Hub : Genes

SLC38A4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0590 0.0270 0.0016 0.011 0.017 0.014 0.017 0.015 0.013 0.00340 0.0075 0.0029 0.00590
2 TCGA Bladder Urothelial Carcinoma 0.0690 0.0400 0.0080 0.015 0.037 0.031 NA 0.044 0.017 0.00039 0.0011 NA 0.00013
3 TCGA Breast Invasive Carcinoma 0.0338 0.0209 0.0061 0.000 0.006 0.007 NA -0.001 0.270 0.01900 0.0100 NA 0.47000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.2 2.9 -0.8 -1.7 -0.1
Bipolar Disorder or Schizophrenia 0.1 0.4 0.5 -0.7 -0.6 0.4
Depressed Affect (Nagel 2018) 0.3 0.6 1.3 1.1 -0.1 -0.7
Depression (Nagel 2018) 0.9 1.4 3.2 1.8 0.9 -0.4
Intelligence (Savage-Jansen 2018) 0.8 2.4 5.5 0.7 -2.4 -1.0
Neuroticism (Nagel 2018) 0.0 0.0 0.0 -0.1 0.0 -0.1
Schizophrenia (2018) 0.2 0.3 0.6 -0.3 0.6 0.8
Schizophrenia vs Biploar Disorder 1.3 1.8 3.7 -0.1 1.3 1.9
Worry (Nagel 2018) 0.4 0.9 1.5 -0.5 0.9 1.2
Alzheimer’s Disease (in mother) 0.2 0.3 0.4 -0.6 -0.4 0.6
Alzheimer’s Disease (in father) 0.1 0.1 0.3 0.0 -0.5 -0.1
Alzheimer’s Disease (including proxy) 0.3 0.5 1.2 -0.5 0.1 1.1
Crohns Disease (2017) 0.3 0.7 1.4 -0.5 -0.7 1.2
Irritable Bowel Disease (IBD) 0.8 1.9 3.0 -1.7 -0.4 1.5
Ulcerative Colitis (UC) 0.7 1.4 3.2 -1.8 -0.1 1.0
Major Depression (MDD) 1.0 1.3 3.5 -0.3 1.9 0.4
Reaction Time 1.9 3.7 10.2 -3.2 0.8 0.6
Verbal and Numeric Reasoning (VNR) 0.2 0.6 1.7 -0.0 -1.3 -0.2
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.2 0.2 0.6 0.3 -0.3 -0.8
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 4.1 5.9 11.0 -1.9 -3.3 -1.8
Bipolar Disorder (2011) 0.2 0.2 0.4 0.3 -0.7 -0.1
Body Mass Index (BMI) (2010) 1.6 2.3 5.7 1.0 0.3 2.4
Coronary Artery Disease (CAD) 0.6 0.7 1.9 0.4 -1.4 0.3
Crohns Disease (2012) 0.7 1.1 3.3 -0.3 -1.8 0.2
Mean Putamen Volume 1.6 1.8 2.9 -1.1 -1.2 -1.7
Fasting Glucose 0.4 0.4 1.3 0.0 0.3 -1.1
HbA1C 0.7 0.8 2.1 -0.0 -0.5 -1.4
HDL Cholesterol 0.3 0.5 0.9 -0.7 -0.9 -0.3
LDL Cholesterol 0.1 0.2 0.4 0.4 0.3 0.7
Lupus 0.1 0.2 0.5 -0.1 -0.7 -0.4
Neuroticism (2016) 0.4 0.6 1.7 0.1 1.3 -0.4
Primary Biliary Cirrhosis 0.8 1.1 2.6 -0.8 -1.6 0.2
Rheumatoid Arthritis 0.9 1.3 2.0 1.4 -0.7 -1.2
Schizophrenia (2014) 0.6 1.2 2.1 -0.3 1.2 1.5
Triglycerides 0.1 0.1 0.3 0.5 -0.1 -0.3
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.1 -0.6 -1.0 0.3
Ulcerative Colitis 0.7 1.1 3.1 -1.7 -0.0 0.5
Blood Eosinophil Count 1.8 13.7 25.7 -5.1 -3.7 1.4
Blood Platelet Count 2.2 25.0 47.7 -3.7 -6.9 3.7
Blood Red Count 0.1 0.9 1.9 0.5 1.4 -0.7
Blood White Count 0.3 2.5 6.4 0.7 2.5 -0.8
Heel T-Score 0.7 5.9 15.9 4.0 -0.5 -1.2
BMI 0.3 1.9 4.4 2.1 1.0 0.5
Height 2.1 39.5 96.0 4.3 -9.8 -2.0
Waist Hip Ratio (WHR) 0.7 3.1 8.5 -0.8 -2.9 0.3
Systolic Blood Pressure 0.3 1.5 2.7 -1.6 1.3 -0.5
Smoking Status 0.7 1.6 2.6 1.6 0.4 -1.4
