Hub : Genes

DDI2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1245	0.0396	3.3e-04	0.067	NA	0.056	NA	0.046	3.7e-07	NA	3.1e-06	NA	2.2e-05
2	GTEx	Nerve Tibial	0.1227	0.0496	7.3e-03	-0.004	NA	0.003	NA	0.005	8.2e-01	NA	1.9e-01	NA	1.3e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.0939	0.0312	5.6e-05	0.024	0.038	0.015	0.04	0.025	3.9e-04	9.2e-06	3.8e-03	5.9e-06	2.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.3	1.6	1.2	1.3	0.9
Bipolar Disorder or Schizophrenia	0.5	1.2	1.6	1.3	0.7	1.2
Depressed Affect (Nagel 2018)	1.1	2.2	4.0	-0.7	-1.5	-2.0
Depression (Nagel 2018)	0.7	1.1	2.5	0.8	-0.3	-1.6
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	0.2	-0.1	-0.4
Neuroticism (Nagel 2018)	0.7	1.6	2.6	-0.8	-1.2	-1.6
Schizophrenia (2018)	0.2	0.4	0.7	0.6	-0.1	0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	-0.3	-1.1	0.2
Worry (Nagel 2018)	0.5	1.0	2.1	-0.7	-1.4	-0.5
Alzheimer’s Disease (in mother)	0.6	0.7	1.1	-1.0	-0.7	0.9
Alzheimer’s Disease (in father)	1.0	1.1	2.9	1.7	0.6	0.3
Alzheimer’s Disease (including proxy)	0.4	0.5	1.0	0.0	-0.7	1.0
Crohns Disease (2017)	0.9	2.0	4.6	-0.2	-2.1	1.2
Irritable Bowel Disease (IBD)	0.7	1.8	2.5	-1.0	-1.4	1.6
Ulcerative Colitis (UC)	0.6	1.2	2.0	-1.2	-0.3	1.4
Major Depression (MDD)	2.5	3.1	8.1	0.3	-1.0	2.9
Reaction Time	0.7	1.4	3.1	1.8	0.9	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	0.3	-0.4	0.6
Breast Cancer	1.1	2.8	8.1	-0.4	-0.1	2.8
Ovarian Cancer	1.3	1.7	3.4	-1.1	-1.9	-0.7
Prostate Cancer	0.5	0.7	1.6	0.2	-0.6	-1.3
Age at First Birth	0.1	0.2	0.3	0.5	-0.5	-0.3
Bipolar Disorder (2011)	1.4	1.3	1.6	-1.1	-1.3	1.1
Body Mass Index (BMI) (2010)	0.4	0.5	0.8	0.8	-0.9	0.3
Coronary Artery Disease (CAD)	0.6	0.7	1.3	1.1	0.3	-0.8
Crohns Disease (2012)	0.1	0.2	0.3	-0.5	-0.5	0.3
Mean Putamen Volume	1.3	1.5	4.2	-0.4	-2.0	0.3
Fasting Glucose	1.2	1.4	2.9	-1.7	-0.8	-0.8
HbA1C	0.2	0.2	0.7	0.1	0.8	-0.2
HDL Cholesterol	0.8	1.3	3.6	-1.9	0.5	-0.2
LDL Cholesterol	0.7	1.2	1.4	1.1	1.2	-1.0
Lupus	0.8	1.2	2.5	-1.0	-0.3	1.6
Neuroticism (2016)	0.7	1.1	2.5	-1.6	-0.5	-0.6
Primary Biliary Cirrhosis	0.0	0.1	0.1	0.0	-0.2	-0.3
Rheumatoid Arthritis	0.1	0.2	0.4	-0.5	-0.1	0.6
Schizophrenia (2014)	0.3	0.6	1.3	0.5	0.3	1.1
Triglycerides	0.2	0.3	0.9	1.0	-0.2	0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.3	0.2	0.1
Ulcerative Colitis	0.7	1.1	2.0	-0.8	1.4	0.8
Blood Eosinophil Count	0.2	1.7	4.6	-2.1	0.5	0.5
Blood Platelet Count	0.1	1.7	2.5	-1.4	-0.9	1.6
Blood Red Count	0.1	0.6	1.0	-1.0	0.3	0.8
Blood White Count	0.5	3.6	8.6	1.0	1.0	-2.9
Heel T-Score	2.8	21.9	64.0	-0.9	1.0	8.0
BMI	0.3	2.0	3.7	-0.7	-1.3	1.9
Height	0.1	1.1	1.6	1.0	-0.8	-1.3
Waist Hip Ratio (WHR)	0.3	1.2	2.1	-1.4	-1.2	0.2
Systolic Blood Pressure	4.2	21.2	36.1	3.9	3.5	-6.0
