[Hub]/) : Traits : Nervous feelings :

chr16:28,825,605-31,860,399

Best TWAS P=4.53e-11 · Best GWAS P=5.54e-10 conditioned to 0.422

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PRSS36 0.14 0.09 enet 13 0.11 1.4e-13 -5.26 -5.5 5.0e-08 -0.08 0.00 0.99 FALSE
2 GTEx Adipose Subcutaneous YPEL3 0.20 0.29 lasso 9 0.30 3.8e-25 -5.19 -5.3 1.0e-07 -0.83 0.49 0.51 FALSE
3 GTEx Adipose Subcutaneous KAT8 0.19 0.17 lasso 5 0.25 4.8e-20 -5.31 -5.8 5.6e-09 -0.16 0.00 1.00 FALSE
4 GTEx Adipose Subcutaneous INO80E 0.10 0.16 enet 19 0.15 4.5e-12 -5.54 5.7 1.5e-08 0.91 0.01 0.99 FALSE
5 GTEx Adipose Visceral Omentum YPEL3 0.13 0.16 lasso 4 0.14 6.8e-08 -5.19 -5.2 2.1e-07 -0.81 0.26 0.73 FALSE
6 GTEx Adipose Visceral Omentum INO80E 0.14 0.14 enet 17 0.19 3.7e-10 -5.61 6.0 2.4e-09 0.92 0.02 0.98 FALSE
7 GTEx Adipose Visceral Omentum AC009133.12 0.05 0.01 lasso 2 0.00 2.3e-01 -5.52 -5.6 1.6e-08 -0.75 0.04 0.55 FALSE
8 GTEx Adrenal Gland INO80E 0.35 0.00 lasso 4 0.05 5.4e-03 6.20 5.2 1.7e-07 0.61 0.02 0.82 FALSE
9 GTEx Artery Aorta YPEL3 0.27 0.25 lasso 9 0.26 9.1e-15 -5.19 -5.5 4.9e-08 -0.89 0.06 0.94 FALSE
10 GTEx Artery Aorta KAT8 0.23 0.20 lasso 4 0.20 2.7e-11 4.94 -5.6 1.8e-08 -0.16 0.03 0.96 FALSE
11 GTEx Artery Aorta INO80E 0.12 0.17 enet 11 0.17 1.9e-09 6.20 6.2 4.2e-10 0.95 0.01 0.99 FALSE
12 GTEx Artery Aorta SLX1A-SULT1A3 0.07 0.00 enet 17 0.00 2.6e-01 -2.27 -5.4 7.7e-08 -0.71 0.04 0.69 FALSE
13 GTEx Artery Tibial YPEL3 0.19 0.29 lasso 5 0.27 1.5e-21 -5.19 -5.2 1.6e-07 -0.80 0.44 0.55 FALSE
14 GTEx Artery Tibial KAT8 0.30 0.23 lasso 5 0.27 3.3e-21 -5.31 -5.7 1.5e-08 -0.17 0.00 1.00 FALSE
15 GTEx Artery Tibial INO80E 0.23 0.15 enet 21 0.19 6.7e-15 -5.54 5.6 1.6e-08 0.81 0.11 0.89 FALSE
16 GTEx Brain Caudate basal ganglia PRSS36 0.16 0.25 lasso 3 0.23 2.4e-07 -5.31 -5.3 1.2e-07 -0.13 0.00 0.99 FALSE
17 GTEx Brain Cerebellar Hemisphere YPEL3 0.15 0.13 lasso 6 0.11 8.1e-04 -5.15 -5.9 3.7e-09 -0.91 0.05 0.85 FALSE
18 GTEx Brain Cerebellum YPEL3 0.16 0.17 lasso 2 0.16 1.7e-05 -5.19 -5.3 1.4e-07 -0.81 0.04 0.90 FALSE
19 GTEx Brain Cerebellum KAT8 0.21 0.01 lasso 9 0.05 1.4e-02 4.82 -5.3 1.3e-07 -0.19 0.02 0.89 FALSE
20 GTEx Brain Nucleus accumbens basal ganglia KAT8 0.19 0.13 lasso 4 0.18 1.4e-05 4.74 -5.8 7.2e-09 -0.17 0.01 0.89 FALSE
