TWAS hub - TTN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.217	0.0400	0.0e+00	0.214	0.164	0.199	0.218	0.206	1.5e-25	1.9e-19	1.2e-23	5.2e-26	1.6e-24
2	ROSMAP	Brain Pre-frontal Cortex	0.173	0.0393	2.4e-10	0.140	0.081	0.145	0.146	0.144	1.4e-17	1.3e-10	3.0e-18	2.9e-18	4.7e-18
3	TCGA	Thyroid Carcinoma	0.036	0.0210	4.6e-03	0.013	0.002	0.005	NA	0.007	1.8e-02	2.0e-01	9.4e-02	NA	5.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pulse rate, automated reading	19.0	61.4	76.2	-8.0	-6.6	8.7
Pulse rate	11.1	18.7	26.6	-4.3	-3.3	5.2
Pulse wave reflection index	4.0	4.9	6.4	2.3	1.8	-2.5
Number of children fathered	3.8	4.3	6.5	2.5	2.5	0.5
Diastolic blood pressure, automated reading	3.7	11.5	12.5	-3.5	-3.1	3.5
Leg pain on walking	3.2	4.0	4.6	2.2	1.9	-1.9
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	7.1	-1.2	-0.9	-2.7
Eye problems/disorders: None of the above	2.9	3.4	4.8	2.1	2.2	-0.8
Ever had hysterectomy (womb removed)	2.8	3.1	4.5	-2.0	-2.1	0.9
Had other major operations	2.8	3.5	5.4	-2.3	-2.2	0.2
Tinnitus: Yes, now most or all of the time	2.7	3.1	5.3	2.3	1.4	-1.4
Age at First Birth	2.5	3.6	8.6	-1.0	-1.1	-2.9
Hair/balding pattern: Pattern 2	2.5	3.1	4.1	-2.0	-2.0	1.2
Myopia	2.5	3.7	6.1	2.2	2.5	-0.5
Number of operations (self-reported)	2.3	3.4	5.1	-1.7	-2.3	1.5
Risk taking	2.3	3.4	4.4	-1.3	-2.1	-2.0
Hearing difficulty/problems with background noise	2.2	3.4	6.2	2.5	1.8	-1.0
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	3.8	-1.8	-1.9	0.6
Medication: Amlodipine	2.2	3.0	4.9	-2.2	-1.9	0.8
Commuting to job workplace: Public transport	2.1	2.5	3.6	1.9	1.7	1.1
Alzheimer’s Disease (in father)	2.0	2.2	4.5	-1.0	-1.0	2.1
Alzheimer’s Disease (including proxy)	2.0	2.9	4.1	-1.6	-1.4	2.0
HDL Cholesterol	2.0	3.4	5.7	2.0	2.4	0.5
Other serious medical condition/disability diagnosed by doctor	2.0	2.7	4.2	-1.9	-2.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	5.5	-1.3	-1.6	-2.4
Prospective memory result	2.0	2.5	2.8	-1.6	-1.7	1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.5	-1.4	-1.2	-1.9
Ever smoked	2.0	3.6	5.6	-1.3	-1.9	-2.4
HbA1C	1.8	2.0	5.8	0.4	0.2	-2.4
Hearing difficulty/problems: Yes	1.8	2.8	6.4	2.5	1.4	-0.1
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	5.6	1.2	1.2	2.4
Medication: Aspirin	1.8	2.4	3.7	-1.9	-1.8	0.5
Illnesses of siblings: Diabetes	1.7	2.1	4.1	-1.4	-2.0	-0.6
Verbal and Numeric Reasoning (VNR)	1.6	3.8	5.9	2.4	2.3	-0.0
Number of incorrect matches in round	1.6	2.6	3.8	1.9	1.9	-0.7
Lung cancer (father)	1.6	1.8	2.5	-1.4	-1.6	-1.0
Medication: Gliclazide	1.6	1.8	2.9	-1.5	-1.7	-0.5
Wears glasses or contact lenses	1.6	1.9	2.3	-1.5	-1.5	-1.1
Age started oral contraceptive pill	1.6	2.0	3.2	-1.1	-1.2	-1.8
Unable to work because of sickness or disability	1.6	2.1	3.2	1.3	1.2	1.8
