TWAS hub - ZNF286B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0626	0.0300	3.1e-03	0.060	NA	0.053	NA	0.056	1.6e-06	NA	6.5e-06	NA	3.3e-06
2	TCGA	Breast Invasive Carcinoma	0.0560	0.0318	3.1e-03	0.011	0.020	0.024	NA	0.012	2.0e-03	4.1e-05	7.8e-06	NA	1.2e-03
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0749	0.0394	3.4e-03	0.019	0.005	0.016	NA	-0.001	2.5e-03	8.9e-02	5.6e-03	NA	4.1e-01
4	TCGA	Lung Squamous Cell Carcinoma	0.0795	0.0387	1.1e-03	0.015	0.014	0.020	NA	0.014	6.9e-03	8.5e-03	2.2e-03	NA	9.2e-03
5	TCGA	Pheochromocytoma and Paraganglioma	0.3180	0.0950	2.4e-06	0.009	0.120	0.172	NA	0.098	1.3e-01	1.8e-05	2.3e-07	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Illnesses of father: Heart disease	5.2	7.2	11.4	-1.3	3.4	3.0	2.1	3.0
Medication for hormone replacement therapy	4.5	5.1	9.1	-1.7	1.6	1.3	3.0	3.0
Tinnitus: Yes, but not now, but have in the past	4.0	4.3	8.0	-0.0	-1.9	-2.7	-1.5	-2.8
Lupus	3.3	4.9	9.8	0.5	-2.0	-3.0	-1.4	-3.1
Alzheimer’s Disease (in father)	3.2	3.5	6.2	-2.2	2.5	2.1	0.9	1.2
Gout (self-reported)	3.2	4.4	7.0	-2.3	2.6	1.4	1.9	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.7	7.4	0.4	2.4	2.2	0.0	2.7
Medication for cholesterol	3.2	4.8	7.2	1.4	-1.8	-2.1	-2.7	-2.7
Stomach or abdominal pain in last month	3.0	3.7	8.6	-1.1	1.6	2.3	1.1	2.9
Irritability	2.9	4.9	9.9	0.2	2.3	2.7	1.4	3.1
Had menopause	2.7	3.3	5.2	1.5	-2.1	-1.9	-1.1	-2.3
Comparative height size at age 10	2.7	15.0	32.1	-0.0	-4.4	-5.7	-1.2	-4.7
Ever had bowel cancer screening	2.7	3.2	7.3	2.7	-1.8	-1.5	-1.6	-0.8
Number of live births	2.6	3.7	6.9	-0.8	-2.3	-2.6	-1.0	-2.2
HbA1C	2.5	2.8	7.1	1.8	-2.7	-1.3	-0.7	-1.1
Mouth/teeth dental problems: Dentures	2.5	4.2	13.4	-3.7	1.7	1.8	1.1	0.1
Wears glasses or contact lenses	2.5	2.9	4.6	2.1	-1.5	-1.6	-1.9	-1.3
Townsend deprivation index at recruitment	2.4	3.3	6.3	-1.6	2.5	1.7	1.9	1.0
Father’s age at death	2.3	3.1	7.1	1.0	-1.8	-1.7	-2.7	-1.2
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	8.7	2.9	-1.8	-1.2	-2.0	-0.8
Medication: Blood pressure	2.3	4.0	6.9	-1.2	1.5	2.6	2.5	1.7
Medication: Ramipril	2.2	2.9	8.3	-0.5	1.5	2.9	1.5	1.1
Medication: Lansoprazole	2.2	2.5	4.5	-1.1	2.1	1.6	0.9	1.8
Length of working week for main job	2.2	2.4	6.5	0.4	-2.6	-1.9	-1.2	-0.8
Alcohol drinker status: Never	2.2	2.6	5.8	-0.2	-1.2	-2.0	-1.4	-2.4
Medication: Atorvastatin	2.1	2.6	5.8	-0.7	1.2	2.4	1.5	1.7
Noisy workplace	2.0	2.5	3.8	1.1	-1.3	-2.0	-1.6	-1.7
Lung cancer (father)	2.0	2.3	6.0	0.2	-2.1	-0.9	-0.5	-2.5
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	6.9	1.2	-1.0	-2.3	-2.6	-1.4
High cholesterol (Self-reported)	2.0	3.6	7.1	-0.5	2.1	2.7	2.0	1.4
Age at first live birth	1.9	3.3	10.0	1.0	1.7	3.2	-0.1	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	3.9	2.0	-1.5	-1.0	-2.0	-0.2