21 GTEx Brain Nucleus accumbens basal ganglia PRSS36 0.40 0.28 lasso 2 0.26 1.6e-07 -5.30 -5.3 1.1e-07 -0.13 0.00 0.99 FALSE
22 GTEx Breast Mammary Tissue YPEL3 0.16 0.25 lasso 2 0.24 1.3e-12 -5.19 -5.2 2.2e-07 -0.80 0.40 0.60 FALSE
23 GTEx Breast Mammary Tissue KAT8 0.23 0.14 lasso 10 0.17 4.4e-09 4.82 -5.9 2.9e-09 -0.16 0.02 0.98 FALSE
24 GTEx Breast Mammary Tissue INO80E 0.17 0.12 enet 14 0.13 2.3e-07 6.20 6.3 3.8e-10 0.91 0.02 0.98 FALSE
25 GTEx Breast Mammary Tissue (Male) YPEL3 0.30 0.16 lasso 3 0.18 6.2e-05 -5.25 -5.3 9.5e-08 -0.85 0.12 0.74 FALSE
26 GTEx Breast Mammary Tissue (Male) KAT8 0.13 0.01 enet 3 0.01 1.7e-01 -5.31 -6.0 1.6e-09 -0.07 0.02 0.47 FALSE
27 GTEx Breast Mammary Tissue (Female) YPEL3 0.12 0.20 lasso 2 0.16 1.5e-05 -5.19 -5.1 2.8e-07 -0.80 0.08 0.70 FALSE
28 GTEx Breast Mammary Tissue (Female) INO80E 0.20 0.13 lasso 7 0.06 7.3e-03 6.20 6.3 3.5e-10 0.97 0.01 0.90 FALSE
29 GTEx Cells Transformed fibroblasts YPEL3 0.09 0.09 enet 2 0.09 3.2e-07 -5.15 -5.2 2.2e-07 -0.79 0.44 0.55 FALSE
30 GTEx Cells Transformed fibroblasts MAPK3 0.12 0.05 lasso 10 0.04 3.7e-04 4.19 5.3 1.4e-07 0.76 0.16 0.82 FALSE
31 GTEx Cells Transformed fibroblasts KAT8 0.31 0.31 lasso 4 0.32 1.9e-24 -5.30 -5.7 1.2e-08 -0.15 0.00 1.00 FALSE
32 GTEx Cells Transformed fibroblasts PPP4C 0.04 0.06 lasso 1 0.05 8.0e-05 -5.55 5.6 2.8e-08 0.82 0.09 0.87 FALSE
33 GTEx Cells Transformed fibroblasts RP11-455F5.3 0.05 0.07 lasso 2 0.06 1.7e-05 -5.19 -5.2 2.0e-07 -0.79 0.13 0.80 FALSE
34 GTEx Colon Sigmoid KAT8 0.20 0.10 lasso 3 0.14 1.0e-05 4.94 -5.9 4.1e-09 -0.16 0.02 0.93 FALSE
35 GTEx Colon Transverse YPEL3 0.27 0.26 lasso 4 0.25 2.7e-12 -5.15 -5.2 2.1e-07 -0.80 0.25 0.75 FALSE
36 GTEx Colon Transverse KAT8 0.14 0.12 lasso 6 0.05 1.4e-03 -5.31 -5.7 1.3e-08 -0.15 0.00 0.99 FALSE
37 GTEx Colon Transverse RP11-231C14.4 0.07 0.04 enet 8 0.06 8.0e-04 -5.58 -5.8 5.6e-09 -0.78 0.07 0.73 FALSE
38 GTEx Colon Transverse INO80E 0.14 0.17 enet 16 0.19 3.3e-09 6.20 6.3 4.0e-10 0.96 0.01 0.99 FALSE
39 GTEx Esophagus Gastroesophageal Junction KAT8 0.18 0.11 lasso 4 0.24 4.9e-09 -5.31 -5.6 2.6e-08 -0.14 0.02 0.97 FALSE