Allergy or Eczema 1.2 3.1 4.5 -2.0 2.1 1.0
Cardiovascular Disease 0.4 1.4 1.8 -1.3 -1.3 -0.8
Hypothyroidism (self reported) 1.5 3.4 8.8 3.0 -0.8 0.9
Respiratory disease 2.1 4.7 6.6 -2.6 2.1 -1.8
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.2 -0.4 0.1 -0.4
Lung FEV1/FVC ratio 0.4 2.0 4.5 2.1 -1.0 0.7
Lung FVC 1.1 5.8 17.1 4.1 -0.4 0.0
Neuroticism 0.3 0.6 1.2 0.5 0.6 -1.1
Chronotype (morning person) 0.6 1.4 2.3 1.0 1.5 -0.9
Hair Pigment 0.1 1.8 4.6 -2.1 -0.7 0.5
Tanning 0.2 2.2 3.9 2.0 0.9 -1.3
Hand grip strength (left) 2.2 5.8 13.5 3.7 -0.9 -1.7
Number of treatments/medications taken 0.9 1.7 2.8 -1.7 -0.4 1.4
Average weekly spirits intake 0.4 0.5 1.0 0.3 0.6 1.0
Sensitivity / hurt feelings 0.4 0.7 1.8 -1.4 -0.5 -0.1
Frequency of depressed mood in last 2 weeks 1.4 1.9 2.8 1.7 1.6 0.6
Hearing difficulty/problems: Yes 0.5 0.7 1.7 0.0 -0.7 1.3
Relative age of first facial hair 0.5 1.1 2.0 -1.0 -0.5 1.4
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.0 -1.0 -0.4 -1.4
Ever used hormone-replacement therapy (HRT) 0.8 1.0 1.6 1.1 -1.3 -0.5
Ever had hysterectomy (womb removed) 0.9 1.0 1.8 0.3 -1.0 -1.3
Systolic blood pressure, automated reading 0.2 0.6 1.7 -1.3 -0.1 0.2
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 3.7 1.9 -0.9 -0.2
Angina 1.2 1.5 3.1 0.3 1.8 -1.2
Medication for hormone replacement therapy 2.1 2.3 6.1 1.0 2.5 0.1
Vitamin and mineral supplements 1.9 2.5 3.2 1.7 1.3 -1.8
Supplements: Zinc 0.5 0.5 1.1 -1.0 -0.5 -0.4
Medication: Co-codamol 0.8 0.9 2.1 -0.0 -1.4 0.7
Medication: Metformin 0.5 0.7 1.7 0.6 -0.3 -1.3
Diabetes (father) 0.9 1.2 3.3 0.3 1.8 -0.4
Diabetes (mother) 0.2 0.3 0.4 -0.6 -0.5 0.6
Severe depression (siblings) 0.8 0.9 1.2 -0.8 1.0 -1.1
Pack years adult smoking proportion 0.3 0.5 0.9 1.0 -0.3 0.7
Impedance of leg (right) 1.6 7.7 15.6 -3.9 -2.1 1.8
Leg fat-free mass (left) 1.4 7.5 16.5 4.1 -1.3 -2.1
Trunk fat percentage 0.3 1.2 2.3 -0.6 -1.5 0.9
Hand grip strength (right) 1.7 4.8 9.2 2.0 -3.0 -1.0
Townsend deprivation index at recruitment 0.4 0.5 0.8 -0.8 0.9 -0.2
Current tobacco smoking 0.8 1.3 2.8 1.7 0.8 -0.7
Average weekly fortified wine intake 0.1 0.1 0.1 0.2 0.3 -0.3
Maternal smoking around birth 0.2 0.3 0.4 -0.6 -0.6 -0.2
Fed-up feelings 0.6 1.1 1.7 1.1 1.3 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.6 4.5 1.4 2.1 -1.2
Relative age voice broke 1.6 2.5 4.3 -1.1 -1.4 2.1
Taking other prescription medications 0.5 0.8 2.2 -1.5 0.1 -0.5
Age when periods started (menarche) 0.8 2.0 4.1 0.6 -2.0 1.2
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.5 0.4 -1.6 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.6 1.3 0.7 -1.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.5 0.6 -0.4 0.7