Rheumatoid Arthritis	1.5	2.0	3.7	1.9	1.4	0.6
Gout (self-reported)	1.5	2.1	6.1	0.3	0.3	-2.5
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.7	0.9	0.9	-1.9
Mineral and other dietary supplements	1.5	2.0	5.7	-0.3	-0.4	2.4
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.2	-1.2	-1.1	1.5
Supplements: Glucosamine	1.4	1.9	5.1	0.2	0.7	-2.3
Had menopause	1.4	1.7	2.9	-1.1	-1.0	1.7
Impedance of arm (right)	1.4	6.6	10.9	2.8	3.3	1.1
Depression (self-reported)	1.4	1.7	3.9	-1.1	-2.0	0.0
Breastfed as a baby	1.4	1.7	2.2	1.5	1.5	0.9
Number of full sisters	1.4	1.7	2.6	1.5	1.6	-0.2
Ever had bowel cancer screening	1.4	1.7	5.0	0.0	-0.3	-2.2
Osteoporosis (self-reported)	1.4	1.7	2.6	-1.1	-1.2	1.6
Medication: Levothyroxine sodium	1.3	2.2	3.6	1.9	1.4	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	3.8	-1.2	-2.0	-0.8
Hearing aid user	1.3	1.5	3.3	-1.1	-1.8	0.2
Supplements: Calcium	1.3	1.4	2.3	-1.3	-1.5	-0.6
Schizophrenia (2018)	1.2	2.5	4.6	-2.2	-1.6	0.5
Fasting Glucose	1.2	1.4	3.5	0.7	0.7	-1.9
Qualifications: CSEs or equivalent	1.2	1.6	2.8	-1.7	-1.2	0.8
Diabetes (self-reported)	1.2	1.9	2.7	-1.6	-1.6	-0.6
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.3	0.5	0.9	-1.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.2	-1.3	-1.5	-0.9
High blood pressure (siblings)	1.2	1.8	2.9	-1.7	-1.6	0.2
Arm fat-free mass (right)	1.2	6.4	9.2	-2.9	-3.0	-1.3
Arm predicted mass (right)	1.2	6.1	8.4	-2.7	-2.9	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.0	1.4	1.1	-0.8
Illnesses of father: None of the above (group 1)	1.2	1.5	3.7	0.4	0.7	-1.9
Medication: Bendroflumethiazide	1.2	1.8	2.9	1.6	1.7	0.1
Medication: Lisinopril	1.2	1.5	2.3	-1.5	-1.5	-0.0
Medication: Atorvastatin	1.2	1.5	4.4	-0.1	0.0	2.1
Alcohol drinker status: Never	1.2	1.4	2.5	1.3	1.6	0.3
Arm predicted mass (left)	1.2	5.9	7.9	-2.7	-2.8	-1.5
LDL Cholesterol	1.1	1.8	3.1	-1.1	-1.0	-1.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	1.9	-1.4	-1.2	-0.6
Past tobacco smoking	1.1	2.0	2.7	1.2	1.6	1.4
Trunk fat-free mass	1.1	6.2	8.4	-2.9	-2.9	-1.4
Noisy workplace	1.1	1.3	2.1	-1.4	-1.4	-0.3
Qualifications: A levels/AS levels or equivalent	1.1	2.4	3.6	1.9	1.7	0.8
Medication: Cholesterol lowering	1.1	1.7	2.3	-1.1	-1.3	-1.5
Medication: Lansoprazole	1.1	1.3	1.6	-1.2	-1.3	0.9
Impedance of arm (left)	1.1	5.3	8.4	2.5	2.9	1.1
Trunk predicted mass	1.1	6.3	8.5	-2.9	-2.9	-1.5
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.2	1.5	1.5	0.1
Birth weight	1.1	2.5	3.1	-1.5	-1.4	-1.8
Migraine (self-reported)	1.1	1.4	2.0	-1.4	-1.4	-0.5
Suffer from ‘nerves’	1.1	1.7	2.1	-1.4	-1.5	1.1
Alcohol drinker status: Previous	1.1	1.3	2.5	0.8	0.9	1.6
Ovarian Cancer	1.0	1.4	3.7	0.6	0.0	-1.9
Angina	1.0	1.3	1.7	-1.1	-1.0	1.3
Age when periods started (menarche)	1.0	2.3	3.0	-1.3	-1.7	1.5