Smoking Status	1.2	2.9	8.0	0.9	0.0	-2.8
Allergy or Eczema	3.0	7.8	19.5	0.4	-1.9	-4.4
Cardiovascular Disease	3.3	11.0	15.2	2.6	3.3	-3.9
Hypothyroidism (self reported)	0.2	0.5	1.2	0.5	-1.1	-0.0
Respiratory disease	0.3	0.7	1.3	0.2	-0.8	-1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.8	-0.9	0.1	0.9
Lung FEV1/FVC ratio	0.1	0.7	1.6	-1.3	-0.6	0.3
Lung FVC	0.5	2.6	6.7	1.0	2.6	-0.4
Neuroticism	1.4	3.3	6.0	-0.6	-1.9	-2.5
Chronotype (morning person)	2.6	6.0	7.8	1.6	2.8	2.8
Hair Pigment	0.1	2.5	4.1	1.5	-2.0	1.0
Tanning	0.1	1.0	2.3	-0.3	0.7	1.5
Hand grip strength (left)	0.3	0.8	1.2	0.2	-1.1	-1.1
Number of treatments/medications taken	0.4	0.8	2.2	-0.2	-0.2	-1.5
Average weekly spirits intake	0.5	0.6	1.6	-1.2	0.2	-0.5
Sensitivity / hurt feelings	1.6	2.8	6.1	0.4	-1.4	-2.5
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.0	1.7	-0.2	-1.4
Hearing difficulty/problems: Yes	1.3	2.0	2.9	1.6	0.8	-1.7
Relative age of first facial hair	0.0	0.1	0.1	-0.2	0.3	0.1
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.9	1.5	-1.7	-0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	-0.9	0.0	0.2
Ever had hysterectomy (womb removed)	4.6	5.2	9.0	-3.0	-0.8	2.4
Systolic blood pressure, automated reading	3.1	8.9	18.0	2.6	1.4	-4.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.5	1.6	0.8	0.5
Angina	1.8	2.4	3.9	0.1	1.8	-2.0
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.4	0.5	0.6
Vitamin and mineral supplements	0.6	0.8	1.5	1.2	0.7	-0.5
Supplements: Zinc	0.6	0.7	1.3	1.1	-0.3	0.9
Medication: Co-codamol	1.0	1.2	2.5	-0.4	1.6	-1.0
Medication: Metformin	0.1	0.2	0.6	-0.0	-0.0	-0.8
Diabetes (father)	1.6	2.0	4.0	2.0	1.4	-0.4
Diabetes (mother)	0.8	1.0	2.6	-0.5	-0.1	1.6
Severe depression (siblings)	0.9	1.0	2.5	-1.6	0.6	-0.1
Pack years adult smoking proportion	0.8	1.2	1.8	-0.6	-1.3	-1.2
Impedance of leg (right)	0.3	1.6	2.3	-1.1	1.5	1.1
Leg fat-free mass (left)	0.1	0.8	1.7	0.4	-1.3	-0.7
Trunk fat percentage	0.3	1.1	2.9	-0.5	-0.3	1.7
Hand grip strength (right)	0.5	1.3	3.3	-0.3	-0.8	-1.8
Townsend deprivation index at recruitment	0.4	0.6	0.8	-0.9	0.6	-0.9
Current tobacco smoking	1.7	2.7	3.4	1.4	-1.7	-1.8
Average weekly fortified wine intake	1.0	1.1	1.8	-0.5	-1.3	-1.1
Maternal smoking around birth	1.5	2.2	5.8	0.8	2.4	0.3
Fed-up feelings	0.5	0.9	1.5	-0.2	-1.2	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.7	0.4	-0.8	-1.3
Relative age voice broke	0.9	1.4	2.7	0.4	1.6	1.2
Taking other prescription medications	1.0	1.6	1.9	-1.4	-1.0	-1.3
Age when periods started (menarche)	0.1	0.2	0.4	-0.6	-0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	5.9	6.8	14.3	-2.4	-0.2	3.8
Heel bone mineral density (BMD) T-score, automated (left)	4.0	9.1	18.8	-1.7	2.4	4.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.2	0.9	-0.4	-1.5