Qualifications: CSEs or equivalent 1.4 1.9 2.2 1.5 1.3 1.3
Serious illness, injury or assault to yourself 0.8 0.9 2.0 0.2 0.9 -1.4
High blood pressure 1.4 3.8 7.6 -1.9 -2.8 0.5
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.7 -0.4 1.9 0.4
Multivitamins +/- minerals 0.2 0.2 0.3 -0.5 -0.5 0.3
Stomach or abdominal pain in last month 0.3 0.4 0.9 0.5 -1.0 -0.2
Supplements: Glucosamine 1.8 2.3 3.1 -1.5 -1.8 1.2
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 -0.1 -0.1 0.0
Medication: Atenolol 1.6 2.0 4.4 -1.3 -2.1 0.2
Medication: Levothyroxine sodium 0.6 1.1 1.2 0.9 -1.1 1.1
Sitting height 1.9 13.5 33.4 5.8 -1.3 -2.3
Chronic bronchitis/emphysema (father) 0.9 1.0 2.0 -0.3 -0.9 1.4
High blood pressure (mother) 0.7 1.0 1.8 -0.3 1.1 1.3
Body mass index (BMI) 0.5 2.2 3.2 1.8 1.6 -0.9
Impedance of leg (left) 1.3 6.3 12.2 -3.5 -1.8 1.8
Leg predicted mass (left) 1.4 7.5 16.3 4.0 -1.3 -2.1
Trunk fat mass 0.2 1.0 2.7 0.5 -1.7 0.0
Waist circumference 0.6 2.1 3.1 1.4 -1.8 -1.1
Number of incorrect matches in round 1.3 2.2 5.5 -2.3 -0.7 -0.8
Past tobacco smoking 0.4 0.7 1.1 0.4 1.1 1.0
Alcohol usually taken with meals 0.4 0.6 1.2 -0.7 -0.3 -1.1
Nervous feelings 0.5 1.0 1.5 0.5 1.2 1.1
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.2 5.1 2.3 2.0 -0.6
Hearing difficulty/problems with background noise 0.7 1.1 1.6 1.0 0.8 -1.3
Hair/balding pattern: Pattern 2 0.2 0.2 0.5 -0.1 0.3 -0.7
Had menopause 0.3 0.3 0.8 0.2 -0.9 0.4
Had other major operations 0.6 0.7 1.3 0.8 -0.3 -1.2
Forced vital capacity (FVC) 1.6 6.1 12.3 3.5 -2.4 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.0 1.4 0.8 -1.0
Ever unenthusiastic/disinterested for a whole week 1.6 1.9 3.1 -1.8 1.6 0.2
Qualifications: None of the above 0.0 0.1 0.1 0.2 -0.4 0.3
Financial difficulties in last 2 years 0.9 1.2 1.8 1.3 1.4 0.4
Mouth/teeth dental problems 0.2 0.4 0.9 1.0 -0.0 -0.5
Heart attack 0.9 1.2 2.2 0.4 1.5 -1.1
Allergy 0.7 1.6 2.9 1.3 -1.7 0.4
Pain all over the body in last month 3.0 3.2 7.9 -1.2 2.8 -0.6
Diabetes (self-reported) 0.2 0.3 0.4 -0.4 0.6 -0.7
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 2.7 -1.4 1.6 1.2
Medication: Ramipril 0.4 0.6 1.3 0.6 1.1 -0.2
Medication: Simvastatin 1.1 1.6 3.7 0.4 -0.9 -1.9
Fluid intelligence score 0.1 0.2 0.2 -0.5 -0.4 -0.4
Illnesses of siblings 0.5 0.6 1.1 1.1 0.9 -0.0
Neuroticism score 0.3 0.5 0.8 0.7 0.9 0.6
Weight 0.8 4.1 8.2 2.9 -1.3 -1.6
Impedance of arm (right) 2.6 11.9 15.5 -3.9 -3.4 3.0
Arm fat percentage (right) 0.0 0.2 0.5 0.2 0.2 0.7
Trunk fat-free mass 1.8 10.2 19.6 4.4 -1.4 -3.0
Hip circumference 0.6 2.8 4.2 2.0 -1.1 -1.7
Time employed in main current job 1.0 1.2 2.9 0.3 -1.7 0.7
Alcohol intake versus 10 years previously 0.6 1.0 1.7 1.1 0.1 -1.3
Father’s age at death 0.9 1.2 3.3 -0.5 -1.8 -0.0
