Hub : Genes

SLC38A4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0590	0.0270	0.0016	0.011	0.017	0.014	0.017	0.015	0.013	0.00340	0.0075	0.0029	0.00590
2	TCGA	Bladder Urothelial Carcinoma	0.0690	0.0400	0.0080	0.015	0.037	0.031	NA	0.044	0.017	0.00039	0.0011	NA	0.00013
3	TCGA	Breast Invasive Carcinoma	0.0338	0.0209	0.0061	0.000	0.006	0.007	NA	-0.001	0.270	0.01900	0.0100	NA	0.47000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.2	2.9	-0.8	-1.7	-0.1
Bipolar Disorder or Schizophrenia	0.1	0.4	0.5	-0.7	-0.6	0.4
Depressed Affect (Nagel 2018)	0.3	0.6	1.3	1.1	-0.1	-0.7
Depression (Nagel 2018)	0.9	1.4	3.2	1.8	0.9	-0.4
Intelligence (Savage-Jansen 2018)	0.8	2.4	5.5	0.7	-2.4	-1.0
Neuroticism (Nagel 2018)	0.0	0.0	0.0	-0.1	0.0	-0.1
Schizophrenia (2018)	0.2	0.3	0.6	-0.3	0.6	0.8
Schizophrenia vs Biploar Disorder	1.3	1.8	3.7	-0.1	1.3	1.9
Worry (Nagel 2018)	0.4	0.9	1.5	-0.5	0.9	1.2
Alzheimer’s Disease (in mother)	0.2	0.3	0.4	-0.6	-0.4	0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.0	-0.5	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.5	1.2	-0.5	0.1	1.1
Crohns Disease (2017)	0.3	0.7	1.4	-0.5	-0.7	1.2
Irritable Bowel Disease (IBD)	0.8	1.9	3.0	-1.7	-0.4	1.5
Ulcerative Colitis (UC)	0.7	1.4	3.2	-1.8	-0.1	1.0
Major Depression (MDD)	1.0	1.3	3.5	-0.3	1.9	0.4
Reaction Time	1.9	3.7	10.2	-3.2	0.8	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.7	-0.0	-1.3	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.2	0.2	0.6	0.3	-0.3	-0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	4.1	5.9	11.0	-1.9	-3.3	-1.8
Bipolar Disorder (2011)	0.2	0.2	0.4	0.3	-0.7	-0.1
Body Mass Index (BMI) (2010)	1.6	2.3	5.7	1.0	0.3	2.4
Coronary Artery Disease (CAD)	0.6	0.7	1.9	0.4	-1.4	0.3
Crohns Disease (2012)	0.7	1.1	3.3	-0.3	-1.8	0.2
Mean Putamen Volume	1.6	1.8	2.9	-1.1	-1.2	-1.7
Fasting Glucose	0.4	0.4	1.3	0.0	0.3	-1.1
HbA1C	0.7	0.8	2.1	-0.0	-0.5	-1.4
HDL Cholesterol	0.3	0.5	0.9	-0.7	-0.9	-0.3
LDL Cholesterol	0.1	0.2	0.4	0.4	0.3	0.7
Lupus	0.1	0.2	0.5	-0.1	-0.7	-0.4
Neuroticism (2016)	0.4	0.6	1.7	0.1	1.3	-0.4
Primary Biliary Cirrhosis	0.8	1.1	2.6	-0.8	-1.6	0.2
Rheumatoid Arthritis	0.9	1.3	2.0	1.4	-0.7	-1.2
Schizophrenia (2014)	0.6	1.2	2.1	-0.3	1.2	1.5
Triglycerides	0.1	0.1	0.3	0.5	-0.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	-0.6	-1.0	0.3
Ulcerative Colitis	0.7	1.1	3.1	-1.7	-0.0	0.5
Blood Eosinophil Count	1.8	13.7	25.7	-5.1	-3.7	1.4
Blood Platelet Count	2.2	25.0	47.7	-3.7	-6.9	3.7
Blood Red Count	0.1	0.9	1.9	0.5	1.4	-0.7
Blood White Count	0.3	2.5	6.4	0.7	2.5	-0.8
Heel T-Score	0.7	5.9	15.9	4.0	-0.5	-1.2
BMI	0.3	1.9	4.4	2.1	1.0	0.5
Height	2.1	39.5	96.0	4.3	-9.8	-2.0
Waist Hip Ratio (WHR)	0.7	3.1	8.5	-0.8	-2.9	0.3
Systolic Blood Pressure	0.3	1.5	2.7	-1.6	1.3	-0.5
