Hub : Traits :

Average weekly beer plus cider intake

128 significantly associated models · 17 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	202651129	203152355	1	1	2.1e-08	1.0e-06	0.978	100	FZD7
2	3	49016056	50932324	12	1	2.4e-10	1.0e-09	0.043	89	MST1R
3	7	75059331	76363886	1	1	7.1e-09	9.2e-07	0.623	99	MDH2
4	8	8165004	9669775	1	1	8.2e-08	1.2e-07	0.043	85	ERI1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Miserableness	12.18	2	2	4.4	1	ERI1 MST1R
Qualifications: College or University degree	11.96	1	1	2.2	1	MST1R
Age at last live birth	9.52	1	1	2.2	1	MST1R
Qualifications: A levels/AS levels or equivalent	8.66	1	1	2.2	1	MST1R
Impedance of arm (left)	8.48	3	2	4.4	1	ERI1 FZD7 MST1R
Age at First Birth	8.35	1	1	2.2	1	MST1R
Impedance of whole body	8.22	3	2	4.4	1	ERI1 FZD7 MST1R
Impedance of arm (right)	8.09	3	1	2.2	1	ERI1 FZD7 MST1R
Age at first live birth	7.97	1	1	2.2	1	MST1R
Qualifications: None of the above	7.88	1	1	2.2	1	MST1R
Alcohol usually taken with meals	7.82	2	0	0.0	1	ERI1 MDH2
Body mass index (BMI)	7.80	2	1	2.2	1	ERI1 MST1R
Neuroticism score	7.65	2	1	2.2	1	ERI1 MST1R
Worrier / anxious feelings	7.28	1	1	2.2	1	ERI1
Intelligence (Savage-Jansen 2018)	7.16	1	1	2.2	1	MST1R
Seen doctor (GP) for nerves, anxiety, tension or depression	6.74	1	0	0.0	1	FZD7
Impedance of leg (left)	6.56	3	2	4.4	1	ERI1 MDH2 MST1R
Irritability	6.46	1	1	2.2	1	ERI1
Neuroticism (2016)	6.41	1	1	2.2	1	ERI1
Frequency of depressed mood in last 2 weeks	6.41	1	0	0.0	1	ERI1
Impedance of leg (right)	6.39	3	2	4.4	1	ERI1 MDH2 MST1R
Exposure to tobacco smoke at home	6.28	1	0	0.0	1	MST1R
Fed-up feelings	6.08	2	0	0.0	1	ERI1 MST1R
Mood swings	6.04	2	0	0.0	1	ERI1 MST1R
Depressed Affect (Nagel 2018)	6.03	1	1	2.2	1	MST1R
Frequency of unenthusiasm / disinterest in last 2 weeks	5.96	1	0	0.0	1	ERI1
BMI	5.80	1	1	2.2	1	MST1R
Frequency of tenseness / restlessness in last 2 weeks	5.76	2	0	0.0	1	ERI1 MST1R
Leg fat mass (left)	5.73	1	1	2.2	1	MST1R
Verbal and Numeric Reasoning (VNR)	5.70	1	1	2.2	1	MST1R
Leg fat mass (right)	5.64	1	1	2.2	1	MST1R
Arm fat mass (right)	5.62	2	1	2.2	1	ERI1 MST1R
Ever unenthusiastic/disinterested for a whole week	5.58	1	0	0.0	1	MST1R
Arm fat mass (left)	5.56	2	1	2.2	1	ERI1 MST1R
Ulcerative Colitis (UC)	5.39	1	1	2.2	1	MST1R
Taking other prescription medications	5.28	1	1	2.2	1	MST1R
Comparative body size at age 10	5.28	2	1	2.2	1	ERI1 MST1R
Overall health rating	5.25	1	1	2.2	1	MST1R
Tense / 'highly strung'	5.24	1	1	2.2	1	ERI1
Ever highly irritable/argumentative for 2 days	5.23	1	0	0.0	1	MST1R
Ulcerative Colitis	5.08	1	1	2.2	1	MST1R
Exposure to tobacco smoke outside home	5.01	1	0	0.0	1	MST1R
Ever depressed for a whole week	4.91	1	0	0.0	1	MST1R
Fluid intelligence score	4.90	1	1	2.2	1	MST1R
Chronic bronchitis/emphysema (mother)	4.89	1	0	0.0	1	MST1R
Guilty feelings	4.80	1	0	0.0	1	MST1R
Smoking Status	4.73	1	1	2.2	1	MST1R
Depression (Nagel 2018)	4.70	1	0	0.0	1	ERI1
Number of operations (self-reported)	4.67	1	1	2.2	1	MST1R
Alcohol intake versus 10 years previously	4.65	1	0	0.0	1	MST1R