Illnesses of father: None of the above (group 1)	1.8	2.2	3.6	0.9	-1.9	-1.2	-1.3	-1.9
Alzheimer’s Disease (including proxy)	1.7	2.5	3.8	-1.3	1.9	1.6	0.9	2.0
Sensitivity / hurt feelings	1.7	2.9	5.2	-1.2	1.8	2.0	0.8	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	2.9	-0.8	1.6	1.5	1.7	1.7
Unable to work because of sickness or disability	1.7	2.1	3.1	-1.8	0.9	1.7	1.6	1.2
Ovarian Cancer	1.6	2.1	4.5	0.9	-2.1	-2.1	-0.1	-0.8
High blood pressure (siblings)	1.6	2.3	5.5	-0.4	1.9	2.4	1.5	0.3
Migraine (self-reported)	1.6	2.0	4.0	-1.0	0.6	1.7	2.0	1.3
Chronic bronchitis/emphysema (father)	1.5	1.8	4.6	-0.7	-0.7	-1.2	-1.3	-2.1
Hair/balding pattern: Pattern 2	1.5	1.8	4.6	-1.0	0.6	1.4	1.1	2.1
Fluid intelligence score	1.5	3.2	7.9	-1.1	2.8	2.2	0.3	1.4
Medication: Ventolin 100micrograms inhaler	1.5	2.0	5.4	2.3	-0.9	0.2	-1.7	0.7
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.8	0.3	1.8	2.0	-0.1	1.3
Height	1.4	27.0	54.9	-0.5	-6.3	-6.0	-2.0	-7.4
Number of treatments/medications taken	1.4	2.5	5.9	-0.7	1.4	1.9	0.9	2.4
Asthma	1.4	2.7	8.1	0.1	0.6	1.8	1.3	2.9
Standing height	1.4	14.1	25.9	-0.4	-4.3	-4.8	-1.4	-5.1
Osteoporosis (self-reported)	1.4	1.7	3.4	-0.2	-1.1	-1.6	-1.1	-1.8
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.1	-0.6	1.9	2.0	0.4	0.9
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.1	1.0	-1.5	-1.8	-0.2	-1.7
Medication: Amlodipine	1.3	1.9	4.7	-2.2	0.3	1.0	0.8	1.7
Ever depressed for a whole week	1.3	1.6	5.2	-2.3	0.7	1.1	0.7	-0.7
Respiratory disease	1.2	2.6	6.0	0.4	0.9	2.1	1.3	2.4
Vitamin and mineral supplements	1.2	1.6	3.0	0.1	-1.3	-1.0	-1.4	-1.7
Medication: Levothyroxine sodium	1.2	2.1	3.5	-1.3	1.6	1.3	0.9	1.9
Time employed in main current job	1.2	1.4	2.7	-0.4	-1.6	-0.8	-1.3	-1.3
Overall health rating	1.2	2.6	4.6	-1.8	0.9	2.1	1.4	1.6
Had major operations	1.2	1.4	1.6	1.3	1.2	1.1	1.1	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	4.8	0.1	-1.6	-2.1	-0.6	-2.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.8	4.1	1.1	-1.4	-2.0	-0.8	-1.0
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.1	0.5	-1.5	-0.5	-1.1	-1.8
Cholesterol lowering medication	1.2	1.7	4.0	-0.2	1.6	2.0	1.2	0.7
Age at First Birth	1.1	1.6	4.3	1.6	-2.1	-1.0	0.1	0.5
Medication: Atenolol	1.1	1.4	4.8	-0.4	2.2	1.4	0.5	-0.1
Past tobacco smoking	1.1	2.1	4.1	-1.4	1.5	2.0	-0.4	1.5
Qualifications: None of the above	1.1	2.4	5.4	-2.3	-1.1	-1.3	-0.9	-1.7
Medication: Cholesterol lowering	1.1	1.8	4.9	-0.2	0.3	1.6	2.2	1.1
Trunk predicted mass	1.1	6.2	14.7	0.6	-3.1	-3.8	0.1	-2.5
Tense / ‘highly strung’	1.1	1.9	4.6	0.4	1.0	2.1	-0.3	1.9
Smoking status: Previous	1.1	1.6	3.1	1.2	-1.3	-1.7	0.2	-1.3
Asthma (self-reported)	1.1	2.1	6.9	0.5	0.3	1.6	0.9	2.6
Average weekly beer plus cider intake	1.1	1.6	4.7	-1.2	0.8	0.4	1.0	2.2