Pain all over the body in last month	1.0	1.0	2.8	0.6	0.2	-1.7
Happiness	1.0	1.2	1.4	-1.2	-1.1	0.9
Comparative height size at age 10	1.0	5.4	8.5	-2.9	-2.7	-0.7
Smoking status: Current	1.0	1.6	2.9	-1.0	-1.7	0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.7	-0.1	-0.2	-1.9
Arm fat-free mass (left)	1.0	5.2	7.4	-2.6	-2.7	-1.2
Impedance of whole body	1.0	4.9	8.0	2.5	2.8	0.6
Intelligence (Savage-Jansen 2018)	0.9	2.7	4.4	2.1	1.9	-0.2
Major Depression (MDD)	0.9	1.1	1.6	-1.3	-0.5	1.2
Schizophrenia (2014)	0.9	2.0	2.9	-1.7	-1.3	1.1
Townsend deprivation index at recruitment	0.9	1.2	2.5	1.6	0.8	-0.8
Current tobacco smoking	0.9	1.5	2.2	-0.8	-1.5	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.7	-0.5	-0.9	-1.6
Chronic bronchitis/emphysema (father)	0.9	1.0	2.7	0.4	0.3	1.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	-0.4	-0.9	1.5
Pulse wave Arterial Stiffness index	0.9	1.0	1.3	1.1	0.9	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	1.9	-0.8	-0.9	1.4
Age at first live birth	0.9	1.6	4.4	-0.6	-0.1	-2.1
Pulse wave peak to peak time	0.9	1.1	1.4	-1.2	-1.0	0.9
Shortness of breath walking on level ground	0.9	1.1	1.2	-0.9	-1.1	-1.1
Smoking status: Previous	0.9	1.4	3.7	-0.4	-0.6	-1.9
Whole body fat-free mass	0.9	5.2	7.2	-2.6	-2.7	-1.1
Ever depressed for a whole week	0.9	1.1	1.6	-1.2	-1.2	0.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.6	-0.5	-1.3	-1.2
Basal cell carcinoma (self-reported)	0.9	1.1	2.0	-1.1	-1.4	-0.4
Body Mass Index (BMI) (2010)	0.8	1.1	2.0	0.6	0.9	-1.4
Hypothyroidism (self reported)	0.8	1.8	2.5	1.4	1.0	-1.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.0	-1.0	-0.9	0.9
Supplements: Zinc	0.8	0.9	1.7	-0.9	-1.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	3.2	1.8	1.5	0.3
Multivitamins +/- minerals	0.8	1.1	1.6	0.4	1.3	-1.2
Illnesses of siblings	0.8	1.1	2.0	1.2	1.4	-0.2
Worrier / anxious feelings	0.8	1.5	4.6	0.1	0.1	-2.1
Medication for pain relief, constipation, heartburn	0.8	1.3	2.1	1.4	1.3	-0.3
Neck or shoulder pain in last month	0.8	1.1	1.4	-1.0	-1.2	0.9
Angina (self-reported)	0.8	1.0	1.9	-0.8	-0.7	1.4
Medication: Omeprazole	0.8	1.0	2.9	-0.0	-0.3	-1.7
Average weekly red wine intake	0.8	1.2	1.7	1.2	1.3	-0.7
Friendships satisfaction	0.8	0.9	2.7	0.0	0.3	1.7
Commuting to job workplace: Walk	0.8	0.9	1.3	-0.7	-0.9	1.1
Whole body water mass	0.8	4.8	6.8	-2.5	-2.6	-1.1
Ever taken oral contraceptive pill	0.8	0.8	1.7	-0.7	-0.5	-1.3
Mother’s age at death	0.8	1.0	3.0	-0.1	0.3	-1.7
Basal metabolic rate	0.8	4.5	6.4	-2.5	-2.5	-1.0
Bipolar Disorder or Schizophrenia	0.7	1.8	3.3	-1.8	-1.2	0.7
Breast Cancer	0.7	1.7	2.9	1.4	1.7	0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.7	-0.7	-0.9	-1.3
Severe depression (siblings)	0.7	0.8	2.3	0.3	0.2	1.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	0.8	1.3	0.4