40 GTEx Esophagus Gastroesophageal Junction INO80E 0.15 0.00 lasso 6 0.02 4.3e-02 -5.52 5.4 8.8e-08 0.66 0.07 0.65 FALSE
41 GTEx Esophagus Mucosa YPEL3 0.11 0.21 lasso 3 0.20 8.8e-14 -5.15 -5.2 2.0e-07 -0.79 0.41 0.59 FALSE
42 GTEx Esophagus Mucosa KAT8 0.21 0.15 lasso 4 0.23 3.5e-15 -5.31 -5.9 4.2e-09 -0.16 0.00 1.00 FALSE
43 GTEx Esophagus Mucosa INO80E 0.12 0.16 enet 14 0.20 4.6e-13 6.20 6.1 1.2e-09 0.93 0.00 1.00 FALSE
44 GTEx Esophagus Muscularis YPEL3 0.24 0.29 lasso 5 0.27 1.1e-16 -5.34 -5.4 8.7e-08 -0.83 0.30 0.70 FALSE
45 GTEx Esophagus Muscularis KAT8 0.29 0.19 lasso 4 0.21 1.2e-12 -5.31 -5.9 4.6e-09 -0.16 0.00 1.00 FALSE
46 GTEx Esophagus Muscularis INO80E 0.10 0.11 enet 20 0.07 4.6e-05 -5.63 5.8 7.3e-09 0.81 0.09 0.91 FALSE
47 GTEx Heart Atrial Appendage INO80E 0.14 0.17 lasso 3 0.19 5.7e-09 -5.61 6.2 7.5e-10 0.92 0.04 0.96 FALSE
48 GTEx Heart Left Ventricle YPEL3 0.12 0.02 lasso 7 0.02 4.7e-02 -5.15 -5.7 1.4e-08 -0.84 0.04 0.76 FALSE
49 GTEx Heart Left Ventricle INO80E 0.06 0.07 lasso 7 0.08 6.1e-05 -5.62 5.4 8.0e-08 0.80 0.10 0.82 FALSE
50 GTEx Lung YPEL3 0.10 0.16 lasso 4 0.16 3.2e-12 -5.19 -5.4 7.4e-08 -0.84 0.18 0.82 FALSE
51 GTEx Lung KAT8 0.14 0.08 lasso 3 0.12 1.7e-09 4.82 -6.1 1.1e-09 -0.17 0.01 0.99 TRUE
52 GTEx Lung INO80E 0.18 0.17 lasso 8 0.19 1.0e-14 6.20 6.2 5.8e-10 0.97 0.00 1.00 FALSE
53 GTEx Muscle Skeletal KAT8 0.08 0.04 enet 16 0.06 1.4e-06 -4.24 -5.3 1.3e-07 -0.13 0.01 0.99 FALSE
54 GTEx Muscle Skeletal TBX6 0.09 0.09 lasso 8 0.09 8.6e-09 -5.19 -5.2 2.4e-07 -0.81 0.38 0.62 FALSE
55 GTEx Nerve Tibial YPEL3 0.23 0.33 lasso 5 0.34 1.1e-24 -5.15 -5.3 1.3e-07 -0.81 0.49 0.51 FALSE
56 GTEx Nerve Tibial KAT8 0.17 0.06 enet 24 0.08 3.0e-06 -5.31 -5.6 2.4e-08 -0.18 0.01 0.99 FALSE
57 GTEx Nerve Tibial TBX6 0.20 0.24 lasso 7 0.24 1.2e-16 -4.89 -5.4 7.8e-08 -0.77 0.57 0.42 FALSE
58 GTEx Nerve Tibial INO80E 0.26 0.34 enet 30 0.38 3.5e-28 -5.58 6.2 4.4e-10 0.92 0.03 0.97 FALSE
59 GTEx Ovary KAT8 0.16 0.09 lasso 4 0.06 1.2e-02 4.94 -5.7 1.5e-08 -0.17 0.03 0.76 FALSE
60 GTEx Ovary INO80E 0.16 0.06 lasso 14 0.13 5.1e-04 -5.58 6.6 4.5e-11 0.84 0.03 0.88 TRUE
61 GTEx Pancreas YPEL3 0.19 0.14 lasso 6 0.18 5.7e-08 -5.19 -5.6 1.6e-08 -0.68 0.11 0.88 FALSE
62 GTEx Pituitary YPEL3 0.12 0.04 lasso 4 0.05 2.5e-02 -5.18 -5.5 4.0e-08 -0.79 0.04 0.68 FALSE
