Hub : Genes

ABCC2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.244 0.0780 0.00062 0.165 NA 0.137 NA 0.158 8.4e-08 NA 1.2e-06 NA 1.6e-07
2 TCGA Colon Adenocarcinoma 0.197 0.0840 0.00095 0.080 0.027 0.082 NA 0.090 2.2e-05 0.01100 1.7e-05 NA 7.1e-06
3 TCGA Head and Neck Squamous Cell Carcinoma 0.044 0.0271 0.00051 0.040 0.026 0.039 NA 0.039 2.7e-05 0.00062 3.1e-05 NA 3.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 0.9 2.2 -0.5 -1.5 -0.4
Bipolar Disorder or Schizophrenia 0.4 1.1 2.3 -0.9 -1.5 -0.2
Depressed Affect (Nagel 2018) 0.5 1.0 2.5 0.3 0.6 -1.6
Depression (Nagel 2018) 1.6 2.4 4.2 0.9 1.5 -2.0
Intelligence (Savage-Jansen 2018) 2.1 6.5 12.2 0.4 3.5 -2.7
Neuroticism (Nagel 2018) 1.6 3.9 10.3 -1.1 0.2 -3.2
Schizophrenia (2018) 0.2 0.4 0.6 -0.8 -0.8 0.1
Schizophrenia vs Biploar Disorder 0.2 0.3 0.8 -0.1 0.1 0.9
Worry (Nagel 2018) 0.9 1.8 2.3 -1.5 -1.1 -1.4
Alzheimer’s Disease (in mother) 1.4 1.6 2.3 -0.6 -1.5 -1.5
Alzheimer’s Disease (in father) 0.0 0.0 0.1 -0.1 0.2 0.3
Alzheimer’s Disease (including proxy) 0.7 1.0 1.9 -0.6 -1.4 -0.9
Crohns Disease (2017) 0.6 1.2 3.0 1.7 0.7 -0.5
Irritable Bowel Disease (IBD) 2.1 4.9 12.3 3.5 1.6 0.0
Ulcerative Colitis (UC) 3.6 6.7 16.7 4.1 1.6 1.0
Major Depression (MDD) 2.1 2.6 6.9 0.2 0.9 -2.6
Reaction Time 0.6 1.1 2.1 -1.5 -0.7 -0.7
Verbal and Numeric Reasoning (VNR) 1.4 3.4 6.6 0.2 2.6 -1.8
Breast Cancer 0.4 1.0 2.6 -0.6 0.3 -1.6
Ovarian Cancer 0.2 0.2 0.5 0.1 0.3 0.7
Prostate Cancer 0.2 0.3 0.9 -0.0 -0.9 0.2
Age at First Birth 2.7 3.9 5.9 0.2 2.4 -2.4
Bipolar Disorder (2011) 0.4 0.4 0.9 0.6 0.0 0.9
Body Mass Index (BMI) (2010) 0.7 1.0 2.7 -1.7 -0.5 -0.2
Coronary Artery Disease (CAD) 0.0 0.1 0.1 0.1 0.3 0.3
Crohns Disease (2012) 0.6 0.9 2.2 0.6 1.5 -0.5
Mean Putamen Volume 0.2 0.3 0.5 -0.7 0.3 -0.4
Fasting Glucose 0.7 0.8 2.1 0.5 -1.4 0.2
HbA1C 1.4 1.6 4.4 -2.1 0.5 -0.3
HDL Cholesterol 0.9 1.4 2.7 1.2 1.7 0.0
LDL Cholesterol 1.6 2.6 4.1 0.1 2.0 -1.9
Lupus 0.2 0.3 0.4 0.4 -0.6 0.4
Neuroticism (2016) 0.8 1.1 2.1 0.6 0.9 -1.5
Primary Biliary Cirrhosis 1.4 2.0 3.3 1.7 1.8 0.1
Rheumatoid Arthritis 0.2 0.3 0.7 0.4 0.2 0.8
Schizophrenia (2014) 1.0 2.2 4.4 -1.4 -2.1 -0.3
Triglycerides 0.2 0.3 0.5 0.5 -0.7 0.1
Type 2 Diabetes (T2D) (2012) 0.9 1.0 1.9 -0.8 -1.4 -0.7
Ulcerative Colitis 3.6 5.2 10.9 3.3 1.9 1.0
Blood Eosinophil Count 0.0 0.4 0.5 0.5 0.7 -0.6
Blood Platelet Count 0.8 9.6 18.3 0.4 4.3 -3.2
Blood Red Count 0.4 4.1 9.5 -0.0 1.6 -3.1
Blood White Count 0.1 1.1 2.8 1.7 0.5 0.3
Heel T-Score 0.2 1.7 4.0 -0.0 1.0 2.0
BMI 0.1 0.3 0.8 0.5 0.9 -0.2
Height 0.8 16.3 33.6 -1.2 -5.8 3.7
Waist Hip Ratio (WHR) 0.2 1.1 2.4 -0.4 -0.8 -1.5
Systolic Blood Pressure 0.8 4.0 6.1 0.6 2.4 -2.5
Smoking Status 0.3 0.6 0.8 -0.9 -0.8 0.6
