Best TWAS P=2.2e-38 · Best GWAS P=9.1e-50 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C6orf106 | 0.29 | 0.21 | bslmm | 382 | 0.23 | 6.9e-28 | 10.67 | 9.7 | 4.6e-22 | -0.07 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | FANCE | 0.03 | 0.02 | bslmm | 420 | 0.01 | 1.7e-02 | -7.60 | -10.6 | 3.1e-26 | 0.08 | 0.27 | 0.30 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | PACSIN1 | 0.07 | 0.01 | lasso | 6 | 0.02 | 1.1e-03 | 11.06 | 9.3 | 1.5e-20 | 0.16 | 0.33 | 0.03 | FALSE |
4 | CommonMind | Brain Pre-frontal Cortex | RPL10A | 0.21 | 0.09 | enet | 30 | 0.11 | 2.6e-13 | -6.44 | -5.4 | 6.0e-08 | -0.01 | 1.00 | 0.00 | TRUE |
5 | GTEx | Adipose Subcutaneous | RPL10A | 0.06 | 0.02 | enet | 27 | 0.03 | 2.6e-03 | -6.62 | -6.1 | 9.1e-10 | -0.10 | 0.32 | 0.04 | FALSE |
6 | GTEx | Artery Aorta | RPL10A | 0.20 | 0.12 | lasso | 5 | 0.11 | 8.8e-07 | -6.43 | -6.8 | 1.3e-11 | -0.04 | 0.96 | 0.00 | FALSE |
7 | GTEx | Artery Tibial | C6orf106 | 0.07 | 0.02 | lasso | 4 | 0.02 | 8.8e-03 | -6.21 | 8.3 | 7.5e-17 | -0.13 | 0.10 | 0.05 | FALSE |
8 | GTEx | Artery Tibial | RPL10A | 0.11 | 0.08 | lasso | 2 | 0.09 | 1.5e-07 | -6.12 | -6.5 | 9.1e-11 | -0.08 | 1.00 | 0.00 | FALSE |
9 | GTEx | Brain Cerebellum | PPARD | 0.37 | 0.06 | lasso | 18 | 0.13 | 9.3e-05 | 1.34 | -6.2 | 4.4e-10 | 0.05 | 0.14 | 0.05 | FALSE |
10 | GTEx | Brain Cortex | C6orf106 | 0.22 | 0.07 | enet | 16 | 0.10 | 1.1e-03 | 11.04 | 10.7 | 7.0e-27 | 0.26 | 0.51 | 0.03 | FALSE |
11 | GTEx | Brain Frontal Cortex BA9 | TAF11 | 0.25 | 0.01 | lasso | 10 | 0.00 | 2.7e-01 | -5.13 | -5.3 | 1.3e-07 | 0.00 | 0.07 | 0.06 | FALSE |
12 | GTEx | Brain Frontal Cortex BA9 | RPS10 | 0.21 | 0.08 | lasso | 3 | 0.06 | 8.6e-03 | 3.64 | 5.3 | 9.3e-08 | -0.05 | 0.12 | 0.05 | FALSE |
13 | GTEx | Cells EBV-transformed lymphocytes | C6orf106 | 0.20 | 0.00 | lasso | 5 | 0.00 | 2.7e-01 | 7.43 | 5.9 | 2.8e-09 | 0.08 | 0.07 | 0.05 | FALSE |
14 | GTEx | Cells Transformed fibroblasts | TEAD3 | 0.36 | 0.29 | enet | 27 | 0.32 | 8.4e-25 | 3.35 | -5.8 | 8.1e-09 | -0.09 | 1.00 | 0.00 | FALSE |
15 | GTEx | Cells Transformed fibroblasts | NUDT3 | 0.11 | 0.03 | lasso | 3 | 0.02 | 9.2e-03 | 6.36 | -5.8 | 5.0e-09 | -0.40 | 0.24 | 0.03 | TRUE |
16 | GTEx | Colon Transverse | C6orf106 | 0.15 | 0.05 | lasso | 1 | 0.03 | 1.5e-02 | 8.07 | 8.1 | 7.3e-16 | -0.03 | 0.17 | 0.04 | FALSE |
