Hub : Genes

FAM167A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0920	0.0280	2.2e-11	0.092	0.102	0.130	0.116	0.130	3.0e-11	1.9e-12	1.7e-15	5.9e-14	1.4e-15
2	METSIM	Adipose	0.0754	0.0248	1.7e-04	0.032	0.018	0.035	0.028	0.040	1.2e-05	8.7e-04	5.3e-06	3.5e-05	1.1e-06
3	ROSMAP	Brain Pre-frontal Cortex	0.1166	0.0373	4.4e-09	0.034	0.079	0.077	0.081	0.067	2.9e-05	2.2e-10	4.4e-10	1.3e-10	5.0e-09
4	TCGA	Breast Invasive Carcinoma	0.0709	0.0237	5.9e-06	0.009	0.031	0.023	NA	0.021	4.9e-03	4.8e-07	1.1e-05	NA	2.8e-05
5	TCGA	Lung Adenocarcinoma	0.0642	0.0300	1.6e-03	0.043	0.024	0.015	NA	0.034	8.2e-06	6.7e-04	5.6e-03	NA	6.0e-05
6	TCGA	Pancreatic Adenocarcinoma	0.0920	0.0490	6.5e-03	0.045	0.065	0.049	NA	0.080	5.7e-03	1.1e-03	4.1e-03	NA	3.0e-04
7	TCGA	Pheochromocytoma and Paraganglioma	0.2880	0.0850	7.8e-07	0.241	0.166	0.264	NA	0.269	5.0e-10	3.8e-07	6.0e-11	NA	3.5e-11
8	TCGA	Thyroid Carcinoma	0.3640	0.0620	8.4e-11	0.100	0.137	0.174	NA	0.139	5.7e-10	3.1e-13	1.2e-16	NA	2.0e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	0.8	1.2	2.7	-0.9	1.0	-1.3	1.0	0.6	0.3	1.7	1.4
Bipolar Disorder or Schizophrenia	1.5	3.5	6.7	-2.6	1.4	-2.2	2.0	1.7	1.2	2.5	-0.1
Depressed Affect (Nagel 2018)	1.0	2.1	4.1	1.2	-0.3	2.0	0.8	-2.0	-1.7	-1.0	1.7
Depression (Nagel 2018)	0.6	0.8	4.1	-1.1	0.3	0.9	-0.1	-2.0	0.3	0.2	0.5
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.7	1.1	0.6	1.2	-1.6	-0.8	-1.4	-1.0	-0.9
Neuroticism (Nagel 2018)	1.1	2.5	5.0	1.8	-0.9	2.2	1.3	-1.3	-1.5	-0.4	2.2
Schizophrenia (2018)	1.4	3.0	6.7	-2.6	1.0	-1.8	1.8	1.8	1.3	1.9	-1.1
Schizophrenia vs Biploar Disorder	1.2	1.6	4.4	-2.1	1.1	-0.8	-0.3	-0.1	0.6	1.6	-2.0
Worry (Nagel 2018)	1.5	3.1	10.4	1.7	-0.9	1.8	3.2	-0.3	-0.3	1.2	2.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.5	0.2	-0.0	0.4	0.0	0.2	0.6	0.4
Alzheimer’s Disease (in father)	1.0	1.0	4.0	1.0	-0.4	1.1	0.2	-1.2	-0.3	-0.7	2.0
Alzheimer’s Disease (including proxy)	0.3	0.4	1.2	0.5	-0.2	0.9	-0.0	-0.8	-0.3	-0.4	1.1
Crohns Disease (2017)	1.3	2.8	6.7	-1.7	0.2	-1.5	2.2	1.9	1.6	2.6	0.1
Irritable Bowel Disease (IBD)	0.8	1.9	3.6	-1.3	-0.4	-1.2	1.7	1.9	1.2	1.8	1.0
Ulcerative Colitis (UC)	0.4	0.7	1.8	-0.3	-0.9	-0.0	0.7	1.1	0.8	0.6	1.4
Major Depression (MDD)	0.4	0.5	1.6	-0.8	0.6	-0.8	-0.5	-1.3	0.6	-0.1	0.3
Reaction Time	0.2	0.3	1.0	0.6	0.2	-0.0	0.2	0.1	-0.2	-0.9	1.0
Verbal and Numeric Reasoning (VNR)	1.0	2.4	7.6	2.2	0.1	1.7	-1.3	-0.1	-2.8	-1.4	-0.4
Breast Cancer	2.0	4.8	10.1	-3.2	0.1	-3.1	-2.4	0.1	2.0	1.8	-2.3
Ovarian Cancer	0.4	0.5	1.5	-0.2	-0.8	-0.8	0.4	0.1	1.1	1.2	-0.0
Prostate Cancer	1.1	1.5	5.4	-2.3	-0.1	-1.9	-0.6	-0.3	1.0	1.4	-0.3
Age at First Birth	1.8	2.7	7.3	1.5	0.8	2.7	-0.4	-1.2	-2.7	-1.4	0.8
Bipolar Disorder (2011)	0.2	0.2	0.8	-0.5	0.3	-0.2	0.6	0.9	-0.4	0.0	0.0
Body Mass Index (BMI) (2010)	1.8	2.4	8.0	-2.1	-0.1	-2.8	0.0	0.9	1.7	1.8	0.1
Coronary Artery Disease (CAD)	0.3	0.4	1.2	0.1	0.6	0.8	-1.1	0.7	0.6	-0.3	0.1
Crohns Disease (2012)	0.8	1.3	3.3	-0.8	0.7	-0.4	1.7	1.8	0.8	1.5	0.6
Mean Putamen Volume	0.7	0.8	2.1	-1.4	1.5	-1.2	-0.6	-0.5	-0.5	0.4	-0.4
Fasting Glucose	0.8	1.0	1.7	-0.9	1.1	-1.1	1.3	-1.1	0.2	1.0	1.0
HbA1C	1.3	1.4	3.9	-1.6	1.0	-0.5	-0.3	-1.2	0.5	1.3	-2.0
HDL Cholesterol	0.5	0.8	1.6	0.7	0.1	1.0	-1.1	-0.8	-0.7	-1.1	-1.3
LDL Cholesterol	0.8	1.3	3.3	-0.0	-1.7	0.0	0.6	1.8	1.1	0.4	1.5
Lupus	8.4	12.8	67.0	-3.2	8.2	-4.0	0.7	-0.3	-0.0	2.8	-0.4
Neuroticism (2016)	14.6	21.1	59.3	7.7	-2.4	5.8	-1.8	-3.2	-4.4	-5.8	1.9
Primary Biliary Cirrhosis	1.2	1.8	7.2	-0.7	0.4	-0.8	1.4	2.7	0.7	1.4	-1.0