Worrier / anxious feelings 1.1 2.1 3.1 -1.8 1.6 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.2 0.4 0.4 -0.4
Falls in the last year 0.3 0.4 0.8 -0.4 -0.4 0.9
Hair/balding pattern: Pattern 3 0.5 0.7 1.2 0.4 1.1 0.8
Number of live births 2.4 3.3 8.7 3.0 -0.2 1.1
Forced expiratory volume in 1-second (FEV1) 2.1 6.9 17.5 4.2 -1.7 -0.5
Pulse rate 0.1 0.1 0.2 0.4 0.5 -0.1
Happiness 0.4 0.5 1.0 -1.0 -0.6 0.3
Noisy workplace 0.4 0.5 1.0 1.0 0.2 -0.7
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.4 -0.2 0.2 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.7 -1.3 -0.7 0.6
Mouth/teeth dental problems: Dentures 1.5 2.5 7.4 -2.7 0.1 0.2
Asthma 1.6 3.2 6.8 -2.6 1.2 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.1 0.3 -0.0 0.0
Medication: Cholesterol lowering 0.4 0.6 1.2 0.7 -0.4 -1.1
Depression (self-reported) 0.1 0.1 0.3 0.0 0.3 0.6
Medication: Lansoprazole 0.3 0.3 0.8 -0.4 0.3 0.9
Prospective memory result 0.4 0.5 1.0 0.2 -1.0 0.5
Lung cancer (father) 1.2 1.4 1.5 1.2 1.1 -1.2
Illnesses of mother 1.9 2.3 5.5 1.0 0.6 -2.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.5 12.2 3.5 -2.7 -0.5
Pulse wave Arterial Stiffness index 3.0 3.5 10.1 3.2 0.5 -0.3
Impedance of arm (left) 2.8 12.9 20.5 -4.5 -3.0 3.0
Arm fat mass (right) 0.2 0.8 2.3 1.5 -0.1 -0.4
Trunk predicted mass 1.7 9.8 18.6 4.3 -1.4 -3.0
Standing height 1.7 16.5 41.9 2.3 -6.5 -1.5
Length of working week for main job 0.3 0.4 0.6 0.7 -0.3 -0.8
Exposure to tobacco smoke at home 0.7 0.8 1.5 -1.2 -0.0 -0.9
Breastfed as a baby 0.6 0.8 1.6 0.8 -0.2 1.3
Tense / ‘highly strung’ 0.4 0.7 1.6 0.7 1.3 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 3.5 -0.5 1.9 0.1
Hair/balding pattern: Pattern 4 0.3 0.7 2.0 1.4 0.3 0.1
Birth weight of first child 7.8 14.2 38.2 2.1 -6.2 0.3
Peak expiratory flow (PEF) 1.7 4.0 10.6 3.3 -1.1 0.2
Pulse wave reflection index 0.2 0.2 0.5 0.7 -0.5 -0.1
Ever highly irritable/argumentative for 2 days 2.0 2.3 4.3 -1.5 2.1 -0.8
Loud music exposure frequency 0.2 0.2 0.4 0.6 0.2 -0.5
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 0.3 0.3 -0.5
Mouth/teeth dental problems: Bleeding gums 1.4 1.9 3.8 1.4 1.9 -0.0
Blood clot in the leg (DVT) 0.3 0.3 0.9 -0.1 -0.3 0.9
Medication: Paracetamol 0.1 0.2 0.7 0.2 0.0 0.8
Headache pain in last month 1.5 2.6 5.1 1.4 -0.9 -2.2
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.1 0.3 0.1 0.1
Glaucoma (self-reported) 6.7 7.9 20.2 1.7 4.5 -0.8
Gout (self-reported) 0.6 0.9 1.9 -0.8 -1.4 -0.1
Hypothyroidism/myxoedema (self-reported) 1.2 2.4 3.2 1.8 -1.7 1.0
Medication: Amlodipine 0.2 0.3 0.5 -0.7 0.4 0.3
Medication: Ventolin 100micrograms inhaler 2.7 3.4 8.9 -3.0 1.2 -0.3
Birth weight 1.2 2.6 7.1 -0.7 -2.7 -0.0