Allergy or Eczema 0.0 0.1 0.2 -0.1 0.0 0.4
Cardiovascular Disease 0.0 0.0 0.1 -0.2 -0.2 -0.2
Hypothyroidism (self reported) 0.4 0.8 1.8 1.4 -0.6 0.5
Respiratory disease 0.1 0.2 0.3 -0.6 -0.4 -0.5
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.3 0.8 0.0 -1.1
Lung FEV1/FVC ratio 0.2 1.0 2.7 -1.6 -0.2 -0.6
Lung FVC 0.2 1.1 2.9 -0.5 -0.2 -1.7
Neuroticism 1.5 3.6 9.1 -0.9 1.0 -3.0
Chronotype (morning person) 1.0 2.3 5.6 0.8 2.4 -0.9
Hair Pigment 0.0 1.0 1.6 1.1 0.6 1.2
Tanning 0.0 0.3 0.7 0.4 0.3 0.9
Hand grip strength (left) 0.5 1.4 3.3 1.0 1.8 0.1
Number of treatments/medications taken 0.1 0.1 0.2 -0.0 0.4 -0.3
Average weekly spirits intake 1.1 1.4 2.1 -1.4 -0.5 -1.4
Sensitivity / hurt feelings 1.3 2.2 3.5 -1.7 0.1 -1.9
Frequency of depressed mood in last 2 weeks 1.5 2.1 5.6 -0.2 0.9 -2.4
Hearing difficulty/problems: Yes 0.4 0.6 1.1 0.1 0.9 -1.1
Relative age of first facial hair 0.5 1.1 1.5 -1.1 -1.2 -0.8
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.8 0.1 -0.6 1.7
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.0 -1.0 0.2 -0.1
Ever had hysterectomy (womb removed) 0.6 0.7 1.4 0.2 0.8 1.2
Systolic blood pressure, automated reading 0.1 0.3 0.5 -0.2 0.7 -0.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.6 0.8 0.5 -0.3
Angina 0.9 1.2 3.1 -0.7 0.3 -1.8
Medication for hormone replacement therapy 0.3 0.3 0.6 -0.5 0.8 0.2
Vitamin and mineral supplements 0.4 0.5 0.9 0.9 0.8 0.1
Supplements: Zinc 1.4 1.6 3.4 -0.5 -1.8 1.0
Medication: Co-codamol 0.3 0.4 0.6 0.6 -0.7 -0.4
Medication: Metformin 0.4 0.6 1.3 1.1 0.7 -0.0
Diabetes (father) 1.1 1.3 4.0 0.0 -2.0 -0.1
Diabetes (mother) 0.7 0.9 2.5 1.6 0.4 -0.2
Severe depression (siblings) 3.3 3.7 5.8 1.9 2.4 1.2
Pack years adult smoking proportion 0.6 0.9 1.8 1.3 0.0 0.9
Impedance of leg (right) 0.2 0.8 1.9 -1.4 -0.5 -0.7
Leg fat-free mass (left) 0.1 0.5 1.3 0.2 -1.1 0.5
Trunk fat percentage 0.1 0.3 0.8 -0.2 0.3 0.9
Hand grip strength (right) 0.7 2.0 3.7 1.4 1.9 0.5
Townsend deprivation index at recruitment 0.3 0.5 1.0 -1.0 -0.5 -0.3
Current tobacco smoking 0.4 0.6 1.3 -0.7 -1.1 -0.4
Average weekly fortified wine intake 0.6 0.6 1.2 0.6 0.7 -1.1
Maternal smoking around birth 0.4 0.6 0.8 -0.6 -0.8 0.9
Fed-up feelings 1.4 2.5 4.4 1.0 1.5 -2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 6.2 0.6 0.8 -2.5
Relative age voice broke 1.1 1.6 3.6 -1.9 -1.1 -0.5
Taking other prescription medications 0.5 0.7 1.7 -0.1 0.6 -1.3
Age when periods started (menarche) 1.7 4.0 7.2 -2.7 -2.0 0.7
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 0.3 0.6 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.3 0.9 -0.0 1.2
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 3.1 0.9 -0.2 1.8
Qualifications: CSEs or equivalent 0.7 0.9 1.8 0.2 -1.0 1.3