Smoking Status	0.7	1.6	2.6	1.6	0.4	-1.4
Allergy or Eczema	1.2	3.1	4.5	-2.0	2.1	1.0
Cardiovascular Disease	0.4	1.4	1.8	-1.3	-1.3	-0.8
Hypothyroidism (self reported)	1.5	3.4	8.8	3.0	-0.8	0.9
Respiratory disease	2.1	4.7	6.6	-2.6	2.1	-1.8
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.4	0.1	-0.4
Lung FEV1/FVC ratio	0.4	2.0	4.5	2.1	-1.0	0.7
Lung FVC	1.1	5.8	17.1	4.1	-0.4	0.0
Neuroticism	0.3	0.6	1.2	0.5	0.6	-1.1
Chronotype (morning person)	0.6	1.4	2.3	1.0	1.5	-0.9
Hair Pigment	0.1	1.8	4.6	-2.1	-0.7	0.5
Tanning	0.2	2.2	3.9	2.0	0.9	-1.3
Hand grip strength (left)	2.2	5.8	13.5	3.7	-0.9	-1.7
Number of treatments/medications taken	0.9	1.7	2.8	-1.7	-0.4	1.4
Average weekly spirits intake	0.4	0.5	1.0	0.3	0.6	1.0
Sensitivity / hurt feelings	0.4	0.7	1.8	-1.4	-0.5	-0.1
Frequency of depressed mood in last 2 weeks	1.4	1.9	2.8	1.7	1.6	0.6
Hearing difficulty/problems: Yes	0.5	0.7	1.7	0.0	-0.7	1.3
Relative age of first facial hair	0.5	1.1	2.0	-1.0	-0.5	1.4
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.0	-1.0	-0.4	-1.4
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.6	1.1	-1.3	-0.5
Ever had hysterectomy (womb removed)	0.9	1.0	1.8	0.3	-1.0	-1.3
Systolic blood pressure, automated reading	0.2	0.6	1.7	-1.3	-0.1	0.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.7	1.9	-0.9	-0.2
Angina	1.2	1.5	3.1	0.3	1.8	-1.2
Medication for hormone replacement therapy	2.1	2.3	6.1	1.0	2.5	0.1
Vitamin and mineral supplements	1.9	2.5	3.2	1.7	1.3	-1.8
Supplements: Zinc	0.5	0.5	1.1	-1.0	-0.5	-0.4
Medication: Co-codamol	0.8	0.9	2.1	-0.0	-1.4	0.7
Medication: Metformin	0.5	0.7	1.7	0.6	-0.3	-1.3
Diabetes (father)	0.9	1.2	3.3	0.3	1.8	-0.4
Diabetes (mother)	0.2	0.3	0.4	-0.6	-0.5	0.6
Severe depression (siblings)	0.8	0.9	1.2	-0.8	1.0	-1.1
Pack years adult smoking proportion	0.3	0.5	0.9	1.0	-0.3	0.7
Impedance of leg (right)	1.6	7.7	15.6	-3.9	-2.1	1.8
Leg fat-free mass (left)	1.4	7.5	16.5	4.1	-1.3	-2.1
Trunk fat percentage	0.3	1.2	2.3	-0.6	-1.5	0.9
Hand grip strength (right)	1.7	4.8	9.2	2.0	-3.0	-1.0
Townsend deprivation index at recruitment	0.4	0.5	0.8	-0.8	0.9	-0.2
Current tobacco smoking	0.8	1.3	2.8	1.7	0.8	-0.7
Average weekly fortified wine intake	0.1	0.1	0.1	0.2	0.3	-0.3
Maternal smoking around birth	0.2	0.3	0.4	-0.6	-0.6	-0.2
Fed-up feelings	0.6	1.1	1.7	1.1	1.3	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	4.5	1.4	2.1	-1.2
Relative age voice broke	1.6	2.5	4.3	-1.1	-1.4	2.1
Taking other prescription medications	0.5	0.8	2.2	-1.5	0.1	-0.5
Age when periods started (menarche)	0.8	2.0	4.1	0.6	-2.0	1.2
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.5	0.4	-1.6	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.6	1.3	0.7	-1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.6	-0.4	0.7
