[Hub]/) : Traits : Systolic Blood Pressure :

chr10:93,754,543-97,524,313

Best TWAS P=1.73e-21 · Best GWAS P=1.86e-37 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HELLS 0.04 0.04 enet 12 0.04 5.1e-06 -7.72 -8.4 4.5e-17 -0.58 0.93 0.04 FALSE
2 CommonMind Brain Pre-frontal Cortex NOC3L 0.10 0.11 lasso 5 0.12 4.7e-14 -5.03 -6.9 4.5e-12 -0.53 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous HELLS 0.08 0.06 enet 30 0.04 7.0e-04 -7.69 -6.8 9.2e-12 -0.26 0.90 0.00 FALSE
4 GTEx Adrenal Gland NOC3L 0.21 0.10 lasso 5 0.18 4.4e-07 -0.11 -5.9 2.8e-09 -0.52 0.82 0.04 TRUE
5 GTEx Artery Aorta CYP2C8 0.21 0.00 lasso 8 0.00 2.2e-01 -3.83 -6.3 2.2e-10 -0.32 0.17 0.10 FALSE
6 GTEx Brain Cerebellum HELLS 0.26 0.20 lasso 9 0.19 2.8e-06 -6.94 -8.1 5.1e-16 -0.48 0.95 0.01 FALSE
7 GTEx Brain Frontal Cortex BA9 HELLS 0.16 0.09 enet 20 0.15 1.0e-04 -6.96 -7.4 9.8e-14 -0.34 0.54 0.05 FALSE
8 GTEx Breast Mammary Tissue (Male) NOC3L 0.40 0.03 enet 34 0.12 8.9e-04 -7.33 -6.2 7.7e-10 -0.36 0.04 0.21 TRUE
9 GTEx Colon Sigmoid NOC3L 0.34 0.10 lasso 10 0.12 3.7e-05 -0.11 -5.5 3.3e-08 -0.50 0.54 0.35 FALSE
10 GTEx Lung NOC3L 0.16 0.10 enet 36 0.10 2.9e-08 -0.28 -5.9 4.6e-09 -0.56 1.00 0.00 FALSE
11 GTEx Muscle Skeletal NOC3L 0.09 0.05 enet 7 0.05 7.5e-06 -5.25 -8.9 3.6e-19 -0.54 0.84 0.04 TRUE
12 GTEx Nerve Tibial HELLS 0.12 0.12 enet 17 0.10 1.6e-07 -7.69 -6.8 1.4e-11 -0.30 1.00 0.00 FALSE
13 GTEx Nerve Tibial PLCE1 0.35 0.11 enet 25 0.23 2.1e-16 -0.99 -5.4 6.8e-08 -0.23 1.00 0.00 FALSE
14 GTEx Ovary HELLS 0.15 0.04 lasso 5 0.09 3.1e-03 -7.84 -7.5 5.8e-14 -0.36 0.14 0.26 TRUE
15 GTEx Skin Sun Exposed Lower leg HELLS 0.05 0.02 lasso 3 0.00 1.2e-01 -6.91 -6.5 8.6e-11 -0.38 0.42 0.04 FALSE
16 GTEx Testis HELLS 0.08 0.00 enet 27 0.00 3.1e-01 -6.91 -8.3 7.6e-17 -0.44 0.12 0.23 TRUE
17 GTEx Testis HHEX 0.11 0.02 enet 8 0.00 4.2e-01 4.42 5.2 2.3e-07 0.00 0.03 0.44 TRUE
18 GTEx Testis PIPSL 0.14 0.00 enet 21 0.00 3.0e-01 -0.91 5.7 1.5e-08 0.26 0.06 0.13 FALSE
19 GTEx Thyroid HELLS 0.07 0.00 enet 8 0.00 2.7e-01 -7.79 -8.5 2.3e-17 -0.33 0.09 0.16 FALSE
20 METSIM Adipose HELLS 0.03 0.04 lasso 3 0.03 9.3e-05 -7.69 -7.7 9.8e-15 -0.39 0.99 0.00 FALSE
21 ROSMAP Brain Pre-frontal Cortex HELLS 0.02 0.01 blup 372 0.00 6.9e-02 -6.94 -7.2 8.8e-13 -0.45 0.50 0.09 FALSE
22 ROSMAP Brain Pre-frontal Cortex CYP2C8 0.09 0.02 bslmm 491 0.06 3.4e-08 2.01 -5.8 8.4e-09 -0.20 0.99 0.00 TRUE
23 The Cancer Genome Atlas Breast Invasive Carcinoma HELLS 0.04 0.01 blup 47 0.03 1.3e-06 -7.74 -9.5 3.1e-21 -0.56 0.04 0.96 TRUE
24 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma TBC1D12 0.04 0.01 blup 63 0.03 8.3e-03 -6.90 8.0 1.3e-15 0.34 0.08 0.04 FALSE
25 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HELLS 0.03 0.03 blup 47 0.03 1.7e-04 -6.96 -8.3 9.5e-17 -0.45 0.40 0.50 FALSE
26 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NOC3L 0.05 0.01 enet 5 0.03 6.3e-04 11.48 -8.7 2.3e-18 -0.76 0.01 0.97 FALSE
27 The Cancer Genome Atlas Brain Lower Grade Glioma HELLS 0.03 0.03 lasso 3 0.02 5.7e-03 -6.91 -6.4 1.6e-10 -0.38 0.23 0.56 TRUE
28 The Cancer Genome Atlas Pancreatic Adenocarcinoma NOC3L 0.08 0.06 lasso 2 0.04 5.8e-03 -7.21 -7.2 5.7e-13 -0.51 0.04 0.05 FALSE
29 The Cancer Genome Atlas Prostate Adenocarcinoma HELLS 0.03 0.02 blup 47 0.03 2.1e-04 -6.90 -8.7 3.0e-18 -0.49 0.07 0.87 FALSE
30 The Cancer Genome Atlas Prostate Adenocarcinoma TBC1D12 0.04 0.04 blup 63 0.03 3.9e-04 -7.62 -9.2 4.2e-20 -0.43 0.24 0.50 FALSE
31 The Cancer Genome Atlas Thyroid Carcinoma HELLS 0.05 0.02 blup 47 0.03 9.6e-04 -6.96 -9.5 1.7e-21 -0.54 0.07 0.82 TRUE