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chr3:49,016,056-50,932,324

Best TWAS P=2.41e-10 · Best GWAS P=9.96e-10 conditioned to 0.0432

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RBM6	0.25	0.35	lasso	9	0.35	1.8e-29	-5.3	-5.6	1.7e-08	-0.64	0.43	0.57	FALSE
2	GTEx	Adipose Subcutaneous	RNF123	0.19	0.18	enet	29	0.18	2.1e-14	5.5	5.8	5.5e-09	0.59	0.18	0.82	FALSE
3	GTEx	Adipose Visceral Omentum	RBM6	0.20	0.28	enet	30	0.30	6.4e-16	-5.2	-5.6	2.7e-08	-0.70	0.43	0.57	FALSE
4	GTEx	Adipose Visceral Omentum	RNF123	0.08	0.11	lasso	4	0.07	2.2e-04	5.6	5.6	1.8e-08	0.51	0.18	0.79	FALSE
5	GTEx	Adrenal Gland	RBM6	0.12	0.05	enet	18	0.05	5.9e-03	-5.3	-5.2	2.2e-07	-0.67	0.26	0.62	FALSE
6	GTEx	Artery Aorta	RBM6	0.32	0.36	lasso	6	0.41	3.3e-24	-5.2	-5.6	2.6e-08	-0.73	0.43	0.57	FALSE
7	GTEx	Artery Aorta	APEH	0.05	0.03	enet	8	0.01	9.1e-02	-4.8	-5.7	1.3e-08	-0.74	0.06	0.86	FALSE
8	GTEx	Artery Aorta	UBA7	0.06	0.02	enet	12	0.01	5.3e-02	5.3	-5.6	2.2e-08	-0.67	0.17	0.59	FALSE
9	GTEx	Artery Coronary	RBM6	0.14	0.14	enet	23	0.15	1.0e-05	5.4	-6.1	1.1e-09	-0.68	0.20	0.79	FALSE
10	GTEx	Artery Tibial	RBM6	0.24	0.31	enet	24	0.30	5.8e-24	-5.2	-5.5	3.0e-08	-0.69	0.48	0.52	FALSE
11	GTEx	Artery Tibial	RNF123	0.08	0.08	enet	12	0.09	2.5e-07	5.5	5.5	2.8e-08	0.46	0.18	0.82	FALSE
12	GTEx	Artery Tibial	UBA7	0.04	0.03	lasso	4	0.02	7.8e-03	-5.5	-5.7	1.2e-08	-0.81	0.12	0.44	FALSE
13	GTEx	Brain Caudate basal ganglia	RBM6	0.20	0.14	enet	16	0.11	5.5e-04	-3.2	-5.5	4.1e-08	-0.69	0.15	0.79	FALSE
14	GTEx	Brain Caudate basal ganglia	RNF123	0.13	0.04	enet	20	0.02	1.2e-01	5.5	5.6	2.4e-08	0.53	0.14	0.50	FALSE
15	GTEx	Brain Cerebellar Hemisphere	RBM6	0.19	0.28	lasso	5	0.32	7.4e-09	5.3	-5.5	3.4e-08	-0.61	0.35	0.63	FALSE
16	GTEx	Brain Cerebellar Hemisphere	RNF123	0.20	0.24	enet	29	0.20	7.7e-06	5.5	5.3	1.1e-07	0.47	0.18	0.74	FALSE
17	GTEx	Brain Cerebellum	RBM6	0.25	0.41	enet	32	0.33	2.1e-10	-5.3	-5.4	6.0e-08	-0.70	0.27	0.73	FALSE
18	GTEx	Brain Cerebellum	RNF123	0.36	0.31	enet	43	0.36	2.4e-11	5.5	5.4	5.2e-08	0.57	0.18	0.82	FALSE
19	GTEx	Brain Cerebellum	MST1R	0.19	0.24	enet	22	0.20	1.8e-06	-5.0	5.8	9.0e-09	0.70	0.17	0.83	FALSE
20	GTEx	Brain Cerebellum	FAM212A	0.27	0.35	lasso	5	0.34	9.7e-11	5.6	5.6	2.0e-08	0.50	0.18	0.82	FALSE
21	GTEx	Brain Cortex	RNF123	0.23	0.05	enet	33	0.04	2.4e-02	5.5	5.3	8.6e-08	0.49	0.13	0.50	FALSE
22	GTEx	Brain Frontal Cortex BA9	RBM6	0.18	0.25	lasso	3	0.20	5.2e-06	5.3	5.4	6.7e-08	0.58	0.34	0.61	FALSE
23	GTEx	Brain Frontal Cortex BA9	RNF123	0.25	0.28	enet	34	0.05	2.3e-02	5.5	5.7	1.4e-08	0.62	0.18	0.80	FALSE
