TWAS hub - HIPK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1278	0.0537	0.00650	-0.003	NA	0.005	NA	-0.002	0.80	NA	0.1300	NA	0.50
2	GTEx	Muscle Skeletal	0.0701	0.0298	0.00098	0.000	NA	0.016	NA	0.003	0.35	NA	0.0095	NA	0.14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Rheumatoid Arthritis	38.9	53.5	61.0	6.8	-7.8
Hypothyroidism (self reported)	28.3	65.0	72.4	8.5	-7.6
Hypothyroidism/myxoedema (self-reported)	19.4	37.9	49.8	7.1	-5.1
Medication: Levothyroxine sodium	16.5	28.0	34.3	5.9	-4.7
Taking other prescription medications	7.4	11.3	16.7	4.1	-2.4
Crohns Disease (2012)	6.3	10.1	20.2	-4.5	0.1
Other serious medical condition/disability diagnosed by doctor	6.0	7.8	10.4	2.3	-3.2
Long-standing illness, disability or infirmity	5.7	8.7	8.9	3.0	-2.9
Emphysema/chronic bronchitis	5.5	6.2	12.3	3.5	-0.4
Serious illness, injury or assault to yourself	5.3	6.4	12.3	3.5	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.0	5.9	11.3	3.4	0.7
Crohns Disease (2017)	4.7	10.4	19.4	-4.4	1.2
Number of treatments/medications taken	4.4	8.0	13.8	3.7	-1.5
Bipolar Disorder (2011)	4.1	4.0	6.2	2.5	-1.3
Illnesses of father: High blood pressure	3.6	4.5	6.1	-2.5	-1.7
Medication: Omeprazole (e.g. Zanprol)	3.6	4.3	8.7	2.9	0.1
Number of incorrect matches in round	3.1	5.2	6.0	2.1	-2.5
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	6.3	0.1	-2.5
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	6.4	2.5	0.3
Mother’s age at death	2.9	3.6	6.2	-2.5	1.0
Alcohol drinker status: Previous	2.9	3.3	5.1	2.3	-1.2
Bipolar Disorder (2018)	2.8	4.4	4.5	2.1	-2.1
Depression (self-reported)	2.8	3.4	4.8	1.4	-2.2
Hearing aid user	2.8	3.2	5.7	2.4	0.9
Hayfever, allergic rhinitis or eczema	2.7	5.9	6.4	-2.3	2.5
Commuting to job workplace: Walk	2.7	3.0	3.6	-1.9	-1.5
Myopia	2.7	3.9	7.1	0.9	-2.7
Financial difficulties in last 2 years	2.6	3.5	5.1	2.3	-1.4
Medication: Cholesterol lowering	2.6	4.0	4.6	2.1	-1.8
Medication for cholesterol, blood pressure or diabetes	2.6	4.4	6.0	-1.7	2.4
Heart attack	2.5	3.2	6.0	2.5	-0.6
Number of live births	2.5	3.6	6.5	0.8	2.5
Medication: Omeprazole	2.4	2.8	5.6	2.4	0.2
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	5.8	-2.4	0.1
Supplements: Calcium	2.4	2.7	3.8	1.9	-1.2
Heart attack/myocardial infarction (self-reported)	2.4	3.1	5.4	2.3	-0.9
Major Depression (MDD)	2.3	2.8	2.9	1.7	-1.7
Reaction Time	2.3	4.4	7.2	-2.7	1.3
Qualifications: None of the above	2.3	5.0	7.4	2.7	1.6
Unable to work because of sickness or disability	2.3	2.9	4.6	1.1	-2.1
Ever had hysterectomy (womb removed)	2.2	2.4	3.7	-1.1	1.9
Severe depression (siblings)	2.2	2.5	4.5	0.6	-2.1
Birth weight	2.2	4.9	6.9	-2.6	1.7
Overall health rating	2.2	4.6	6.1	2.5	-1.8
Age started oral contraceptive pill	2.2	2.7	5.1	0.6	2.3
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	4.3	-2.1	1.1
Qualifications: A levels/AS levels or equivalent	2.1	4.6	9.1	-3.0	-0.2
Qualifications: College or University degree	2.1	6.5	11.4	-3.4	-1.2
