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chr11:60,465,487-63,110,149

Best TWAS P=5.23e-38 · Best GWAS P=1.32e-38 conditioned to 0.0258

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	12.79	-12.8	1.7e-37	-0.96	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	12.79	12.8	1.3e-37	0.95	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	ROM1	0.25	0.17	lasso	3	0.18	1.5e-14	-5.17	5.5	4.2e-08	0.05	0.03	0.97	FALSE
4	GTEx	Adipose Visceral Omentum	ROM1	0.29	0.16	lasso	8	0.23	3.7e-12	-5.37	5.6	2.7e-08	0.03	0.03	0.97	FALSE
5	GTEx	Adrenal Gland	INCENP	0.23	0.05	lasso	3	0.03	3.8e-02	-4.43	-5.4	5.2e-08	-0.43	0.07	0.09	FALSE
6	GTEx	Artery Aorta	FADS2	0.18	0.17	lasso	3	0.14	3.2e-08	5.46	6.9	6.3e-12	0.66	0.38	0.61	FALSE
7	GTEx	Artery Aorta	ROM1	0.18	0.17	lasso	7	0.16	3.3e-09	-5.53	5.5	3.7e-08	0.04	0.02	0.98	FALSE
8	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	11.84	9.9	2.5e-23	0.77	0.03	0.94	FALSE
9	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	12.65	12.7	6.0e-37	0.93	0.04	0.95	FALSE
10	GTEx	Artery Tibial	FADS1	0.09	0.00	enet	29	0.01	7.0e-02	-0.68	-6.5	7.4e-11	-0.45	0.06	0.36	FALSE
11	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	12.10	-12.1	8.9e-34	-0.92	0.01	0.99	FALSE
12	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	12.06	-12.6	1.7e-36	-0.90	0.05	0.74	FALSE
13	GTEx	Brain Putamen basal ganglia	FADS1	0.29	0.21	enet	30	0.16	1.4e-04	12.79	-10.5	1.0e-25	-0.77	0.02	0.92	FALSE
14	GTEx	Breast Mammary Tissue	ROM1	0.10	0.09	lasso	5	0.06	5.4e-04	-5.53	5.6	2.2e-08	0.04	0.02	0.98	FALSE
15	GTEx	Breast Mammary Tissue (Female)	TMEM258	0.20	0.02	lasso	7	0.00	2.3e-01	8.40	10.6	2.6e-26	0.74	0.05	0.38	FALSE
16	GTEx	Breast Mammary Tissue (Female)	ROM1	0.16	0.02	lasso	4	0.04	2.9e-02	-5.37	5.4	5.2e-08	0.02	0.02	0.85	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	EML3	0.33	0.22	lasso	8	0.21	1.6e-07	-5.45	-5.3	1.0e-07	-0.04	0.02	0.97	FALSE
18	GTEx	Cells Transformed fibroblasts	FADS2	0.20	0.23	lasso	3	0.23	4.6e-17	5.46	5.6	1.7e-08	0.59	1.00	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	11.84	9.5	1.7e-21	0.78	0.02	0.98	FALSE
20	GTEx	Cells Transformed fibroblasts	MTA2	0.06	0.09	lasso	1	0.07	3.0e-06	-5.71	-5.7	1.1e-08	-0.03	0.01	0.99	FALSE
21	GTEx	Cells Transformed fibroblasts	EML3	0.19	0.16	lasso	9	0.18	7.3e-14	-5.74	-5.8	5.6e-09	-0.05	0.01	0.99	TRUE
22	GTEx	Colon Sigmoid	FADS2	0.24	0.12	lasso	5	0.13	2.2e-05	5.31	7.2	7.6e-13	0.51	0.19	0.50	FALSE
23	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	5.46	8.8	1.8e-18	0.73	0.08	0.92	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	FADS2	0.22	0.22	lasso	2	0.20	7.8e-08	5.46	5.3	1.5e-07	0.56	0.42	0.46	FALSE
25	GTEx	Esophagus Mucosa	MTA2	0.29	0.34	lasso	5	0.33	6.9e-23	-5.45	-5.5	4.8e-08	-0.05	0.02	0.98	FALSE
26	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	12.99	-12.9	5.2e-38	-0.94	0.01	0.98	TRUE
27	GTEx	Esophagus Mucosa	EML3	0.40	0.43	lasso	8	0.46	1.8e-33	-5.58	-5.6	2.5e-08	-0.04	0.02	0.98	FALSE
28	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	5.46	7.4	1.3e-13	0.69	1.00	0.00	FALSE
29	GTEx	Heart Atrial Appendage	FADS2	0.16	0.11	lasso	1	0.04	5.1e-03	5.46	5.5	4.8e-08	0.57	0.09	0.81	FALSE
