TWAS hub - HGFAC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1151	0.0316	5.5e-06	0.077	0.030	0.045	0.039	0.068	4.2e-10	9.1e-05	1.7e-06	7.9e-06	4.4e-09
2	TCGA	Breast Invasive Carcinoma	0.0268	0.0157	9.9e-03	0.010	0.014	0.011	NA	0.010	2.7e-03	4.9e-04	1.9e-03	NA	3.1e-03
3	TCGA	Prostate Adenocarcinoma	0.0529	0.0234	1.1e-03	0.050	0.026	0.040	NA	0.053	6.1e-06	8.5e-04	4.5e-05	NA	3.0e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Platelet Count	6.5	75.9	144.0	-12.0	-4.1	-8.2
Financial difficulties in last 2 years	6.4	8.6	9.9	2.8	3.1	2.9
Number of full brothers	4.7	5.9	11.0	1.7	3.3	2.0
Breast Cancer	4.5	10.9	12.5	-2.9	-3.5	-3.5
Rheumatoid Arthritis	4.5	6.1	9.3	1.9	3.0	2.4
Medication: Amlodipine	4.5	6.3	10.5	-3.2	-1.6	-2.4
Commuting to job workplace: Public transport	4.5	5.4	5.7	-2.3	-2.3	-2.4
Townsend deprivation index at recruitment	4.2	5.9	6.5	2.5	2.5	2.2
LDL Cholesterol	4.1	6.4	14.1	-3.8	-0.9	-2.1
Chronic bronchitis/emphysema (father)	3.9	4.5	7.0	2.7	1.6	2.0
Illness, injury, bereavement, stress in last 2 years	3.8	4.7	5.6	-1.8	-2.4	-2.3
Triglycerides	3.4	5.6	14.7	-3.8	0.1	-1.5
Stomach or abdominal pain in last month	3.4	4.2	5.2	-2.3	-1.7	-2.1
Number of live births	3.4	4.8	7.2	2.7	1.1	2.4
Illnesses of siblings: Diabetes	3.4	4.2	6.1	1.9	1.7	2.5
Alcohol drinker status: Never	3.2	3.9	5.6	-2.4	-1.8	-1.7
Irritable Bowel Disease (IBD)	3.0	7.2	16.0	-4.0	-0.0	-2.4
Worrier / anxious feelings	2.8	5.3	8.0	-1.7	-2.8	-2.2
Sitting height	2.7	18.9	42.1	6.5	0.8	3.7
Comparative height size at age 10	2.6	14.5	30.9	5.6	1.2	3.3
Heart disease (siblings)	2.6	3.2	4.0	1.8	2.0	1.6
Ulcerative Colitis (UC)	2.5	4.7	9.3	-3.1	0.2	-2.2
Height	2.5	47.9	110.2	10.5	1.3	5.6
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	4.9	-1.6	-2.2	-2.1
Average weekly champagne plus white wine intake	2.5	3.5	5.2	-1.4	-2.3	-1.8
Heel T-Score	2.3	18.4	34.0	5.8	1.8	4.2
Financial situation satisfaction	2.3	2.8	4.1	1.4	2.0	1.5
Pain experienced in last month	2.2	3.6	3.8	-1.9	-1.8	-1.9
Intelligence (Savage-Jansen 2018)	2.1	6.4	7.3	-2.3	-2.5	-2.7
Relative age voice broke	2.1	3.3	4.4	-1.8	-2.1	-1.5
Noisy workplace	2.1	2.6	4.1	1.2	2.0	1.5
Qualifications: College or University degree	2.1	6.7	10.4	-1.8	-3.2	-2.5
Medication for cholesterol	2.1	3.2	4.4	2.1	1.6	1.6
Relative age of first facial hair	2.0	4.2	5.1	-2.2	-1.8	-2.0
Multivitamins +/- minerals	2.0	2.6	2.7	1.6	1.6	1.6
Length of working week for main job	2.0	2.2	3.3	1.8	1.0	1.5
Neck or shoulder pain in last month	2.0	2.9	3.4	1.6	1.9	1.6
Fasting Glucose	1.9	2.3	2.5	-1.4	-1.6	-1.5
Hearing difficulty/problems: Yes	1.9	2.9	3.1	-1.8	-1.6	-1.7
Nervous feelings	1.9	3.5	6.2	-1.0	-2.5	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	4.8	2.2	-0.1	1.4
