Hub : Genes

ABCC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.244	0.0780	0.00062	0.165	NA	0.137	NA	0.158	8.4e-08	NA	1.2e-06	NA	1.6e-07
2	TCGA	Colon Adenocarcinoma	0.197	0.0840	0.00095	0.080	0.027	0.082	NA	0.090	2.2e-05	0.01100	1.7e-05	NA	7.1e-06
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.044	0.0271	0.00051	0.040	0.026	0.039	NA	0.039	2.7e-05	0.00062	3.1e-05	NA	3.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	2.2	-0.5	-1.5	-0.4
Bipolar Disorder or Schizophrenia	0.4	1.1	2.3	-0.9	-1.5	-0.2
Depressed Affect (Nagel 2018)	0.5	1.0	2.5	0.3	0.6	-1.6
Depression (Nagel 2018)	1.6	2.4	4.2	0.9	1.5	-2.0
Intelligence (Savage-Jansen 2018)	2.1	6.5	12.2	0.4	3.5	-2.7
Neuroticism (Nagel 2018)	1.6	3.9	10.3	-1.1	0.2	-3.2
Schizophrenia (2018)	0.2	0.4	0.6	-0.8	-0.8	0.1
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	-0.1	0.1	0.9
Worry (Nagel 2018)	0.9	1.8	2.3	-1.5	-1.1	-1.4
Alzheimer’s Disease (in mother)	1.4	1.6	2.3	-0.6	-1.5	-1.5
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.1	0.2	0.3
Alzheimer’s Disease (including proxy)	0.7	1.0	1.9	-0.6	-1.4	-0.9
Crohns Disease (2017)	0.6	1.2	3.0	1.7	0.7	-0.5
Irritable Bowel Disease (IBD)	2.1	4.9	12.3	3.5	1.6	0.0
Ulcerative Colitis (UC)	3.6	6.7	16.7	4.1	1.6	1.0
Major Depression (MDD)	2.1	2.6	6.9	0.2	0.9	-2.6
Reaction Time	0.6	1.1	2.1	-1.5	-0.7	-0.7
Verbal and Numeric Reasoning (VNR)	1.4	3.4	6.6	0.2	2.6	-1.8
Breast Cancer	0.4	1.0	2.6	-0.6	0.3	-1.6
Ovarian Cancer	0.2	0.2	0.5	0.1	0.3	0.7
Prostate Cancer	0.2	0.3	0.9	-0.0	-0.9	0.2
Age at First Birth	2.7	3.9	5.9	0.2	2.4	-2.4
Bipolar Disorder (2011)	0.4	0.4	0.9	0.6	0.0	0.9
Body Mass Index (BMI) (2010)	0.7	1.0	2.7	-1.7	-0.5	-0.2
Coronary Artery Disease (CAD)	0.0	0.1	0.1	0.1	0.3	0.3
Crohns Disease (2012)	0.6	0.9	2.2	0.6	1.5	-0.5
Mean Putamen Volume	0.2	0.3	0.5	-0.7	0.3	-0.4
Fasting Glucose	0.7	0.8	2.1	0.5	-1.4	0.2
HbA1C	1.4	1.6	4.4	-2.1	0.5	-0.3
HDL Cholesterol	0.9	1.4	2.7	1.2	1.7	0.0
LDL Cholesterol	1.6	2.6	4.1	0.1	2.0	-1.9
Lupus	0.2	0.3	0.4	0.4	-0.6	0.4
Neuroticism (2016)	0.8	1.1	2.1	0.6	0.9	-1.5
Primary Biliary Cirrhosis	1.4	2.0	3.3	1.7	1.8	0.1
Rheumatoid Arthritis	0.2	0.3	0.7	0.4	0.2	0.8
Schizophrenia (2014)	1.0	2.2	4.4	-1.4	-2.1	-0.3
Triglycerides	0.2	0.3	0.5	0.5	-0.7	0.1
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.9	-0.8	-1.4	-0.7
Ulcerative Colitis	3.6	5.2	10.9	3.3	1.9	1.0
Blood Eosinophil Count	0.0	0.4	0.5	0.5	0.7	-0.6
Blood Platelet Count	0.8	9.6	18.3	0.4	4.3	-3.2
Blood Red Count	0.4	4.1	9.5	-0.0	1.6	-3.1
Blood White Count	0.1	1.1	2.8	1.7	0.5	0.3
Heel T-Score	0.2	1.7	4.0	-0.0	1.0	2.0
BMI	0.1	0.3	0.8	0.5	0.9	-0.2
Height	0.8	16.3	33.6	-1.2	-5.8	3.7
Waist Hip Ratio (WHR)	0.2	1.1	2.4	-0.4	-0.8	-1.5
Systolic Blood Pressure	0.8	4.0	6.1	0.6	2.4	-2.5