Rheumatoid Arthritis	3.2	4.4	25.5	1.0	5.1	1.1	2.2	-0.2	-0.5	0.6	1.5
Schizophrenia (2014)	1.6	3.5	6.8	-2.6	2.0	-1.6	2.0	2.0	1.3	2.0	-0.8
Triglycerides	2.8	4.6	10.5	2.9	-2.5	2.0	-0.8	0.3	-2.4	-3.2	1.2
Type 2 Diabetes (T2D) (2012)	1.0	1.1	4.0	-1.2	0.5	-1.4	-0.4	0.3	-0.0	1.1	-2.0
Ulcerative Colitis	0.9	1.3	4.8	0.8	-0.7	0.3	0.8	1.9	-0.3	-0.5	2.2
Blood Eosinophil Count	0.1	0.5	1.6	-0.8	-1.3	-0.8	-0.4	0.7	0.5	0.4	-0.5
Blood Platelet Count	0.2	2.3	6.4	0.7	-2.5	-0.1	2.0	1.8	1.9	0.6	0.7
Blood Red Count	0.2	2.3	5.9	-1.1	-2.4	-2.1	-0.4	1.5	1.3	-1.3	-1.2
Blood White Count	0.2	1.4	3.2	-0.3	-1.8	-1.3	1.1	1.1	1.3	0.9	1.2
Heel T-Score	0.5	3.6	8.9	-1.2	-3.0	-1.4	2.2	3.0	1.6	0.6	0.0
BMI	0.1	0.7	1.8	0.1	0.9	-0.6	-1.0	-0.2	-0.9	-1.3	0.8
Height	0.1	2.1	7.5	-0.3	-0.2	-0.1	-2.7	-2.1	1.0	-0.4	-1.9
Waist Hip Ratio (WHR)	0.3	1.3	5.3	-0.3	-2.3	-1.5	-0.1	1.0	0.7	0.5	-1.0
Systolic Blood Pressure	0.1	0.4	1.4	0.9	-0.4	-0.3	-0.1	-1.2	0.6	0.7	-0.2
Smoking Status	0.6	1.3	4.1	-0.3	0.8	0.3	-1.0	2.0	-1.7	-1.1	-0.8
Allergy or Eczema	1.3	3.4	16.4	0.7	-4.1	-1.4	0.2	2.2	1.7	-0.7	0.1
Cardiovascular Disease	0.1	0.3	0.8	-0.6	0.3	-0.8	-0.3	0.3	-0.5	0.9	-0.0
Hypothyroidism (self reported)	0.8	1.8	8.2	0.0	2.9	0.4	-0.3	0.1	-2.3	-1.1	-0.1
Respiratory disease	1.2	2.7	5.3	-0.9	-2.3	-0.5	1.9	1.7	1.6	0.8	2.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.1	-0.7	-1.8	-1.1	0.3	0.9	-0.3	0.1	0.7
Lung FEV1/FVC ratio	0.2	1.1	3.7	1.0	1.3	-0.8	1.9	1.1	0.3	-0.2	-0.3
Lung FVC	0.3	1.5	5.7	-1.2	-0.6	-2.4	0.2	1.5	1.3	0.3	-0.3
Neuroticism	0.7	1.6	3.7	0.8	-1.5	1.4	1.7	-1.1	0.3	0.7	1.9
Chronotype (morning person)	0.8	1.8	4.5	-0.1	-0.1	0.1	-2.0	-1.9	-1.4	-2.1	-0.6
Hair Pigment	0.0	1.4	4.5	0.8	-0.1	-0.9	2.1	1.1	0.9	0.9	1.4
Tanning	0.1	1.6	3.8	-1.9	-0.8	-0.9	-0.6	0.0	1.6	1.9	-1.2
Hand grip strength (left)	0.9	2.4	5.1	-1.8	2.3	-0.1	-2.1	-0.9	-1.7	0.5	-1.6
Number of treatments/medications taken	1.0	1.9	3.8	-0.3	-1.8	-1.1	1.6	1.9	0.5	1.9	0.6
Average weekly spirits intake	0.8	1.0	3.0	1.7	-1.5	-0.1	-0.2	0.5	-0.6	-1.5	-0.3
Sensitivity / hurt feelings	5.9	10.1	24.0	4.9	-2.6	4.4	-0.3	-1.1	-2.6	-3.6	3.1
Frequency of depressed mood in last 2 weeks	2.8	3.9	8.0	1.6	-1.0	2.8	-0.9	-2.4	-2.2	-2.8	0.7
Hearing difficulty/problems: Yes	0.3	0.5	1.3	1.1	-1.2	0.3	-0.5	-0.2	0.2	-0.8	-0.2
Relative age of first facial hair	0.3	0.6	1.4	0.9	-1.0	0.1	0.4	-0.8	1.2	0.6	0.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.5	0.6	1.0	0.3	-0.2	-1.0	-1.9	-0.3	0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	-0.6	0.6	-0.3	0.1	-0.7	-0.8	1.1	-0.5
Ever had hysterectomy (womb removed)	3.3	3.7	10.6	-1.9	-1.1	-2.6	0.2	0.6	1.1	2.5	-3.3
Systolic blood pressure, automated reading	4.2	12.2	25.4	-4.7	3.5	-5.0	1.8	0.4	3.3	4.8	-1.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.6	0.1	-1.2	-0.0	1.3	1.1	0.4	-0.4	1.2
Angina	0.3	0.4	1.1	-0.3	0.5	-0.0	-0.7	0.4	-0.8	-1.0	-0.4
Medication for hormone replacement therapy	0.7	0.8	2.7	-1.6	0.3	-0.8	-0.3	-1.1	0.1	1.1	-0.4
Vitamin and mineral supplements	0.4	0.6	1.3	1.1	0.7	0.0	-0.3	-0.3	-0.8	-1.0	1.0
Supplements: Zinc	1.4	1.5	3.1	-1.4	0.5	-0.0	1.6	1.1	1.1	1.8	1.4
Medication: Co-codamol	0.7	0.8	3.8	-0.8	1.0	-0.5	0.1	-0.5	0.2	1.9	-0.3
Medication: Metformin	0.9	1.3	4.8	-1.6	-0.8	-2.2	0.2	0.5	0.8	1.0	-0.9
Diabetes (father)	1.6	1.9	5.6	-2.4	-0.3	-1.6	0.4	1.6	1.4	1.6	-0.6
Diabetes (mother)	0.8	1.0	3.2	-0.7	-0.2	-1.1	1.8	1.4	0.8	0.6	0.8
Severe depression (siblings)	1.5	1.7	4.0	-0.7	1.3	-1.1	1.9	2.0	-0.2	0.2	1.5