30	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	7.31	7.8	7.3e-15	0.69	0.47	0.52	FALSE
31	GTEx	Lung	ROM1	0.25	0.18	enet	13	0.20	2.2e-15	-5.45	5.7	1.0e-08	0.04	0.02	0.98	FALSE
32	GTEx	Lung	EML3	0.07	0.04	lasso	3	0.01	2.5e-02	-5.43	-5.5	3.6e-08	-0.05	0.02	0.94	FALSE
33	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	12.14	11.1	1.5e-28	0.87	0.11	0.88	FALSE
34	GTEx	Nerve Tibial	FADS2	0.20	0.14	lasso	3	0.13	1.5e-09	5.46	5.6	2.5e-08	0.58	0.93	0.07	FALSE
35	GTEx	Nerve Tibial	EML3	0.17	0.10	lasso	4	0.09	3.9e-07	-5.43	-5.3	1.1e-07	-0.05	0.04	0.96	FALSE
36	GTEx	Ovary	ROM1	0.25	0.00	lasso	5	0.00	3.3e-01	-5.71	5.7	1.5e-08	0.04	0.02	0.79	FALSE
37	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	12.06	-12.4	2.2e-35	-0.89	0.02	0.98	FALSE
38	GTEx	Pancreas	TMEM216	0.17	-0.01	lasso	3	0.01	1.4e-01	-2.08	-5.8	6.1e-09	-0.21	0.07	0.09	TRUE
39	GTEx	Skin Not Sun Exposed Suprapubic	ROM1	0.15	0.08	lasso	1	0.06	2.8e-04	-5.20	5.2	2.0e-07	0.04	0.03	0.82	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	EML3	0.20	0.19	lasso	3	0.24	2.7e-13	-5.43	-5.2	1.7e-07	-0.05	0.04	0.96	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	B3GAT3	0.18	0.11	lasso	3	0.11	9.8e-07	-5.09	-5.5	3.6e-08	-0.04	0.04	0.96	FALSE
42	GTEx	Skin Sun Exposed Lower leg	MTA2	0.14	0.04	enet	21	0.05	3.1e-05	-5.17	-5.7	9.2e-09	-0.10	0.04	0.94	FALSE
43	GTEx	Skin Sun Exposed Lower leg	ROM1	0.13	0.11	lasso	4	0.10	9.7e-09	-5.45	5.5	4.5e-08	0.06	0.02	0.97	FALSE
44	GTEx	Skin Sun Exposed Lower leg	EML3	0.32	0.25	enet	19	0.26	8.0e-22	-5.43	-5.3	1.1e-07	-0.03	0.03	0.97	FALSE
45	GTEx	Spleen	MYRF	0.23	0.00	lasso	4	-0.01	4.6e-01	6.76	6.0	1.4e-09	0.53	0.04	0.37	FALSE
46	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	5.46	7.5	5.9e-14	0.70	0.10	0.88	FALSE
47	GTEx	Stomach	EML3	0.11	0.04	enet	5	0.03	2.1e-02	-5.61	-5.6	1.9e-08	-0.06	0.02	0.84	FALSE
48	GTEx	Testis	EML3	0.27	0.22	enet	15	0.29	2.7e-13	-5.45	-5.7	1.0e-08	-0.05	0.02	0.98	FALSE
49	GTEx	Thyroid	FADS2	0.16	0.18	lasso	4	0.17	7.0e-13	5.46	5.7	1.4e-08	0.58	1.00	0.00	FALSE
50	GTEx	Thyroid	ROM1	0.17	0.16	lasso	8	0.16	3.6e-12	-5.42	5.4	5.4e-08	0.05	0.03	0.97	FALSE
51	GTEx	Thyroid	EML3	0.10	0.11	lasso	4	0.10	5.9e-08	-5.43	-5.4	7.2e-08	-0.06	0.03	0.97	FALSE
52	GTEx	Uterus	PPP1R32	0.66	-0.01	lasso	13	0.14	8.8e-04	0.83	6.7	1.6e-11	0.59	0.02	0.52	FALSE
53	GTEx	Whole Blood	FADS2	0.49	0.48	lasso	5	0.48	3.0e-49	5.46	5.8	8.5e-09	0.59	1.00	0.00	FALSE
54	GTEx	Whole Blood	EML3	0.17	0.09	lasso	7	0.08	6.3e-08	-5.53	-5.7	1.6e-08	-0.04	0.02	0.98	FALSE
55	METSIM	Adipose	EML3	0.15	0.14	bslmm	376	0.14	1.9e-20	-5.54	-5.3	1.3e-07	-0.03	0.02	0.98	FALSE
56	METSIM	Adipose	FADS2	0.07	0.05	lasso	3	0.04	3.2e-07	5.46	5.2	1.8e-07	0.53	0.98	0.01	FALSE
57	METSIM	Adipose	TMEM258	0.04	0.00	bslmm	407	0.01	4.1e-02	12.06	9.2	5.1e-20	0.61	0.04	0.82	FALSE
58	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	11.84	12.4	4.1e-35	0.89	0.09	0.91	FALSE
59	NTR	Blood	FADS2	0.30	0.33	lasso	7	0.33	9.0e-109	5.46	6.2	4.9e-10	0.62	1.00	0.00	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	11.84	12.3	5.2e-35	0.93	0.01	0.99	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	12.66	-12.8	1.7e-37	-0.96	0.01	0.99	FALSE
62	YFS	Blood	EEF1G	0.30	0.45	lasso	6	0.45	3.6e-166	-5.53	5.5	3.3e-08	0.04	0.02	0.98	FALSE