Smoking Status	0.3	0.6	0.8	-0.9	-0.8	0.6
Allergy or Eczema	0.0	0.1	0.2	-0.1	0.0	0.4
Cardiovascular Disease	0.0	0.0	0.1	-0.2	-0.2	-0.2
Hypothyroidism (self reported)	0.4	0.8	1.8	1.4	-0.6	0.5
Respiratory disease	0.1	0.2	0.3	-0.6	-0.4	-0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	0.8	0.0	-1.1
Lung FEV1/FVC ratio	0.2	1.0	2.7	-1.6	-0.2	-0.6
Lung FVC	0.2	1.1	2.9	-0.5	-0.2	-1.7
Neuroticism	1.5	3.6	9.1	-0.9	1.0	-3.0
Chronotype (morning person)	1.0	2.3	5.6	0.8	2.4	-0.9
Hair Pigment	0.0	1.0	1.6	1.1	0.6	1.2
Tanning	0.0	0.3	0.7	0.4	0.3	0.9
Hand grip strength (left)	0.5	1.4	3.3	1.0	1.8	0.1
Number of treatments/medications taken	0.1	0.1	0.2	-0.0	0.4	-0.3
Average weekly spirits intake	1.1	1.4	2.1	-1.4	-0.5	-1.4
Sensitivity / hurt feelings	1.3	2.2	3.5	-1.7	0.1	-1.9
Frequency of depressed mood in last 2 weeks	1.5	2.1	5.6	-0.2	0.9	-2.4
Hearing difficulty/problems: Yes	0.4	0.6	1.1	0.1	0.9	-1.1
Relative age of first facial hair	0.5	1.1	1.5	-1.1	-1.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.8	0.1	-0.6	1.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	-1.0	0.2	-0.1
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	0.2	0.8	1.2
Systolic blood pressure, automated reading	0.1	0.3	0.5	-0.2	0.7	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.8	0.5	-0.3
Angina	0.9	1.2	3.1	-0.7	0.3	-1.8
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.5	0.8	0.2
Vitamin and mineral supplements	0.4	0.5	0.9	0.9	0.8	0.1
Supplements: Zinc	1.4	1.6	3.4	-0.5	-1.8	1.0
Medication: Co-codamol	0.3	0.4	0.6	0.6	-0.7	-0.4
Medication: Metformin	0.4	0.6	1.3	1.1	0.7	-0.0
Diabetes (father)	1.1	1.3	4.0	0.0	-2.0	-0.1
Diabetes (mother)	0.7	0.9	2.5	1.6	0.4	-0.2
Severe depression (siblings)	3.3	3.7	5.8	1.9	2.4	1.2
Pack years adult smoking proportion	0.6	0.9	1.8	1.3	0.0	0.9
Impedance of leg (right)	0.2	0.8	1.9	-1.4	-0.5	-0.7
Leg fat-free mass (left)	0.1	0.5	1.3	0.2	-1.1	0.5
Trunk fat percentage	0.1	0.3	0.8	-0.2	0.3	0.9
Hand grip strength (right)	0.7	2.0	3.7	1.4	1.9	0.5
Townsend deprivation index at recruitment	0.3	0.5	1.0	-1.0	-0.5	-0.3
Current tobacco smoking	0.4	0.6	1.3	-0.7	-1.1	-0.4
Average weekly fortified wine intake	0.6	0.6	1.2	0.6	0.7	-1.1
Maternal smoking around birth	0.4	0.6	0.8	-0.6	-0.8	0.9
Fed-up feelings	1.4	2.5	4.4	1.0	1.5	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	6.2	0.6	0.8	-2.5
Relative age voice broke	1.1	1.6	3.6	-1.9	-1.1	-0.5
Taking other prescription medications	0.5	0.7	1.7	-0.1	0.6	-1.3
Age when periods started (menarche)	1.7	4.0	7.2	-2.7	-2.0	0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	0.3	0.6	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	0.9	-0.0	1.2
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.1	0.9	-0.2	1.8
