TWAS hub - PRKRA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2300	0.0710	1.9e-04	0.100	NA	0.122	NA	0.152	3.9e-04	NA	8.9e-05	NA	1.2e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.0703	0.0216	1.3e-07	0.103	0.062	0.101	0.099	0.101	3.6e-13	1.9e-08	5.8e-13	1.0e-12	6.0e-13
3	YFS	Blood	0.0197	0.0073	4.8e-06	0.030	0.019	0.028	0.023	0.028	4.1e-10	4.6e-07	1.5e-09	3.9e-08	1.1e-09
4	TCGA	Brain Lower Grade Glioma	0.0665	0.0496	4.3e-03	0.036	0.003	0.014	NA	0.028	5.1e-05	1.5e-01	7.9e-03	NA	3.5e-04
5	TCGA	Thyroid Carcinoma	0.0480	0.0240	1.0e-05	0.059	0.044	0.039	NA	0.051	2.0e-06	3.7e-05	1.0e-04	NA	9.7e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Risk taking	6.4	9.3	12.5	-2.3	3.0	3.3	3.0	3.5
Age at First Birth	5.7	8.3	9.6	-2.5	3.1	3.1	2.5	3.1
Alzheimer’s Disease (in father)	4.9	5.3	8.7	-0.1	-2.7	-2.9	-3.0	-1.4
Pulse rate, automated reading	4.9	15.7	27.6	0.1	-5.2	-4.8	-5.0	-1.7
Pulse rate	3.8	6.3	11.3	-0.6	-3.4	-3.0	-3.3	-0.2
Age at first live birth	3.8	6.8	7.7	-2.3	2.7	2.8	2.5	2.8
Age started oral contraceptive pill	3.7	4.7	7.1	-0.8	2.6	2.7	2.6	1.4
Gout (self-reported)	3.5	4.7	6.4	-1.0	2.5	2.5	2.1	2.4
Mouth/teeth dental problems: Bleeding gums	3.2	4.1	5.3	-2.0	1.9	2.3	1.8	2.1
Had menopause	3.1	3.9	5.4	1.4	-1.9	-2.1	-2.0	-2.3
Leg pain on walking	3.1	3.9	6.8	2.0	2.1	2.0	2.6	-0.3
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	4.9	0.1	2.2	2.2	2.2	1.3
Age at last live birth	3.0	4.3	5.7	-2.2	1.9	2.0	1.9	2.4
Ovarian Cancer	2.9	3.9	4.6	-1.5	2.1	2.1	1.8	2.1
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.4	6.2	-0.0	1.9	1.9	2.5	1.9
Ever smoked	2.7	4.8	8.4	0.2	2.8	2.9	2.5	1.3
Diabetes (father)	2.6	3.2	5.1	-0.5	2.3	2.2	1.8	1.5
Ever had bowel cancer screening	2.6	3.0	5.8	0.5	2.0	2.0	2.4	0.8
Mother’s age at death	2.6	3.2	5.3	-0.0	2.3	2.2	2.3	1.0
Alzheimer’s Disease (including proxy)	2.5	3.7	6.9	-1.4	-2.1	-2.2	-2.6	0.0
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	6.2	-0.8	2.3	2.2	1.6	2.5
Smoking status: Previous	2.4	3.6	6.0	1.2	2.2	2.3	2.4	0.5
Medication: Bendroflumethiazide	2.4	3.7	10.8	3.3	-0.8	-0.9	-0.2	-2.5
Alcohol drinker status: Previous	2.4	2.7	6.8	2.6	-1.0	-1.1	-0.9	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.0	5.4	0.4	2.1	2.2	2.3	0.6
Number of children fathered	2.3	2.6	4.9	2.1	-1.0	-1.3	-1.0	-2.2
Ever taken oral contraceptive pill	2.2	2.5	4.0	-0.5	1.6	1.9	2.0	1.4
Unable to work because of sickness or disability	2.2	2.8	3.2	1.6	-1.7	-1.8	-1.7	-1.6
Frequency of depressed mood in last 2 weeks	2.0	2.8	4.8	-0.3	2.1	2.2	1.8	1.2
Severe depression (siblings)	2.0	2.3	3.6	-0.2	-1.8	-1.8	-1.9	-1.2
Supplements: Glucosamine	1.9	2.5	4.3	0.3	2.0	1.9	2.1	0.8
Worrier / anxious feelings	1.8	3.5	6.4	0.2	2.2	2.2	2.5	1.2
Medication: Cholesterol lowering	1.8	2.8	3.6	-1.1	1.6	1.8	1.8	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	6.0	-1.9	1.0	1.3	1.0	2.5
