TWAS hub - CALHM2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0220	6.6e-03	0.001	0.006	0.005	0.009	0.001	2.3e-01	5.2e-02	6.9e-02	2.7e-02	2.5e-01
2	GTEx	Adipose Subcutaneous	0.0860	0.0300	5.8e-05	0.066	NA	0.060	NA	0.072	4.6e-06	NA	1.2e-05	NA	1.7e-06
3	GTEx	Breast Mammary Tissue	0.1580	0.0710	2.6e-03	0.104	NA	0.024	NA	0.077	5.6e-06	NA	2.0e-02	NA	8.8e-05
4	GTEx	Breast Mammary Tissue (Female)	0.0271	0.0707	3.8e-01	-0.005	NA	0.003	NA	-0.003	5.0e-01	NA	2.6e-01	NA	4.1e-01
5	GTEx	Cells Transformed fibroblasts	0.1210	0.0390	2.9e-06	0.115	NA	0.122	NA	0.114	6.3e-09	NA	1.9e-09	NA	7.0e-09
6	GTEx	Liver	0.1970	0.0790	2.9e-03	0.014	NA	0.081	NA	0.024	1.3e-01	NA	2.9e-03	NA	7.1e-02
7	GTEx	Nerve Tibial	0.1883	0.0728	1.9e-04	0.107	NA	0.047	NA	0.081	5.5e-08	NA	3.0e-04	NA	2.2e-06
8	GTEx	Ovary	0.2470	0.1020	5.8e-03	-0.012	NA	-0.006	NA	-0.011	8.4e-01	NA	4.9e-01	NA	7.2e-01
9	GTEx	Thyroid	0.0710	0.0350	9.7e-03	0.038	NA	0.059	NA	0.050	6.4e-04	NA	2.7e-05	NA	1.1e-04
10	GTEx	Whole Blood	0.1050	0.0500	5.1e-04	0.012	NA	0.026	NA	0.021	2.3e-02	NA	1.6e-03	NA	4.8e-03
11	METSIM	Adipose	0.0366	0.0165	6.2e-04	0.007	0.018	0.027	0.018	0.015	2.5e-02	8.6e-04	4.8e-05	9.4e-04	2.0e-03
12	ROSMAP	Brain Pre-frontal Cortex	0.0507	0.0178	9.0e-05	0.049	0.041	0.035	0.037	0.041	6.6e-07	5.2e-06	2.0e-05	1.2e-05	5.0e-06
13	YFS	Blood	0.1007	0.0303	1.6e-05	0.038	0.024	0.039	0.040	0.039	1.8e-12	1.6e-08	6.5e-13	3.7e-13	7.3e-13
14	TCGA	Breast Invasive Carcinoma	0.0268	0.0141	5.8e-04	0.018	0.015	0.013	NA	0.013	9.9e-05	3.0e-04	8.7e-04	NA	9.2e-04
15	TCGA	Head and Neck Squamous Cell Carcinoma	0.0355	0.0211	7.6e-03	0.006	0.008	0.003	NA	0.004	6.1e-02	3.7e-02	1.3e-01	NA	1.1e-01
16	TCGA	Brain Lower Grade Glioma	0.0298	0.0182	5.4e-03	0.011	0.009	0.004	NA	0.005	1.8e-02	2.9e-02	9.5e-02	NA	7.1e-02
17	TCGA	Lung Squamous Cell Carcinoma	0.0406	0.0219	4.8e-04	0.029	0.028	0.038	NA	0.037	2.5e-04	3.0e-04	3.4e-05	NA	4.4e-05
18	TCGA	Prostate Adenocarcinoma	0.0224	0.0138	7.3e-03	0.035	0.014	0.012	NA	0.029	1.4e-04	1.1e-02	1.7e-02	NA	4.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Birth weight	11.8	25.6	47.7	4.5	6.9	5.8	1.2	6.9	-4.0	5.7	5.8	5.0	2.9	3.7	5.9	0.2	6.8	3.0	6.4	4.3	5.6
Worry (Nagel 2018)	6.7	14.2	34.6	-4.1	-4.5	-3.8	-0.9	-4.3	1.4	-3.9	-4.9	-4.5	-2.4	-5.9	-3.6	-0.9	-4.4	-2.5	-4.2	-3.3	-3.8
Nervous feelings	5.4	10.1	20.7	-3.1	-3.6	-3.5	-2.0	-3.8	0.9	-2.8	-3.9	-4.0	-1.9	-4.5	-3.1	-1.4	-3.8	-2.2	-3.5	-3.1	-3.4
Worry too long after embarrassment	4.7	7.9	14.1	-3.0	-3.8	-3.2	-1.2	-3.7	1.1	-2.7	-3.4	-3.5	-1.3	-3.4	-2.7	-1.0	-3.6	-2.1	-2.8	-2.3	-2.9
Coronary Artery Disease (CAD)	4.4	5.2	10.8	-2.3	-2.5	-2.1	-0.4	-2.4	3.2	-1.5	-3.3	-2.2	-2.1	-2.8	-1.4	-2.3	-1.4	-1.7	-2.1	-3.3	-1.9
Illness, injury, bereavement, stress in last 2 years	4.4	5.4	9.9	2.8	2.2	2.9	1.6	2.5	2.4	2.9	1.5	2.4	-1.3	2.6	2.6	-0.1	1.7	3.1	1.9	2.4	2.7
Neuroticism	4.2	10.2	23.3	-3.9	-3.9	-3.5	-1.5	-3.8	0.1	-3.3	-3.8	-3.7	-1.0	-4.8	-3.4	-0.5	-3.6	-2.5	-3.3	-2.6	-3.3
Schizophrenia (2018)	4.1	8.5	25.6	-3.2	-3.3	-2.3	-2.8	-2.7	4.3	-2.4	-5.1	-3.3	-3.8	-4.0	-1.4	-0.2	-2.7	-0.9	-2.3	-1.4	-2.1
Age at first live birth	4.1	7.2	14.5	1.9	3.0	3.8	1.0	3.4	0.9	2.6	1.9	1.9	-3.0	1.4	3.1	0.9	2.4	3.5	2.8	3.8	3.6
Medication: Paracetamol	4.0	6.6	14.3	-1.7	-2.2	-3.2	-2.4	-2.8	0.3	-2.9	-3.1	-3.8	1.1	-2.2	-2.4	-2.2	-1.3	-3.3	-1.8	-3.4	-3.2
Serious illness, injury or assault to yourself	3.9	4.7	9.6	-2.4	-2.9	-2.5	-1.8	-2.9	-1.1	-2.0	-1.7	-2.5	-0.2	-3.1	-2.2	0.0	-2.2	-1.6	-2.5	-2.4	-2.2
Systolic blood pressure, automated reading	3.8	11.0	29.7	2.2	-5.5	-4.1	-3.8	-5.3	0.6	-3.3	-4.0	-2.3	-1.1	-2.0	-3.1	-0.8	-3.2	-1.9	-3.6	-3.9	-3.7
Financial difficulties in last 2 years	3.8	5.1	13.9	-1.2	-1.8	-2.9	-1.1	-2.4	-3.7	-2.1	0.2	-1.8	3.4	-2.0	-2.8	0.5	-1.7	-2.9	-1.9	-2.1	-2.8
Pulse wave reflection index	3.7	4.5	9.9	3.1	2.7	2.1	0.4	2.6	-3.1	1.5	2.3	2.2	1.3	1.8	2.2	-1.1	2.9	0.5	2.3	1.3	2.0
Medication: Co-codamol	3.6	4.2	7.9	-1.1	-2.5	-2.8	-0.2	-2.6	0.1	-2.5	-2.2	-2.6	1.1	-1.4	-2.7	0.3	-2.0	-2.1	-2.1	-2.0	-2.8
Lung cancer (father)	3.6	4.2	7.0	1.1	2.0	2.6	-0.5	2.4	-1.0	2.3	2.3	2.4	-0.6	1.9	2.5	1.1	2.2	2.4	2.5	2.3	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.5	9.4	-1.9	-2.5	-2.9	-2.4	-2.9	-1.3	-2.7	-2.1	-3.1	1.7	-2.7	-2.6	-0.6	-1.6	-2.3	-1.8	-2.6	-2.8
Age at last live birth	3.6	5.2	15.2	2.5	1.8	2.9	-0.3	2.5	0.3	1.6	1.5	1.1	-2.4	1.3	2.2	2.5	1.5	3.9	2.1	3.9	2.9
Average weekly spirits intake	3.5	4.3	10.2	-0.4	-3.2	-2.8	0.3	-2.8	0.3	-2.1	-1.5	-2.1	1.0	-1.2	-2.5	-0.9	-2.0	-2.5	-2.5	-2.7	-2.7
Systolic Blood Pressure	3.4	17.3	43.8	1.2	-5.9	-5.2	-4.0	-6.6	-0.4	-4.9	-4.9	-4.2	-1.1	-4.0	-4.2	-1.2	-3.8	-3.4	-4.2	-4.5	-4.7
Birth weight of first child	3.4	6.2	12.6	0.9	3.1	3.0	1.0	3.1	-2.0	2.7	3.3	2.4	2.3	-0.1	2.6	-0.5	3.5	1.4	3.4	2.7	2.9
Pack years adult smoking proportion	3.3	5.1	8.7	0.3	-2.6	-2.9	-1.5	-2.8	-2.1	-2.9	-1.3	-2.1	2.6	-1.5	-2.9	1.7	-2.4	-2.5	-2.0	-1.5	-2.7
Age at First Birth	3.1	4.5	9.8	-0.0	3.1	2.9	2.2	2.7	1.3	2.8	2.2	1.9	-0.6	1.0	2.5	0.8	1.7	2.3	2.1	2.2	2.7
Fractured/broken bones in last 5 years	3.1	4.0	8.5	-1.6	-2.6	-2.3	-1.7	-2.7	0.8	-1.7	-2.3	-2.2	-1.1	-2.9	-1.7	-1.2	-2.4	-1.2	-2.0	-1.9	-2.1
Impedance of leg (right)	3.0	14.6	29.7	-3.7	-4.2	-4.6	-2.6	-5.0	-0.6	-4.3	-3.7	-2.6	-1.6	-3.5	-4.7	-1.4	-5.4	-3.4	-5.0	-3.9	-4.4
Illnesses of father: High blood pressure	3.0	3.7	8.0	-0.1	-1.9	-2.4	-2.6	-1.8	-0.7	-2.8	-2.1	-2.6	1.1	-1.4	-2.2	0.2	-1.7	-2.2	-2.1	-1.5	-2.2