Qualifications: CSEs or equivalent	0.7	0.9	1.8	0.2	-1.0	1.3
Serious illness, injury or assault to yourself	1.6	2.0	2.9	-0.9	-1.7	-1.5
High blood pressure	0.3	0.8	1.2	0.8	1.1	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.8	-0.5	0.6	-0.9
Multivitamins +/- minerals	0.3	0.4	1.0	-0.4	-1.0	-0.2
Stomach or abdominal pain in last month	2.5	3.1	5.0	2.1	2.2	0.2
Supplements: Glucosamine	0.0	0.0	0.0	-0.0	0.0	-0.1
Diverticular disease/diverticulitis (self-reported)	6.8	8.1	11.0	2.8	3.3	-2.3
Medication: Atenolol	0.1	0.2	0.3	0.6	0.2	0.4
Medication: Levothyroxine sodium	0.6	1.0	2.7	1.6	0.3	0.6
Sitting height	0.5	3.4	6.2	-1.7	-2.5	1.1
Chronic bronchitis/emphysema (father)	0.2	0.3	0.4	0.6	-0.6	0.2
High blood pressure (mother)	0.2	0.3	0.6	-0.4	-0.7	-0.3
Body mass index (BMI)	0.1	0.4	0.8	0.6	0.9	0.3
Impedance of leg (left)	0.2	0.7	2.0	-1.4	-0.4	-0.4
Leg predicted mass (left)	0.1	0.5	1.3	0.3	-1.1	0.5
Trunk fat mass	0.1	0.4	0.8	-0.4	-0.4	0.9
Waist circumference	0.0	0.2	0.3	-0.2	-0.4	-0.6
Number of incorrect matches in round	1.5	2.4	3.1	-1.8	-1.6	1.3
Past tobacco smoking	0.3	0.6	0.9	0.9	-0.2	-0.9
Alcohol usually taken with meals	0.1	0.1	0.3	0.2	0.5	-0.3
Nervous feelings	2.6	4.9	9.0	-2.1	-1.1	-3.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.1	0.2	0.5	-1.0
Hearing difficulty/problems with background noise	0.8	1.3	2.1	-0.1	1.4	-1.4
Hair/balding pattern: Pattern 2	0.9	1.2	1.9	1.3	1.4	0.1
Had menopause	0.9	1.2	3.2	-1.8	-0.5	-0.2
Had other major operations	1.0	1.3	3.0	-1.7	0.2	-0.9
Forced vital capacity (FVC)	0.4	1.5	2.1	-1.1	-1.4	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.0	1.0	-0.7	1.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	-0.7	0.2	-0.1
Qualifications: None of the above	0.7	1.5	3.6	0.1	-1.9	0.9
Financial difficulties in last 2 years	0.7	0.9	2.3	1.5	-0.6	-0.0
Mouth/teeth dental problems	0.5	0.7	1.0	-1.0	0.6	-0.9
Heart attack	0.4	0.5	0.7	-0.4	0.8	-0.8
Allergy	0.5	1.2	1.8	1.3	-0.2	1.3
Pain all over the body in last month	0.4	0.4	1.1	1.0	-0.3	0.2
Diabetes (self-reported)	0.2	0.3	0.6	0.8	-0.0	-0.6
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	4.0	0.0	1.3	-2.0
Medication: Ramipril	0.3	0.3	0.5	0.1	0.7	-0.7
Medication: Simvastatin	1.0	1.4	2.9	1.1	-0.5	1.7
Fluid intelligence score	1.4	2.9	5.7	0.5	2.4	-1.7
Illnesses of siblings	1.0	1.4	2.2	-1.1	-1.5	0.9
Neuroticism score	2.2	4.5	9.7	-2.0	-0.0	-3.1
Weight	0.1	0.4	0.6	-0.2	-0.8	0.6
Impedance of arm (right)	0.2	1.0	1.5	-1.1	-1.2	0.3
Arm fat percentage (right)	0.1	0.5	0.8	0.4	0.9	0.7
Trunk fat-free mass	0.1	0.9	2.0	0.4	-1.4	0.6
Hip circumference	0.1	0.3	0.4	0.2	-0.5	0.7
Time employed in main current job	0.7	0.8	1.6	0.9	1.2	-0.2
Alcohol intake versus 10 years previously	1.0	1.4	2.5	0.6	1.2	-1.6