Qualifications: CSEs or equivalent	1.4	1.9	2.2	1.5	1.3	1.3
Serious illness, injury or assault to yourself	0.8	0.9	2.0	0.2	0.9	-1.4
High blood pressure	1.4	3.8	7.6	-1.9	-2.8	0.5
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.7	-0.4	1.9	0.4
Multivitamins +/- minerals	0.2	0.2	0.3	-0.5	-0.5	0.3
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.5	-1.0	-0.2
Supplements: Glucosamine	1.8	2.3	3.1	-1.5	-1.8	1.2
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	-0.1	-0.1	0.0
Medication: Atenolol	1.6	2.0	4.4	-1.3	-2.1	0.2
Medication: Levothyroxine sodium	0.6	1.1	1.2	0.9	-1.1	1.1
Sitting height	1.9	13.5	33.4	5.8	-1.3	-2.3
Chronic bronchitis/emphysema (father)	0.9	1.0	2.0	-0.3	-0.9	1.4
High blood pressure (mother)	0.7	1.0	1.8	-0.3	1.1	1.3
Body mass index (BMI)	0.5	2.2	3.2	1.8	1.6	-0.9
Impedance of leg (left)	1.3	6.3	12.2	-3.5	-1.8	1.8
Leg predicted mass (left)	1.4	7.5	16.3	4.0	-1.3	-2.1
Trunk fat mass	0.2	1.0	2.7	0.5	-1.7	0.0
Waist circumference	0.6	2.1	3.1	1.4	-1.8	-1.1
Number of incorrect matches in round	1.3	2.2	5.5	-2.3	-0.7	-0.8
Past tobacco smoking	0.4	0.7	1.1	0.4	1.1	1.0
Alcohol usually taken with meals	0.4	0.6	1.2	-0.7	-0.3	-1.1
Nervous feelings	0.5	1.0	1.5	0.5	1.2	1.1
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	5.1	2.3	2.0	-0.6
Hearing difficulty/problems with background noise	0.7	1.1	1.6	1.0	0.8	-1.3
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.1	0.3	-0.7
Had menopause	0.3	0.3	0.8	0.2	-0.9	0.4
Had other major operations	0.6	0.7	1.3	0.8	-0.3	-1.2
Forced vital capacity (FVC)	1.6	6.1	12.3	3.5	-2.4	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.0	1.4	0.8	-1.0
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.1	-1.8	1.6	0.2
Qualifications: None of the above	0.0	0.1	0.1	0.2	-0.4	0.3
Financial difficulties in last 2 years	0.9	1.2	1.8	1.3	1.4	0.4
Mouth/teeth dental problems	0.2	0.4	0.9	1.0	-0.0	-0.5
Heart attack	0.9	1.2	2.2	0.4	1.5	-1.1
Allergy	0.7	1.6	2.9	1.3	-1.7	0.4
Pain all over the body in last month	3.0	3.2	7.9	-1.2	2.8	-0.6
Diabetes (self-reported)	0.2	0.3	0.4	-0.4	0.6	-0.7
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	2.7	-1.4	1.6	1.2
Medication: Ramipril	0.4	0.6	1.3	0.6	1.1	-0.2
Medication: Simvastatin	1.1	1.6	3.7	0.4	-0.9	-1.9
Fluid intelligence score	0.1	0.2	0.2	-0.5	-0.4	-0.4
Illnesses of siblings	0.5	0.6	1.1	1.1	0.9	-0.0
Neuroticism score	0.3	0.5	0.8	0.7	0.9	0.6
Weight	0.8	4.1	8.2	2.9	-1.3	-1.6
Impedance of arm (right)	2.6	11.9	15.5	-3.9	-3.4	3.0
Arm fat percentage (right)	0.0	0.2	0.5	0.2	0.2	0.7
Trunk fat-free mass	1.8	10.2	19.6	4.4	-1.4	-3.0
Hip circumference	0.6	2.8	4.2	2.0	-1.1	-1.7
Time employed in main current job	1.0	1.2	2.9	0.3	-1.7	0.7
Alcohol intake versus 10 years previously	0.6	1.0	1.7	1.1	0.1	-1.3