Birth weight	1.8	3.9	4.2	-1.7	2.0	2.0	2.0	2.0
Medication: Allopurinol	1.8	2.3	6.1	-2.1	0.7	0.7	0.5	2.5
Medication: Omeprazole	1.8	2.2	3.5	-0.7	1.6	1.5	1.5	1.9
Ulcerative Colitis	1.7	2.5	6.5	1.9	-0.5	-0.7	-1.1	-2.6
Hearing difficulty/problems: Yes	1.7	2.7	9.8	3.1	0.0	-0.3	0.3	-1.8
Falls in the last year	1.7	2.3	4.5	-0.6	2.1	2.0	1.3	0.9
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	4.2	0.7	-2.1	-2.0	-1.5	-1.5
HbA1C	1.6	1.8	4.1	0.2	2.0	1.8	1.1	0.8
Hair/balding pattern: Pattern 2	1.6	2.0	5.4	-2.3	-0.9	-0.9	-1.6	0.5
Shortness of breath walking on level ground	1.6	1.9	3.2	1.2	1.6	1.8	1.4	0.2
Medication: Gliclazide	1.6	1.8	3.2	-1.8	1.0	1.2	1.1	1.5
Alcohol drinker status: Never	1.5	1.8	4.2	1.7	-0.7	-0.8	-1.0	-2.0
Fasting Glucose	1.4	1.6	2.8	-1.2	1.2	1.0	1.3	1.7
Hypothyroidism (self reported)	1.4	3.2	6.1	2.5	1.6	1.4	2.1	-0.9
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	2.9	0.7	-1.7	-1.6	-1.2	-1.0
Length of working week for main job	1.4	1.5	3.1	-0.4	-1.4	-1.4	-1.7	-0.6
Breastfed as a baby	1.4	1.7	3.4	1.6	-1.0	-1.1	-0.8	-1.9
Peak expiratory flow (PEF)	1.4	3.2	5.4	-2.3	1.5	1.5	1.2	2.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.3	-0.4	1.5	1.5	1.3	1.5
Chronic bronchitis/emphysema (mother)	1.4	1.7	2.9	0.1	1.5	1.6	1.7	0.9
Financial situation satisfaction	1.4	1.7	5.3	2.3	-0.5	-0.5	-0.5	-1.6
Pain type(s) experienced in last month: Hip pain	1.4	1.8	2.6	-0.4	1.4	1.5	1.6	1.3
Chronic bronchitis/emphysema (father)	1.3	1.5	2.5	0.7	-1.2	-1.3	-1.3	-1.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.2	0.7	-1.5	-1.3	-1.5	-1.2
Lung cancer (father)	1.3	1.5	2.2	-1.5	1.3	1.3	0.2	1.3
Friendships satisfaction	1.3	1.7	2.9	-0.5	-1.5	-1.5	-1.7	-0.7
Osteoporosis (self-reported)	1.3	1.6	2.4	1.0	-1.4	-1.3	-1.0	-1.5
Medication: Atorvastatin	1.3	1.6	3.2	0.1	-1.8	-1.5	-1.3	-0.8
Rheumatoid Arthritis	1.2	1.6	2.5	1.4	-0.8	-1.1	-1.6	-1.4
Prostate Cancer	1.1	1.6	3.4	-0.2	1.6	1.8	1.3	0.7
LDL Cholesterol	1.1	1.7	3.3	-0.4	1.7	1.8	1.3	0.7
Medication: Levothyroxine sodium	1.1	1.9	6.0	2.5	1.0	0.6	1.1	-1.0
Past tobacco smoking	1.1	2.0	3.1	-1.1	-1.7	-1.8	-1.7	-0.4
Worry too long after embarrassment	1.1	1.8	4.3	1.7	-0.9	-0.7	-0.6	-2.1
Medication: Ibuprofen	1.1	1.3	4.4	-2.1	-0.5	-0.4	-0.9	1.0
Had major operations	1.1	1.3	2.9	1.7	-0.5	-0.6	-0.4	-1.7
Number of operations (self-reported)	1.1	1.6	2.9	1.3	-1.1	-1.0	-1.2	-1.7
Diastolic blood pressure, automated reading	1.1	3.3	5.8	-0.1	-2.4	-2.2	-2.0	-1.4
Commuting to job workplace: Cycle	1.1	1.3	3.2	-1.8	0.7	0.7	0.6	1.4
HDL Cholesterol	1.0	1.6	2.8	0.2	-1.4	-1.6	-1.7	-1.0
Diabetes (mother)	1.0	1.2	2.1	-1.1	1.4	1.1	1.1	0.8
Pain all over the body in last month	1.0	1.1	1.9	1.4	1.2	1.0	1.0	-0.3
Diabetes (self-reported)	1.0	1.6	2.5	-1.6	1.0	1.0	1.1	1.4
Medication: Ramipril	1.0	1.3	2.5	0.5	-1.6	-1.5	-1.0	-0.7