High blood pressure (mother)	0.7	1.0	1.4	0.9	1.2	0.9
Mouth/teeth dental problems: Dentures	0.7	1.3	1.7	1.1	0.9	1.3
Age at last live birth	0.7	1.0	2.7	-0.6	-0.3	-1.6
Loneliness, isolation	0.7	1.0	1.6	1.3	1.0	-0.5
Long-standing illness, disability or infirmity	0.7	1.1	1.9	-1.1	-1.4	-0.3
Diabetes diagnosed by doctor	0.7	1.2	1.8	-1.3	-1.3	-0.1
Breast cancer (self-reported)	0.7	0.9	1.3	-1.1	-1.1	-0.3
Medication: Aspirin	0.7	0.9	1.3	-1.1	-1.0	0.5
Alzheimer’s Disease (in mother)	0.6	0.7	1.1	-0.8	-0.6	1.1
Triglycerides	0.6	1.0	2.6	0.4	0.6	-1.6
Lung FVC	0.6	2.9	5.3	2.3	1.8	-0.2
Vitamin and mineral supplements	0.6	0.8	2.0	-0.3	-0.7	1.4
Medication: Ramipril	0.6	0.8	2.0	0.3	0.5	1.4
Weight	0.6	2.9	4.2	-2.0	-2.1	-0.8
Length of working week for main job	0.6	0.6	1.7	-0.0	0.3	1.3
Wheeze or whistling in the chest in last year	0.6	1.0	1.6	1.3	0.8	0.9
Medication: Allopurinol	0.6	0.8	1.0	-1.0	-0.8	-0.8
Leg fat-free mass (right)	0.6	3.0	4.7	-2.0	-2.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.1	-1.0	-0.9	0.5
Asthma (self-reported)	0.6	1.2	2.0	1.4	1.3	0.0
Fractured/broken bones in last 5 years	0.6	0.7	1.2	0.6	0.8	-1.1
Mean Putamen Volume	0.5	0.6	1.3	-0.1	0.6	1.1
Blood Eosinophil Count	0.5	3.5	4.5	2.1	1.5	1.9
Systolic Blood Pressure	0.5	2.4	3.2	1.6	1.8	1.2
Hand grip strength (left)	0.5	1.4	1.5	1.1	1.2	-1.2
Number of treatments/medications taken	0.5	0.9	1.5	-1.2	-1.1	-0.2
Systolic blood pressure, automated reading	0.5	1.5	2.9	0.9	0.8	1.7
Impedance of leg (right)	0.5	2.6	4.1	1.7	2.0	-0.8
Leg fat-free mass (left)	0.5	2.5	3.8	-1.9	-2.0	-0.4
Leg predicted mass (left)	0.5	2.4	3.8	-1.9	-1.9	-0.3
Nervous feelings	0.5	1.0	2.2	0.7	0.5	-1.5
Financial difficulties in last 2 years	0.5	0.7	1.1	0.6	1.1	0.7
Time employed in main current job	0.5	0.5	0.9	-0.2	-0.9	0.8
Falls in the last year	0.5	0.7	1.4	-0.4	-0.7	-1.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.9	-0.7	-1.0	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	-0.9	-0.9	0.4
Eye problems/disorders: Cataract	0.5	0.6	0.8	-0.8	-0.5	0.9
Leg predicted mass (right)	0.5	2.9	4.6	-2.0	-2.1	-0.3
Number of self-reported non-cancer illnesses	0.5	0.8	1.5	-0.9	-1.2	-0.5
High cholesterol (Self-reported)	0.5	0.9	1.3	-1.2	-1.1	-0.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.7	0.9	0.6	-0.8
Schizophrenia vs Biploar Disorder	0.4	0.6	0.8	-0.7	-0.9	0.6
Prostate Cancer	0.4	0.6	0.9	-0.3	-0.9	-0.9
Smoking Status	0.4	1.0	1.5	-0.5	-1.1	-1.2
Sensitivity / hurt feelings	0.4	0.8	1.1	-0.5	-1.1	-1.0
Diabetes (father)	0.4	0.5	1.4	0.2	0.1	-1.2
Diabetes (mother)	0.4	0.5	1.2	0.6	0.2	-1.1
Hand grip strength (right)	0.4	1.0	1.7	0.8	0.7	-1.3
Medication: Atenolol	0.4	0.5	1.1	0.6	0.4	1.0
Sitting height	0.4	3.1	4.5	-2.1	-2.0	-0.9