24	GTEx	Brain Nucleus accumbens basal ganglia	RBM6	0.20	0.19	enet	29	0.22	2.0e-06	-5.2	-5.6	1.8e-08	-0.57	0.25	0.72	FALSE
25	GTEx	Brain Putamen basal ganglia	RBM6	0.15	0.22	lasso	4	0.12	7.4e-04	-5.3	-5.3	1.4e-07	-0.66	0.18	0.71	FALSE
26	GTEx	Breast Mammary Tissue	RBM6	0.25	0.35	enet	26	0.38	7.4e-21	-4.8	-5.3	1.0e-07	-0.69	0.47	0.53	FALSE
27	GTEx	Breast Mammary Tissue	RNF123	0.11	0.07	enet	14	0.02	3.2e-02	5.5	5.4	7.2e-08	0.55	0.19	0.73	FALSE
28	GTEx	Breast Mammary Tissue (Female)	RBM6	0.23	0.27	enet	16	0.26	2.7e-08	5.4	-5.3	1.1e-07	-0.65	0.44	0.56	FALSE
29	GTEx	Cells EBV-transformed lymphocytes	RBM6	0.27	0.21	enet	14	0.23	5.0e-08	-5.3	-5.2	2.0e-07	-0.64	0.48	0.52	FALSE
30	GTEx	Cells Transformed fibroblasts	UBA7	0.07	0.06	enet	5	0.04	7.5e-04	5.4	-5.4	7.4e-08	-0.50	0.22	0.77	FALSE
31	GTEx	Colon Sigmoid	RBM6	0.25	0.19	enet	7	0.13	2.3e-05	-5.2	-5.3	1.2e-07	-0.64	0.44	0.56	FALSE
32	GTEx	Colon Sigmoid	RNF123	0.22	0.10	enet	23	0.20	1.1e-07	3.6	5.2	1.9e-07	0.54	0.30	0.68	FALSE
33	GTEx	Colon Transverse	UBA7	0.28	0.30	lasso	2	0.30	1.1e-14	5.5	-5.5	2.9e-08	-0.51	0.18	0.82	FALSE
34	GTEx	Esophagus Gastroesophageal Junction	RBM6	0.25	0.29	lasso	23	0.30	2.2e-11	-4.6	-5.6	1.9e-08	-0.61	0.37	0.63	FALSE
35	GTEx	Esophagus Mucosa	UBA7	0.04	0.07	enet	8	0.05	4.5e-04	5.5	-5.6	2.4e-08	-0.54	0.19	0.76	FALSE
36	GTEx	Esophagus Mucosa	FAM212A	0.19	0.26	enet	24	0.27	4.4e-18	5.5	5.5	4.0e-08	0.51	0.18	0.82	FALSE
37	GTEx	Esophagus Muscularis	RBM6	0.22	0.29	lasso	7	0.30	1.1e-18	-5.2	-5.3	1.2e-07	-0.70	0.50	0.50	FALSE
38	GTEx	Esophagus Muscularis	RNF123	0.15	0.14	enet	17	0.14	1.2e-08	5.3	5.5	4.0e-08	0.50	0.17	0.83	FALSE
39	GTEx	Esophagus Muscularis	MST1R	0.05	0.00	lasso	5	0.05	3.6e-04	-5.3	5.2	1.8e-07	0.58	0.15	0.56	FALSE
40	GTEx	Heart Atrial Appendage	RBM6	0.34	0.36	lasso	6	0.35	1.2e-16	-5.2	-5.5	4.1e-08	-0.68	0.38	0.62	FALSE
41	GTEx	Heart Atrial Appendage	MST1R	0.08	0.00	enet	22	0.03	1.5e-02	4.9	6.3	2.4e-10	0.76	0.07	0.78	TRUE
42	GTEx	Heart Left Ventricle	RBM6	0.09	0.08	enet	10	0.11	3.0e-06	-5.0	-5.6	1.8e-08	-0.73	0.15	0.85	FALSE
43	GTEx	Liver	RBM6	0.21	0.11	enet	6	0.09	1.4e-03	5.3	-5.5	3.3e-08	-0.66	0.19	0.63	FALSE
44	GTEx	Lung	RBM6	0.17	0.20	lasso	6	0.24	4.6e-18	-5.0	-5.5	3.2e-08	-0.69	0.46	0.54	FALSE
45	GTEx	Lung	RNF123	0.13	0.05	enet	18	0.07	5.8e-06	5.3	5.1	3.1e-07	0.49	0.21	0.77	FALSE
46	GTEx	Lung	MST1R	0.06	0.04	lasso	3	0.04	7.5e-04	-5.0	5.3	1.1e-07	0.62	0.21	0.63	FALSE
