Hub : Genes

HNRNPA0

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.0990 0.0450 0.0031 0.011 NA 0.012 NA 0.007 0.10 NA 0.09400 NA 0.160
2 YFS Blood 0.0346 0.0161 0.0015 0.000 0.004 0.010 0.005 0.003 0.32 0.012 0.00023 0.0073 0.024

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.5 3.9 7.8 2.8 -0.2
Bipolar Disorder or Schizophrenia 1.9 4.6 8.2 2.9 1.0
Depressed Affect (Nagel 2018) 0.8 1.6 3.2 -1.8 0.0
Depression (Nagel 2018) 0.1 0.1 0.2 -0.5 0.2
Intelligence (Savage-Jansen 2018) 1.7 5.1 9.6 3.1 -0.8
Neuroticism (Nagel 2018) 0.2 0.4 0.5 -0.7 0.6
Schizophrenia (2018) 0.9 2.0 2.1 1.4 1.4
Schizophrenia vs Biploar Disorder 1.2 1.5 1.7 -1.3 1.2
Worry (Nagel 2018) 0.1 0.3 0.4 0.4 0.6
Alzheimer’s Disease (in mother) 0.2 0.2 0.3 0.5 -0.3
Alzheimer’s Disease (in father) 3.3 3.5 4.8 -2.2 1.5
Alzheimer’s Disease (including proxy) 0.0 0.1 0.1 -0.3 0.3
Crohns Disease (2017) 1.7 3.7 5.5 -2.3 1.4
Irritable Bowel Disease (IBD) 1.2 3.0 4.5 -2.1 1.2
Ulcerative Colitis (UC) 0.4 0.8 1.3 -1.1 0.5
Major Depression (MDD) 0.3 0.3 0.6 -0.3 0.7
Reaction Time 0.1 0.1 0.2 -0.4 0.3
Verbal and Numeric Reasoning (VNR) 2.3 5.6 11.0 3.3 -0.4
Breast Cancer 0.3 0.8 0.9 1.0 -0.8
Ovarian Cancer 0.7 1.0 1.4 1.2 -0.8
Prostate Cancer 1.9 2.7 4.2 -1.1 2.1
Age at First Birth 0.2 0.3 0.5 0.7 0.4
Bipolar Disorder (2011) 0.4 0.4 0.7 0.8 -0.4
Body Mass Index (BMI) (2010) 0.5 0.7 1.4 0.0 -1.2
Coronary Artery Disease (CAD) 0.8 1.0 1.6 -1.2 -0.7
Crohns Disease (2012) 2.1 3.4 3.6 -1.9 1.8
Mean Putamen Volume 0.3 0.3 0.3 0.5 0.6
Fasting Glucose 0.5 0.6 1.2 0.1 -1.1
HbA1C 1.4 1.5 2.0 1.0 1.4
HDL Cholesterol 1.4 2.3 4.6 2.1 -0.1
LDL Cholesterol 0.0 0.0 0.1 -0.3 -0.1
Lupus 0.6 0.9 0.9 -0.9 -0.9
Neuroticism (2016) 0.2 0.3 0.4 -0.5 -0.7
Primary Biliary Cirrhosis 1.4 2.1 4.1 2.0 -0.2
Rheumatoid Arthritis 2.8 3.8 6.1 -2.5 1.2
Schizophrenia (2014) 1.5 3.4 4.9 2.2 1.4
Triglycerides 0.3 0.5 0.8 0.3 -0.9
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.1 -0.3 -0.2
Ulcerative Colitis 0.6 0.8 1.3 -0.6 1.1
Blood Eosinophil Count 0.2 1.4 2.8 -1.7 -0.4
Blood Platelet Count 0.6 6.5 10.0 3.2 -1.7
Blood Red Count 1.0 9.2 18.5 -4.3 -0.0
Blood White Count 0.3 2.4 4.6 -2.1 -0.4
Heel T-Score 0.3 2.1 4.2 -0.1 2.0
BMI 1.2 6.9 9.1 -2.2 -3.0
Height 0.2 3.0 3.2 1.7 1.8
Waist Hip Ratio (WHR) 0.1 0.6 0.9 0.6 1.0
Systolic Blood Pressure 0.7 3.7 6.7 2.6 -0.9
Smoking Status 1.6 3.9 6.4 -2.5 -1.2
Allergy or Eczema 1.3 3.4 6.6 -2.6 -0.5
Cardiovascular Disease 0.4 1.2 2.3 0.1 -1.5
Hypothyroidism (self reported) 1.3 2.9 3.1 -1.8 1.7
Respiratory disease 0.5 1.2 2.4 -1.5 0.3
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.4 -1.6 0.5
Lung FEV1/FVC ratio 0.3 1.8 3.2 1.8 -0.5
Lung FVC 0.7 3.8 3.8 2.0 1.9
Neuroticism 0.4 1.0 2.0 -1.4 -0.2
Chronotype (morning person) 0.4 0.9 1.8 1.4 0.1
Hair Pigment 0.1 2.2 4.1 2.0 0.5
Tanning 0.0 0.0 0.0 -0.0 0.1
Hand grip strength (left) 0.9 2.5 3.9 2.0 -1.0
