Hub : Genes

NAA40

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.073 0.0350 8.9e-03 0.015 NA 0.001 NA 0.004 0.03300 NA 2.8e-01 NA 1.6e-01
2 GTEx Thyroid 0.097 0.0450 4.9e-03 -0.003 NA 0.008 NA -0.003 0.67000 NA 7.5e-02 NA 7.8e-01
3 METSIM Adipose 0.084 0.0266 6.1e-08 0.024 0.051 0.041 0.052 0.041 0.00013 3.5e-08 8.1e-07 2.8e-08 8.0e-07
4 TCGA Thyroid Carcinoma 0.038 0.0260 2.0e-03 0.032 0.024 0.026 NA 0.029 0.00037 1.9e-03 1.3e-03 NA 7.4e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 3.2 5.1 11.0 -0.1 2.6 1.6 3.3
Bipolar Disorder or Schizophrenia 5.6 13.7 23.8 1.7 4.3 3.1 4.9
Depressed Affect (Nagel 2018) 0.6 1.2 3.3 -0.9 -0.1 -1.8 -0.7
Depression (Nagel 2018) 0.3 0.5 1.8 0.2 -1.4 0.0 0.4
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.2 -1.1 -0.9 -0.3 0.6
Neuroticism (Nagel 2018) 0.9 2.1 5.4 0.2 -1.1 -2.3 -1.2
Schizophrenia (2018) 4.4 9.1 13.1 2.4 3.4 2.5 3.6
Schizophrenia vs Biploar Disorder 1.3 1.7 5.2 2.3 -0.6 1.1 0.2
Worry (Nagel 2018) 1.1 2.2 4.7 1.4 -2.2 -0.7 -1.3
Alzheimer’s Disease (in mother) 0.4 0.5 1.4 0.1 0.5 0.5 1.2
Alzheimer’s Disease (in father) 0.2 0.2 0.5 -0.7 -0.2 0.1 -0.7
Alzheimer’s Disease (including proxy) 0.8 1.1 2.7 -0.7 0.8 0.9 1.6
Crohns Disease (2017) 3.6 8.0 15.3 -2.7 3.9 -0.5 3.0
Irritable Bowel Disease (IBD) 2.4 5.8 12.0 -2.7 3.5 -0.5 1.9
Ulcerative Colitis (UC) 0.9 1.7 3.6 -1.7 1.9 -0.4 0.0
Major Depression (MDD) 2.8 3.4 7.4 0.3 2.1 1.4 2.7
Reaction Time 0.6 1.2 2.4 -1.6 -0.9 0.4 1.1
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.9 -0.9 -0.5 -0.1 0.9
Breast Cancer 1.9 4.5 6.2 -1.8 2.5 1.8 2.3
Ovarian Cancer 0.3 0.4 1.0 0.6 1.0 -0.5 0.3
Prostate Cancer 1.5 2.2 3.3 -1.8 -1.4 -1.8 -0.6
Age at First Birth 0.5 0.8 1.9 -0.2 -1.4 -0.2 -1.1
Bipolar Disorder (2011) 0.7 0.6 2.2 0.2 0.0 0.5 1.5
Body Mass Index (BMI) (2010) 0.5 0.7 1.7 1.3 0.6 -0.0 -0.8
Coronary Artery Disease (CAD) 1.6 2.0 3.9 1.4 2.0 0.8 1.2
Crohns Disease (2012) 2.2 3.6 8.6 -1.7 2.9 -1.3 1.1
Mean Putamen Volume 1.1 1.3 3.8 1.9 -1.1 -0.2 0.1
Fasting Glucose 0.7 0.8 2.1 0.9 -1.4 -0.6 -0.1
HbA1C 1.2 1.3 2.8 -1.7 1.0 1.1 0.5
HDL Cholesterol 0.5 0.8 2.3 0.9 1.5 -0.2 0.2
LDL Cholesterol 1.0 1.5 3.3 -1.3 1.8 -0.3 1.0
Lupus 2.3 3.5 6.7 -2.6 -1.6 -2.2 -0.2
Neuroticism (2016) 0.1 0.2 0.5 0.4 0.3 -0.7 -0.0
Primary Biliary Cirrhosis 2.1 2.9 8.1 -0.0 1.9 -2.8 -0.0
Rheumatoid Arthritis 1.4 1.9 4.6 2.1 -0.5 -1.6 -0.3
Schizophrenia (2014) 4.1 9.0 12.7 2.6 3.3 2.4 3.6
Triglycerides 0.5 0.8 1.8 -0.2 -1.4 -0.5 -1.0
Type 2 Diabetes (T2D) (2012) 1.3 1.5 3.8 -1.9 -0.7 -0.7 -1.0
Ulcerative Colitis 1.0 1.5 2.4 -1.3 1.3 -1.6 -0.5