Crohns Disease (2017)	1.8	3.8	9.1	-3.0	-0.5	-1.5
Qualifications: A levels/AS levels or equivalent	1.8	3.9	7.1	-1.2	-2.7	-1.8
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	2.6	1.3	1.5	1.6
Average weekly red wine intake	1.8	2.6	4.8	2.2	0.7	1.6
Friendships satisfaction	1.8	2.2	3.3	1.4	1.8	1.2
Qualifications: nursing, teaching	1.8	2.8	2.9	-1.7	-1.7	-1.6
Medication: Bendroflumethiazide	1.8	2.7	3.8	-1.9	-1.2	-1.7
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.3	1.8	1.0	1.4
Fluid intelligence score	1.7	3.5	5.1	-1.5	-2.2	-1.8
Falls in the last year	1.6	2.2	3.3	1.8	0.4	1.8
Shortness of breath walking on level ground	1.6	2.0	2.8	-1.7	-1.4	-1.0
Overall health rating	1.6	3.5	5.3	1.1	2.3	2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.0	1.2	1.3	1.4
Impedance of leg (left)	1.5	7.2	13.8	-3.7	-1.0	-2.6
Loud music exposure frequency	1.5	1.6	1.9	1.3	1.2	1.4
Average weekly beer plus cider intake	1.5	2.1	4.2	1.0	2.1	1.1
Worry (Nagel 2018)	1.4	3.0	3.6	-1.4	-1.8	-1.9
Verbal and Numeric Reasoning (VNR)	1.4	3.5	6.9	-0.9	-2.6	-1.6
Prostate Cancer	1.4	2.0	3.2	1.8	1.1	1.3
Supplements: Zinc	1.4	1.6	1.9	1.4	1.2	1.2
Diabetes (father)	1.4	1.7	2.8	0.9	1.7	1.2
Smoking status: Previous	1.4	2.0	2.4	1.5	1.4	1.3
High cholesterol (Self-reported)	1.4	2.4	7.2	-2.7	0.2	-0.3
HDL Cholesterol	1.3	2.2	3.7	1.9	0.9	1.4
Smoking Status	1.3	3.2	3.9	1.6	1.8	2.0
Cardiovascular Disease	1.3	4.3	12.3	-3.5	-0.0	-0.7
Chronotype (morning person)	1.3	2.9	4.4	-1.9	-1.0	-2.1
Medication for hormone replacement therapy	1.3	1.4	2.5	-1.0	-1.6	-0.9
Average weekly fortified wine intake	1.3	1.5	2.6	-1.6	-0.6	-1.2
Past tobacco smoking	1.3	2.3	2.6	-1.6	-1.4	-1.5
Trunk fat-free mass	1.3	7.6	17.9	4.2	-0.2	2.2
Trunk predicted mass	1.3	7.6	17.7	4.2	-0.2	2.2
Standing height	1.3	12.6	32.1	5.7	-0.3	2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	2.5	-1.6	-1.3	-0.9
Medication: Allopurinol	1.3	1.8	2.4	-1.3	-1.6	-1.1
Whole body fat-free mass	1.3	7.4	17.4	4.2	-0.3	2.2
Systolic Blood Pressure	1.2	6.0	14.6	-3.8	1.4	-1.2
Leg fat-free mass (left)	1.2	6.6	15.4	3.9	-0.1	2.0
Leg predicted mass (left)	1.2	6.5	15.4	3.9	-0.1	2.0
Asthma	1.2	2.3	2.6	-1.5	-1.6	-1.5
Pulse wave Arterial Stiffness index	1.2	1.4	2.1	1.4	0.5	1.4
Glaucoma (self-reported)	1.2	1.4	2.1	1.3	0.6	1.4
Breast cancer (self-reported)	1.2	1.4	2.3	-1.5	-0.3	-1.4
Whole body water mass	1.2	7.1	16.6	4.1	-0.4	2.1
Medication: Paracetamol	1.2	1.9	2.5	-1.6	-1.5	-1.0
Cholesterol lowering medication	1.2	1.7	4.0	-2.0	-0.6	-0.9
Ever used hormone-replacement therapy (HRT)	1.1	1.4	1.7	1.0	1.3	1.2
Pack years adult smoking proportion	1.1	1.6	2.6	0.5	1.6	1.4
Taking other prescription medications	1.1	1.7	2.6	1.3	1.0	1.6
Arm fat-free mass (right)	1.1	5.5	12.1	3.5	-0.7	2.0
