Hub : Genes

DDI2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.1245 0.0396 3.3e-04 0.067 NA 0.056 NA 0.046 3.7e-07 NA 3.1e-06 NA 2.2e-05
2 GTEx Nerve Tibial 0.1227 0.0496 7.3e-03 -0.004 NA 0.003 NA 0.005 8.2e-01 NA 1.9e-01 NA 1.3e-01
3 ROSMAP Brain Pre-frontal Cortex 0.0939 0.0312 5.6e-05 0.024 0.038 0.015 0.04 0.025 3.9e-04 9.2e-06 3.8e-03 5.9e-06 2.7e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.8 1.3 1.6 1.2 1.3 0.9
Bipolar Disorder or Schizophrenia 0.5 1.2 1.6 1.3 0.7 1.2
Depressed Affect (Nagel 2018) 1.1 2.2 4.0 -0.7 -1.5 -2.0
Depression (Nagel 2018) 0.7 1.1 2.5 0.8 -0.3 -1.6
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.2 0.2 -0.1 -0.4
Neuroticism (Nagel 2018) 0.7 1.6 2.6 -0.8 -1.2 -1.6
Schizophrenia (2018) 0.2 0.4 0.7 0.6 -0.1 0.9
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 -0.3 -1.1 0.2
Worry (Nagel 2018) 0.5 1.0 2.1 -0.7 -1.4 -0.5
Alzheimer’s Disease (in mother) 0.6 0.7 1.1 -1.0 -0.7 0.9
Alzheimer’s Disease (in father) 1.0 1.1 2.9 1.7 0.6 0.3
Alzheimer’s Disease (including proxy) 0.4 0.5 1.0 0.0 -0.7 1.0
Crohns Disease (2017) 0.9 2.0 4.6 -0.2 -2.1 1.2
Irritable Bowel Disease (IBD) 0.7 1.8 2.5 -1.0 -1.4 1.6
Ulcerative Colitis (UC) 0.6 1.2 2.0 -1.2 -0.3 1.4
Major Depression (MDD) 2.5 3.1 8.1 0.3 -1.0 2.9
Reaction Time 0.7 1.4 3.1 1.8 0.9 0.5
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.3 0.3 -0.4 0.6
Breast Cancer 1.1 2.8 8.1 -0.4 -0.1 2.8
Ovarian Cancer 1.3 1.7 3.4 -1.1 -1.9 -0.7
Prostate Cancer 0.5 0.7 1.6 0.2 -0.6 -1.3
Age at First Birth 0.1 0.2 0.3 0.5 -0.5 -0.3
Bipolar Disorder (2011) 1.4 1.3 1.6 -1.1 -1.3 1.1
Body Mass Index (BMI) (2010) 0.4 0.5 0.8 0.8 -0.9 0.3
Coronary Artery Disease (CAD) 0.6 0.7 1.3 1.1 0.3 -0.8
Crohns Disease (2012) 0.1 0.2 0.3 -0.5 -0.5 0.3
Mean Putamen Volume 1.3 1.5 4.2 -0.4 -2.0 0.3
Fasting Glucose 1.2 1.4 2.9 -1.7 -0.8 -0.8
HbA1C 0.2 0.2 0.7 0.1 0.8 -0.2
HDL Cholesterol 0.8 1.3 3.6 -1.9 0.5 -0.2
LDL Cholesterol 0.7 1.2 1.4 1.1 1.2 -1.0
Lupus 0.8 1.2 2.5 -1.0 -0.3 1.6
Neuroticism (2016) 0.7 1.1 2.5 -1.6 -0.5 -0.6
Primary Biliary Cirrhosis 0.0 0.1 0.1 0.0 -0.2 -0.3
Rheumatoid Arthritis 0.1 0.2 0.4 -0.5 -0.1 0.6
Schizophrenia (2014) 0.3 0.6 1.3 0.5 0.3 1.1
Triglycerides 0.2 0.3 0.9 1.0 -0.2 0.2
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.1 -0.3 0.2 0.1
Ulcerative Colitis 0.7 1.1 2.0 -0.8 1.4 0.8
Blood Eosinophil Count 0.2 1.7 4.6 -2.1 0.5 0.5
Blood Platelet Count 0.1 1.7 2.5 -1.4 -0.9 1.6
Blood Red Count 0.1 0.6 1.0 -1.0 0.3 0.8
Blood White Count 0.5 3.6 8.6 1.0 1.0 -2.9
Heel T-Score 2.8 21.9 64.0 -0.9 1.0 8.0
BMI 0.3 2.0 3.7 -0.7 -1.3 1.9
Height 0.1 1.1 1.6 1.0 -0.8 -1.3
Waist Hip Ratio (WHR) 0.3 1.2 2.1 -1.4 -1.2 0.2
Systolic Blood Pressure 4.2 21.2 36.1 3.9 3.5 -6.0
Smoking Status 1.2 2.9 8.0 0.9 0.0 -2.8