Number of treatments/medications taken 3.3 6.0 11.9 -3.4 -0.2
Average weekly spirits intake 0.3 0.3 0.5 0.7 -0.4
Sensitivity / hurt feelings 0.6 1.1 1.1 -1.1 1.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.4 0.1 -1.2
Hearing difficulty/problems: Yes 0.0 0.0 0.0 -0.2 -0.2
Relative age of first facial hair 0.6 1.2 1.4 1.2 1.0
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 4.2 -0.5 2.0
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 -0.1 0.5
Ever had hysterectomy (womb removed) 0.0 0.0 0.1 -0.1 0.3
Systolic blood pressure, automated reading 0.4 1.2 1.4 1.2 -1.1
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 -0.1 0.1
Angina 0.5 0.7 1.3 -1.1 -0.3
Medication for hormone replacement therapy 0.5 0.6 1.1 0.2 -1.0
Vitamin and mineral supplements 2.6 3.5 6.2 -2.5 0.9
Supplements: Zinc 2.4 2.6 5.1 2.3 0.4
Medication: Co-codamol 0.7 0.9 1.3 -1.1 0.6
Medication: Metformin 1.0 1.4 1.6 -1.1 1.3
Diabetes (father) 0.0 0.0 0.0 -0.2 -0.2
Diabetes (mother) 0.2 0.3 0.6 -0.8 -0.1
Severe depression (siblings) 1.2 1.4 2.5 1.6 -0.5
Pack years adult smoking proportion 0.6 1.0 1.0 -1.0 -1.0
Impedance of leg (right) 0.2 1.2 1.5 1.2 0.9
Leg fat-free mass (left) 0.4 2.3 3.8 -0.9 -1.9
Trunk fat percentage 0.8 3.1 4.0 -1.5 -2.0
Hand grip strength (right) 1.3 3.7 5.7 2.4 -1.3
Townsend deprivation index at recruitment 0.4 0.6 0.7 -0.6 -0.8
Current tobacco smoking 0.4 0.7 1.3 -0.2 -1.1
Average weekly fortified wine intake 1.1 1.3 1.6 -1.1 1.2
Maternal smoking around birth 1.1 1.5 2.8 -1.7 0.6
Fed-up feelings 1.0 1.8 2.1 -1.5 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.5 -0.7 -0.1
Relative age voice broke 0.8 1.2 1.7 0.9 1.3
Taking other prescription medications 1.9 3.0 5.9 -2.4 0.2
Age when periods started (menarche) 0.4 1.0 1.6 1.3 0.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.3 -0.6 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.7 7.1 -0.5 2.7
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 2.0 0.3 -1.4
Qualifications: CSEs or equivalent 2.8 3.7 5.7 -2.4 -1.3
Serious illness, injury or assault to yourself 0.6 0.7 1.4 1.2 0.2
High blood pressure 0.3 0.8 1.4 -1.2 -0.5
Hayfever, allergic rhinitis or eczema 1.3 2.9 5.4 -2.3 -0.6
Multivitamins +/- minerals 1.4 1.8 2.7 1.6 -0.9
Stomach or abdominal pain in last month 3.4 4.2 6.3 2.5 -1.4
Supplements: Glucosamine 0.2 0.2 0.3 -0.6 -0.4
Diverticular disease/diverticulitis (self-reported) 2.0 2.4 3.0 -1.3 1.7
Medication: Atenolol 0.0 0.0 0.1 0.2 -0.2
Medication: Levothyroxine sodium 1.7 3.0 3.5 -1.9 1.5
Sitting height 0.1 0.9 1.2 1.1 -0.7
Chronic bronchitis/emphysema (father) 0.2 0.3 0.6 -0.1 0.8
High blood pressure (mother) 0.1 0.1 0.2 0.4 -0.3
Body mass index (BMI) 1.6 6.7 8.6 -2.9 -2.2
Impedance of leg (left) 0.3 1.7 2.6 1.6 0.8
Leg predicted mass (left) 0.4 2.2 3.7 -0.9 -1.9
Trunk fat mass 0.9 3.7 4.8 -1.6 -2.2
Waist circumference 1.2 4.5 7.9 -2.8 -1.1
Number of incorrect matches in round 4.6 7.6 9.4 -2.4 3.1