Qualifications: CSEs or equivalent	0.3	0.3	0.9	-0.3	-0.9	-0.1
Serious illness, injury or assault to yourself	1.1	1.3	2.0	-0.3	-1.4	1.4
High blood pressure	2.8	7.8	10.6	1.8	3.3	-3.1
Hayfever, allergic rhinitis or eczema	2.8	6.1	10.6	0.5	-2.7	-3.3
Multivitamins +/- minerals	1.5	1.9	3.1	-1.4	-1.8	0.7
Stomach or abdominal pain in last month	0.6	0.8	1.2	-0.2	1.1	-1.0
Supplements: Glucosamine	0.3	0.4	1.0	-0.3	-1.0	-0.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.4	1.0	-0.2	-1.2
Medication: Atenolol	0.6	0.8	1.7	1.3	0.8	-0.1
Medication: Levothyroxine sodium	0.1	0.1	0.1	0.3	0.3	-0.3
Sitting height	0.1	0.5	0.9	0.6	-1.0	-0.3
Chronic bronchitis/emphysema (father)	0.9	1.1	1.6	-1.3	0.4	1.2
High blood pressure (mother)	0.4	0.5	0.7	0.4	0.8	-0.8
Body mass index (BMI)	0.1	0.5	0.8	-0.1	-0.8	0.9
Impedance of leg (left)	0.1	0.4	1.0	0.0	1.0	0.5
Leg predicted mass (left)	0.2	0.8	1.7	0.4	-1.3	-0.8
Trunk fat mass	0.2	0.7	1.3	-0.2	-0.8	1.2
Waist circumference	0.3	0.9	1.6	-0.4	-1.3	1.0
Number of incorrect matches in round	0.8	1.3	2.0	1.4	-0.7	-1.1
Past tobacco smoking	0.5	0.9	2.0	-0.5	-0.6	1.4
Alcohol usually taken with meals	0.9	1.4	2.2	-0.6	1.3	1.5
Nervous feelings	0.0	0.1	0.1	0.2	0.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.0	0.3	-0.0	-1.4
Hearing difficulty/problems with background noise	1.5	2.3	4.2	2.1	1.6	-0.6
Hair/balding pattern: Pattern 2	1.6	2.0	2.7	1.6	0.9	-1.7
Had menopause	0.5	0.6	1.1	0.9	-0.2	1.0
Had other major operations	0.5	0.6	1.3	0.5	1.1	-0.4
Forced vital capacity (FVC)	0.4	1.4	2.5	1.6	0.7	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	3.1	7.2	19.8	-0.6	1.2	4.5
Ever unenthusiastic/disinterested for a whole week	2.5	3.1	6.8	-2.6	-1.5	-0.2
Qualifications: None of the above	0.3	0.5	0.9	1.0	0.3	-0.8
Financial difficulties in last 2 years	0.3	0.3	0.7	0.2	-0.8	0.5
Mouth/teeth dental problems	0.7	1.1	1.3	1.1	-1.0	1.1
Heart attack	0.9	1.2	1.6	-1.3	1.0	-0.9
Allergy	1.5	3.6	7.2	-1.0	1.6	2.7
Pain all over the body in last month	0.4	0.4	1.1	-1.1	0.0	0.3
Diabetes (self-reported)	0.0	0.0	0.0	-0.1	-0.0	-0.2
Hayfever/allergic rhinitis (self-reported)	4.8	6.3	15.7	-1.7	-4.0	-0.4
Medication: Ramipril	0.8	1.0	2.0	0.2	1.4	-0.9
Medication: Simvastatin	3.4	5.0	8.0	2.4	2.8	-1.1
Fluid intelligence score	0.2	0.4	0.8	-0.9	-0.6	-0.2
Illnesses of siblings	0.7	0.9	1.4	-0.4	-1.2	-1.1
Neuroticism score	0.8	1.6	3.2	-0.1	-1.2	-1.8
Weight	0.2	0.8	2.3	0.0	-1.5	0.4
Impedance of arm (right)	0.1	0.4	0.6	-0.8	0.7	-0.1
Arm fat percentage (right)	0.2	0.9	1.6	-0.7	-0.9	1.3
Trunk fat-free mass	0.3	1.5	3.1	0.9	-1.8	-0.8
Hip circumference	0.2	0.7	1.6	0.0	-1.3	0.6
Time employed in main current job	0.5	0.6	0.9	0.1	-1.0	0.9
Alcohol intake versus 10 years previously	0.8	1.2	1.7	-1.3	1.2	0.4