Trunk fat-free mass	1.0	5.7	11.7	-3.4	1.8	2.1	1.6	2.6
Mouth/teeth dental problems: Dentures	1.0	1.6	2.4	1.5	-1.1	-1.1	-1.0	-1.6
Trunk predicted mass	1.0	5.9	11.8	-3.4	1.8	2.2	1.6	2.6
Alcohol intake frequency.	1.0	2.4	5.4	2.3	-0.8	-0.8	-0.8	-2.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.8	-1.7	-0.8	-1.0	-1.3	0.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.8	-0.7	1.3	1.2	1.3	1.0
Pack years adult smoking proportion	0.9	1.4	2.6	-1.1	-1.2	-1.2	-1.6	0.3
Stomach or abdominal pain in last month	0.9	1.1	3.0	-1.7	-0.3	-0.2	-0.2	1.5
Medication: Simvastatin	0.9	1.3	1.7	-0.4	1.3	1.2	1.2	1.3
Time employed in main current job	0.9	1.1	2.3	0.3	-1.1	-1.1	-1.5	-0.8
Pulse wave reflection index	0.9	1.1	2.6	0.8	1.2	1.0	1.6	0.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	5.1	2.3	0.9	0.7	1.1	-0.9
Exposure to tobacco smoke outside home	0.9	1.2	3.1	-1.0	0.7	0.8	0.9	1.8
Arm predicted mass (right)	0.9	4.4	6.5	-2.5	1.9	2.1	1.6	2.2
Back pain experienced in last month	0.9	1.3	2.1	0.6	-1.1	-1.4	-1.4	-1.2
Mineral and other dietary supplements	0.9	1.2	2.0	-0.6	-1.4	-1.2	-1.4	0.2
Irritability	0.9	1.5	3.3	0.8	1.3	1.2	1.8	0.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.9	-0.2	1.1	1.1	1.0	1.4
Ulcerative Colitis (UC)	0.8	1.5	2.6	1.1	-0.9	-1.1	-1.4	-1.6
Reaction Time	0.8	1.5	2.7	0.3	-1.6	-1.5	-1.2	-1.0
Lupus	0.8	1.3	3.2	-1.8	0.0	0.0	0.0	1.8
Systolic blood pressure, automated reading	0.8	2.2	4.1	1.2	-1.4	-1.5	-1.1	-2.0
Sitting height	0.8	5.6	11.7	-3.4	1.8	2.0	1.7	2.6
Alcohol usually taken with meals	0.8	1.3	3.4	-1.9	0.2	0.2	0.6	1.6
Father’s age at death	0.8	1.1	4.4	2.1	0.2	0.2	1.0	-0.5
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.5	1.9	-0.9	-0.7	-0.5	-1.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.0	0.8	-1.1	-1.2	-1.4	-1.1
Number of full brothers	0.8	1.1	2.7	-0.5	-1.0	-1.1	-1.6	0.1
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.9	1.4	0.7	0.9	1.1	-0.4
Migraine (self-reported)	0.8	1.1	2.0	0.3	1.1	1.4	1.4	0.4
Illnesses of father: Heart disease	0.8	1.1	2.6	-1.6	0.3	0.3	0.4	1.6
Arm predicted mass (left)	0.8	4.3	6.7	-2.6	1.9	2.0	1.5	2.2
Fed-up feelings	0.7	1.2	4.1	2.0	0.7	0.6	0.6	-0.9
High blood pressure (mother)	0.7	1.0	3.2	0.4	-0.8	-0.9	-0.2	-1.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	5.2	-2.3	1.0	1.0	1.1	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.1	-2.0	0.9	0.9	1.0	2.0
Impedance of arm (left)	0.7	3.0	4.2	1.9	-1.6	-1.7	-1.4	-2.0
Arm fat-free mass (right)	0.7	3.8	6.7	-2.6	1.6	1.8	1.4	2.1
Pulse wave peak to peak time	0.7	0.9	3.3	-1.8	-0.1	0.0	-0.7	0.8
Whole body fat-free mass	0.7	4.2	8.1	-2.8	1.6	1.9	1.5	2.1
Commuting to job workplace: Walk	0.7	0.7	1.4	-0.9	-1.2	-0.9	-0.8	-0.0
Whole body water mass	0.7	4.0	7.7	-2.8	1.6	1.9	1.5	2.0
Heart disease (siblings)	0.7	0.8	1.8	-1.3	-0.7	-0.6	-1.0	0.7