47	GTEx	Muscle Skeletal	RBM6	0.11	0.15	enet	13	0.15	3.1e-14	-4.8	-5.6	2.7e-08	-0.74	0.46	0.54	FALSE
48	GTEx	Nerve Tibial	RBM6	0.41	0.42	enet	19	0.41	8.8e-31	-5.2	-5.2	1.9e-07	-0.67	0.52	0.48	FALSE
49	GTEx	Nerve Tibial	RNF123	0.24	0.16	lasso	5	0.15	1.0e-10	5.4	5.5	3.7e-08	0.52	0.19	0.81	FALSE
50	GTEx	Pituitary	RBM6	0.27	0.21	enet	22	0.19	1.5e-05	-5.0	-6.1	1.3e-09	-0.84	0.09	0.90	FALSE
51	GTEx	Prostate	RBM6	0.14	0.12	enet	15	0.05	1.8e-02	-5.3	-5.3	1.2e-07	-0.66	0.19	0.48	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	RBM6	0.16	0.17	enet	24	0.23	1.2e-12	-4.6	-5.6	1.7e-08	-0.72	0.21	0.79	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	MST1R	0.05	0.07	enet	7	0.05	7.1e-04	-5.3	5.2	1.7e-07	0.65	0.31	0.56	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	FAM212A	0.05	0.04	enet	21	0.01	1.1e-01	-5.3	5.4	7.1e-08	0.65	0.24	0.59	FALSE
55	GTEx	Skin Sun Exposed Lower leg	RBM6	0.23	0.27	lasso	8	0.29	7.6e-24	-5.3	-5.2	2.2e-07	-0.66	0.47	0.53	FALSE
56	GTEx	Skin Sun Exposed Lower leg	MST1R	0.06	0.07	lasso	2	0.06	1.1e-05	5.4	5.4	6.0e-08	0.57	0.23	0.72	FALSE
57	GTEx	Skin Sun Exposed Lower leg	UBA7	0.04	0.01	lasso	8	0.00	2.9e-01	5.5	-5.5	4.4e-08	-0.56	0.12	0.43	FALSE
58	GTEx	Skin Sun Exposed Lower leg	FAM212A	0.05	0.07	enet	16	0.06	1.1e-05	5.5	5.5	2.9e-08	0.50	0.17	0.83	FALSE
59	GTEx	Small Intestine Terminal Ileum	MST1R	0.20	0.05	lasso	5	0.10	3.6e-03	5.7	5.8	6.4e-09	0.74	0.06	0.75	FALSE
60	GTEx	Spleen	RBM6	0.36	0.39	lasso	8	0.40	2.0e-11	-4.8	-5.1	2.9e-07	-0.74	0.49	0.50	FALSE
61	GTEx	Spleen	RNF123	0.13	0.13	lasso	5	0.10	1.3e-03	5.5	5.5	3.8e-08	0.50	0.12	0.46	FALSE
62	GTEx	Spleen	UBA7	0.19	0.14	lasso	22	0.11	8.8e-04	5.3	-5.3	9.8e-08	-0.52	0.16	0.69	FALSE
63	GTEx	Stomach	RBM6	0.16	0.22	lasso	11	0.19	2.1e-09	-5.2	-5.2	2.0e-07	-0.66	0.47	0.53	FALSE
64	GTEx	Stomach	RNF123	0.23	0.12	lasso	15	0.16	4.6e-08	3.6	5.2	1.7e-07	0.54	0.39	0.60	FALSE
65	GTEx	Testis	RBM6	0.28	0.14	enet	19	0.17	7.7e-08	5.3	-5.5	3.4e-08	-0.64	0.05	0.95	FALSE
66	GTEx	Testis	MON1A	0.08	0.06	enet	13	0.05	2.4e-03	5.7	-6.2	5.0e-10	-0.71	0.07	0.84	FALSE
67	GTEx	Thyroid	RBM6	0.25	0.35	lasso	15	0.36	1.9e-28	-5.2	-5.7	1.3e-08	-0.72	0.44	0.56	FALSE
68	GTEx	Thyroid	RNF123	0.09	0.13	lasso	9	0.12	2.7e-09	5.4	5.5	3.9e-08	0.50	0.18	0.82	FALSE
69	GTEx	Thyroid	MST1R	0.06	0.06	enet	9	0.05	1.7e-04	5.3	5.7	1.3e-08	0.58	0.27	0.72	FALSE
70	GTEx	Whole Blood	RBM6	0.14	0.19	lasso	3	0.18	2.4e-16	-5.2	-5.1	3.0e-07	-0.67	0.54	0.46	FALSE
71	GTEx	Whole Blood	UBA7	0.03	0.04	lasso	2	0.01	1.5e-02	5.5	-5.7	1.2e-08	-0.57	0.15	0.70	FALSE