Father’s age at death	1.0	1.4	3.6	1.9	-0.1	0.7
Worrier / anxious feelings	1.9	3.5	6.7	-1.9	0.6	-2.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.0	1.4	0.9	-1.2
Falls in the last year	0.1	0.1	0.3	0.5	-0.2	0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	-0.4	-0.4	-0.5
Number of live births	1.9	2.7	7.5	0.6	-0.5	2.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	2.6	-1.0	-1.0	-1.6
Pulse rate	0.5	0.9	1.8	0.3	0.9	-1.3
Happiness	0.4	0.4	0.7	0.2	-0.9	0.7
Noisy workplace	1.1	1.3	1.9	-1.1	-0.8	-1.4
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.9	1.0	1.7	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.9	1.7	-0.9	0.7
Mouth/teeth dental problems: Dentures	0.5	0.9	2.4	1.6	0.5	0.2
Asthma	0.6	1.2	2.5	-0.2	1.0	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.7	-0.8	0.3	-0.7
Medication: Cholesterol lowering	1.2	1.9	3.4	1.9	0.4	1.4
Depression (self-reported)	1.3	1.6	3.5	1.9	1.0	0.5
Medication: Lansoprazole	0.3	0.3	0.7	-0.5	-0.1	0.8
Prospective memory result	0.7	0.8	1.8	-0.2	-1.3	0.8
Lung cancer (father)	1.1	1.2	1.8	-0.9	-1.0	1.4
Illnesses of mother	0.8	1.0	2.5	0.4	1.6	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.3	-0.5	-1.1	-1.2
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	0.8	1.2	-0.1
Impedance of arm (left)	0.1	0.7	1.2	-1.1	-0.8	0.4
Arm fat mass (right)	0.0	0.1	0.1	0.1	0.3	0.4
Trunk predicted mass	0.2	0.9	2.1	0.4	-1.5	0.6
Standing height	0.6	6.2	13.5	-2.1	-3.7	0.8
Length of working week for main job	1.6	1.8	2.8	1.7	1.0	1.2
Exposure to tobacco smoke at home	0.0	0.1	0.1	0.3	-0.3	-0.1
Breastfed as a baby	2.5	3.1	8.9	-3.0	-0.0	-0.7
Tense / ‘highly strung’	0.3	0.5	1.3	-0.3	-1.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.2	0.6	0.2	-2.1
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	0.1	1.0	0.2
Birth weight of first child	0.1	0.2	0.4	0.1	-0.7	0.3
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.5	-0.2	-0.6
Pulse wave reflection index	0.0	0.0	0.1	0.1	-0.3	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	0.5	-0.5	-0.2
Loud music exposure frequency	0.2	0.2	0.4	-0.1	-0.3	-0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.1	0.5	-0.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.8	1.4	0.6	1.0
Blood clot in the leg (DVT)	2.3	3.0	6.6	-0.8	-2.6	1.3
Medication: Paracetamol	0.3	0.6	1.1	0.5	-0.5	-1.1
Headache pain in last month	0.1	0.3	0.7	0.2	0.2	-0.8
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.8	-0.8	-0.6	-1.3
Glaucoma (self-reported)	0.7	0.8	1.1	0.8	0.9	-1.1
Gout (self-reported)	0.5	0.7	1.8	0.4	1.4	0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.0	1.0	0.9	0.5
Medication: Amlodipine	0.2	0.2	0.4	-0.3	-0.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.5	1.6	0.2	0.8
Birth weight	0.7	1.5	4.5	0.1	2.1	-0.1