Bipolar Disorder or Schizophrenia	2.9	7.0	21.3	-2.4	-2.3	-2.0	-3.3	-2.1	3.6	-2.3	-4.6	-3.0	-3.7	-3.8	-1.2	-0.8	-2.3	-1.0	-2.1	-1.5	-1.8
Neuroticism (Nagel 2018)	2.9	6.8	19.7	-2.8	-3.5	-2.8	-1.1	-3.3	0.3	-2.6	-2.6	-3.1	-0.7	-4.4	-2.9	-0.6	-3.0	-1.7	-2.8	-1.9	-2.6
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.6	11.0	-1.9	-2.1	-2.4	-0.4	-1.4	1.1	-2.2	-3.3	-1.0	-0.4	-0.5	-2.1	-0.2	-2.0	-2.5	-2.3	-2.0	-2.5
Pack years of smoking	2.8	4.1	7.1	0.3	-2.4	-2.7	-1.9	-2.5	-1.8	-2.6	-1.1	-2.1	2.2	-1.3	-2.5	1.4	-2.0	-2.3	-1.7	-1.5	-2.5
Worrier / anxious feelings	2.7	5.1	15.0	-3.4	-1.9	-1.5	-0.5	-1.5	2.8	-2.3	-3.9	-3.1	-2.1	-3.3	-1.9	0.2	-1.8	-1.3	-2.2	-1.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.6	16.3	-4.0	-2.2	-2.9	-1.6	-2.8	0.7	-2.4	-1.7	-1.1	-0.6	-1.7	-2.5	-0.7	-3.0	-2.8	-3.0	-2.8	-2.7
Medication: Paracetamol	2.7	4.2	9.5	-1.9	-1.6	-2.6	-1.7	-2.4	0.5	-2.0	-2.3	-3.0	1.0	-1.7	-1.8	-1.6	-1.0	-2.6	-1.3	-3.1	-2.6
Heart disease (mother)	2.6	3.1	12.5	-3.5	-1.9	-1.6	0.3	-1.2	3.1	-1.2	-1.9	-0.4	-1.2	-0.7	-1.7	-1.6	-1.8	-1.2	-2.2	-1.3	-1.7
Schizophrenia (2014)	2.5	5.6	22.1	-2.0	-2.8	-1.8	-1.7	-1.9	4.0	-2.1	-4.7	-2.6	-3.1	-3.0	-1.1	-0.2	-1.7	-0.8	-1.7	-0.9	-1.6
Relative age voice broke	2.5	3.8	7.0	-1.2	-2.4	-2.3	-1.2	-2.3	-1.2	-2.6	-1.0	-2.3	1.5	-1.5	-2.6	2.1	-2.0	-1.6	-2.3	-1.3	-2.0
Mouth/teeth dental problems	2.4	3.8	16.7	-2.0	-1.3	-1.1	1.6	-1.2	4.1	-0.9	-3.4	0.2	-2.5	0.3	-1.4	-1.0	-2.6	-0.7	-2.6	-1.7	-1.3
Medication: Ibuprofen	2.4	2.9	6.9	-1.9	-1.9	-2.2	-0.1	-1.3	0.8	-1.9	-2.6	-0.8	0.2	-0.2	-2.0	-0.1	-1.8	-2.3	-2.1	-1.8	-2.3
Wheeze or whistling in the chest in last year	2.3	4.1	8.7	1.8	1.2	2.3	2.8	2.3	0.3	1.6	2.5	1.0	0.4	1.1	1.8	1.7	2.5	2.8	2.3	3.0	2.1
Had major operations	2.3	2.6	7.3	-0.5	-2.0	-2.1	-1.8	-2.0	-2.7	-1.3	-0.3	-1.2	0.8	-1.9	-1.7	-0.6	-1.8	-1.4	-1.6	-1.6	-1.9
Fasting Glucose	2.2	2.7	7.0	1.0	1.1	2.0	1.6	1.9	1.4	1.8	1.8	1.4	-1.4	1.1	1.4	-0.7	1.1	1.8	1.6	2.7	2.2
Impedance of leg (left)	2.2	10.6	21.7	-3.8	-3.5	-3.7	-2.5	-4.3	-0.8	-3.6	-2.9	-1.8	-1.6	-3.6	-3.8	-1.2	-4.7	-2.7	-4.2	-3.0	-3.5
Tense / ‘highly strung’	2.2	3.7	9.3	-0.5	-3.0	-2.2	-1.2	-2.7	-1.6	-2.5	-1.9	-0.8	-0.7	-2.9	-2.1	0.6	-2.6	-0.7	-2.3	-0.8	-1.9
Schizophrenia vs Biploar Disorder	2.1	2.8	9.1	-1.3	-3.0	-1.7	0.2	-2.2	1.5	-1.5	-2.7	-1.5	-1.4	-1.8	-1.4	1.4	-1.6	-0.2	-1.3	-1.2	-1.6
Alzheimer’s Disease (in father)	2.1	2.3	4.3	0.6	1.4	1.8	1.9	1.8	0.4	1.6	1.6	1.3	0.6	1.6	1.7	1.2	2.1	1.9	1.9	0.8	1.7
Ulcerative Colitis (UC)	2.1	3.9	9.5	1.4	2.7	2.2	0.1	2.2	-2.8	1.7	2.2	1.8	2.2	-0.2	2.1	-0.7	3.1	1.0	2.4	1.3	2.2
Smoking Status	2.1	5.0	42.1	3.7	-0.3	-0.7	-0.5	-0.6	-6.5	0.1	3.4	2.0	3.9	0.6	0.2	0.5	0.4	-0.4	1.2	0.4	0.1
Length of working week for main job	2.1	2.3	4.4	-1.1	-1.2	-1.9	-0.9	-1.7	-0.2	-1.9	-1.4	-2.1	1.0	-1.9	-1.6	-1.0	-1.3	-2.1	-1.3	-1.6	-1.9
Migraine (self-reported)	2.1	2.6	9.0	0.1	2.7	1.3	0.7	1.9	-0.4	1.9	2.0	2.2	3.0	2.0	1.2	0.1	1.7	0.2	1.8	0.2	1.1
Commuting to job workplace: Public transport	2.1	2.5	5.3	-1.7	-1.3	-1.6	-1.6	-1.5	0.4	-1.4	-2.3	-1.8	-0.8	-1.9	-1.5	-1.4	-1.8	-1.9	-1.8	-1.5	-1.6
Ever had prostate specific antigen (PSA) test	2.1	2.4	5.6	0.7	2.1	1.9	0.1	1.4	-0.2	2.4	2.2	1.5	-0.4	1.6	2.4	-0.8	2.0	1.4	1.6	0.2	1.7
Qualifications: CSEs or equivalent	2.0	2.6	6.5	1.7	2.0	1.6	0.2	2.1	0.6	2.2	1.7	0.4	0.1	-0.5	2.4	-1.9	2.5	0.9	2.0	0.6	1.7
Neuroticism score	2.0	4.1	10.8	-2.2	-2.6	-2.2	-0.9	-2.7	-0.7	-1.9	-2.2	-2.0	-0.3	-3.3	-2.4	0.0	-2.5	-1.4	-2.3	-1.5	-2.1
Time employed in main current job	2.0	2.3	5.6	0.8	2.1	1.9	-0.5	2.2	0.9	1.2	1.0	1.2	0.0	2.0	2.0	0.5	2.4	1.4	1.7	1.1	1.7
Neck or shoulder pain in last month	2.0	2.9	6.1	-1.3	-2.5	-2.2	-1.1	-2.1	0.4	-2.2	-1.7	-1.5	0.6	-1.6	-1.9	-0.8	-1.5	-1.9	-1.8	-1.7	-2.0
Average weekly champagne plus white wine intake	2.0	2.7	15.9	-2.3	1.5	1.6	2.2	1.0	-0.5	1.4	1.3	4.0	0.3	2.0	1.0	1.5	0.3	1.7	0.6	0.6	1.4
Impedance of whole body	2.0	10.1	21.8	-3.8	-3.2	-3.4	-1.9	-4.1	0.0	-3.4	-2.8	-2.4	-1.4	-3.4	-4.2	-1.3	-4.7	-2.4	-4.3	-2.9	-3.5
Ever highly irritable/argumentative for 2 days	1.9	2.2	7.8	-2.2	-0.6	-1.6	-0.7	-1.2	-1.4	-1.3	-1.1	-1.5	1.7	-1.1	-1.3	-1.3	-0.9	-2.8	-1.3	-1.8	-1.5
Qualifications: College or University degree	1.9	5.9	13.9	-3.5	-2.0	-2.2	0.1	-2.8	1.3	-2.4	-3.2	-1.6	-2.7	-2.0	-2.5	-0.6	-3.6	-1.2	-3.7	-2.3	-2.5
Medication for pain relief, constipation, heartburn	1.9	3.2	8.8	2.0	1.6	2.0	1.0	1.4	-1.9	1.9	3.0	2.4	-0.6	1.9	1.7	1.5	0.7	2.2	1.1	1.9	2.1
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	11.3	3.4	1.2	1.6	-0.6	1.3	-0.5	1.3	0.6	2.2	-0.7	0.8	1.8	0.2	1.7	1.1	1.5	0.7	1.5
Medication: Allopurinol	1.8	2.4	5.7	-1.9	-0.7	-1.5	-2.4	-1.5	-1.6	-1.4	-0.2	-1.1	0.9	-2.0	-1.5	-1.4	-1.1	-1.9	-1.4	-2.0	-1.4
Breast cancer (self-reported)	1.8	2.2	4.6	1.0	1.9	1.7	-0.3	1.9	-0.4	1.9	1.8	1.4	-0.1	0.1	1.7	-1.6	2.1	1.2	1.8	1.3	1.6
Financial situation satisfaction	1.8	2.3	9.1	-0.5	1.2	0.9	0.2	0.6	-2.6	1.4	2.6	-0.1	3.0	0.0	0.6	0.8	1.7	0.2	2.4	1.6	1.1
Eye problems/disorders: Glaucoma	1.8	2.2	7.1	-1.0	-1.9	-1.3	0.6	-1.7	0.8	-0.5	-1.0	0.1	-2.0	-1.6	-1.0	-1.9	-2.7	-0.0	-2.1	-1.8	-1.3
Average weekly beer plus cider intake	1.8	2.7	6.8	1.4	1.7	1.7	0.2	1.9	-0.3	1.4	1.6	0.3	1.7	2.1	1.6	1.4	2.6	0.4	2.3	2.2	1.7
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	7.2	1.6	1.3	1.2	-0.6	1.2	-2.2	0.6	2.7	0.3	2.0	0.3	1.0	1.7	1.6	1.0	1.8	1.9	1.2
Medication: Seretide 50 evohaler	1.7	2.0	6.0	1.1	1.0	1.4	0.7	1.3	0.9	1.3	1.6	0.5	0.8	1.4	1.0	1.7	1.6	1.9	1.8	2.5	1.5