63	YFS	Blood	EML3	0.20	0.31	lasso	12	0.33	1.3e-110	-5.23	-5.4	6.3e-08	-0.05	0.04	0.96	FALSE
64	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	5.46	8.7	2.4e-18	0.75	1.00	0.00	FALSE
65	YFS	Blood	INTS5	0.09	0.12	lasso	4	0.12	1.9e-38	-5.09	-5.5	3.6e-08	-0.04	0.14	0.86	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EEF1G	0.04	0.05	lasso	1	0.04	1.1e-04	-5.17	5.2	2.3e-07	0.06	0.03	0.94	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	EEF1G	0.02	0.04	lasso	2	0.03	6.3e-07	-5.58	5.6	2.4e-08	0.04	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	EML3	0.02	0.02	lasso	4	0.02	2.5e-05	-5.23	-5.2	1.5e-07	-0.05	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS1	0.04	0.00	blup	53	0.01	1.4e-03	4.09	-8.2	3.7e-16	-0.57	0.02	0.25	FALSE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS2	0.05	0.04	lasso	2	0.04	2.2e-09	5.46	5.9	3.7e-09	0.55	0.97	0.03	FALSE
71	The Cancer Genome Atlas	Breast Invasive Carcinoma	ROM1	0.01	0.02	enet	4	0.02	2.4e-04	-5.17	5.1	2.8e-07	0.04	0.02	0.94	FALSE
72	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	12.06	-10.2	1.3e-24	-0.69	0.02	0.67	FALSE
73	The Cancer Genome Atlas	Colon Adenocarcinoma	EEF1G	0.07	0.11	lasso	1	0.11	9.2e-07	-5.45	5.5	5.1e-08	0.03	0.02	0.98	FALSE
74	The Cancer Genome Atlas	Colon Adenocarcinoma	EML3	0.07	0.03	blup	29	0.05	6.5e-04	-5.71	-5.6	2.6e-08	-0.06	0.01	0.91	FALSE
75	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	5.46	8.2	1.7e-16	0.74	0.66	0.34	FALSE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EEF1G	0.10	0.09	blup	26	0.09	9.8e-11	-5.45	5.6	2.2e-08	0.06	0.02	0.98	FALSE
77	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FADS2	0.05	0.04	lasso	3	0.05	1.9e-06	5.46	8.1	7.7e-16	0.68	0.13	0.84	FALSE
78	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ROM1	0.04	0.02	blup	22	0.02	6.2e-03	-5.71	5.4	8.3e-08	0.03	0.01	0.88	FALSE
79	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EEF1G	0.11	0.12	blup	27	0.13	5.5e-14	-5.45	5.4	7.2e-08	0.04	0.02	0.98	FALSE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EML3	0.04	0.06	lasso	3	0.06	1.7e-07	-5.43	-5.4	5.5e-08	-0.05	0.02	0.98	FALSE
81	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	5.46	8.2	2.4e-16	0.71	1.00	0.00	FALSE
82	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EEF1G	0.07	0.04	blup	28	0.07	9.8e-05	-5.71	5.5	3.9e-08	0.02	0.01	0.95	FALSE
83	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	5.46	8.7	3.3e-18	0.77	0.61	0.39	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	EEF1G	0.06	0.07	blup	27	0.07	8.1e-09	-5.54	5.4	6.5e-08	0.04	0.02	0.98	FALSE
85	The Cancer Genome Atlas	Brain Lower Grade Glioma	EML3	0.03	0.04	blup	28	0.03	7.6e-05	-5.23	-5.5	2.8e-08	-0.06	0.02	0.97	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	10.95	-11.0	3.4e-28	-0.84	0.04	0.95	FALSE
87	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EEF1G	0.06	0.03	blup	27	0.04	4.5e-03	-4.62	5.5	4.6e-08	0.03	0.01	0.73	FALSE
88	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FADS1	0.20	0.01	blup	51	0.07	3.2e-04	12.63	-11.8	3.6e-32	-0.83	0.01	0.94	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	EEF1G	0.06	0.08	lasso	8	0.08	5.9e-10	-5.54	5.8	7.7e-09	0.04	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Lung Adenocarcinoma	EML3	0.03	0.03	blup	28	0.03	8.4e-05	-5.54	-5.6	2.6e-08	-0.05	0.02	0.98	FALSE