Number of full sisters	2.1	2.5	3.1	1.8	-1.4
Alcohol drinker status: Never	2.1	2.5	3.0	-1.7	-1.4
Birth weight of first child	2.0	3.7	4.0	-1.8	2.0
Worry too long after embarrassment	2.0	3.4	4.6	-1.4	2.2
Commuting to job workplace: Car/motor vehicle	2.0	2.3	4.3	0.5	2.1
Bipolar Disorder or Schizophrenia	1.9	4.7	5.5	2.4	-2.0
Alcohol intake frequency.	1.9	4.5	7.0	2.6	-1.4
Ever had prostate specific antigen (PSA) test	1.9	2.2	4.3	2.1	-0.3
Allergy or Eczema	1.8	4.8	6.7	-1.7	2.6
Respiratory disease	1.8	4.1	7.4	2.7	-0.9
Age when periods started (menarche)	1.8	4.2	7.8	-0.8	2.8
Mean time to correctly identify matches	1.8	3.4	4.3	-2.1	1.6
Ever taken oral contraceptive pill	1.8	2.0	3.6	1.9	0.6
Body Mass Index (BMI) (2010)	1.7	2.4	2.5	-1.6	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	4.0	0.2	-2.0
Pulse rate, automated reading	1.7	5.5	6.4	2.1	2.5
Illnesses of siblings: Diabetes	1.7	2.1	2.7	1.2	1.6
Number of self-reported non-cancer illnesses	1.7	2.9	5.6	2.4	-0.4
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.0	2.0	-0.1
Basal cell carcinoma (self-reported)	1.7	2.1	3.2	-1.8	1.0
Townsend deprivation index at recruitment	1.6	2.3	3.3	1.8	-1.1
Medication: Atenolol	1.6	2.0	3.7	0.5	-1.9
Cholesterol lowering medication	1.6	2.4	4.5	0.5	2.1
Heart disease (siblings)	1.6	1.9	2.7	1.6	-1.1
Irritable Bowel Disease (IBD)	1.5	3.6	7.1	-2.7	-0.1
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.4	1.8	-0.7
Medication: Paracetamol	1.5	2.4	4.5	2.1	0.6
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.1	-1.3	-1.5
Age at last live birth	1.5	2.2	3.3	-1.8	1.0
Supplements: Vitamin C	1.5	1.8	2.5	-1.6	-1.0
Risk taking	1.5	2.1	3.1	1.1	-1.8
Lupus	1.4	2.1	2.2	1.5	-1.4
Hearing difficulty/problems: Yes	1.4	2.2	4.0	0.5	-2.0
Age at first live birth	1.4	2.6	3.9	-2.0	1.1
Medication: Blood pressure	1.4	2.5	4.0	1.0	-2.0
Depression (Nagel 2018)	1.3	1.9	2.8	1.7	-1.0
Average weekly fortified wine intake	1.3	1.5	1.5	-1.2	1.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	2.0	1.1	-1.4
Hair/balding pattern: Pattern 4	1.3	3.1	5.6	2.4	-0.7
Headache pain in last month	1.3	2.2	4.3	0.3	-2.1
Medication: Paracetamol	1.3	2.0	3.1	1.8	1.0
Fasting Glucose	1.2	1.4	2.6	-1.6	0.5
Diabetes (father)	1.2	1.5	1.5	1.2	-1.2
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.3	-0.7	1.5
Qualifications: CSEs or equivalent	1.2	1.6	1.9	1.4	-1.2
Lung cancer (father)	1.2	1.4	2.6	-1.6	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	1.8	-1.3	-1.1
Guilty feelings	1.2	1.8	2.3	1.5	-1.2
Commuting to job workplace: Public transport	1.2	1.4	2.2	-0.8	-1.5
Coronary Artery Disease (CAD)	1.1	1.3	1.5	1.1	-1.2
Type 2 Diabetes (T2D) (2012)	1.1	1.2	1.3	-1.1	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	5.1	2.2	0.1
Mouth/teeth dental problems	1.1	1.7	2.0	-1.2	1.4
Allergy	1.1	2.5	4.4	0.8	-2.1
Medication: Simvastatin	1.1	1.6	2.5	1.6	0.8