Blood Eosinophil Count 1.1 8.2 29.4 -0.6 0.6 5.4 1.7
Blood Platelet Count 1.0 11.4 17.4 2.9 4.2 4.0 1.9
Blood Red Count 0.8 8.2 16.7 -0.3 4.0 4.1 -0.1
Blood White Count 0.7 5.3 13.8 -0.4 3.7 1.0 2.5
Heel T-Score 0.8 6.0 13.0 -1.0 1.0 3.6 3.0
BMI 0.5 3.0 7.3 2.7 0.2 1.6 -1.4
Height 0.4 7.0 17.1 0.7 -3.1 -0.8 -4.1
Waist Hip Ratio (WHR) 1.7 7.6 15.0 -3.9 -2.7 -2.7 0.9
Systolic Blood Pressure 3.6 18.1 26.5 -4.5 -2.5 -5.2 -4.4
Smoking Status 0.8 1.8 2.7 1.4 1.6 -1.6 0.3
Allergy or Eczema 1.2 3.1 7.6 -1.8 1.3 2.7 0.6
Cardiovascular Disease 0.7 2.5 4.0 -1.3 1.8 -2.0 -1.0
Hypothyroidism (self reported) 0.8 1.8 6.9 -0.4 -0.0 -2.6 0.4
Respiratory disease 0.7 1.5 4.3 -0.4 0.3 2.1 1.1
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.7 -1.3 0.3 -0.5 -0.2
Lung FEV1/FVC ratio 1.2 5.9 11.4 0.8 2.1 2.7 3.4
Lung FVC 0.9 4.7 11.9 1.4 1.5 1.6 3.5
Neuroticism 1.2 2.8 5.7 0.5 -1.7 -2.4 -1.5
Chronotype (morning person) 0.1 0.3 0.5 0.6 -0.7 0.2 0.5
Hair Pigment 0.1 2.3 4.3 -1.4 0.0 -1.7 -2.1
Tanning 0.1 1.1 3.0 0.8 0.1 1.7 1.0
Hand grip strength (left) 0.7 1.9 2.9 -0.1 1.6 1.7 1.5
Number of treatments/medications taken 0.5 0.8 2.5 -0.9 0.1 -1.6 -0.1
Average weekly spirits intake 0.8 1.0 2.9 0.0 -1.7 0.5 0.9
Sensitivity / hurt feelings 1.8 3.0 6.8 -1.7 -1.0 -2.6 1.3
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.0 -0.2 -0.3 0.8 1.0
Hearing difficulty/problems: Yes 0.4 0.6 1.0 0.3 0.8 -0.8 -1.0
Relative age of first facial hair 0.2 0.4 0.8 -0.9 -0.1 -0.7 0.3
Other serious medical condition/disability diagnosed by doctor 2.4 3.1 7.1 -2.1 0.6 0.8 2.7
Ever used hormone-replacement therapy (HRT) 1.6 2.1 7.4 -0.9 2.7 0.1 0.3
Ever had hysterectomy (womb removed) 0.6 0.6 2.0 1.4 -0.4 0.5 -0.4
Systolic blood pressure, automated reading 3.0 8.6 17.1 -4.1 -0.3 -2.7 -3.1
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 2.0 -1.4 -1.2 1.1 1.0
Angina 0.2 0.3 0.8 -0.9 0.2 0.1 -0.6
Medication for hormone replacement therapy 1.5 1.7 4.9 0.8 2.2 0.4 1.0
Vitamin and mineral supplements 2.1 2.8 8.1 -0.4 -2.9 1.2 -1.2
Supplements: Zinc 0.8 0.9 1.6 -1.3 0.4 -0.8 1.1
Medication: Co-codamol 0.6 0.7 1.5 0.8 0.2 1.2 0.7
Medication: Metformin 0.5 0.7 2.1 -1.5 -0.4 -0.4 0.5
Diabetes (father) 0.7 0.9 1.4 -1.1 -0.3 0.8 -1.2
Diabetes (mother) 1.9 2.4 4.3 -0.2 -1.5 2.1 1.7
Severe depression (siblings) 0.4 0.5 0.8 0.7 -0.8 0.9 0.1
Pack years adult smoking proportion 0.5 0.8 1.3 0.8 0.7 1.1 0.8
Impedance of leg (right) 0.3 1.5 4.1 -0.3 -0.7 -2.0 -1.1
Leg fat-free mass (left) 0.5 2.7 5.5 1.7 -0.8 2.4 -1.4
Trunk fat percentage 0.3 1.3 4.2 0.6 0.7 2.0 -0.2
Hand grip strength (right) 1.0 2.8 5.0 -0.5 1.4 2.2 2.0