Serious illness, injury or assault to yourself 1.6 2.0 2.9 -0.9 -1.7 -1.5
High blood pressure 0.3 0.8 1.2 0.8 1.1 0.8
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.8 -0.5 0.6 -0.9
Multivitamins +/- minerals 0.3 0.4 1.0 -0.4 -1.0 -0.2
Stomach or abdominal pain in last month 2.5 3.1 5.0 2.1 2.2 0.2
Supplements: Glucosamine 0.0 0.0 0.0 -0.0 0.0 -0.1
Diverticular disease/diverticulitis (self-reported) 6.8 8.1 11.0 2.8 3.3 -2.3
Medication: Atenolol 0.1 0.2 0.3 0.6 0.2 0.4
Medication: Levothyroxine sodium 0.6 1.0 2.7 1.6 0.3 0.6
Sitting height 0.5 3.4 6.2 -1.7 -2.5 1.1
Chronic bronchitis/emphysema (father) 0.2 0.3 0.4 0.6 -0.6 0.2
High blood pressure (mother) 0.2 0.3 0.6 -0.4 -0.7 -0.3
Body mass index (BMI) 0.1 0.4 0.8 0.6 0.9 0.3
Impedance of leg (left) 0.2 0.7 2.0 -1.4 -0.4 -0.4
Leg predicted mass (left) 0.1 0.5 1.3 0.3 -1.1 0.5
Trunk fat mass 0.1 0.4 0.8 -0.4 -0.4 0.9
Waist circumference 0.0 0.2 0.3 -0.2 -0.4 -0.6
Number of incorrect matches in round 1.5 2.4 3.1 -1.8 -1.6 1.3
Past tobacco smoking 0.3 0.6 0.9 0.9 -0.2 -0.9
Alcohol usually taken with meals 0.1 0.1 0.3 0.2 0.5 -0.3
Nervous feelings 2.6 4.9 9.0 -2.1 -1.1 -3.0
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.1 0.2 0.5 -1.0
Hearing difficulty/problems with background noise 0.8 1.3 2.1 -0.1 1.4 -1.4
Hair/balding pattern: Pattern 2 0.9 1.2 1.9 1.3 1.4 0.1
Had menopause 0.9 1.2 3.2 -1.8 -0.5 -0.2
Had other major operations 1.0 1.3 3.0 -1.7 0.2 -0.9
Forced vital capacity (FVC) 0.4 1.5 2.1 -1.1 -1.4 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.0 1.0 -0.7 1.4
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.5 -0.7 0.2 -0.1
Qualifications: None of the above 0.7 1.5 3.6 0.1 -1.9 0.9
Financial difficulties in last 2 years 0.7 0.9 2.3 1.5 -0.6 -0.0
Mouth/teeth dental problems 0.5 0.7 1.0 -1.0 0.6 -0.9
Heart attack 0.4 0.5 0.7 -0.4 0.8 -0.8
Allergy 0.5 1.2 1.8 1.3 -0.2 1.3
Pain all over the body in last month 0.4 0.4 1.1 1.0 -0.3 0.2
Diabetes (self-reported) 0.2 0.3 0.6 0.8 -0.0 -0.6
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 4.0 0.0 1.3 -2.0
Medication: Ramipril 0.3 0.3 0.5 0.1 0.7 -0.7
Medication: Simvastatin 1.0 1.4 2.9 1.1 -0.5 1.7
Fluid intelligence score 1.4 2.9 5.7 0.5 2.4 -1.7
Illnesses of siblings 1.0 1.4 2.2 -1.1 -1.5 0.9
Neuroticism score 2.2 4.5 9.7 -2.0 -0.0 -3.1
Weight 0.1 0.4 0.6 -0.2 -0.8 0.6
Impedance of arm (right) 0.2 1.0 1.5 -1.1 -1.2 0.3
Arm fat percentage (right) 0.1 0.5 0.8 0.4 0.9 0.7
Trunk fat-free mass 0.1 0.9 2.0 0.4 -1.4 0.6
Hip circumference 0.1 0.3 0.4 0.2 -0.5 0.7
Time employed in main current job 0.7 0.8 1.6 0.9 1.2 -0.2
Alcohol intake versus 10 years previously 1.0 1.4 2.5 0.6 1.2 -1.6
Father’s age at death 1.0 1.4 3.6 1.9 -0.1 0.7