Heart disease (siblings)	1.1	1.4	3.5	0.1	-1.1	-0.2	-1.4	-1.9
Alcohol drinker status: Previous	1.1	1.2	3.5	-1.9	-0.8	-1.3	0.4	-0.2
Alzheimer’s Disease (in mother)	1.0	1.2	3.5	-0.6	0.8	0.9	0.8	1.9
Reaction Time	1.0	1.9	5.1	-0.6	2.3	1.6	1.0	0.8
Cardiovascular Disease	1.0	3.2	7.3	-0.2	1.4	2.7	2.2	1.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.3	0.6	-1.2	-1.1	-0.6	-1.5
Supplements: Glucosamine	1.0	1.2	2.6	1.1	0.4	1.4	0.5	1.6
Trunk fat-free mass	1.0	6.0	14.4	0.6	-3.1	-3.8	0.2	-2.4
Worrier / anxious feelings	1.0	1.8	3.9	-2.0	0.0	1.7	0.9	1.2
Pulse wave reflection index	1.0	1.3	1.8	0.0	1.2	1.2	1.3	1.3
Wheeze or whistling in the chest in last year	1.0	1.7	5.2	0.9	-0.3	1.6	0.3	2.3
Qualifications: College or University degree	1.0	3.1	6.6	2.5	0.6	1.4	-0.5	2.6
Medication: Allopurinol	1.0	1.3	2.2	-1.5	1.3	1.0	0.8	1.0
Suffer from ‘nerves’	1.0	1.5	3.1	-0.9	1.8	1.2	-0.1	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.9	-0.9	1.2	0.6	1.4	1.2
Breast cancer (self-reported)	1.0	1.2	1.9	0.0	-1.4	-1.4	-1.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	3.9	1.1	2.0	1.1	1.0	1.7
Financial situation satisfaction	1.0	1.2	3.7	-1.1	0.7	0.7	1.9	0.4
Medication: Bendroflumethiazide	1.0	1.5	3.5	-0.2	1.1	1.2	1.9	1.1
Waist Hip Ratio (WHR)	0.9	4.0	10.2	-0.2	-2.2	-1.9	1.1	-3.2
Average weekly spirits intake	0.9	1.1	1.8	-1.3	0.9	0.5	1.3	1.0
Diabetes (mother)	0.9	1.1	3.2	1.8	-0.9	-0.8	0.7	-0.6
Qualifications: CSEs or equivalent	0.9	1.1	3.7	0.3	0.4	-1.9	0.5	-1.2
Allergy	0.9	2.1	3.8	-0.7	-0.8	-1.7	-1.9	-1.6
Blood clot in the leg (DVT)	0.9	1.1	2.2	0.9	-0.9	-1.5	0.1	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.7	0.2	-1.3	-1.3	-0.6	-1.0
Whole body water mass	0.9	5.0	12.8	0.5	-2.8	-3.6	0.5	-2.0
Illnesses of father: High blood pressure	0.9	1.1	3.0	1.0	0.6	0.2	1.1	1.7
Fractured/broken bones in last 5 years	0.9	1.2	3.4	-0.0	-1.8	-1.3	-0.7	-0.5
Blood Platelet Count	0.8	8.7	14.6	2.7	3.0	3.3	1.1	3.8
Hearing difficulty/problems: Yes	0.8	1.2	3.3	-0.8	-1.2	-0.6	-0.3	-1.8
Ever had hysterectomy (womb removed)	0.8	0.9	1.9	0.2	-1.1	-1.0	0.6	-1.4
Current tobacco smoking	0.8	1.3	3.4	-1.8	0.9	1.0	0.9	0.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.2	-1.5	0.7	0.3	1.5	0.3
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.9	2.0	-0.8	-1.1	-1.0	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.7	-1.1	0.3	-0.6	1.6	0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.9	-1.4	1.4	0.6	0.8	0.8
Heart disease (mother)	0.8	1.0	2.1	-0.1	1.3	1.4	0.4	1.0
Chest pain or discomfort	0.8	1.2	3.9	1.3	0.5	0.6	0.1	2.0
Age at last live birth	0.8	1.1	4.1	-0.1	0.9	2.0	-0.3	0.8
Whole body fat-free mass	0.8	4.8	12.0	0.4	-2.8	-3.5	0.6	-1.9
Ever taken oral contraceptive pill	0.8	0.8	2.4	0.2	0.8	1.5	-0.9	0.7
