[Hub]/) : Traits : Tense / 'highly strung' : ← →

chr8:8,092,025-12,966,739

Best TWAS P=3.78e-13 · Best GWAS P=5.68e-11 conditioned to 0.00626

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ERI1	0.06	0.04	lasso	3	0.04	9.0e-06	5.0	5.3	1.2e-07	0.36	0.73	0.27	FALSE
2	GTEx	Adipose Subcutaneous	AF131215.2	0.24	0.15	lasso	7	0.14	3.5e-11	6.2	-6.5	1.0e-10	-0.58	0.04	0.96	FALSE
3	GTEx	Adipose Subcutaneous	AF131215.9	0.20	0.12	enet	60	0.17	1.1e-13	6.2	-5.4	7.3e-08	-0.42	0.03	0.97	FALSE
4	GTEx	Adipose Visceral Omentum	FAM86B3P	0.23	0.07	enet	20	0.14	6.4e-08	-6.1	-5.8	5.7e-09	-0.55	0.06	0.94	FALSE
5	GTEx	Adipose Visceral Omentum	AF131215.2	0.12	0.08	lasso	6	0.06	4.6e-04	-6.2	-6.7	2.2e-11	-0.60	0.03	0.96	FALSE
6	GTEx	Adipose Visceral Omentum	AF131215.9	0.18	0.16	lasso	7	0.16	2.0e-08	-6.2	-6.5	7.6e-11	-0.60	0.04	0.96	FALSE
7	GTEx	Adrenal Gland	AF131215.2	0.20	0.16	enet	12	0.13	2.2e-05	-5.9	-6.2	5.7e-10	-0.60	0.10	0.90	FALSE
8	GTEx	Adrenal Gland	AF131215.9	0.18	0.16	lasso	10	0.18	3.5e-07	-5.9	-6.1	1.2e-09	-0.62	0.10	0.90	FALSE
9	GTEx	Artery Aorta	AF131215.2	0.09	0.09	lasso	7	0.08	2.0e-05	6.2	-6.5	6.2e-11	-0.60	0.07	0.92	FALSE
10	GTEx	Artery Aorta	AF131215.9	0.13	0.05	lasso	6	0.07	1.3e-04	-5.4	-6.3	3.7e-10	-0.60	0.11	0.89	FALSE
11	GTEx	Artery Tibial	ERI1	0.05	0.02	lasso	7	0.01	3.2e-02	-5.0	5.3	1.3e-07	0.60	0.29	0.45	FALSE
12	GTEx	Artery Tibial	AF131215.2	0.07	0.03	enet	24	0.05	1.8e-04	6.3	-6.6	5.0e-11	-0.54	0.06	0.93	FALSE
13	GTEx	Artery Tibial	AF131215.9	0.08	0.01	lasso	10	0.02	1.8e-02	5.7	-6.3	2.9e-10	-0.52	0.05	0.92	FALSE
14	GTEx	Brain Cerebellar Hemisphere	FAM86B3P	0.28	0.27	lasso	8	0.28	5.4e-08	-6.3	6.5	7.2e-11	0.62	0.02	0.97	FALSE
15	GTEx	Brain Cerebellar Hemisphere	AF131215.2	0.15	0.17	lasso	3	0.09	3.0e-03	6.3	-6.5	7.9e-11	-0.54	0.06	0.81	FALSE
16	GTEx	Brain Cerebellum	FAM86B3P	0.19	0.14	lasso	5	0.16	1.8e-05	-5.8	6.2	4.2e-10	0.62	0.04	0.95	FALSE
17	GTEx	Brain Cortex	FAM86B3P	0.14	0.05	enet	9	0.07	5.1e-03	-5.6	5.9	2.9e-09	0.60	0.12	0.45	FALSE
18	GTEx	Brain Frontal Cortex BA9	FAM86B3P	0.16	0.13	enet	27	0.10	1.1e-03	-5.1	5.4	5.9e-08	0.55	0.05	0.88	FALSE
19	GTEx	Breast Mammary Tissue	AF131215.2	0.16	0.15	lasso	6	0.12	1.1e-06	6.2	-6.3	2.1e-10	-0.63	0.05	0.94	FALSE
20	GTEx	Breast Mammary Tissue	AF131215.9	0.10	0.10	lasso	8	0.12	8.7e-07	5.4	-6.6	5.1e-11	-0.62	0.09	0.91	FALSE
21	GTEx	Breast Mammary Tissue (Male)	AF131215.2	0.31	0.08	enet	23	0.03	5.9e-02	6.2	-5.8	8.6e-09	-0.53	0.10	0.32	FALSE
22	GTEx	Breast Mammary Tissue (Female)	AF131215.2	0.04	-0.01	lasso	2	0.00	4.8e-01	5.4	-5.4	5.8e-08	-0.53	0.06	0.24	FALSE