Worrier / anxious feelings 1.9 3.5 6.7 -1.9 0.6 -2.6
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 2.0 1.4 0.9 -1.2
Falls in the last year 0.1 0.1 0.3 0.5 -0.2 0.3
Hair/balding pattern: Pattern 3 0.1 0.2 0.3 -0.4 -0.4 -0.5
Number of live births 1.9 2.7 7.5 0.6 -0.5 2.7
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 2.6 -1.0 -1.0 -1.6
Pulse rate 0.5 0.9 1.8 0.3 0.9 -1.3
Happiness 0.4 0.4 0.7 0.2 -0.9 0.7
Noisy workplace 1.1 1.3 1.9 -1.1 -0.8 -1.4
Qualifications: A levels/AS levels or equivalent 0.7 1.6 2.9 1.0 1.7 -1.0
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 2.9 1.7 -0.9 0.7
Mouth/teeth dental problems: Dentures 0.5 0.9 2.4 1.6 0.5 0.2
Asthma 0.6 1.2 2.5 -0.2 1.0 -1.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.7 -0.8 0.3 -0.7
Medication: Cholesterol lowering 1.2 1.9 3.4 1.9 0.4 1.4
Depression (self-reported) 1.3 1.6 3.5 1.9 1.0 0.5
Medication: Lansoprazole 0.3 0.3 0.7 -0.5 -0.1 0.8
Prospective memory result 0.7 0.8 1.8 -0.2 -1.3 0.8
Lung cancer (father) 1.1 1.2 1.8 -0.9 -1.0 1.4
Illnesses of mother 0.8 1.0 2.5 0.4 1.6 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.3 -0.5 -1.1 -1.2
Pulse wave Arterial Stiffness index 0.6 0.7 1.4 0.8 1.2 -0.1
Impedance of arm (left) 0.1 0.7 1.2 -1.1 -0.8 0.4
Arm fat mass (right) 0.0 0.1 0.1 0.1 0.3 0.4
Trunk predicted mass 0.2 0.9 2.1 0.4 -1.5 0.6
Standing height 0.6 6.2 13.5 -2.1 -3.7 0.8
Length of working week for main job 1.6 1.8 2.8 1.7 1.0 1.2
Exposure to tobacco smoke at home 0.0 0.1 0.1 0.3 -0.3 -0.1
Breastfed as a baby 2.5 3.1 8.9 -3.0 -0.0 -0.7
Tense / ‘highly strung’ 0.3 0.5 1.3 -0.3 -1.1 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 4.2 0.6 0.2 -2.1
Hair/balding pattern: Pattern 4 0.2 0.4 1.1 0.1 1.0 0.2
Birth weight of first child 0.1 0.2 0.4 0.1 -0.7 0.3
Peak expiratory flow (PEF) 0.1 0.2 0.4 -0.5 -0.2 -0.6
Pulse wave reflection index 0.0 0.0 0.1 0.1 -0.3 -0.2
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.3 0.5 -0.5 -0.2
Loud music exposure frequency 0.2 0.2 0.4 -0.1 -0.3 -0.7
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 0.1 0.5 -0.6
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 1.8 1.4 0.6 1.0
Blood clot in the leg (DVT) 2.3 3.0 6.6 -0.8 -2.6 1.3
Medication: Paracetamol 0.3 0.6 1.1 0.5 -0.5 -1.1
Headache pain in last month 0.1 0.3 0.7 0.2 0.2 -0.8
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.8 -0.8 -0.6 -1.3
Glaucoma (self-reported) 0.7 0.8 1.1 0.8 0.9 -1.1
Gout (self-reported) 0.5 0.7 1.8 0.4 1.4 0.4
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.0 1.0 0.9 0.5
Medication: Amlodipine 0.2 0.2 0.4 -0.3 -0.6 -0.5
Medication: Ventolin 100micrograms inhaler 0.8 1.1 2.5 1.6 0.2 0.8
Birth weight 0.7 1.5 4.5 0.1 2.1 -0.1