17 | GTEx | Colon Transverse | RPL10A | 0.12 | 0.05 | lasso | 4 | 0.05 | 2.5e-03 | -6.12 | -6.9 | 4.8e-12 | -0.06 | 0.26 | 0.12 | FALSE |
18 | GTEx | Esophagus Mucosa | RPL10A | 0.14 | 0.10 | enet | 17 | 0.09 | 2.1e-06 | -6.12 | -8.8 | 1.9e-18 | -0.12 | 0.93 | 0.02 | TRUE |
19 | GTEx | Esophagus Muscularis | RPL10A | 0.31 | 0.19 | lasso | 5 | 0.18 | 4.6e-11 | -6.43 | -6.3 | 2.6e-10 | -0.01 | 1.00 | 0.00 | FALSE |
20 | GTEx | Heart Atrial Appendage | TEAD3 | 0.17 | 0.08 | lasso | 6 | 0.09 | 1.1e-04 | 4.54 | -5.2 | 2.4e-07 | 0.01 | 0.56 | 0.03 | FALSE |
21 | GTEx | Muscle Skeletal | C6orf106 | 0.08 | 0.06 | lasso | 4 | 0.06 | 7.1e-07 | 4.81 | -5.5 | 5.0e-08 | -0.10 | 0.98 | 0.00 | FALSE |
22 | GTEx | Nerve Tibial | DEF6 | 0.15 | 0.00 | lasso | 8 | 0.00 | 1.6e-01 | -6.41 | 8.0 | 1.2e-15 | -0.01 | 0.18 | 0.05 | FALSE |
23 | GTEx | Nerve Tibial | C6orf106 | 0.11 | 0.07 | enet | 17 | 0.07 | 1.3e-05 | 11.21 | 11.8 | 4.9e-32 | 0.03 | 0.71 | 0.01 | FALSE |
24 | GTEx | Nerve Tibial | RPL10A | 0.14 | 0.12 | lasso | 3 | 0.12 | 9.7e-09 | -6.43 | -5.8 | 7.5e-09 | -0.01 | 1.00 | 0.00 | FALSE |
25 | GTEx | Pancreas | C6orf106 | 0.14 | 0.11 | enet | 11 | 0.13 | 2.8e-06 | 4.76 | 9.2 | 4.9e-20 | 0.10 | 0.86 | 0.01 | FALSE |
26 | GTEx | Skin Not Sun Exposed Suprapubic | TEAD3 | 0.15 | 0.06 | lasso | 5 | 0.08 | 2.5e-05 | -6.16 | -7.5 | 7.4e-14 | -0.09 | 0.39 | 0.51 | FALSE |
27 | GTEx | Skin Not Sun Exposed Suprapubic | SNRPC | 0.18 | 0.04 | enet | 37 | 0.03 | 1.0e-02 | 0.64 | 5.8 | 7.2e-09 | -0.04 | 0.25 | 0.03 | FALSE |
28 | GTEx | Skin Sun Exposed Lower leg | C6orf106 | 0.09 | 0.04 | enet | 25 | 0.02 | 4.6e-03 | -5.59 | 9.6 | 6.8e-22 | 0.04 | 0.38 | 0.02 | FALSE |
29 | GTEx | Testis | ZNF76 | 0.15 | 0.14 | enet | 8 | 0.12 | 4.4e-06 | -6.43 | 6.9 | 5.0e-12 | -0.02 | 0.94 | 0.01 | FALSE |
30 | GTEx | Thyroid | C6orf106 | 0.09 | 0.01 | enet | 29 | 0.01 | 1.1e-01 | 11.06 | 7.3 | 3.0e-13 | -0.10 | 0.10 | 0.03 | TRUE |
31 | GTEx | Thyroid | RPL10A | 0.16 | 0.09 | lasso | 11 | 0.07 | 8.9e-06 | -6.08 | -6.1 | 8.2e-10 | -0.13 | 0.89 | 0.01 | FALSE |
32 | GTEx | Whole Blood | DEF6 | 0.14 | 0.05 | lasso | 4 | 0.03 | 9.9e-04 | -6.54 | 6.4 | 1.5e-10 | -0.14 | 0.87 | 0.00 | FALSE |
33 | METSIM | Adipose | C6orf106 | 0.04 | 0.02 | blup | 381 | 0.02 | 7.7e-04 | 5.29 | 5.2 | 1.8e-07 | -0.13 | 0.43 | 0.02 | FALSE |
34 | METSIM | Adipose | RPL10A | 0.18 | 0.13 | lasso | 15 | 0.13 | 3.4e-19 | -6.43 | -5.8 | 5.1e-09 | 0.00 | 1.00 | 0.00 | FALSE |