Bipolar Disorder (2018)	0.6	1.0	1.6	-0.3	-1.2	-1.1	-1.3	-0.7
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	-0.4	-1.0	-0.9	-1.2	0.1
Major Depression (MDD)	0.6	0.8	1.4	-1.2	-1.2	-1.0	-0.3	-0.4
Breast Cancer	0.6	1.5	3.3	1.7	-0.4	-0.6	-0.7	-1.8
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.0	-1.0	0.8	1.0	0.3	0.8
Lung FEV1/FVC ratio	0.6	3.1	5.3	-2.3	1.7	1.5	1.4	1.8
Ever had hysterectomy (womb removed)	0.6	0.7	1.8	-1.4	-0.7	-0.5	-0.8	0.3
Townsend deprivation index at recruitment	0.6	0.9	1.4	0.7	1.2	1.2	1.0	0.5
Current tobacco smoking	0.6	0.9	2.3	-0.2	-1.0	-1.0	-1.5	-0.1
Impedance of arm (right)	0.6	2.9	4.2	1.8	-1.5	-1.7	-1.4	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.8	-1.7	0.0	0.1	-0.5	1.1
Medication: Lansoprazole	0.6	0.6	1.0	-0.6	-0.9	-0.9	-1.0	0.5
Pulse wave Arterial Stiffness index	0.6	0.7	2.5	1.6	0.1	0.0	0.7	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.6	-0.5	-1.1	-1.0	-1.3	-0.2
Qualifications: College or University degree	0.6	1.8	5.9	-2.4	0.2	0.6	0.6	1.5
Overall health rating	0.6	1.3	3.3	1.8	1.1	1.0	1.1	-0.2
Knee pain experienced in last month	0.6	0.9	2.8	1.7	-0.0	0.0	-0.0	-1.4
Loneliness, isolation	0.6	0.8	1.2	1.1	0.9	0.9	0.9	-0.8
Long-standing illness, disability or infirmity	0.6	0.9	1.4	1.0	1.2	1.0	1.1	0.1
Diabetes diagnosed by doctor	0.6	1.0	1.9	-1.4	0.8	0.8	0.7	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.6	1.6	0.4	0.2	0.0	-0.8
Illnesses of father: None of the above (group 1)	0.6	0.7	1.4	0.8	1.2	1.1	0.6	0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	0.5	1.1	0.8	0.9	0.6
High cholesterol (Self-reported)	0.6	1.0	3.0	-1.2	0.5	0.4	0.3	1.7
Basal metabolic rate	0.6	3.3	6.4	-2.5	1.5	1.8	1.3	1.8
Arm fat-free mass (left)	0.6	3.2	5.6	-2.4	1.5	1.7	1.2	1.9
Depression (Nagel 2018)	0.5	0.8	1.5	0.4	1.1	1.1	1.2	0.2
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	0.6	1.2	1.0	0.6	0.5
Neuroticism (2016)	0.5	0.7	2.1	-1.4	0.6	0.3	0.3	1.0
Blood Eosinophil Count	0.5	3.8	6.1	1.7	-1.9	-1.9	-1.7	-2.5
Systolic Blood Pressure	0.5	2.4	6.7	1.3	-1.1	-1.4	-0.9	-2.6
Medication: Atenolol	0.5	0.7	1.0	0.9	-0.6	-0.7	-1.0	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.2	0.3	1.1	1.1	1.1	0.2
Allergy	0.5	1.2	1.6	1.1	-1.1	-1.1	-1.3	-1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.1	0.5	-0.6	-0.9	-0.9	-1.1
Alcohol intake versus 10 years previously	0.5	0.8	1.5	0.9	0.9	0.8	1.2	-0.2
Neck or shoulder pain in last month	0.5	0.7	1.1	-0.7	-0.9	-1.0	-1.0	0.5
Comparative height size at age 10	0.5	2.7	8.6	-2.9	0.9	0.9	0.6	1.7
Number of full sisters	0.5	0.6	2.1	1.5	0.4	0.6	0.7	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	-0.3	-1.0	-0.8	-0.7	-0.9
Guilty feelings	0.5	0.7	1.1	-0.1	1.0	1.1	0.9	0.9
Pack years of smoking	0.5	0.8	1.5	-0.7	-1.0	-1.0	-1.2	-0.1
Bipolar Disorder or Schizophrenia	0.4	0.9	2.0	-0.9	-0.8	-0.8	-1.4	-0.5