Chronic bronchitis/emphysema (mother) 1.1 1.3 2.5 0.7 -0.9 1.6
High blood pressure (siblings) 0.8 1.1 2.2 0.3 1.5 -1.0
Forced vital capacity (FVC), Best measure 0.2 0.7 1.8 -0.3 -1.4 -0.5
Body fat percentage 0.1 0.3 0.6 -0.2 0.5 0.8
Leg fat percentage (right) 0.1 0.3 0.6 -0.3 0.8 0.3
Arm fat-free mass (right) 0.1 0.5 0.9 0.6 -0.9 0.6
Exposure to tobacco smoke outside home 0.7 0.9 1.6 -1.3 -0.9 -0.3
Comparative body size at age 10 0.1 0.3 0.8 0.1 -0.0 0.9
Number of full brothers 0.3 0.4 0.5 -0.5 0.7 0.6
Worry too long after embarrassment 3.3 5.6 10.3 -2.5 0.0 -3.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 0.9 -0.9 0.6 -1.0
Wheeze or whistling in the chest in last year 0.0 0.1 0.1 0.2 -0.2 0.3
Number of children fathered 1.8 2.0 4.8 0.8 -0.8 2.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.6 0.1 -0.0 0.7
Age at first live birth 1.1 2.0 4.0 1.1 2.0 -0.8
Pulse wave peak to peak time 1.0 1.2 2.2 -1.2 -1.5 0.0
Health satisfaction 1.6 2.1 4.3 2.1 1.3 -0.4
Shortness of breath walking on level ground 1.0 1.2 2.5 1.0 1.6 -0.2
Qualifications: College or University degree 0.6 1.8 3.6 1.2 1.9 0.6
Eye problems/disorders: None of the above 1.2 1.4 2.5 -0.1 -1.6 1.3
Mouth/teeth dental problems: Loose teeth 2.6 3.0 5.2 -1.9 -2.3 -0.6
Emphysema/chronic bronchitis 0.1 0.2 0.4 -0.6 0.2 -0.3
Medication for pain relief, constipation, heartburn 0.3 0.5 0.9 1.0 -0.4 0.7
Neck or shoulder pain in last month 0.3 0.4 0.7 0.8 0.6 0.3
Medication: Blood pressure 0.5 0.8 1.2 1.1 0.7 0.9
Angina (self-reported) 0.9 1.1 3.0 -0.6 0.3 -1.7
Migraine (self-reported) 0.4 0.5 1.2 1.1 0.5 -0.2
Medication: Ibuprofen 0.5 0.6 1.2 -1.1 0.4 -0.6
Medication: Allopurinol 0.5 0.7 1.3 -1.2 0.8 0.1
Medication: Omeprazole 4.4 5.2 7.7 -2.8 0.6 -2.7
Medication: Seretide 50 evohaler 0.8 0.9 1.4 0.6 -0.9 1.2
Mean time to correctly identify matches 0.3 0.6 1.4 -1.2 -0.1 -0.7
Heart disease (mother) 0.2 0.3 0.4 -0.7 -0.5 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 4.4 2.1 -0.2 -0.2
Whole body fat mass 0.1 0.3 0.6 -0.3 -0.2 0.8
Leg fat mass (right) 0.0 0.1 0.3 -0.5 -0.1 0.2
Arm predicted mass (right) 0.1 0.4 0.7 0.6 -0.9 0.5
Pulse rate, automated reading 4.6 14.7 28.0 -0.0 4.0 -5.3
Alcohol intake frequency. 0.7 1.7 2.4 1.2 1.5 -1.1
Comparative height size at age 10 0.5 2.7 6.0 -0.4 -2.4 1.4
Number of full sisters 1.0 1.2 3.3 -0.6 0.1 -1.8
Suffer from ‘nerves’ 1.4 2.3 3.5 -1.8 -0.4 -1.9
Overall health rating 0.4 0.9 2.7 -0.2 -0.3 -1.6
Chest pain or discomfort 0.7 1.1 2.4 -0.8 0.3 -1.6
Had major operations 0.1 0.1 0.2 -0.4 -0.1 -0.4
Age at last live birth 0.4 0.6 1.3 0.6 1.2 -0.4
Family relationship satisfaction 0.4 0.5 1.2 1.1 0.5 -0.1
Leg pain on walking 1.4 1.7 3.2 -1.4 -0.4 -1.8