23	GTEx	Breast Mammary Tissue (Female)	AF131215.9	0.04	-0.01	enet	6	0.02	7.3e-02	4.5	-5.4	7.4e-08	-0.59	0.07	0.25	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	AF131215.2	0.20	0.10	enet	14	0.11	1.5e-04	6.3	-6.1	1.1e-09	-0.59	0.04	0.95	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	AF131215.9	0.20	0.15	enet	19	0.13	5.6e-05	6.3	-6.0	2.6e-09	-0.57	0.03	0.96	FALSE
26	GTEx	Cells Transformed fibroblasts	FAM86B3P	0.23	0.33	lasso	11	0.38	8.4e-30	-5.9	-6.3	3.3e-10	-0.62	0.11	0.89	FALSE
27	GTEx	Colon Sigmoid	MTMR9	0.24	0.18	lasso	4	0.14	1.6e-05	4.9	-5.2	2.0e-07	-0.48	0.80	0.07	FALSE
28	GTEx	Colon Sigmoid	AF131215.2	0.10	0.00	enet	7	0.02	5.0e-02	-6.1	-6.3	2.5e-10	-0.62	0.07	0.73	FALSE
29	GTEx	Colon Sigmoid	AF131215.9	0.11	0.17	enet	5	0.09	4.9e-04	6.3	-6.4	1.4e-10	-0.55	0.04	0.92	FALSE
30	GTEx	Colon Transverse	FAM86B3P	0.13	0.04	lasso	8	0.04	4.4e-03	-5.8	-5.2	1.6e-07	-0.59	0.09	0.69	FALSE
31	GTEx	Colon Transverse	AF131215.2	0.15	0.09	enet	32	0.07	3.1e-04	-5.4	-5.3	1.0e-07	-0.49	0.08	0.90	FALSE
32	GTEx	Colon Transverse	AF131215.9	0.12	0.14	enet	18	0.12	4.0e-06	6.3	-6.7	2.9e-11	-0.55	0.03	0.97	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	AF131215.2	0.13	0.06	enet	10	0.11	6.4e-05	-4.7	-5.4	6.7e-08	-0.62	0.08	0.86	FALSE
34	GTEx	Esophagus Mucosa	FAM86B3P	0.22	0.17	lasso	8	0.19	1.7e-12	-5.9	-6.7	2.9e-11	-0.61	0.10	0.90	FALSE
35	GTEx	Esophagus Mucosa	AF131215.2	0.15	0.14	enet	15	0.18	4.3e-12	5.9	-6.7	1.6e-11	-0.59	0.10	0.90	FALSE
36	GTEx	Esophagus Mucosa	AF131215.9	0.18	0.16	lasso	14	0.19	1.6e-12	-6.5	-6.9	6.5e-12	-0.61	0.02	0.98	FALSE
37	GTEx	Esophagus Muscularis	ERI1	0.12	0.09	enet	13	0.08	7.7e-06	-3.8	5.5	4.8e-08	0.59	0.78	0.21	FALSE
38	GTEx	Esophagus Muscularis	AF131215.2	0.10	0.08	lasso	5	0.09	2.3e-06	6.0	-5.8	8.5e-09	-0.52	0.10	0.90	FALSE
39	GTEx	Esophagus Muscularis	AF131215.9	0.14	0.17	enet	16	0.17	1.6e-10	6.3	-6.8	7.2e-12	-0.59	0.02	0.98	FALSE
40	GTEx	Heart Atrial Appendage	AF131215.2	0.39	0.13	enet	26	0.21	6.6e-10	6.0	-5.7	1.1e-08	-0.56	0.06	0.94	FALSE
41	GTEx	Heart Left Ventricle	AF131215.2	0.05	0.01	enet	11	0.01	1.5e-01	-6.2	-6.6	3.8e-11	-0.61	0.05	0.89	FALSE
42	GTEx	Heart Left Ventricle	AF131215.9	0.07	0.10	enet	8	0.10	9.4e-06	6.3	-6.6	4.2e-11	-0.57	0.02	0.98	FALSE
43	GTEx	Lung	ERI1	0.13	0.07	lasso	6	0.09	2.7e-07	5.1	6.0	2.6e-09	0.60	0.20	0.80	FALSE
44	GTEx	Lung	AF131215.2	0.12	0.08	lasso	5	0.08	1.0e-06	6.3	-6.5	6.7e-11	-0.53	0.02	0.98	FALSE
45	GTEx	Lung	AF131215.9	0.15	0.18	lasso	4	0.15	1.5e-11	6.3	-6.4	1.6e-10	-0.51	0.02	0.98	FALSE
46	GTEx	Nerve Tibial	AF131215.2	0.19	0.18	lasso	12	0.23	3.5e-16	6.0	-6.5	1.0e-10	-0.57	0.07	0.93	FALSE
47	GTEx	Nerve Tibial	AF131215.9	0.17	0.17	lasso	4	0.18	5.0e-13	6.3	-6.3	2.5e-10	-0.51	0.02	0.98	FALSE
48	GTEx	Pancreas	ERI1	0.08	0.00	enet	16	0.04	6.6e-03	-4.7	5.3	1.4e-07	0.55	0.19	0.17	FALSE
49	GTEx	Pancreas	AF131215.2	0.16	0.16	enet	17	0.15	9.1e-07	6.3	-6.8	9.9e-12	-0.59	0.05	0.95	FALSE