Commuting to job workplace: Public transport	0.8	0.9	1.3	0.3	-1.0	-1.1	0.9	-1.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.3	1.8	-0.4	-0.6	-0.7	-0.9
Basal metabolic rate	0.8	4.2	10.6	0.1	-2.6	-3.3	0.6	-1.8
Arm fat-free mass (left)	0.8	4.1	10.6	0.5	-2.5	-3.3	0.4	-1.8
Age started oral contraceptive pill	0.8	1.0	2.2	0.8	-1.5	-0.6	0.2	-1.3
Basal cell carcinoma (self-reported)	0.8	0.9	1.7	-0.8	1.1	0.9	0.4	1.3
Crohns Disease (2017)	0.7	1.5	4.7	0.2	-0.7	-1.1	-2.2	-0.9
Ulcerative Colitis (UC)	0.7	1.2	3.3	0.1	1.8	1.2	-1.1	0.4
Medication: Co-codamol	0.7	0.9	1.8	-1.3	0.4	0.2	1.2	1.0
Relative age voice broke	0.7	1.1	3.4	0.1	-0.7	-1.9	0.3	-1.2
Pain all over the body in last month	0.7	0.7	2.9	-0.6	0.5	-0.3	1.7	0.0
Alcohol intake versus 10 years previously	0.7	1.0	2.1	1.1	-1.1	-0.5	-0.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.1	-0.6	0.9	1.5	0.6	1.4
Hair/balding pattern: Pattern 3	0.7	1.1	2.1	1.5	0.8	0.5	1.4	0.8
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.7	-0.9	1.2	1.1	0.7	1.7
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.9	1.3	-1.4	-0.4	0.0	0.3
Arm fat-free mass (right)	0.7	3.6	8.9	0.3	-2.5	-3.0	0.4	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	-1.2	-0.4	0.9	1.3	0.4
Arm predicted mass (right)	0.7	3.7	9.6	0.3	-2.5	-3.1	0.2	-1.7
Medication: Aspirin	0.7	0.9	1.5	0.9	0.7	0.9	1.2	0.9
Mother’s age at death	0.7	0.9	2.2	0.9	-1.0	-1.5	0.5	-0.3
Arm predicted mass (left)	0.7	3.8	10.0	0.5	-2.4	-3.2	0.6	-1.6
Breast Cancer	0.6	1.5	4.3	-0.4	-0.9	-2.1	-0.8	-1.3
Neuroticism	0.6	1.4	2.2	0.0	1.3	1.5	1.1	1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.6	0.3	-1.6	0.4	-0.7	-0.6
Systolic blood pressure, automated reading	0.6	1.6	4.2	2.1	-1.3	-0.9	-0.9	-0.8
Supplements: Zinc	0.6	0.6	1.4	0.1	0.5	0.9	0.7	1.2
High blood pressure	0.6	1.7	3.8	-0.5	0.8	2.0	1.9	0.6
Multivitamins +/- minerals	0.6	0.8	1.8	0.6	0.5	0.7	0.9	1.3
Leg predicted mass (left)	0.6	3.0	7.8	-0.1	-2.2	-2.8	1.0	-1.1
Neuroticism score	0.6	1.4	2.5	-0.6	1.2	1.5	0.3	1.6
Prospective memory result	0.6	0.8	1.8	-1.3	-1.0	-0.6	-0.2	-0.8
Exposure to tobacco smoke at home	0.6	0.7	2.5	-0.3	-0.2	-1.0	-1.6	-0.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.7	0.8	-1.3	-0.3	-1.1	0.1
Headache pain in last month	0.6	0.9	3.4	1.1	-0.2	0.4	-0.0	1.8
Birth weight	0.6	1.2	3.6	0.2	-0.4	-1.4	0.3	-1.9
Eye problems/disorders: None of the above	0.6	0.7	1.4	-1.0	0.8	0.3	0.8	1.2
Angina (self-reported)	0.6	0.8	2.5	1.0	0.2	1.6	0.6	0.1
Alcohol intake frequency.	0.6	1.5	5.5	-2.4	-0.0	-0.5	0.3	-1.2
Leg pain on walking	0.6	0.7	1.6	0.2	-1.3	-1.0	0.9	-0.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.6	-1.3	0.4	1.1	-0.4	0.8
Medication: Aspirin	0.6	0.8	1.5	0.7	0.8	0.9	1.2	0.8
Hypertension (Self-reported)	0.6	1.5	3.5	-0.3	0.6	1.9	1.9	0.6