63 GTEx Pituitary KAT8 0.18 0.10 lasso 3 0.13 4.4e-04 -5.31 -5.4 8.6e-08 -0.13 0.00 0.99 FALSE
64 GTEx Pituitary INO80E 0.27 0.29 lasso 8 0.27 1.9e-07 -5.58 5.3 1.0e-07 0.79 0.10 0.89 FALSE
65 GTEx Prostate INO80E 0.18 0.23 lasso 2 0.23 1.6e-06 -5.52 5.3 1.4e-07 0.75 0.04 0.93 FALSE
66 GTEx Skin Not Sun Exposed Suprapubic YPEL3 0.22 0.27 lasso 6 0.25 8.1e-14 -5.19 -5.5 3.4e-08 -0.81 0.38 0.62 FALSE
67 GTEx Skin Not Sun Exposed Suprapubic KAT8 0.30 0.20 enet 15 0.26 1.9e-14 -5.30 -5.9 3.6e-09 -0.17 0.00 0.99 FALSE
68 GTEx Skin Not Sun Exposed Suprapubic INO80E 0.23 0.20 enet 34 0.14 2.9e-08 6.20 6.0 1.4e-09 0.83 0.00 1.00 FALSE
69 GTEx Skin Sun Exposed Lower leg YPEL3 0.20 0.26 lasso 4 0.27 2.2e-22 -5.19 -5.2 1.7e-07 -0.81 0.45 0.55 FALSE
70 GTEx Skin Sun Exposed Lower leg KAT8 0.31 0.23 lasso 6 0.35 2.2e-30 4.82 -5.8 5.2e-09 -0.17 0.01 0.99 FALSE
71 GTEx Skin Sun Exposed Lower leg INO80E 0.11 0.10 lasso 5 0.10 1.4e-08 -5.54 6.0 1.8e-09 0.94 0.03 0.97 FALSE
72 GTEx Skin Sun Exposed Lower leg RP11-455F5.3 0.06 0.05 lasso 6 0.05 9.6e-05 4.65 -5.2 2.0e-07 -0.89 0.09 0.90 FALSE
73 GTEx Small Intestine Terminal Ileum MAPK3 0.17 0.01 lasso 5 0.04 5.4e-02 -5.58 6.0 2.2e-09 0.74 0.06 0.46 FALSE
74 GTEx Small Intestine Terminal Ileum INO80E 0.20 0.14 lasso 17 0.08 6.2e-03 -4.86 5.4 7.5e-08 0.77 0.06 0.82 FALSE
75 GTEx Spleen YPEL3 0.18 0.24 enet 5 0.18 2.3e-05 -5.34 -5.4 6.6e-08 -0.84 0.08 0.84 FALSE
76 GTEx Spleen INO80E 0.23 0.20 enet 13 0.26 2.6e-07 5.98 5.9 3.6e-09 0.88 0.02 0.97 FALSE
77 GTEx Stomach YPEL3 0.12 0.09 lasso 1 0.07 2.2e-04 -5.34 -5.3 9.4e-08 -0.81 0.16 0.75 FALSE
78 GTEx Stomach KAT8 0.12 0.03 lasso 5 0.07 2.9e-04 -5.31 -5.4 6.3e-08 -0.15 0.02 0.97 FALSE
79 GTEx Stomach INO80E 0.09 0.07 enet 6 0.02 3.4e-02 6.20 6.2 6.8e-10 1.00 0.02 0.95 FALSE
80 GTEx Testis YPEL3 0.15 0.11 lasso 2 0.11 1.5e-05 -5.18 -5.3 1.1e-07 -0.91 0.02 0.97 FALSE
81 GTEx Testis INO80E 0.15 0.20 lasso 3 0.19 8.3e-09 -5.54 5.4 7.0e-08 0.81 0.10 0.90 FALSE
82 GTEx Thyroid YPEL3 0.07 0.11 lasso 4 0.10 2.6e-08 -5.34 -5.3 9.5e-08 -0.81 0.17 0.83 FALSE
83 GTEx Thyroid KAT8 0.21 0.12 lasso 6 0.15 2.2e-11 4.71 -5.5 4.0e-08 -0.17 0.03 0.97 FALSE
