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chr10:103,807,817-106,042,502

Best TWAS P=5.31e-14 · Best GWAS P=2.79e-15 conditioned to 0.152

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INA	0.21	0.31	lasso	2	0.30	6.9e-37	5.3	5.4	7.2e-08	-0.48	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NEURL	0.05	0.00	blup	417	0.02	7.9e-04	-5.9	6.0	2.0e-09	-0.55	0.10	0.12	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NT5C2	0.07	0.04	lasso	5	0.04	2.2e-05	5.9	7.3	3.5e-13	-0.76	0.07	0.93	FALSE
4	CommonMind	Brain Pre-frontal Cortex	USMG5	0.03	0.01	bslmm	352	0.00	7.5e-02	5.6	-6.7	2.8e-11	0.44	0.23	0.16	FALSE
5	GTEx	Adipose Subcutaneous	CALHM2	0.09	0.07	lasso	5	0.07	1.7e-06	5.9	6.9	5.0e-12	-0.62	0.06	0.94	FALSE
6	GTEx	Adipose Subcutaneous	MIR1307	0.53	0.52	enet	44	0.53	4.4e-51	5.6	5.6	2.4e-08	-0.46	0.69	0.31	FALSE
7	GTEx	Adipose Visceral Omentum	MIR1307	0.47	0.47	lasso	10	0.46	1.6e-26	5.6	5.6	2.0e-08	-0.43	0.65	0.35	FALSE
8	GTEx	Adrenal Gland	MIR1307	0.43	0.32	enet	20	0.36	1.1e-13	5.7	5.7	1.3e-08	-0.42	0.64	0.35	FALSE
9	GTEx	Artery Aorta	NT5C2	0.08	0.02	lasso	7	0.01	1.2e-01	-5.9	-6.1	9.7e-10	0.73	0.04	0.88	FALSE
10	GTEx	Artery Aorta	MIR1307	0.57	0.60	enet	27	0.62	2.3e-42	5.6	5.4	7.4e-08	-0.41	0.66	0.34	FALSE
11	GTEx	Artery Coronary	MIR1307	0.34	0.38	lasso	2	0.32	2.0e-11	5.7	5.7	1.4e-08	-0.42	0.66	0.34	FALSE
12	GTEx	Artery Tibial	MIR1307	0.44	0.53	lasso	8	0.54	2.3e-49	5.6	6.0	2.0e-09	-0.46	0.66	0.34	FALSE
13	GTEx	Brain Caudate basal ganglia	MIR1307	0.44	0.41	lasso	7	0.41	7.6e-13	5.6	5.3	9.6e-08	-0.44	0.65	0.35	FALSE
14	GTEx	Brain Cerebellar Hemisphere	MIR1307	0.41	0.48	lasso	4	0.46	2.2e-13	5.6	5.6	1.8e-08	-0.42	0.65	0.35	FALSE
15	GTEx	Brain Cerebellum	MIR1307	0.29	0.38	lasso	4	0.36	1.4e-11	5.6	5.6	1.8e-08	-0.42	0.66	0.34	FALSE
16	GTEx	Brain Cortex	MIR1307	0.40	0.46	enet	11	0.44	1.7e-13	5.6	5.8	5.9e-09	-0.44	0.65	0.35	FALSE
17	GTEx	Brain Frontal Cortex BA9	MIR1307	0.53	0.53	lasso	7	0.53	1.7e-16	5.6	5.8	8.5e-09	-0.46	0.65	0.35	FALSE
18	GTEx	Brain Hippocampus	MIR1307	0.39	0.47	lasso	5	0.46	3.9e-12	5.7	5.6	2.4e-08	-0.43	0.65	0.34	FALSE
19	GTEx	Brain Hypothalamus	MIR1307	0.42	0.48	lasso	6	0.45	7.4e-12	5.6	5.7	1.6e-08	-0.43	0.63	0.36	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	MIR1307	0.51	0.51	lasso	11	0.51	6.7e-16	5.7	6.0	2.4e-09	-0.47	0.65	0.35	FALSE