72	METSIM	Adipose	MST1R	0.03	0.02	blup	331	0.02	1.7e-03	5.3	6.0	2.0e-09	0.75	0.04	0.95	FALSE
73	METSIM	Adipose	RNF123	0.03	0.02	lasso	12	0.02	2.0e-04	5.3	5.5	4.4e-08	0.47	0.19	0.79	FALSE
74	NTR	Blood	RBM6	0.06	0.14	enet	36	0.13	7.9e-40	-5.3	-5.5	3.0e-08	-0.71	0.47	0.53	FALSE
75	NTR	Blood	UBA7	0.02	0.03	lasso	4	0.03	1.6e-09	5.4	-5.5	3.2e-08	-0.54	0.21	0.79	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	SEMA3F	0.07	0.11	bslmm	275	0.10	4.9e-13	5.3	-5.2	2.1e-07	-0.80	0.22	0.78	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	RNF123	0.04	0.05	lasso	3	0.05	1.4e-06	5.4	5.6	2.5e-08	0.54	0.19	0.81	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	MST1R	0.02	0.00	blup	278	0.01	4.5e-02	5.3	5.6	1.8e-08	0.62	0.26	0.63	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	SLC38A3	0.03	0.03	lasso	5	0.02	6.4e-04	5.4	-5.5	3.1e-08	-0.82	0.04	0.95	FALSE
80	YFS	Blood	RBM6	0.28	0.43	enet	57	0.44	4.0e-160	-5.3	-5.2	2.2e-07	-0.64	0.46	0.54	FALSE
81	YFS	Blood	UBA7	0.16	0.24	lasso	6	0.23	4.0e-75	5.4	-5.3	8.6e-08	-0.49	0.27	0.73	FALSE
82	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RBM6	0.06	0.09	enet	27	0.10	9.3e-09	-5.3	-5.2	1.5e-07	-0.69	0.17	0.83	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	UBA7	0.01	0.01	enet	5	0.01	6.6e-04	5.3	-5.4	5.2e-08	-0.46	0.04	0.94	FALSE
84	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RBM6	0.09	0.13	blup	79	0.12	1.6e-06	-5.0	-5.5	4.5e-08	-0.71	0.13	0.87	FALSE
85	The Cancer Genome Atlas	Colon Adenocarcinoma	UBA7	0.11	0.06	enet	5	0.05	7.6e-04	5.3	-5.2	2.5e-07	-0.41	0.04	0.96	FALSE
86	The Cancer Genome Atlas	Glioblastoma Multiforme	RBM6	0.22	0.03	enet	32	0.04	3.1e-02	5.3	-5.2	1.7e-07	-0.66	0.04	0.85	FALSE
87	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RBM6	0.04	0.05	blup	79	0.05	2.0e-06	5.4	-5.5	3.6e-08	-0.72	0.03	0.97	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBA7	0.02	0.02	blup	30	0.02	3.8e-03	5.5	-5.8	6.6e-09	-0.59	0.02	0.72	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MST1R	0.03	0.04	blup	32	0.05	4.0e-06	5.4	5.9	3.3e-09	0.68	0.05	0.94	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RBM6	0.09	0.11	blup	79	0.11	3.8e-12	-5.3	-5.2	2.1e-07	-0.68	0.20	0.80	FALSE
91	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBA7	0.08	0.09	lasso	5	0.09	3.4e-10	5.4	-5.4	6.2e-08	-0.51	0.04	0.96	FALSE
92	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RBM6	0.14	0.17	lasso	5	0.17	5.7e-10	5.4	-5.3	1.3e-07	-0.63	0.20	0.80	FALSE