84 GTEx Thyroid INO80E 0.15 0.25 lasso 3 0.25 2.0e-19 6.20 6.3 3.2e-10 0.99 0.00 1.00 FALSE
85 GTEx Vagina YPEL3 0.12 0.08 lasso 2 0.06 2.1e-02 -5.19 -5.2 2.0e-07 -0.80 0.05 0.52 FALSE
86 GTEx Vagina KAT8 0.34 0.26 lasso 5 0.22 8.4e-06 -5.30 -5.4 7.8e-08 -0.14 0.00 0.96 FALSE
87 GTEx Vagina INO80E 0.24 0.23 lasso 6 0.27 7.0e-07 5.98 6.0 1.9e-09 0.97 0.02 0.97 FALSE
88 GTEx Whole Blood YPEL3 0.09 0.06 lasso 3 0.06 5.8e-06 -5.19 -5.2 2.6e-07 -0.80 0.29 0.68 FALSE
89 GTEx Whole Blood ZNF668 0.05 0.06 lasso 3 0.06 5.9e-06 4.71 5.5 4.4e-08 0.16 0.05 0.94 FALSE
90 METSIM Adipose KAT8 0.17 0.13 lasso 6 0.20 1.7e-28 4.71 -5.8 7.8e-09 -0.16 0.01 0.99 FALSE
91 METSIM Adipose YPEL3 0.16 0.21 enet 12 0.22 9.5e-33 -5.34 -5.8 7.1e-09 -0.87 0.41 0.59 FALSE
92 ROSMAP Brain Pre-frontal Cortex YPEL3 0.06 0.03 blup 209 0.04 1.9e-05 -5.14 -5.6 2.8e-08 -0.68 0.40 0.58 FALSE
93 ROSMAP Brain Pre-frontal Cortex SETD1A 0.02 0.01 blup 232 0.02 4.3e-04 -2.44 -5.5 3.9e-08 -0.16 0.10 0.70 FALSE
94 ROSMAP Brain Pre-frontal Cortex KAT8 0.13 0.16 lasso 5 0.16 4.2e-20 4.74 -5.4 6.9e-08 -0.17 0.05 0.94 FALSE
95 ROSMAP Brain Pre-frontal Cortex PPP4C 0.15 0.30 lasso 4 0.31 3.1e-40 -5.19 5.5 4.1e-08 0.87 0.49 0.51 FALSE
96 ROSMAP Brain Pre-frontal Cortex INO80E 0.08 0.13 lasso 2 0.12 1.6e-15 -5.58 5.6 2.6e-08 0.82 0.10 0.90 FALSE
97 ROSMAP Brain Pre-frontal Cortex PRSS36 0.14 0.12 bslmm 241 0.12 1.1e-15 -5.31 -5.8 7.2e-09 -0.12 0.00 1.00 FALSE
98 ROSMAP Brain Pre-frontal Cortex RP11-345J4.8 0.02 0.00 blup 192 0.01 1.9e-02 -0.81 -5.8 7.4e-09 -0.67 0.03 0.12 FALSE
99 YFS Blood INO80E 0.02 0.02 lasso 5 0.02 3.7e-07 -4.95 5.2 2.2e-07 0.73 0.08 0.92 FALSE
100 YFS Blood PPP4C 0.03 0.05 lasso 4 0.05 4.0e-15 -5.19 5.4 5.3e-08 0.81 0.43 0.57 FALSE
101 The Cancer Genome Atlas Bladder Urothelial Carcinoma MYST1 0.04 0.03 enet 4 0.03 1.2e-03 -5.31 -5.9 3.8e-09 -0.16 0.00 0.95 FALSE
102 The Cancer Genome Atlas Breast Invasive Carcinoma MYST1 0.05 0.04 blup 34 0.08 2.1e-15 -5.30 -5.7 1.3e-08 -0.15 0.00 1.00 FALSE
103 The Cancer Genome Atlas Esophageal Carcinoma PPP4C 0.08 0.04 blup 23 0.05 8.9e-03 -5.21 5.7 1.5e-08 0.88 0.01 0.79 FALSE
104 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MYST1 0.08 0.04 blup 34 0.07 7.2e-08 4.94 -5.6 2.6e-08 -0.16 0.03 0.97 FALSE
