Hub : Genes

SLC35D2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0278	0.0119	0.0021	0.006	0.005	0.010	0.013	0.008	0.0044	0.0072	0.00021	2.6e-05	0.0012
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0383	0.0213	0.0054	-0.001	0.020	0.019	NA	-0.001	0.5400	0.0023	0.00270	NA	0.4000
3	TCGA	Testicular Germ Cell Tumors	0.1760	0.0840	0.0029	0.036	0.070	0.059	NA	0.050	0.0200	0.0018	0.00390	NA	0.0075

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	1.3	1.1	-0.3	0.7
Bipolar Disorder or Schizophrenia	0.2	0.5	0.6	0.6	-0.8	0.6
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	-0.8	0.0	-0.5
Depression (Nagel 2018)	0.1	0.1	0.2	-0.2	-0.3	-0.4
Intelligence (Savage-Jansen 2018)	1.7	5.1	10.2	-0.2	3.2	-2.2
Neuroticism (Nagel 2018)	0.1	0.3	0.4	-0.5	0.7	-0.5
Schizophrenia (2018)	0.1	0.2	0.7	-0.0	-0.8	0.2
Schizophrenia vs Biploar Disorder	1.3	1.7	2.6	-0.1	-1.6	1.6
Worry (Nagel 2018)	0.3	0.5	0.7	-0.7	0.8	-0.7
Alzheimer’s Disease (in mother)	2.2	2.6	4.0	-0.5	2.0	-1.9
Alzheimer’s Disease (in father)	0.1	0.1	0.4	-0.1	0.6	0.0
Alzheimer’s Disease (including proxy)	1.2	1.7	2.4	-0.9	1.6	-1.4
Crohns Disease (2017)	0.0	0.1	0.1	0.4	0.2	-0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	0.1	-0.3	-0.8
Ulcerative Colitis (UC)	0.2	0.4	0.9	-0.2	-0.4	-0.9
Major Depression (MDD)	0.6	0.7	1.1	-0.1	-1.0	1.0
Reaction Time	0.1	0.3	0.7	0.1	-0.8	-0.3
Verbal and Numeric Reasoning (VNR)	1.0	2.4	3.7	-1.0	1.6	-1.9
Breast Cancer	0.1	0.2	0.4	-0.5	-0.1	0.6
Ovarian Cancer	0.1	0.2	0.3	-0.2	-0.3	0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	4.9	7.1	11.8	-2.0	2.4	-3.4
Bipolar Disorder (2011)	2.5	2.4	5.2	1.3	2.3	-0.6
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	-0.3	-0.8	-0.4
Coronary Artery Disease (CAD)	0.2	0.3	0.7	-0.2	-0.9	-0.1
Crohns Disease (2012)	0.2	0.2	0.4	0.7	0.6	0.0
Mean Putamen Volume	1.8	2.1	3.5	-1.9	-1.3	-1.0
Fasting Glucose	1.9	2.3	4.7	-1.5	-2.2	0.3
HbA1C	0.1	0.1	0.1	0.4	0.0	-0.2
HDL Cholesterol	0.1	0.1	0.2	0.3	-0.4	-0.2
LDL Cholesterol	1.3	2.0	3.0	1.7	1.2	1.4
Lupus	2.6	4.0	8.4	-1.9	0.0	-2.9
Neuroticism (2016)	0.1	0.1	0.2	0.5	0.1	-0.2
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.3	-0.4	0.4
Rheumatoid Arthritis	1.2	1.6	3.1	-1.8	-0.4	-1.2
Schizophrenia (2014)	0.1	0.1	0.2	0.4	0.2	0.4
Triglycerides	0.1	0.1	0.2	-0.4	-0.0	-0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.2	-0.3	0.2
Ulcerative Colitis	0.4	0.5	1.1	-0.8	-1.0	-0.0
Blood Eosinophil Count	0.3	2.3	3.7	1.9	-1.2	1.3
Blood Platelet Count	2.1	24.8	33.8	4.5	-4.5	5.8
Blood Red Count	0.3	3.0	4.4	1.7	2.1	1.3
Blood White Count	0.6	4.2	7.7	2.8	-1.1	1.9
Heel T-Score	0.1	0.6	1.0	1.0	0.4	0.7
BMI	0.6	3.6	9.2	-0.8	-3.0	1.0
Height	6.0	115.1	196.0	-9.6	7.6	-14.0
Waist Hip Ratio (WHR)	0.5	2.0	3.0	1.6	1.7	0.7