Past tobacco smoking 1.8 3.2 6.3 2.5 -0.4
Alcohol usually taken with meals 1.0 1.7 3.3 1.8 0.2
Nervous feelings 0.2 0.3 0.5 -0.5 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.9 1.3 -0.7 1.1
Hearing difficulty/problems with background noise 2.0 3.3 6.4 -2.5 0.3
Hair/balding pattern: Pattern 2 1.1 1.4 2.7 -0.2 -1.6
Had menopause 0.3 0.3 0.4 0.5 -0.6
Had other major operations 0.6 0.7 1.4 -0.2 -1.2
Forced vital capacity (FVC) 1.6 6.0 11.9 3.5 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 3.7 -0.5 1.9
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 4.6 -0.2 -2.1
Qualifications: None of the above 3.0 6.5 12.8 -3.6 -0.4
Financial difficulties in last 2 years 0.2 0.2 0.4 0.6 -0.3
Mouth/teeth dental problems 1.1 1.6 1.7 1.3 -1.3
Heart attack 0.9 1.2 2.3 -1.5 0.3
Allergy 0.6 1.4 2.8 1.7 0.2
Pain all over the body in last month 1.2 1.3 1.6 -1.3 1.0
Diabetes (self-reported) 1.2 1.9 2.3 -1.5 1.2
Hayfever/allergic rhinitis (self-reported) 2.0 2.7 4.3 -2.1 1.1
Medication: Ramipril 1.1 1.4 2.7 -1.6 -0.2
Medication: Simvastatin 1.1 1.5 3.1 -1.8 0.0
Fluid intelligence score 1.8 3.7 7.0 2.6 0.7
Illnesses of siblings 1.1 1.5 1.6 1.2 1.3
Neuroticism score 0.2 0.4 0.7 -0.8 0.2
Weight 0.7 3.5 3.5 -1.9 -1.9
Impedance of arm (right) 0.7 3.5 5.5 2.3 1.2
Arm fat percentage (right) 1.1 4.3 4.6 -2.1 -2.0
Trunk fat-free mass 0.1 0.8 1.0 -0.8 -1.0
Hip circumference 1.1 4.9 5.9 -2.4 -1.9
Time employed in main current job 1.2 1.4 1.5 -1.1 1.2
Alcohol intake versus 10 years previously 0.3 0.4 0.6 -0.8 -0.4
Father’s age at death 1.1 1.4 2.4 1.5 -0.7
Worrier / anxious feelings 0.5 0.9 0.9 -1.0 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 1.4 -0.2 1.2
Falls in the last year 0.5 0.6 0.8 -0.7 -0.9
Hair/balding pattern: Pattern 3 0.2 0.3 0.5 -0.7 0.1
Number of live births 0.2 0.3 0.3 -0.6 0.4
Forced expiratory volume in 1-second (FEV1) 1.8 6.1 12.2 3.5 -0.3
Pulse rate 6.3 10.6 15.6 4.0 -2.4
Happiness 2.5 3.0 5.4 -2.3 -0.7
Noisy workplace 0.3 0.3 0.6 -0.7 0.4
Qualifications: A levels/AS levels or equivalent 0.9 2.1 4.0 2.0 0.3
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 2.5 1.6 0.2
Mouth/teeth dental problems: Dentures 7.3 12.3 14.7 -3.8 3.1
Asthma 0.2 0.4 0.7 -0.8 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.7 -0.0 0.9
Medication: Cholesterol lowering 0.0 0.0 0.0 0.1 -0.2
Depression (self-reported) 0.0 0.0 0.0 0.2 0.2
Medication: Lansoprazole 1.7 2.0 3.9 -2.0 0.2
Prospective memory result 0.0 0.0 0.0 0.2 -0.1
Lung cancer (father) 0.1 0.1 0.3 -0.5 -0.0
Illnesses of mother 1.7 2.1 4.1 2.0 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.7 4.2 2.0 1.1
Pulse wave Arterial Stiffness index 0.2 0.3 0.4 -0.4 0.6
Impedance of arm (left) 0.7 3.4 4.9 2.2 1.4
Arm fat mass (right) 1.3 5.2 5.6 -2.2 -2.4
Trunk predicted mass 0.1 0.7 1.0 -0.7 -1.0
Standing height 0.3 2.6 5.3 2.3 0.2
Length of working week for main job 1.3 1.5 2.0 1.0 -1.4