50	GTEx	Pancreas	AF131215.9	0.25	0.24	enet	14	0.22	1.0e-09	-5.4	-6.3	4.0e-10	-0.59	0.06	0.94	FALSE
51	GTEx	Pituitary	FAM86B3P	0.13	0.15	lasso	4	0.13	3.5e-04	5.1	5.5	3.3e-08	0.53	0.04	0.85	FALSE
52	GTEx	Prostate	AF131215.2	0.18	0.02	lasso	6	0.02	9.6e-02	-6.2	-7.0	3.5e-12	-0.57	0.08	0.52	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.2	0.16	0.11	enet	21	0.20	3.9e-11	5.9	-6.6	3.5e-11	-0.59	0.05	0.95	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.9	0.17	0.14	lasso	8	0.19	9.4e-11	6.3	-6.7	3.0e-11	-0.58	0.04	0.96	FALSE
55	GTEx	Skin Sun Exposed Lower leg	AF131215.2	0.14	0.11	lasso	9	0.16	4.3e-13	5.9	-6.6	3.5e-11	-0.55	0.11	0.89	FALSE
56	GTEx	Skin Sun Exposed Lower leg	AF131215.9	0.19	0.17	enet	29	0.21	3.9e-17	6.3	-7.3	3.8e-13	-0.60	0.03	0.97	TRUE
57	GTEx	Small Intestine Terminal Ileum	AF131215.2	0.14	0.07	lasso	3	0.07	1.1e-02	4.7	-6.0	2.1e-09	-0.54	0.09	0.62	FALSE
58	GTEx	Spleen	AF131215.2	0.16	0.08	enet	14	0.06	1.1e-02	6.3	-6.9	3.9e-12	-0.61	0.06	0.86	FALSE
59	GTEx	Spleen	AF131215.9	0.34	0.23	enet	16	0.15	1.2e-04	-5.9	-6.7	1.6e-11	-0.62	0.08	0.88	FALSE
60	GTEx	Stomach	AF131215.2	0.25	0.03	enet	22	0.14	5.2e-07	5.8	-6.1	9.0e-10	-0.51	0.07	0.93	FALSE
61	GTEx	Stomach	AF131215.9	0.14	0.06	enet	19	0.06	6.7e-04	6.3	-6.3	2.3e-10	-0.52	0.04	0.95	FALSE
62	GTEx	Testis	FAM86B3P	0.15	0.14	lasso	7	0.13	2.2e-06	-5.6	5.8	5.8e-09	0.61	0.07	0.93	FALSE
63	GTEx	Testis	SGK223	0.29	0.02	enet	19	0.07	3.5e-04	-6.5	6.2	4.9e-10	0.44	0.01	0.96	FALSE
64	GTEx	Testis	AF131215.2	0.28	0.18	enet	41	0.17	8.0e-08	5.9	-6.0	2.2e-09	-0.45	0.13	0.87	FALSE
65	GTEx	Testis	AF131215.9	0.12	0.21	lasso	4	0.14	5.6e-07	5.9	-5.8	7.5e-09	-0.48	0.07	0.93	FALSE
66	GTEx	Thyroid	SGK223	0.19	0.35	enet	16	0.36	1.1e-28	-5.1	5.9	3.7e-09	0.64	0.89	0.11	FALSE
67	GTEx	Thyroid	AF131215.2	0.11	0.15	enet	17	0.18	1.2e-13	5.9	-6.7	2.4e-11	-0.57	0.04	0.96	FALSE
68	GTEx	Thyroid	AF131215.9	0.11	0.08	enet	16	0.17	4.7e-13	6.3	-6.5	1.0e-10	-0.57	0.02	0.98	FALSE
69	GTEx	Uterus	AF131215.2	0.17	0.07	enet	13	0.09	7.1e-03	-5.9	-6.1	1.3e-09	-0.64	0.10	0.63	FALSE
70	GTEx	Uterus	AF131215.9	0.16	-0.01	enet	18	0.03	7.5e-02	-5.6	-6.2	6.3e-10	-0.56	0.10	0.58	FALSE
71	GTEx	Vagina	AF131215.9	0.21	0.11	lasso	9	0.08	6.3e-03	-5.6	-6.3	3.7e-10	-0.59	0.08	0.85	FALSE
72	GTEx	Whole Blood	AF131215.9	0.16	0.00	enet	19	0.01	3.8e-02	4.7	-5.3	1.0e-07	-0.46	0.10	0.75	FALSE
73	NTR	Blood	MFHAS1	0.02	0.01	blup	759	0.01	2.9e-04	-5.3	-5.4	5.4e-08	-0.60	0.67	0.31	FALSE