Townsend deprivation index at recruitment 0.7 0.9 1.6 0.9 0.6 -1.0 -1.2
Current tobacco smoking 0.6 1.0 2.5 1.6 1.2 -0.1 0.0
Average weekly fortified wine intake 1.9 2.3 4.0 0.9 -1.5 2.0 1.4
Maternal smoking around birth 2.2 3.2 5.7 2.4 0.8 -2.1 -1.3
Fed-up feelings 1.5 2.8 5.1 1.0 -1.5 -2.3 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.2 0.2 -1.2 -1.5 -0.8
Relative age voice broke 0.5 0.8 1.8 0.9 -0.7 -1.4 -0.1
Taking other prescription medications 0.8 1.2 4.0 -0.0 0.5 -2.0 0.5
Age when periods started (menarche) 0.2 0.5 1.5 1.2 -0.6 0.2 0.2
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.7 1.3 0.3 -0.2 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 6.9 1.6 -0.7 2.6 1.6
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.4 -1.2 -0.2 -0.8 -0.2
Qualifications: CSEs or equivalent 0.3 0.4 0.8 -0.9 0.6 0.6 0.3
Serious illness, injury or assault to yourself 0.1 0.2 0.4 -0.1 -0.4 -0.1 -0.7
High blood pressure 1.6 4.3 9.7 -1.3 0.7 -3.1 -2.3
Hayfever, allergic rhinitis or eczema 0.9 2.0 4.9 -1.5 0.9 2.2 0.0
Multivitamins +/- minerals 1.9 2.4 6.0 0.1 2.4 -1.0 1.6
Stomach or abdominal pain in last month 0.7 0.9 1.8 0.4 -0.1 1.3 1.3
Supplements: Glucosamine 0.4 0.5 1.2 1.1 -0.6 -0.4 -0.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 0.7 -0.8 -0.8 0.1 -0.6
Medication: Atenolol 1.0 1.3 4.1 -2.0 0.9 0.4 0.4
Medication: Levothyroxine sodium 1.2 2.1 6.6 0.8 -0.0 -2.6 -1.0
Sitting height 0.5 3.4 5.7 1.4 -1.8 1.7 -2.4
Chronic bronchitis/emphysema (father) 0.9 1.0 2.6 -1.2 0.1 0.2 1.6
High blood pressure (mother) 1.3 1.8 2.9 1.7 1.7 1.2 -0.3
Body mass index (BMI) 0.5 2.2 5.7 1.2 1.1 2.4 0.5
Impedance of leg (left) 0.2 1.1 3.6 -0.6 -0.3 -1.9 -0.4
Leg predicted mass (left) 0.5 2.9 5.8 1.7 -0.8 2.4 -1.4
Trunk fat mass 0.4 1.7 5.1 1.1 0.2 2.3 -0.8
Waist circumference 0.2 0.8 3.1 0.1 -0.5 1.8 -0.2
Number of incorrect matches in round 0.3 0.5 1.3 -0.8 0.2 0.3 1.1
Past tobacco smoking 1.4 2.6 8.3 -0.1 -2.9 1.3 -0.5
Alcohol usually taken with meals 1.1 1.8 4.3 -0.7 -0.8 1.3 2.1
Nervous feelings 0.4 0.8 1.4 0.7 -0.8 -0.9 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 1.0 -0.0 -1.0 -0.6 0.2
Hearing difficulty/problems with background noise 1.0 1.6 2.4 -0.0 1.4 1.4 1.6
Hair/balding pattern: Pattern 2 0.1 0.2 0.3 0.2 0.6 0.3 0.5
Had menopause 2.9 3.7 5.8 -0.7 2.3 2.4 1.8
Had other major operations 1.3 1.6 4.7 -0.7 -0.9 -2.2 -0.6
Forced vital capacity (FVC) 0.7 2.6 5.2 1.0 -0.3 2.3 2.0
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.9 12.7 1.0 -0.7 3.6 2.3
Ever unenthusiastic/disinterested for a whole week 1.4 1.8 3.0 -1.7 0.6 -0.9 1.7