Father’s age at death	1.1	1.5	3.2	0.6	-1.0	1.8
Worrier / anxious feelings	0.4	0.8	1.6	-0.7	-1.3	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.6	-1.3	-0.5	0.8
Falls in the last year	0.6	0.8	1.2	-1.1	-0.6	-0.9
Hair/balding pattern: Pattern 3	0.3	0.5	1.2	0.1	0.5	1.1
Number of live births	0.5	0.7	2.0	-0.4	0.2	1.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	0.3	-0.6	-0.8
Pulse rate	0.3	0.6	1.4	-1.2	-0.5	-0.2
Happiness	0.3	0.3	0.4	-0.7	-0.4	0.6
Noisy workplace	1.0	1.3	2.4	0.8	1.5	-0.9
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	-0.5	0.5	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.3	0.2	-1.5	-0.2
Mouth/teeth dental problems: Dentures	0.4	0.6	1.4	0.1	1.2	-0.6
Asthma	0.4	0.8	2.3	0.2	-0.1	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.0	1.1	-1.0	-1.4
Medication: Cholesterol lowering	1.4	2.1	3.6	1.5	1.9	-0.7
Depression (self-reported)	0.2	0.3	0.5	0.7	0.4	-0.4
Medication: Lansoprazole	1.4	1.6	3.6	-0.1	-1.1	-1.9
Prospective memory result	2.2	2.7	5.4	1.1	1.3	2.3
Lung cancer (father)	0.9	1.0	1.2	-1.1	1.0	0.9
Illnesses of mother	0.3	0.4	0.9	-0.0	-1.0	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.4	-0.4	-0.7	-0.3
Pulse wave Arterial Stiffness index	0.4	0.5	0.8	0.4	0.6	0.9
Impedance of arm (left)	0.1	0.6	1.0	-1.0	0.2	0.8
Arm fat mass (right)	0.2	0.6	1.4	0.0	-1.2	0.7
Trunk predicted mass	0.3	1.6	3.2	0.9	-1.8	-0.9
Standing height	0.2	1.9	3.8	0.7	-1.9	-1.2
Length of working week for main job	0.6	0.7	1.0	1.0	0.4	-1.0
Exposure to tobacco smoke at home	0.3	0.4	0.5	-0.6	-0.7	0.5
Breastfed as a baby	0.1	0.2	0.5	0.1	-0.7	-0.1
Tense / ‘highly strung’	0.4	0.7	1.1	-1.0	-0.6	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.7	-0.7	-0.7	-0.9
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	-0.5	-0.9	0.6
Birth weight of first child	0.9	1.6	3.3	-0.8	-1.8	0.9
Peak expiratory flow (PEF)	0.2	0.6	1.3	0.5	-1.1	-0.3
Pulse wave reflection index	3.0	3.7	4.0	1.8	2.0	2.0
Ever highly irritable/argumentative for 2 days	1.3	1.5	3.2	-1.8	-1.1	-0.4
Loud music exposure frequency	0.1	0.1	0.3	-0.1	-0.3	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.8	0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	0.6	0.4	-1.3
Blood clot in the leg (DVT)	0.6	0.8	2.4	-0.1	1.6	-0.1
Medication: Paracetamol	1.3	2.1	3.0	1.6	-0.8	-1.7
Headache pain in last month	1.3	2.3	5.5	-2.4	-0.4	1.1
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	7.9	-1.2	-2.8	0.7
Glaucoma (self-reported)	0.7	0.9	1.7	1.3	0.8	-0.4
Gout (self-reported)	0.1	0.1	0.2	-0.2	0.3	0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.4	-0.2	-1.9	0.2
Medication: Amlodipine	0.9	1.3	3.4	-0.4	1.9	0.5
Medication: Ventolin 100micrograms inhaler	1.3	1.6	4.4	-2.1	-0.6	-0.4