35 | NTR | Blood | C6orf106 | 0.03 | 0.02 | lasso | 6 | 0.02 | 7.2e-07 | 11.00 | 11.8 | 4.3e-32 | 0.05 | 1.00 | 0.00 | FALSE |
36 | NTR | Blood | ZNF76 | 0.01 | 0.00 | blup | 424 | 0.00 | 3.8e-02 | -4.77 | 7.9 | 2.5e-15 | -0.17 | 0.24 | 0.02 | FALSE |
37 | ROSMAP | Brain Pre-frontal Cortex | DEF6 | 0.04 | 0.02 | bslmm | 421 | 0.02 | 1.8e-03 | -7.70 | 6.5 | 6.9e-11 | -0.18 | 0.78 | 0.04 | FALSE |
38 | ROSMAP | Brain Pre-frontal Cortex | ZNF76 | 0.04 | 0.00 | blup | 424 | 0.02 | 2.1e-03 | -6.40 | 5.7 | 1.4e-08 | -0.22 | 0.53 | 0.02 | FALSE |
39 | ROSMAP | Brain Pre-frontal Cortex | PACSIN1 | 0.09 | 0.00 | blup | 359 | 0.02 | 4.5e-04 | 10.67 | 10.5 | 5.4e-26 | 0.27 | 0.18 | 0.07 | FALSE |
40 | ROSMAP | Brain Pre-frontal Cortex | C6orf106 | 0.30 | 0.26 | bslmm | 372 | 0.33 | 9.3e-44 | 11.00 | 12.3 | 1.6e-34 | 0.00 | 1.00 | 0.00 | FALSE |
41 | YFS | Blood | ZNF76 | 0.05 | 0.08 | lasso | 4 | 0.07 | 6.7e-23 | -6.52 | 6.4 | 1.9e-10 | -0.17 | 1.00 | 0.00 | FALSE |
42 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RPL10A | 0.03 | 0.00 | blup | 54 | 0.02 | 6.0e-03 | -7.79 | -8.1 | 8.2e-16 | 0.03 | 0.01 | 0.85 | FALSE |
43 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TCP11 | 0.03 | 0.03 | blup | 49 | 0.04 | 6.6e-08 | -4.29 | -7.8 | 7.6e-15 | 0.07 | 0.70 | 0.30 | FALSE |
44 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TCP11 | 0.07 | 0.01 | enet | 8 | 0.01 | 8.2e-02 | -7.81 | -7.5 | 9.1e-14 | -0.02 | 0.06 | 0.31 | FALSE |
45 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C6orf106 | 0.09 | 0.03 | lasso | 5 | 0.05 | 3.6e-06 | -4.03 | 7.1 | 1.6e-12 | -0.03 | 0.32 | 0.05 | FALSE |
46 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TCP11 | 0.03 | 0.00 | blup | 49 | 0.01 | 8.8e-03 | -7.29 | -7.3 | 2.8e-13 | 0.02 | 0.10 | 0.07 | TRUE |
47 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C6orf106 | 0.04 | 0.01 | blup | 68 | 0.01 | 2.4e-02 | 10.96 | 11.0 | 5.2e-28 | 0.08 | 0.01 | 0.81 | FALSE |
48 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPL10A | 0.07 | 0.07 | lasso | 2 | 0.06 | 9.9e-08 | -6.12 | -6.6 | 3.9e-11 | -0.04 | 1.00 | 0.00 | TRUE |
49 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TCP11 | 0.03 | 0.02 | blup | 49 | 0.02 | 1.7e-03 | -3.99 | -7.6 | 2.4e-14 | 0.07 | 0.02 | 0.95 | FALSE |