Noisy workplace	1.1	1.4	1.4	1.2	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.4	1.6	-0.3
Leg fat percentage (right)	1.1	3.9	5.6	1.5	2.4
Shortness of breath walking on level ground	1.1	1.3	2.6	1.6	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	2.6	-1.6	0.4
Chest pain or discomfort	1.1	1.5	2.9	0.4	-1.7
Family relationship satisfaction	1.1	1.3	2.6	-1.6	-0.3
Qualifications: nursing, teaching	1.1	1.8	3.1	-1.8	-0.7
Miserableness	1.1	1.9	3.0	0.8	-1.7
High blood pressure (mother)	1.0	1.5	2.9	0.1	-1.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.1	1.0	-1.4
Alcohol intake versus 10 years previously	1.0	1.5	1.6	1.2	1.3
Comparative body size at age 10	1.0	2.9	4.5	-1.1	-2.1
Eye problems/disorders: None of the above	1.0	1.1	1.3	-1.0	-1.1
Medication for pain relief, constipation, heartburn	1.0	1.7	3.3	-1.8	-0.3
Wears glasses or contact lenses	1.0	1.2	2.3	-0.1	-1.5
Eye problems/disorders: Glaucoma	1.0	1.2	2.2	1.5	0.5
Leg fat percentage (left)	1.0	3.6	4.2	1.7	2.1
Commuting to job workplace: Cycle	1.0	1.2	2.0	-1.4	0.6
Schizophrenia (2018)	0.9	2.0	2.7	1.6	-1.1
Alzheimer’s Disease (in mother)	0.9	1.1	1.4	1.2	-0.9
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.6	-1.9	-0.8
HbA1C	0.9	1.0	1.5	1.2	-0.8
Pulse wave Arterial Stiffness index	0.9	1.0	2.1	-1.4	-0.1
Body fat percentage	0.9	3.6	4.6	1.6	2.1
Arm fat percentage (left)	0.9	3.5	5.7	1.2	2.4
Handedness (chirality/laterality): Left-handed	0.9	1.0	1.4	0.8	-1.2
Medication: Blood pressure	0.9	1.7	2.1	-1.2	1.4
Ulcerative Colitis (UC)	0.8	1.4	2.6	-0.6	-1.6
Ulcerative Colitis	0.8	1.1	2.2	-0.2	-1.5
Blood White Count	0.8	6.3	8.2	-2.1	2.9
Chronotype (morning person)	0.8	1.8	1.9	-1.3	-1.4
Hand grip strength (left)	0.8	2.1	4.0	-2.0	-0.4
Hearing difficulty/problems with background noise	0.8	1.3	1.9	-0.8	-1.4
Had other major operations	0.8	1.0	1.8	-0.5	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	1.3	1.1	-1.1
Exposure to tobacco smoke at home	0.8	0.9	1.7	1.3	-0.1
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.9	1.4	0.1
High blood pressure (siblings)	0.8	1.1	1.5	-0.8	1.2
Medication: Seretide 50 evohaler	0.8	0.9	1.3	0.7	1.1
Leg fat mass (right)	0.8	3.3	5.7	0.9	2.4
Medication: Aspirin	0.8	1.0	1.7	1.3	-0.6
Mood swings	0.8	1.4	2.0	1.4	-0.9
Medication: Aspirin	0.8	1.0	1.2	0.9	-1.1
Average weekly champagne plus white wine intake	0.8	1.1	2.0	-1.4	0.4
Financial situation satisfaction	0.8	1.0	1.1	1.1	-0.9
Sensitivity / hurt feelings	0.7	1.1	2.2	0.0	1.5
Pack years adult smoking proportion	0.7	1.1	1.2	1.0	-1.1
Trunk fat percentage	0.7	2.6	3.4	1.3	1.9
Maternal smoking around birth	0.7	1.0	2.0	1.4	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	3.1	1.8	0.5
Worrier / anxious feelings	0.7	1.3	2.3	0.6	1.5
Falls in the last year	0.7	1.0	1.9	1.4	-0.3
Whole body fat mass	0.7	2.9	5.6	0.5	2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.2	1.1	-0.6
Average weekly beer plus cider intake	0.7	1.0	1.7	-1.3	-0.6
