0.10 | 1.0e-03 | 5.0 | 6.0 | 2.2e-09 | -0.68 | 0.05 | 0.79 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | RP11-137H2.6 | 0.20 | 0.11 | lasso | 5 | 0.08 | 4.8e-03 | 4.6 | 5.5 | 4.9e-08 | -0.71 | 0.06 | 0.86 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | FAM213A | 0.59 | 0.00 | enet | 3 | 0.00 | 4.6e-01 | -6.2 | -5.8 | 9.0e-09 | 0.61 | 0.12 | 0.33 | FALSE |
| 5 | GTEx | Thyroid | FAM213A | 0.11 | 0.05 | lasso | 8 | 0.06 | 1.4e-05 | 5.8 | 5.4 | 6.2e-08 | -0.71 | 0.36 | 0.57 | FALSE |
| 6 | GTEx | Whole Blood | TSPAN14 | 0.08 | 0.08 | enet | 12 | 0.07 | 7.6e-07 | -6.0 | 5.4 | 6.0e-08 | -0.65 | 0.41 | 0.57 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C10orf58 | 0.03 | 0.01 | blup | 65 | 0.01 | 2.9e-02 | 4.1 | 5.6 | 2.1e-08 | -0.68 | 0.01 | 0.78 | FALSE |
| 8 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DYDC2 | 0.11 | 0.02 | enet | 4 | 0.06 | 1.3e-03 | 4.6 | -6.3 | 2.3e-10 | 0.70 | 0.02 | 0.46 | TRUE |