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.5	0.7	-0.9	1.6
High blood pressure (siblings)	0.8	1.1	2.2	0.3	1.5	-1.0
Forced vital capacity (FVC), Best measure	0.2	0.7	1.8	-0.3	-1.4	-0.5
Body fat percentage	0.1	0.3	0.6	-0.2	0.5	0.8
Leg fat percentage (right)	0.1	0.3	0.6	-0.3	0.8	0.3
Arm fat-free mass (right)	0.1	0.5	0.9	0.6	-0.9	0.6
Exposure to tobacco smoke outside home	0.7	0.9	1.6	-1.3	-0.9	-0.3
Comparative body size at age 10	0.1	0.3	0.8	0.1	-0.0	0.9
Number of full brothers	0.3	0.4	0.5	-0.5	0.7	0.6
Worry too long after embarrassment	3.3	5.6	10.3	-2.5	0.0	-3.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	0.9	-0.9	0.6	-1.0
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.2	-0.2	0.3
Number of children fathered	1.8	2.0	4.8	0.8	-0.8	2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	0.1	-0.0	0.7
Age at first live birth	1.1	2.0	4.0	1.1	2.0	-0.8
Pulse wave peak to peak time	1.0	1.2	2.2	-1.2	-1.5	0.0
Health satisfaction	1.6	2.1	4.3	2.1	1.3	-0.4
Shortness of breath walking on level ground	1.0	1.2	2.5	1.0	1.6	-0.2
Qualifications: College or University degree	0.6	1.8	3.6	1.2	1.9	0.6
Eye problems/disorders: None of the above	1.2	1.4	2.5	-0.1	-1.6	1.3
Mouth/teeth dental problems: Loose teeth	2.6	3.0	5.2	-1.9	-2.3	-0.6
Emphysema/chronic bronchitis	0.1	0.2	0.4	-0.6	0.2	-0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	0.9	1.0	-0.4	0.7
Neck or shoulder pain in last month	0.3	0.4	0.7	0.8	0.6	0.3
Medication: Blood pressure	0.5	0.8	1.2	1.1	0.7	0.9
Angina (self-reported)	0.9	1.1	3.0	-0.6	0.3	-1.7
Migraine (self-reported)	0.4	0.5	1.2	1.1	0.5	-0.2
Medication: Ibuprofen	0.5	0.6	1.2	-1.1	0.4	-0.6
Medication: Allopurinol	0.5	0.7	1.3	-1.2	0.8	0.1
Medication: Omeprazole	4.4	5.2	7.7	-2.8	0.6	-2.7
Medication: Seretide 50 evohaler	0.8	0.9	1.4	0.6	-0.9	1.2
Mean time to correctly identify matches	0.3	0.6	1.4	-1.2	-0.1	-0.7
Heart disease (mother)	0.2	0.3	0.4	-0.7	-0.5	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	4.4	2.1	-0.2	-0.2
Whole body fat mass	0.1	0.3	0.6	-0.3	-0.2	0.8
Leg fat mass (right)	0.0	0.1	0.3	-0.5	-0.1	0.2
Arm predicted mass (right)	0.1	0.4	0.7	0.6	-0.9	0.5
Pulse rate, automated reading	4.6	14.7	28.0	-0.0	4.0	-5.3
Alcohol intake frequency.	0.7	1.7	2.4	1.2	1.5	-1.1
Comparative height size at age 10	0.5	2.7	6.0	-0.4	-2.4	1.4
Number of full sisters	1.0	1.2	3.3	-0.6	0.1	-1.8
Suffer from ‘nerves’	1.4	2.3	3.5	-1.8	-0.4	-1.9
Overall health rating	0.4	0.9	2.7	-0.2	-0.3	-1.6
Chest pain or discomfort	0.7	1.1	2.4	-0.8	0.3	-1.6
Had major operations	0.1	0.1	0.2	-0.4	-0.1	-0.4
Age at last live birth	0.4	0.6	1.3	0.6	1.2	-0.4
Family relationship satisfaction	0.4	0.5	1.2	1.1	0.5	-0.1