91	The Cancer Genome Atlas	Lung Adenocarcinoma	FADS2	0.04	0.04	lasso	4	0.02	1.7e-03	5.46	6.2	7.2e-10	0.61	0.03	0.88	FALSE
92	The Cancer Genome Atlas	Lung Adenocarcinoma	ROM1	0.04	0.04	blup	23	0.04	9.5e-06	-5.58	5.7	1.3e-08	0.05	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EEF1G	0.08	0.13	lasso	4	0.12	3.1e-13	-5.53	5.5	3.1e-08	0.04	0.02	0.98	FALSE
94	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EML3	0.04	0.05	blup	27	0.05	3.5e-06	-5.17	-5.7	1.4e-08	-0.07	0.02	0.97	FALSE
95	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	12.14	11.7	1.5e-31	0.86	0.04	0.66	FALSE
96	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EML3	0.03	0.02	blup	27	0.03	3.5e-03	-5.17	-5.5	3.3e-08	-0.04	0.02	0.75	FALSE
97	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EEF1G	0.08	0.08	blup	27	0.05	3.6e-03	-5.54	5.4	7.3e-08	0.06	0.02	0.93	FALSE
98	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FADS2	0.15	0.16	lasso	2	0.12	8.8e-06	5.46	6.0	1.8e-09	0.57	0.47	0.31	FALSE
99	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EEF1G	0.08	0.00	blup	27	0.04	1.3e-02	-5.54	5.8	8.8e-09	0.07	0.02	0.82	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf10	0.02	0.01	enet	11	0.01	1.6e-02	11.84	8.5	2.5e-17	0.77	0.01	0.74	FALSE
101	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf83	0.03	0.03	blup	24	0.02	5.5e-03	-5.26	5.3	9.7e-08	0.06	0.00	0.98	FALSE
102	The Cancer Genome Atlas	Prostate Adenocarcinoma	EEF1G	0.08	0.13	lasso	2	0.12	1.8e-12	-5.55	5.6	2.8e-08	0.04	0.02	0.98	FALSE
103	The Cancer Genome Atlas	Prostate Adenocarcinoma	EML3	0.09	0.14	lasso	1	0.14	3.4e-14	-5.17	-5.2	2.3e-07	-0.06	0.07	0.93	FALSE
104	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS1	0.06	0.04	blup	53	0.03	2.0e-04	12.10	-9.4	8.0e-21	-0.72	0.04	0.70	FALSE
105	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS2	0.07	0.07	lasso	4	0.06	1.9e-06	5.46	7.3	2.2e-13	0.69	0.31	0.65	FALSE
106	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	5.46	7.1	1.1e-12	0.66	0.04	0.94	FALSE
107	The Cancer Genome Atlas	Soft Tissue Sarcoma	ROM1	0.06	0.05	blup	24	0.03	8.1e-03	-5.58	5.3	9.2e-08	0.04	0.01	0.86	FALSE
108	The Cancer Genome Atlas	Skin Cutaneous Melanoma	EML3	0.32	0.03	lasso	2	0.07	4.9e-03	-5.61	-5.2	2.6e-07	-0.03	0.01	0.66	FALSE
109	The Cancer Genome Atlas	Stomach Adenocarcinoma	EEF1G	0.05	0.07	blup	27	0.07	1.7e-05	-5.45	5.7	1.6e-08	0.05	0.02	0.98	FALSE
110	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	5.46	9.1	1.3e-19	0.69	0.06	0.94	FALSE
111	The Cancer Genome Atlas	Stomach Adenocarcinoma	ROM1	0.05	0.08	lasso	3	0.08	3.1e-06	-5.43	5.6	2.3e-08	0.06	0.01	0.99	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	10.82	12.1	5.8e-34	0.94	0.02	0.62	FALSE
113	The Cancer Genome Atlas	Thyroid Carcinoma	EML3	0.11	0.10	blup	28	0.12	2.3e-11	-5.17	-5.2	1.6e-07	-0.05	0.10	0.89	FALSE
114	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	5.46	7.7	1.0e-14	0.69	1.00	0.00	FALSE
115	The Cancer Genome Atlas	Thyroid Carcinoma	ROM1	0.03	0.02	blup	23	0.02	1.1e-02	-5.45	5.3	1.4e-07	0.04	0.02	0.89	FALSE