Pack years adult smoking proportion	2.6	3.9	9.1	-1.8	0.9	-2.7	0.9	2.1	1.7	3.0	-1.7
Impedance of leg (right)	6.6	32.1	87.2	9.3	-2.9	8.4	0.2	-1.7	-6.6	-5.9	3.3
Leg fat-free mass (left)	2.5	13.2	31.3	-5.5	1.2	-5.6	-0.3	1.3	4.3	4.1	-2.4
Trunk fat percentage	0.8	3.2	7.5	-1.3	1.3	-2.4	2.1	1.1	1.3	2.7	1.1
Hand grip strength (right)	0.4	1.1	3.2	-1.1	1.8	-0.2	-1.1	-0.5	-1.0	-0.2	-1.5
Townsend deprivation index at recruitment	0.5	0.7	2.3	-0.8	0.3	-0.9	-1.4	-0.0	-0.0	0.1	-1.5
Current tobacco smoking	5.0	8.1	18.6	-3.8	0.7	-4.3	0.5	1.9	3.6	3.5	-1.6
Average weekly fortified wine intake	2.4	2.8	12.1	3.5	-1.2	2.0	1.1	0.2	-0.2	-1.6	1.1
Maternal smoking around birth	0.3	0.5	1.5	-0.1	-1.2	0.1	0.5	0.9	-0.2	-0.5	0.8
Fed-up feelings	7.7	13.9	29.5	4.6	-1.3	5.4	-1.5	-3.0	-5.4	-4.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.7	0.6	0.2	1.7	-1.1	-1.9	-1.1	-1.1	-0.3
Relative age voice broke	0.3	0.5	1.3	1.1	-0.8	0.3	-0.3	0.3	0.5	-0.3	-1.1
Taking other prescription medications	0.5	0.7	3.2	0.6	-1.8	-0.4	0.4	1.1	-0.1	0.4	0.7
Age when periods started (menarche)	1.1	2.7	5.6	1.9	0.6	1.7	-2.4	-2.0	-1.3	-1.7	-0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	-1.0	-1.2	-0.6	0.0	-0.4	0.5	1.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	15.9	36.0	72.3	-7.8	2.3	-8.3	4.5	2.2	7.4	8.5	0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.4	-0.9	1.2	-0.4	0.6	0.1	0.6	1.2	-0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.1	1.0	-0.6	1.0	0.9	0.5	-0.0	0.2	0.2
Serious illness, injury or assault to yourself	0.7	0.8	1.8	1.0	-0.1	0.9	-1.3	-1.0	-0.8	-1.0	0.4
High blood pressure	6.6	18.3	38.8	-5.8	2.1	-6.2	2.6	1.6	4.6	6.1	-1.0
Hayfever, allergic rhinitis or eczema	0.8	1.7	6.1	-0.1	-2.5	-1.3	0.8	1.6	1.6	0.2	-0.1
Multivitamins +/- minerals	0.6	0.7	1.6	-1.0	-1.0	-0.4	0.5	1.3	-0.2	0.3	-1.3
Stomach or abdominal pain in last month	4.0	5.0	13.0	3.6	-0.4	3.4	0.7	-0.2	-1.8	-2.6	2.1
Supplements: Glucosamine	0.3	0.4	1.9	-0.6	-0.4	0.3	0.2	0.7	-1.4	-0.0	-0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	0.9	-0.3	-0.5	0.0	0.4	-0.5	0.6	-0.8
Medication: Atenolol	2.1	2.7	7.3	-1.6	0.6	-2.7	1.1	1.3	1.7	2.2	-0.5
Medication: Levothyroxine sodium	6.5	10.9	24.5	4.9	-0.1	4.5	-0.7	-0.6	-4.9	-4.1	1.1
Sitting height	0.4	2.5	5.1	-2.3	1.4	-1.4	1.4	1.8	1.0	2.2	-0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	0.5	1.3	1.0	0.4	-0.7	-0.4	0.3	1.0
High blood pressure (mother)	1.0	1.4	2.2	-0.9	1.5	-1.4	1.2	1.2	0.9	1.4	-0.5
Body mass index (BMI)	5.2	22.1	53.1	-6.9	2.7	-7.3	1.9	2.3	4.9	5.9	-1.4
Impedance of leg (left)	7.1	34.3	91.0	9.5	-3.2	8.7	-0.0	-1.8	-6.8	-6.1	3.3
Leg predicted mass (left)	2.5	13.1	31.2	-5.5	1.1	-5.6	-0.2	1.4	4.3	4.1	-2.2
Trunk fat mass	1.2	5.1	12.6	-2.6	1.3	-3.6	1.7	1.2	2.2	3.3	0.2
Waist circumference	0.8	3.0	10.3	-1.9	0.2	-3.2	0.8	1.6	1.5	2.1	-0.1
Number of incorrect matches in round	0.6	0.9	3.7	1.9	-0.5	1.5	-0.3	0.1	-0.6	-0.9	0.2
Past tobacco smoking	0.9	1.7	3.6	1.9	-1.6	1.7	0.7	-1.1	-0.5	-1.3	1.0
Alcohol usually taken with meals	0.8	1.3	2.9	-1.3	-0.4	-1.7	0.1	1.4	1.6	0.4	-0.8
Nervous feelings	12.2	22.7	51.9	7.2	-2.7	7.1	-0.6	-1.7	-5.0	-6.3	2.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	3.9	1.6	-1.1	2.0	0.4	-1.7	-0.3	-1.7	1.8
Hearing difficulty/problems with background noise	1.0	1.7	5.5	2.4	-1.7	0.5	-0.4	0.7	-0.3	-2.0	0.0
Hair/balding pattern: Pattern 2	1.0	1.3	4.4	-1.9	0.3	-0.6	-0.5	-0.5	0.1	2.1	-1.1
Had menopause	1.1	1.3	3.8	-1.3	-0.1	-1.9	1.1	0.8	1.1	1.4	-0.1
Had other major operations	1.9	2.3	6.0	-1.6	0.2	-2.5	-1.0	0.5	1.6	1.7	-1.6