Leg pain on walking	1.4	1.7	3.2	-1.4	-0.4	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	-0.5	0.4	-1.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.1	-0.2	-1.4	-0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-0.3	1.1	0.8
Medication: Aspirin	0.6	0.8	1.5	-1.2	0.2	0.9
Supplements: Vitamin C	0.9	1.1	2.1	-1.4	0.1	-1.0
Knee pain experienced in last month	0.1	0.2	0.4	0.1	-0.2	-0.7
Hypertension (Self-reported)	0.3	0.8	0.9	1.0	0.7	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	3.8	-1.9	0.5	-1.1
Illnesses of father: Heart disease	1.6	2.3	4.3	0.3	2.1	-1.6
Illnesses of siblings: Diabetes	1.2	1.4	2.2	0.0	1.5	-1.4
Smoking status: Previous	0.4	0.5	1.4	-0.5	-0.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.3	0.2	-0.5	-0.3
Whole body fat-free mass	0.1	0.6	1.4	0.4	-1.2	0.5
Leg fat-free mass (right)	0.1	0.7	1.5	0.3	-1.2	0.7
Arm fat percentage (left)	0.1	0.6	1.0	0.5	1.0	0.7
Average weekly red wine intake	0.4	0.7	1.2	-0.7	1.1	-0.6
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.8	-1.3	-0.3	-1.2
Mood swings	0.2	0.4	0.7	0.7	0.8	-0.1
Loneliness, isolation	1.5	2.1	2.6	-1.3	-1.6	-1.4
Long-standing illness, disability or infirmity	0.4	0.6	1.4	0.6	1.2	-0.3
Ever had bowel cancer screening	1.1	1.2	1.9	0.9	1.0	1.4
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.4	-0.1	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.2	0.8	0.5
Friendships satisfaction	0.4	0.6	1.4	-0.1	1.2	-0.5
Qualifications: nursing, teaching	0.1	0.2	0.3	0.0	0.6	0.4
Commuting to job workplace: Walk	0.6	0.6	1.1	-0.6	-0.6	1.1
Eye problems/disorders: Cataract	1.0	1.1	1.2	-1.1	1.1	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.2	-1.5	-0.9	-0.0
Medication for cholesterol	0.1	0.2	0.5	0.7	0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.1	1.4	0.3	1.5
Back pain experienced in last month	0.2	0.3	0.4	-0.4	-0.5	-0.6
Mineral and other dietary supplements	0.1	0.2	0.5	0.2	-0.1	-0.7
Breast cancer (self-reported)	0.6	0.7	1.2	-0.5	-1.1	-0.8
Asthma (self-reported)	0.5	1.0	1.8	0.0	1.1	-1.3
Osteoporosis (self-reported)	1.3	1.7	2.2	-1.2	-1.5	1.2
Osteoarthritis (self-reported)	0.6	0.8	1.2	1.1	1.1	-0.0
Medication: Aspirin	0.6	0.8	1.4	-1.2	0.1	1.1
Medication: Gliclazide	0.6	0.6	1.0	0.4	0.8	-1.0
Illnesses of father: None of the above (group 1)	0.1	0.2	0.5	0.1	0.2	0.7
Smoking status: Current	0.6	1.0	1.4	-1.2	-1.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	-0.3	-1.1	-0.6
Whole body water mass	0.1	0.7	1.5	0.4	-1.2	0.6
Leg predicted mass (right)	0.1	0.7	1.6	0.2	-1.2	0.6
Arm fat mass (left)	0.0	0.2	0.3	0.3	0.5	0.4
Number of self-reported non-cancer illnesses	0.4	0.7	1.2	1.1	0.9	0.1
Average weekly champagne plus white wine intake	0.7	1.0	2.6	-0.5	0.0	-1.6
Miserableness	1.0	1.7	4.0	-0.3	0.9	-2.0
Guilty feelings	2.5	3.8	4.3	-1.9	-1.9	-2.1