Bipolar Disorder (2011)	1.6	1.5	6.1	-0.3	-0.8	-1.1	-2.5	-0.9	1.0	-1.5	-1.0	-0.5	-0.3	-0.8	-1.5	-1.0	-1.0	-1.8	-1.4	-1.7	-1.2
Crohns Disease (2012)	1.6	2.5	7.2	0.9	-2.7	-2.1	-0.6	-2.6	-1.9	-1.4	-0.5	-0.5	1.1	-1.2	-1.9	-1.0	-1.5	-1.2	-1.8	-1.3	-1.7
Alcohol usually taken with meals	1.6	2.6	7.2	-2.6	-1.0	-0.7	0.7	-1.2	2.3	-0.9	-1.5	-0.4	-2.6	-1.9	-1.2	-1.4	-2.7	-0.1	-2.1	-1.3	-0.9
Mouth/teeth dental problems: Dentures	1.6	2.7	17.3	1.7	1.0	0.6	-1.9	0.7	-4.2	1.1	3.1	0.6	1.3	-0.1	1.2	-0.3	1.6	0.3	1.9	0.8	1.0
Suffer from ‘nerves’	1.6	2.5	11.1	-2.8	-1.4	-1.3	-0.8	-1.4	-0.3	-0.9	-1.8	-2.1	-2.0	-3.3	-1.0	-0.4	-1.9	-0.5	-1.1	-0.6	-1.0
Leg fat-free mass (right)	1.6	8.8	21.1	1.7	3.3	2.7	2.4	3.4	-2.7	2.8	4.6	2.0	4.2	1.8	3.1	0.6	4.4	1.1	4.1	2.2	2.6
Leg predicted mass (right)	1.6	8.8	21.0	1.7	3.4	2.7	2.4	3.4	-2.7	2.8	4.6	2.0	4.1	1.7	3.1	0.6	4.4	1.1	4.1	2.2	2.6
HbA1C	1.5	1.6	5.0	1.5	0.8	1.5	1.4	1.5	0.4	1.9	0.8	0.9	-1.5	-0.1	0.3	-0.7	1.3	2.2	1.4	0.9	1.6
HDL Cholesterol	1.5	2.6	7.4	-2.0	-1.5	-1.6	-0.8	-1.7	2.1	-1.3	-2.4	-0.6	-1.2	-0.4	-1.5	0.0	-2.7	-1.5	-1.9	-1.1	-1.7
Chronotype (morning person)	1.5	3.5	17.5	-0.5	2.5	1.8	2.8	2.2	-0.3	1.3	2.2	4.2	0.4	3.1	1.4	0.0	1.1	0.6	0.5	0.5	1.3
Impedance of arm (right)	1.5	7.2	15.3	-3.8	-2.5	-2.7	-0.9	-3.3	0.3	-2.8	-2.2	-2.8	-0.9	-2.8	-3.9	-0.3	-3.9	-1.6	-3.7	-2.3	-2.9
Arm fat-free mass (right)	1.5	7.5	17.3	2.6	2.7	2.1	1.1	2.9	-3.7	2.5	4.2	2.4	3.7	1.2	3.2	-0.4	4.1	0.4	3.8	1.5	2.3
Whole body fat-free mass	1.5	8.3	21.1	1.8	3.2	2.3	1.6	3.1	-4.0	2.6	4.6	2.1	4.1	1.4	3.1	-0.1	4.3	0.4	3.9	1.4	2.3
Risk taking	1.5	2.2	7.0	1.3	-1.2	-1.6	-0.6	-1.5	-2.6	-2.1	0.1	-0.7	2.3	-0.3	-1.6	-1.0	-0.8	-2.0	-1.0	-1.3	-1.6
Diabetes (father)	1.4	1.8	3.9	-0.2	-1.6	-1.7	-1.0	-1.4	-1.3	-2.0	-1.1	-1.7	0.6	-0.8	-1.9	-0.3	-1.2	-1.3	-1.3	-1.3	-1.7
Number of incorrect matches in round	1.4	2.3	6.6	-2.1	-1.0	-1.0	-1.1	-1.2	2.3	-1.0	-2.0	-0.4	-2.4	-0.7	-1.0	-2.6	-1.4	-1.1	-1.4	-1.3	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	5.0	-1.1	-1.9	-1.8	-0.3	-2.2	-1.1	-1.5	-0.6	-1.1	0.8	-2.1	-1.9	0.8	-2.0	-0.8	-1.4	-1.1	-1.7
Trunk fat-free mass	1.4	8.2	24.7	1.6	3.2	2.0	0.9	2.9	-5.0	2.5	4.6	2.2	4.1	1.0	3.0	-0.6	4.1	0.0	3.8	1.0	2.1
Alcohol intake versus 10 years previously	1.4	2.2	7.7	0.9	-0.7	-1.2	-1.8	-1.3	-2.8	-0.2	2.0	-0.4	2.3	-1.7	-0.6	-2.4	-0.0	-1.5	0.0	-1.3	-0.9
Impedance of arm (left)	1.4	6.3	13.8	-2.9	-2.4	-2.6	-1.4	-3.2	-0.1	-2.7	-2.1	-2.6	-1.0	-2.7	-3.6	-0.9	-3.7	-1.5	-3.4	-2.0	-2.7
Trunk predicted mass	1.4	8.3	24.2	1.6	3.2	2.0	1.0	3.0	-4.9	2.6	4.7	2.2	4.1	1.0	3.0	-0.7	4.2	0.0	3.8	1.0	2.2
Arm predicted mass (right)	1.4	7.3	15.5	2.4	2.7	2.0	1.2	2.8	-3.7	2.4	3.9	2.6	3.9	1.5	3.0	-0.1	3.9	0.3	3.7	1.5	2.2
Family relationship satisfaction	1.4	1.7	3.8	-0.9	-1.7	-1.5	-0.9	-1.8	-0.5	-1.7	-0.6	-1.7	0.1	-2.0	-1.7	-0.4	-1.7	-1.3	-1.1	-0.3	-1.3
Whole body water mass	1.4	7.9	19.8	1.8	3.1	2.2	1.5	3.1	-3.8	2.6	4.5	2.1	4.0	1.5	3.0	-0.1	4.2	0.3	3.8	1.3	2.3
Ever depressed for a whole week	1.4	1.8	6.9	-2.0	-0.7	-1.3	-1.4	-1.1	0.5	-0.8	-0.7	-2.6	1.2	-1.0	-0.9	-1.9	-0.0	-1.7	-0.4	-1.5	-1.2
Major Depression (MDD)	1.3	1.6	3.9	-0.6	-1.6	-1.3	-1.3	-1.2	0.3	-1.5	-2.0	-1.0	-1.3	-1.7	-1.0	-1.1	-1.2	-0.9	-1.3	-0.7	-1.2
Type 2 Diabetes (T2D) (2012)	1.3	1.5	5.9	0.2	-1.1	-1.2	-2.0	-1.2	-0.5	-1.5	-1.5	-2.4	0.6	-0.3	-1.6	0.7	-1.1	-1.1	-1.0	0.3	-1.3
Leg fat-free mass (left)	1.3	6.7	17.4	1.8	2.8	2.1	2.2	3.0	-2.5	2.3	4.1	1.5	4.2	1.7	2.5	0.5	3.9	0.6	3.5	1.7	2.0
Medication: Atenolol	1.3	1.6	3.7	-1.1	-1.6	-1.5	0.1	-1.8	-0.8	-1.9	-1.1	-1.1	-0.4	-1.8	-1.4	-0.1	-1.5	-0.7	-1.3	-1.1	-1.5
Leg predicted mass (left)	1.3	6.7	16.9	1.8	2.8	2.1	2.1	3.0	-2.6	2.3	4.1	1.5	4.1	1.7	2.6	0.5	3.9	0.6	3.5	1.7	2.0
Heart attack	1.3	1.7	9.4	-1.1	-1.9	-1.4	-0.7	-1.4	0.2	-0.9	-1.7	-1.2	0.2	-3.1	-0.6	-0.2	-0.6	-0.0	-1.1	-1.8	-1.2
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	5.5	-2.3	-1.1	-1.7	-0.5	-1.2	-0.6	-1.3	-1.4	-1.2	0.6	-0.1	-1.6	1.1	-2.2	-2.0	-1.8	-1.5	-1.9
Angina (self-reported)	1.3	1.7	7.0	-2.3	-2.0	-1.4	0.6	-1.5	1.0	-1.2	-1.6	-0.4	-0.3	-2.6	-0.7	-0.6	-1.0	0.0	-1.0	-1.1	-1.1
Comparative height size at age 10	1.3	7.0	29.1	-0.7	3.3	1.8	0.1	2.1	-5.4	2.9	4.7	2.7	1.1	-0.0	2.8	-3.5	2.5	0.1	3.1	0.6	2.0
Supplements: Vitamin C	1.3	1.5	4.0	1.8	0.9	1.2	-0.4	1.2	-1.4	1.2	1.2	0.2	-0.4	-0.5	1.5	1.4	1.0	2.0	1.1	1.3	1.4
Illnesses of father: Heart disease	1.3	1.7	4.4	-1.5	-1.2	-1.3	-1.8	-0.8	2.1	-0.7	-1.3	-1.7	-1.2	-1.7	-0.3	-1.5	-0.3	-0.9	-0.7	-1.8	-1.2
Ever had bowel cancer screening	1.3	1.6	5.6	0.8	1.0	0.4	-2.4	0.7	-1.1	1.3	2.0	-1.0	1.6	-1.2	0.9	-1.4	1.4	-0.5	1.6	-0.4	0.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	5.3	0.5	1.6	1.5	1.2	1.6	-0.5	1.8	2.3	0.2	1.5	0.8	1.4	0.5	2.3	1.2	1.7	1.4	1.5
Smoking status: Current	1.3	2.1	18.1	2.5	-0.5	-0.7	-0.2	-0.5	-4.3	0.3	2.4	0.7	2.1	-0.5	-0.1	-0.4	0.2	-0.3	0.6	0.3	-0.3
Intelligence (Savage-Jansen 2018)	1.2	3.8	18.4	-0.3	2.6	2.5	2.4	2.3	-0.3	2.2	1.9	4.3	-0.5	1.1	1.3	-0.4	0.9	1.8	0.9	2.0	2.3
Hand grip strength (right)	1.2	3.3	12.2	0.6	-1.3	-2.2	-0.3	-1.6	-3.5	-1.6	0.2	0.6	1.9	-0.1	-1.6	-1.6	-1.4	-2.4	-1.9	-3.0	-2.4
Current tobacco smoking	1.2	1.9	18.7	1.8	-0.9	-1.2	-0.3	-1.0	-4.3	-0.2	1.9	0.4	1.8	-1.0	-0.4	-0.3	-0.4	-0.4	0.2	0.0	-0.7
Past tobacco smoking	1.2	2.1	14.4	-3.1	1.0	0.8	1.1	1.2	3.8	0.4	-1.8	-0.6	-2.3	-0.2	0.2	-0.6	0.5	0.0	-0.4	-0.1	0.1