Systolic Blood Pressure	0.3	1.7	2.4	1.6	1.4	0.8
Smoking Status	0.3	0.8	1.9	0.7	0.1	-1.4
Allergy or Eczema	0.5	1.3	3.5	-0.7	-1.9	0.1
Cardiovascular Disease	0.3	0.9	2.3	-1.5	0.6	-0.3
Hypothyroidism (self reported)	2.6	5.9	13.3	-2.1	0.1	-3.6
Respiratory disease	0.2	0.5	0.9	-0.8	-0.1	-0.9
Type 2 Diabetes (T2D) (2018)	2.2	4.1	10.3	0.7	-1.3	3.2
Lung FEV1/FVC ratio	0.2	0.9	1.4	0.8	-0.8	1.2
Lung FVC	0.1	0.3	0.8	0.3	0.9	-0.2
Neuroticism	0.5	1.1	1.4	-0.9	1.0	-1.2
Chronotype (morning person)	0.9	2.1	3.9	-0.7	-2.0	1.4
Hair Pigment	0.1	4.1	7.3	-2.7	-1.0	-2.0
Tanning	0.0	0.2	0.3	0.6	-0.2	-0.3
Hand grip strength (left)	0.2	0.6	1.3	0.5	1.1	-0.6
Number of treatments/medications taken	1.8	3.2	6.8	-2.6	-0.3	-1.7
Average weekly spirits intake	0.7	0.9	1.6	-1.3	-0.7	-0.8
Sensitivity / hurt feelings	0.2	0.3	0.5	0.6	0.7	0.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	0.3	0.7	-0.2
Hearing difficulty/problems: Yes	2.0	3.1	5.0	-2.2	-1.6	-1.2
Relative age of first facial hair	0.0	0.0	0.1	0.2	-0.1	-0.1
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.8	-2.0	0.0	-1.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	0.3	0.7	-0.3
Ever had hysterectomy (womb removed)	0.9	1.0	1.6	-1.1	0.2	-1.3
Systolic blood pressure, automated reading	0.1	0.4	0.7	0.9	0.3	0.6
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	4.2	-1.4	-2.0	0.6
Angina	0.1	0.2	0.3	-0.5	-0.3	-0.5
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.6	-0.5	-0.3
Vitamin and mineral supplements	1.1	1.5	2.6	1.6	1.2	0.7
Supplements: Zinc	1.7	1.9	2.6	-1.6	-0.7	-1.6
Medication: Co-codamol	1.9	2.3	3.4	-1.8	-0.4	-1.8
Medication: Metformin	1.9	2.7	6.4	0.5	-1.2	2.5
Diabetes (father)	0.1	0.1	0.2	-0.5	0.2	-0.0
Diabetes (mother)	0.2	0.2	0.3	-0.5	0.6	-0.2
Severe depression (siblings)	0.3	0.3	0.5	-0.5	-0.7	-0.2
Pack years adult smoking proportion	0.9	1.4	4.0	-0.3	-2.0	0.3
Impedance of leg (right)	1.1	5.3	9.8	1.5	-2.0	3.1
Leg fat-free mass (left)	2.0	10.5	19.1	-3.2	1.3	-4.4
Trunk fat percentage	1.7	6.7	14.9	-2.2	-3.9	0.8
Hand grip strength (right)	0.3	0.8	2.2	0.1	1.5	-0.6
Townsend deprivation index at recruitment	0.6	0.8	1.5	1.2	-0.4	0.8
Current tobacco smoking	0.3	0.5	0.9	0.9	-0.8	-0.3
Average weekly fortified wine intake	2.2	2.6	5.5	-2.3	-1.5	-0.3
Maternal smoking around birth	1.8	2.6	4.5	-1.8	-2.1	-0.4
Fed-up feelings	0.1	0.2	0.4	-0.6	-0.5	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	0.3	0.0	-0.3
Relative age voice broke	1.7	2.6	4.8	2.2	1.4	1.0
Taking other prescription medications	2.9	4.4	8.9	-3.0	0.1	-2.1
Age when periods started (menarche)	0.1	0.1	0.3	0.5	0.1	0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.1	-0.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.3	1.0	0.6	1.2
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.7	-1.6	0.3	-0.4