Qualifications: None of the above 0.5 1.0 2.6 -0.4 -0.5 -1.6 -1.0
Financial difficulties in last 2 years 1.2 1.7 2.1 -1.5 1.3 -1.3 -1.0
Mouth/teeth dental problems 0.3 0.5 1.4 -0.4 -0.0 1.2 0.6
Heart attack 0.7 0.8 2.6 -1.6 -0.2 -0.3 0.8
Allergy 0.7 1.6 5.7 0.9 0.1 -2.4 -0.2
Pain all over the body in last month 0.4 0.4 1.0 -0.4 0.7 0.3 1.0
Diabetes (self-reported) 0.2 0.4 1.1 -1.0 -0.4 0.2 -0.4
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.8 -0.9 0.4 0.7 0.3
Medication: Ramipril 1.3 1.7 2.4 -1.2 1.6 -1.3 -1.2
Medication: Simvastatin 2.2 3.2 6.2 -2.5 2.3 -0.2 1.2
Fluid intelligence score 0.4 0.8 1.5 0.2 -1.0 0.7 1.2
Illnesses of siblings 0.9 1.3 4.5 -0.2 -2.1 -0.8 -0.3
Neuroticism score 0.5 1.0 2.5 1.1 -0.7 -1.6 -0.2
Weight 0.5 2.6 6.8 1.7 -0.2 2.6 -0.9
Impedance of arm (right) 0.1 0.4 1.0 -1.0 0.4 -0.8 -0.1
Arm fat percentage (right) 0.5 2.0 5.7 1.0 1.1 2.4 0.2
Trunk fat-free mass 0.6 3.4 5.0 2.0 -1.5 1.5 -2.2
Hip circumference 1.0 4.3 10.8 2.4 0.3 3.3 -0.8
Time employed in main current job 1.8 2.0 4.0 1.2 -2.0 -0.9 -1.5
Alcohol intake versus 10 years previously 0.9 1.3 3.0 -1.7 -0.6 -1.4 -0.1
Father’s age at death 1.1 1.4 2.6 0.3 1.1 1.6 1.4
Worrier / anxious feelings 0.3 0.6 2.3 0.4 -0.3 -0.1 1.5
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.0 4.2 -0.0 2.0 0.9 1.8
Falls in the last year 1.4 1.8 6.5 2.5 0.5 0.3 -0.7
Hair/balding pattern: Pattern 3 0.7 1.0 2.9 1.7 -0.8 0.4 -0.7
Number of live births 1.2 1.7 3.9 0.2 2.0 0.1 1.7
Forced expiratory volume in 1-second (FEV1) 1.1 3.8 7.4 0.9 -0.1 2.7 2.7
Pulse rate 1.1 1.8 3.4 1.8 1.9 0.5 0.7
Happiness 0.3 0.3 0.7 0.7 0.1 0.8 0.3
Noisy workplace 0.7 0.9 2.9 -0.2 1.7 -0.4 -0.6
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.8 0.3 -1.3 0.8 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.7 -0.8 -0.7 -0.1 -0.7
Mouth/teeth dental problems: Dentures 0.3 0.6 0.9 0.3 0.9 -1.0 -0.7
Asthma 0.6 1.1 2.2 -1.0 0.3 1.5 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 1.9 0.5 -1.2 -1.4 -1.0
Medication: Cholesterol lowering 0.7 1.1 3.2 -1.8 0.8 -0.2 0.7
Depression (self-reported) 0.8 0.9 2.5 0.0 1.0 0.3 1.6
Medication: Lansoprazole 2.1 2.4 3.8 2.0 1.2 1.3 1.6
Prospective memory result 1.1 1.4 2.9 0.3 1.5 -0.3 1.7
Lung cancer (father) 0.4 0.5 1.8 -1.3 -0.4 0.3 0.2
Illnesses of mother 1.3 1.6 2.4 -1.6 -1.1 -1.2 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 8.0 1.6 0.0 2.8 2.2
Pulse wave Arterial Stiffness index 1.1 1.2 4.9 -0.2 0.1 -2.2 -0.0
Impedance of arm (left) 0.1 0.5 1.3 -1.2 -0.3 -0.5 -0.3
Arm fat mass (right) 0.6 2.6 7.2 1.5 0.9 2.7 -0.1