Allergy or Eczema 3.0 7.8 19.5 0.4 -1.9 -4.4
Cardiovascular Disease 3.3 11.0 15.2 2.6 3.3 -3.9
Hypothyroidism (self reported) 0.2 0.5 1.2 0.5 -1.1 -0.0
Respiratory disease 0.3 0.7 1.3 0.2 -0.8 -1.1
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.8 -0.9 0.1 0.9
Lung FEV1/FVC ratio 0.1 0.7 1.6 -1.3 -0.6 0.3
Lung FVC 0.5 2.6 6.7 1.0 2.6 -0.4
Neuroticism 1.4 3.3 6.0 -0.6 -1.9 -2.5
Chronotype (morning person) 2.6 6.0 7.8 1.6 2.8 2.8
Hair Pigment 0.1 2.5 4.1 1.5 -2.0 1.0
Tanning 0.1 1.0 2.3 -0.3 0.7 1.5
Hand grip strength (left) 0.3 0.8 1.2 0.2 -1.1 -1.1
Number of treatments/medications taken 0.4 0.8 2.2 -0.2 -0.2 -1.5
Average weekly spirits intake 0.5 0.6 1.6 -1.2 0.2 -0.5
Sensitivity / hurt feelings 1.6 2.8 6.1 0.4 -1.4 -2.5
Frequency of depressed mood in last 2 weeks 1.2 1.7 3.0 1.7 -0.2 -1.4
Hearing difficulty/problems: Yes 1.3 2.0 2.9 1.6 0.8 -1.7
Relative age of first facial hair 0.0 0.1 0.1 -0.2 0.3 0.1
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 2.9 1.5 -1.7 -0.3
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.7 -0.9 0.0 0.2
Ever had hysterectomy (womb removed) 4.6 5.2 9.0 -3.0 -0.8 2.4
Systolic blood pressure, automated reading 3.1 8.9 18.0 2.6 1.4 -4.2
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.5 1.6 0.8 0.5
Angina 1.8 2.4 3.9 0.1 1.8 -2.0
Medication for hormone replacement therapy 0.2 0.2 0.3 -0.4 0.5 0.6
Vitamin and mineral supplements 0.6 0.8 1.5 1.2 0.7 -0.5
Supplements: Zinc 0.6 0.7 1.3 1.1 -0.3 0.9
Medication: Co-codamol 1.0 1.2 2.5 -0.4 1.6 -1.0
Medication: Metformin 0.1 0.2 0.6 -0.0 -0.0 -0.8
Diabetes (father) 1.6 2.0 4.0 2.0 1.4 -0.4
Diabetes (mother) 0.8 1.0 2.6 -0.5 -0.1 1.6
Severe depression (siblings) 0.9 1.0 2.5 -1.6 0.6 -0.1
Pack years adult smoking proportion 0.8 1.2 1.8 -0.6 -1.3 -1.2
Impedance of leg (right) 0.3 1.6 2.3 -1.1 1.5 1.1
Leg fat-free mass (left) 0.1 0.8 1.7 0.4 -1.3 -0.7
Trunk fat percentage 0.3 1.1 2.9 -0.5 -0.3 1.7
Hand grip strength (right) 0.5 1.3 3.3 -0.3 -0.8 -1.8
Townsend deprivation index at recruitment 0.4 0.6 0.8 -0.9 0.6 -0.9
Current tobacco smoking 1.7 2.7 3.4 1.4 -1.7 -1.8
Average weekly fortified wine intake 1.0 1.1 1.8 -0.5 -1.3 -1.1
Maternal smoking around birth 1.5 2.2 5.8 0.8 2.4 0.3
Fed-up feelings 0.5 0.9 1.5 -0.2 -1.2 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.7 0.4 -0.8 -1.3
Relative age voice broke 0.9 1.4 2.7 0.4 1.6 1.2
Taking other prescription medications 1.0 1.6 1.9 -1.4 -1.0 -1.3
Age when periods started (menarche) 0.1 0.2 0.4 -0.6 -0.5 -0.4
Bilateral oophorectomy (both ovaries removed) 5.9 6.8 14.3 -2.4 -0.2 3.8
Heel bone mineral density (BMD) T-score, automated (left) 4.0 9.1 18.8 -1.7 2.4 4.3
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 2.2 0.9 -0.4 -1.5