Forced vital capacity (FVC)	0.9	3.5	7.0	1.9	-1.2	2.3	-2.1	-0.6	-1.6	-2.7	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	16.4	37.7	72.8	-8.0	2.6	-8.4	5.2	3.2	7.2	8.5	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	0.5	-0.6	0.0	0.3	-0.5	-0.2	-0.2	-0.6
Qualifications: None of the above	0.1	0.3	1.3	-0.1	-0.0	-1.1	0.4	-0.2	0.3	0.3	0.6
Financial difficulties in last 2 years	0.3	0.4	1.8	-1.3	0.6	-0.1	-0.9	-0.0	0.0	0.6	-0.4
Mouth/teeth dental problems	1.5	2.3	4.8	1.4	-1.3	2.2	-2.0	-0.8	-1.0	-1.6	-1.2
Heart attack	0.3	0.3	0.8	0.7	0.5	0.6	0.3	0.8	-0.9	0.0	-0.1
Allergy	2.0	4.6	10.0	1.6	2.5	2.7	-1.4	-2.2	-3.2	-2.0	0.4
Pain all over the body in last month	1.0	1.1	2.9	-1.1	0.8	-1.7	0.8	0.7	1.2	1.0	-0.7
Diabetes (self-reported)	1.2	1.8	6.6	-2.6	-0.2	-2.2	0.2	0.3	0.4	1.6	-0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	0.6	-1.0	0.0	-1.1	-0.0	-0.6	-1.0	0.0
Medication: Ramipril	3.4	4.4	9.4	-2.3	-0.6	-2.7	0.8	1.8	2.8	3.1	-1.2
Medication: Simvastatin	0.4	0.6	1.5	-1.2	0.2	-1.1	0.2	0.7	-0.6	1.0	-0.3
Fluid intelligence score	1.2	2.5	4.3	1.9	-1.4	1.2	-2.1	-0.3	-2.0	-1.9	-0.4
Illnesses of siblings	1.2	1.6	6.7	0.3	-0.8	0.2	-2.6	-0.4	-0.3	-0.7	-2.2
Neuroticism score	14.5	30.3	68.7	8.2	-3.1	8.3	-0.3	-2.5	-6.0	-6.6	3.4
Weight	2.0	9.6	23.4	-4.5	1.7	-4.8	0.8	1.6	3.2	3.9	-1.3
Impedance of arm (right)	6.4	30.0	75.9	8.7	-0.9	8.6	-0.7	-3.4	-6.0	-5.7	2.9
Arm fat percentage (right)	2.2	8.8	18.2	-3.7	2.3	-4.3	2.0	1.0	3.2	4.2	0.1
Trunk fat-free mass	1.2	6.7	16.3	-4.0	0.0	-3.8	-0.4	1.2	3.1	2.7	-2.0
Hip circumference	2.0	8.4	18.7	-4.1	1.9	-4.3	1.1	1.6	2.9	3.9	-0.6
Time employed in main current job	2.6	2.9	8.1	2.8	0.6	2.7	1.0	-0.2	-1.7	-1.6	1.3
Alcohol intake versus 10 years previously	0.6	0.9	4.6	-0.3	-0.3	-0.3	-1.3	0.3	-0.6	-0.5	-2.1
Father’s age at death	4.7	6.3	13.4	3.4	-0.9	3.7	-0.8	-1.0	-2.9	-3.6	1.2
Worrier / anxious feelings	18.4	34.7	89.7	9.5	-2.2	8.4	0.8	-2.6	-6.7	-6.2	4.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.5	1.0	-0.1	1.6	-1.2	-1.4	-1.5	-1.0	-0.9
Falls in the last year	0.8	1.0	2.6	-1.6	1.3	-0.6	-1.1	-1.3	-0.3	0.6	0.1
Hair/balding pattern: Pattern 3	1.2	1.8	6.0	1.8	0.4	1.0	-0.2	0.4	-1.6	-2.5	1.1
Number of live births	0.3	0.4	0.9	0.9	0.4	0.3	-1.0	0.1	-0.5	-0.0	-1.0
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	12.9	3.4	-1.6	2.9	-2.0	-0.6	-2.2	-3.6	-1.0
Pulse rate	0.5	0.8	3.6	1.9	-0.7	0.8	0.2	-0.7	-0.7	0.1	0.9
Happiness	0.9	1.1	2.2	0.6	0.6	1.4	-0.5	-1.5	-1.4	-0.6	-1.4
Noisy workplace	0.4	0.5	1.2	0.7	-0.2	-0.2	-1.1	-0.2	-1.1	-0.8	-0.4
Qualifications: A levels/AS levels or equivalent	1.2	2.8	7.5	2.7	-0.6	1.3	0.4	0.3	-1.7	-1.8	2.4
Serious illness, injury or assault of a close relative in last 2 years	5.0	5.7	12.7	3.5	0.6	3.6	0.4	-0.5	-3.2	-3.0	1.0
Mouth/teeth dental problems: Dentures	3.6	6.1	14.1	-2.1	2.3	-3.8	2.3	1.5	2.6	2.9	1.4
Asthma	3.2	6.3	11.8	-3.4	-1.8	-2.8	1.9	2.3	3.1	2.9	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.4	2.1	-2.1	1.4	-1.2	0.8	-0.3	-1.2	-0.6
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.3	0.1	-0.4	-0.2	0.4	0.6	0.4	0.2
Depression (self-reported)	1.3	1.5	3.5	1.5	0.8	1.2	0.8	-0.2	-1.9	-1.7	1.0
Medication: Lansoprazole	0.7	0.8	1.2	0.5	1.0	1.0	1.0	0.6	-1.1	0.7	0.8
Prospective memory result	1.1	1.3	3.7	-1.1	0.9	0.1	-1.4	-1.9	-0.2	-1.1	-1.3
Lung cancer (father)	0.6	0.7	1.9	0.6	1.1	-0.6	0.6	0.9	-0.4	-0.3	1.4
Illnesses of mother	0.7	0.9	2.4	-1.0	-1.5	-1.1	-0.6	0.1	1.4	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	11.1	3.3	-1.5	2.6	-1.8	0.0	-1.9	-3.1	-0.6