Trunk predicted mass 0.6 3.3 4.9 2.0 -1.5 1.5 -2.2
Standing height 0.5 5.1 9.1 1.4 -3.0 0.8 -3.0
Length of working week for main job 0.5 0.6 0.8 0.8 -0.9 0.5 -0.8
Exposure to tobacco smoke at home 0.9 1.0 2.0 -0.1 -1.1 -0.9 -1.4
Breastfed as a baby 1.9 2.3 3.7 -1.9 1.3 1.2 1.6
Tense / ‘highly strung’ 0.9 1.4 4.3 2.1 -0.0 -0.2 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.3 9.2 -0.3 1.9 0.1 3.0
Hair/balding pattern: Pattern 4 0.2 0.5 1.3 -1.1 0.4 -0.8 -0.2
Birth weight of first child 2.7 4.9 13.5 -2.0 1.3 0.4 3.7
Peak expiratory flow (PEF) 0.8 1.9 5.4 -0.0 0.7 1.4 2.3
Pulse wave reflection index 2.9 3.6 6.2 0.1 -1.7 -2.3 -2.5
Ever highly irritable/argumentative for 2 days 2.5 3.0 8.0 -1.6 2.8 -1.2 0.4
Loud music exposure frequency 0.3 0.4 1.0 0.4 0.1 0.5 -1.0
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 3.0 -1.7 0.4 1.0 1.4
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 0.9 -0.2 -0.6 1.0 -0.3
Blood clot in the leg (DVT) 1.4 1.8 3.2 0.7 -1.1 -1.5 -1.8
Medication: Paracetamol 0.5 0.8 1.8 0.8 -0.0 -1.3 -0.9
Headache pain in last month 0.3 0.5 1.1 0.9 -1.1 0.4 0.1
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.2 1.0 -1.1 1.0 0.6
Glaucoma (self-reported) 2.3 2.7 3.9 -0.8 -2.0 -1.5 -2.0
Gout (self-reported) 3.2 4.4 7.3 -1.4 2.7 1.0 2.7
Hypothyroidism/myxoedema (self-reported) 0.6 1.3 4.6 -0.4 0.4 -2.2 -0.2
Medication: Amlodipine 1.0 1.4 2.3 -1.5 0.7 -1.4 -1.0
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.1 0.0 -0.1 1.1 1.0
Birth weight 2.1 4.6 12.7 -1.9 0.6 1.4 3.6
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.7 -0.8 0.9 -0.1 1.6
High blood pressure (siblings) 0.8 1.1 3.2 0.2 0.7 -0.9 -1.8
Forced vital capacity (FVC), Best measure 0.6 2.1 4.1 1.2 -0.5 2.0 1.6
Body fat percentage 0.3 1.3 3.8 0.7 0.9 2.0 -0.2
Leg fat percentage (right) 0.3 1.0 2.2 0.9 1.0 1.5 -0.1
Arm fat-free mass (right) 0.5 2.7 3.2 1.8 -1.4 1.8 -1.6
Exposure to tobacco smoke outside home 0.9 1.2 2.9 1.7 0.3 -0.9 -1.0
Comparative body size at age 10 0.1 0.3 0.8 0.6 -0.9 -0.3 -0.3
Number of full brothers 0.8 1.0 2.9 -0.3 0.8 0.5 1.7
Worry too long after embarrassment 0.6 1.0 3.3 1.8 0.0 0.1 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.8 0.1 -0.0 0.9 1.7
Wheeze or whistling in the chest in last year 0.2 0.3 0.8 -0.5 0.9 0.1 0.0
Number of children fathered 1.8 2.0 3.6 -1.2 1.7 0.3 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.9 0.9 0.2 1.4 0.4
Age at first live birth 0.9 1.6 2.7 1.6 -1.4 -0.1 -1.3
Pulse wave peak to peak time 1.0 1.2 4.6 0.3 -0.4 2.1 -0.3
Health satisfaction 0.8 1.1 2.4 1.5 0.9 0.1 1.0