Exposure to tobacco smoke at home 1.1 1.3 2.2 0.5 1.5
Breastfed as a baby 0.6 0.7 0.9 -0.9 0.8
Tense / ‘highly strung’ 0.4 0.6 1.0 0.5 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.0 -0.0 0.2
Hair/balding pattern: Pattern 4 0.3 0.8 1.4 -1.2 0.4
Birth weight of first child 0.5 0.9 1.2 1.1 0.8
Peak expiratory flow (PEF) 0.6 1.5 2.9 1.7 0.2
Pulse wave reflection index 4.1 5.1 6.9 -2.6 1.8
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 0.0 -0.5
Loud music exposure frequency 0.2 0.3 0.4 -0.6 -0.4
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 5.0 2.2 -0.4
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.2 0.5 -1.1
Blood clot in the leg (DVT) 0.5 0.7 1.1 -1.1 0.5
Medication: Paracetamol 2.2 3.7 4.7 -2.2 1.6
Headache pain in last month 0.6 1.0 1.1 1.0 0.9
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.1 -0.1 0.4
Glaucoma (self-reported) 0.7 0.8 1.6 -0.3 1.2
Gout (self-reported) 0.6 0.8 1.4 1.2 0.5
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 2.3 -1.5 1.5
Medication: Amlodipine 1.3 1.9 3.7 0.1 -1.9
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.1 -1.1 0.8
Birth weight 0.0 0.0 0.1 0.2 0.0
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.6 0.8 -0.5
High blood pressure (siblings) 1.2 1.7 3.2 -0.4 -1.8
Forced vital capacity (FVC), Best measure 0.7 2.6 2.9 1.7 1.5
Body fat percentage 1.1 4.4 4.5 -2.1 -2.1
Leg fat percentage (right) 2.1 7.5 9.8 -3.1 -2.3
Arm fat-free mass (right) 0.4 2.1 2.8 -1.2 -1.7
Exposure to tobacco smoke outside home 0.9 1.2 1.4 1.2 -1.0
Comparative body size at age 10 0.6 1.6 2.5 0.8 -1.6
Number of full brothers 0.1 0.1 0.1 -0.3 -0.4
Worry too long after embarrassment 0.0 0.0 0.0 0.2 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.8 -0.3 0.9
Wheeze or whistling in the chest in last year 1.8 3.3 3.7 -1.7 -1.9
Number of children fathered 2.2 2.5 5.0 -2.2 0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.3 0.2 1.5
Age at first live birth 0.8 1.4 2.8 1.7 -0.3
Pulse wave peak to peak time 0.3 0.3 0.4 0.6 -0.5
Health satisfaction 2.9 3.8 7.2 -2.7 -0.6
Shortness of breath walking on level ground 0.3 0.4 0.8 0.2 -0.9
Qualifications: College or University degree 1.5 4.8 4.9 2.2 2.2
Eye problems/disorders: None of the above 0.2 0.3 0.4 0.3 -0.7
Mouth/teeth dental problems: Loose teeth 0.9 1.0 1.9 -0.4 1.4
Emphysema/chronic bronchitis 0.4 0.4 0.9 0.1 -0.9
Medication for pain relief, constipation, heartburn 1.2 2.1 4.2 2.0 -0.1
Neck or shoulder pain in last month 0.3 0.4 0.6 0.8 0.4
Medication: Blood pressure 0.1 0.2 0.2 -0.4 -0.5
Angina (self-reported) 0.4 0.5 1.0 -1.0 -0.2
Migraine (self-reported) 1.7 2.1 4.2 2.1 0.0
Medication: Ibuprofen 0.2 0.3 0.4 -0.3 0.7
Medication: Allopurinol 0.5 0.7 1.4 1.2 0.1
Medication: Omeprazole 0.8 1.0 1.1 -0.9 -1.0
Medication: Seretide 50 evohaler 0.3 0.4 0.6 -0.4 -0.8
Mean time to correctly identify matches 0.4 0.7 0.9 -0.9 0.8