Friendships satisfaction	0.6	0.7	3.1	1.8	0.1	-0.2	-0.6	0.3
Commuting to job workplace: Walk	0.6	0.6	2.8	-0.1	0.0	-1.7	-0.3	-0.4
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.0	0.2	-0.5	-1.8	-2.0	-0.4
Irritable Bowel Disease (IBD)	0.5	1.1	3.9	0.5	1.1	0.3	-2.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.8	-0.5	2.0	0.5	0.4	1.2
HDL Cholesterol	0.5	0.9	2.4	-0.8	0.0	1.1	0.4	1.5
Angina	0.5	0.7	2.1	0.9	0.1	1.5	0.6	-0.0
Diabetes (father)	0.5	0.6	1.1	-0.4	0.8	-0.1	1.1	1.0
Leg fat-free mass (left)	0.5	2.9	7.2	-0.1	-2.2	-2.7	1.0	-1.2
Fed-up feelings	0.5	1.0	2.4	-1.0	1.1	1.5	0.3	0.1
Waist circumference	0.5	1.8	2.7	-0.3	-1.6	-1.6	1.1	-1.5
Nervous feelings	0.5	1.0	2.3	-0.6	0.7	1.0	-1.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.1	-0.1	0.6	1.4	0.9	0.7
Mouth/teeth dental problems	0.5	0.8	3.0	1.7	-0.9	-0.0	0.1	-0.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.2	1.5	-0.7	-0.1	0.6	-0.4
Falls in the last year	0.5	0.6	1.7	0.8	-0.8	-1.3	0.1	0.4
Depression (self-reported)	0.5	0.6	1.0	-0.9	-0.1	1.0	-0.9	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.3	-0.8	0.4	1.5	-0.2	0.9
Hair/balding pattern: Pattern 4	0.5	1.3	4.1	-0.7	1.1	0.6	-2.0	0.6
Glaucoma (self-reported)	0.5	0.5	2.3	1.5	-0.4	-0.4	0.3	-0.2
Exposure to tobacco smoke outside home	0.5	0.7	2.2	-1.5	0.7	0.2	-0.0	0.8
Number of full sisters	0.5	0.6	1.2	-1.1	-0.7	0.0	0.8	-0.7
Family relationship satisfaction	0.5	0.6	2.5	1.6	-0.1	-0.1	0.5	0.4
Leg fat-free mass (right)	0.5	2.5	7.0	0.1	-2.0	-2.6	0.8	-1.1
Qualifications: nursing, teaching	0.5	0.8	3.0	-0.2	0.1	0.9	1.7	0.2
Eye problems/disorders: Cataract	0.5	0.6	1.7	0.0	-0.6	-0.7	-0.5	-1.3
Back pain experienced in last month	0.5	0.7	1.4	1.0	0.5	0.7	-0.6	1.2
Smoking status: Current	0.5	0.8	2.4	-1.5	0.7	0.6	0.7	0.5
Leg predicted mass (right)	0.5	2.6	7.3	0.1	-2.0	-2.7	0.7	-1.1
Number of self-reported non-cancer illnesses	0.5	0.9	2.4	0.1	0.2	1.4	1.5	0.2
Eye problems/disorders: Glaucoma	0.5	0.6	2.3	1.5	-0.2	-0.2	-0.8	-0.5
Risk taking	0.5	0.7	2.0	-0.7	-0.8	0.1	-0.6	-1.4
Body Mass Index (BMI) (2010)	0.4	0.6	1.1	-0.8	0.0	0.8	0.7	1.0
Smoking Status	0.4	0.9	2.0	0.2	-1.3	-1.4	-0.0	-1.0
Hypothyroidism (self reported)	0.4	0.8	1.3	-0.6	1.1	0.9	0.9	1.0
Relative age of first facial hair	0.4	0.8	2.3	0.3	-0.9	-0.8	0.3	-1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	-0.3	-0.0	1.0	0.8	0.6
Hand grip strength (right)	0.4	1.0	3.0	1.7	-0.3	-0.4	-0.7	1.0
Taking other prescription medications	0.4	0.7	2.9	0.1	0.3	0.3	0.5	1.7
Serious illness, injury or assault to yourself	0.4	0.5	1.2	-1.1	-0.9	0.2	-0.1	0.4
Sitting height	0.4	2.6	4.5	1.5	-2.1	-1.9	-0.7	-1.4
High blood pressure (mother)	0.4	0.6	1.4	-0.4	-0.9	-0.8	0.2	-1.2
Medication: Simvastatin	0.4	0.6	1.9	-0.0	0.8	1.4	0.4	-0.2