74	NTR	Blood	MSRA	0.02	0.01	blup	833	0.01	2.3e-05	-4.5	5.7	1.2e-08	0.75	0.09	0.91	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	FAM167A	0.12	0.03	bslmm	620	0.08	1.3e-10	-4.5	5.6	2.3e-08	0.54	0.31	0.69	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	XKR6	0.11	0.10	enet	23	0.13	1.2e-16	6.0	-6.7	3.0e-11	-0.61	0.10	0.90	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	FAM86B3P	0.19	0.27	bslmm	331	0.27	5.6e-35	-5.6	5.5	3.3e-08	0.51	0.35	0.65	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	FAM66A	0.23	0.26	enet	29	0.30	4.7e-39	-4.6	-5.2	2.3e-07	-0.56	0.02	0.97	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	FAM85B	0.16	0.23	enet	18	0.22	1.8e-28	-6.0	6.0	2.5e-09	0.62	0.11	0.89	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	AF131215.3	0.08	0.10	lasso	7	0.12	8.3e-16	-5.5	-6.3	2.6e-10	-0.62	0.06	0.94	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	AF131215.2	0.49	0.57	lasso	7	0.57	9.0e-89	6.3	-6.4	1.2e-10	-0.52	0.02	0.98	FALSE
82	ROSMAP	Brain Pre-frontal Cortex	FAM85A	0.11	0.07	enet	23	0.11	4.3e-14	-4.6	-5.2	2.3e-07	-0.56	0.01	0.98	FALSE
83	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLJ10661	0.10	0.16	lasso	1	0.15	6.1e-13	-5.8	-5.8	6.2e-09	-0.58	0.00	1.00	FALSE
84	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ10661	0.15	0.26	lasso	4	0.23	3.0e-13	-5.8	-6.0	2.5e-09	-0.59	0.00	1.00	FALSE
85	The Cancer Genome Atlas	Esophageal Carcinoma	FLJ10661	0.20	0.23	lasso	2	0.23	5.6e-08	-5.1	-5.5	4.2e-08	-0.57	0.01	0.99	FALSE
86	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ10661	0.07	0.14	lasso	3	0.14	3.7e-15	-5.8	-5.8	6.4e-09	-0.58	0.00	1.00	FALSE
87	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ10661	0.07	0.02	blup	42	0.04	2.9e-03	-5.7	-5.5	2.9e-08	-0.57	0.01	0.92	FALSE
88	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ10661	0.21	0.26	lasso	9	0.30	2.3e-34	-5.8	6.2	6.2e-10	0.59	0.01	0.99	FALSE
89	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FLJ10661	0.09	0.07	blup	41	0.07	3.6e-04	4.9	-5.5	4.5e-08	-0.53	0.04	0.58	FALSE
90	The Cancer Genome Atlas	Lung Adenocarcinoma	ERI1	0.06	0.04	blup	72	0.04	1.5e-05	-4.9	5.3	1.2e-07	0.49	0.12	0.86	FALSE
91	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ10661	0.06	0.05	lasso	3	0.04	2.4e-05	-5.7	-5.6	2.0e-08	-0.55	0.01	0.98	FALSE
92	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLJ10661	0.12	0.09	lasso	4	0.08	4.7e-09	-6.0	-5.3	1.4e-07	-0.53	0.00	1.00	FALSE
93	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLJ10661	0.25	0.18	lasso	4	0.16	4.2e-07	-5.1	5.5	5.1e-08	0.59	0.06	0.94	FALSE
94	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLJ10661	0.08	0.05	blup	42	0.07	9.3e-06	-5.7	-6.1	1.1e-09	-0.57	0.01	0.99	FALSE
95	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ10661	0.24	0.36	enet	8	0.35	4.1e-13	-5.8	-5.9	2.9e-09	-0.56	0.00	1.00	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	SGK223	0.16	0.20	enet	14	0.22	6.1e-21	5.3	6.1	1.4e-09	0.56	0.22	0.78	FALSE