Shortness of breath walking on level ground 0.7 0.8 1.9 -0.0 1.4 0.8 0.9
Qualifications: College or University degree 0.9 2.8 5.0 0.8 -0.9 2.2 2.1
Eye problems/disorders: None of the above 0.8 0.9 2.1 1.4 0.9 -0.7 -0.3
Mouth/teeth dental problems: Loose teeth 1.0 1.2 4.2 -0.6 0.1 -0.6 -2.0
Emphysema/chronic bronchitis 0.1 0.1 0.3 0.5 -0.3 -0.3 -0.1
Medication for pain relief, constipation, heartburn 0.3 0.5 1.1 -0.3 1.0 1.0 0.0
Neck or shoulder pain in last month 0.4 0.5 1.7 -1.3 0.0 0.5 0.5
Medication: Blood pressure 1.2 2.2 3.6 -1.9 0.4 -1.7 -1.4
Angina (self-reported) 0.3 0.4 1.6 -1.3 0.0 0.0 -0.4
Migraine (self-reported) 1.2 1.5 4.2 0.4 -2.0 0.8 1.0
Medication: Ibuprofen 0.6 0.8 1.4 0.3 -1.2 -1.0 -0.8
Medication: Allopurinol 0.9 1.2 3.3 -0.4 1.1 0.3 1.8
Medication: Omeprazole 0.3 0.3 0.9 -0.2 -0.3 0.9 0.5
Medication: Seretide 50 evohaler 0.7 0.8 1.6 1.3 0.6 1.0 0.6
Mean time to correctly identify matches 0.7 1.3 3.0 -1.7 0.3 0.4 1.5
Heart disease (mother) 2.5 3.1 6.2 1.3 2.5 1.9 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.3 -0.2 0.6 0.3 -0.1
Whole body fat mass 0.4 1.8 5.0 1.4 0.2 2.2 -0.7
Leg fat mass (right) 0.4 1.6 3.5 1.4 0.5 1.9 -0.8
Arm predicted mass (right) 0.5 2.7 3.3 1.8 -1.2 1.7 -1.8
Pulse rate, automated reading 0.4 1.2 1.6 -0.1 1.2 1.3 1.2
Alcohol intake frequency. 0.6 1.5 4.3 -2.1 1.0 -0.7 0.4
Comparative height size at age 10 0.1 0.6 1.8 0.1 -0.4 0.6 -1.4
Number of full sisters 1.3 1.6 2.9 0.7 1.7 0.8 1.6
Suffer from ‘nerves’ 0.7 1.1 3.0 0.4 -1.7 -1.0 -0.7
Overall health rating 0.3 0.7 1.2 1.1 -0.1 -0.9 -1.0
Chest pain or discomfort 0.6 0.9 2.2 -0.3 -0.0 -1.5 -1.2
Had major operations 0.8 0.9 1.5 -0.5 1.2 0.7 1.2
Age at last live birth 0.4 0.6 1.0 0.7 -0.5 -0.7 -1.0
Family relationship satisfaction 1.1 1.4 3.2 1.8 0.9 0.6 1.0
Leg pain on walking 0.5 0.6 1.8 0.2 -0.4 1.4 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 6.4 -0.5 2.5 0.4 1.5
Commuting to job workplace: Car/motor vehicle 0.5 0.6 2.4 0.1 -0.2 0.1 1.5
Illness, injury, bereavement, stress in last 2 years 2.8 3.4 7.5 0.5 0.5 2.4 2.7
Medication: Aspirin 1.2 1.5 3.4 -1.8 0.9 -0.2 1.4
Supplements: Vitamin C 0.5 0.5 1.3 -0.5 1.1 -0.1 0.8
Knee pain experienced in last month 1.3 2.1 4.3 0.3 -2.1 -1.4 -1.4
Hypertension (Self-reported) 1.9 5.2 12.2 -1.3 0.7 -3.5 -2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.7 -0.3 0.1 -0.8 0.1
Illnesses of father: Heart disease 1.1 1.5 3.0 1.7 1.3 0.3 1.1
Illnesses of siblings: Diabetes 2.1 2.6 6.0 -0.1 1.4 1.6 2.5
Smoking status: Previous 1.1 1.6 4.9 0.3 2.2 -1.0 0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.2 3.4 1.5 -1.8 1.7 0.6