Age at first live birth	1.1	1.9	2.5	-1.2	-1.4	-1.6
Ever taken oral contraceptive pill	1.1	1.2	2.9	-0.2	-1.7	-0.8
Pack years of smoking	1.1	1.6	3.0	0.6	1.7	1.2
Age at First Birth	1.0	1.5	1.9	-0.8	-1.3	-1.4
Hypothyroidism (self reported)	1.0	2.4	6.1	0.3	2.5	1.0
Lung FEV1/FVC ratio	1.0	4.8	10.0	-3.2	-0.7	-2.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.4	-1.2	-0.9	-1.6
Hearing difficulty/problems with background noise	1.0	1.6	3.4	-0.0	-1.8	-1.1
Forced vital capacity (FVC)	1.0	3.8	7.2	2.7	-2.0	0.5
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	3.7	0.9	1.9	1.2
Arm predicted mass (right)	1.0	5.3	11.4	3.4	-0.4	2.1
Suffer from ‘nerves’	1.0	1.5	3.2	-0.5	-1.8	-1.1
Family relationship satisfaction	1.0	1.2	1.7	-1.1	0.8	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.7	-0.4	-1.6	-0.8
Number of self-reported non-cancer illnesses	1.0	1.7	3.4	0.2	1.8	1.3
Basal metabolic rate	1.0	5.6	13.3	3.6	-0.5	1.8
Qualifications: CSEs or equivalent	0.9	1.3	1.3	-1.1	-1.1	-1.1
Gout (self-reported)	0.9	1.2	2.3	-1.5	-0.7	-1.0
Forced vital capacity (FVC), Best measure	0.9	3.4	7.0	2.6	-1.6	0.8
Health satisfaction	0.9	1.1	1.3	0.9	1.1	1.1
Knee pain experienced in last month	0.9	1.5	2.9	1.7	0.4	1.1
Leg fat-free mass (right)	0.9	5.0	12.0	3.5	-0.5	1.6
Leg predicted mass (right)	0.9	5.0	12.1	3.5	-0.5	1.6
Arm fat-free mass (left)	0.9	4.6	10.4	3.2	-0.6	1.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.2	2.3	1.1	0.0	1.5
Arm predicted mass (left)	0.9	4.5	10.2	3.2	-0.8	1.6
Schizophrenia vs Biploar Disorder	0.8	1.1	1.8	0.9	1.3	0.8
Ever had hysterectomy (womb removed)	0.8	1.0	2.8	0.0	1.7	0.2
Severe depression (siblings)	0.8	0.9	2.4	0.0	1.6	0.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.9	1.4	0.2	0.8
Had other major operations	0.8	1.0	1.8	0.8	0.6	1.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	5.7	1.4	-2.4	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	1.3	0.9	1.1	0.9
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.0	1.4	0.1	0.9
Worry too long after embarrassment	0.8	1.3	3.6	1.9	-0.2	0.4
Medication: Blood pressure	0.8	1.4	2.7	-1.6	-0.8	-0.9
Long-standing illness, disability or infirmity	0.8	1.2	2.0	0.6	1.1	1.4
Alzheimer’s Disease (in father)	0.7	0.7	1.1	-1.0	-0.1	-1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	1.7	-0.7	-0.9	-1.3
Coronary Artery Disease (CAD)	0.7	0.9	2.2	-0.7	-0.2	-1.5
Crohns Disease (2012)	0.7	1.2	2.6	-1.6	0.9	-0.2
Number of treatments/medications taken	0.7	1.3	2.1	-1.2	-1.4	-0.7
Systolic blood pressure, automated reading	0.7	2.2	5.0	-2.2	0.9	-0.8
Medication: Atenolol	0.7	0.9	1.5	0.8	1.2	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.2	2.1	-0.2	0.8
Pain all over the body in last month	0.7	0.8	1.6	0.8	-0.2	1.3
Illnesses of siblings	0.7	1.0	1.6	-0.6	-1.1	-1.3