Illnesses of siblings	0.4	0.5	1.4	0.5	-0.1	-1.2	-0.3	0.9
Weight	0.4	1.9	3.7	-0.6	-1.8	-1.9	0.6	-1.4
Pulse rate	0.4	0.7	2.3	0.8	-0.5	-0.2	-0.6	-1.5
Happiness	0.4	0.5	1.6	1.3	-0.3	-0.3	0.4	-0.7
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	0.6	-0.5	-0.4	-0.4	-1.1
Birth weight of first child	0.4	0.7	1.3	0.5	0.9	1.1	-0.3	1.1
Number of children fathered	0.4	0.4	1.7	0.1	0.1	1.3	-0.2	0.6
Neck or shoulder pain in last month	0.4	0.5	2.3	1.5	-0.2	0.1	-0.3	0.4
Medication: Ibuprofen	0.4	0.4	0.8	0.8	-0.7	-0.0	-0.9	-0.4
Medication: Seretide 50 evohaler	0.4	0.5	0.9	0.9	-0.9	-0.2	-0.8	0.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.7	-0.2	-0.6	-1.3	0.4	0.3
Mood swings	0.4	0.7	1.5	-0.9	0.8	1.2	0.3	0.8
Diabetes diagnosed by doctor	0.4	0.7	2.2	1.5	-0.9	-0.6	0.1	-0.4
Medication: Gliclazide	0.4	0.4	0.8	0.4	-0.9	0.8	0.7	0.1
Guilty feelings	0.4	0.6	1.9	1.4	-0.1	-0.5	-0.9	-0.0
Hearing aid user	0.4	0.5	1.2	0.7	-0.1	1.1	-0.5	0.5
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.9	0.2	-0.3	-0.5	-0.9	0.9
Ever smoked	0.4	0.7	1.0	0.9	-0.9	-1.0	0.2	-0.8
Commuting to job workplace: Cycle	0.4	0.5	1.1	1.0	0.4	0.9	0.3	0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.5	-0.1	-0.5	-0.3	-0.6	1.2
Worry (Nagel 2018)	0.3	0.5	2.7	-1.6	0.0	0.0	0.0	0.0
Fasting Glucose	0.3	0.4	0.8	-0.5	0.9	0.1	-0.9	0.5
Blood Red Count	0.3	2.8	10.5	-0.1	-1.6	-0.9	-0.3	-3.2
Chronotype (morning person)	0.3	0.6	1.4	0.3	-0.6	-1.2	-1.1	-0.5
Hand grip strength (left)	0.3	0.8	3.3	1.8	-0.5	-0.3	-0.1	0.7
Pack years adult smoking proportion	0.3	0.5	1.1	-0.5	1.1	0.7	0.3	0.6
Age when periods started (menarche)	0.3	0.7	1.0	0.1	-0.9	-0.8	-0.9	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	-0.5	0.4	-0.0	1.0	1.2
Hearing difficulty/problems with background noise	0.3	0.5	1.1	0.2	-0.8	-0.0	-1.1	-1.0
Had other major operations	0.3	0.3	0.7	-0.3	-0.8	-0.3	-0.5	0.7
Financial difficulties in last 2 years	0.3	0.5	1.2	0.2	-1.1	-0.2	0.3	-1.0
Diabetes (self-reported)	0.3	0.5	2.0	1.4	-0.3	0.0	0.1	0.6
Impedance of arm (left)	0.3	1.5	4.5	-2.1	1.1	1.1	-0.4	-0.8
Emphysema/chronic bronchitis	0.3	0.4	1.1	0.0	-0.2	1.1	0.6	-0.6
Medication: Omeprazole	0.3	0.4	0.8	0.1	-0.9	-0.5	-0.8	0.4
Mean time to correctly identify matches	0.3	0.6	1.5	0.3	1.2	1.1	0.4	0.4
Knee pain experienced in last month	0.3	0.4	1.2	0.6	-0.4	1.1	-0.6	-0.2
Illnesses of siblings: Diabetes	0.3	0.4	1.1	1.0	-0.7	-0.3	0.2	0.3
Mineral and other dietary supplements	0.3	0.4	1.6	-0.3	-1.2	-0.6	0.4	0.0
Impedance of whole body	0.3	1.7	4.1	-2.0	1.2	1.4	-0.7	-0.6
Triglycerides	0.2	0.3	0.7	0.8	0.0	-0.4	0.8	0.3
Ulcerative Colitis	0.2	0.3	1.5	-1.2	0.0	0.0	0.0	0.0
Blood White Count	0.2	1.2	3.2	1.5	0.5	0.3	1.8	0.1
Systolic Blood Pressure	0.2	0.8	1.5	0.6	1.1	1.2	0.4	0.8
