Best TWAS P=7.25e-14 · Best GWAS P=4.47e-15 conditioned to 0.0181
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | CYP17A1-AS1 | 0.14 | 0.01 | lasso | 11 | 0.00 | 4.7e-01 | -6.8 | -5.2 | 2.3e-07 | 0.87 | 0.03 | 0.59 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SUFU | 0.07 | 0.04 | lasso | 3 | 0.04 | 3.5e-04 | -6.8 | -6.6 | 3.4e-11 | 0.83 | 0.37 | 0.18 | FALSE |
| 3 | GTEx | Testis | NT5C2 | 0.20 | 0.03 | lasso | 8 | 0.08 | 2.8e-04 | -6.8 | -7.1 | 1.2e-12 | 0.86 | 0.05 | 0.90 | FALSE |
| 4 | GTEx | Testis | CYP17A1-AS1 | 0.14 | 0.08 | enet | 5 | 0.10 | 2.3e-05 | -6.8 | 6.9 | 6.3e-12 | -0.97 | 0.05 | 0.93 | FALSE |
| 5 | GTEx | Thyroid | WBP1L | 0.26 | 0.10 | enet | 9 | 0.13 | 2.1e-10 | -4.2 | 6.1 | 1.1e-09 | -0.80 | 0.62 | 0.38 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | CNNM2 | 0.11 | 0.08 | lasso | 3 | 0.07 | 2.2e-09 | -7.2 | -7.2 | 5.6e-13 | 0.99 | 0.02 | 0.98 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | USMG5 | 0.04 | 0.03 | lasso | 9 | 0.03 | 1.6e-04 | -3.1 | 5.5 | 4.4e-08 | -0.64 | 0.04 | 0.94 | FALSE |
| 8 | YFS | Blood | NT5C2 | 0.13 | 0.10 | bslmm | 382 | 0.11 | 7.3e-35 | -7.8 | -7.5 | 7.2e-14 | 0.94 | 0.01 | 0.99 | TRUE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | SFXN2 | 0.11 | 0.05 | blup | 47 | 0.05 | 7.2e-04 | -4.4 | 5.2 | 2.1e-07 | -0.63 | 0.15 | 0.55 | FALSE |
| 10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | AS3MT | 0.05 | 0.02 | blup | 62 | 0.03 | 2.1e-03 | 3.2 | -6.3 | 3.9e-10 | 0.72 | 0.02 | 0.32 | FALSE |