Father’s age at death	0.9	1.2	3.3	-0.5	-1.8	-0.0
Worrier / anxious feelings	1.1	2.1	3.1	-1.8	1.6	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.2	0.4	0.4	-0.4
Falls in the last year	0.3	0.4	0.8	-0.4	-0.4	0.9
Hair/balding pattern: Pattern 3	0.5	0.7	1.2	0.4	1.1	0.8
Number of live births	2.4	3.3	8.7	3.0	-0.2	1.1
Forced expiratory volume in 1-second (FEV1)	2.1	6.9	17.5	4.2	-1.7	-0.5
Pulse rate	0.1	0.1	0.2	0.4	0.5	-0.1
Happiness	0.4	0.5	1.0	-1.0	-0.6	0.3
Noisy workplace	0.4	0.5	1.0	1.0	0.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.2	0.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	-1.3	-0.7	0.6
Mouth/teeth dental problems: Dentures	1.5	2.5	7.4	-2.7	0.1	0.2
Asthma	1.6	3.2	6.8	-2.6	1.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.3	-0.0	0.0
Medication: Cholesterol lowering	0.4	0.6	1.2	0.7	-0.4	-1.1
Depression (self-reported)	0.1	0.1	0.3	0.0	0.3	0.6
Medication: Lansoprazole	0.3	0.3	0.8	-0.4	0.3	0.9
Prospective memory result	0.4	0.5	1.0	0.2	-1.0	0.5
Lung cancer (father)	1.2	1.4	1.5	1.2	1.1	-1.2
Illnesses of mother	1.9	2.3	5.5	1.0	0.6	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.5	12.2	3.5	-2.7	-0.5
Pulse wave Arterial Stiffness index	3.0	3.5	10.1	3.2	0.5	-0.3
Impedance of arm (left)	2.8	12.9	20.5	-4.5	-3.0	3.0
Arm fat mass (right)	0.2	0.8	2.3	1.5	-0.1	-0.4
Trunk predicted mass	1.7	9.8	18.6	4.3	-1.4	-3.0
Standing height	1.7	16.5	41.9	2.3	-6.5	-1.5
Length of working week for main job	0.3	0.4	0.6	0.7	-0.3	-0.8
Exposure to tobacco smoke at home	0.7	0.8	1.5	-1.2	-0.0	-0.9
Breastfed as a baby	0.6	0.8	1.6	0.8	-0.2	1.3
Tense / ‘highly strung’	0.4	0.7	1.6	0.7	1.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.5	-0.5	1.9	0.1
Hair/balding pattern: Pattern 4	0.3	0.7	2.0	1.4	0.3	0.1
Birth weight of first child	7.8	14.2	38.2	2.1	-6.2	0.3
Peak expiratory flow (PEF)	1.7	4.0	10.6	3.3	-1.1	0.2
Pulse wave reflection index	0.2	0.2	0.5	0.7	-0.5	-0.1
Ever highly irritable/argumentative for 2 days	2.0	2.3	4.3	-1.5	2.1	-0.8
Loud music exposure frequency	0.2	0.2	0.4	0.6	0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.3	0.3	-0.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	3.8	1.4	1.9	-0.0
Blood clot in the leg (DVT)	0.3	0.3	0.9	-0.1	-0.3	0.9
Medication: Paracetamol	0.1	0.2	0.7	0.2	0.0	0.8
Headache pain in last month	1.5	2.6	5.1	1.4	-0.9	-2.2
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	0.3	0.1	0.1
Glaucoma (self-reported)	6.7	7.9	20.2	1.7	4.5	-0.8
Gout (self-reported)	0.6	0.9	1.9	-0.8	-1.4	-0.1
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	3.2	1.8	-1.7	1.0
Medication: Amlodipine	0.2	0.3	0.5	-0.7	0.4	0.3
Medication: Ventolin 100micrograms inhaler	2.7	3.4	8.9	-3.0	1.2	-0.3
Birth weight	1.2	2.6	7.1	-0.7	-2.7	-0.0