Birth weight	0.9	1.9	5.2	-0.5	-2.3	0.4
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.5	-2.1	-1.1	0.5
High blood pressure (siblings)	0.5	0.8	1.3	0.9	1.1	0.2
Forced vital capacity (FVC), Best measure	0.1	0.2	0.3	0.6	-0.2	-0.5
Body fat percentage	0.3	1.3	3.3	-0.6	-0.5	1.8
Leg fat percentage (right)	0.5	1.9	4.5	-1.0	0.1	2.1
Arm fat-free mass (right)	0.2	1.2	2.3	0.9	-1.5	-0.6
Exposure to tobacco smoke outside home	0.2	0.3	0.7	-0.8	-0.3	0.0
Comparative body size at age 10	0.2	0.6	1.4	1.2	0.0	0.6
Number of full brothers	0.2	0.2	0.5	0.7	0.3	-0.1
Worry too long after embarrassment	0.9	1.4	3.1	-0.5	-1.0	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.2	-0.1	-0.0
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	-0.8	0.3	-0.4
Number of children fathered	2.0	2.3	6.5	-0.5	-2.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	4.7	1.1	2.2	0.5
Age at first live birth	0.6	1.1	2.2	0.8	-1.5	0.6
Pulse wave peak to peak time	0.6	0.8	1.3	-0.4	-0.9	-1.1
Health satisfaction	0.4	0.5	0.8	0.7	0.6	0.9
Shortness of breath walking on level ground	0.7	0.8	1.4	1.2	-0.6	0.9
Qualifications: College or University degree	0.1	0.5	1.0	-0.1	-1.0	-0.6
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.3	-0.9	0.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.5	-1.6	0.5	1.2
Emphysema/chronic bronchitis	0.2	0.2	0.3	0.4	0.5	0.5
Medication for pain relief, constipation, heartburn	0.7	1.3	2.6	-0.1	1.1	1.6
Neck or shoulder pain in last month	0.8	1.1	2.2	-0.5	-1.0	-1.5
Medication: Blood pressure	2.6	4.5	11.8	1.1	3.4	-0.7
Angina (self-reported)	1.9	2.5	3.9	0.1	1.9	-2.0
Migraine (self-reported)	1.4	1.7	5.1	-2.2	-0.3	-0.1
Medication: Ibuprofen	0.8	0.9	1.0	0.9	-1.0	-1.0
Medication: Allopurinol	0.8	1.0	2.3	0.8	-1.5	-0.4
Medication: Omeprazole	1.1	1.3	2.0	-1.2	-1.4	-0.5
Medication: Seretide 50 evohaler	0.1	0.2	0.5	-0.0	-0.0	-0.7
Mean time to correctly identify matches	0.5	0.9	2.0	1.4	0.8	0.4
Heart disease (mother)	0.1	0.2	0.4	-0.3	-0.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.7	0.0	1.3	-0.3
Whole body fat mass	0.2	0.6	1.1	-0.1	-0.9	1.0
Leg fat mass (right)	0.2	0.6	1.4	-0.3	-0.6	1.2
Arm predicted mass (right)	0.3	1.5	2.6	1.3	-1.6	-0.7
Pulse rate, automated reading	0.2	0.6	1.5	-1.2	-0.1	-0.4
Alcohol intake frequency.	2.1	4.8	11.2	-1.7	0.6	3.3
Comparative height size at age 10	0.5	2.6	7.7	0.2	-2.8	-0.2
Number of full sisters	1.0	1.2	3.3	-1.8	-0.3	0.3
Suffer from ‘nerves’	1.0	1.6	2.9	-1.4	-1.7	-0.2
Overall health rating	0.2	0.5	0.9	-0.4	0.6	-1.0
Chest pain or discomfort	0.7	0.9	1.2	-0.9	1.1	-0.9
Had major operations	0.2	0.2	0.3	-0.5	-0.5	-0.1
Age at last live birth	0.6	0.9	0.9	1.0	-0.9	0.9
Family relationship satisfaction	0.1	0.1	0.3	0.5	0.0	-0.3