Pulse wave Arterial Stiffness index	1.0	1.2	4.7	-0.9	0.2	-0.6	-1.2	-0.4	0.3	1.4	-2.2
Impedance of arm (left)	5.9	27.2	69.6	8.3	-0.5	8.1	-0.5	-3.0	-5.7	-5.3	3.4
Arm fat mass (right)	3.0	12.3	29.4	-4.9	1.8	-5.4	1.4	1.7	4.0	4.5	-1.1
Trunk predicted mass	1.2	6.7	16.6	-4.1	0.0	-3.8	-0.5	1.2	3.1	2.6	-2.1
Standing height	0.9	9.0	22.8	4.8	-1.9	4.4	-1.8	-1.0	-2.9	-3.6	0.2
Length of working week for main job	1.9	2.1	4.8	-2.2	0.5	-1.4	0.0	0.2	1.9	2.0	-1.4
Exposure to tobacco smoke at home	0.2	0.3	1.3	-0.2	1.1	-0.1	0.2	0.1	-0.7	0.4	0.1
Breastfed as a baby	1.3	1.6	4.2	1.6	0.0	1.6	-0.6	0.0	-2.0	-1.8	0.7
Tense / ‘highly strung’	7.7	12.7	31.2	4.8	-2.6	5.6	0.5	-0.9	-3.8	-4.5	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	6.6	2.6	-1.6	2.0	-0.3	-0.1	-1.5	-2.5	1.0
Hair/balding pattern: Pattern 4	0.4	0.9	3.0	0.5	-1.7	-0.0	-1.2	-0.4	0.7	-0.4	-1.3
Birth weight of first child	1.3	2.4	7.2	2.3	0.5	2.1	0.4	-2.7	-0.9	0.3	0.9
Peak expiratory flow (PEF)	2.9	6.8	14.7	3.7	-3.2	2.9	-1.7	0.7	-1.7	-3.8	-0.7
Pulse wave reflection index	1.1	1.4	5.2	-1.5	0.9	-0.5	-1.4	-0.6	-0.4	-0.1	-2.3
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.9	1.7	0.3	2.0	1.6	-0.6	-1.5	-0.6	1.4
Loud music exposure frequency	0.2	0.2	0.5	-0.5	0.0	-0.5	-0.7	-0.7	0.2	0.3	0.4
Qualifications: O levels/GCSEs or equivalent	2.3	3.7	10.4	3.2	-1.1	2.8	0.5	-1.1	-2.2	-2.0	0.4
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	5.6	-2.1	0.1	-1.6	2.3	0.8	1.4	2.4	0.1
Blood clot in the leg (DVT)	1.9	2.5	8.2	-1.1	-0.2	-2.2	0.7	1.3	2.9	1.9	-0.4
Medication: Paracetamol	1.1	1.9	4.5	1.8	-1.1	1.1	-1.4	-0.2	-2.1	-1.6	-0.2
Headache pain in last month	1.6	2.8	7.7	2.0	-0.4	2.2	-0.8	-0.9	-2.8	-1.9	0.6
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.1	1.8	-0.9	1.7	-0.8	-1.4	-1.8	-2.0	0.1
Glaucoma (self-reported)	1.3	1.5	4.5	-1.3	-1.2	-0.7	0.6	1.0	2.1	1.6	0.1
Gout (self-reported)	0.1	0.2	0.9	0.1	-0.9	-0.1	-0.3	-0.1	0.7	0.1	-0.2
Hypothyroidism/myxoedema (self-reported)	8.5	16.5	35.4	5.7	-0.1	5.6	-1.4	-1.3	-6.0	-5.3	0.7
Medication: Amlodipine	4.3	6.0	14.4	-1.5	-1.1	-3.8	2.5	2.9	2.8	2.5	1.2
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.7	-1.9	-1.0	-1.0	-0.5	1.3	1.4	1.4	0.1
Birth weight	0.3	0.6	2.2	0.7	-0.0	-1.0	-1.1	-0.2	-0.1	-0.0	-1.5
Chronic bronchitis/emphysema (mother)	0.8	1.0	3.1	-0.3	-1.0	-0.0	-1.8	-0.7	-1.4	-1.0	0.3
High blood pressure (siblings)	1.3	1.9	8.0	0.6	0.7	-0.3	2.8	0.6	0.4	1.6	1.8
Forced vital capacity (FVC), Best measure	0.5	1.8	3.1	1.6	-1.0	1.6	-1.6	0.4	-1.1	-1.8	-1.2
Body fat percentage	1.3	4.9	11.0	-2.2	1.5	-3.3	2.2	1.5	1.7	3.3	0.8
Leg fat percentage (right)	1.9	6.9	18.3	-3.0	1.2	-4.3	2.2	1.8	2.5	3.5	0.1
Arm fat-free mass (right)	2.1	10.8	27.5	-5.0	-0.2	-5.2	-0.2	2.2	3.6	3.3	-2.3
Exposure to tobacco smoke outside home	0.2	0.2	0.7	0.5	-0.6	0.1	-0.8	0.1	-0.5	-0.5	-0.2
Comparative body size at age 10	7.9	21.7	50.6	-7.1	0.4	-6.6	-0.2	1.3	6.1	4.7	-4.3
Number of full brothers	1.8	2.3	9.0	-3.0	0.5	-2.4	-1.4	-0.0	0.8	0.9	-0.5
Worry too long after embarrassment	8.4	14.1	34.8	5.9	-1.6	5.4	0.3	-0.6	-4.3	-4.6	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	1.1	0.5	1.1	0.3	-1.5	-0.5	-0.8	0.8
Wheeze or whistling in the chest in last year	1.7	3.0	7.6	-2.7	-0.6	-2.1	-0.0	-0.1	2.0	2.6	-1.1
Number of children fathered	1.3	1.4	4.8	-2.2	1.3	-0.9	-1.3	-1.0	-0.1	0.8	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.3	8.0	2.3	0.8	2.3	-0.4	-0.2	-2.8	-2.5	0.6