Qualifications: CSEs or equivalent 0.3 0.3 0.9 -0.3 -0.9 -0.1
Serious illness, injury or assault to yourself 1.1 1.3 2.0 -0.3 -1.4 1.4
High blood pressure 2.8 7.8 10.6 1.8 3.3 -3.1
Hayfever, allergic rhinitis or eczema 2.8 6.1 10.6 0.5 -2.7 -3.3
Multivitamins +/- minerals 1.5 1.9 3.1 -1.4 -1.8 0.7
Stomach or abdominal pain in last month 0.6 0.8 1.2 -0.2 1.1 -1.0
Supplements: Glucosamine 0.3 0.4 1.0 -0.3 -1.0 -0.0
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.4 1.0 -0.2 -1.2
Medication: Atenolol 0.6 0.8 1.7 1.3 0.8 -0.1
Medication: Levothyroxine sodium 0.1 0.1 0.1 0.3 0.3 -0.3
Sitting height 0.1 0.5 0.9 0.6 -1.0 -0.3
Chronic bronchitis/emphysema (father) 0.9 1.1 1.6 -1.3 0.4 1.2
High blood pressure (mother) 0.4 0.5 0.7 0.4 0.8 -0.8
Body mass index (BMI) 0.1 0.5 0.8 -0.1 -0.8 0.9
Impedance of leg (left) 0.1 0.4 1.0 0.0 1.0 0.5
Leg predicted mass (left) 0.2 0.8 1.7 0.4 -1.3 -0.8
Trunk fat mass 0.2 0.7 1.3 -0.2 -0.8 1.2
Waist circumference 0.3 0.9 1.6 -0.4 -1.3 1.0
Number of incorrect matches in round 0.8 1.3 2.0 1.4 -0.7 -1.1
Past tobacco smoking 0.5 0.9 2.0 -0.5 -0.6 1.4
Alcohol usually taken with meals 0.9 1.4 2.2 -0.6 1.3 1.5
Nervous feelings 0.0 0.1 0.1 0.2 0.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 2.0 0.3 -0.0 -1.4
Hearing difficulty/problems with background noise 1.5 2.3 4.2 2.1 1.6 -0.6
Hair/balding pattern: Pattern 2 1.6 2.0 2.7 1.6 0.9 -1.7
Had menopause 0.5 0.6 1.1 0.9 -0.2 1.0
Had other major operations 0.5 0.6 1.3 0.5 1.1 -0.4
Forced vital capacity (FVC) 0.4 1.4 2.5 1.6 0.7 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 3.1 7.2 19.8 -0.6 1.2 4.5
Ever unenthusiastic/disinterested for a whole week 2.5 3.1 6.8 -2.6 -1.5 -0.2
Qualifications: None of the above 0.3 0.5 0.9 1.0 0.3 -0.8
Financial difficulties in last 2 years 0.3 0.3 0.7 0.2 -0.8 0.5
Mouth/teeth dental problems 0.7 1.1 1.3 1.1 -1.0 1.1
Heart attack 0.9 1.2 1.6 -1.3 1.0 -0.9
Allergy 1.5 3.6 7.2 -1.0 1.6 2.7
Pain all over the body in last month 0.4 0.4 1.1 -1.1 0.0 0.3
Diabetes (self-reported) 0.0 0.0 0.0 -0.1 -0.0 -0.2
Hayfever/allergic rhinitis (self-reported) 4.8 6.3 15.7 -1.7 -4.0 -0.4
Medication: Ramipril 0.8 1.0 2.0 0.2 1.4 -0.9
Medication: Simvastatin 3.4 5.0 8.0 2.4 2.8 -1.1
Fluid intelligence score 0.2 0.4 0.8 -0.9 -0.6 -0.2
Illnesses of siblings 0.7 0.9 1.4 -0.4 -1.2 -1.1
Neuroticism score 0.8 1.6 3.2 -0.1 -1.2 -1.8
Weight 0.2 0.8 2.3 0.0 -1.5 0.4
Impedance of arm (right) 0.1 0.4 0.6 -0.8 0.7 -0.1
Arm fat percentage (right) 0.2 0.9 1.6 -0.7 -0.9 1.3
Trunk fat-free mass 0.3 1.5 3.1 0.9 -1.8 -0.8
Hip circumference 0.2 0.7 1.6 0.0 -1.3 0.6
Time employed in main current job 0.5 0.6 0.9 0.1 -1.0 0.9
Alcohol intake versus 10 years previously 0.8 1.2 1.7 -1.3 1.2 0.4
