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chr19:18,533,642-20,451,172

Best TWAS P=1.08e-15 · Best GWAS P=3.59e-19 conditioned to 2.94e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GATAD2A	0.13	0.30	lasso	7	0.29	2.4e-35	-5.6	5.6	2.6e-08	-0.35	1.00	0.00	FALSE
2	GTEx	Artery Tibial	MAU2	0.07	0.05	lasso	4	0.05	1.3e-04	-5.8	-5.8	7.7e-09	0.38	0.45	0.23	FALSE
3	GTEx	Cells Transformed fibroblasts	ATP13A1	0.14	0.06	lasso	5	0.05	2.2e-04	-8.0	-8.0	1.1e-15	0.93	0.19	0.56	TRUE
4	GTEx	Cells Transformed fibroblasts	GATAD2A	0.07	0.00	lasso	4	0.00	8.1e-01	-5.7	-6.9	4.6e-12	0.72	0.07	0.31	FALSE
5	GTEx	Muscle Skeletal	MAU2	0.09	0.04	lasso	4	0.05	5.1e-06	-5.0	6.1	1.1e-09	-0.59	0.99	0.01	FALSE
6	GTEx	Spleen	ATP13A1	0.16	0.01	lasso	5	0.02	9.7e-02	-5.6	-6.4	1.6e-10	0.35	0.08	0.07	TRUE
7	GTEx	Whole Blood	TMEM161A	0.06	0.00	enet	2	0.00	1.4e-01	-5.7	5.7	1.5e-08	-0.39	0.19	0.09	FALSE
8	GTEx	Whole Blood	GATAD2A	0.06	0.02	lasso	9	0.03	1.7e-03	-6.0	-6.3	2.7e-10	0.63	0.36	0.53	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	ATP13A1	0.10	0.07	lasso	5	0.06	1.3e-08	-5.9	6.0	1.8e-09	-0.78	0.14	0.85	FALSE
10	YFS	Blood	GATAD2A	0.09	0.14	blup	365	0.14	7.5e-44	-5.6	-5.3	1.5e-07	0.38	1.00	0.00	FALSE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GATAD2A	0.02	0.02	lasso	1	0.02	2.1e-03	-5.6	-5.6	1.8e-08	0.38	0.09	0.04	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAPLN4	0.05	0.07	lasso	2	0.06	1.1e-07	-6.0	-6.2	4.6e-10	0.48	0.99	0.01	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TM6SF2	0.04	0.03	blup	35	0.03	2.5e-04	-5.4	-6.4	1.7e-10	0.76	0.22	0.44	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA0892	0.03	0.01	lasso	7	0.02	6.3e-03	-6.0	5.9	3.5e-09	-0.41	0.06	0.18	FALSE
15	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMIP	0.07	0.00	blup	43	0.02	2.3e-02	-6.2	-6.0	1.7e-09	0.49	0.02	0.39	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	GATAD2A	0.04	0.03	lasso	2	0.03	2.9e-04	-5.6	-5.9	3.1e-09	0.52	0.24	0.39	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	HAPLN4	0.08	0.06	blup	37	0.09	1.8e-09	-5.9	-5.7	1.0e-08	0.33	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA0892	0.04	0.04	blup	43	0.02	4.1e-03	-6.0	6.2	5.6e-10	-0.43	0.53	0.05	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	TM6SF2	0.05	0.04	blup	34	0.05	2.8e-05	-5.4	-5.8	5.2e-09	0.71	0.29	0.55	FALSE