Age at first live birth	3.4	6.0	14.9	3.5	-0.0	3.1	0.0	0.3	-3.9	-3.2	1.0
Pulse wave peak to peak time	1.4	1.6	5.8	1.3	-0.3	1.0	1.0	0.1	-0.7	-1.7	2.4
Health satisfaction	1.9	2.4	9.3	-1.9	1.0	-1.2	1.0	-0.5	1.2	3.1	-1.3
Shortness of breath walking on level ground	1.8	2.2	5.6	-1.0	-1.8	-1.7	0.5	1.6	2.4	1.0	-0.8
Qualifications: College or University degree	0.4	1.1	2.5	0.8	-0.5	0.1	-1.4	1.3	-0.3	-1.5	-1.6
Eye problems/disorders: None of the above	1.5	1.7	7.9	0.4	0.3	0.7	-2.0	-2.8	-1.0	-0.5	-0.0
Mouth/teeth dental problems: Loose teeth	2.1	2.5	4.9	-1.6	-0.3	-2.2	1.5	-1.1	1.4	2.2	1.6
Emphysema/chronic bronchitis	5.3	6.0	12.0	-3.5	1.6	-3.1	-0.9	-0.8	2.7	2.3	-3.1
Medication for pain relief, constipation, heartburn	0.6	1.0	2.5	-1.6	1.4	-0.5	-0.1	-1.3	1.1	0.5	-0.4
Neck or shoulder pain in last month	1.0	1.4	3.9	-0.1	-2.0	-1.8	-1.6	0.6	-0.3	-0.6	-0.9
Medication: Blood pressure	3.8	6.7	14.3	-3.0	1.1	-3.8	1.8	2.1	3.4	3.1	-0.9
Angina (self-reported)	0.3	0.4	0.7	-0.6	0.7	-0.4	-0.7	0.5	-0.6	-0.8	-0.3
Migraine (self-reported)	0.5	0.7	1.4	0.5	-0.8	1.2	1.2	1.0	-0.7	-0.2	0.1
Medication: Ibuprofen	1.5	1.8	5.8	1.8	-2.4	0.9	-0.8	1.3	-0.3	-1.3	-0.7
Medication: Allopurinol	0.3	0.4	1.0	-0.7	-0.8	-0.7	-0.4	0.6	0.7	-0.1	-1.0
Medication: Omeprazole	0.5	0.6	2.9	-0.4	-1.7	-1.0	0.0	0.0	0.0	1.0	0.1
Medication: Seretide 50 evohaler	1.8	2.1	6.2	-1.4	-0.5	-1.9	-0.7	1.5	2.5	0.6	-1.2
Mean time to correctly identify matches	0.3	0.6	1.7	-0.2	1.1	-1.1	0.7	0.4	0.1	-0.1	1.3
Heart disease (mother)	3.0	3.7	13.8	1.7	2.3	2.3	0.7	-1.0	-3.7	-0.6	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.3	4.0	6.9	2.4	-1.8	2.3	-1.9	-0.6	-2.3	-2.6	-1.1
Whole body fat mass	1.8	7.4	19.5	-3.5	1.5	-4.4	1.4	1.4	2.6	3.7	-0.5
Leg fat mass (right)	2.7	10.6	29.0	-4.4	1.2	-5.4	1.5	1.8	3.5	4.2	-0.7
Arm predicted mass (right)	2.3	11.6	30.1	-5.1	-0.3	-5.5	-0.2	2.3	3.7	3.4	-2.3
Pulse rate, automated reading	0.2	0.7	1.8	-0.5	-0.1	-0.9	0.7	-1.3	0.5	1.2	0.9
Alcohol intake frequency.	0.2	0.5	2.3	-0.6	-0.3	-0.6	0.8	0.1	-1.5	0.3	0.5
Comparative height size at age 10	0.2	1.0	2.7	-0.5	-1.6	-0.6	0.1	1.4	1.3	1.2	0.2
Number of full sisters	2.5	3.0	8.6	-2.9	-0.2	-2.1	0.2	1.5	2.0	2.3	-0.5
Suffer from ‘nerves’	6.2	9.7	22.7	4.8	-2.3	4.6	-0.7	-0.9	-3.6	-3.6	1.1
Overall health rating	4.1	8.8	20.5	-4.4	0.6	-4.5	-0.3	0.4	3.0	3.9	-2.4
Chest pain or discomfort	0.7	1.0	2.5	0.4	0.3	0.3	-1.3	-0.1	-1.4	-1.6	-1.2
Had major operations	0.6	0.7	2.2	0.1	-1.4	0.1	0.8	0.6	0.6	-0.2	1.5
Age at last live birth	4.4	6.4	15.0	3.1	-0.1	3.3	-1.1	-0.2	-3.9	-3.8	0.6
Family relationship satisfaction	0.4	0.5	2.0	0.4	-0.2	0.9	-0.3	-0.3	-0.5	-1.4	0.4
Leg pain on walking	3.3	4.1	13.2	-2.8	1.4	-2.6	-1.2	1.0	0.2	0.8	-3.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.5	-1.2	-0.5	-0.7	-0.5	-0.1	0.9	0.8	-0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.5	-0.2	1.6	-0.3	-0.2	0.0	0.1	0.6	-0.9
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.3	-1.8	-0.2	-2.1	0.4	0.3	1.1	0.6	-0.5
Medication: Aspirin	3.0	3.9	11.5	-2.1	-0.7	-2.7	1.7	3.4	1.0	1.8	0.3
Supplements: Vitamin C	1.1	1.3	4.6	-2.1	1.3	-0.2	-1.0	-0.7	-0.1	1.3	-1.0
Knee pain experienced in last month	0.6	1.0	1.9	-1.4	1.2	-1.2	0.1	0.8	-0.2	1.2	-1.0
Hypertension (Self-reported)	6.8	18.8	39.3	-5.8	2.2	-6.2	2.7	1.8	4.7	6.3	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.4	0.4	-0.2	0.0	0.3	1.3	-1.6	0.4	-0.2
Illnesses of father: Heart disease	0.2	0.3	0.9	-0.2	0.5	0.3	0.6	0.9	-0.5	-0.0	-0.4
Illnesses of siblings: Diabetes	0.7	0.8	3.3	-1.8	0.7	-0.5	0.6	1.1	-0.5	-0.0	-0.8
