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chr10:100,679,684-103,018,321

Best TWAS P=6.29e-12 · Best GWAS P=4.45e-12 conditioned to 0.00724

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DNMBP	0.08	0.05	enet	7	0.07	4.1e-09	5.3	5.7	1.4e-08	0.83	0.23	0.77	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SEC31B	0.13	0.21	lasso	3	0.20	4.1e-24	-5.5	5.5	4.8e-08	0.05	0.88	0.12	FALSE
3	GTEx	Adipose Subcutaneous	SEC31B	0.32	0.39	lasso	5	0.38	5.1e-33	-5.4	5.5	3.3e-08	0.05	0.84	0.16	FALSE
4	GTEx	Adipose Visceral Omentum	SEC31B	0.18	0.28	lasso	10	0.27	1.5e-14	-5.9	5.6	1.6e-08	0.06	0.49	0.51	FALSE
5	GTEx	Artery Aorta	SEC31B	0.26	0.24	lasso	3	0.23	1.0e-12	-5.4	5.2	2.2e-07	0.02	0.64	0.36	FALSE
6	GTEx	Artery Coronary	SEC31B	0.14	0.05	lasso	4	0.04	1.5e-02	-5.9	6.0	2.1e-09	0.06	0.29	0.41	FALSE
7	GTEx	Artery Tibial	SEC31B	0.25	0.32	lasso	6	0.33	1.3e-26	-5.8	5.8	5.8e-09	0.05	0.40	0.60	FALSE
8	GTEx	Brain Cerebellar Hemisphere	SLC25A28	0.12	0.02	enet	6	0.00	2.4e-01	-5.9	6.2	4.8e-10	0.79	0.07	0.42	TRUE
9	GTEx	Brain Cerebellum	DNMBP	0.33	0.02	enet	9	0.09	1.5e-03	-5.7	5.5	4.5e-08	0.74	0.16	0.41	FALSE
10	GTEx	Brain Cortex	SEC31B	0.18	0.09	lasso	7	0.07	7.1e-03	-5.9	5.8	6.2e-09	0.05	0.28	0.33	FALSE
11	GTEx	Breast Mammary Tissue	SEC31B	0.17	0.26	lasso	5	0.25	2.9e-13	-5.4	5.6	2.4e-08	0.05	0.68	0.32	FALSE
12	GTEx	Breast Mammary Tissue (Male)	SEC31B	0.13	0.08	lasso	4	0.10	3.0e-03	-5.4	5.4	5.4e-08	0.05	0.23	0.19	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	SEC31B	0.23	0.11	enet	13	0.12	9.2e-05	-5.4	5.3	1.1e-07	-0.02	0.54	0.29	FALSE
14	GTEx	Cells Transformed fibroblasts	SEC31B	0.14	0.19	enet	17	0.22	1.6e-16	-5.5	5.8	6.3e-09	0.05	0.50	0.50	FALSE
15	GTEx	Cells Transformed fibroblasts	NDUFB8	0.11	0.03	enet	30	0.02	1.3e-02	-5.9	-6.5	9.0e-11	-0.04	0.54	0.34	TRUE
16	GTEx	Colon Transverse	SEC31B	0.28	0.12	lasso	3	0.09	3.3e-05	-5.4	5.4	6.5e-08	0.06	0.78	0.21	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	SEC31B	0.15	0.21	lasso	4	0.20	8.0e-08	-5.5	5.4	5.4e-08	0.05	0.75	0.22	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	DNMBP	0.14	0.05	lasso	5	0.01	1.0e-01	5.5	5.4	7.1e-08	0.82	0.05	0.68	FALSE
19	GTEx	Esophagus Mucosa	SEC31B	0.14	0.18	lasso	4	0.17	2.0e-11	-5.4	5.4	5.4e-08	0.05	0.81	0.19	FALSE
20	GTEx	Esophagus Mucosa	HIF1AN	0.14	0.08	lasso	7	0.09	2.2e-06	-5.1	5.1	2.7e-07	0.06	0.95	0.03	FALSE