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.5 -0.5 0.4 -1.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.1 -0.2 -1.4 -0.2
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.1 -0.3 1.1 0.8
Medication: Aspirin 0.6 0.8 1.5 -1.2 0.2 0.9
Supplements: Vitamin C 0.9 1.1 2.1 -1.4 0.1 -1.0
Knee pain experienced in last month 0.1 0.2 0.4 0.1 -0.2 -0.7
Hypertension (Self-reported) 0.3 0.8 0.9 1.0 0.7 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.7 3.8 -1.9 0.5 -1.1
Illnesses of father: Heart disease 1.6 2.3 4.3 0.3 2.1 -1.6
Illnesses of siblings: Diabetes 1.2 1.4 2.2 0.0 1.5 -1.4
Smoking status: Previous 0.4 0.5 1.4 -0.5 -0.0 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.3 0.2 -0.5 -0.3
Whole body fat-free mass 0.1 0.6 1.4 0.4 -1.2 0.5
Leg fat-free mass (right) 0.1 0.7 1.5 0.3 -1.2 0.7
Arm fat percentage (left) 0.1 0.6 1.0 0.5 1.0 0.7
Average weekly red wine intake 0.4 0.7 1.2 -0.7 1.1 -0.6
Handedness (chirality/laterality): Left-handed 0.9 1.1 1.8 -1.3 -0.3 -1.2
Mood swings 0.2 0.4 0.7 0.7 0.8 -0.1
Loneliness, isolation 1.5 2.1 2.6 -1.3 -1.6 -1.4
Long-standing illness, disability or infirmity 0.4 0.6 1.4 0.6 1.2 -0.3
Ever had bowel cancer screening 1.1 1.2 1.9 0.9 1.0 1.4
Diabetes diagnosed by doctor 0.1 0.1 0.2 0.4 -0.1 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 -0.2 0.8 0.5
Friendships satisfaction 0.4 0.6 1.4 -0.1 1.2 -0.5
Qualifications: nursing, teaching 0.1 0.2 0.3 0.0 0.6 0.4
Commuting to job workplace: Walk 0.6 0.6 1.1 -0.6 -0.6 1.1
Eye problems/disorders: Cataract 1.0 1.1 1.2 -1.1 1.1 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.2 -1.5 -0.9 -0.0
Medication for cholesterol 0.1 0.2 0.5 0.7 0.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.1 1.4 0.3 1.5
Back pain experienced in last month 0.2 0.3 0.4 -0.4 -0.5 -0.6
Mineral and other dietary supplements 0.1 0.2 0.5 0.2 -0.1 -0.7
Breast cancer (self-reported) 0.6 0.7 1.2 -0.5 -1.1 -0.8
Asthma (self-reported) 0.5 1.0 1.8 0.0 1.1 -1.3
Osteoporosis (self-reported) 1.3 1.7 2.2 -1.2 -1.5 1.2
Osteoarthritis (self-reported) 0.6 0.8 1.2 1.1 1.1 -0.0
Medication: Aspirin 0.6 0.8 1.4 -1.2 0.1 1.1
Medication: Gliclazide 0.6 0.6 1.0 0.4 0.8 -1.0
Illnesses of father: None of the above (group 1) 0.1 0.2 0.5 0.1 0.2 0.7
Smoking status: Current 0.6 1.0 1.4 -1.2 -1.0 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.3 -0.3 -1.1 -0.6
Whole body water mass 0.1 0.7 1.5 0.4 -1.2 0.6
Leg predicted mass (right) 0.1 0.7 1.6 0.2 -1.2 0.6
Arm fat mass (left) 0.0 0.2 0.3 0.3 0.5 0.4
Number of self-reported non-cancer illnesses 0.4 0.7 1.2 1.1 0.9 0.1
Average weekly champagne plus white wine intake 0.7 1.0 2.6 -0.5 0.0 -1.6
Miserableness 1.0 1.7 4.0 -0.3 0.9 -2.0
Guilty feelings 2.5 3.8 4.3 -1.9 -1.9 -2.1