Body mass index (BMI)	0.4	1.7	3.0	-1.4	-1.7	-0.2
Medication: Simvastatin	0.4	0.5	1.6	0.0	0.0	-1.3
Peak expiratory flow (PEF)	0.4	0.8	2.4	0.1	0.2	-1.6
Loud music exposure frequency	0.4	0.4	0.5	-0.7	-0.6	0.6
Medication: Paracetamol	0.4	0.6	1.0	-0.9	-1.0	0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.6	0.4	0.4	1.3
Glaucoma (self-reported)	0.4	0.4	0.6	-0.5	-0.8	0.6
Worry too long after embarrassment	0.4	0.7	1.2	-0.5	-1.1	0.7
Mean time to correctly identify matches	0.4	0.7	1.2	-0.7	-1.1	0.6
Alcohol intake frequency.	0.4	1.0	1.2	1.0	1.1	1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.7	-0.8	-0.9	0.1
Supplements: Vitamin C	0.4	0.4	1.3	0.1	0.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.4	0.8	1.2	-0.4
Back pain experienced in last month	0.4	0.5	1.4	0.2	0.4	1.2
Financial situation satisfaction	0.4	0.4	1.2	0.2	0.2	1.1
Irritability	0.4	0.6	1.4	0.5	0.3	-1.2
Heart disease (siblings)	0.4	0.4	0.5	-0.7	-0.6	0.7
Leg fat mass (left)	0.4	1.5	2.5	-1.3	-1.6	-0.7
Ulcerative Colitis (UC)	0.3	0.5	0.6	0.7	0.6	0.8
Reaction Time	0.3	0.6	1.3	-0.5	-0.6	1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.9	-0.9	-0.8	0.2
Lung FEV1/FVC ratio	0.3	1.7	2.6	-1.3	-1.0	-1.6
Medication: Metformin	0.3	0.4	0.6	-0.7	-0.7	-0.3
Taking other prescription medications	0.3	0.5	1.1	-0.7	-1.0	-0.1
Impedance of leg (left)	0.3	1.5	2.4	1.3	1.5	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.1	1.0	0.9	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	0.5	0.6	0.8
Fluid intelligence score	0.3	0.6	1.0	0.8	1.0	0.5
Asthma	0.3	0.6	0.8	0.9	0.9	0.3
Arm fat mass (right)	0.3	1.2	1.9	-1.2	-1.4	-0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.2	1.1	0.6	-0.7
Medication: Ibuprofen	0.3	0.3	0.7	-0.5	-0.1	0.9
Medication: Seretide 50 evohaler	0.3	0.3	0.7	0.8	0.6	0.1
Leg fat mass (right)	0.3	1.2	1.8	-1.0	-1.4	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	-0.2	-0.6	-0.8
Qualifications: nursing, teaching	0.3	0.5	0.7	0.7	0.6	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.9	0.6	0.3	-0.9
Arm fat mass (left)	0.3	1.4	2.4	-1.3	-1.5	-0.4
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	-0.5	-0.7	-0.3
Medication: Paracetamol	0.3	0.5	0.7	-0.6	-0.7	0.8
Commuting to job workplace: Cycle	0.3	0.4	0.8	0.2	0.5	-0.9
Depression (Nagel 2018)	0.2	0.2	0.7	-0.1	-0.0	-0.8
Neuroticism (Nagel 2018)	0.2	0.5	0.8	0.9	0.8	-0.3
Crohns Disease (2012)	0.2	0.4	0.9	0.3	-0.4	-0.9
Neuroticism (2016)	0.2	0.3	0.5	0.4	0.4	-0.7
Ulcerative Colitis	0.2	0.3	0.4	0.6	0.7	0.1
Blood Platelet Count	0.2	2.0	5.4	-0.6	-0.4	2.3
Allergy or Eczema	0.2	0.4	1.2	0.3	0.2	1.1
Neuroticism	0.2	0.6	1.0	1.0	0.8	0.2
Chronotype (morning person)	0.2	0.5	0.7	-0.6	-0.9	-0.7
Tanning	0.2	2.7	3.8	-1.8	-2.0	1.0
Medication: Co-codamol	0.2	0.2	0.6	0.4	-0.1	0.8