93	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UBA7	0.13	0.16	lasso	6	0.15	1.1e-08	5.3	-5.5	3.9e-08	-0.51	0.03	0.97	FALSE
94	The Cancer Genome Atlas	Brain Lower Grade Glioma	RBM6	0.10	0.14	enet	17	0.14	7.7e-16	-5.3	-5.1	2.8e-07	-0.65	0.20	0.80	FALSE
95	The Cancer Genome Atlas	Brain Lower Grade Glioma	RNF123	0.07	0.05	enet	19	0.05	3.1e-06	5.5	5.3	1.5e-07	0.53	0.02	0.98	FALSE
96	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEMA3F	0.02	0.04	lasso	3	0.03	2.3e-04	-5.5	-5.7	9.2e-09	-0.91	0.01	0.92	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRAIP	0.02	0.01	enet	8	0.01	3.1e-02	3.4	5.1	3.0e-07	0.51	0.02	0.56	FALSE
98	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RBM6	0.09	0.07	blup	79	0.08	1.3e-04	-4.9	-5.3	1.1e-07	-0.72	0.04	0.95	FALSE
99	The Cancer Genome Atlas	Lung Adenocarcinoma	AMIGO3	0.02	0.00	blup	40	0.00	3.0e-01	5.5	5.6	2.0e-08	0.53	0.01	0.81	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	UBA7	0.03	0.04	enet	9	0.02	1.8e-03	5.3	-5.4	6.9e-08	-0.50	0.04	0.96	FALSE
101	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RBM6	0.05	0.06	lasso	10	0.04	9.1e-06	-5.3	-5.2	1.6e-07	-0.65	0.21	0.79	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBA7	0.02	0.01	blup	30	0.02	5.3e-03	5.3	-5.5	4.3e-08	-0.52	0.02	0.84	FALSE
103	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMPPB	0.04	0.02	blup	40	0.02	1.4e-02	5.5	5.5	3.8e-08	0.54	0.01	0.71	FALSE
104	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UBA7	0.11	0.14	enet	7	0.11	2.7e-05	5.3	-5.4	5.7e-08	-0.51	0.03	0.95	FALSE
105	The Cancer Genome Atlas	Prostate Adenocarcinoma	RBM6	0.09	0.15	enet	16	0.15	1.1e-15	-5.2	-5.4	8.3e-08	-0.64	0.20	0.80	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBA7	0.05	0.04	enet	7	0.05	1.6e-05	5.3	-5.5	3.0e-08	-0.53	0.04	0.96	FALSE
107	The Cancer Genome Atlas	Stomach Adenocarcinoma	RBM6	0.05	0.05	blup	79	0.06	3.7e-05	-4.8	-5.5	4.6e-08	-0.69	0.12	0.78	FALSE
108	The Cancer Genome Atlas	Stomach Adenocarcinoma	UBA7	0.04	0.05	lasso	1	0.04	1.0e-03	5.4	-5.4	8.0e-08	-0.50	0.03	0.87	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	MST1R	0.03	0.01	blup	32	0.03	3.1e-04	5.3	5.8	5.5e-09	0.67	0.04	0.83	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	RBM6	0.14	0.19	blup	79	0.20	1.4e-19	-5.2	-5.4	7.7e-08	-0.71	0.23	0.77	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	SLC38A3	0.03	0.02	blup	22	0.02	7.3e-03	5.9	-5.6	2.0e-08	-0.93	0.00	0.88	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	UBA7	0.03	0.01	blup	30	0.02	2.0e-03	5.3	-5.8	8.6e-09	-0.61	0.02	0.83	FALSE