Chronic bronchitis/emphysema (mother)	2.3	2.7	5.8	-2.4	-1.5	0.4
High blood pressure (siblings)	0.7	1.1	1.6	-1.3	-0.8	0.9
Forced vital capacity (FVC), Best measure	1.7	6.1	11.5	2.6	-3.4	-0.2
Body fat percentage	0.1	0.5	0.8	-0.4	-0.9	0.8
Leg fat percentage (right)	0.0	0.1	0.3	-0.1	0.2	0.6
Arm fat-free mass (right)	1.8	9.1	18.0	4.2	-1.1	-2.9
Exposure to tobacco smoke outside home	1.6	2.1	4.7	-2.2	0.5	1.2
Comparative body size at age 10	0.1	0.2	0.4	-0.0	0.6	-0.6
Number of full brothers	0.2	0.3	0.6	-0.8	-0.3	-0.2
Worry too long after embarrassment	0.1	0.1	0.2	-0.3	-0.2	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.8	-0.0	-0.2
Wheeze or whistling in the chest in last year	0.4	0.8	1.3	-1.0	1.1	-0.3
Number of children fathered	2.5	2.9	6.1	2.5	1.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	-0.7	0.1	-0.3
Age at first live birth	0.5	0.9	1.4	-0.1	-1.2	-1.1
Pulse wave peak to peak time	2.3	2.7	7.4	-2.7	-0.8	-0.0
Health satisfaction	0.3	0.3	0.8	-0.5	-0.2	-0.9
Shortness of breath walking on level ground	0.8	0.9	2.1	-0.0	0.9	-1.4
Qualifications: College or University degree	1.0	3.1	7.9	-2.8	-1.0	0.6
Eye problems/disorders: None of the above	0.4	0.5	0.8	-0.9	-0.6	0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	-0.9	-0.1	0.0
Emphysema/chronic bronchitis	0.6	0.7	0.9	-0.7	0.9	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.4	0.7	-0.2	0.8	0.8
Neck or shoulder pain in last month	0.7	0.9	2.4	1.6	0.2	-0.6
Medication: Blood pressure	0.4	0.6	1.1	-1.1	-0.1	0.9
Angina (self-reported)	1.3	1.7	2.9	0.3	1.7	-1.4
Migraine (self-reported)	1.7	2.1	3.5	-1.7	-1.9	-0.2
Medication: Ibuprofen	0.4	0.5	1.0	-0.3	1.0	0.6
Medication: Allopurinol	1.3	1.8	5.0	-0.5	-2.2	0.3
Medication: Omeprazole	0.9	1.1	1.7	-1.2	-1.3	-0.2
Medication: Seretide 50 evohaler	1.8	2.1	2.2	-1.4	-1.5	-1.4
Mean time to correctly identify matches	2.8	5.3	14.2	-3.8	-0.8	1.0
Heart disease (mother)	0.6	0.8	1.9	0.0	0.6	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	5.7	-0.2	2.4	-0.8
Whole body fat mass	0.2	0.6	1.4	0.7	-1.2	-0.2
Leg fat mass (right)	0.2	0.9	2.3	1.5	-0.3	-0.5
Arm predicted mass (right)	1.9	9.7	18.4	4.3	-0.9	-3.1
Pulse rate, automated reading	0.5	1.6	3.5	1.9	0.7	-0.8
Alcohol intake frequency.	0.3	0.8	2.0	-0.1	-1.4	0.5
Comparative height size at age 10	1.5	8.4	23.1	0.6	-4.8	-1.3
Number of full sisters	0.3	0.4	0.6	-0.2	-0.7	-0.8
Suffer from ‘nerves’	2.4	3.8	8.2	-0.5	1.7	2.9
Overall health rating	0.4	0.9	1.6	-1.3	0.9	-0.6
Chest pain or discomfort	0.0	0.1	0.1	-0.3	-0.1	0.2
Had major operations	0.6	0.7	1.6	-1.3	-0.4	-0.4
Age at last live birth	0.3	0.4	0.7	-0.8	-0.7	-0.4
Family relationship satisfaction	1.0	1.3	3.3	-1.8	0.1	-0.7