Allergy or Eczema	0.2	0.4	1.5	0.1	0.4	1.2	-0.1	-0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	1.2	-0.5	-0.1	0.4	0.0
Lung FEV1/FVC ratio	0.2	1.2	4.8	-0.0	-0.8	-0.6	-0.1	-2.2
Lung FVC	0.2	0.9	2.4	0.7	0.9	0.4	-0.7	1.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	0.1	-0.3	-0.7	-0.0	-1.0
Severe depression (siblings)	0.2	0.2	0.5	0.7	-0.4	0.2	0.0	-0.5
Impedance of leg (right)	0.2	0.8	1.6	-1.3	0.2	0.7	-0.8	-1.1
Trunk fat percentage	0.2	0.9	3.8	-2.0	0.4	0.3	0.6	-0.3
Average weekly fortified wine intake	0.2	0.3	1.0	0.3	-0.2	0.5	1.0	-0.1
Maternal smoking around birth	0.2	0.2	0.5	-0.2	-0.7	-0.4	-0.4	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	0.1	0.3	1.0	1.0	0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.5	-0.7	0.5	0.3	0.2
Impedance of leg (left)	0.2	1.2	1.8	-1.3	1.0	1.2	-0.9	-0.9
Trunk fat mass	0.2	0.8	2.4	-1.5	-0.5	-0.6	0.7	-0.8
Alcohol usually taken with meals	0.2	0.3	0.8	-0.2	0.7	0.9	0.4	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.1	-0.3	-0.2	-0.5	0.2	1.5
Heart attack	0.2	0.3	0.7	-0.0	-0.8	0.3	-0.2	-0.7
Impedance of arm (right)	0.2	0.7	1.9	-1.4	0.5	0.3	-0.3	-1.2
Illnesses of mother	0.2	0.2	0.6	0.5	0.8	0.2	-0.5	-0.1
Breastfed as a baby	0.2	0.2	0.5	0.7	-0.2	-0.5	0.6	0.4
Peak expiratory flow (PEF)	0.2	0.5	1.3	1.1	-0.4	-1.1	-0.1	0.2
Body fat percentage	0.2	0.9	2.8	-1.7	0.7	0.6	0.8	0.2
Leg fat percentage (right)	0.2	0.6	1.4	-1.2	0.4	0.6	1.0	0.4
Comparative body size at age 10	0.2	0.6	1.2	-1.1	-0.9	-0.7	0.6	-0.4
Worry too long after embarrassment	0.2	0.3	0.5	0.7	-0.6	-0.3	-0.6	0.6
Pulse wave peak to peak time	0.2	0.3	0.8	-0.6	0.2	0.2	0.5	0.9
Health satisfaction	0.2	0.3	0.5	0.6	-0.7	-0.4	0.6	0.3
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	-0.4	0.5	1.0	0.3	0.3
Whole body fat mass	0.2	0.7	2.1	-1.4	-0.3	-0.5	0.9	-0.6
Pulse rate, automated reading	0.2	0.7	1.5	1.2	0.7	1.1	0.3	-0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.8	0.3	0.3	0.9	-0.4	-0.3
Arm fat percentage (left)	0.2	0.8	2.2	-1.5	0.6	0.5	1.0	0.3
Loneliness, isolation	0.2	0.3	0.7	0.6	0.3	0.8	0.4	0.2
Long-standing illness, disability or infirmity	0.2	0.4	0.7	0.2	-0.8	-0.0	0.6	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.3	0.5	-0.7	-0.2	0.4
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.5	0.8	0.5	0.5	-0.2
Arm fat mass (left)	0.2	0.7	1.7	-1.3	-0.2	-0.6	1.1	-0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.4	-0.1	-0.7	-0.5	-0.4	-0.6
Medication: Blood pressure	0.2	0.5	1.4	0.0	0.1	1.2	0.9	0.4
Medication: Paracetamol	0.2	0.3	0.5	-0.4	-0.6	-0.5	-0.1	-0.7
Medication: Lisinopril	0.2	0.2	0.9	-0.1	-0.1	-0.1	0.9	-0.4
Leg fat percentage (left)	0.2	0.8	1.4	-1.2	0.8	0.9	0.9	0.6
Number of operations (self-reported)	0.2	0.3	0.7	0.8	-0.5	-0.5	-0.6	-0.0
Diastolic blood pressure, automated reading	0.2	0.6	1.4	1.2	-0.6	0.6	-0.8	-0.5