Father’s age at death 1.1 1.5 3.2 0.6 -1.0 1.8
Worrier / anxious feelings 0.4 0.8 1.6 -0.7 -1.3 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 1.6 -1.3 -0.5 0.8
Falls in the last year 0.6 0.8 1.2 -1.1 -0.6 -0.9
Hair/balding pattern: Pattern 3 0.3 0.5 1.2 0.1 0.5 1.1
Number of live births 0.5 0.7 2.0 -0.4 0.2 1.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.6 0.3 -0.6 -0.8
Pulse rate 0.3 0.6 1.4 -1.2 -0.5 -0.2
Happiness 0.3 0.3 0.4 -0.7 -0.4 0.6
Noisy workplace 1.0 1.3 2.4 0.8 1.5 -0.9
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.3 -0.5 0.5 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.3 0.2 -1.5 -0.2
Mouth/teeth dental problems: Dentures 0.4 0.6 1.4 0.1 1.2 -0.6
Asthma 0.4 0.8 2.3 0.2 -0.1 -1.5
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.0 1.1 -1.0 -1.4
Medication: Cholesterol lowering 1.4 2.1 3.6 1.5 1.9 -0.7
Depression (self-reported) 0.2 0.3 0.5 0.7 0.4 -0.4
Medication: Lansoprazole 1.4 1.6 3.6 -0.1 -1.1 -1.9
Prospective memory result 2.2 2.7 5.4 1.1 1.3 2.3
Lung cancer (father) 0.9 1.0 1.2 -1.1 1.0 0.9
Illnesses of mother 0.3 0.4 0.9 -0.0 -1.0 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.4 -0.4 -0.7 -0.3
Pulse wave Arterial Stiffness index 0.4 0.5 0.8 0.4 0.6 0.9
Impedance of arm (left) 0.1 0.6 1.0 -1.0 0.2 0.8
Arm fat mass (right) 0.2 0.6 1.4 0.0 -1.2 0.7
Trunk predicted mass 0.3 1.6 3.2 0.9 -1.8 -0.9
Standing height 0.2 1.9 3.8 0.7 -1.9 -1.2
Length of working week for main job 0.6 0.7 1.0 1.0 0.4 -1.0
Exposure to tobacco smoke at home 0.3 0.4 0.5 -0.6 -0.7 0.5
Breastfed as a baby 0.1 0.2 0.5 0.1 -0.7 -0.1
Tense / ‘highly strung’ 0.4 0.7 1.1 -1.0 -0.6 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 0.7 -0.7 -0.7 -0.9
Hair/balding pattern: Pattern 4 0.2 0.5 0.8 -0.5 -0.9 0.6
Birth weight of first child 0.9 1.6 3.3 -0.8 -1.8 0.9
Peak expiratory flow (PEF) 0.2 0.6 1.3 0.5 -1.1 -0.3
Pulse wave reflection index 3.0 3.7 4.0 1.8 2.0 2.0
Ever highly irritable/argumentative for 2 days 1.3 1.5 3.2 -1.8 -1.1 -0.4
Loud music exposure frequency 0.1 0.1 0.3 -0.1 -0.3 -0.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.7 -0.8 0.1 -0.4
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.7 0.6 0.4 -1.3
Blood clot in the leg (DVT) 0.6 0.8 2.4 -0.1 1.6 -0.1
Medication: Paracetamol 1.3 2.1 3.0 1.6 -0.8 -1.7
Headache pain in last month 1.3 2.3 5.5 -2.4 -0.4 1.1
Medication for cholesterol, blood pressure or diabetes 2.0 3.3 7.9 -1.2 -2.8 0.7
Glaucoma (self-reported) 0.7 0.9 1.7 1.3 0.8 -0.4
Gout (self-reported) 0.1 0.1 0.2 -0.2 0.3 0.4
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 3.4 -0.2 -1.9 0.2
Medication: Amlodipine 0.9 1.3 3.4 -0.4 1.9 0.5
Medication: Ventolin 100micrograms inhaler 1.3 1.6 4.4 -2.1 -0.6 -0.4
Birth weight 0.9 1.9 5.2 -0.5 -2.3 0.4