Schizophrenia (2014)	0.4	1.0	1.5	-0.3	-1.0	-1.0	-1.2	-1.2
Medication: Co-codamol	0.4	0.4	1.1	1.0	-0.4	-0.4	-0.2	-0.9
Taking other prescription medications	0.4	0.6	1.1	0.6	0.9	0.8	1.1	0.1
Qualifications: CSEs or equivalent	0.4	0.5	1.9	-1.4	-0.3	-0.2	-0.2	0.7
Multivitamins +/- minerals	0.4	0.5	0.8	-0.9	0.6	0.6	0.8	0.7
Hearing difficulty/problems with background noise	0.4	0.7	2.0	1.4	0.6	0.3	1.0	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.1	0.7	-0.8	-0.9	-0.8	-1.5
Qualifications: None of the above	0.4	0.8	3.5	1.9	0.2	0.1	0.3	-0.6
Financial difficulties in last 2 years	0.4	0.6	1.2	0.3	-0.8	-0.8	-1.1	-0.5
Standing height	0.4	3.6	8.4	-2.9	1.4	1.5	1.3	1.9
Exposure to tobacco smoke at home	0.4	0.4	0.7	-0.8	-0.2	-0.3	-0.8	0.7
Glaucoma (self-reported)	0.4	0.5	1.0	0.1	-0.7	-0.8	-1.0	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.1	1.5	0.1	0.0	0.2	-0.5
Supplements: Vitamin C	0.4	0.4	1.0	0.6	0.6	0.7	1.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.3	-1.5	0.0	0.0	0.2	1.2
Leg fat-free mass (right)	0.4	2.1	4.1	-2.0	1.1	1.5	1.2	1.3
Medication for cholesterol	0.4	0.7	1.6	-1.3	0.2	0.2	0.3	1.3
Leg predicted mass (right)	0.4	2.1	4.0	-2.0	1.1	1.5	1.2	1.3
Wears glasses or contact lenses	0.4	0.4	0.7	-0.5	0.8	0.6	0.8	0.5
Hearing aid user	0.4	0.5	1.2	1.1	0.6	0.5	0.6	-0.4
Illnesses of father: High blood pressure	0.4	0.5	0.9	-0.9	-0.7	-0.7	-0.8	-0.2
Myopia	0.4	0.5	1.2	1.1	0.4	0.2	-0.2	-1.1
Basal cell carcinoma (self-reported)	0.4	0.4	0.7	-0.6	0.4	0.6	0.7	0.9
Impedance of whole body	0.4	2.2	3.0	1.7	-1.2	-1.6	-1.3	-1.6
Blood Platelet Count	0.3	3.7	5.2	1.4	-2.2	-2.3	-1.5	-2.0
Blood Red Count	0.3	3.1	7.8	2.8	-0.7	-0.7	-0.6	-2.5
Height	0.3	6.7	10.4	-3.2	2.3	2.5	2.0	2.8
Smoking Status	0.3	0.7	1.2	-0.2	1.1	1.0	0.8	0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.7	-1.3	0.4	0.5	0.3	0.5
Hand grip strength (left)	0.3	0.8	2.2	0.2	0.8	1.0	1.5	0.4
Number of treatments/medications taken	0.3	0.6	0.9	-0.4	0.9	0.9	0.9	0.6
Sensitivity / hurt feelings	0.3	0.4	0.9	0.3	0.7	0.8	1.0	-0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.8	0.2	0.6	0.6	0.9	0.2
Vitamin and mineral supplements	0.3	0.4	1.4	0.1	-0.6	-0.6	-1.2	-0.1
Leg fat-free mass (left)	0.3	1.4	3.0	-1.7	0.8	1.2	0.9	1.0
Hand grip strength (right)	0.3	0.9	1.7	1.0	0.9	1.1	1.3	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.0	0.5	-0.8	-0.9	-0.6	-1.4
Serious illness, injury or assault to yourself	0.3	0.3	0.7	-0.9	-0.4	-0.4	-0.6	0.5
Number of incorrect matches in round	0.3	0.5	1.2	1.1	-0.4	-0.7	-0.0	-0.6
Nervous feelings	0.3	0.5	0.9	-1.0	0.6	0.5	0.5	0.8
Neuroticism score	0.3	0.7	1.4	1.2	0.7	0.8	0.8	-0.5
Weight	0.3	1.6	2.4	-1.3	1.3	1.6	1.1	1.0
Noisy workplace	0.3	0.4	1.1	-1.0	-0.0	-0.1	-0.4	0.9
Emphysema/chronic bronchitis	0.3	0.3	0.7	-0.2	-0.2	-0.4	-0.7	-0.8
Medication: Aspirin	0.3	0.5	1.1	-1.1	0.1	0.2	-0.1	1.0