Chronic bronchitis/emphysema (mother) 2.3 2.7 5.8 -2.4 -1.5 0.4
High blood pressure (siblings) 0.7 1.1 1.6 -1.3 -0.8 0.9
Forced vital capacity (FVC), Best measure 1.7 6.1 11.5 2.6 -3.4 -0.2
Body fat percentage 0.1 0.5 0.8 -0.4 -0.9 0.8
Leg fat percentage (right) 0.0 0.1 0.3 -0.1 0.2 0.6
Arm fat-free mass (right) 1.8 9.1 18.0 4.2 -1.1 -2.9
Exposure to tobacco smoke outside home 1.6 2.1 4.7 -2.2 0.5 1.2
Comparative body size at age 10 0.1 0.2 0.4 -0.0 0.6 -0.6
Number of full brothers 0.2 0.3 0.6 -0.8 -0.3 -0.2
Worry too long after embarrassment 0.1 0.1 0.2 -0.3 -0.2 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.6 -0.8 -0.0 -0.2
Wheeze or whistling in the chest in last year 0.4 0.8 1.3 -1.0 1.1 -0.3
Number of children fathered 2.5 2.9 6.1 2.5 1.2 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.5 -0.7 0.1 -0.3
Age at first live birth 0.5 0.9 1.4 -0.1 -1.2 -1.1
Pulse wave peak to peak time 2.3 2.7 7.4 -2.7 -0.8 -0.0
Health satisfaction 0.3 0.3 0.8 -0.5 -0.2 -0.9
Shortness of breath walking on level ground 0.8 0.9 2.1 -0.0 0.9 -1.4
Qualifications: College or University degree 1.0 3.1 7.9 -2.8 -1.0 0.6
Eye problems/disorders: None of the above 0.4 0.5 0.8 -0.9 -0.6 0.6
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.8 -0.9 -0.1 0.0
Emphysema/chronic bronchitis 0.6 0.7 0.9 -0.7 0.9 -0.8
Medication for pain relief, constipation, heartburn 0.3 0.4 0.7 -0.2 0.8 0.8
Neck or shoulder pain in last month 0.7 0.9 2.4 1.6 0.2 -0.6
Medication: Blood pressure 0.4 0.6 1.1 -1.1 -0.1 0.9
Angina (self-reported) 1.3 1.7 2.9 0.3 1.7 -1.4
Migraine (self-reported) 1.7 2.1 3.5 -1.7 -1.9 -0.2
Medication: Ibuprofen 0.4 0.5 1.0 -0.3 1.0 0.6
Medication: Allopurinol 1.3 1.8 5.0 -0.5 -2.2 0.3
Medication: Omeprazole 0.9 1.1 1.7 -1.2 -1.3 -0.2
Medication: Seretide 50 evohaler 1.8 2.1 2.2 -1.4 -1.5 -1.4
Mean time to correctly identify matches 2.8 5.3 14.2 -3.8 -0.8 1.0
Heart disease (mother) 0.6 0.8 1.9 0.0 0.6 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.8 2.1 5.7 -0.2 2.4 -0.8
Whole body fat mass 0.2 0.6 1.4 0.7 -1.2 -0.2
Leg fat mass (right) 0.2 0.9 2.3 1.5 -0.3 -0.5
Arm predicted mass (right) 1.9 9.7 18.4 4.3 -0.9 -3.1
Pulse rate, automated reading 0.5 1.6 3.5 1.9 0.7 -0.8
Alcohol intake frequency. 0.3 0.8 2.0 -0.1 -1.4 0.5
Comparative height size at age 10 1.5 8.4 23.1 0.6 -4.8 -1.3
Number of full sisters 0.3 0.4 0.6 -0.2 -0.7 -0.8
Suffer from ‘nerves’ 2.4 3.8 8.2 -0.5 1.7 2.9
Overall health rating 0.4 0.9 1.6 -1.3 0.9 -0.6
Chest pain or discomfort 0.0 0.1 0.1 -0.3 -0.1 0.2
Had major operations 0.6 0.7 1.6 -1.3 -0.4 -0.4
Age at last live birth 0.3 0.4 0.7 -0.8 -0.7 -0.4
Family relationship satisfaction 1.0 1.3 3.3 -1.8 0.1 -0.7
Leg pain on walking 0.4 0.5 0.9 0.8 1.0 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 0.8 0.6 0.9 0.7