Chronic bronchitis/emphysema (mother) 1.7 2.0 4.5 -2.1 -1.1 0.5
High blood pressure (siblings) 0.5 0.8 1.3 0.9 1.1 0.2
Forced vital capacity (FVC), Best measure 0.1 0.2 0.3 0.6 -0.2 -0.5
Body fat percentage 0.3 1.3 3.3 -0.6 -0.5 1.8
Leg fat percentage (right) 0.5 1.9 4.5 -1.0 0.1 2.1
Arm fat-free mass (right) 0.2 1.2 2.3 0.9 -1.5 -0.6
Exposure to tobacco smoke outside home 0.2 0.3 0.7 -0.8 -0.3 0.0
Comparative body size at age 10 0.2 0.6 1.4 1.2 0.0 0.6
Number of full brothers 0.2 0.2 0.5 0.7 0.3 -0.1
Worry too long after embarrassment 0.9 1.4 3.1 -0.5 -1.0 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.0 -0.2 -0.1 -0.0
Wheeze or whistling in the chest in last year 0.2 0.3 0.7 -0.8 0.3 -0.4
Number of children fathered 2.0 2.3 6.5 -0.5 -2.6 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 4.7 1.1 2.2 0.5
Age at first live birth 0.6 1.1 2.2 0.8 -1.5 0.6
Pulse wave peak to peak time 0.6 0.8 1.3 -0.4 -0.9 -1.1
Health satisfaction 0.4 0.5 0.8 0.7 0.6 0.9
Shortness of breath walking on level ground 0.7 0.8 1.4 1.2 -0.6 0.9
Qualifications: College or University degree 0.1 0.5 1.0 -0.1 -1.0 -0.6
Eye problems/disorders: None of the above 0.3 0.3 0.8 0.3 -0.9 0.0
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.5 -1.6 0.5 1.2
Emphysema/chronic bronchitis 0.2 0.2 0.3 0.4 0.5 0.5
Medication for pain relief, constipation, heartburn 0.7 1.3 2.6 -0.1 1.1 1.6
Neck or shoulder pain in last month 0.8 1.1 2.2 -0.5 -1.0 -1.5
Medication: Blood pressure 2.6 4.5 11.8 1.1 3.4 -0.7
Angina (self-reported) 1.9 2.5 3.9 0.1 1.9 -2.0
Migraine (self-reported) 1.4 1.7 5.1 -2.2 -0.3 -0.1
Medication: Ibuprofen 0.8 0.9 1.0 0.9 -1.0 -1.0
Medication: Allopurinol 0.8 1.0 2.3 0.8 -1.5 -0.4
Medication: Omeprazole 1.1 1.3 2.0 -1.2 -1.4 -0.5
Medication: Seretide 50 evohaler 0.1 0.2 0.5 -0.0 -0.0 -0.7
Mean time to correctly identify matches 0.5 0.9 2.0 1.4 0.8 0.4
Heart disease (mother) 0.1 0.2 0.4 -0.3 -0.2 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.7 0.0 1.3 -0.3
Whole body fat mass 0.2 0.6 1.1 -0.1 -0.9 1.0
Leg fat mass (right) 0.2 0.6 1.4 -0.3 -0.6 1.2
Arm predicted mass (right) 0.3 1.5 2.6 1.3 -1.6 -0.7
Pulse rate, automated reading 0.2 0.6 1.5 -1.2 -0.1 -0.4
Alcohol intake frequency. 2.1 4.8 11.2 -1.7 0.6 3.3
Comparative height size at age 10 0.5 2.6 7.7 0.2 -2.8 -0.2
Number of full sisters 1.0 1.2 3.3 -1.8 -0.3 0.3
Suffer from ‘nerves’ 1.0 1.6 2.9 -1.4 -1.7 -0.2
Overall health rating 0.2 0.5 0.9 -0.4 0.6 -1.0
Chest pain or discomfort 0.7 0.9 1.2 -0.9 1.1 -0.9
Had major operations 0.2 0.2 0.3 -0.5 -0.5 -0.1
Age at last live birth 0.6 0.9 0.9 1.0 -0.9 0.9
Family relationship satisfaction 0.1 0.1 0.3 0.5 0.0 -0.3
Leg pain on walking 0.6 0.7 1.3 -0.9 1.1 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.3 0.2 1.5 -1.0