Qualifications: CSEs or equivalent	3.2	4.2	6.4	2.5	0.9	2.3
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-1.2	-0.3	-0.3
High blood pressure	0.8	2.2	4.6	-2.1	0.4	-1.4
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.4	-0.8	-2.1	0.2
Multivitamins +/- minerals	0.9	1.1	1.2	-1.0	-1.1	-1.0
Stomach or abdominal pain in last month	0.0	0.1	0.2	-0.4	0.0	-0.0
Supplements: Glucosamine	0.2	0.2	0.3	-0.4	-0.6	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.2	-0.6	-0.6
Medication: Atenolol	0.3	0.4	0.6	-0.3	0.6	-0.8
Medication: Levothyroxine sodium	4.6	7.8	13.0	-3.6	-0.8	-3.1
Sitting height	4.7	33.3	58.5	-4.5	4.6	-7.7
Chronic bronchitis/emphysema (father)	1.0	1.1	3.1	-1.8	-0.5	-0.2
High blood pressure (mother)	0.9	1.3	2.0	-0.1	-1.4	1.3
Body mass index (BMI)	0.8	3.3	7.6	-1.2	-2.8	0.9
Impedance of leg (left)	1.2	5.9	11.3	2.1	-1.3	3.4
Leg predicted mass (left)	1.9	10.2	18.9	-3.2	1.3	-4.4
Trunk fat mass	1.2	5.4	7.8	-2.8	-2.8	-0.7
Waist circumference	0.8	3.1	5.9	-2.4	-1.6	-0.9
Number of incorrect matches in round	0.6	1.0	1.9	-1.4	-0.7	-0.7
Past tobacco smoking	0.1	0.2	0.2	-0.3	-0.4	0.5
Alcohol usually taken with meals	0.3	0.5	0.8	-0.2	-0.9	0.7
Nervous feelings	0.2	0.4	0.9	-0.3	-0.9	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	4.5	-0.2	-2.1	1.9
Hearing difficulty/problems with background noise	1.8	2.9	4.7	-2.2	-1.1	-1.6
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	0.5	0.4	0.2
Had menopause	0.7	0.8	1.2	-1.0	1.1	-0.6
Had other major operations	1.0	1.2	2.4	-1.1	-1.5	-0.2
Forced vital capacity (FVC)	1.4	5.5	11.2	-0.1	3.3	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.3	1.5	0.5	1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.5	0.6	-0.3	0.7
Qualifications: None of the above	0.3	0.7	1.7	0.3	-1.3	0.5
Financial difficulties in last 2 years	1.1	1.5	3.5	1.9	0.7	0.7
Mouth/teeth dental problems	0.3	0.5	1.0	0.1	0.7	-1.0
Heart attack	3.8	4.9	8.1	-2.8	-2.1	-1.5
Allergy	0.7	1.6	3.5	1.1	1.9	0.0
Pain all over the body in last month	0.1	0.2	0.3	-0.6	-0.3	-0.2
Diabetes (self-reported)	2.8	4.3	8.2	0.5	-2.1	2.9
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	4.4	-0.7	1.0	-2.1
Medication: Ramipril	0.2	0.3	0.5	-0.7	-0.1	0.5
Medication: Simvastatin	0.2	0.3	0.8	-0.0	0.9	-0.1
Fluid intelligence score	0.4	0.9	1.5	-0.2	1.2	-1.1
Illnesses of siblings	0.4	0.6	1.4	-0.1	-1.2	0.6
Neuroticism score	0.3	0.6	0.8	-0.9	0.6	-0.8
Weight	1.3	6.2	10.1	-3.2	-0.3	-2.9
Impedance of arm (right)	0.1	0.5	1.1	0.0	-1.1	0.5
Arm fat percentage (right)	1.3	5.2	11.9	-1.5	-3.5	1.3
Trunk fat-free mass	2.5	14.4	24.3	-2.9	3.2	-4.9
Hip circumference	1.4	6.0	10.9	-3.3	-1.6	-2.1
Time employed in main current job	0.6	0.7	1.5	0.3	0.8	-1.2
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.1	-0.4	0.4