Heart disease (mother) 1.2 1.5 1.9 -1.4 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.2 3.9 -0.8 -2.0
Whole body fat mass 1.2 4.9 5.5 -2.1 -2.3
Leg fat mass (right) 1.7 6.5 6.6 -2.6 -2.5
Arm predicted mass (right) 0.3 1.8 2.2 -1.2 -1.5
Pulse rate, automated reading 11.7 37.7 67.5 8.2 -2.8
Alcohol intake frequency. 0.3 0.6 1.2 -0.0 -1.1
Comparative height size at age 10 0.0 0.2 0.3 0.3 0.6
Number of full sisters 0.2 0.2 0.2 0.4 0.5
Suffer from ‘nerves’ 0.1 0.2 0.3 -0.3 -0.6
Overall health rating 1.8 3.9 7.8 -2.8 -0.3
Chest pain or discomfort 0.1 0.1 0.3 -0.1 0.5
Had major operations 0.1 0.1 0.2 -0.1 0.5
Age at last live birth 0.9 1.3 1.6 1.3 -1.0
Family relationship satisfaction 1.1 1.3 2.4 -1.5 0.5
Leg pain on walking 2.2 2.7 5.1 -2.2 0.6
Qualifications: NVQ or HND or HNC or equivalent 2.2 2.7 5.4 -0.2 -2.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.0 -0.7 1.0
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.2 -1.1 -0.5
Medication: Aspirin 0.0 0.1 0.1 -0.3 -0.0
Supplements: Vitamin C 4.1 4.8 9.5 3.1 -0.3
Knee pain experienced in last month 0.6 1.0 1.5 -1.2 -0.7
Hypertension (Self-reported) 0.3 0.8 1.5 -1.2 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.7 1.9 -1.2 -1.4
Illnesses of father: Heart disease 0.0 0.0 0.0 0.1 0.1
Illnesses of siblings: Diabetes 0.2 0.2 0.4 -0.6 0.3
Smoking status: Previous 1.5 2.2 4.4 -2.1 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 -0.1 0.4
Whole body fat-free mass 0.2 1.4 2.2 -0.7 -1.5
Leg fat-free mass (right) 0.3 1.8 3.3 -0.4 -1.8
Arm fat percentage (left) 1.2 4.8 5.8 -2.4 -2.0
Average weekly red wine intake 0.2 0.3 0.5 0.7 0.3
Handedness (chirality/laterality): Left-handed 1.7 2.0 3.0 1.0 1.7
Mood swings 0.0 0.0 0.0 0.1 0.2
Loneliness, isolation 0.5 0.7 1.3 -1.1 0.3
Long-standing illness, disability or infirmity 2.1 3.3 6.2 -2.5 0.6
Ever had bowel cancer screening 0.7 0.8 1.2 -1.1 0.6
Diabetes diagnosed by doctor 1.2 2.0 2.3 -1.5 1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 0.5 0.1 -0.7
Friendships satisfaction 1.4 1.7 2.9 -1.7 0.8
Qualifications: nursing, teaching 0.9 1.3 2.6 1.6 -0.3
Commuting to job workplace: Walk 0.3 0.3 0.5 0.1 -0.7
Eye problems/disorders: Cataract 2.8 3.3 3.5 -1.9 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.5 0.5 -0.7
Medication for cholesterol 3.4 5.1 9.5 3.1 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.0 -0.8 1.4
Back pain experienced in last month 0.4 0.6 1.0 -0.5 -1.0
Mineral and other dietary supplements 0.3 0.4 0.8 0.9 -0.0
Breast cancer (self-reported) 1.0 1.2 1.8 0.8 1.3
Asthma (self-reported) 0.4 0.7 1.4 -1.2 -0.2
Osteoporosis (self-reported) 0.4 0.5 0.9 -0.9 0.3
Osteoarthritis (self-reported) 0.6 0.8 1.6 -1.2 0.3
Medication: Aspirin 0.1 0.1 0.1 -0.4 0.1
Medication: Gliclazide 0.1 0.1 0.1 0.3 0.3
Illnesses of father: None of the above (group 1) 1.5 1.8 3.0 0.8 -1.7
Smoking status: Current 0.2 0.3 0.7 0.1 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.4 0.6 0.5