Illnesses of siblings: Diabetes	0.3	0.4	1.0	0.1	0.9	1.0	0.3	0.3
Average weekly red wine intake	0.3	0.4	1.3	0.0	0.6	0.6	1.1	0.1
Mood swings	0.3	0.6	1.1	-0.1	0.9	1.0	0.7	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	-0.6	0.4	0.5	0.7	1.1
Medication: Aspirin	0.3	0.4	0.9	-0.9	0.4	0.4	0.1	1.0
Smoking status: Current	0.3	0.5	1.2	-0.5	-0.7	-0.7	-1.1	0.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.1	0.4	0.7	0.7	1.0	0.3
Average weekly champagne plus white wine intake	0.3	0.5	1.0	1.0	0.7	0.6	0.5	-0.5
Commuting to job workplace: Public transport	0.3	0.4	0.6	0.5	-0.8	-0.7	-0.4	-0.7
Medication: Blood pressure	0.3	0.6	2.2	1.5	0.0	0.1	-0.1	-1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.7	-0.0	0.8	0.7	0.6	-0.3
Average weekly beer plus cider intake	0.3	0.4	0.8	-0.0	0.9	0.8	0.8	0.3
Ever depressed for a whole week	0.3	0.4	0.8	-0.5	-0.7	-0.6	-0.9	-0.3
Supplements: Calcium	0.3	0.3	0.7	0.8	0.0	-0.0	-0.1	-0.8
Crohns Disease (2017)	0.2	0.5	1.5	-1.0	-0.1	0.1	0.2	1.2
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.5	-0.4	-0.4	-0.4	0.6
Mean Putamen Volume	0.2	0.2	1.1	-1.0	-0.1	-0.1	0.0	0.3
Medication for hormone replacement therapy	0.2	0.2	0.4	0.6	0.3	0.2	0.3	-0.6
Medication: Metformin	0.2	0.3	1.2	-1.1	0.2	0.2	0.2	0.5
Impedance of leg (right)	0.2	0.8	1.3	1.1	-0.5	-0.9	-0.8	-0.8
Trunk fat percentage	0.2	0.6	2.1	1.4	0.3	0.3	0.1	-0.9
Age when periods started (menarche)	0.2	0.6	1.3	-0.2	-1.1	-0.9	-0.9	0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-0.2	0.8	0.7	1.0	0.4
Leg predicted mass (left)	0.2	1.2	2.8	-1.7	0.7	1.1	0.9	1.0
Had other major operations	0.2	0.3	0.6	-0.3	0.4	0.6	0.5	0.7
Forced vital capacity (FVC)	0.2	0.9	1.7	-1.3	0.6	0.6	0.7	1.3
Mouth/teeth dental problems	0.2	0.4	0.7	-0.2	-0.6	-0.8	-0.8	-0.5
Fluid intelligence score	0.2	0.5	1.2	-1.1	-0.5	-0.4	-0.7	0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.3	-0.7	-0.7	-0.6	-0.4
Prospective memory result	0.2	0.3	0.7	-0.3	-0.8	-0.7	0.1	-0.3
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	0.6	-0.0	0.2	1.0	0.9
Headache pain in last month	0.2	0.4	1.3	-1.1	0.1	0.0	0.6	0.7
High blood pressure (siblings)	0.2	0.3	0.7	0.7	0.2	0.2	-0.3	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.8	1.7	-1.1	0.6	0.5	0.7	1.3
Comparative body size at age 10	0.2	0.5	0.7	0.8	-0.6	-0.6	-0.8	-0.8
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	0.4	-0.6	-0.7	-0.6	-0.2
Health satisfaction	0.2	0.3	0.6	0.8	-0.5	-0.3	-0.4	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.4	1.3	1.1	0.1	0.1	0.4	-0.8
Mean time to correctly identify matches	0.2	0.4	0.7	0.6	-0.8	-0.7	-0.3	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.6	0.3	-0.7	-0.6	-0.5	-0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	0.4	-0.7	-0.7	-0.0	-0.6
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.7	-0.5	-0.5	-0.5	-0.0