Father’s age at death	0.9	1.2	2.6	-0.2	0.9	-1.6
Worrier / anxious feelings	1.1	2.2	3.2	-0.8	1.6	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.1	-1.8	-0.7	-0.4
Falls in the last year	2.3	3.2	5.4	-1.9	-2.3	0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.5	0.8	-0.3
Number of live births	1.9	2.7	4.6	1.7	0.7	2.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	6.6	0.2	2.6	-1.2
Pulse rate	0.7	1.1	2.4	0.6	-0.8	1.5
Happiness	0.5	0.6	1.7	-0.2	0.3	-1.3
Noisy workplace	0.5	0.6	1.1	-0.1	-0.9	1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.3	0.9	1.5	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	3.5	-1.9	-0.7	-1.5
Mouth/teeth dental problems: Dentures	1.4	2.3	3.6	0.7	-1.7	1.9
Asthma	1.2	2.3	3.5	-1.9	0.2	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.7	-1.6	-0.7	-0.6
Medication: Cholesterol lowering	0.1	0.1	0.2	0.3	-0.5	0.4
Depression (self-reported)	0.1	0.1	0.1	-0.3	0.3	-0.3
Medication: Lansoprazole	0.2	0.2	0.4	-0.4	-0.7	0.1
Prospective memory result	0.3	0.3	0.6	-0.5	-0.8	0.4
Lung cancer (father)	0.6	0.7	1.8	0.5	1.4	0.1
Illnesses of mother	0.4	0.6	1.3	1.2	0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	5.7	-0.2	2.4	-1.7
Pulse wave Arterial Stiffness index	0.7	0.8	1.2	1.1	1.0	0.5
Impedance of arm (left)	0.0	0.2	0.5	-0.1	-0.7	-0.0
Arm fat mass (right)	1.0	4.2	6.1	-2.5	-2.5	-0.5
Trunk predicted mass	2.5	14.1	24.0	-2.9	3.1	-4.9
Standing height	4.0	39.2	71.4	-4.5	5.1	-8.4
Length of working week for main job	1.2	1.3	2.1	-1.4	-0.7	-1.2
Exposure to tobacco smoke at home	1.2	1.4	2.4	-1.3	-1.5	0.1
Breastfed as a baby	1.2	1.5	3.3	0.9	1.8	-0.7
Tense / ‘highly strung’	2.3	3.7	7.7	-2.8	-0.8	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	-0.5	0.3
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	0.8	1.3	-0.0
Birth weight of first child	0.3	0.5	0.9	0.8	-0.2	1.0
Peak expiratory flow (PEF)	0.2	0.5	1.2	-0.6	1.1	-0.2
Pulse wave reflection index	0.6	0.8	1.8	0.7	1.4	0.2
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.3	-1.5	-0.2	-0.8
Loud music exposure frequency	0.2	0.3	0.5	-0.2	-0.5	-0.7
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	6.3	2.5	0.4	1.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.8	-1.4	-0.3	-0.8
Blood clot in the leg (DVT)	0.5	0.6	0.9	-0.9	-1.0	0.5
Medication: Paracetamol	0.3	0.6	1.0	-1.0	-0.7	-0.4
Headache pain in last month	0.1	0.2	0.5	0.2	-0.2	0.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.4	1.0	0.1	1.2
Glaucoma (self-reported)	2.4	2.8	4.2	-2.1	-0.4	-2.0
Gout (self-reported)	0.8	1.1	1.8	0.8	-1.0	1.3
Hypothyroidism/myxoedema (self-reported)	3.6	7.0	11.3	-3.1	-0.4	-3.4
Medication: Amlodipine	2.3	3.2	4.9	-2.2	0.6	-2.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.5	-0.5	-0.7	0.7
Birth weight	1.1	2.3	5.8	-1.0	-0.2	-2.4