High blood pressure (siblings)	1.2	1.7	6.3	2.5	0.6	0.7	-1.5	0.6	-0.1	1.6	1.4	-0.2	-0.2	-0.7	1.7	-2.5	1.8	0.5	1.4	-0.3	1.0
Illnesses of father: None of the above (group 1)	1.2	1.5	6.5	0.4	1.5	1.6	2.5	1.1	-0.2	1.3	1.2	2.2	-0.5	1.1	0.7	0.4	0.1	0.9	0.4	1.4	1.3
Ever smoked	1.2	2.1	11.3	2.1	-1.4	-1.4	-0.3	-1.6	-3.4	-1.2	0.9	0.2	2.6	-0.2	-1.3	0.9	-1.3	-0.8	-0.4	-0.3	-1.0
Basal metabolic rate	1.2	6.7	17.1	1.6	2.8	1.9	1.6	2.8	-3.5	2.2	4.1	1.9	4.1	1.4	2.6	0.2	3.9	0.3	3.5	1.3	2.0
Arm fat-free mass (left)	1.2	6.3	14.6	1.9	2.6	2.0	1.4	2.9	-3.1	2.3	3.7	2.3	3.5	1.3	2.9	0.2	3.8	0.4	3.5	1.3	2.1
Supplements: Calcium	1.2	1.4	8.0	0.2	-1.6	-0.8	-0.3	-1.0	-0.5	-1.0	-0.1	0.5	0.3	-0.5	-1.6	2.8	-1.9	0.6	-1.7	0.7	-0.6
Heart attack/myocardial infarction (self-reported)	1.2	1.5	7.7	-1.0	-1.9	-1.4	-0.6	-1.4	0.3	-0.9	-1.7	-1.1	0.5	-2.8	-0.7	-0.0	-0.4	0.0	-1.0	-1.6	-1.2
Arm predicted mass (left)	1.2	5.9	15.2	1.5	2.5	1.8	1.4	2.7	-3.0	2.2	3.9	2.0	3.7	1.1	2.7	-0.0	3.7	0.2	3.4	1.1	1.9
Lupus	1.1	1.7	5.7	-0.7	1.5	0.2	0.1	0.6	-2.3	1.3	1.6	0.1	2.4	-1.6	0.8	-2.1	1.2	-1.2	1.1	-0.9	0.3
Neuroticism (2016)	1.1	1.6	4.6	0.5	0.4	1.6	1.6	1.0	1.6	1.0	0.8	1.4	-1.0	0.6	1.4	0.4	0.9	2.1	1.1	1.9	1.8
Relative age of first facial hair	1.1	2.2	11.9	-0.9	-1.3	-1.5	-0.1	-2.0	-2.1	-1.1	1.0	-1.7	3.5	-0.3	-1.8	1.5	-0.7	-1.1	-0.6	-0.7	-1.2
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	6.1	-0.1	-1.0	-1.2	-1.2	-1.2	-0.1	-1.3	-0.3	-1.7	2.5	0.1	-1.0	-0.4	0.5	-1.4	-0.1	-1.3	-1.2
Glaucoma (self-reported)	1.1	1.3	4.6	0.8	-1.9	-0.9	0.5	-1.3	0.8	-0.6	-0.8	0.5	-2.0	-0.4	-0.6	-0.3	-2.1	0.6	-1.7	-0.8	-0.8
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.4	2.1	0.2	0.8	0.4	0.6	-0.4	0.9	1.8	0.3	0.4	0.6	0.7	1.4	1.0	1.8	1.5	1.7	1.0
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.6	1.6	1.3	0.5	-0.1	0.8	-1.5	0.6	1.4	1.3	1.8	1.9	0.5	0.8	0.8	0.2	0.9	0.8	0.6
Medication: Aspirin	1.1	1.4	4.0	0.3	1.0	1.4	0.5	1.3	1.4	1.0	0.5	1.1	0.2	0.3	1.6	-1.0	2.0	1.2	1.7	1.4	1.5
Pain type(s) experienced in last month: Hip pain	1.1	1.4	5.9	-0.7	-2.4	-1.7	-1.4	-2.0	-0.5	-1.1	-1.1	-0.1	-0.6	-0.2	-1.1	0.3	-1.7	-0.4	-1.1	-0.4	-1.3
Ovarian Cancer	1.0	1.4	5.2	-1.5	-1.1	-0.6	2.3	-0.8	1.8	-0.7	-1.4	-1.9	0.4	-1.1	-1.1	0.8	-0.8	-0.8	-0.8	0.2	-0.8
Hand grip strength (left)	1.0	2.6	14.9	1.4	0.0	-1.0	-0.2	-0.5	-3.9	-0.5	1.4	2.1	2.4	1.5	-0.4	-1.8	-0.1	-1.8	-0.6	-2.2	-1.3
Sensitivity / hurt feelings	1.0	1.8	4.7	-0.9	-2.1	-1.2	-1.1	-2.0	0.8	-0.9	-1.3	-1.2	-1.1	-2.2	-0.9	-1.5	-1.6	-0.4	-1.1	-1.1	-1.0
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.2	-1.5	-1.0	-1.2	-0.8	-1.5	-1.8	-1.0	-0.5	-0.1	1.1	-0.5	-1.7	1.3	-1.6	-0.9	-1.2	-0.6	-1.2
Hearing difficulty/problems: Yes	1.0	1.5	8.1	0.2	1.2	0.7	-2.8	0.1	-2.2	1.1	1.3	0.0	1.3	-1.0	0.8	0.3	1.0	1.1	1.6	0.9	0.9
Severe depression (siblings)	1.0	1.2	6.6	0.2	-1.2	-1.2	-2.6	-1.1	0.3	-1.3	-1.3	-1.2	0.2	-0.9	-0.8	0.6	-0.4	-0.7	-0.8	-1.1	-1.0
Maternal smoking around birth	1.0	1.5	7.4	1.3	-1.1	-1.2	-0.7	-0.9	-2.7	-1.3	0.9	0.5	2.1	-0.2	-0.7	-0.5	-0.3	-1.7	-0.7	-0.7	-1.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	4.2	1.0	0.3	0.5	0.2	0.2	-1.6	1.4	2.0	1.2	1.2	0.0	0.9	-0.3	0.9	1.3	1.3	0.3	0.9
Had other major operations	1.0	1.2	2.7	1.3	1.2	1.2	-1.0	1.1	-0.5	1.2	1.0	0.6	-0.7	-0.3	1.4	-0.5	0.9	1.3	1.3	1.6	1.5
Pulse rate	1.0	1.8	8.4	-2.4	-1.4	-0.8	-0.6	-1.7	2.4	-0.9	-0.2	-1.2	-0.5	-0.3	-1.0	2.9	-0.9	0.2	-0.8	-0.4	-0.9
Illnesses of mother	1.0	1.2	2.6	0.5	1.6	1.4	1.2	1.3	-0.3	1.1	0.9	0.9	0.7	1.4	1.0	0.4	1.6	0.7	1.6	0.4	1.1
Breastfed as a baby	1.0	1.2	5.7	-0.6	1.5	1.1	0.9	1.0	-0.5	1.3	0.9	0.8	-2.4	0.6	1.5	-0.6	0.7	0.6	1.0	0.8	1.4
Shortness of breath walking on level ground	1.0	1.2	2.6	-0.6	0.9	1.4	1.5	1.6	0.7	1.0	0.8	0.4	-0.3	0.0	1.1	0.7	1.5	1.2	1.2	1.5	1.4
Medication: Blood pressure	1.0	1.8	8.4	2.9	1.0	1.5	0.1	1.0	-0.1	0.8	0.7	0.9	-0.1	-0.1	1.3	-0.5	2.0	1.8	1.8	1.6	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	10.9	-1.7	0.2	-0.9	0.7	-0.6	-3.3	-0.4	1.5	-0.0	2.5	-1.4	-0.4	-1.6	0.1	-1.8	0.1	-1.8	-1.1
Eye problems/disorders: Cataract	1.0	1.1	7.8	-2.8	0.0	-0.8	-0.8	-0.8	0.4	0.5	0.4	-1.1	0.4	0.1	-0.2	-1.4	-0.6	-1.9	-0.3	-1.3	-0.8
Back pain experienced in last month	1.0	1.5	11.6	1.4	-1.4	-1.1	-0.4	-0.9	-3.4	-1.4	0.0	-0.5	0.6	-1.3	-0.9	1.4	-0.6	-0.4	-0.6	-0.1	-0.8
Medication: Blood pressure	1.0	2.0	5.4	1.1	-2.0	-1.7	-1.4	-2.3	-0.3	-1.3	-0.7	-1.7	0.5	-1.6	-1.1	-1.2	-0.8	-1.5	-1.0	-1.9	-1.4
Irritability	1.0	1.7	10.5	-0.4	-1.2	-1.1	0.2	-1.1	-2.8	-1.6	0.3	0.9	3.2	-0.7	-1.3	0.5	-0.1	-0.7	-0.6	-0.6	-1.0
Depression (Nagel 2018)	0.9	1.3	3.0	-1.1	-1.5	-1.4	-0.6	-1.7	-1.2	-0.8	0.1	-0.9	1.2	-1.6	-1.5	0.5	-1.2	-0.8	-1.0	-1.1	-1.3
Irritable Bowel Disease (IBD)	0.9	2.2	5.7	2.1	1.3	1.3	-0.1	1.3	-2.0	1.4	1.8	1.3	1.5	-0.3	1.6	-0.7	2.4	1.0	1.8	0.8	1.6
Prostate Cancer	0.9	1.2	6.7	-0.5	-0.3	-0.6	-0.8	-0.6	1.2	0.1	-0.8	-0.8	-2.6	-1.4	-0.6	-1.7	-1.4	-1.1	-1.1	-1.0	-0.8
Mean Putamen Volume	0.9	1.0	2.9	-0.2	0.6	1.1	-0.1	0.6	-1.1	1.0	1.7	-0.4	0.4	-1.2	1.1	-0.7	1.4	1.0	1.5	1.4	1.1
Ulcerative Colitis	0.9	1.3	8.5	0.2	1.1	0.4	-1.3	0.5	-2.9	-0.2	0.6	0.3	2.4	-0.9	0.5	-0.8	1.4	-0.5	1.0	0.4	0.7
Height	0.9	17.7	151.3	-2.9	3.7	0.7	0.0	1.2	-12.3	2.4	7.7	1.5	5.3	-3.9	1.5	-3.8	2.1	-1.7	2.4	-1.4	1.1
Lung FVC	0.9	4.6	16.0	-3.4	-2.3	-2.6	-1.3	-2.3	1.6	-1.5	-2.0	-1.9	-1.1	-4.0	-1.6	-1.8	-1.7	-1.7	-1.6	-2.2	-2.1
Angina	0.9	1.2	5.5	-2.1	-1.6	-1.1	0.7	-1.2	0.7	-1.0	-1.2	-0.2	-0.1	-2.4	-0.5	-0.7	-0.7	0.1	-0.8	-0.8	-0.9