Whole body fat-free mass 0.6 3.2 4.1 2.0 -1.2 2.0 -1.9
Leg fat-free mass (right) 0.5 2.5 6.4 1.5 -0.7 2.5 -0.9
Arm fat percentage (left) 0.5 1.8 6.2 0.8 0.6 2.5 0.1
Average weekly red wine intake 0.7 1.0 1.4 1.2 -0.2 1.1 1.1
Handedness (chirality/laterality): Left-handed 1.7 2.1 3.3 -1.2 -1.1 -1.6 -1.8
Mood swings 0.8 1.4 3.8 0.6 1.2 -1.9 -0.4
Loneliness, isolation 1.2 1.6 3.2 0.3 -1.8 -1.3 -1.2
Long-standing illness, disability or infirmity 0.2 0.4 1.0 0.3 -0.4 -1.0 -0.5
Ever had bowel cancer screening 0.1 0.1 0.2 0.5 0.2 -0.2 -0.0
Diabetes diagnosed by doctor 0.3 0.5 1.5 -1.2 0.3 -0.3 0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.2 0.4 -1.0 -1.0 -1.5
Friendships satisfaction 0.6 0.7 2.1 1.5 -0.1 0.8 0.5
Qualifications: nursing, teaching 0.2 0.4 1.0 -0.6 -0.0 1.0 -0.3
Commuting to job workplace: Walk 1.8 1.9 7.1 0.3 2.7 0.5 0.4
Eye problems/disorders: Cataract 1.2 1.4 2.8 -1.6 0.5 0.2 1.7
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 3.5 -1.6 -0.1 -0.1 1.9
Medication for cholesterol 1.7 2.5 6.4 1.5 -2.5 1.2 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.1 0.9 0.6 0.9 1.5
Back pain experienced in last month 1.5 2.2 3.2 1.6 -0.8 -1.6 -1.8
Mineral and other dietary supplements 0.3 0.4 0.8 0.9 0.4 0.9 0.1
Breast cancer (self-reported) 0.2 0.3 0.7 0.9 0.5 -0.1 0.2
Asthma (self-reported) 0.4 0.8 2.0 -0.8 -0.2 1.4 0.8
Osteoporosis (self-reported) 2.0 2.4 9.1 -0.2 0.6 -3.0 0.4
Osteoarthritis (self-reported) 0.4 0.6 1.3 1.2 -0.3 0.4 -0.8
Medication: Aspirin 0.8 1.0 2.4 -1.6 0.7 -0.4 1.1
Medication: Gliclazide 0.5 0.6 1.6 1.2 -0.4 0.9 0.0
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 0.1 -0.4 0.3 -0.2
Smoking status: Current 0.5 0.8 1.6 1.3 1.1 -0.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.5 8.6 1.0 0.2 2.1 2.9
Whole body water mass 0.5 2.9 3.6 1.8 -1.1 1.9 -1.8
Leg predicted mass (right) 0.5 2.6 6.3 1.6 -0.8 2.5 -0.9
Arm fat mass (left) 0.5 2.2 7.2 1.2 0.4 2.7 -0.2
Number of self-reported non-cancer illnesses 1.0 1.7 4.2 -2.0 0.2 -1.6 0.2
Average weekly champagne plus white wine intake 0.2 0.2 0.5 0.1 -0.4 -0.7 -0.4
Miserableness 0.9 1.5 2.7 -1.6 0.9 -1.4 -0.7
Guilty feelings 0.4 0.6 1.2 0.1 0.7 -0.9 1.1
Wears glasses or contact lenses 1.3 1.5 2.6 -1.2 1.4 -0.0 1.6
Ever taken oral contraceptive pill 0.5 0.6 1.0 -0.3 0.7 1.0 0.9
Hearing aid user 1.2 1.3 2.5 -1.1 -0.5 -1.6 -1.2
Mother’s age at death 0.2 0.2 0.7 -0.9 -0.1 -0.0 0.4
Financial situation satisfaction 0.7 0.9 3.0 -0.5 -0.5 -0.2 -1.7
Tinnitus: Yes, now most or all of the time 1.8 2.2 3.2 1.6 1.8 1.3 1.1