Chronic bronchitis/emphysema (mother)	3.1	3.6	5.0	-2.2	-1.0	-2.2
High blood pressure (siblings)	0.3	0.4	1.0	0.5	1.0	-0.2
Forced vital capacity (FVC), Best measure	1.7	6.3	10.4	-0.5	3.2	-2.9
Body fat percentage	1.9	7.4	17.1	-1.6	-4.1	1.6
Leg fat percentage (right)	2.9	10.4	20.9	-0.7	-4.6	3.1
Arm fat-free mass (right)	1.9	9.7	16.9	-2.8	2.1	-4.1
Exposure to tobacco smoke outside home	0.5	0.6	1.1	-1.0	-0.7	-0.5
Comparative body size at age 10	0.1	0.3	0.5	-0.6	-0.7	-0.1
Number of full brothers	0.2	0.2	0.3	-0.5	0.4	-0.5
Worry too long after embarrassment	1.3	2.2	5.2	-0.1	2.3	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.4	0.1	1.6	0.1
Wheeze or whistling in the chest in last year	0.4	0.8	1.9	-0.3	-1.4	-0.6
Number of children fathered	0.8	0.9	1.4	1.2	0.9	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.7	-0.0	-1.9	1.5
Age at first live birth	0.4	0.7	1.3	0.2	1.1	-0.9
Pulse wave peak to peak time	0.8	0.9	1.6	-1.3	-0.6	-0.9
Health satisfaction	0.6	0.8	0.9	-0.8	-1.0	-0.9
Shortness of breath walking on level ground	0.3	0.3	0.8	-0.9	-0.0	-0.4
Qualifications: College or University degree	0.8	2.5	5.9	-1.1	0.7	-2.4
Eye problems/disorders: None of the above	2.1	2.4	4.3	2.1	0.6	1.6
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.9	-1.1	-0.1	-1.4
Emphysema/chronic bronchitis	0.6	0.7	1.2	-0.8	-1.1	0.5
Medication for pain relief, constipation, heartburn	0.5	0.8	2.1	1.4	0.2	0.5
Neck or shoulder pain in last month	1.6	2.3	3.9	-2.0	-1.4	-1.0
Medication: Blood pressure	0.9	1.5	3.2	-1.8	-0.1	-1.2
Angina (self-reported)	0.1	0.1	0.1	-0.2	-0.4	-0.1
Migraine (self-reported)	0.3	0.4	0.7	0.5	-0.5	0.9
Medication: Ibuprofen	0.6	0.7	1.7	-1.3	-0.4	-0.5
Medication: Allopurinol	1.4	1.9	4.1	2.0	0.6	1.1
Medication: Omeprazole	0.4	0.5	1.4	0.2	-0.2	1.2
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.6	0.1	-0.2
Mean time to correctly identify matches	0.1	0.2	0.4	-0.4	-0.6	-0.3
Heart disease (mother)	0.3	0.4	1.1	-0.3	-0.0	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-0.3	1.0	-0.5
Whole body fat mass	1.2	4.8	8.9	-2.4	-3.0	-0.1
Leg fat mass (right)	1.3	5.2	11.8	-1.6	-3.4	1.0
Arm predicted mass (right)	1.6	8.4	14.4	-2.6	2.0	-3.8
Pulse rate, automated reading	2.4	7.8	11.4	1.2	-3.4	3.2
Alcohol intake frequency.	0.6	1.4	2.8	-1.0	-1.7	0.7
Comparative height size at age 10	2.6	14.2	25.3	-2.9	3.0	-5.0
Number of full sisters	1.4	1.7	2.5	1.6	1.6	-0.2
Suffer from ‘nerves’	0.0	0.0	0.0	0.1	0.2	-0.2
Overall health rating	1.7	3.7	7.4	-2.7	-0.9	-1.8
Chest pain or discomfort	2.9	4.2	7.9	-2.8	-0.4	-2.1
Had major operations	0.3	0.3	0.9	-0.9	-0.0	-0.4
Age at last live birth	1.5	2.2	4.7	1.1	2.2	-1.0
Family relationship satisfaction	0.6	0.7	1.1	0.3	0.9	-1.0
Leg pain on walking	0.1	0.1	0.3	0.6	0.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	-0.2	0.1	1.3