Commuting to job workplace: Car/motor vehicle 0.8 1.0 1.7 -0.8 0.7 -1.3
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.7 0.1 -0.2 -1.3
Medication: Aspirin 0.8 1.0 2.3 0.5 1.5 -0.7
Supplements: Vitamin C 0.3 0.4 0.4 0.6 0.6 -0.6
Knee pain experienced in last month 1.0 1.5 3.2 1.0 0.6 -1.8
Hypertension (Self-reported) 2.5 6.8 9.5 1.9 2.8 -3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 3.6 -1.9 -0.6 -0.5
Illnesses of father: Heart disease 0.4 0.6 1.1 -0.7 0.2 -1.1
Illnesses of siblings: Diabetes 1.6 2.0 4.9 0.5 -0.8 2.2
Smoking status: Previous 0.8 1.2 2.6 0.5 1.6 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 1.4 0.4 -1.2 -1.0
Whole body fat-free mass 0.2 1.4 2.5 0.9 -1.6 -1.0
Leg fat-free mass (right) 0.3 1.8 2.7 1.0 -1.6 -1.3
Arm fat percentage (left) 0.4 1.5 2.8 -0.7 -1.0 1.7
Average weekly red wine intake 1.1 1.6 3.6 1.9 -1.0 -0.2
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.7 1.3 0.3 0.2
Mood swings 0.3 0.6 1.6 -0.4 -0.3 -1.3
Loneliness, isolation 1.6 2.2 5.6 -1.0 -2.4 0.4
Long-standing illness, disability or infirmity 0.1 0.2 0.4 -0.5 0.1 -0.6
Ever had bowel cancer screening 0.1 0.2 0.3 -0.1 0.4 -0.5
Diabetes diagnosed by doctor 0.3 0.5 1.3 -1.1 0.2 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.5 0.2 1.6 -0.2
Friendships satisfaction 1.0 1.2 1.8 -1.3 0.5 1.3
Qualifications: nursing, teaching 0.2 0.3 0.6 -0.8 0.6 -0.2
Commuting to job workplace: Walk 0.8 0.9 1.6 1.0 1.3 0.1
Eye problems/disorders: Cataract 1.2 1.3 2.4 -0.9 -0.9 1.6
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.0 -0.5 -0.4 -1.4
Medication for cholesterol 0.3 0.4 1.1 -0.3 -1.1 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 1.5 -1.2 -1.1 -0.8
Back pain experienced in last month 1.7 2.5 6.9 0.8 -0.3 -2.6
Mineral and other dietary supplements 1.2 1.6 4.0 0.5 2.0 -0.7
Breast cancer (self-reported) 3.7 4.4 11.8 -1.1 -3.4 0.3
Asthma (self-reported) 0.2 0.4 1.3 -0.0 -0.2 -1.1
Osteoporosis (self-reported) 2.6 3.2 8.8 0.4 -0.8 -3.0
Osteoarthritis (self-reported) 0.0 0.0 0.1 0.2 -0.3 0.1
Medication: Aspirin 0.7 1.0 2.4 0.5 1.5 -0.5
Medication: Gliclazide 0.8 0.9 1.5 0.8 1.2 -0.8
Illnesses of father: None of the above (group 1) 0.2 0.3 0.7 -0.2 -0.2 0.9
Smoking status: Current 0.9 1.5 2.3 0.8 -1.3 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 2.5 -1.6 0.8 0.7
Whole body water mass 0.3 1.5 2.6 0.9 -1.6 -1.0
Leg predicted mass (right) 0.3 1.7 2.9 0.9 -1.7 -1.2
Arm fat mass (left) 0.3 1.1 1.8 -0.4 -1.4 1.1
Number of self-reported non-cancer illnesses 0.5 0.9 1.9 -0.8 -0.5 -1.4
Average weekly champagne plus white wine intake 1.1 1.5 4.2 2.0 -0.1 -0.4
Miserableness 1.6 2.7 7.0 -0.6 -0.9 -2.6
Guilty feelings 0.1 0.2 0.2 -0.5 0.5 -0.3