Smoking status: Previous	0.6	0.9	2.1	-0.7	1.3	-0.5	-1.5	0.9	-0.8	-0.5	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	11.8	2.3	0.7	3.4	1.1	-1.9	-1.8	-0.6	1.7
Whole body fat-free mass	1.8	10.1	23.8	-4.9	0.5	-4.8	-0.4	1.5	3.7	3.4	-2.4
Leg fat-free mass (right)	2.4	13.0	30.5	-5.5	1.0	-5.4	-0.4	1.5	4.3	4.0	-2.4
Arm fat percentage (left)	2.5	9.9	21.5	-4.0	2.4	-4.6	2.0	1.2	3.4	4.4	0.3
Average weekly red wine intake	0.5	0.8	3.1	-1.0	1.7	-0.3	-0.5	-0.1	-0.5	-0.7	-1.0
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.7	-0.8	-0.1	-0.9	-1.2	-0.5	0.0	-0.5	-1.9
Mood swings	6.0	10.9	21.5	4.4	-2.3	4.6	-1.2	-3.0	-3.9	-3.4	1.8
Loneliness, isolation	0.8	1.0	2.0	1.4	-0.4	0.9	-0.5	-1.3	-1.4	-1.3	-0.3
Long-standing illness, disability or infirmity	0.2	0.3	1.0	-0.4	0.7	-0.1	0.8	-0.2	-0.3	1.0	0.6
Ever had bowel cancer screening	1.4	1.6	4.2	2.0	-1.9	0.8	1.5	0.2	0.1	-0.7	1.2
Diabetes diagnosed by doctor	1.0	1.6	4.8	-2.1	-0.6	-2.2	0.1	0.8	0.6	1.2	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	5.6	-1.6	1.8	-1.7	-0.6	0.9	1.4	1.1	-2.4
Friendships satisfaction	0.2	0.2	1.0	-0.2	0.1	0.1	0.1	-0.8	-1.0	0.3	-0.3
Qualifications: nursing, teaching	0.6	0.9	2.0	1.4	-0.6	0.6	1.0	1.3	-1.1	-0.6	0.9
Commuting to job workplace: Walk	1.0	1.1	4.5	-0.1	-0.0	-0.6	-2.1	-1.6	-0.7	-0.7	0.3
Eye problems/disorders: Cataract	0.9	1.1	4.7	0.4	-0.3	-0.1	2.2	1.8	-0.2	0.7	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.8	2.0	-0.3	1.5	-0.9	-0.9	-1.9	-1.9	-0.5
Medication for cholesterol	2.4	3.6	9.2	2.9	0.1	2.5	-1.1	-0.0	-1.1	-3.0	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.6	0.2	-1.7	-0.5	0.8	1.9	-0.0	0.5	0.6
Back pain experienced in last month	1.0	1.5	3.9	-0.8	-0.9	-1.5	-1.9	0.1	0.7	0.6	-2.0
Mineral and other dietary supplements	2.8	3.7	14.3	2.2	0.2	1.8	-1.6	0.3	-2.2	-3.8	0.1
Breast cancer (self-reported)	0.4	0.5	1.2	-0.7	0.6	-1.0	0.3	-0.2	0.4	1.1	-1.0
Asthma (self-reported)	3.3	6.6	12.5	-3.5	-1.8	-2.8	1.9	2.4	3.1	2.9	1.1
Osteoporosis (self-reported)	6.0	7.4	13.6	2.9	0.2	3.7	-1.8	-3.0	-3.5	-3.1	1.7
Osteoarthritis (self-reported)	0.9	1.1	2.7	-0.9	1.2	-1.6	-0.9	0.3	0.4	0.7	-1.6
Medication: Aspirin	2.2	2.8	9.1	-1.9	-0.3	-2.1	1.4	3.0	0.6	1.6	-0.3
Medication: Gliclazide	0.6	0.7	2.3	0.0	0.6	-1.1	1.5	0.4	-0.4	0.3	1.2
Illnesses of father: None of the above (group 1)	1.0	1.2	4.4	1.4	-0.4	0.0	-1.8	-0.2	0.2	-2.1	0.0
Smoking status: Current	5.1	8.2	17.0	-3.9	0.6	-4.1	1.0	2.1	3.6	3.6	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.5	11.4	3.0	-0.1	2.9	-1.6	-1.7	-3.4	-3.2	0.1
Whole body water mass	1.7	10.0	23.5	-4.8	0.6	-4.7	-0.3	1.5	3.7	3.5	-2.4
Leg predicted mass (right)	2.4	12.9	30.2	-5.5	0.9	-5.4	-0.4	1.4	4.3	4.0	-2.5
Arm fat mass (left)	2.9	11.9	28.1	-4.8	2.1	-5.3	1.5	1.5	3.7	4.5	-0.7
Number of self-reported non-cancer illnesses	0.4	0.7	1.9	-0.4	0.0	-0.2	1.4	1.1	-0.1	0.9	1.3
Average weekly champagne plus white wine intake	0.9	1.2	5.7	0.6	0.3	0.1	2.4	1.4	-0.9	0.5	0.8
Miserableness	8.6	15.0	35.2	5.4	-1.5	5.9	0.1	-1.2	-5.5	-4.1	1.9
Guilty feelings	8.0	12.1	30.0	4.9	-0.0	5.5	0.1	-1.7	-4.7	-3.6	1.9
Wears glasses or contact lenses	0.3	0.4	1.1	0.1	-0.8	1.0	0.5	0.1	-0.2	-0.5	0.9
Ever taken oral contraceptive pill	0.9	1.0	3.9	0.6	0.9	1.2	-0.7	-2.0	-0.9	-0.3	-0.5
Hearing aid user	0.4	0.4	1.1	0.2	0.7	-0.2	-0.6	-0.2	-1.1	-1.0	-0.4
Mother’s age at death	2.2	2.8	9.1	3.0	-0.8	1.7	1.4	0.6	-1.0	-1.1	2.3
Financial situation satisfaction	1.0	1.2	2.4	-1.4	-0.4	-1.3	0.6	-0.4	1.3	1.5	-1.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.1	0.4	0.2	0.9	-1.2	0.2	-0.3	-1.3	-1.5