Breast cancer (self-reported)	0.2	0.2	0.5	0.6	0.0	-0.1	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.7	-1.3	-0.3	-0.4	-0.4	0.7
Medication: Lisinopril	0.2	0.2	0.4	-0.6	-0.5	-0.3	-0.7	0.1
Cholesterol lowering medication	0.2	0.3	0.5	0.5	-0.5	-0.6	-0.7	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	-0.7	0.4	0.6	0.9	0.4
Neuroticism (Nagel 2018)	0.1	0.2	0.4	0.6	-0.0	-0.3	0.2	-0.6
Schizophrenia (2018)	0.1	0.3	0.7	-0.8	-0.2	-0.3	-0.8	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	0.0	-0.6	-0.6	-0.3	-0.6
Bipolar Disorder (2011)	0.1	0.1	0.3	0.1	0.3	0.5	0.4	-0.2
Crohns Disease (2012)	0.1	0.2	0.4	-0.0	0.2	0.3	0.7	0.6
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.1	0.6	0.6	0.1	-0.5
Triglycerides	0.1	0.2	0.5	0.4	0.7	0.7	0.1	-0.1
Heel T-Score	0.1	0.5	1.0	-0.8	0.5	0.4	0.5	1.0
Allergy or Eczema	0.1	0.3	0.7	0.7	-0.3	-0.4	-0.2	-0.8
Cardiovascular Disease	0.1	0.4	0.6	-0.8	-0.7	-0.8	-0.6	-0.4
Chronotype (morning person)	0.1	0.2	0.4	-0.1	0.6	0.5	0.6	0.2
Hair Pigment	0.1	3.1	6.1	-0.7	-2.5	-2.3	-2.0	-0.1
Tanning	0.1	0.8	1.8	-1.4	-0.8	-0.6	-1.0	0.3
Average weekly spirits intake	0.1	0.1	0.3	0.5	0.2	0.1	0.1	0.2
Relative age of first facial hair	0.1	0.2	0.4	-0.2	0.6	0.5	0.4	0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.5	0.4	0.2	0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	0.1	-0.6	-0.4	-0.4	0.1
Angina	0.1	0.1	0.4	0.1	-0.1	-0.1	-0.6	0.1
Supplements: Zinc	0.1	0.1	0.2	-0.0	0.1	0.1	0.4	0.4
High blood pressure	0.1	0.1	0.3	0.6	0.2	0.2	0.3	-0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.5	-0.3	-0.3	-0.3	-0.2
Body mass index (BMI)	0.1	0.3	0.7	0.0	0.7	0.9	0.5	0.1
Impedance of leg (left)	0.1	0.3	0.6	0.7	-0.2	-0.6	-0.5	-0.4
Trunk fat mass	0.1	0.3	0.7	0.2	0.8	0.8	0.6	-0.0
Heart attack	0.1	0.1	0.1	-0.2	-0.3	-0.3	-0.3	-0.0
Illnesses of siblings	0.1	0.1	0.2	-0.2	-0.3	-0.4	0.2	0.3
Arm fat percentage (right)	0.1	0.3	1.2	1.1	0.1	0.2	0.0	-0.5
Number of live births	0.1	0.1	0.3	0.2	0.5	0.4	-0.2	-0.0
Happiness	0.1	0.1	0.4	-0.3	-0.3	-0.1	-0.4	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.3	-0.1	0.2	0.3	0.5
Asthma	0.1	0.2	0.6	-0.8	-0.3	-0.5	-0.3	0.1
Depression (self-reported)	0.1	0.1	0.2	-0.3	-0.1	0.1	-0.4	-0.2
Illnesses of mother	0.1	0.1	0.3	0.6	-0.1	0.2	0.1	0.2
Arm fat mass (right)	0.1	0.4	1.0	-0.1	0.9	1.0	0.6	0.3
Tense / ‘highly strung’	0.1	0.1	0.3	0.6	0.3	0.1	0.1	-0.5
Birth weight of first child	0.1	0.2	0.6	0.7	0.5	0.3	0.3	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.3	0.6	0.2	0.1	0.5	-0.0
Medication: Paracetamol	0.1	0.1	0.4	-0.6	-0.0	-0.1	-0.1	0.3
Medication: Amlodipine	0.1	0.2	0.6	-0.8	-0.4	-0.2	-0.2	0.1
Body fat percentage	0.1	0.5	1.6	1.3	0.3	0.3	0.1	-0.7
Leg fat percentage (right)	0.1	0.4	1.0	1.0	0.7	0.6	0.4	-0.3
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.1	0.4	0.3	0.2	0.1