Wears glasses or contact lenses 1.4 1.6 3.7 -0.6 1.9 -0.9
Ever taken oral contraceptive pill 0.3 0.4 1.0 -0.3 0.0 -1.0
Hearing aid user 0.6 0.7 1.3 1.1 -0.7 0.5
Mother’s age at death 0.4 0.5 0.8 -0.7 -0.5 0.9
Financial situation satisfaction 0.0 0.1 0.1 -0.2 -0.4 0.1
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.3 -0.5 0.4 -0.5
Commuting to job workplace: Public transport 0.1 0.1 0.2 -0.4 0.3 0.1
Eye problems/disorders: Glaucoma 0.3 0.4 1.2 -0.0 0.1 -1.1
Medication: Blood pressure 0.1 0.2 0.5 -0.3 0.3 -0.7
Pain type(s) experienced in last month: Hip pain 1.5 1.9 3.5 1.3 0.7 -1.9
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.6 -0.5 0.0 1.3
High cholesterol (Self-reported) 2.6 4.6 8.2 2.9 0.3 2.4
Medication: Bendroflumethiazide 0.7 1.1 2.1 1.0 1.4 -0.2
Medication: Paracetamol 0.2 0.3 0.6 0.3 -0.5 -0.8
Medication: Lisinopril 1.2 1.6 4.6 0.3 0.4 2.1
Medication: Atorvastatin 0.1 0.2 0.5 0.7 0.2 -0.1
Illnesses of father: High blood pressure 0.3 0.4 0.9 -0.3 -0.4 0.9
Alcohol drinker status: Never 0.2 0.2 0.4 0.4 0.7 0.3
Ever smoked 0.2 0.4 1.1 -1.0 0.4 0.1
Basal metabolic rate 0.1 0.5 1.2 0.3 -1.1 0.6
Leg fat percentage (left) 0.1 0.2 0.3 -0.4 0.5 0.5
Arm fat-free mass (left) 0.1 0.6 1.5 0.5 -1.2 0.4
Number of operations (self-reported) 0.5 0.8 2.0 -1.4 0.4 -0.3
Average weekly beer plus cider intake 1.1 1.6 3.8 -1.9 -1.0 0.0
Irritability 3.3 5.6 13.5 0.2 1.8 -3.7
Risk taking 1.2 1.8 4.9 -0.6 -2.2 0.2
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.0 0.8 0.4 1.4
Fractured/broken bones in last 5 years 2.4 3.1 4.0 1.5 2.0 -1.7
Age started oral contraceptive pill 0.4 0.6 1.6 -0.2 0.0 -1.3
Diastolic blood pressure, automated reading 1.2 3.8 7.2 -2.0 0.5 -2.7
Ever depressed for a whole week 0.5 0.6 1.7 -1.3 -0.4 0.2
Unable to work because of sickness or disability 1.3 1.6 2.6 1.5 1.6 0.0
Commuting to job workplace: Cycle 0.5 0.6 1.7 1.3 0.2 0.4
Myopia 0.1 0.1 0.2 0.3 0.4 -0.4
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.5 -0.5 -0.7 -0.6
Cholesterol lowering medication 0.2 0.3 0.6 -0.4 -0.3 0.8
Medication: Omeprazole (e.g. Zanprol) 3.0 3.6 5.5 -2.3 1.0 -2.1
Pain experienced in last month 0.2 0.3 0.7 -0.5 -0.3 0.8
Supplements: Calcium 1.8 2.0 3.3 -0.8 -1.4 1.8
Basal cell carcinoma (self-reported) 0.9 1.1 2.8 -0.5 -1.7 0.5
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.4 -0.3 0.6 -0.7
Deep venous thrombosis (DVT) (self-reported) 1.5 2.0 4.4 -0.6 -2.1 1.1
Heart disease (siblings) 0.7 0.8 1.9 1.4 0.7 0.4
Alcohol drinker status: Previous 0.8 0.9 1.6 1.3 0.0 1.1
Pack years of smoking 0.8 1.2 2.2 1.5 0.3 1.1
Impedance of whole body 0.1 0.7 1.4 -1.2 -0.7 0.2
Leg fat mass (left) 0.0 0.2 0.3 -0.5 -0.2 0.5
Arm predicted mass (left) 0.1 0.5 1.2 0.4 -1.1 0.3