Ever depressed for a whole week	0.7	0.8	1.5	1.2	-0.5
Pain experienced in last month	0.7	1.1	1.7	-0.8	-1.3
Leg fat mass (left)	0.7	2.8	4.8	0.9	2.2
Alzheimer’s Disease (including proxy)	0.6	0.9	1.4	1.2	-0.6
Systolic blood pressure, automated reading	0.6	1.9	3.6	-1.9	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	1.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	0.2	-1.2
Trunk fat mass	0.6	2.5	4.2	0.9	2.1
Had menopause	0.6	0.8	1.5	0.2	1.2
Illnesses of mother	0.6	0.8	1.4	-0.3	1.2
Number of children fathered	0.6	0.7	0.8	0.9	-0.8
Pulse wave peak to peak time	0.6	0.7	1.5	1.2	0.1
Migraine (self-reported)	0.6	0.7	0.9	-1.0	-0.7
Arm fat mass (left)	0.6	2.3	4.6	0.2	2.1
Ever smoked	0.6	1.1	2.1	-0.2	-1.4
Mean Putamen Volume	0.5	0.6	0.6	-0.7	-0.8
Heel T-Score	0.5	4.2	8.0	2.8	0.6
Smoking Status	0.5	1.2	2.1	0.5	-1.4
Medication: Metformin	0.5	0.7	1.3	1.1	0.4
Fed-up feelings	0.5	0.8	1.5	0.4	1.2
Stomach or abdominal pain in last month	0.5	0.6	1.2	1.1	0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	0.8	-0.9	-0.7
Arm fat percentage (right)	0.5	2.1	3.5	0.8	1.9
Hip circumference	0.5	2.2	3.5	1.0	1.9
Father’s age at death	0.5	0.6	1.0	-1.0	0.4
Hair/balding pattern: Pattern 3	0.5	0.7	1.4	-1.2	-0.1
Happiness	0.5	0.6	0.9	1.0	0.6
Length of working week for main job	0.5	0.5	0.7	-0.6	0.8
Loud music exposure frequency	0.5	0.6	0.8	0.9	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	-0.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.1	-1.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.5	-0.1	-1.2
Diastolic blood pressure, automated reading	0.5	1.5	2.3	-0.9	1.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.2	-1.5	-0.1
Alzheimer’s Disease (in father)	0.4	0.4	0.5	0.7	0.6
HDL Cholesterol	0.4	0.6	1.2	1.1	-0.1
Systolic Blood Pressure	0.4	2.2	3.8	-2.0	-0.7
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.6	0.7	-0.8
Relative age of first facial hair	0.4	0.9	0.9	-1.0	0.9
Vitamin and mineral supplements	0.4	0.6	1.1	-0.3	-1.0
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	0.2	1.0
Trunk fat-free mass	0.4	2.1	3.9	-2.0	0.5
Arm fat mass (right)	0.4	1.7	3.4	-0.0	1.9
Trunk predicted mass	0.4	2.1	3.9	-2.0	0.5
Pulse wave reflection index	0.4	0.5	0.6	-0.8	-0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.6	0.8	0.6
Glaucoma (self-reported)	0.4	0.5	0.9	0.9	0.2
Gout (self-reported)	0.4	0.5	0.7	-0.6	0.8
Arm fat-free mass (right)	0.4	1.8	2.3	-1.2	1.5
Medication: Allopurinol	0.4	0.5	0.8	0.4	0.9
Arm predicted mass (right)	0.4	2.1	2.4	-1.4	1.5
Comparative height size at age 10	0.4	2.2	2.2	-1.5	-1.5
Had major operations	0.4	0.4	0.7	-0.8	-0.4
Knee pain experienced in last month	0.4	0.6	0.9	0.9	-0.5
Average weekly red wine intake	0.4	0.5	1.0	-0.3	-1.0
Loneliness, isolation	0.4	0.5	0.8	0.5	-0.9
Ever had bowel cancer screening	0.4	0.5	0.9	1.0	-0.3
Osteoarthritis (self-reported)	0.4	0.5	0.9	-0.3	0.9
High cholesterol (Self-reported)	0.4	0.6	1.1	1.0	0.5