21	GTEx	Brain Putamen basal ganglia	MIR1307	0.57	0.44	lasso	9	0.45	4.2e-12	5.6	5.4	8.6e-08	-0.47	0.61	0.38	FALSE
22	GTEx	Breast Mammary Tissue	CALHM2	0.16	0.10	lasso	5	0.08	8.8e-05	5.6	5.8	7.7e-09	-0.47	0.43	0.28	FALSE
23	GTEx	Breast Mammary Tissue	MIR1307	0.32	0.41	lasso	6	0.41	2.0e-22	5.6	5.9	4.0e-09	-0.46	0.66	0.34	FALSE
24	GTEx	Breast Mammary Tissue	RP11-225H22.7	0.12	0.08	lasso	4	0.03	7.4e-03	5.6	6.3	3.1e-10	-0.46	0.26	0.18	FALSE
25	GTEx	Breast Mammary Tissue (Female)	MIR1307	0.36	0.40	lasso	4	0.40	4.7e-13	5.7	5.9	3.8e-09	-0.47	0.61	0.39	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	MIR1307	0.58	0.59	lasso	11	0.60	3.1e-24	5.6	5.9	2.7e-09	-0.48	0.65	0.35	FALSE
27	GTEx	Cells Transformed fibroblasts	CALHM2	0.12	0.12	enet	15	0.12	1.9e-09	5.5	6.9	5.9e-12	-0.54	0.62	0.38	FALSE
28	GTEx	Cells Transformed fibroblasts	MIR1307	0.59	0.61	enet	31	0.63	2.2e-60	5.6	5.3	1.1e-07	-0.40	0.66	0.34	FALSE
29	GTEx	Colon Sigmoid	MIR1307	0.60	0.56	lasso	10	0.54	2.1e-22	5.6	5.4	8.2e-08	-0.38	0.65	0.35	FALSE
30	GTEx	Colon Transverse	MIR1307	0.40	0.47	lasso	4	0.48	2.6e-25	5.7	6.0	2.3e-09	-0.47	0.63	0.37	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	MIR1307	0.33	0.44	lasso	6	0.44	1.1e-17	5.6	6.0	2.0e-09	-0.47	0.65	0.35	FALSE
32	GTEx	Esophagus Mucosa	MIR1307	0.45	0.54	lasso	4	0.53	2.9e-41	5.6	5.6	1.7e-08	-0.42	0.65	0.35	FALSE
33	GTEx	Esophagus Muscularis	MIR1307	0.52	0.50	enet	9	0.50	2.4e-34	5.7	5.9	3.3e-09	-0.46	0.66	0.34	FALSE
34	GTEx	Heart Atrial Appendage	MIR1307	0.61	0.62	enet	7	0.63	2.0e-35	5.7	5.2	2.4e-07	-0.37	0.65	0.35	FALSE
35	GTEx	Heart Left Ventricle	MIR1307	0.46	0.45	enet	23	0.46	1.3e-26	5.7	5.5	3.0e-08	-0.41	0.66	0.34	FALSE
36	GTEx	Liver	MIR1307	0.21	0.21	lasso	6	0.15	6.0e-05	5.7	5.8	6.6e-09	-0.45	0.35	0.30	FALSE
37	GTEx	Lung	MIR1307	0.44	0.49	enet	22	0.53	2.6e-47	5.6	5.5	3.8e-08	-0.46	0.65	0.35	FALSE
38	GTEx	Muscle Skeletal	MIR1307	0.61	0.62	enet	27	0.65	3.7e-83	5.7	5.6	2.4e-08	-0.45	0.66	0.34	FALSE
39	GTEx	Nerve Tibial	CALHM2	0.19	0.11	lasso	5	0.08	2.2e-06	5.8	5.7	9.9e-09	-0.42	0.41	0.56	FALSE
40	GTEx	Nerve Tibial	MIR1307	0.50	0.49	lasso	7	0.49	3.9e-39	5.7	5.8	5.8e-09	-0.44	0.66	0.34	FALSE