21	GTEx	Esophagus Mucosa	PHBP9	0.07	0.05	enet	13	0.05	3.6e-04	3.2	6.2	5.5e-10	0.44	0.15	0.32	FALSE
22	GTEx	Esophagus Muscularis	SEC31B	0.18	0.19	lasso	4	0.20	4.5e-12	-5.5	5.5	4.0e-08	0.05	0.80	0.20	FALSE
23	GTEx	Heart Atrial Appendage	SEC31B	0.19	0.11	enet	25	0.09	5.2e-05	-6.0	5.6	1.8e-08	0.02	0.54	0.44	FALSE
24	GTEx	Heart Left Ventricle	SEC31B	0.09	0.07	lasso	1	0.04	2.1e-03	-6.0	6.0	1.5e-09	0.05	0.32	0.34	FALSE
25	GTEx	Lung	SEC31B	0.19	0.21	enet	18	0.20	2.0e-15	-5.9	5.8	5.1e-09	0.05	0.40	0.60	FALSE
26	GTEx	Muscle Skeletal	SEC31B	0.08	0.09	lasso	5	0.08	4.9e-08	-5.9	6.0	1.9e-09	0.07	0.41	0.59	FALSE
27	GTEx	Muscle Skeletal	HIF1AN	0.05	0.06	lasso	1	0.05	1.6e-05	-5.5	-5.5	3.6e-08	-0.05	0.91	0.04	FALSE
28	GTEx	Nerve Tibial	SEC31B	0.42	0.42	lasso	9	0.43	1.4e-32	-5.4	5.7	1.2e-08	0.05	0.67	0.33	FALSE
29	GTEx	Ovary	SEC31B	0.19	0.18	lasso	3	0.11	9.9e-04	-5.8	5.7	1.0e-08	0.09	0.15	0.14	FALSE
30	GTEx	Pancreas	SEC31B	0.24	0.19	lasso	5	0.17	9.9e-08	-5.4	5.5	2.9e-08	0.04	0.68	0.30	FALSE
31	GTEx	Prostate	SEC31B	0.18	0.14	lasso	2	0.12	6.7e-04	-5.5	5.5	3.9e-08	0.05	0.34	0.17	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	SEC31B	0.15	0.16	lasso	4	0.15	8.3e-09	-5.4	5.4	5.4e-08	0.05	0.67	0.32	FALSE
33	GTEx	Skin Sun Exposed Lower leg	SEC31B	0.20	0.34	lasso	4	0.34	8.3e-29	-5.4	5.7	1.4e-08	0.05	0.65	0.35	FALSE
34	GTEx	Skin Sun Exposed Lower leg	HIF1AN	0.07	0.05	lasso	8	0.03	2.2e-03	-5.1	5.5	3.1e-08	0.05	0.77	0.18	FALSE
35	GTEx	Spleen	SEC31B	0.21	0.12	lasso	3	0.05	2.3e-02	-5.4	5.4	8.3e-08	0.04	0.25	0.19	FALSE
36	GTEx	Stomach	SEC31B	0.19	0.12	lasso	19	0.11	9.3e-06	-5.9	5.9	4.4e-09	0.04	0.43	0.56	FALSE
37	GTEx	Testis	SEC31B	0.11	0.11	lasso	5	0.08	2.5e-04	-5.5	5.4	5.3e-08	0.05	0.75	0.12	FALSE
38	GTEx	Thyroid	SEC31B	0.28	0.32	lasso	5	0.31	4.9e-24	-5.4	5.2	1.9e-07	0.06	0.83	0.17	FALSE
39	GTEx	Uterus	SEC31B	0.40	0.14	lasso	18	0.05	3.1e-02	-5.2	5.6	1.7e-08	0.09	0.28	0.26	FALSE
40	GTEx	Vagina	SEC31B	0.32	0.04	enet	33	0.12	8.7e-04	-5.8	6.9	6.3e-12	0.04	0.05	0.68	TRUE
41	GTEx	Whole Blood	SEC31B	0.11	0.14	lasso	7	0.12	1.8e-11	-5.9	5.8	6.9e-09	0.05	0.40	0.60	FALSE
42	GTEx	Whole Blood	HIF1AN	0.15	0.12	enet	7	0.12	8.7e-11	-5.1	5.3	1.5e-07	0.05	0.96	0.04	FALSE
43	METSIM	Adipose	SEC31B	0.15	0.27	enet	29	0.28	1.0e-41	-5.5	5.7	1.2e-08	0.05	0.77	0.23	FALSE
44	NTR	Blood	HIF1AN	0.02	0.03	lasso	2	0.02	1.4e-07	-5.5	5.6	2.2e-08	0.05	0.97	0.03	FALSE