Arm predicted mass (left)	4.64	2	1	2.2	1	FZD7 MST1R
Weight	4.62	2	1	2.2	1	ERI1 MST1R
Age when periods started (menarche)	4.55	1	1	2.2	1	MST1R
Arm fat-free mass (left)	4.54	2	1	2.2	1	FZD7 MST1R
Medication: Co-codamol	4.44	1	0	0.0	1	MST1R
Sensitivity / hurt feelings	4.37	1	1	2.2	1	ERI1
Arm predicted mass (right)	4.34	1	1	2.2	1	MST1R
Peak expiratory flow (PEF)	4.31	1	1	2.2	1	ERI1
Leg fat percentage (right)	4.26	1	1	2.2	1	MST1R
Whole body fat mass	4.25	1	1	2.2	1	MST1R
Leg fat percentage (left)	4.19	1	1	2.2	1	MST1R
Arm fat percentage (left)	4.17	2	1	2.2	1	ERI1 MST1R
Arm fat-free mass (right)	4.12	1	1	2.2	1	MST1R
Arm fat percentage (right)	4.09	1	1	2.2	1	MST1R
Leg pain on walking	4.07	1	0	0.0	1	MST1R
Heel bone mineral density (BMD) T-score, automated (left)	4.04	1	1	2.2	1	ERI1
Irritable Bowel Disease (IBD)	3.97	1	1	2.2	1	MST1R
Maternal smoking around birth	3.97	1	0	0.0	1	MST1R
Number of treatments/medications taken	3.85	1	0	0.0	1	MST1R
Basal metabolic rate	3.85	2	1	2.2	1	ERI1 MST1R
Number of full brothers	3.77	1	0	0.0	1	MST1R
Mouth/teeth dental problems: Dentures	3.67	1	0	0.0	1	MST1R
Qualifications: CSEs or equivalent	3.62	1	0	0.0	1	MST1R
Leg predicted mass (left)	3.62	2	1	2.2	1	ERI1 MST1R
Nervous feelings	3.61	1	0	0.0	1	ERI1
Leg fat-free mass (left)	3.60	2	1	2.2	1	ERI1 MST1R
Number of live births	3.57	1	0	0.0	1	MST1R
Whole body water mass	3.57	2	1	2.2	1	ERI1 MST1R
Suffer from 'nerves'	3.54	1	0	0.0	1	ERI1
Chronotype (morning person)	3.53	1	0	0.0	1	MST1R
Hip circumference	3.53	1	1	2.2	1	MST1R
Pain experienced in last month	3.50	1	0	0.0	1	MST1R
Whole body fat-free mass	3.42	2	1	2.2	1	ERI1 MST1R
Wheeze or whistling in the chest in last year	3.41	1	0	0.0	1	MST1R
Relative age of first facial hair	3.34	1	0	0.0	1	MST1R
Leg fat-free mass (right)	3.32	2	1	2.2	1	ERI1 MST1R
Respiratory disease	3.30	1	0	0.0	1	MST1R
Heel bone mineral density (BMD) T-score, automated (right)	3.30	1	0	0.0	1	ERI1
Leg predicted mass (right)	3.27	2	1	2.2	1	ERI1 MST1R
Knee pain experienced in last month	3.21	1	0	0.0	1	MST1R
Waist circumference	3.17	1	1	2.2	1	MST1R
Trunk fat-free mass	3.09	1	1	2.2	1	MST1R
Qualifications: nursing, teaching	3.07	1	0	0.0	1	MST1R
Medication: Paracetamol	3.01	1	0	0.0	1	MST1R
Trunk predicted mass	2.96	1	1	2.2	1	MST1R
Trunk fat mass	2.93	1	1	2.2	1	MST1R
Past tobacco smoking	2.91	1	0	0.0	1	MST1R
Diastolic blood pressure, automated reading	2.91	2	0	0.0	1	ERI1 MST1R
Medication: Paracetamol	2.73	1	0	0.0	1	MST1R
Forced expiratory volume in 1-second (FEV1), Best measure	2.66	1	0	0.0	1	ERI1
Body fat percentage	2.64	1	1	2.2	1	MST1R
High blood pressure	2.58	1	0	0.0	1	ERI1
Heel T-Score	2.52	1	1	2.2	1	FZD7
Neuroticism	2.49	1	0	0.0	1	MST1R
Prostate Cancer	2.45	1	0	0.0	1	MST1R
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.45	1	0	0.0	1	MST1R
Qualifications: O levels/GCSEs or equivalent	2.41	1	0	0.0	1	MST1R
Worry too long after embarrassment	2.41	1	0	0.0	1	ERI1
Hypothyroidism/myxoedema (self-reported)	2.37	1	0	0.0	1	ERI1
Crohns Disease (2012)	2.36	1	0	0.0	1	MST1R