Whole body water mass 0.2 1.3 2.1 -0.7 -1.4
Leg predicted mass (right) 0.3 1.6 3.1 -0.5 -1.8
Arm fat mass (left) 1.3 5.2 5.8 -2.1 -2.4
Number of self-reported non-cancer illnesses 3.5 6.1 10.0 -3.2 1.5
Average weekly champagne plus white wine intake 0.1 0.2 0.2 0.5 0.3
Miserableness 2.1 3.7 7.3 -2.7 0.1
Guilty feelings 0.5 0.8 1.4 0.5 1.2
Wears glasses or contact lenses 1.2 1.4 2.5 -1.6 0.6
Ever taken oral contraceptive pill 0.2 0.2 0.2 0.5 0.4
Hearing aid user 0.1 0.1 0.2 0.1 0.4
Mother’s age at death 1.0 1.3 1.9 1.4 -0.8
Financial situation satisfaction 0.2 0.2 0.4 -0.1 -0.6
Tinnitus: Yes, now most or all of the time 1.9 2.2 2.5 1.4 -1.6
Commuting to job workplace: Public transport 0.6 0.7 1.2 0.5 -1.1
Eye problems/disorders: Glaucoma 1.5 1.8 3.5 -0.2 1.9
Medication: Blood pressure 2.3 4.4 8.0 -2.8 -0.9
Pain type(s) experienced in last month: Hip pain 2.5 3.1 4.1 -2.0 1.5
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.7 -0.2 0.9
High cholesterol (Self-reported) 0.4 0.6 1.1 -1.1 0.3
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.4 0.2
Medication: Paracetamol 1.7 2.6 4.3 -2.1 1.0
Medication: Lisinopril 0.0 0.0 0.1 -0.0 -0.3
Medication: Atorvastatin 0.5 0.6 0.9 -0.5 -1.0
Illnesses of father: High blood pressure 1.1 1.3 1.4 1.2 -1.1
Alcohol drinker status: Never 2.2 2.6 4.4 0.9 -2.1
Ever smoked 0.9 1.7 2.6 -1.6 0.9
Basal metabolic rate 0.4 2.1 3.1 -1.0 -1.8
Leg fat percentage (left) 2.1 7.8 10.2 -3.2 -2.3
Arm fat-free mass (left) 0.4 1.9 2.9 -0.9 -1.7
Number of operations (self-reported) 0.4 0.6 1.1 -1.0 -0.3
Average weekly beer plus cider intake 0.3 0.5 0.9 0.0 -1.0
Irritability 0.2 0.3 0.4 -0.4 0.6
Risk taking 0.4 0.5 0.7 0.9 -0.6
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.3 -0.5 1.2
Fractured/broken bones in last 5 years 1.7 2.2 4.2 2.0 -0.4
Age started oral contraceptive pill 0.5 0.7 0.9 -0.9 0.7
Diastolic blood pressure, automated reading 2.4 7.4 8.2 2.9 -2.6
Ever depressed for a whole week 1.2 1.5 2.6 -0.6 -1.6
Unable to work because of sickness or disability 0.7 0.9 1.6 -0.4 1.3
Commuting to job workplace: Cycle 0.1 0.1 0.3 -0.0 0.5
Myopia 2.0 2.9 3.8 1.9 -1.4
Vascular/heart problems diagnosed by doctor 0.6 1.6 3.1 1.8 0.3
Cholesterol lowering medication 2.7 4.0 7.9 -2.8 -0.0
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 2.5 -0.7 -1.6
Pain experienced in last month 0.1 0.1 0.2 -0.3 -0.5
Supplements: Calcium 1.1 1.2 2.4 1.5 0.0
Basal cell carcinoma (self-reported) 0.8 1.0 1.8 -1.4 0.3
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.3 -1.5 0.3
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 1.5 -1.2 0.8
Heart disease (siblings) 1.1 1.4 1.7 -1.3 1.0
Alcohol drinker status: Previous 0.0 0.0 0.1 -0.1 -0.3
Pack years of smoking 0.8 1.1 1.3 -1.1 -1.0
Impedance of whole body 0.6 3.1 4.6 2.2 1.3
Leg fat mass (left) 1.6 6.4 7.4 -2.7 -2.3
Arm predicted mass (left) 0.4 1.9 2.9 -1.0 -1.7