50 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PPARD | 0.07 | 0.06 | lasso | 3 | 0.04 | 2.5e-03 | -7.26 | -6.7 | 3.0e-11 | 0.17 | 0.12 | 0.36 | FALSE |
51 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf106 | 0.04 | 0.05 | lasso | 4 | 0.03 | 8.1e-05 | 10.99 | 10.7 | 1.2e-26 | 0.09 | 0.02 | 0.98 | FALSE |
52 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TCP11 | 0.05 | 0.04 | blup | 49 | 0.06 | 1.3e-07 | -7.29 | -7.2 | 6.3e-13 | 0.05 | 0.09 | 0.91 | FALSE |
53 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ZNF76 | 0.08 | 0.05 | lasso | 10 | 0.07 | 4.9e-04 | -8.92 | -7.0 | 3.0e-12 | 0.06 | 0.05 | 0.35 | FALSE |
54 | The Cancer Genome Atlas | Lung Adenocarcinoma | C6orf106 | 0.03 | 0.03 | lasso | 3 | 0.01 | 7.6e-03 | 5.29 | 7.3 | 2.6e-13 | 0.00 | 0.02 | 0.82 | FALSE |
55 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPL10A | 0.02 | 0.02 | lasso | 2 | 0.02 | 3.8e-03 | -6.94 | -6.9 | 4.0e-12 | -0.01 | 0.08 | 0.04 | FALSE |
56 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TCP11 | 0.03 | 0.03 | blup | 49 | 0.03 | 3.5e-04 | -7.29 | -7.8 | 4.5e-15 | 0.05 | 0.07 | 0.81 | FALSE |
57 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf106 | 0.14 | 0.07 | enet | 6 | 0.06 | 1.0e-04 | 11.00 | 11.1 | 1.2e-28 | 0.08 | 0.01 | 0.97 | TRUE |
58 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TCP11 | 0.05 | 0.07 | lasso | 2 | 0.07 | 1.9e-05 | -7.13 | -7.2 | 6.1e-13 | 0.01 | 0.15 | 0.71 | FALSE |
59 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TCP11 | 0.08 | 0.11 | lasso | 2 | 0.11 | 3.4e-05 | -7.13 | -7.2 | 5.3e-13 | 0.01 | 0.11 | 0.57 | FALSE |
60 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPL10A | 0.09 | 0.03 | enet | 19 | 0.07 | 1.1e-07 | -6.43 | -8.5 | 1.9e-17 | 0.01 | 0.91 | 0.04 | FALSE |
61 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF76 | 0.03 | 0.02 | lasso | 3 | 0.02 | 3.5e-03 | -7.03 | 6.4 | 1.5e-10 | -0.06 | 0.21 | 0.34 | TRUE |
62 | The Cancer Genome Atlas | Thyroid Carcinoma | C6orf106 | 0.08 | 0.00 | enet | 15 | 0.05 | 2.5e-05 | -6.06 | 13.0 | 2.2e-38 | -0.05 | 0.03 | 0.29 | TRUE |
63 | The Cancer Genome Atlas | Thyroid Carcinoma | RPL10A | 0.05 | 0.07 | enet | 4 | 0.04 | 1.2e-04 | -6.43 | -7.3 | 3.3e-13 | -0.03 | 0.76 | 0.05 | FALSE |
64 | The Cancer Genome Atlas | Thyroid Carcinoma | TCP11 | 0.03 | 0.02 | blup | 49 | 0.02 | 1.6e-03 | -7.13 | -7.8 | 5.5e-15 | 0.04 | 0.02 | 0.82 | FALSE |