Forced expiratory volume in 1-second (FEV1)	2.23	1	0	0.0	1	MST1R
Hypertension (Self-reported)	2.12	1	0	0.0	1	ERI1
Medication: Blood pressure	2.11	1	0	0.0	1	ERI1
Vascular/heart problems diagnosed by doctor	2.10	1	0	0.0	1	ERI1
Crohns Disease (2017)	1.90	1	0	0.0	1	MST1R
Trunk fat percentage	1.85	1	0	0.0	1	MST1R
Forced vital capacity (FVC), Best measure	1.70	1	0	0.0	1	MST1R
Forced vital capacity (FVC)	1.47	1	0	0.0	1	MST1R
Sitting height	1.41	1	1	2.2	1	ERI1
Blood White Count	1.25	1	1	2.2	1	MST1R
Blood Eosinophil Count	1.23	1	0	0.0	1	MST1R
Lung FVC	1.18	1	0	0.0	1	MST1R
Blood Platelet Count	0.78	1	1	2.2	1	MDH2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cerebellar Hemisphere	2	0.134	1.6
GTEx	Brain Frontal Cortex BA9	3	0.325	1.6
GTEx	Muscle Skeletal	2	0.069	1.6
GTEx	Pancreas	0	0.000	1.6
GTEx	Small Intestine Terminal Ileum	1	0.217	1.6
GTEx	Vagina	0	0.000	1.6
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.6
GTEx	Adipose Subcutaneous	2	0.057	1.5
GTEx	Adipose Visceral Omentum	2	0.098	1.5
GTEx	Adrenal Gland	1	0.069	1.5
GTEx	Artery Aorta	3	0.101	1.5
GTEx	Artery Tibial	3	0.080	1.5
GTEx	Brain Caudate basal ganglia	2	0.217	1.5
GTEx	Brain Cerebellum	4	0.202	1.5
GTEx	Brain Cortex	2	0.193	1.5
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.5
GTEx	Cells Transformed fibroblasts	2	0.048	1.5
GTEx	Esophagus Gastroesophageal Junction	1	0.069	1.5
GTEx	Esophagus Mucosa	3	0.090	1.5
GTEx	Esophagus Muscularis	3	0.093	1.5
GTEx	Heart Atrial Appendage	2	0.127	1.5
GTEx	Heart Left Ventricle	1	0.065	1.5
GTEx	Lung	3	0.104	1.5
GTEx	Nerve Tibial	2	0.046	1.5
GTEx	Prostate	1	0.120	1.5
GTEx	Skin Not Sun Exposed Suprapubic	3	0.122	1.5
GTEx	Skin Sun Exposed Lower leg	4	0.110	1.5
GTEx	Spleen	3	0.213	1.5
GTEx	Stomach	2	0.138	1.5
GTEx	Testis	4	0.127	1.5
GTEx	Thyroid	3	0.075	1.5
ROSMAP	Brain Pre-frontal Cortex	5	0.114	1.5
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	3	0.110	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	2	0.181	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	3	0.102	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.5
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.5
GTEx	Artery Coronary	1	0.085	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	1	0.160	1.4
GTEx	Breast Mammary Tissue	2	0.101	1.4
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.4
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.4
GTEx	Colon Sigmoid	2	0.137	1.4
GTEx	Colon Transverse	1	0.048	1.4
GTEx	Liver	1	0.139	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Pituitary	1	0.090	1.4
GTEx	Uterus	0	0.000	1.4
GTEx	Whole Blood	2	0.100	1.4
METSIM	Adipose	2	0.043	1.4
NTR	Blood	2	0.083	1.4
YFS	Blood	2	0.043	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	3	0.073	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	4	0.093	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	3	0.065	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	2	0.119	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	5	0.097	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.2