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.7 -0.3 -0.1 -0.8
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.5 0.4 -0.7 -0.6
Medication: Aspirin 1.0 1.3 2.0 -0.4 -1.3 -1.4
Supplements: Vitamin C 0.5 0.6 0.8 -0.9 0.5 0.9
Knee pain experienced in last month 0.1 0.1 0.2 -0.2 0.0 -0.5
Hypertension (Self-reported) 0.9 2.6 5.0 -1.5 -2.2 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.0 0.3 0.9 -1.0
Illnesses of father: Heart disease 1.6 2.3 4.4 -0.2 1.5 2.1
Illnesses of siblings: Diabetes 0.4 0.5 1.4 -1.2 0.1 -0.2
Smoking status: Previous 0.2 0.3 0.4 -0.2 -0.6 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 2.3 0.5 -1.5 -1.5
Whole body fat-free mass 1.7 9.9 20.4 4.5 -1.3 -2.8
Leg fat-free mass (right) 1.5 8.0 19.1 4.4 -1.0 -2.0
Arm fat percentage (left) 0.1 0.3 0.7 -0.1 0.4 0.8
Average weekly red wine intake 0.2 0.3 0.5 0.5 0.7 0.4
Handedness (chirality/laterality): Left-handed 0.8 0.9 1.7 -1.3 -0.9 -0.4
Mood swings 1.2 2.2 5.8 0.8 2.4 0.5
Loneliness, isolation 0.3 0.4 0.8 0.9 0.5 -0.5
Long-standing illness, disability or infirmity 1.7 2.5 4.5 -2.1 1.4 -1.0
Ever had bowel cancer screening 1.2 1.4 2.5 -0.6 -1.6 1.2
Diabetes diagnosed by doctor 0.3 0.5 1.3 0.3 0.4 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 3.1 0.8 1.8 1.2
Friendships satisfaction 1.5 1.8 2.9 -1.4 -1.7 -0.8
Qualifications: nursing, teaching 0.2 0.3 0.5 0.2 0.6 0.7
Commuting to job workplace: Walk 0.6 0.7 1.3 -1.1 0.6 -0.7
Eye problems/disorders: Cataract 0.1 0.1 0.3 -0.2 -0.6 0.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.0 -0.0 -1.4 -0.5
Medication for cholesterol 0.1 0.1 0.3 0.1 0.6 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.1 3.4 1.7 1.9 0.2
Back pain experienced in last month 0.8 1.1 2.9 1.7 0.4 -0.4
Mineral and other dietary supplements 0.5 0.7 1.1 0.6 1.1 -0.8
Breast cancer (self-reported) 1.8 2.2 4.0 -0.4 -2.0 -1.5
Asthma (self-reported) 1.5 3.1 6.2 -2.5 1.3 -1.2
Osteoporosis (self-reported) 1.0 1.3 2.2 -1.3 -1.5 -0.0
Osteoarthritis (self-reported) 0.0 0.1 0.1 -0.2 -0.1 0.3
Medication: Aspirin 0.7 0.9 1.7 -0.8 -0.8 -1.3
Medication: Gliclazide 2.2 2.5 4.2 2.0 0.9 -1.6
Illnesses of father: None of the above (group 1) 1.0 1.3 2.0 1.4 -1.1 -0.8
Smoking status: Current 0.5 0.8 1.7 1.3 0.5 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.8 3.7 10.7 3.3 -0.3 0.6
Whole body water mass 1.8 10.0 20.6 4.5 -1.3 -2.8
Leg predicted mass (right) 1.5 8.0 19.3 4.4 -1.0 -2.0
Arm fat mass (left) 0.2 0.6 1.8 1.3 -0.2 -0.3
Number of self-reported non-cancer illnesses 1.3 2.3 6.0 -2.5 -0.0 -1.0
Average weekly champagne plus white wine intake 1.6 2.2 5.6 -2.4 -0.8 0.6
Miserableness 0.7 1.2 3.7 1.9 -0.1 -0.1
Guilty feelings 0.4 0.6 1.6 -0.3 1.3 0.3