Commuting to job workplace: Public transport 0.6 0.7 1.8 0.2 1.4 0.7 -0.8
Eye problems/disorders: Glaucoma 1.7 2.0 4.5 -0.3 -1.5 -1.1 -2.1
Medication: Blood pressure 1.2 2.2 4.3 -0.7 0.1 -2.0 -2.1
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.5 -0.7 0.3 0.3 -0.7
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.6 -1.3 -0.7 -0.4 -0.1
High cholesterol (Self-reported) 2.4 4.2 11.1 -1.8 3.3 0.1 1.7
Medication: Bendroflumethiazide 1.6 2.5 7.6 0.1 0.5 -2.8 -1.4
Medication: Paracetamol 0.6 0.9 1.6 1.1 -0.7 -0.6 -1.2
Medication: Lisinopril 0.5 0.7 1.2 1.1 -0.6 0.9 0.4
Medication: Atorvastatin 1.5 1.9 4.1 -1.9 2.0 -0.2 0.1
Illnesses of father: High blood pressure 1.1 1.3 2.0 -0.8 -1.4 -1.4 -0.9
Alcohol drinker status: Never 3.9 4.6 12.5 0.7 -1.9 -1.5 -3.5
Ever smoked 1.0 1.8 5.4 0.4 2.3 -1.3 0.1
Basal metabolic rate 0.6 3.1 4.5 1.9 -1.1 2.1 -1.8
Leg fat percentage (left) 0.3 1.2 2.7 0.6 1.2 1.6 0.4
Arm fat-free mass (left) 0.4 2.2 3.2 1.8 -0.7 1.8 -1.4
Number of operations (self-reported) 0.0 0.0 0.1 -0.1 0.3 -0.1 0.2
Average weekly beer plus cider intake 3.2 4.7 9.7 1.2 -1.7 -2.1 -3.1
Irritability 1.3 2.2 3.5 -0.5 -1.9 -1.6 -1.7
Risk taking 0.5 0.7 1.5 1.0 -0.2 -1.2 -0.3
Ever had prostate specific antigen (PSA) test 1.0 1.2 3.3 0.4 1.8 -1.1 0.0
Fractured/broken bones in last 5 years 0.9 1.1 1.9 1.4 0.8 -1.2 -0.8
Age started oral contraceptive pill 0.4 0.6 1.9 0.5 0.3 -1.4 -0.2
Diastolic blood pressure, automated reading 0.4 1.1 3.0 -1.7 0.3 -0.1 -1.2
Ever depressed for a whole week 3.1 3.8 8.4 -1.8 1.8 -0.2 2.9
Unable to work because of sickness or disability 0.3 0.4 1.0 -0.1 -1.0 -0.8 -0.3
Commuting to job workplace: Cycle 0.9 1.1 2.9 0.8 -1.7 -0.6 -0.6
Myopia 1.5 2.1 4.6 0.6 0.8 -1.7 -2.1
Vascular/heart problems diagnosed by doctor 1.2 3.2 6.7 1.5 -0.9 2.6 1.7
Cholesterol lowering medication 3.8 5.6 11.4 -2.8 3.4 -0.0 1.7
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 -0.3 -0.1 0.7 0.6
Pain experienced in last month 1.1 1.8 2.7 -1.4 1.6 1.1 1.2
Supplements: Calcium 1.4 1.5 5.5 -0.6 0.3 -2.4 0.1
Basal cell carcinoma (self-reported) 2.6 3.0 7.2 1.1 -1.8 0.8 -2.7
Heart attack/myocardial infarction (self-reported) 0.6 0.7 2.3 -1.5 -0.1 -0.2 0.8
Deep venous thrombosis (DVT) (self-reported) 1.4 1.9 2.9 0.7 -1.4 -1.4 -1.7
Heart disease (siblings) 1.4 1.8 3.6 0.4 1.9 1.4 1.2
Alcohol drinker status: Previous 0.1 0.1 0.4 -0.2 0.6 -0.2 0.2
Pack years of smoking 0.2 0.3 0.5 0.6 0.5 0.7 0.4
Impedance of whole body 0.1 0.7 1.4 -1.1 -0.1 -1.2 -0.2
Leg fat mass (left) 0.4 1.6 4.0 1.3 0.7 2.0 -0.5
Arm predicted mass (left) 0.4 2.1 3.5 1.5 -0.5 1.9 -1.4