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.4	0.5	1.2	1.5	1.6	1.2	0.5	1.2	1.3	0.4	0.5	0.7	0.7	-1.0	1.0	0.7	0.9	1.5	1.5
Falls in the last year	0.9	1.2	7.8	0.0	-1.5	-1.0	-0.4	-1.4	-1.7	-0.9	-0.1	-1.0	1.5	-2.8	-0.9	-0.2	-0.2	0.1	-0.5	-0.5	-0.7
Noisy workplace	0.9	1.2	2.2	1.5	0.8	0.8	-1.2	0.8	-1.2	1.3	1.5	1.1	0.2	0.8	1.5	-1.3	1.1	-0.1	1.3	0.3	1.0
Standing height	0.9	8.7	65.4	-1.8	2.7	0.5	0.2	0.9	-8.1	1.6	5.4	1.4	4.7	-2.0	1.1	-2.5	2.0	-1.4	2.2	-0.6	0.7
Exposure to tobacco smoke at home	0.9	1.0	2.2	-0.9	-0.7	-1.0	-1.4	-0.7	-1.3	-1.3	-0.9	-0.8	0.5	-0.5	-1.4	1.5	-0.8	-0.7	-1.0	0.0	-1.1
Knee pain experienced in last month	0.9	1.4	7.6	2.8	0.3	0.7	-0.2	0.3	-1.6	0.4	1.0	1.7	-0.4	2.1	1.1	1.0	0.5	1.1	0.9	0.5	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	4.7	0.3	-0.3	0.8	1.2	-0.1	1.2	0.5	-0.1	0.1	-1.1	0.3	0.2	0.6	-0.4	2.2	0.5	2.0	1.2
Age started oral contraceptive pill	0.9	1.1	2.5	1.2	1.0	1.2	-1.0	1.1	1.3	1.2	0.9	-0.0	-1.0	-0.1	1.6	-0.1	1.1	0.9	1.2	0.9	1.6
Unable to work because of sickness or disability	0.9	1.2	7.8	0.2	0.9	-0.2	-0.8	-0.4	-2.8	0.2	2.0	-0.8	2.1	-0.3	0.4	-0.2	0.6	-0.8	1.0	-0.4	-0.0
Primary Biliary Cirrhosis	0.8	1.1	3.2	0.2	-1.6	-1.3	-0.2	-1.4	1.0	-1.0	-1.8	-0.8	0.0	-0.5	-1.2	0.1	-1.5	-0.6	-1.5	-0.8	-1.1
Blood White Count	0.8	6.1	24.1	1.2	-2.4	-2.6	-3.6	-3.3	-4.9	-2.7	-0.0	-3.1	3.7	-2.0	-1.9	-0.6	0.1	-1.9	0.1	-1.4	-2.1
Medication for hormone replacement therapy	0.8	0.9	7.6	0.0	0.3	-0.6	0.6	-0.3	-1.4	-0.1	0.6	0.1	2.8	0.9	-0.5	0.1	0.4	-1.4	-0.1	-1.5	-0.8
Townsend deprivation index at recruitment	0.8	1.1	6.4	0.2	-0.7	-1.1	0.3	-0.8	-2.1	-1.2	0.1	-0.8	2.5	-0.4	-1.0	-0.0	-0.2	-1.4	-0.3	-0.0	-1.1
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	6.4	-0.1	-0.7	-0.7	0.0	-0.5	2.5	0.2	-1.3	-0.1	-0.9	-0.3	-0.6	-0.5	-0.9	-0.3	-1.4	-1.6	-0.9
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.6	-0.5	-0.5	-1.0	-1.4	-0.6	-1.5	-1.1	-0.7	-0.8	1.6	-0.6	-0.7	-0.8	0.2	-1.6	-0.1	-0.9	-0.9
Medication: Ramipril	0.8	1.0	6.5	1.4	0.1	0.6	-0.8	-0.0	1.1	0.4	-0.4	-0.7	-2.6	-1.1	0.9	-1.7	0.2	1.1	0.4	0.4	0.8
Illnesses of siblings	0.8	1.1	5.2	-1.4	-0.2	-0.1	0.8	-0.3	0.1	-1.2	-1.6	0.4	-0.6	0.8	-1.3	2.3	-1.7	-0.3	-1.2	1.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	6.5	-2.4	-1.0	-2.0	-0.7	-1.8	-2.1	-1.2	0.5	-1.3	1.1	-2.5	-1.2	-1.1	-0.9	-2.4	-0.7	-2.4	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	7.2	-2.3	-1.0	-2.1	-0.2	-1.7	-1.9	-1.3	0.1	-1.0	1.6	-1.8	-1.4	-0.7	-0.9	-2.7	-1.0	-2.5	-2.0
Pulse wave Arterial Stiffness index	0.8	0.9	5.6	0.9	0.2	1.0	-0.9	0.5	1.4	0.1	-0.2	-0.1	-2.4	-0.2	0.9	-0.2	0.9	1.3	0.6	1.0	1.0
Headache pain in last month	0.8	1.4	6.0	0.5	0.3	-1.1	-0.9	-0.0	-1.2	-0.8	-0.3	-0.6	2.5	-0.6	-1.1	-1.1	0.4	-2.4	-0.7	-1.8	-1.3
Forced vital capacity (FVC), Best measure	0.8	2.8	7.2	-2.6	-0.7	-2.0	-0.1	-1.5	-2.4	-0.9	0.3	-0.6	1.7	-2.5	-1.0	-1.3	-0.8	-2.7	-0.7	-2.4	-1.8
Number of children fathered	0.8	0.9	2.8	0.1	-0.8	-1.0	-1.7	-0.7	0.3	-1.2	-1.6	-0.2	0.1	0.5	-1.1	0.0	-1.5	-0.6	-1.4	-0.5	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.0	-0.1	1.0	0.9	-0.6	0.1	-0.3	0.8	1.5	-0.5	0.8	0.2	0.7	-1.4	1.0	0.8	1.7	1.5	1.2
Pulse wave peak to peak time	0.8	1.0	6.5	-1.0	0.1	-0.8	0.8	-0.4	-1.9	0.1	0.7	0.3	2.5	0.3	-0.7	0.0	-0.7	-1.3	-0.4	-1.0	-0.8
Health satisfaction	0.8	1.1	3.2	-1.5	-1.2	-1.0	-1.0	-1.3	-0.3	-0.9	-0.1	-1.8	0.9	-1.5	-1.1	-1.1	-0.6	-1.2	-0.4	-0.4	-0.8
Eye problems/disorders: None of the above	0.8	1.0	4.9	2.2	-0.1	0.5	1.5	0.4	-0.1	-0.9	-0.5	1.1	-0.6	1.0	-0.1	2.2	0.2	0.9	-0.0	0.7	0.3
Pulse rate, automated reading	0.8	2.7	11.0	-3.3	-1.7	-1.3	-1.3	-2.2	2.9	-1.5	-0.9	-1.0	0.7	-0.1	-1.9	1.4	-1.2	-1.2	-1.4	-1.0	-1.4
Alcohol intake frequency.	0.8	1.8	7.3	-1.8	-0.8	-1.3	-1.0	-1.3	0.1	-0.4	-0.0	-1.1	0.5	-2.7	-0.5	-2.7	-0.5	-1.3	-0.5	-1.8	-1.2
Number of full sisters	0.8	1.0	3.3	-1.8	-0.5	-0.8	1.6	-0.4	0.0	-0.6	-0.8	-0.4	1.2	-1.4	-1.0	-1.8	-0.4	-0.9	-0.7	-0.5	-0.7
Osteoarthritis (self-reported)	0.8	1.1	2.8	-0.2	-1.0	-1.3	-1.6	-1.2	0.1	-1.0	-1.4	-1.6	-0.6	-0.8	-0.5	-0.5	-0.2	-0.9	-0.6	-1.7	-1.1
Myopia	0.8	1.2	5.2	-1.1	0.3	1.0	1.6	0.5	2.3	0.9	0.4	-0.0	-1.1	0.8	0.9	1.4	0.7	1.3	0.6	1.2	1.1
Blood Red Count	0.7	6.5	22.8	4.3	3.6	1.6	-1.7	1.8	-4.8	1.7	3.4	1.2	0.9	0.1	2.6	-3.3	2.8	-1.2	2.7	-0.3	1.6
Vitamin and mineral supplements	0.7	0.9	9.6	-1.5	0.2	0.1	0.4	0.5	3.1	0.0	-1.4	-0.3	-0.1	1.0	-0.3	-0.6	0.6	-0.8	0.1	0.1	-0.1
Supplements: Zinc	0.7	0.7	6.3	0.7	-0.4	-0.7	-0.4	-0.5	-2.5	-0.3	0.7	0.9	1.0	0.2	-0.6	0.3	-0.6	-0.6	-0.5	-0.7	-0.8
High blood pressure	0.7	2.0	5.9	2.4	-2.0	-1.3	-2.4	-2.2	-0.8	-0.9	-0.1	-0.6	0.6	-1.8	-0.6	-2.2	0.2	-0.9	-0.3	-1.4	-1.0
Hearing difficulty/problems with background noise	0.7	1.1	11.0	0.0	0.6	-0.0	-1.8	-0.5	-3.3	-0.2	0.6	-0.1	1.6	-1.2	-0.1	0.0	0.1	0.1	0.7	0.3	0.0
Forced vital capacity (FVC)	0.7	2.7	9.8	-2.3	-0.7	-1.8	-0.6	-1.6	-2.9	-0.7	0.8	-0.8	1.3	-3.1	-0.8	-1.7	-0.6	-2.2	-0.2	-2.3	-1.4
Number of live births	0.7	0.9	4.0	0.2	-1.6	-0.6	-1.5	-0.9	1.0	-0.4	-2.0	-0.4	-1.4	0.1	-0.4	0.3	-1.2	0.6	-1.1	-0.4	-0.4
Depression (self-reported)	0.7	0.9	3.9	-0.3	0.8	0.8	-1.3	0.5	-1.0	0.8	1.4	-0.5	-0.5	-2.0	0.7	-0.3	0.7	0.9	1.1	0.8	1.0
Prospective memory result	0.7	0.8	2.5	0.7	0.3	0.9	0.6	0.4	1.1	0.9	1.6	-0.4	-0.9	0.3	1.0	-0.4	1.0	1.1	1.1	1.2	1.1
Peak expiratory flow (PEF)	0.7	1.5	8.4	-1.3	-0.8	-1.3	-0.3	-1.1	-2.9	-1.2	1.0	-0.2	1.6	-1.4	-0.9	-0.6	-0.2	-1.7	-0.3	-1.3	-1.1