105 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MYST1 0.12 0.09 blup 34 0.10 2.8e-11 -5.30 -5.7 9.5e-09 -0.16 0.00 1.00 FALSE
106 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MYST1 0.07 0.01 enet 6 0.04 1.6e-03 4.82 -5.2 2.4e-07 -0.14 0.03 0.69 FALSE
107 The Cancer Genome Atlas Brain Lower Grade Glioma MYST1 0.16 0.08 blup 34 0.12 1.5e-13 4.82 -5.8 8.3e-09 -0.17 0.02 0.98 FALSE
108 The Cancer Genome Atlas Lung Adenocarcinoma DOC2A 0.01 0.02 lasso 2 0.02 2.5e-03 5.98 6.1 1.4e-09 0.97 0.01 0.83 FALSE
109 The Cancer Genome Atlas Lung Adenocarcinoma MYST1 0.09 0.03 blup 33 0.03 1.4e-04 -5.30 -5.9 4.2e-09 -0.16 0.00 0.99 FALSE
110 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MYST1 0.08 0.08 enet 8 0.08 2.8e-09 -5.31 -5.4 5.3e-08 -0.14 0.00 1.00 FALSE
111 The Cancer Genome Atlas Pancreatic Adenocarcinoma MYST1 0.22 0.15 blup 36 0.21 2.1e-09 4.82 -5.4 6.0e-08 -0.16 0.05 0.94 FALSE
112 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma MYST1 0.07 0.09 lasso 3 0.07 1.0e-03 -5.26 -5.6 2.4e-08 -0.14 0.01 0.88 FALSE
113 The Cancer Genome Atlas Prostate Adenocarcinoma FAM57B 0.04 0.05 enet 6 0.04 1.1e-04 -5.19 5.3 8.8e-08 0.87 0.13 0.82 FALSE
114 The Cancer Genome Atlas Prostate Adenocarcinoma MYST1 0.19 0.12 blup 33 0.18 1.5e-18 4.74 -5.6 2.2e-08 -0.16 0.03 0.97 FALSE
115 The Cancer Genome Atlas Prostate Adenocarcinoma PRSS36 0.17 0.13 blup 27 0.14 1.0e-14 -5.26 -5.7 1.1e-08 -0.15 0.00 1.00 FALSE
116 The Cancer Genome Atlas Rectum Adenocarcinoma MYST1 0.13 0.05 blup 35 0.06 1.9e-02 4.82 -5.4 6.5e-08 -0.16 0.01 0.48 FALSE
117 The Cancer Genome Atlas Stomach Adenocarcinoma MYST1 0.04 0.02 blup 35 0.02 8.7e-03 -5.31 -5.6 2.2e-08 -0.16 0.00 0.83 FALSE
118 The Cancer Genome Atlas Testicular Germ Cell Tumors MYST1 0.13 0.06 blup 34 0.12 6.8e-05 4.80 -5.5 4.9e-08 -0.16 0.02 0.91 FALSE
119 The Cancer Genome Atlas Thyroid Carcinoma DOC2A 0.03 0.02 blup 48 0.03 6.1e-04 -5.58 5.2 2.6e-07 0.72 0.08 0.54 FALSE
120 The Cancer Genome Atlas Thyroid Carcinoma FAM57B 0.06 0.05 blup 47 0.06 1.9e-06 -5.25 5.2 2.5e-07 0.91 0.05 0.95 FALSE
121 The Cancer Genome Atlas Thyroid Carcinoma MYST1 0.12 0.10 lasso 3 0.14 1.1e-13 4.83 -5.8 6.0e-09 -0.17 0.02 0.98 FALSE