41	GTEx	Ovary	CALHM2	0.25	-0.01	enet	32	-0.01	4.9e-01	5.9	5.8	5.1e-09	-0.61	0.04	0.25	FALSE
42	GTEx	Ovary	MIR1307	0.33	0.43	lasso	4	0.42	1.8e-11	5.6	6.0	2.5e-09	-0.44	0.63	0.36	FALSE
43	GTEx	Pancreas	MIR1307	0.48	0.38	lasso	6	0.40	5.0e-18	5.7	6.4	2.1e-10	-0.49	0.62	0.38	FALSE
44	GTEx	Pituitary	MIR1307	0.56	0.58	lasso	5	0.59	4.1e-18	5.6	5.6	1.7e-08	-0.42	0.65	0.35	FALSE
45	GTEx	Prostate	MIR1307	0.42	0.45	lasso	2	0.41	1.8e-11	5.6	5.7	1.3e-08	-0.42	0.66	0.34	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	MIR1307	0.46	0.52	enet	23	0.52	4.4e-33	5.7	5.8	7.7e-09	-0.41	0.63	0.37	FALSE
47	GTEx	Skin Sun Exposed Lower leg	MIR1307	0.36	0.51	lasso	8	0.50	9.1e-48	5.6	5.8	7.1e-09	-0.45	0.64	0.36	FALSE
48	GTEx	Small Intestine Terminal Ileum	MIR1307	0.50	0.47	enet	21	0.45	1.9e-11	5.7	6.0	1.9e-09	-0.48	0.63	0.36	FALSE
49	GTEx	Spleen	MIR1307	0.53	0.57	enet	18	0.56	5.1e-17	5.6	5.5	4.9e-08	-0.46	0.64	0.36	FALSE
50	GTEx	Stomach	MIR1307	0.38	0.43	enet	13	0.46	1.7e-24	5.7	5.6	2.0e-08	-0.47	0.64	0.36	FALSE
51	GTEx	Testis	MIR1307	0.29	0.34	lasso	7	0.34	9.3e-16	5.7	5.5	3.2e-08	-0.48	0.64	0.36	FALSE
52	GTEx	Thyroid	MIR1307	0.52	0.57	lasso	5	0.57	1.2e-52	5.6	5.9	4.5e-09	-0.46	0.64	0.36	FALSE
53	GTEx	Vagina	MIR1307	0.36	0.40	enet	8	0.42	9.5e-11	5.7	5.8	7.8e-09	-0.44	0.61	0.38	FALSE
54	GTEx	Whole Blood	MIR1307	0.25	0.30	lasso	4	0.29	4.6e-27	5.6	5.7	1.1e-08	-0.43	0.65	0.35	FALSE
55	NTR	Blood	C10orf26	0.06	0.03	lasso	4	0.03	2.0e-09	-7.9	7.5	5.3e-14	-0.94	0.00	1.00	TRUE
56	ROSMAP	Brain Pre-frontal Cortex	CALHM2	0.05	0.05	lasso	3	0.04	5.0e-06	5.9	5.9	4.2e-09	-0.46	0.91	0.07	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	5.4	5.3	9.0e-08	-0.23	1.00	0.00	TRUE
58	ROSMAP	Brain Pre-frontal Cortex	USMG5	0.04	0.03	lasso	9	0.03	1.6e-04	5.6	-6.8	1.1e-11	0.41	0.66	0.03	FALSE
59	YFS	Blood	USMG5	0.50	0.71	lasso	4	0.71	0.0e+00	5.6	5.7	1.4e-08	-0.42	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	CALHM2	0.03	0.02	blup	49	0.02	3.0e-04	5.8	6.8	1.0e-11	-0.58	0.03	0.90	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	CALHM2	0.03	0.01	blup	49	0.01	2.9e-02	4.8	6.4	1.3e-10	-0.53	0.02	0.76	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	CALHM2	0.02	0.03	lasso	1	0.03	4.7e-04	5.6	5.6	2.5e-08	-0.46	0.07	0.64	FALSE