Pack years of smoking	0.4	0.7	0.7	0.9	-0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.8	-0.3
Age at First Birth	0.3	0.5	0.7	-0.8	0.5
Primary Biliary Cirrhosis	0.3	0.4	0.6	-0.8	-0.6
Schizophrenia (2014)	0.3	0.6	1.1	1.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	0.0	0.9
Diabetes (mother)	0.3	0.4	0.9	-0.9	-0.1
Body mass index (BMI)	0.3	1.3	2.3	0.5	1.5
Waist circumference	0.3	1.1	2.1	0.4	1.5
Fluid intelligence score	0.3	0.7	1.2	-1.1	-0.4
Illnesses of siblings	0.3	0.4	0.8	-0.2	-0.9
Weight	0.3	1.4	2.8	-0.3	1.7
Medication: Lansoprazole	0.3	0.3	0.5	0.7	0.5
Peak expiratory flow (PEF)	0.3	0.7	1.4	0.0	1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	-1.0	-0.3
Blood clot in the leg (DVT)	0.3	0.4	0.5	0.7	0.6
Medication: Amlodipine	0.3	0.5	0.6	0.6	-0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.8	-0.3
Number of full brothers	0.3	0.4	0.5	0.7	-0.5
Neck or shoulder pain in last month	0.3	0.5	0.7	0.8	-0.5
Medication: Ibuprofen	0.3	0.4	0.7	0.8	0.2
Suffer from ‘nerves’	0.3	0.4	0.8	-0.9	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	0.2	-0.8
Friendships satisfaction	0.3	0.4	0.6	-0.8	0.3
Mineral and other dietary supplements	0.3	0.4	0.7	-0.8	0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	0.4	0.7
Whole body water mass	0.3	1.4	2.5	-1.6	0.6
Arm fat-free mass (left)	0.3	1.4	2.3	-1.5	0.7
Irritability	0.3	0.5	1.0	1.0	-0.1
Arm predicted mass (left)	0.3	1.3	2.1	-1.4	0.7
Breast Cancer	0.2	0.4	0.5	-0.5	0.7
Ovarian Cancer	0.2	0.2	0.4	-0.6	0.3
Prostate Cancer	0.2	0.2	0.4	0.6	-0.3
LDL Cholesterol	0.2	0.3	0.5	0.4	-0.7
Neuroticism (2016)	0.2	0.3	0.5	-0.7	0.3
Triglycerides	0.2	0.3	0.5	-0.4	0.7
Blood Platelet Count	0.2	2.6	4.8	2.2	0.6
BMI	0.2	1.3	2.5	1.6	0.4
Lung FEV1/FVC ratio	0.2	0.9	1.2	-1.1	0.7
Lung FVC	0.2	1.2	2.1	0.5	-1.5
Average weekly spirits intake	0.2	0.3	0.5	0.3	0.7
Supplements: Zinc	0.2	0.2	0.3	0.5	-0.5
Medication: Co-codamol	0.2	0.2	0.4	0.3	-0.6
Multivitamins +/- minerals	0.2	0.2	0.3	0.4	0.6
Alcohol usually taken with meals	0.2	0.4	0.8	0.9	-0.2
Pain all over the body in last month	0.2	0.2	0.3	-0.1	-0.6
Diabetes (self-reported)	0.2	0.3	0.5	0.7	-0.3
Medication: Ramipril	0.2	0.3	0.4	0.3	0.7
Pulse rate	0.2	0.4	0.7	-0.3	0.8
Breastfed as a baby	0.2	0.3	0.4	0.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.7	0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.1	-0.7
Illnesses of father: Heart disease	0.2	0.3	0.6	0.8	-0.2
Whole body fat-free mass	0.2	1.4	2.5	-1.6	0.6
Diabetes diagnosed by doctor	0.2	0.4	0.7	0.8	-0.3
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.3	0.6
Medication: Gliclazide	0.2	0.2	0.4	0.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	-0.6	-0.2
Basal metabolic rate	0.2	1.2	1.7	-1.3	0.8
Number of operations (self-reported)	0.2	0.3	0.4	0.4	0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	0.3	0.6
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	0.5	-0.6
Worry (Nagel 2018)	0.1	0.2	0.2	-0.4	0.5