Leg pain on walking	0.6	0.7	1.3	-0.9	1.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.3	0.2	1.5	-1.0
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.7	-0.8	0.7	-1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.7	0.1	-0.2	-1.3
Medication: Aspirin	0.8	1.0	2.3	0.5	1.5	-0.7
Supplements: Vitamin C	0.3	0.4	0.4	0.6	0.6	-0.6
Knee pain experienced in last month	1.0	1.5	3.2	1.0	0.6	-1.8
Hypertension (Self-reported)	2.5	6.8	9.5	1.9	2.8	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.6	-1.9	-0.6	-0.5
Illnesses of father: Heart disease	0.4	0.6	1.1	-0.7	0.2	-1.1
Illnesses of siblings: Diabetes	1.6	2.0	4.9	0.5	-0.8	2.2
Smoking status: Previous	0.8	1.2	2.6	0.5	1.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.4	0.4	-1.2	-1.0
Whole body fat-free mass	0.2	1.4	2.5	0.9	-1.6	-1.0
Leg fat-free mass (right)	0.3	1.8	2.7	1.0	-1.6	-1.3
Arm fat percentage (left)	0.4	1.5	2.8	-0.7	-1.0	1.7
Average weekly red wine intake	1.1	1.6	3.6	1.9	-1.0	-0.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	1.3	0.3	0.2
Mood swings	0.3	0.6	1.6	-0.4	-0.3	-1.3
Loneliness, isolation	1.6	2.2	5.6	-1.0	-2.4	0.4
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.5	0.1	-0.6
Ever had bowel cancer screening	0.1	0.2	0.3	-0.1	0.4	-0.5
Diabetes diagnosed by doctor	0.3	0.5	1.3	-1.1	0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.5	0.2	1.6	-0.2
Friendships satisfaction	1.0	1.2	1.8	-1.3	0.5	1.3
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.8	0.6	-0.2
Commuting to job workplace: Walk	0.8	0.9	1.6	1.0	1.3	0.1
Eye problems/disorders: Cataract	1.2	1.3	2.4	-0.9	-0.9	1.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.0	-0.5	-0.4	-1.4
Medication for cholesterol	0.3	0.4	1.1	-0.3	-1.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	1.5	-1.2	-1.1	-0.8
Back pain experienced in last month	1.7	2.5	6.9	0.8	-0.3	-2.6
Mineral and other dietary supplements	1.2	1.6	4.0	0.5	2.0	-0.7
Breast cancer (self-reported)	3.7	4.4	11.8	-1.1	-3.4	0.3
Asthma (self-reported)	0.2	0.4	1.3	-0.0	-0.2	-1.1
Osteoporosis (self-reported)	2.6	3.2	8.8	0.4	-0.8	-3.0
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.2	-0.3	0.1
Medication: Aspirin	0.7	1.0	2.4	0.5	1.5	-0.5
Medication: Gliclazide	0.8	0.9	1.5	0.8	1.2	-0.8
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	-0.2	-0.2	0.9
Smoking status: Current	0.9	1.5	2.3	0.8	-1.3	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.5	-1.6	0.8	0.7
Whole body water mass	0.3	1.5	2.6	0.9	-1.6	-1.0
Leg predicted mass (right)	0.3	1.7	2.9	0.9	-1.7	-1.2
Arm fat mass (left)	0.3	1.1	1.8	-0.4	-1.4	1.1
Number of self-reported non-cancer illnesses	0.5	0.9	1.9	-0.8	-0.5	-1.4
Average weekly champagne plus white wine intake	1.1	1.5	4.2	2.0	-0.1	-0.4
Miserableness	1.6	2.7	7.0	-0.6	-0.9	-2.6
Guilty feelings	0.1	0.2	0.2	-0.5	0.5	-0.3
