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chr5:136,262,454-139,475,611

Best TWAS P=3.86e-30 · Best GWAS P=3.86e-30 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Artery Tibial	RP11-381K20.5	0.09	0.09	lasso	1	0.06	8.4e-06	-11.4	11.4	3.9e-30	-1.00	0.00	1.00	TRUE
10	GTEx	Heart Left Ventricle	REEP2	0.14	0.05	lasso	2	0.04	2.9e-03	-11.4	11.1	1.4e-28	-0.87	0.00	0.93	TRUE
16	GTEx	Testis	HNRNPA0	0.10	0.01	enet	18	0.01	9.4e-02	-9.9	8.2	2.1e-16	-0.47	0.12	0.12	TRUE
18	METSIM	Adipose	REEP2	0.36	0.15	enet	32	0.15	4.2e-22	5.4	7.6	4.1e-14	-0.16	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	REEP2	0.06	0.05	lasso	5	0.05	1.8e-06	-6.0	6.8	7.8e-12	-0.27	0.93	0.00	TRUE
11	GTEx	Nerve Tibial	REEP2	0.16	0.08	lasso	11	0.10	2.5e-07	5.6	6.3	2.4e-10	-0.23	0.96	0.01	TRUE
6	GTEx	Colon Sigmoid	MYOT	0.16	-0.01	enet	22	0.01	1.9e-01	1.9	-5.6	2.0e-08	0.25	0.05	0.05	TRUE
26	The Cancer Genome Atlas	Thyroid Carcinoma	CDC25C	0.03	0.01	lasso	8	0.02	6.5e-03	-2.8	5.6	2.2e-08	-0.23	0.04	0.26	TRUE
5	GTEx	Brain Hypothalamus	RP11-381K20.5	0.37	-0.01	enet	29	0.10	2.7e-03	-11.4	5.4	5.6e-08	-0.65	0.01	0.80	TRUE
7	GTEx	Esophagus Gastroesophageal Junction	DNAJC18	0.17	0.01	lasso	10	0.04	2.0e-02	-4.0	-5.1	2.7e-07	-0.12	0.03	0.46	TRUE
19	METSIM	Adipose	RP11-381K20.5	0.05	0.06	lasso	4	0.05	3.1e-08	-11.3	11.4	4.7e-30	-1.00	0.00	1.00	FALSE
12	GTEx	Nerve Tibial	RP11-381K20.5	0.10	0.08	lasso	3	0.09	1.1e-06	-11.3	10.6	3.6e-26	-0.97	0.00	0.99	FALSE
17	GTEx	Testis	RP11-381K20.5	0.16	0.05	lasso	5	0.03	1.5e-02	7.4	10.5	6.7e-26	-0.56	0.06	0.70	FALSE
14	GTEx	Skin Sun Exposed Lower leg	RP11-381K20.5	0.07	0.04	lasso	2	0.03	9.7e-04	-10.5	10.5	7.8e-26	-0.90	0.01	0.96	FALSE
15	GTEx	Testis	CDC23	0.10	0.07	enet	10	0.07	6.1e-04	-10.3	-10.0	1.6e-23	0.56	0.57	0.07	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	KDM3B	0.07	0.01	blup	307	0.03	1.0e-04	4.1	-9.5	2.0e-21	0.64	0.06	0.90	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDC25C	0.03	0.03	blup	43	0.03	1.7e-04	-7.6	8.4	5.2e-17	-0.42	0.05	0.69	FALSE
4	GTEx	Brain Cerebellum	KLHL3	0.14	0.04	enet	19	0.08	2.8e-03	-6.8	-8.4	6.1e-17	0.69	0.03	0.81	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIF20A	0.01	0.00	blup	27	0.01	1.4e-02	-9.1	7.9	3.1e-15	-0.46	0.01	0.57	FALSE
20	NTR	Blood	KLHL3	0.02	0.01	bslmm	437	0.01	1.9e-04	1.3	-7.8	7.4e-15	0.47	0.10	0.57	FALSE
8	GTEx	Esophagus Muscularis	REEP2	0.13	0.11	enet	13	0.12	1.2e-07	5.6	7.4	1.6e-13	-0.27	0.90	0.00	FALSE
22	YFS	Blood	CDC23	0.01	0.01	lasso	2	0.01	3.1e-03	-8.6	7.0	1.8e-12	-0.36	0.33	0.04	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	GFRA3	0.02	0.01	lasso	2	0.01	2.2e-02	3.7	-6.0	1.6e-09	0.38	0.03	0.61	FALSE
9	GTEx	Heart Atrial Appendage	REEP2	0.24	0.15	lasso	6	0.13	2.0e-06	5.6	5.6	1.7e-08	-0.14	0.77	0.06	FALSE
2	GTEx	Artery Aorta	REEP2	0.12	0.02	lasso	6	0.02	3.0e-02	5.6	5.6	2.8e-08	-0.18	0.29	0.05	FALSE
13	GTEx	Ovary	REEP2	0.19	0.10	enet	5	0.14	2.5e-04	-6.0	5.4	5.4e-08	-0.29	0.06	0.35	FALSE