45	NTR	Blood	SEC31B	0.03	0.03	lasso	4	0.03	1.1e-10	-5.5	5.7	1.6e-08	0.06	0.85	0.15	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	SEC31B	0.13	0.17	enet	36	0.18	3.0e-22	-5.5	5.6	1.8e-08	0.03	0.74	0.26	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC31B	0.09	0.13	blup	51	0.15	7.1e-29	-5.5	5.7	1.4e-08	0.06	0.09	0.91	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	SEC31B	0.06	0.07	blup	51	0.08	2.9e-05	-6.0	5.7	1.3e-08	0.05	0.04	0.96	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ABCC2	0.04	0.04	enet	11	0.04	3.1e-05	5.8	-5.3	1.2e-07	-0.75	0.03	0.92	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SEC31B	0.05	0.05	blup	51	0.05	1.3e-06	-5.4	5.4	8.4e-08	0.04	0.16	0.84	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEC31B	0.05	0.05	blup	51	0.05	8.9e-07	-5.5	5.6	2.0e-08	0.05	0.08	0.92	FALSE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SEC31B	0.14	0.10	lasso	7	0.10	1.6e-06	-5.2	5.3	1.1e-07	0.05	0.15	0.84	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	NDUFB8	0.02	0.01	blup	38	0.01	1.6e-02	-6.0	-5.5	4.5e-08	-0.06	0.02	0.78	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	WNT8B	0.07	0.10	blup	34	0.11	1.7e-12	-5.8	-6.0	2.6e-09	-0.05	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	SEC31B	0.06	0.08	enet	10	0.09	4.6e-11	-5.4	5.7	1.4e-08	0.06	0.08	0.92	FALSE
56	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SEC31B	0.11	0.12	enet	15	0.13	1.5e-14	-5.1	5.3	1.3e-07	0.04	0.10	0.90	FALSE
57	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SEC31B	0.10	0.09	blup	51	0.10	2.5e-07	-5.8	5.8	5.6e-09	0.04	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SEC31B	0.15	0.14	lasso	12	0.15	8.5e-07	-5.5	5.6	1.9e-08	0.05	0.07	0.93	FALSE
59	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HIF1AN	0.19	-0.01	blup	40	0.06	2.9e-03	-5.9	-5.6	2.0e-08	-0.02	0.02	0.78	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC31B	0.23	0.23	enet	20	0.26	8.6e-27	-5.5	5.7	1.3e-08	0.04	0.04	0.96	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	WNT8B	0.05	0.04	lasso	2	0.01	9.7e-03	-5.8	5.7	1.1e-08	0.07	0.02	0.86	FALSE
62	The Cancer Genome Atlas	Stomach Adenocarcinoma	SEC31B	0.07	0.09	blup	51	0.09	4.1e-07	-5.9	5.9	4.0e-09	0.05	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SEC31B	0.24	0.20	blup	51	0.28	1.7e-10	-5.2	5.7	1.5e-08	0.06	0.04	0.96	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	SEC31B	0.12	0.19	blup	51	0.20	1.1e-18	-5.9	5.7	1.1e-08	0.06	0.02	0.98	FALSE