Mean time to correctly identify matches	0.7	1.4	4.9	0.1	-0.1	0.8	-1.3	0.7	0.7	1.1	-0.1	-1.0	-2.2	-0.7	1.0	1.8	0.5	2.2	0.9	1.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	7.1	0.9	-0.3	-0.5	-0.2	-0.5	-2.7	-0.4	0.5	-0.2	1.7	0.2	-1.1	0.5	0.1	-0.7	0.2	0.3	-0.4
Hypertension (Self-reported)	0.7	1.9	5.3	2.3	-2.0	-1.5	-2.2	-2.3	-0.5	-1.3	-0.4	-0.7	0.6	-1.5	-0.9	-1.4	-0.3	-0.9	-0.7	-1.4	-1.2
Illnesses of siblings: Diabetes	0.7	0.8	2.6	-0.4	0.9	0.7	0.3	1.1	1.6	1.2	0.5	0.5	1.5	0.8	0.4	-1.5	1.2	0.0	0.8	0.1	0.4
Smoking status: Previous	0.7	1.0	7.7	1.9	-0.8	-0.7	-1.1	-1.1	-2.8	-0.5	0.7	0.5	1.1	0.1	-0.2	0.1	-0.8	-0.1	-0.0	-0.1	-0.1
Qualifications: nursing, teaching	0.7	1.2	6.7	-1.4	-0.8	-0.4	0.6	-1.0	0.5	0.1	-0.6	0.4	-2.6	-1.0	-0.1	-1.9	-1.5	0.7	-1.2	-0.6	-0.4
Commuting to job workplace: Walk	0.7	0.8	5.2	0.3	0.0	0.2	-0.3	0.0	-0.1	0.6	-0.3	-0.4	-2.0	-2.3	0.6	-1.8	0.0	0.7	-0.1	-0.0	0.3
Medication: Aspirin	0.7	0.9	2.9	0.0	0.7	0.9	-0.2	0.8	1.2	0.8	0.4	0.7	0.2	-0.2	1.4	-1.5	1.7	0.7	1.3	0.6	1.1
Wears glasses or contact lenses	0.7	0.8	2.5	-0.1	0.6	1.0	-0.8	0.7	0.4	1.0	0.9	0.3	-1.6	-0.4	1.3	-0.8	0.8	0.8	1.1	0.5	1.2
Hearing aid user	0.7	0.8	2.9	-0.4	0.2	-0.9	-1.7	-0.7	-1.1	-0.7	-0.5	-0.1	1.4	0.2	-0.5	-0.9	-0.4	-1.3	-0.1	-1.2	-1.1
Medication: Bendroflumethiazide	0.7	1.1	8.2	2.9	-0.4	0.0	-1.1	-1.1	-1.7	0.1	1.4	-0.7	1.1	-0.5	0.5	-0.1	1.2	0.5	0.9	-0.1	0.3
Alcohol drinker status: Never	0.7	0.8	3.0	-0.8	0.7	1.0	1.1	1.1	0.9	0.5	-0.2	1.3	-1.7	0.4	0.7	-0.3	0.5	0.9	0.6	1.0	1.0
Diastolic blood pressure, automated reading	0.7	2.3	15.2	3.9	-1.1	-0.7	-2.3	-1.3	-2.4	-0.7	0.7	1.1	1.1	0.7	0.8	-0.9	1.8	-0.0	0.9	-1.2	-0.3
Alzheimer’s Disease (including proxy)	0.6	0.8	4.2	0.2	0.7	0.9	0.5	1.0	0.1	0.3	0.3	-0.7	1.3	-0.2	0.5	2.0	0.8	1.1	0.9	1.1	0.9
Breast Cancer	0.6	1.4	7.1	-0.9	0.6	1.0	1.5	1.0	2.7	0.8	-0.3	-0.9	-1.8	-1.0	0.7	-1.7	0.9	0.5	0.9	0.7	0.9
Triglycerides	0.6	1.0	4.8	1.2	0.8	0.2	-0.9	0.8	-2.2	0.4	0.4	-0.8	0.3	-1.7	0.6	-1.8	1.3	-0.6	0.5	-0.9	0.2
Cardiovascular Disease	0.6	1.9	5.5	1.3	-1.9	-1.8	-1.6	-2.3	0.1	-1.8	-1.1	-1.9	1.1	-1.4	-1.0	-0.9	0.1	-1.3	-0.4	-1.2	-1.4
Taking other prescription medications	0.6	0.9	2.3	0.1	0.7	1.2	-0.2	1.0	0.3	1.0	1.0	1.4	0.2	-0.0	1.0	-0.6	1.0	1.4	1.2	1.5	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.2	-2.0	-0.2	-0.7	-1.0	-0.6	0.6	-0.8	-1.9	-1.3	-1.0	-1.1	-0.5	-1.8	-1.1	-1.6	-0.9	-0.9	-1.0
Supplements: Glucosamine	0.6	0.7	1.7	-0.0	-1.1	-1.0	-1.2	-1.2	-1.2	-0.8	-0.2	0.5	-0.3	0.1	-0.6	-0.2	-1.0	-0.8	-1.3	-1.1	-0.9
High blood pressure (mother)	0.6	0.9	4.5	0.9	-1.3	-0.7	-1.4	-1.0	-0.1	-0.2	-0.5	-0.6	-2.1	-1.8	0.3	-1.0	-0.6	0.3	-0.7	-0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	4.6	-2.1	0.3	-0.8	-1.4	-0.4	-0.2	-1.0	-1.9	-1.4	-0.0	-0.7	-0.5	-1.9	-0.6	-2.1	-0.6	-1.3	-1.1
Father’s age at death	0.6	0.8	3.3	-0.4	-0.6	-0.1	1.5	-0.6	0.6	-0.5	-0.9	0.3	-1.8	0.5	-0.6	0.9	-1.6	0.7	-1.2	0.7	-0.2
Happiness	0.6	0.8	3.9	-1.4	-0.9	-0.6	-0.4	-0.6	0.6	-0.5	-1.0	-1.2	-0.6	-2.0	-0.8	-0.6	-0.6	-0.7	-0.6	-0.5	-0.4
Medication: Amlodipine	0.6	0.8	2.8	1.0	-1.2	-0.6	-0.5	-1.2	0.0	-1.4	-0.8	-0.2	0.5	0.5	-1.7	0.5	-1.1	-0.2	-1.3	0.1	-0.8
Exposure to tobacco smoke outside home	0.6	0.9	4.4	0.1	-0.7	-0.9	1.2	-0.8	-2.1	-1.0	0.8	0.5	1.5	-0.3	-1.0	-0.4	-0.4	-1.1	-0.2	-0.6	-0.8
Comparative body size at age 10	0.6	1.6	4.7	0.1	-2.2	-1.3	-1.0	-1.8	1.4	-1.0	-1.7	-1.5	-0.7	-0.6	-1.4	0.7	-1.9	0.3	-1.4	-0.0	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	6.8	2.6	-0.4	0.3	-0.2	0.1	0.2	0.1	0.5	-0.0	-0.4	0.0	0.4	-0.4	0.4	1.1	1.0	1.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.5	0.6	-1.0	-1.1	-1.0	-0.5	0.3	-1.6	-0.9	-0.5	-0.2	-0.5	-0.9	-0.2	-0.2	-1.3	-0.7	-1.1	-1.2
Mood swings	0.6	1.2	6.6	-0.5	0.5	1.0	0.4	1.0	0.1	0.6	0.6	0.6	-0.1	1.0	0.1	2.6	0.1	1.5	0.6	2.4	1.1
Mineral and other dietary supplements	0.6	0.8	9.3	-1.2	0.6	0.2	1.2	0.2	3.0	0.3	-0.8	-0.7	-0.4	0.3	0.3	-0.4	0.2	0.0	0.6	0.2	0.2
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.7	-1.8	2.2	1.2	2.1	2.1	0.1	0.8	0.1	0.3	-0.0	2.0	0.3	2.1	-0.2	0.4	0.2	1.2	0.7
Alzheimer’s Disease (in mother)	0.5	0.6	2.4	0.6	0.2	0.4	-0.7	0.3	-0.3	-0.1	-0.1	-1.5	0.6	-1.5	-0.1	1.5	0.1	0.6	0.2	0.9	0.5
Blood Platelet Count	0.5	5.4	25.6	3.2	0.9	0.2	-4.0	-0.4	-4.4	0.3	3.3	-0.8	5.1	1.7	0.1	0.3	2.3	-0.6	2.0	0.3	0.4
Hypothyroidism (self reported)	0.5	1.2	4.2	1.6	0.5	0.7	-0.6	0.8	0.6	0.7	0.0	1.3	-0.5	2.0	1.0	-1.9	1.6	0.4	1.4	0.7	0.7
Pain all over the body in last month	0.5	0.6	3.1	-1.5	0.3	-0.3	-1.3	0.0	0.5	0.2	0.6	-0.7	0.2	-0.9	0.3	-1.7	-0.1	-0.8	0.1	-0.6	-0.2
Fluid intelligence score	0.5	1.0	5.5	-2.3	0.6	-0.2	1.3	-0.1	0.6	-0.2	-0.3	1.3	0.9	0.8	-1.0	-1.2	-0.7	-1.3	-1.1	-1.0	-0.6
Weight	0.5	2.5	12.4	1.2	1.0	0.7	1.0	1.4	-2.3	0.8	2.7	1.1	3.5	1.1	1.2	0.5	2.3	-0.3	2.0	0.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	4.2	-0.9	0.0	-0.1	1.3	-0.0	-0.8	-0.3	1.0	0.3	2.0	0.5	-0.3	2.0	0.2	0.6	0.3	1.0	0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.0	4.9	-2.2	-0.2	-0.4	1.4	-1.2	0.4	-0.4	-0.7	-0.7	-0.9	0.2	-1.2	-0.7	-1.8	0.0	-1.4	-0.2	-0.7
Medication: Cholesterol lowering	0.5	0.7	1.6	1.2	0.6	0.9	0.2	0.9	0.9	0.8	0.8	0.8	-0.2	-0.3	0.7	-0.9	1.2	1.2	0.8	0.8	0.9
Medication: Lansoprazole	0.5	0.6	2.0	-1.0	-0.2	-0.6	-0.5	-0.1	0.5	-1.0	-0.1	-1.1	0.8	0.1	-0.5	-0.2	0.9	-1.4	0.1	-1.4	-0.8
Loud music exposure frequency	0.5	0.6	2.3	-0.2	-0.9	-0.9	-0.4	-0.6	0.0	-0.6	-0.0	0.0	-0.2	-0.6	-1.1	-0.5	-1.5	-1.2	-1.2	-0.3	-0.8
Blood clot in the leg (DVT)	0.5	0.7	2.3	-1.4	-0.8	-0.6	-0.4	-0.2	0.7	-1.1	-1.5	-1.0	-0.2	-0.1	-0.9	1.2	-0.5	0.2	-0.8	-0.1	-0.6
