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chr19:18,333,894-20,843,876

Best TWAS P=2.05e-26 · Best GWAS P=1.61e-29 conditioned to 0.00011

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Tibial	MEF2B	0.11	0.02	enet	9	0.06	2.6e-05	-5.2	5.4	7.1e-08	-0.41	0.79	0.09	FALSE
2	GTEx	Brain Hippocampus	DDX49	0.23	-0.01	lasso	4	-0.01	6.6e-01	-6.8	6.4	1.2e-10	-0.61	0.02	0.57	FALSE
3	GTEx	Cells Transformed fibroblasts	ATP13A1	0.14	0.06	lasso	5	0.05	2.2e-04	-10.6	-10.6	2.0e-26	0.93	0.18	0.57	TRUE
4	GTEx	Cells Transformed fibroblasts	GATAD2A	0.07	0.00	lasso	4	0.00	8.1e-01	-5.0	-8.5	2.0e-17	0.72	0.07	0.31	FALSE
5	GTEx	Cells Transformed fibroblasts	MEF2B	0.08	0.08	enet	15	0.09	1.7e-07	-5.5	5.6	1.9e-08	-0.48	0.84	0.02	FALSE
6	GTEx	Colon Sigmoid	RFXANK	0.19	-0.01	enet	38	0.02	9.2e-02	-10.0	5.4	6.6e-08	-0.42	0.03	0.35	FALSE
7	GTEx	Esophagus Mucosa	GATAD2A	0.11	0.02	lasso	3	0.02	2.3e-02	-6.3	-5.8	5.6e-09	0.64	0.06	0.57	FALSE
8	GTEx	Esophagus Mucosa	MEF2B	0.09	0.10	enet	10	0.09	1.2e-06	-5.5	5.2	1.7e-07	-0.50	0.86	0.03	FALSE
9	GTEx	Esophagus Muscularis	MEF2B	0.09	0.10	lasso	2	0.10	1.4e-06	-5.5	5.2	2.2e-07	-0.50	0.86	0.03	FALSE
10	GTEx	Muscle Skeletal	MAU2	0.09	0.04	lasso	4	0.05	5.1e-06	-6.5	6.6	5.0e-11	-0.59	0.99	0.01	FALSE
11	GTEx	Nerve Tibial	MEF2B	0.13	0.10	lasso	3	0.08	2.0e-06	-5.5	6.9	5.5e-12	-0.64	0.15	0.82	FALSE
12	GTEx	Prostate	ZNF682	0.61	0.00	lasso	17	0.00	3.9e-01	-1.5	-5.6	2.1e-08	0.48	0.02	0.40	FALSE
13	GTEx	Thyroid	MEF2B	0.15	0.16	lasso	1	0.16	5.1e-12	-5.5	5.5	3.6e-08	-0.53	1.00	0.00	FALSE
14	GTEx	Whole Blood	GATAD2A	0.06	0.02	lasso	9	0.03	1.7e-03	-5.2	-7.5	9.5e-14	0.63	0.36	0.53	FALSE
15	GTEx	Whole Blood	MEF2B	0.12	0.09	enet	9	0.11	1.5e-10	-5.5	5.8	9.1e-09	-0.49	1.00	0.00	FALSE
16	NTR	Blood	ATP13A1	0.01	0.01	blup	339	0.01	1.9e-04	-2.5	-6.2	6.7e-10	0.45	0.07	0.27	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	ATP13A1	0.10	0.07	lasso	5	0.06	1.3e-08	-7.9	8.5	1.5e-17	-0.78	0.14	0.85	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	MEF2B	0.05	0.01	blup	61	0.03	3.2e-06	-5.2	6.1	1.3e-09	-0.50	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAPLN4	0.05	0.07	lasso	2	0.06	1.1e-07	-5.3	-6.0	2.6e-09	0.48	0.99	0.01	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TM6SF2	0.04	0.03	blup	35	0.03	2.5e-04	-5.0	-8.3	8.4e-17	0.76	0.22	0.44	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMIP	0.07	0.00	blup	43	0.02	2.3e-02	-4.6	-5.7	1.5e-08	0.49	0.02	0.40	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	GATAD2A	0.04	0.03	lasso	2	0.03	2.9e-04	-5.0	-5.9	3.1e-09	0.52	0.25	0.37	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC729991-MEF2B	0.05	0.02	blup	66	0.01	2.1e-02	-5.5	-6.1	1.4e-09	0.56	0.00	0.91	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA0892	0.04	0.04	blup	43	0.02	4.1e-03	-5.4	5.4	5.2e-08	-0.43	0.53	0.05	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	TM6SF2	0.05	0.04	blup	34	0.05	2.8e-05	-5.0	-7.6	3.4e-14	0.71	0.29	0.55	FALSE