Time employed in main current job	0.7	0.9	2.2	0.6	-1.5	-0.0
Medication: Lansoprazole	0.7	0.8	2.2	0.1	-1.5	-0.2
Breastfed as a baby	0.7	0.9	1.7	-0.8	-0.7	-1.3
Birth weight of first child	0.7	1.2	3.3	-0.1	-1.8	-0.5
Peak expiratory flow (PEF)	0.7	1.5	3.9	2.0	-0.1	0.8
Angina (self-reported)	0.7	1.0	2.1	-1.5	0.7	-0.5
Migraine (self-reported)	0.7	0.8	1.2	-0.9	-0.7	-1.1
Asthma (self-reported)	0.7	1.4	1.8	-1.0	-1.3	-1.2
Medication: Gliclazide	0.7	0.8	2.0	-1.4	0.7	-0.2
Medication: Atorvastatin	0.7	0.9	2.5	-1.6	0.1	-0.5
Myopia	0.7	1.0	2.1	-1.5	-0.5	-0.8
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.0	-1.0	-1.0	-0.9
Bipolar Disorder (2018)	0.6	0.9	2.0	-0.5	-1.4	-0.7
Ulcerative Colitis	0.6	0.9	1.6	-1.3	0.9	-0.5
Lung FVC	0.6	3.2	6.2	2.5	-1.5	1.0
Impedance of leg (right)	0.6	2.7	5.8	-2.4	0.1	-1.5
Fed-up feelings	0.6	1.1	2.3	1.5	0.2	1.0
High blood pressure (mother)	0.6	0.8	1.4	-1.2	-0.5	-0.9
Number of incorrect matches in round	0.6	1.0	2.0	1.4	0.4	1.0
Alcohol usually taken with meals	0.6	1.0	2.6	-0.2	-1.6	-0.5
Had menopause	0.6	0.7	0.8	0.9	0.7	0.9
Weight	0.6	2.9	6.6	2.6	-0.4	1.4
Hair/balding pattern: Pattern 4	0.6	1.4	2.9	-1.7	-0.5	-1.0
Pulse wave reflection index	0.6	0.7	1.3	0.9	0.2	1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.9	0.3	1.4	0.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.8	1.7	-0.3	0.3
Pulse wave peak to peak time	0.6	0.7	1.1	-0.9	-0.4	-1.1
Emphysema/chronic bronchitis	0.6	0.7	1.3	-0.5	-0.8	-1.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.6	0.7	1.2	0.4
Mood swings	0.6	1.1	1.7	1.3	0.5	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.0	0.7	-1.7	-0.3
Risk taking	0.6	0.8	1.2	0.9	1.1	0.6
Unable to work because of sickness or disability	0.6	0.8	1.3	1.0	0.5	1.2
Impedance of whole body	0.6	3.2	6.1	-2.5	-0.2	-1.8
Body Mass Index (BMI) (2010)	0.5	0.7	0.9	0.9	0.5	0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.8	0.6	0.9	0.6
Angina	0.5	0.7	1.3	-1.2	0.8	-0.4
Medication: Levothyroxine sodium	0.5	0.9	1.2	0.7	1.1	0.9
Happiness	0.5	0.6	1.1	1.0	0.3	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.1	1.3	-1.8	0.1
Birth weight	0.5	1.0	2.8	0.2	-1.7	-0.5
Wheeze or whistling in the chest in last year	0.5	1.0	1.9	-0.5	-1.4	-0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	0.4	1.1	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	-0.3	1.3	0.3
Alcohol intake frequency.	0.5	1.1	3.0	-1.7	0.6	0.1
Leg pain on walking	0.5	0.6	1.1	-0.0	-1.1	-0.8
Hypertension (Self-reported)	0.5	1.4	3.5	-1.9	-0.5	-0.7
Osteoporosis (self-reported)	0.5	0.7	0.8	-0.8	-0.8	-0.9
Wears glasses or contact lenses	0.5	0.6	1.4	-0.6	-1.2	-0.1
Tinnitus: Yes, now most or all of the time	0.5	0.5	0.9	0.8	1.0	0.2