Gout (self-reported)	0.5	0.7	2.2	-0.7	1.1	0.3	-1.5	0.2	-1.3	0.0	1.2	0.3	1.1	-0.7	0.2	-1.5	0.4	-0.6	0.4	-0.5	0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	6.7	1.1	0.6	0.7	-0.3	0.9	1.3	0.4	-0.4	1.2	-0.2	2.6	0.8	-0.7	1.5	0.3	1.3	0.7	0.6
Emphysema/chronic bronchitis	0.5	0.5	2.2	-0.2	-1.5	-0.7	0.3	-0.9	0.8	-0.7	-0.1	-0.7	-0.1	-0.6	-1.0	0.4	-1.0	-0.7	-0.9	-0.1	-0.6
Average weekly red wine intake	0.5	0.8	2.6	0.6	-1.0	-0.3	0.3	-0.5	1.4	-0.9	-1.6	-0.3	-1.6	-0.9	-0.8	-0.4	-1.1	0.8	-0.9	0.1	-0.4
Osteoporosis (self-reported)	0.5	0.6	2.2	0.4	-0.3	0.1	-1.5	-0.3	-0.5	0.8	0.6	0.2	-1.0	-1.4	0.7	1.1	-0.1	1.1	0.3	0.6	0.4
Number of operations (self-reported)	0.5	0.8	8.3	-0.1	0.1	-0.2	-2.9	-0.3	-2.1	-0.3	-0.3	-0.4	-0.2	-0.7	-0.2	-0.5	-0.2	-0.6	-0.1	-0.2	-0.2
Basal cell carcinoma (self-reported)	0.5	0.6	2.3	0.2	1.0	0.8	-0.0	0.6	-0.9	0.6	0.5	1.5	-0.2	1.2	0.8	-0.4	0.5	0.5	1.0	0.5	0.7
Alcohol drinker status: Previous	0.5	0.6	2.0	-0.4	0.4	0.6	-0.5	-0.0	1.0	0.9	0.4	-0.6	-0.6	-1.4	1.0	-1.4	0.7	0.7	1.0	0.5	0.7
Bipolar Disorder (2018)	0.4	0.6	3.4	0.2	0.4	-0.2	-1.8	-0.0	0.4	-0.6	-1.4	-0.8	-1.1	-1.1	-0.2	-1.1	-0.4	-0.5	-0.6	-0.7	-0.3
Reaction Time	0.4	0.8	3.9	-0.7	-0.6	0.0	-0.7	0.1	1.4	0.3	-0.7	-1.4	-1.4	-0.6	0.3	2.0	-0.0	1.3	0.2	0.9	0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.1	5.9	-1.3	1.5	0.9	2.0	0.9	0.5	0.6	0.1	2.4	0.8	0.9	-0.1	-1.1	0.0	-0.1	-0.1	0.3	0.5
Rheumatoid Arthritis	0.4	0.6	2.4	-0.6	-0.2	-0.6	0.6	-0.7	-1.5	-0.9	0.2	0.0	1.3	-0.9	-0.8	-1.1	-0.3	-0.6	0.1	-0.4	-0.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	2.3	-1.5	-0.0	-0.3	-0.4	-0.7	-0.4	-0.6	0.4	-0.7	0.8	-1.5	-0.6	-0.9	-0.1	-0.9	-0.2	-0.8	-0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.7	1.2	0.5	0.4	-1.3	0.5	-1.0	0.1	0.5	-0.4	0.6	0.7	0.1	0.8	0.7	0.4	0.7	0.7	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	3.4	-0.4	-0.6	-0.6	-0.1	-0.8	-1.8	-0.4	1.0	-0.0	1.3	-0.2	-0.7	1.2	-0.5	-0.1	-0.3	0.1	-0.5
Multivitamins +/- minerals	0.4	0.5	5.6	0.8	0.2	0.2	-1.3	-0.1	-2.4	0.2	0.9	0.4	0.6	-0.3	0.2	0.0	-0.1	0.2	0.4	-0.2	0.1
Stomach or abdominal pain in last month	0.4	0.5	1.4	1.2	0.9	0.8	0.1	1.1	-0.0	1.1	1.1	0.3	0.3	-0.0	0.5	-0.9	0.6	0.2	0.5	0.3	0.6
Sitting height	0.4	2.7	11.4	0.1	2.1	0.8	-0.7	1.0	-3.4	0.8	2.1	0.4	2.7	-0.7	1.2	-2.1	2.3	-0.9	2.2	0.2	0.9
Hair/balding pattern: Pattern 2	0.4	0.5	2.5	0.4	0.0	-0.4	-1.5	-0.1	0.2	-0.6	-0.9	-1.3	-0.2	0.0	-0.3	-1.6	-0.2	-1.0	-0.1	-0.7	-0.5
Qualifications: None of the above	0.4	0.9	4.1	2.0	-0.8	-0.4	-0.6	-0.2	-2.0	-0.0	1.1	-0.5	1.5	-0.3	0.2	1.7	0.7	-0.2	0.5	-0.3	0.0
Diabetes (self-reported)	0.4	0.5	1.6	-0.1	-1.2	-0.7	0.2	-0.7	1.3	-1.1	-0.9	-0.7	-0.4	0.2	-0.7	-0.3	-0.4	-0.4	-0.5	-0.9	-0.8
Medication: Simvastatin	0.4	0.6	3.5	1.9	0.5	0.7	0.2	0.4	1.1	0.9	0.5	0.7	0.3	0.5	0.5	-0.4	1.1	1.0	0.6	0.5	0.6
Hair/balding pattern: Pattern 4	0.4	1.1	3.3	-1.1	0.5	1.2	1.4	1.2	0.5	1.0	-0.1	0.4	-0.9	-0.3	0.5	1.8	0.5	1.7	0.6	1.5	1.2
Number of full brothers	0.4	0.6	2.1	0.6	-0.0	-0.1	-0.5	-0.0	-1.2	-0.0	1.4	0.0	1.5	-0.0	0.3	-0.7	1.0	-0.2	1.2	0.7	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	4.2	-1.1	-0.3	-0.4	-0.9	-0.7	0.2	0.3	-0.4	-1.3	0.6	-2.0	-0.1	-0.7	0.1	-0.3	0.3	0.0	-0.2
Friendships satisfaction	0.4	0.5	4.5	-1.5	0.1	0.2	0.4	0.3	2.1	0.1	-0.3	-0.7	-0.7	-0.2	-0.2	0.3	-0.4	0.1	-0.1	0.5	0.2
Medication for cholesterol	0.4	0.6	3.0	-1.7	0.8	0.4	0.3	0.9	0.4	-0.0	-0.5	0.9	-1.3	1.2	0.2	0.3	-0.5	0.4	-0.1	0.9	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.6	0.1	-0.5	-0.8	0.4	-1.1	-1.0	-0.1	1.3	-0.7	0.9	-1.1	-0.2	0.2	0.2	-0.2	0.3	-0.6	-0.6
Medication: Gliclazide	0.4	0.5	2.4	-0.9	-0.8	0.2	0.3	-0.1	1.1	-0.1	-0.0	0.0	-1.5	-0.9	0.1	0.4	-0.2	1.6	0.0	0.2	0.2
Miserableness	0.4	0.7	2.8	-0.3	-0.3	-0.7	-1.7	-0.8	-1.2	-0.6	0.5	0.1	1.6	0.2	-1.0	-0.3	-0.5	-1.4	-0.3	-0.1	-0.5
Ever taken oral contraceptive pill	0.4	0.4	2.4	-0.1	-0.5	-0.7	0.2	-0.2	0.4	-0.4	-0.3	0.0	0.3	1.5	-0.4	0.1	-0.7	-1.3	-0.6	-0.5	-0.8
Medication: Lisinopril	0.4	0.5	1.5	0.6	-0.7	-0.7	-1.0	-0.8	-0.1	-0.7	-0.3	-1.2	0.8	-0.7	-0.6	-0.7	0.4	-0.7	-0.1	-1.1	-0.7
Medication: Atorvastatin	0.4	0.5	1.6	-0.6	-0.6	-0.7	-0.6	-0.6	-1.1	-0.6	0.4	0.3	0.9	-0.5	-0.4	-0.8	-0.3	-1.3	0.0	-0.8	-0.5
Cholesterol lowering medication	0.4	0.6	2.3	0.6	-1.5	-0.7	-0.6	-1.1	0.6	-0.5	-0.7	-1.0	-0.4	-1.5	-0.4	-0.2	-0.5	-0.0	-0.5	-0.8	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.5	-1.6	-0.5	-0.3	-0.2	0.1	1.0	-1.0	-1.2	-0.7	-0.0	-0.1	-0.8	1.2	-0.3	0.3	-0.7	0.1	-0.4
Heart disease (siblings)	0.4	0.5	2.0	-1.1	0.5	0.2	0.8	0.4	0.1	0.2	1.1	0.7	0.4	-0.5	1.0	-0.5	1.2	0.4	1.4	0.1	0.5
Crohns Disease (2017)	0.3	0.6	6.0	2.5	-0.6	0.0	-0.0	-0.2	-0.6	0.6	0.9	0.5	-0.1	-0.3	0.6	-1.0	0.8	0.6	0.5	-0.1	0.4
LDL Cholesterol	0.3	0.5	2.2	0.9	-0.5	-0.5	-1.5	-0.3	0.1	-0.1	-1.0	0.4	-0.6	-0.3	-0.6	-0.9	-0.5	-0.8	-0.6	-1.0	-0.7
Blood Eosinophil Count	0.3	2.4	14.7	-3.1	1.0	0.6	0.2	1.2	3.8	-0.1	-1.2	-1.3	-1.2	-0.1	0.3	-2.9	0.7	-1.3	0.6	0.8	0.4
Heel T-Score	0.3	2.0	8.1	-1.9	2.8	1.7	0.6	2.2	0.1	1.5	-0.6	1.2	-1.3	0.7	1.8	-1.8	1.2	-0.3	1.1	-0.4	1.1
BMI	0.3	1.7	5.1	2.2	-0.3	0.6	1.7	1.4	0.8	0.1	0.6	0.5	1.9	2.2	0.6	2.1	1.4	0.4	1.3	1.5	0.4
Allergy or Eczema	0.3	0.7	2.2	-0.5	0.5	-0.4	-0.1	0.2	0.4	-0.8	-1.5	-1.1	-0.5	-0.6	-1.2	-1.0	-1.0	-1.4	-1.2	-0.6	-0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.5	0.7	-1.1	0.1	1.2	-0.2	0.7	-0.5	0.2	0.1	-1.2	0.6	0.1	1.4	-0.2	1.6	0.0	0.9	0.3