Commuting to job workplace: Car/motor vehicle	1.5	1.7	2.5	1.5	-0.6	1.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.5	0.2	1.2	-0.5
Medication: Aspirin	0.7	0.9	2.6	-0.1	1.6	-0.3
Supplements: Vitamin C	0.5	0.6	1.1	-0.5	-1.1	0.5
Knee pain experienced in last month	2.4	3.8	6.8	-2.6	-1.6	-1.4
Hypertension (Self-reported)	0.9	2.4	6.0	-2.4	0.3	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	-0.3	0.1	0.0
Illnesses of father: Heart disease	0.5	0.6	1.5	1.2	0.6	-0.2
Illnesses of siblings: Diabetes	0.6	0.8	1.0	-0.9	1.0	-0.8
Smoking status: Previous	0.3	0.4	1.0	0.3	1.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.9	-0.3	1.0	-1.4
Whole body fat-free mass	2.2	12.7	22.3	-3.1	2.5	-4.7
Leg fat-free mass (right)	2.1	11.0	20.1	-2.9	2.0	-4.5
Arm fat percentage (left)	1.2	4.7	11.0	-1.3	-3.3	1.2
Average weekly red wine intake	0.1	0.1	0.2	-0.3	0.2	0.5
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	0.5	0.2	0.8
Mood swings	0.2	0.3	1.0	0.0	1.0	-0.3
Loneliness, isolation	0.3	0.5	0.8	0.3	-0.9	0.7
Long-standing illness, disability or infirmity	2.4	3.7	6.8	-2.6	-0.2	-2.1
Ever had bowel cancer screening	0.2	0.3	0.5	-0.6	-0.7	0.0
Diabetes diagnosed by doctor	2.0	3.2	7.5	0.5	-1.4	2.7
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.4	0.9	1.5	0.9
Friendships satisfaction	0.8	1.0	2.5	1.6	0.0	0.7
Qualifications: nursing, teaching	1.1	1.8	3.0	1.7	1.2	0.9
Commuting to job workplace: Walk	0.5	0.6	1.3	-1.2	0.5	-0.4
Eye problems/disorders: Cataract	1.3	1.5	3.2	-0.6	1.0	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.0	1.0	0.3	1.0
Medication for cholesterol	1.5	2.3	3.3	1.6	-1.0	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.4	0.2	1.2	0.2
Back pain experienced in last month	1.8	2.7	4.1	-2.0	-0.6	-1.9
Mineral and other dietary supplements	1.1	1.5	2.9	1.1	0.3	1.7
Breast cancer (self-reported)	1.0	1.2	2.3	-0.9	0.7	-1.5
Asthma (self-reported)	1.4	2.9	4.3	-2.1	0.2	-2.1
Osteoporosis (self-reported)	0.2	0.2	0.5	0.7	0.4	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.9	-0.2	-0.1
Medication: Aspirin	0.5	0.6	1.5	-0.3	1.2	-0.6
Medication: Gliclazide	5.5	6.3	11.1	2.7	-0.4	3.3
Illnesses of father: None of the above (group 1)	0.9	1.1	2.1	-1.1	-1.4	-0.1
Smoking status: Current	0.3	0.6	0.9	1.0	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.6	0.7	0.1	0.8
Whole body water mass	2.4	13.9	24.5	-3.3	2.6	-4.9
Leg predicted mass (right)	2.0	10.6	19.4	-2.9	2.0	-4.4
Arm fat mass (left)	0.9	3.6	5.2	-2.3	-2.3	-0.6
Number of self-reported non-cancer illnesses	2.2	3.9	7.6	-2.8	-0.3	-2.0
Average weekly champagne plus white wine intake	2.4	3.3	6.4	2.5	0.6	1.8
Miserableness	0.0	0.0	0.1	-0.0	0.2	-0.2
Guilty feelings	0.4	0.6	1.7	-1.3	0.3	0.1