Eye problems/disorders: Glaucoma	0.5	0.6	0.9	0.9	-0.1	0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.2	1.1	0.8	0.2
Medication: Lisinopril	0.5	0.6	1.4	-0.5	-1.2	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.4	1.9	0.2	0.8
Reaction Time	0.4	0.7	1.1	1.1	0.7	0.7
HbA1C	0.4	0.5	0.8	0.2	0.9	0.7
Neuroticism (2016)	0.4	0.5	0.9	0.6	-1.0	-0.6
Blood White Count	0.4	3.0	8.2	-2.9	-0.4	-0.8
Hand grip strength (right)	0.4	1.0	2.0	1.4	0.2	1.0
High blood pressure	0.4	1.1	2.8	-1.7	-0.3	-0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	-0.8	-0.5	-0.8
Medication: Cholesterol lowering	0.4	0.6	1.8	-1.3	-0.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	0.6	-0.1	1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	-1.0	-0.2	-0.8
Exposure to tobacco smoke outside home	0.4	0.5	0.8	0.8	-0.2	0.9
Had major operations	0.4	0.5	0.8	-0.9	-0.3	-0.7
Supplements: Vitamin C	0.4	0.5	0.7	-0.8	0.6	-0.6
Illnesses of father: Heart disease	0.4	0.6	1.2	-1.1	0.8	-0.0
Medication: Aspirin	0.4	0.5	1.6	-0.1	-1.3	-0.1
Medication: Blood pressure	0.4	0.8	1.0	-1.0	-1.0	-0.8
Ovarian Cancer	0.3	0.4	0.9	0.9	0.3	0.5
Lupus	0.3	0.4	1.2	-0.1	-1.1	-0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.9	0.5	-0.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.4	-1.2	-0.4	-0.4
Average weekly spirits intake	0.3	0.3	0.5	0.6	0.7	0.4
Medication: Co-codamol	0.3	0.3	0.4	0.5	0.5	0.6
Diabetes (mother)	0.3	0.3	0.4	0.6	0.6	0.5
Current tobacco smoking	0.3	0.4	0.9	0.5	0.1	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.0	0.9	-1.0	-0.3
Serious illness, injury or assault to yourself	0.3	0.3	0.6	0.1	0.8	0.6
Supplements: Glucosamine	0.3	0.4	0.7	0.5	-0.5	-0.8
Heart attack	0.3	0.4	0.6	-0.6	-0.8	-0.6
Allergy	0.3	0.7	1.0	0.4	1.0	1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	-0.8	0.7	-0.2
Impedance of arm (right)	0.3	1.3	2.2	-1.3	0.3	-1.5
Alcohol intake versus 10 years previously	0.3	0.5	0.9	0.4	0.7	0.9
Father’s age at death	0.3	0.4	0.7	0.8	0.4	0.6
Prospective memory result	0.3	0.3	0.4	0.4	0.6	0.7
Exposure to tobacco smoke at home	0.3	0.3	0.5	0.6	0.2	0.7
Headache pain in last month	0.3	0.6	1.2	-0.6	-1.1	-0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	0.8	-0.6	0.6	-0.9
Mean time to correctly identify matches	0.3	0.6	1.6	1.2	0.3	0.6
Pulse rate, automated reading	0.3	0.9	1.1	-1.0	-0.8	-1.0
Number of full sisters	0.3	0.3	0.6	0.2	0.8	0.6
Chest pain or discomfort	0.3	0.4	1.1	-1.0	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.7	1.3	-0.3	0.3
Commuting to job workplace: Walk	0.3	0.4	0.6	0.6	0.8	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	-1.0	-0.4	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.0	0.3	-1.0	-0.4
Smoking status: Current	0.3	0.4	0.9	0.5	0.3	0.9
Alcohol drinker status: Previous	0.3	0.3	0.8	0.3	0.0	0.9