Commuting to job workplace: Public transport	2.5	3.0	5.7	2.4	-2.3	1.5	1.2	2.1	-1.2	-1.8	0.8
Eye problems/disorders: Glaucoma	2.0	2.3	6.1	-2.5	0.5	-0.9	0.4	0.7	2.1	2.4	-0.5
Medication: Blood pressure	7.6	14.5	39.3	-4.6	0.7	-4.8	3.2	2.3	4.1	6.3	-0.5
Pain type(s) experienced in last month: Hip pain	1.6	2.1	5.7	-1.2	-1.0	-2.4	-0.4	1.3	1.6	1.7	-0.9
Supplements: Fish oil (including cod liver oil)	3.3	4.3	15.9	-2.3	0.6	-2.6	1.1	-0.1	2.2	4.0	-0.6
High cholesterol (Self-reported)	0.2	0.3	1.9	-0.6	0.1	-0.5	0.0	-0.2	-0.4	1.4	-0.1
Medication: Bendroflumethiazide	6.7	10.2	25.8	-5.1	1.5	-4.0	0.8	1.6	3.5	4.3	-1.9
Medication: Paracetamol	0.9	1.4	3.0	1.6	-1.1	0.6	-1.4	-0.2	-1.7	-1.4	0.3
Medication: Lisinopril	1.5	2.0	5.0	-1.8	1.7	-2.2	0.2	-0.9	0.4	1.6	-0.9
Medication: Atorvastatin	0.1	0.2	0.8	-0.1	-0.3	0.0	0.3	-0.9	0.2	0.6	0.4
Illnesses of father: High blood pressure	1.8	2.2	6.9	-0.6	-0.0	-1.6	2.6	1.4	0.6	1.9	1.3
Alcohol drinker status: Never	0.6	0.8	2.6	0.8	-0.3	1.3	0.4	-0.5	-1.6	-0.5	0.6
Ever smoked	0.5	0.9	2.6	-0.7	0.9	-0.7	-1.4	0.5	0.1	0.6	-1.6
Basal metabolic rate	1.9	10.4	24.5	-5.0	0.8	-4.9	-0.1	1.6	3.7	3.6	-2.2
Leg fat percentage (left)	1.9	6.9	18.7	-3.2	1.2	-4.3	2.0	1.8	2.4	3.5	-0.1
Arm fat-free mass (left)	2.0	9.9	23.5	-4.8	0.3	-4.8	-0.0	2.1	3.4	3.2	-2.5
Number of operations (self-reported)	1.6	2.4	6.2	-1.9	0.8	-2.5	0.2	-0.7	1.2	2.5	-0.1
Average weekly beer plus cider intake	4.6	6.7	13.9	3.1	-2.3	3.7	-2.6	-2.2	-1.5	-3.0	1.4
Irritability	14.2	24.1	46.5	6.8	-3.0	6.2	-3.2	-3.2	-5.7	-6.6	1.3
Risk taking	3.0	4.4	10.5	-3.2	1.4	-3.2	0.5	1.3	2.3	2.2	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.0	0.0	0.6	0.3	-0.5	-0.0	-1.4	-0.9	0.8
Fractured/broken bones in last 5 years	1.6	2.0	7.8	0.9	-0.6	1.0	-2.2	-2.8	-0.5	-1.2	0.2
Age started oral contraceptive pill	1.4	1.8	5.3	2.3	-0.3	1.5	-0.4	-0.1	-1.6	-1.9	0.0
Diastolic blood pressure, automated reading	5.6	17.4	39.0	-6.2	4.2	-5.9	0.9	0.4	2.8	5.6	-2.5
Ever depressed for a whole week	1.9	2.3	7.2	1.9	-0.2	1.7	-0.3	0.2	-2.7	-2.1	-0.5
Unable to work because of sickness or disability	1.5	2.0	4.0	-1.8	0.3	-2.0	-0.6	-0.2	1.3	2.0	-1.5
Commuting to job workplace: Cycle	0.6	0.7	2.3	-1.1	-1.5	-0.1	0.6	-0.2	1.2	0.5	0.6
Myopia	0.7	1.1	3.6	0.9	-1.9	1.7	0.1	0.1	0.2	-0.4	1.1
Vascular/heart problems diagnosed by doctor	4.9	13.3	29.4	4.9	-2.2	5.4	-2.4	-1.8	-3.5	-5.1	0.7
Cholesterol lowering medication	0.4	0.6	3.4	-0.8	-0.8	-0.1	0.3	0.2	-1.9	0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.7	-0.2	-1.6	-0.4	0.6	0.9	-0.3	1.0	0.7
Pain experienced in last month	0.3	0.5	2.5	0.0	-0.0	1.6	0.6	-0.4	0.1	-0.4	1.0
Supplements: Calcium	0.9	0.9	2.3	0.5	0.4	1.3	0.4	-0.6	-1.5	-0.7	1.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.7	0.4	0.3	-0.4	0.9	0.3	0.5	0.0	1.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	0.7	0.4	0.6	0.0	0.8	-0.8	0.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	2.5	3.3	10.1	-1.2	-0.4	-2.3	1.0	1.6	3.2	2.3	-0.5
Heart disease (siblings)	1.5	1.8	7.3	0.0	1.4	0.8	1.3	-1.5	-0.6	-0.6	2.7
Alcohol drinker status: Previous	0.1	0.2	0.7	-0.8	0.1	-0.3	-0.1	-0.2	-0.4	-0.4	0.5
Pack years of smoking	1.9	2.8	5.7	-1.2	0.8	-2.4	0.6	2.0	1.3	2.3	-1.7
Impedance of whole body	6.8	34.7	93.9	9.7	-1.9	9.1	-0.1	-2.3	-6.7	-6.1	3.3
Leg fat mass (left)	2.7	10.7	29.4	-4.4	1.2	-5.4	1.3	1.8	3.4	4.1	-1.0
Arm predicted mass (left)	2.0	10.3	24.8	-5.0	0.4	-4.9	-0.3	1.7	3.4	3.4	-2.7