Wears glasses or contact lenses 0.1 0.1 0.3 0.5 0.3 -0.1
Ever taken oral contraceptive pill 1.0 1.2 1.7 1.3 1.2 0.6
Hearing aid user 1.6 1.8 4.0 0.7 -2.0 -0.9
Mother’s age at death 0.1 0.1 0.2 -0.3 0.4 -0.3
Financial situation satisfaction 1.1 1.4 3.8 0.2 2.0 -0.6
Tinnitus: Yes, now most or all of the time 1.3 1.6 3.4 -0.6 -0.9 1.8
Commuting to job workplace: Public transport 0.2 0.3 0.5 -0.4 -0.7 0.4
Eye problems/disorders: Glaucoma 6.7 7.9 18.4 2.2 4.3 -0.5
Medication: Blood pressure 1.6 3.0 4.5 -2.1 -2.1 0.2
Pain type(s) experienced in last month: Hip pain 1.0 1.3 2.2 0.7 1.1 -1.5
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.1 -1.1 -0.6 0.7
High cholesterol (Self-reported) 0.2 0.3 0.7 0.0 -0.4 -0.8
Medication: Bendroflumethiazide 0.8 1.2 1.8 -1.3 -1.2 0.8
Medication: Paracetamol 0.8 1.2 3.0 0.1 0.7 1.7
Medication: Lisinopril 0.4 0.5 1.6 -0.2 0.1 1.3
Medication: Atorvastatin 0.9 1.1 1.9 -1.1 -1.4 -0.5
Illnesses of father: High blood pressure 0.3 0.4 0.6 -0.7 0.8 -0.2
Alcohol drinker status: Never 0.4 0.5 0.6 -0.7 -0.5 0.8
Ever smoked 0.6 1.1 2.6 -0.0 -0.8 -1.6
Basal metabolic rate 1.5 8.5 17.5 4.2 -1.3 -2.5
Leg fat percentage (left) 0.0 0.1 0.1 0.3 0.3 0.3
Arm fat-free mass (left) 1.8 9.3 18.6 4.3 -0.9 -2.9
Number of operations (self-reported) 1.5 2.2 3.9 1.0 -1.3 -2.0
Average weekly beer plus cider intake 0.8 1.1 2.3 0.6 1.5 0.8
Irritability 0.5 0.9 1.3 1.1 0.8 0.9
Risk taking 0.2 0.3 0.6 0.1 0.5 -0.8
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.9 0.2 -1.4 -0.6
Fractured/broken bones in last 5 years 0.3 0.5 0.8 -0.4 -0.9 -0.6
Age started oral contraceptive pill 2.6 3.2 8.0 0.6 -2.8 1.1
Diastolic blood pressure, automated reading 0.0 0.1 0.2 0.1 0.3 -0.5
Ever depressed for a whole week 0.8 1.0 2.7 -1.7 0.6 -0.1
Unable to work because of sickness or disability 0.9 1.1 3.3 0.2 1.8 -0.1
Commuting to job workplace: Cycle 0.6 0.7 1.2 1.1 0.6 0.7
Myopia 0.6 0.9 2.2 0.1 1.5 0.8
Vascular/heart problems diagnosed by doctor 0.7 1.9 3.7 1.4 1.9 -0.1
Cholesterol lowering medication 0.5 0.8 1.2 -0.1 -1.0 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.5 -1.0 -0.7 -1.2
Pain experienced in last month 0.2 0.3 0.5 -0.7 0.4 0.6
Supplements: Calcium 1.6 1.8 3.6 -1.4 -1.9 0.1
Basal cell carcinoma (self-reported) 0.2 0.2 0.6 0.7 0.3 0.1
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.3 -0.0 1.1 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.1 -0.1 -0.2 0.2
Heart disease (siblings) 0.5 0.6 1.8 -1.4 0.1 -0.1
Alcohol drinker status: Previous 0.8 1.0 2.5 -1.6 -0.3 0.5
Pack years of smoking 0.6 0.8 1.1 0.9 -0.8 1.1
Impedance of whole body 2.3 11.8 19.5 -4.4 -2.8 2.9
Leg fat mass (left) 0.3 1.1 2.8 1.7 -0.4 -0.6
Arm predicted mass (left) 1.9 9.8 18.3 4.3 -1.3 -3.1