Wears glasses or contact lenses	0.2	0.2	0.5	0.2	-0.3	0.7
Ever taken oral contraceptive pill	0.6	0.7	1.6	-1.2	0.3	0.6
Hearing aid user	1.2	1.3	2.9	-0.2	1.7	-1.0
Mother’s age at death	1.6	1.9	3.7	-1.9	-1.0	1.0
Financial situation satisfaction	1.9	2.4	5.0	1.3	2.2	0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.3	0.4	0.2
Commuting to job workplace: Public transport	0.2	0.2	0.6	0.8	-0.4	0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.3	-0.5	-0.3
Medication: Blood pressure	0.5	0.9	1.3	0.7	0.9	-1.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.2	0.2	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.4	-0.5	-1.2	0.2
High cholesterol (Self-reported)	1.6	2.8	7.1	0.5	2.7	-1.0
Medication: Bendroflumethiazide	1.0	1.5	2.8	0.2	1.7	1.3
Medication: Paracetamol	1.2	1.9	3.0	1.3	-1.0	-1.7
Medication: Lisinopril	1.0	1.3	3.5	0.3	1.9	-0.7
Medication: Atorvastatin	0.7	0.9	1.6	-1.0	0.3	1.3
Illnesses of father: High blood pressure	1.0	1.3	2.5	1.1	0.2	-1.6
Alcohol drinker status: Never	0.5	0.6	1.4	-1.2	-0.3	0.6
Ever smoked	0.6	1.1	2.8	0.3	-0.6	-1.7
Basal metabolic rate	0.2	1.1	2.3	0.7	-1.5	-0.7
Leg fat percentage (left)	0.3	1.0	2.8	-0.4	-0.3	1.7
Arm fat-free mass (left)	0.2	1.2	2.0	1.4	-1.0	-0.9
Number of operations (self-reported)	0.4	0.5	1.4	-0.1	1.2	0.4
Average weekly beer plus cider intake	1.5	2.1	5.5	-0.7	-0.6	-2.3
Irritability	0.4	0.7	1.4	0.8	0.3	-1.2
Risk taking	0.6	0.9	1.4	1.1	0.2	-1.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	0.4	-0.3	1.1
Fractured/broken bones in last 5 years	0.8	1.0	1.7	1.3	0.5	-1.0
Age started oral contraceptive pill	2.3	2.8	6.0	-1.3	-2.5	0.9
Diastolic blood pressure, automated reading	1.5	4.8	8.2	1.7	1.8	-2.9
Ever depressed for a whole week	0.4	0.6	1.2	-1.1	-0.6	-0.4
Unable to work because of sickness or disability	0.6	0.8	1.9	-0.4	-1.4	0.4
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.2	-0.5	0.4
Myopia	0.3	0.5	0.8	0.0	-0.9	0.7
Vascular/heart problems diagnosed by doctor	2.3	6.1	8.5	-1.3	-2.9	2.9
Cholesterol lowering medication	0.1	0.2	0.4	0.2	0.2	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.5	-1.6	-1.6	-0.3
Pain experienced in last month	0.4	0.6	1.8	0.1	-0.3	1.3
Supplements: Calcium	1.0	1.1	3.0	0.3	-1.7	-0.4
Basal cell carcinoma (self-reported)	2.4	2.8	3.1	1.8	1.8	-1.5
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.4	-1.2	1.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.3	-0.1	1.5	0.1
Heart disease (siblings)	0.3	0.3	0.7	-0.5	0.8	0.1
Alcohol drinker status: Previous	1.9	2.2	3.4	-1.9	0.8	1.6
Pack years of smoking	0.6	0.9	1.7	-0.5	-1.3	-0.9
Impedance of whole body	0.1	0.6	0.8	-0.6	0.9	0.9
Leg fat mass (left)	0.1	0.4	0.7	0.1	-0.8	0.8
Arm predicted mass (left)	0.2	1.3	1.3	1.1	-1.1	-1.1