Average weekly fortified wine intake	0.2	0.3	0.4	0.7	0.2	-0.5
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.3	-0.6	0.3
Trunk fat mass	0.2	0.7	1.1	-0.8	-1.1	-0.5
Waist circumference	0.2	0.6	1.0	-0.9	-1.0	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.6	-0.7	-0.8	-0.1
Alcohol intake versus 10 years previously	0.2	0.3	0.7	0.2	0.1	-0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.9	0.2	0.3	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.2	0.2	0.2	-1.5
Standing height	0.2	1.9	2.3	-1.5	-1.1	-1.5
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.6	-0.5	-0.0
Birth weight of first child	0.2	0.3	0.8	0.3	-0.2	-0.9
Exposure to tobacco smoke outside home	0.2	0.3	0.5	-0.7	-0.6	-0.2
Number of full brothers	0.2	0.2	0.4	0.0	-0.5	0.6
Health satisfaction	0.2	0.2	0.4	-0.3	-0.3	0.6
Heart disease (mother)	0.2	0.2	0.3	0.3	0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.4	0.1	0.7
Whole body fat mass	0.2	0.7	1.1	-0.8	-1.1	-0.5
Had major operations	0.2	0.2	0.5	0.1	-0.7	0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	0.7	0.5	0.1
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.3	0.3	-0.7
Guilty feelings	0.2	0.3	0.6	0.5	0.2	-0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.1	0.4	-0.7
Average weekly beer plus cider intake	0.2	0.3	0.5	0.4	0.4	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.8	0.5	0.1
Pack years of smoking	0.2	0.4	0.5	0.7	0.4	0.6
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.2	0.1	0.5
Crohns Disease (2017)	0.1	0.2	0.4	0.5	-0.2	-0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.7	0.3	-0.1
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.2	-0.2	-0.6
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.1	0.3	0.6
Lupus	0.1	0.2	0.4	0.6	0.1	0.3
Height	0.1	2.6	3.9	-1.4	-1.4	-2.0
Respiratory disease	0.1	0.1	0.2	0.4	0.4	0.3
Hair Pigment	0.1	4.1	11.2	-0.7	-0.7	3.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.1	-0.1	-0.5
Medication for hormone replacement therapy	0.1	0.1	0.1	0.2	0.3	-0.4
Pack years adult smoking proportion	0.1	0.2	0.4	0.4	0.3	0.6
Maternal smoking around birth	0.1	0.2	0.5	-0.7	-0.3	0.1
Fed-up feelings	0.1	0.1	0.2	0.3	0.1	-0.5
Relative age voice broke	0.1	0.2	0.4	0.3	0.3	0.7
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.4	-0.3	0.1
Alcohol usually taken with meals	0.1	0.1	0.2	-0.3	-0.0	-0.5
Allergy	0.1	0.2	0.2	-0.5	-0.4	0.5
Hip circumference	0.1	0.5	0.8	-0.9	-0.9	0.2
Father’s age at death	0.1	0.2	0.3	0.1	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.4	-0.1	-0.1	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.2	0.4	0.2
Illnesses of mother	0.1	0.2	0.2	-0.4	-0.3	-0.5
Tense / ‘highly strung’	0.1	0.1	0.2	0.1	0.1	-0.5