Myopia	0.2	0.3	1.0	0.2	-1.0	-0.6	-0.1	-0.5
Pain experienced in last month	0.2	0.4	0.9	-0.9	0.0	-0.3	0.9	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	-0.3	-0.7	0.5	0.1	-0.7
Schizophrenia (2018)	0.1	0.2	0.7	-0.9	0.0	0.0	-0.6	0.0
Prostate Cancer	0.1	0.2	0.3	0.6	0.6	0.5	-0.2	-0.3
Coronary Artery Disease (CAD)	0.1	0.1	0.4	-0.7	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.1	0.1	0.5	-0.7	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.1	0.2	0.5	-0.2	-0.0	0.6	0.7	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.6	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.1	0.8	1.4	0.7	0.7	1.2	0.9	0.8
Heel T-Score	0.1	0.8	3.0	-0.2	0.6	0.1	0.9	1.7
BMI	0.1	0.7	1.8	0.0	0.3	0.4	1.2	1.3
Hair Pigment	0.1	4.1	8.0	1.5	1.4	2.8	1.9	2.1
Tanning	0.1	0.8	1.9	0.3	-0.9	-0.6	-1.4	-0.8
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	0.4	0.1	0.3	0.3	0.6
Medication: Metformin	0.1	0.1	0.3	0.5	-0.2	-0.4	0.3	0.1
Body mass index (BMI)	0.1	0.5	1.6	-0.4	0.1	0.1	1.2	0.8
Number of incorrect matches in round	0.1	0.2	0.3	0.3	-0.6	0.2	-0.6	-0.3
Forced vital capacity (FVC)	0.1	0.4	1.3	0.8	0.1	-1.1	-0.2	0.3
Arm fat percentage (right)	0.1	0.4	0.9	-1.0	0.4	0.1	1.0	0.2
Hip circumference	0.1	0.5	1.4	-0.2	-0.9	-1.2	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.4	0.5	0.4	-0.6	-0.1	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	0.2	0.5	0.2	0.3	0.6
Arm fat mass (right)	0.1	0.6	1.2	-1.1	-0.3	-0.7	1.0	-0.2
Loud music exposure frequency	0.1	0.1	0.2	-0.4	0.1	-0.4	0.2	-0.4
Medication: Paracetamol	0.1	0.1	0.3	-0.3	-0.3	-0.5	0.0	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	1.4	0.8	-0.3	-1.2	0.2	-0.5
Number of full brothers	0.1	0.2	0.4	0.5	0.1	0.5	0.0	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.2	0.3	0.3	-0.3	-0.2
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.1	0.2	0.4	-0.4	-0.0
Leg fat mass (right)	0.1	0.4	1.0	-0.9	-0.4	-0.4	1.0	-0.1
Supplements: Vitamin C	0.1	0.2	0.5	-0.0	0.6	0.3	0.0	0.7
Average weekly red wine intake	0.1	0.1	0.4	0.2	0.0	0.1	-0.4	-0.6
Miserableness	0.1	0.2	0.5	-0.7	0.1	0.6	0.2	0.6
Supplements: Calcium	0.1	0.1	0.3	-0.2	-0.3	-0.5	-0.4	0.0
Pack years of smoking	0.1	0.1	0.4	-0.3	0.6	0.1	0.2	-0.1
Leg fat mass (left)	0.1	0.4	1.0	-0.9	-0.1	-0.3	1.0	0.0
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.5	0.0	0.0	0.0	0.0
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	-0.1	0.0	0.0	0.0	0.0
Depression (Nagel 2018)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.4	0.7	0.0	0.0	0.0	0.0
Neuroticism (Nagel 2018)	0.0	0.1	0.4	-0.6	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.2	0.0	-0.0	0.1	0.2
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	0.4	0.3	-0.5	0.4	-0.3

Hub : Genes

ZNF286B

Models

Trait associations