Wears glasses or contact lenses	0.5	0.6	0.9	0.7	-0.6	0.9
Ever taken oral contraceptive pill	0.9	1.0	2.5	-0.7	-1.6	0.0
Hearing aid user	0.2	0.2	0.3	-0.3	0.5	-0.5
Mother’s age at death	0.6	0.8	1.8	-0.3	0.6	-1.4
Financial situation satisfaction	0.3	0.3	0.7	-0.1	-0.9	-0.5
Tinnitus: Yes, now most or all of the time	5.2	6.1	10.2	0.4	3.2	-2.8
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.4	0.2	-0.6
Eye problems/disorders: Glaucoma	0.8	1.0	2.0	-1.4	-0.9	-0.3
Medication: Blood pressure	1.2	2.2	3.8	-1.9	0.8	-1.5
Pain type(s) experienced in last month: Hip pain	2.7	3.3	6.0	-1.9	-2.5	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.9	-0.3	0.1	-1.4
High cholesterol (Self-reported)	0.5	0.9	1.4	-1.2	0.4	-1.1
Medication: Bendroflumethiazide	1.5	2.3	3.8	-0.9	1.5	-1.9
Medication: Paracetamol	0.5	0.8	1.7	-1.3	-0.8	-0.4
Medication: Lisinopril	0.5	0.7	1.4	-0.7	0.1	-1.2
Medication: Atorvastatin	0.5	0.6	0.8	-0.9	-0.9	-0.5
Illnesses of father: High blood pressure	0.6	0.7	1.5	1.2	0.7	0.3
Alcohol drinker status: Never	2.6	3.1	4.4	-2.1	-0.7	-2.1
Ever smoked	0.3	0.5	1.2	1.1	0.5	-0.2
Basal metabolic rate	2.0	11.1	19.4	-3.2	1.8	-4.4
Leg fat percentage (left)	2.3	8.3	15.4	-0.5	-3.9	3.0
Arm fat-free mass (left)	1.8	8.9	15.4	-2.9	1.7	-3.9
Number of operations (self-reported)	0.9	1.4	2.4	-1.6	-0.1	-1.3
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.2	-0.2	-0.7
Irritability	0.2	0.4	0.6	-0.8	0.4	-0.7
Risk taking	0.0	0.0	0.0	-0.0	0.2	0.2
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.5	-1.6	-0.4	-1.0
Fractured/broken bones in last 5 years	1.4	1.9	2.8	-0.2	1.7	-1.7
Age started oral contraceptive pill	2.7	3.4	6.1	-2.5	-0.6	-1.9
Diastolic blood pressure, automated reading	0.6	1.8	2.7	1.0	-1.3	1.6
Ever depressed for a whole week	0.7	0.8	1.7	-1.3	-0.7	-0.5
Unable to work because of sickness or disability	1.5	1.9	2.8	-1.6	-1.7	0.6
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.3	0.2	-0.7
Myopia	0.1	0.2	0.4	0.5	-0.1	0.6
Vascular/heart problems diagnosed by doctor	0.9	2.5	5.0	2.2	-0.1	1.6
Cholesterol lowering medication	1.8	2.7	3.9	-2.0	0.9	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.8	-0.6	-0.8	0.9
Pain experienced in last month	1.7	2.9	5.2	2.3	1.7	0.8
Supplements: Calcium	0.2	0.2	0.5	0.2	-0.1	-0.7
Basal cell carcinoma (self-reported)	0.5	0.6	1.0	-0.5	-1.0	-0.9
Heart attack/myocardial infarction (self-reported)	3.5	4.6	7.1	-2.7	-2.2	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.5	-0.7	-0.7	0.5
Heart disease (siblings)	0.6	0.7	1.5	0.1	1.2	-0.8
Alcohol drinker status: Previous	1.9	2.2	5.5	-0.6	-2.4	0.9
Pack years of smoking	0.9	1.3	3.4	-0.6	-1.8	-0.0
Impedance of whole body	0.3	1.8	2.7	1.0	-1.2	1.7
Leg fat mass (left)	1.0	4.0	9.2	-1.5	-3.0	0.8
Arm predicted mass (left)	1.8	9.2	15.7	-3.0	1.7	-4.0