Blood Red Count	0.1	1.0	1.9	-1.4	0.1
Waist Hip Ratio (WHR)	0.1	0.4	0.4	-0.6	-0.6
Cardiovascular Disease	0.1	0.2	0.3	0.2	-0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	0.5	-0.1
Neuroticism	0.1	0.2	0.4	0.1	0.6
Hair Pigment	0.1	2.4	4.8	0.2	-2.2
Angina	0.1	0.2	0.3	0.5	0.2
Impedance of leg (right)	0.1	0.3	0.3	0.5	0.6
Leg fat-free mass (left)	0.1	0.7	0.8	-0.9	0.8
Hand grip strength (right)	0.1	0.3	0.3	-0.6	-0.4
High blood pressure	0.1	0.2	0.4	-0.6	0.3
Sitting height	0.1	1.1	1.7	-1.3	-0.6
Impedance of leg (left)	0.1	0.4	0.6	0.8	0.3
Leg predicted mass (left)	0.1	0.6	0.7	-0.9	0.7
Past tobacco smoking	0.1	0.2	0.4	-0.3	0.6
Nervous feelings	0.1	0.2	0.3	-0.5	-0.5
Neuroticism score	0.1	0.1	0.3	0.1	0.5
Time employed in main current job	0.1	0.1	0.2	0.2	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	0.5	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.2	0.4
Prospective memory result	0.1	0.1	0.1	0.2	0.3
Impedance of arm (left)	0.1	0.5	0.8	0.9	0.4
Standing height	0.1	1.4	2.5	-1.6	0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.2	0.5	-0.4
Health satisfaction	0.1	0.2	0.3	0.6	-0.0
Heart disease (mother)	0.1	0.1	0.3	0.5	-0.1
Leg pain on walking	0.1	0.2	0.3	-0.2	-0.5
Hypertension (Self-reported)	0.1	0.4	0.5	-0.7	0.5
Smoking status: Previous	0.1	0.1	0.2	0.4	-0.3
Leg fat-free mass (right)	0.1	0.4	0.6	-0.8	0.4
Medication for cholesterol	0.1	0.2	0.3	-0.5	-0.3
Asthma (self-reported)	0.1	0.1	0.2	0.4	-0.3
Smoking status: Current	0.1	0.1	0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.5	-0.4
Leg predicted mass (right)	0.1	0.3	0.5	-0.7	0.4
Medication: Lisinopril	0.1	0.1	0.1	-0.4	0.3
Medication: Atorvastatin	0.1	0.1	0.2	-0.1	-0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.5	0.3
Impedance of whole body	0.1	0.7	1.2	1.1	0.3
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.2	0.1
Blood Eosinophil Count	0.0	0.1	0.1	0.3	0.3
Height	0.0	0.9	1.1	-0.8	1.0
Tanning	0.0	0.3	0.4	-0.4	0.7
Medication for hormone replacement therapy	0.0	0.1	0.1	0.1	0.3
Current tobacco smoking	0.0	0.1	0.1	0.2	-0.3
Relative age voice broke	0.0	0.0	0.1	0.3	-0.1
Supplements: Glucosamine	0.0	0.0	0.0	0.2	-0.1
Forced vital capacity (FVC)	0.0	0.1	0.1	-0.2	-0.3
Impedance of arm (right)	0.0	0.1	0.1	0.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.0	0.1	0.2
Asthma	0.0	0.1	0.1	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	0.5	0.2
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	-0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	0.2	-0.3
Angina (self-reported)	0.0	0.1	0.1	0.1	0.3
Back pain experienced in last month	0.0	0.0	0.1	0.2	0.1
Breast cancer (self-reported)	0.0	0.0	0.1	0.3	0.1
Osteoporosis (self-reported)	0.0	0.0	0.0	-0.0	-0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.1	-0.2
Medication: Bendroflumethiazide	0.0	0.1	0.1	-0.3	0.1
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.1	0.3	0.0

Hub : Genes

HIPK1

Models

Trait associations