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	0.7	0.6	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.1	0.4	0.0	0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	1.0	0.1	-0.0	-1.0
Leg fat percentage (right)	0.1	0.3	1.0	0.1	-0.2	-1.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.4	0.2	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.4	-0.1	0.2
Overall health rating	0.1	0.3	0.4	-0.2	-0.6	-0.7
Chest pain or discomfort	0.1	0.1	0.3	0.1	-0.2	-0.5
Family relationship satisfaction	0.1	0.1	0.1	0.1	-0.3	-0.3
Knee pain experienced in last month	0.1	0.1	0.4	0.6	0.3	0.0
Illnesses of father: Heart disease	0.1	0.2	0.3	-0.1	-0.3	0.6
Mood swings	0.1	0.2	0.5	-0.4	-0.7	-0.0
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.5	0.5	0.2
Medication: Blood pressure	0.1	0.1	0.2	0.4	0.3	0.2
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.3	-0.2	0.4
Leg fat percentage (left)	0.1	0.3	0.6	-0.2	-0.6	-0.8
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.6	0.7	0.8	0.1
Cholesterol lowering medication	0.1	0.1	0.3	-0.1	0.1	0.6
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	-0.3	-0.3	0.1
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	0.1	0.1	-0.0
Worry (Nagel 2018)	0.0	0.1	0.1	0.3	0.4	0.1
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.2	-0.2	0.0
Blood Red Count	0.0	0.2	0.4	0.1	0.6	0.4
Blood White Count	0.0	0.3	0.6	0.6	-0.1	-0.8
Heel T-Score	0.0	0.1	0.3	0.2	0.3	-0.6
BMI	0.0	0.1	0.3	-0.3	-0.5	0.1
Waist Hip Ratio (WHR)	0.0	0.1	0.2	-0.5	-0.1	0.3
Cardiovascular Disease	0.0	0.1	0.2	-0.5	-0.2	0.4
Average weekly spirits intake	0.0	0.0	0.1	-0.2	-0.2	0.2
Relative age of first facial hair	0.0	0.1	0.1	-0.2	0.4	0.1
Trunk fat percentage	0.0	0.0	0.1	-0.0	-0.3	-0.1
High blood pressure	0.0	0.1	0.2	-0.4	-0.4	-0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.3	0.2	0.1
Forced vital capacity (FVC)	0.0	0.2	0.5	0.1	-0.2	-0.7
Qualifications: None of the above	0.0	0.1	0.2	0.4	-0.1	-0.0
Mouth/teeth dental problems	0.0	0.0	0.1	-0.3	0.2	-0.0
Heart attack	0.0	0.0	0.1	-0.3	-0.2	0.0
Neuroticism score	0.0	0.0	0.1	0.3	-0.2	-0.2
Arm fat percentage (right)	0.0	0.0	0.0	0.0	-0.1	0.2
Number of live births	0.0	0.1	0.1	0.2	0.3	-0.1
Headache pain in last month	0.0	0.0	0.1	0.2	0.1	-0.3
Body fat percentage	0.0	0.0	0.0	0.1	-0.2	-0.2
Comparative body size at age 10	0.0	0.0	0.0	0.0	-0.2	0.1
Qualifications: College or University degree	0.0	0.1	0.4	-0.2	0.1	-0.6
Medication: Blood pressure	0.0	0.0	0.1	-0.2	-0.1	-0.3
Hypertension (Self-reported)	0.0	0.1	0.1	-0.3	-0.3	0.0
Arm fat percentage (left)	0.0	0.0	0.1	-0.1	-0.3	0.2
Medication for cholesterol	0.0	0.1	0.1	-0.3	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	-0.3	-0.1	-0.0
Miserableness	0.0	0.0	0.1	0.2	-0.1	-0.2
Pain experienced in last month	0.0	0.0	0.1	-0.1	0.2	0.2

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