Wears glasses or contact lenses	1.4	1.6	3.7	-0.6	1.9	-0.9
Ever taken oral contraceptive pill	0.3	0.4	1.0	-0.3	0.0	-1.0
Hearing aid user	0.6	0.7	1.3	1.1	-0.7	0.5
Mother’s age at death	0.4	0.5	0.8	-0.7	-0.5	0.9
Financial situation satisfaction	0.0	0.1	0.1	-0.2	-0.4	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.3	-0.5	0.4	-0.5
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	0.3	0.1
Eye problems/disorders: Glaucoma	0.3	0.4	1.2	-0.0	0.1	-1.1
Medication: Blood pressure	0.1	0.2	0.5	-0.3	0.3	-0.7
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.5	1.3	0.7	-1.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.6	-0.5	0.0	1.3
High cholesterol (Self-reported)	2.6	4.6	8.2	2.9	0.3	2.4
Medication: Bendroflumethiazide	0.7	1.1	2.1	1.0	1.4	-0.2
Medication: Paracetamol	0.2	0.3	0.6	0.3	-0.5	-0.8
Medication: Lisinopril	1.2	1.6	4.6	0.3	0.4	2.1
Medication: Atorvastatin	0.1	0.2	0.5	0.7	0.2	-0.1
Illnesses of father: High blood pressure	0.3	0.4	0.9	-0.3	-0.4	0.9
Alcohol drinker status: Never	0.2	0.2	0.4	0.4	0.7	0.3
Ever smoked	0.2	0.4	1.1	-1.0	0.4	0.1
Basal metabolic rate	0.1	0.5	1.2	0.3	-1.1	0.6
Leg fat percentage (left)	0.1	0.2	0.3	-0.4	0.5	0.5
Arm fat-free mass (left)	0.1	0.6	1.5	0.5	-1.2	0.4
Number of operations (self-reported)	0.5	0.8	2.0	-1.4	0.4	-0.3
Average weekly beer plus cider intake	1.1	1.6	3.8	-1.9	-1.0	0.0
Irritability	3.3	5.6	13.5	0.2	1.8	-3.7
Risk taking	1.2	1.8	4.9	-0.6	-2.2	0.2
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.0	0.8	0.4	1.4
Fractured/broken bones in last 5 years	2.4	3.1	4.0	1.5	2.0	-1.7
Age started oral contraceptive pill	0.4	0.6	1.6	-0.2	0.0	-1.3
Diastolic blood pressure, automated reading	1.2	3.8	7.2	-2.0	0.5	-2.7
Ever depressed for a whole week	0.5	0.6	1.7	-1.3	-0.4	0.2
Unable to work because of sickness or disability	1.3	1.6	2.6	1.5	1.6	0.0
Commuting to job workplace: Cycle	0.5	0.6	1.7	1.3	0.2	0.4
Myopia	0.1	0.1	0.2	0.3	0.4	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.5	-0.5	-0.7	-0.6
Cholesterol lowering medication	0.2	0.3	0.6	-0.4	-0.3	0.8
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	5.5	-2.3	1.0	-2.1
Pain experienced in last month	0.2	0.3	0.7	-0.5	-0.3	0.8
Supplements: Calcium	1.8	2.0	3.3	-0.8	-1.4	1.8
Basal cell carcinoma (self-reported)	0.9	1.1	2.8	-0.5	-1.7	0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.4	-0.3	0.6	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	4.4	-0.6	-2.1	1.1
Heart disease (siblings)	0.7	0.8	1.9	1.4	0.7	0.4
Alcohol drinker status: Previous	0.8	0.9	1.6	1.3	0.0	1.1
Pack years of smoking	0.8	1.2	2.2	1.5	0.3	1.1
Impedance of whole body	0.1	0.7	1.4	-1.2	-0.7	0.2
Leg fat mass (left)	0.0	0.2	0.3	-0.5	-0.2	0.5
Arm predicted mass (left)	0.1	0.5	1.2	0.4	-1.1	0.3