Medication: Blood pressure	0.1	0.1	0.2	0.4	-0.1	-0.0	0.4	-0.3
Angina (self-reported)	0.1	0.2	0.8	0.0	-0.3	-0.3	-0.9	0.0
Heart disease (mother)	0.1	0.1	0.2	-0.4	0.1	-0.2	-0.4	0.3
Whole body fat mass	0.1	0.3	0.7	0.2	0.7	0.8	0.6	0.0
Leg fat mass (right)	0.1	0.4	0.8	-0.1	0.8	0.9	0.7	0.4
Suffer from ‘nerves’	0.1	0.1	0.3	0.2	-0.4	-0.1	0.1	-0.6
Chest pain or discomfort	0.1	0.2	0.5	0.0	0.7	0.6	0.4	0.1
Family relationship satisfaction	0.1	0.2	0.3	-0.1	0.5	0.6	0.5	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.1	0.2	0.3	0.5	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.0	0.4	0.3	-0.3	0.5
Arm fat percentage (left)	0.1	0.3	1.2	1.1	0.1	0.2	0.0	-0.6
Qualifications: nursing, teaching	0.1	0.1	0.5	0.2	0.2	0.1	0.2	-0.7
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.5	-0.5	-0.6	-0.2	-0.0
Arm fat mass (left)	0.1	0.4	1.0	-0.0	0.9	1.0	0.6	0.3
Miserableness	0.1	0.2	0.4	0.5	0.6	0.5	0.4	-0.1
Medication: Paracetamol	0.1	0.1	0.3	-0.2	-0.5	-0.5	-0.3	-0.1
Leg fat percentage (left)	0.1	0.4	0.6	0.8	0.8	0.7	0.5	-0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.4	0.2	-0.0	0.1	0.3
Fractured/broken bones in last 5 years	0.1	0.1	0.4	-0.2	0.7	0.4	0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.1	-0.4	-0.5	-0.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.6	0.8	0.2	0.1	0.5	-0.1
Leg fat mass (left)	0.1	0.5	1.0	-0.2	0.9	1.0	0.7	0.5
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	0.4	-0.0	-0.2	-0.2	-0.4
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	-0.3	0.3	0.2	0.2	0.1
Worry (Nagel 2018)	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.4	-0.1
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	-0.4	-0.2	-0.3	-0.4	0.2
Blood White Count	0.0	0.3	0.5	0.4	0.7	0.7	0.5	-0.0
BMI	0.0	0.2	0.7	0.8	-0.1	-0.1	0.1	-0.6
Waist Hip Ratio (WHR)	0.0	0.2	0.3	0.6	-0.5	-0.6	-0.2	-0.2
Respiratory disease	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.1
Lung FVC	0.0	0.1	0.6	0.8	0.2	0.1	-0.1	0.2
Neuroticism	0.0	0.1	0.1	0.3	0.1	0.0	0.4	0.1
Average weekly fortified wine intake	0.0	0.0	0.1	0.3	0.1	0.1	-0.3	-0.1
Maternal smoking around birth	0.0	0.0	0.1	-0.3	-0.2	-0.1	-0.0	-0.0
Relative age voice broke	0.0	0.0	0.2	0.1	-0.0	-0.1	-0.1	-0.5
Waist circumference	0.0	0.1	0.2	0.2	0.3	0.4	0.1	-0.4
Hip circumference	0.0	0.2	0.5	-0.2	0.3	0.4	-0.0	-0.7
Loud music exposure frequency	0.0	0.0	0.1	0.0	-0.2	-0.1	-0.1	-0.3
Medication: Seretide 50 evohaler	0.0	0.1	0.3	0.5	0.1	0.1	0.0	-0.0
Hypertension (Self-reported)	0.0	0.1	0.2	0.4	0.1	0.1	0.1	-0.5
Asthma (self-reported)	0.0	0.1	0.1	-0.3	-0.2	-0.3	-0.2	-0.1
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	0.1
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.2	-0.1	-0.1	-0.2	0.4
Pain experienced in last month	0.0	0.0	0.1	-0.3	-0.1	0.2	0.2	0.3

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