Leg pain on walking	0.4	0.5	0.9	0.8	1.0	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.8	0.6	0.9	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	-0.3	-0.1	-0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.5	0.4	-0.7	-0.6
Medication: Aspirin	1.0	1.3	2.0	-0.4	-1.3	-1.4
Supplements: Vitamin C	0.5	0.6	0.8	-0.9	0.5	0.9
Knee pain experienced in last month	0.1	0.1	0.2	-0.2	0.0	-0.5
Hypertension (Self-reported)	0.9	2.6	5.0	-1.5	-2.2	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	0.3	0.9	-1.0
Illnesses of father: Heart disease	1.6	2.3	4.4	-0.2	1.5	2.1
Illnesses of siblings: Diabetes	0.4	0.5	1.4	-1.2	0.1	-0.2
Smoking status: Previous	0.2	0.3	0.4	-0.2	-0.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	2.3	0.5	-1.5	-1.5
Whole body fat-free mass	1.7	9.9	20.4	4.5	-1.3	-2.8
Leg fat-free mass (right)	1.5	8.0	19.1	4.4	-1.0	-2.0
Arm fat percentage (left)	0.1	0.3	0.7	-0.1	0.4	0.8
Average weekly red wine intake	0.2	0.3	0.5	0.5	0.7	0.4
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.7	-1.3	-0.9	-0.4
Mood swings	1.2	2.2	5.8	0.8	2.4	0.5
Loneliness, isolation	0.3	0.4	0.8	0.9	0.5	-0.5
Long-standing illness, disability or infirmity	1.7	2.5	4.5	-2.1	1.4	-1.0
Ever had bowel cancer screening	1.2	1.4	2.5	-0.6	-1.6	1.2
Diabetes diagnosed by doctor	0.3	0.5	1.3	0.3	0.4	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.1	0.8	1.8	1.2
Friendships satisfaction	1.5	1.8	2.9	-1.4	-1.7	-0.8
Qualifications: nursing, teaching	0.2	0.3	0.5	0.2	0.6	0.7
Commuting to job workplace: Walk	0.6	0.7	1.3	-1.1	0.6	-0.7
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.2	-0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.0	-0.0	-1.4	-0.5
Medication for cholesterol	0.1	0.1	0.3	0.1	0.6	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.4	1.7	1.9	0.2
Back pain experienced in last month	0.8	1.1	2.9	1.7	0.4	-0.4
Mineral and other dietary supplements	0.5	0.7	1.1	0.6	1.1	-0.8
Breast cancer (self-reported)	1.8	2.2	4.0	-0.4	-2.0	-1.5
Asthma (self-reported)	1.5	3.1	6.2	-2.5	1.3	-1.2
Osteoporosis (self-reported)	1.0	1.3	2.2	-1.3	-1.5	-0.0
Osteoarthritis (self-reported)	0.0	0.1	0.1	-0.2	-0.1	0.3
Medication: Aspirin	0.7	0.9	1.7	-0.8	-0.8	-1.3
Medication: Gliclazide	2.2	2.5	4.2	2.0	0.9	-1.6
Illnesses of father: None of the above (group 1)	1.0	1.3	2.0	1.4	-1.1	-0.8
Smoking status: Current	0.5	0.8	1.7	1.3	0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.7	10.7	3.3	-0.3	0.6
Whole body water mass	1.8	10.0	20.6	4.5	-1.3	-2.8
Leg predicted mass (right)	1.5	8.0	19.3	4.4	-1.0	-2.0
Arm fat mass (left)	0.2	0.6	1.8	1.3	-0.2	-0.3
Number of self-reported non-cancer illnesses	1.3	2.3	6.0	-2.5	-0.0	-1.0
Average weekly champagne plus white wine intake	1.6	2.2	5.6	-2.4	-0.8	0.6
Miserableness	0.7	1.2	3.7	1.9	-0.1	-0.1
Guilty feelings	0.4	0.6	1.6	-0.3	1.3	0.3