Depressed Affect (Nagel 2018)	0.2	0.4	0.6	0.8	0.5	0.6
Mean Putamen Volume	0.2	0.2	0.4	-0.2	-0.5	-0.6
Waist Hip Ratio (WHR)	0.2	0.9	1.8	-0.9	1.3	0.0
Allergy or Eczema	0.2	0.5	0.8	-0.1	-0.9	-0.8
Neuroticism	0.2	0.4	0.8	0.9	0.3	0.7
Hand grip strength (left)	0.2	0.4	1.1	1.0	-0.1	0.5
Vitamin and mineral supplements	0.2	0.2	0.4	-0.5	-0.6	-0.2
Maternal smoking around birth	0.2	0.3	0.4	0.7	-0.6	0.4
Age when periods started (menarche)	0.2	0.5	0.6	-0.8	-0.4	-0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	0.5	0.0	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-0.4	-0.5	-0.9
Trunk fat mass	0.2	0.7	1.3	1.1	-0.1	0.8
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	-0.4	0.8	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	0.2	0.3	0.8
Qualifications: None of the above	0.2	0.4	0.7	0.1	0.8	0.8
Medication: Simvastatin	0.2	0.4	0.8	-0.9	0.4	0.4
Hip circumference	0.2	0.9	2.2	1.5	-0.4	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	-0.2	0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	0.3	0.7	0.5
Illnesses of mother	0.2	0.2	0.7	0.2	-0.8	0.1
Impedance of arm (left)	0.2	1.1	1.7	-1.3	0.3	-1.2
Tense / ‘highly strung’	0.2	0.3	0.5	-0.3	-0.7	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.6	-0.1	-0.5
Medication: Omeprazole	0.2	0.3	0.5	0.4	-0.4	0.7
Leg fat mass (right)	0.2	0.6	0.9	0.9	-0.2	0.9
Medication: Aspirin	0.2	0.3	0.9	0.0	-0.9	0.1
Ever had bowel cancer screening	0.2	0.2	0.4	0.3	0.6	0.4
Mineral and other dietary supplements	0.2	0.2	0.6	-0.8	-0.0	0.3
Mother’s age at death	0.2	0.2	0.5	-0.1	-0.7	-0.4
Ever smoked	0.2	0.4	0.8	0.9	0.1	0.6
Leg fat percentage (left)	0.2	0.7	1.5	-1.2	-0.7	-0.3
Age started oral contraceptive pill	0.2	0.2	0.7	0.0	0.8	0.0
Ever depressed for a whole week	0.2	0.3	0.6	-0.2	0.4	0.8
Commuting to job workplace: Cycle	0.2	0.3	0.7	0.9	-0.0	0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	0.7	0.3	0.4
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.7	-0.4	-0.1
Neuroticism (Nagel 2018)	0.1	0.2	0.5	0.1	-0.7	-0.5
Schizophrenia (2014)	0.1	0.2	0.4	0.5	0.7	0.2
Blood Eosinophil Count	0.1	0.9	2.3	0.2	-1.5	-0.4
Blood Red Count	0.1	1.3	2.9	1.7	0.5	0.9
BMI	0.1	0.6	1.8	-1.4	-0.2	-0.2
Hair Pigment	0.1	2.0	4.2	-2.0	-0.6	-1.2
Sensitivity / hurt feelings	0.1	0.2	0.3	0.6	-0.4	-0.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	-0.0	-0.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.2	0.2	0.4
Waist circumference	0.1	0.2	0.4	0.6	-0.2	0.4
Medication: Ramipril	0.1	0.2	0.3	-0.3	-0.5	-0.3
Neuroticism score	0.1	0.2	0.3	0.4	-0.6	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.1	0.1	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.2	0.5	0.3	0.4
Medication: Paracetamol	0.1	0.2	0.5	-0.4	-0.7	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.1	0.4	0.3