Wears glasses or contact lenses 0.2 0.2 0.5 0.2 -0.3 0.7
Ever taken oral contraceptive pill 0.6 0.7 1.6 -1.2 0.3 0.6
Hearing aid user 1.2 1.3 2.9 -0.2 1.7 -1.0
Mother’s age at death 1.6 1.9 3.7 -1.9 -1.0 1.0
Financial situation satisfaction 1.9 2.4 5.0 1.3 2.2 0.6
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 0.3 0.4 0.2
Commuting to job workplace: Public transport 0.2 0.2 0.6 0.8 -0.4 0.1
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 -0.3 -0.5 -0.3
Medication: Blood pressure 0.5 0.9 1.3 0.7 0.9 -1.2
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.1 0.2 0.2 0.1
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.4 -0.5 -1.2 0.2
High cholesterol (Self-reported) 1.6 2.8 7.1 0.5 2.7 -1.0
Medication: Bendroflumethiazide 1.0 1.5 2.8 0.2 1.7 1.3
Medication: Paracetamol 1.2 1.9 3.0 1.3 -1.0 -1.7
Medication: Lisinopril 1.0 1.3 3.5 0.3 1.9 -0.7
Medication: Atorvastatin 0.7 0.9 1.6 -1.0 0.3 1.3
Illnesses of father: High blood pressure 1.0 1.3 2.5 1.1 0.2 -1.6
Alcohol drinker status: Never 0.5 0.6 1.4 -1.2 -0.3 0.6
Ever smoked 0.6 1.1 2.8 0.3 -0.6 -1.7
Basal metabolic rate 0.2 1.1 2.3 0.7 -1.5 -0.7
Leg fat percentage (left) 0.3 1.0 2.8 -0.4 -0.3 1.7
Arm fat-free mass (left) 0.2 1.2 2.0 1.4 -1.0 -0.9
Number of operations (self-reported) 0.4 0.5 1.4 -0.1 1.2 0.4
Average weekly beer plus cider intake 1.5 2.1 5.5 -0.7 -0.6 -2.3
Irritability 0.4 0.7 1.4 0.8 0.3 -1.2
Risk taking 0.6 0.9 1.4 1.1 0.2 -1.2
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.1 0.4 -0.3 1.1
Fractured/broken bones in last 5 years 0.8 1.0 1.7 1.3 0.5 -1.0
Age started oral contraceptive pill 2.3 2.8 6.0 -1.3 -2.5 0.9
Diastolic blood pressure, automated reading 1.5 4.8 8.2 1.7 1.8 -2.9
Ever depressed for a whole week 0.4 0.6 1.2 -1.1 -0.6 -0.4
Unable to work because of sickness or disability 0.6 0.8 1.9 -0.4 -1.4 0.4
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.2 -0.5 0.4
Myopia 0.3 0.5 0.8 0.0 -0.9 0.7
Vascular/heart problems diagnosed by doctor 2.3 6.1 8.5 -1.3 -2.9 2.9
Cholesterol lowering medication 0.1 0.2 0.4 0.2 0.2 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 2.5 -1.6 -1.6 -0.3
Pain experienced in last month 0.4 0.6 1.8 0.1 -0.3 1.3
Supplements: Calcium 1.0 1.1 3.0 0.3 -1.7 -0.4
Basal cell carcinoma (self-reported) 2.4 2.8 3.1 1.8 1.8 -1.5
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.4 -1.2 1.1 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.3 -0.1 1.5 0.1
Heart disease (siblings) 0.3 0.3 0.7 -0.5 0.8 0.1
Alcohol drinker status: Previous 1.9 2.2 3.4 -1.9 0.8 1.6
Pack years of smoking 0.6 0.9 1.7 -0.5 -1.3 -0.9
Impedance of whole body 0.1 0.6 0.8 -0.6 0.9 0.9
Leg fat mass (left) 0.1 0.4 0.7 0.1 -0.8 0.8
Arm predicted mass (left) 0.2 1.3 1.3 1.1 -1.1 -1.1