Wears glasses or contact lenses	0.1	0.1	0.3	0.5	0.3	-0.1
Ever taken oral contraceptive pill	1.0	1.2	1.7	1.3	1.2	0.6
Hearing aid user	1.6	1.8	4.0	0.7	-2.0	-0.9
Mother’s age at death	0.1	0.1	0.2	-0.3	0.4	-0.3
Financial situation satisfaction	1.1	1.4	3.8	0.2	2.0	-0.6
Tinnitus: Yes, now most or all of the time	1.3	1.6	3.4	-0.6	-0.9	1.8
Commuting to job workplace: Public transport	0.2	0.3	0.5	-0.4	-0.7	0.4
Eye problems/disorders: Glaucoma	6.7	7.9	18.4	2.2	4.3	-0.5
Medication: Blood pressure	1.6	3.0	4.5	-2.1	-2.1	0.2
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.2	0.7	1.1	-1.5
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.1	-1.1	-0.6	0.7
High cholesterol (Self-reported)	0.2	0.3	0.7	0.0	-0.4	-0.8
Medication: Bendroflumethiazide	0.8	1.2	1.8	-1.3	-1.2	0.8
Medication: Paracetamol	0.8	1.2	3.0	0.1	0.7	1.7
Medication: Lisinopril	0.4	0.5	1.6	-0.2	0.1	1.3
Medication: Atorvastatin	0.9	1.1	1.9	-1.1	-1.4	-0.5
Illnesses of father: High blood pressure	0.3	0.4	0.6	-0.7	0.8	-0.2
Alcohol drinker status: Never	0.4	0.5	0.6	-0.7	-0.5	0.8
Ever smoked	0.6	1.1	2.6	-0.0	-0.8	-1.6
Basal metabolic rate	1.5	8.5	17.5	4.2	-1.3	-2.5
Leg fat percentage (left)	0.0	0.1	0.1	0.3	0.3	0.3
Arm fat-free mass (left)	1.8	9.3	18.6	4.3	-0.9	-2.9
Number of operations (self-reported)	1.5	2.2	3.9	1.0	-1.3	-2.0
Average weekly beer plus cider intake	0.8	1.1	2.3	0.6	1.5	0.8
Irritability	0.5	0.9	1.3	1.1	0.8	0.9
Risk taking	0.2	0.3	0.6	0.1	0.5	-0.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.9	0.2	-1.4	-0.6
Fractured/broken bones in last 5 years	0.3	0.5	0.8	-0.4	-0.9	-0.6
Age started oral contraceptive pill	2.6	3.2	8.0	0.6	-2.8	1.1
Diastolic blood pressure, automated reading	0.0	0.1	0.2	0.1	0.3	-0.5
Ever depressed for a whole week	0.8	1.0	2.7	-1.7	0.6	-0.1
Unable to work because of sickness or disability	0.9	1.1	3.3	0.2	1.8	-0.1
Commuting to job workplace: Cycle	0.6	0.7	1.2	1.1	0.6	0.7
Myopia	0.6	0.9	2.2	0.1	1.5	0.8
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.7	1.4	1.9	-0.1
Cholesterol lowering medication	0.5	0.8	1.2	-0.1	-1.0	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.5	-1.0	-0.7	-1.2
Pain experienced in last month	0.2	0.3	0.5	-0.7	0.4	0.6
Supplements: Calcium	1.6	1.8	3.6	-1.4	-1.9	0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.7	0.3	0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.3	-0.0	1.1	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	-0.1	-0.2	0.2
Heart disease (siblings)	0.5	0.6	1.8	-1.4	0.1	-0.1
Alcohol drinker status: Previous	0.8	1.0	2.5	-1.6	-0.3	0.5
Pack years of smoking	0.6	0.8	1.1	0.9	-0.8	1.1
Impedance of whole body	2.3	11.8	19.5	-4.4	-2.8	2.9
Leg fat mass (left)	0.3	1.1	2.8	1.7	-0.4	-0.6
Arm predicted mass (left)	1.9	9.8	18.3	4.3	-1.3	-3.1