Best TWAS P=1.73e-21 · Best GWAS P=1.86e-37 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HELLS | 0.04 | 0.04 | enet | 12 | 0.04 | 5.1e-06 | -7.72 | -8.4 | 4.5e-17 | -0.58 | 0.93 | 0.04 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NOC3L | 0.10 | 0.11 | lasso | 5 | 0.12 | 4.7e-14 | -5.03 | -6.9 | 4.5e-12 | -0.53 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | HELLS | 0.08 | 0.06 | enet | 30 | 0.04 | 7.0e-04 | -7.69 | -6.8 | 9.2e-12 | -0.26 | 0.90 | 0.00 | FALSE |
| 4 | GTEx | Adrenal Gland | NOC3L | 0.21 | 0.10 | lasso | 5 | 0.18 | 4.4e-07 | -0.11 | -5.9 | 2.8e-09 | -0.52 | 0.82 | 0.04 | TRUE |
| 5 | GTEx | Artery Aorta | CYP2C8 | 0.21 | 0.00 | lasso | 8 | 0.00 | 2.2e-01 | -3.83 | -6.3 | 2.2e-10 | -0.32 | 0.17 | 0.10 | FALSE |
| 6 | GTEx | Brain Cerebellum | HELLS | 0.26 | 0.20 | lasso | 9 | 0.19 | 2.8e-06 | -6.94 | -8.1 | 5.1e-16 | -0.48 | 0.95 | 0.01 | FALSE |
| 7 | GTEx | Brain Frontal Cortex BA9 | HELLS | 0.16 | 0.09 | enet | 20 | 0.15 | 1.0e-04 | -6.96 | -7.4 | 9.8e-14 | -0.34 | 0.54 | 0.05 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Male) | NOC3L | 0.40 | 0.03 | enet | 34 | 0.12 | 8.9e-04 | -7.33 | -6.2 | 7.7e-10 | -0.36 | 0.04 | 0.21 | TRUE |
| 9 | GTEx | Colon Sigmoid | NOC3L | 0.34 | 0.10 | lasso | 10 | 0.12 | 3.7e-05 | -0.11 | -5.5 | 3.3e-08 | -0.50 | 0.54 | 0.35 | FALSE |
| 10 | GTEx | Lung | NOC3L | 0.16 | 0.10 | enet | 36 | 0.10 | 2.9e-08 | -0.28 | -5.9 | 4.6e-09 | -0.56 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Muscle Skeletal | NOC3L | 0.09 | 0.05 | enet | 7 | 0.05 | 7.5e-06 | -5.25 | -8.9 | 3.6e-19 | -0.54 | 0.84 | 0.04 | TRUE |
| 12 | GTEx | Nerve Tibial | HELLS | 0.12 | 0.12 | enet | 17 | 0.10 | 1.6e-07 | -7.69 | -6.8 | 1.4e-11 | -0.30 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Nerve Tibial | PLCE1 | 0.35 | 0.11 | enet | 25 | 0.23 | 2.1e-16 | -0.99 | -5.4 | 6.8e-08 | -0.23 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Ovary | HELLS | 0.15 | 0.04 | lasso | 5 | 0.09 | 3.1e-03 | -7.84 | -7.5 | 5.8e-14 | -0.36 | 0.14 | 0.26 | TRUE |
| 15 | GTEx | Skin Sun Exposed Lower leg | HELLS | 0.05 | 0.02 | lasso | 3 | 0.00 | 1.2e-01 | -6.91 | -6.5 | 8.6e-11 | -0.38 | 0.42 | 0.04 | FALSE |
| 16 | GTEx | Testis | HELLS | 0.08 | 0.00 | enet | 27 | 0.00 | 3.1e-01 | -6.91 | -8.3 | 7.6e-17 | -0.44 | 0.12 | 0.23 | TRUE |
| 17 | GTEx | Testis | HHEX | 0.11 | 0.02 | enet | 8 | 0.00 | 4.2e-01 | 4.42 | 5.2 | 2.3e-07 | 0.00 | 0.03 | 0.44 | TRUE |
| 18 | GTEx | Testis | PIPSL | 0.14 | 0.00 | enet | 21 | 0.00 | 3.0e-01 | -0.91 | 5.7 | 1.5e-08 | 0.26 | 0.06 | 0.13 | FALSE |
| 19 | GTEx | Thyroid | HELLS | 0.07 | 0.00 | enet | 8 | 0.00 | 2.7e-01 | -7.79 | -8.5 | 2.3e-17 | -0.33 | 0.09 | 0.16 | FALSE |
| 20 | METSIM | Adipose | HELLS | 0.03 | 0.04 | lasso | 3 | 0.03 | 9.3e-05 | -7.69 | -7.7 | 9.8e-15 | -0.39 | 0.99 | 0.00 | FALSE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | HELLS | 0.02 | 0.01 | blup | 372 | 0.00 | 6.9e-02 | -6.94 | -7.2 | 8.8e-13 | -0.45 | 0.50 | 0.09 | FALSE |
| 22 | ROSMAP | Brain Pre-frontal Cortex | CYP2C8 | 0.09 | 0.02 | bslmm | 491 | 0.06 | 3.4e-08 | 2.01 | -5.8 | 8.4e-09 | -0.20 | 0.99 | 0.00 | TRUE |
| 23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HELLS | 0.04 | 0.01 | blup | 47 | 0.03 | 1.3e-06 | -7.74 | -9.5 | 3.1e-21 | -0.56 | 0.04 | 0.96 | TRUE |
| 24 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TBC1D12 | 0.04 | 0.01 | blup | 63 | 0.03 | 8.3e-03 | -6.90 | 8.0 | 1.3e-15 | 0.34 | 0.08 | 0.04 | FALSE |
| 25 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HELLS | 0.03 | 0.03 | blup | 47 | 0.03 | 1.7e-04 | -6.96 | -8.3 | 9.5e-17 | -0.45 | 0.40 | 0.50 | FALSE |
| 26 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOC3L | 0.05 | 0.01 | enet | 5 | 0.03 | 6.3e-04 | 11.48 | -8.7 | 2.3e-18 | -0.76 | 0.01 | 0.97 | FALSE |
| 27 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HELLS | 0.03 | 0.03 | lasso | 3 | 0.02 | 5.7e-03 | -6.91 | -6.4 | 1.6e-10 | -0.38 | 0.23 | 0.56 | TRUE |
| 28 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOC3L | 0.08 | 0.06 | lasso | 2 | 0.04 | 5.8e-03 | -7.21 | -7.2 | 5.7e-13 | -0.51 | 0.04 | 0.05 | FALSE |
| 29 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HELLS | 0.03 | 0.02 | blup | 47 | 0.03 | 2.1e-04 | -6.90 | -8.7 | 3.0e-18 | -0.49 | 0.07 | 0.87 | FALSE |
| 30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBC1D12 | 0.04 | 0.04 | blup | 63 | 0.03 | 3.9e-04 | -7.62 | -9.2 | 4.2e-20 | -0.43 | 0.24 | 0.50 | FALSE |
| 31 | The Cancer Genome Atlas | Thyroid Carcinoma | HELLS | 0.05 | 0.02 | blup | 47 | 0.03 | 9.6e-04 | -6.96 | -9.5 | 1.7e-21 | -0.54 | 0.07 | 0.82 | TRUE |