High blood pressure (siblings)	0.1	0.2	0.3	-0.4	0.3	0.5
Comparative body size at age 10	0.1	0.3	0.7	-0.8	0.4	0.1
Number of children fathered	0.1	0.1	0.1	0.4	-0.3	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.6	0.1	0.2
Medication: Ibuprofen	0.1	0.1	0.1	-0.1	-0.3	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	-0.1	0.3
Whole body fat mass	0.1	0.5	1.0	1.0	-0.2	0.7
Age at last live birth	0.1	0.1	0.1	0.3	-0.4	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	-0.7	0.0	-0.1
Eye problems/disorders: Cataract	0.1	0.2	0.5	-0.1	0.7	-0.0
Back pain experienced in last month	0.1	0.1	0.3	-0.1	-0.6	-0.2
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.1	0.6	0.5
Arm fat mass (left)	0.1	0.2	0.3	0.5	-0.5	0.3
Miserableness	0.1	0.2	0.4	0.2	-0.2	0.6
Guilty feelings	0.1	0.2	0.4	0.0	-0.7	-0.2
Hearing aid user	0.1	0.1	0.3	0.5	-0.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.4	0.4	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.5	0.2	0.1
Irritability	0.1	0.1	0.3	-0.6	0.1	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.5	-0.0	0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.6	-0.8	-0.2	-0.2
Supplements: Calcium	0.1	0.1	0.2	0.4	0.4	0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.4	0.4	-0.3
Leg fat mass (left)	0.1	0.2	0.4	0.3	-0.6	0.3
Depression (Nagel 2018)	0.0	0.0	0.1	0.0	-0.0	0.2
Schizophrenia (2018)	0.0	0.1	0.2	0.0	0.2	-0.5
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.2	-0.2	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.1	-0.2	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.1	0.1	-0.4	-0.0	0.2
Respiratory disease	0.0	0.0	0.1	0.1	-0.3	0.0
Tanning	0.0	0.4	1.1	0.3	1.0	0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	-0.1	0.2	0.3
Medication: Metformin	0.0	0.0	0.1	-0.0	-0.0	0.3
Trunk fat percentage	0.0	0.0	0.0	-0.2	-0.2	0.1
Body mass index (BMI)	0.0	0.1	0.1	-0.1	-0.3	0.3
Mouth/teeth dental problems	0.0	0.0	0.0	0.1	-0.1	0.1
Diabetes (self-reported)	0.0	0.1	0.1	0.2	-0.0	0.4
Arm fat percentage (right)	0.0	0.2	0.4	-0.6	-0.1	-0.4
Pulse rate	0.0	0.1	0.2	-0.2	-0.1	-0.4
Depression (self-reported)	0.0	0.0	0.1	-0.1	-0.3	0.0
Lung cancer (father)	0.0	0.0	0.0	0.1	0.0	-0.0
Arm fat mass (right)	0.0	0.1	0.2	0.4	-0.4	0.2
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.3	-0.2	-0.0
Body fat percentage	0.0	0.1	0.2	-0.4	-0.2	0.0
Leg fat percentage (right)	0.0	0.1	0.2	-0.5	-0.0	0.4
Heart disease (mother)	0.0	0.0	0.0	0.1	-0.2	-0.0
Arm fat percentage (left)	0.0	0.1	0.3	-0.5	-0.2	-0.1
Loneliness, isolation	0.0	0.1	0.1	-0.3	-0.1	-0.3
Diabetes diagnosed by doctor	0.0	0.0	0.1	-0.2	-0.2	0.1
Number of operations (self-reported)	0.0	0.0	0.1	0.1	0.3	0.1

Hub : Genes

HGFAC

Models

Trait associations