[Hub]/) : Traits : High cholesterol (Self-reported) :

chr19:18,533,642-20,451,172

Best TWAS P=1.08e-15 · Best GWAS P=3.59e-19 conditioned to 2.94e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GATAD2A 0.13 0.30 lasso 7 0.29 2.4e-35 -5.6 5.6 2.6e-08 -0.35 1.00 0.00 FALSE
2 GTEx Artery Tibial MAU2 0.07 0.05 lasso 4 0.05 1.3e-04 -5.8 -5.8 7.7e-09 0.38 0.45 0.23 FALSE
3 GTEx Cells Transformed fibroblasts ATP13A1 0.14 0.06 lasso 5 0.05 2.2e-04 -8.0 -8.0 1.1e-15 0.93 0.19 0.56 TRUE
4 GTEx Cells Transformed fibroblasts GATAD2A 0.07 0.00 lasso 4 0.00 8.1e-01 -5.7 -6.9 4.6e-12 0.72 0.07 0.31 FALSE
5 GTEx Muscle Skeletal MAU2 0.09 0.04 lasso 4 0.05 5.1e-06 -5.0 6.1 1.1e-09 -0.59 0.99 0.01 FALSE
6 GTEx Spleen ATP13A1 0.16 0.01 lasso 5 0.02 9.7e-02 -5.6 -6.4 1.6e-10 0.35 0.08 0.07 TRUE
7 GTEx Whole Blood TMEM161A 0.06 0.00 enet 2 0.00 1.4e-01 -5.7 5.7 1.5e-08 -0.39 0.19 0.09 FALSE
8 GTEx Whole Blood GATAD2A 0.06 0.02 lasso 9 0.03 1.7e-03 -6.0 -6.3 2.7e-10 0.63 0.36 0.53 FALSE
9 ROSMAP Brain Pre-frontal Cortex ATP13A1 0.10 0.07 lasso 5 0.06 1.3e-08 -5.9 6.0 1.8e-09 -0.78 0.14 0.85 FALSE
10 YFS Blood GATAD2A 0.09 0.14 blup 365 0.14 7.5e-44 -5.6 -5.3 1.5e-07 0.38 1.00 0.00 FALSE
11 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma GATAD2A 0.02 0.02 lasso 1 0.02 2.1e-03 -5.6 -5.6 1.8e-08 0.38 0.09 0.04 FALSE
12 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HAPLN4 0.05 0.07 lasso 2 0.06 1.1e-07 -6.0 -6.2 4.6e-10 0.48 0.99 0.01 FALSE
13 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TM6SF2 0.04 0.03 blup 35 0.03 2.5e-04 -5.4 -6.4 1.7e-10 0.76 0.22 0.44 FALSE
14 The Cancer Genome Atlas Brain Lower Grade Glioma KIAA0892 0.03 0.01 lasso 7 0.02 6.3e-03 -6.0 5.9 3.5e-09 -0.41 0.06 0.18 FALSE
15 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma GMIP 0.07 0.00 blup 43 0.02 2.3e-02 -6.2 -6.0 1.7e-09 0.49 0.02 0.39 FALSE
16 The Cancer Genome Atlas Prostate Adenocarcinoma GATAD2A 0.04 0.03 lasso 2 0.03 2.9e-04 -5.6 -5.9 3.1e-09 0.52 0.24 0.39 FALSE
17 The Cancer Genome Atlas Thyroid Carcinoma HAPLN4 0.08 0.06 blup 37 0.09 1.8e-09 -5.9 -5.7 1.0e-08 0.33 1.00 0.00 FALSE
18 The Cancer Genome Atlas Thyroid Carcinoma KIAA0892 0.04 0.04 blup 43 0.02 4.1e-03 -6.0 6.2 5.6e-10 -0.43 0.53 0.05 FALSE
19 The Cancer Genome Atlas Thyroid Carcinoma TM6SF2 0.05 0.04 blup 34 0.05 2.8e-05 -5.4 -5.8 5.2e-09 0.71 0.29 0.55 FALSE