Lung FEV1/FVC ratio	0.3	1.5	5.9	-1.2	-0.4	-1.0	-1.7	-0.9	-1.2	-0.6	2.3	-1.2	2.4	-0.3	-1.0	-0.1	0.7	-1.3	0.2	-1.3	-0.8
Number of treatments/medications taken	0.3	0.5	3.3	0.8	-0.2	-0.4	-1.0	-0.4	-0.6	-0.3	-0.0	-0.4	0.3	-1.1	0.2	-1.8	0.6	-0.1	0.5	-0.9	-0.3
Average weekly fortified wine intake	0.3	0.3	1.7	-0.5	0.2	0.3	0.6	0.1	1.3	0.0	-1.3	-0.7	-0.6	0.0	0.2	0.8	0.0	0.6	-0.0	0.3	0.0
Fed-up feelings	0.3	0.5	1.9	-0.5	-0.7	-0.7	-0.7	-0.8	-1.0	-0.4	0.4	-0.6	1.1	-0.7	-1.4	0.6	-0.8	-0.4	-0.7	0.2	-0.7
Age when periods started (menarche)	0.3	0.8	7.0	0.6	0.6	0.0	0.6	0.3	-2.6	-0.5	0.8	0.9	1.8	0.8	-0.1	0.1	0.4	-0.9	0.1	-0.4	0.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.6	-1.2	0.2	-0.3	0.6	-0.0	0.8	-0.8	-1.1	-0.9	-0.4	-0.5	-1.3	-0.7	-1.1	-1.2	-1.0	-0.1	-0.7
Chronic bronchitis/emphysema (father)	0.3	0.3	1.5	0.9	-0.4	0.4	0.0	0.4	0.8	0.3	-0.3	-0.1	-1.2	-0.1	0.4	-0.7	0.5	0.6	0.6	0.6	0.6
Body mass index (BMI)	0.3	1.4	4.7	2.1	-0.1	0.5	1.0	1.1	1.4	0.2	0.4	0.5	1.6	2.2	0.8	1.6	1.6	0.4	1.1	0.7	0.3
Waist circumference	0.3	0.9	4.5	1.3	-0.3	0.2	0.1	0.3	-1.0	0.3	1.5	-0.1	2.1	0.6	0.7	1.0	1.4	0.3	1.5	0.7	0.3
Had menopause	0.3	0.4	2.2	0.4	-0.0	0.5	-0.3	0.3	1.4	0.5	-0.7	0.6	-1.5	0.1	0.3	-0.1	-0.2	0.9	-0.1	0.4	0.6
Hip circumference	0.3	1.5	7.8	0.9	0.8	0.5	0.4	1.1	-0.7	0.8	1.7	1.0	2.8	1.7	1.0	-0.1	1.8	-0.4	1.7	0.5	0.4
Hair/balding pattern: Pattern 3	0.3	0.5	1.4	0.6	0.4	0.5	0.3	0.6	0.8	0.9	0.8	1.2	-0.6	0.5	1.1	0.4	0.5	0.8	0.6	0.5	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	2.0	-1.1	-0.5	-0.3	0.8	-0.3	0.2	-0.9	0.0	0.0	0.5	0.5	-0.4	1.4	-0.1	-0.1	-0.1	0.6	-0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	0.0	-0.8	-0.4	0.5	-0.7	1.2	-0.4	-0.5	-1.1	0.0	-0.2	-0.8	0.4	-0.8	-0.2	-1.0	0.0	-0.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.5	1.0	0.0	-0.3	-1.2	0.2	-1.1	-0.5	0.4	-0.2	1.1	0.4	-0.0	0.3	0.2	-0.8	-0.2	-0.6	-0.3
Leg fat percentage (right)	0.3	1.3	4.3	1.1	-2.1	-1.3	-0.6	-0.9	1.0	-1.6	-1.2	-0.1	0.3	1.0	-1.0	1.2	-1.1	-0.7	-1.2	-0.8	-1.4
Overall health rating	0.3	0.6	2.6	0.5	-0.7	-0.8	-1.0	-0.6	-1.6	-0.7	0.9	0.2	1.5	-1.4	-0.3	0.1	0.2	-0.3	0.2	-0.1	-0.6
Chest pain or discomfort	0.3	0.4	4.4	-0.6	-0.1	-0.5	0.2	-0.4	-0.3	-0.1	0.7	0.4	2.1	-0.3	0.2	-0.4	0.5	-0.4	0.4	-0.5	-0.3
Leg pain on walking	0.3	0.4	4.4	-1.0	-0.4	-0.1	-0.3	-0.1	-0.2	-0.0	0.0	-0.1	0.5	-0.0	0.0	2.1	0.4	0.7	0.4	0.1	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.7	-1.3	0.2	0.4	-0.1	0.6	1.3	-0.1	-0.3	0.6	-0.4	1.1	0.2	-0.1	-0.0	0.2	0.4	0.9	0.3
Loneliness, isolation	0.3	0.4	1.8	-0.7	-0.6	-0.5	-0.6	-0.6	-0.9	-0.1	0.7	-0.7	0.2	-1.4	-0.7	0.8	-0.7	-0.0	-0.4	0.1	-0.4
Long-standing illness, disability or infirmity	0.3	0.4	1.8	-0.5	-0.2	-0.6	-1.3	-0.7	-1.2	-1.2	-0.1	0.0	0.6	-0.5	-0.5	-0.5	-0.3	-0.7	0.3	-0.4	-0.5
Number of self-reported non-cancer illnesses	0.3	0.6	1.6	1.3	0.4	0.8	-0.1	0.5	0.6	0.5	1.0	1.0	0.1	0.9	0.5	0.6	0.9	1.1	0.8	0.8	0.8
Guilty feelings	0.3	0.4	1.9	-1.3	-0.3	-0.3	-0.9	-0.2	-1.3	-0.5	-0.5	-0.5	-0.3	-1.4	0.0	0.4	-0.4	-0.2	-0.0	0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	-0.5	1.0	0.5	0.2	0.3	-0.5	0.2	1.0	0.2	0.3	0.1	0.4	0.2	0.3	0.5	0.9	0.6	0.5
Pain experienced in last month	0.3	0.5	1.5	-0.7	0.5	0.6	-0.2	0.5	1.2	0.2	-0.0	-0.4	-1.2	0.3	0.4	0.8	0.0	0.8	0.5	1.1	0.7
Depressed Affect (Nagel 2018)	0.2	0.5	1.9	-0.4	-0.7	-0.6	-0.1	-0.7	-0.9	-0.4	0.1	-0.5	0.9	-1.4	-1.3	0.4	-0.9	-0.4	-0.8	0.5	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	1.8	0.8	-0.7	-0.1	1.3	-0.0	0.5	0.4	1.1	0.3	0.5	-0.1	0.1	0.1	0.1	0.7	0.2	0.2	0.0
Waist Hip Ratio (WHR)	0.2	1.0	3.9	-1.2	-1.7	-0.7	0.1	-1.7	-0.8	-0.6	0.6	-1.7	-0.7	-2.0	-0.4	0.8	-0.8	0.8	0.0	0.1	-0.3
Respiratory disease	0.2	0.5	1.4	0.8	0.8	0.7	-0.0	0.9	-0.1	0.8	0.9	-0.8	0.9	0.2	0.2	1.2	0.5	0.4	0.5	1.1	0.5
Tanning	0.2	1.9	4.9	-0.0	-1.5	-1.7	-0.3	-2.1	-1.6	-1.7	-0.4	-0.2	1.0	-0.4	-1.8	-0.3	-2.2	-1.7	-1.4	-1.0	-1.7
Ever had hysterectomy (womb removed)	0.2	0.2	1.4	1.2	0.8	0.3	-0.1	0.4	-0.8	-0.0	0.3	0.8	-0.1	0.5	0.3	-0.1	0.3	-0.2	-0.0	-0.5	-0.1
Medication: Metformin	0.2	0.3	1.3	0.5	-0.4	0.2	1.1	0.1	0.4	-0.7	-0.2	0.6	-0.1	1.1	0.1	0.9	0.2	0.7	0.1	0.5	0.1
Diabetes (mother)	0.2	0.2	1.6	-0.5	-0.5	-0.3	-1.2	-0.6	-1.1	-0.3	-0.0	-0.2	0.5	0.4	-0.0	0.2	-0.2	0.0	0.3	0.1	-0.1
Trunk fat percentage	0.2	0.6	2.0	0.2	-1.4	-0.7	0.4	-0.5	1.1	-1.2	-0.3	-0.3	0.9	0.7	-1.0	1.1	-0.5	-0.3	-0.8	-0.2	-1.0
Medication: Levothyroxine sodium	0.2	0.4	2.4	0.2	0.1	-0.3	-0.7	-0.1	0.8	-0.5	-0.8	0.4	0.9	1.6	-0.2	-0.2	0.6	-0.7	0.5	-0.0	-0.4
Allergy	0.2	0.6	1.4	0.9	0.5	0.5	-0.8	0.4	-1.2	0.4	0.5	0.9	0.1	0.6	1.2	0.5	1.0	0.9	1.1	0.2	0.7
Arm fat percentage (right)	0.2	0.7	4.1	0.8	-1.0	-0.3	0.4	0.1	2.0	-0.7	-0.3	-0.6	1.1	1.2	-0.5	1.2	0.2	-0.1	-0.2	-0.1	-0.6
Asthma	0.2	0.5	1.9	1.2	-0.5	0.2	1.4	-0.2	0.5	0.9	1.0	-0.1	0.6	0.3	-0.0	1.1	0.0	0.5	-0.2	0.6	0.2
Arm fat mass (right)	0.2	0.8	4.4	1.0	0.0	0.3	0.9	1.0	0.7	0.2	0.9	0.2	2.1	1.2	0.5	1.2	1.4	0.1	0.9	0.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.5	-0.2	0.6	0.2	1.0	0.1	-0.3	0.2	0.9	0.7	1.2	1.2	-0.2	0.2	0.1	-0.4	0.1	0.4	0.0
Body fat percentage	0.2	0.8	2.8	0.5	-1.7	-0.9	0.1	-0.7	1.2	-1.3	-0.5	-0.3	0.8	0.7	-1.0	1.2	-0.7	-0.4	-0.9	-0.4	-1.1
Medication: Omeprazole	0.2	0.2	1.1	0.5	-0.2	-0.2	-1.1	-0.0	0.2	-0.0	-0.5	0.2	0.9	0.2	-0.2	0.1	0.2	-0.5	0.3	-0.4	-0.4
Whole body fat mass	0.2	0.6	3.5	1.2	-0.4	0.1	0.7	0.5	-0.2	-0.1	1.2	0.6	1.9	1.1	0.3	1.1	0.9	0.0	0.6	0.2	-0.1
Leg fat mass (right)	0.2	0.6	5.0	1.4	-0.6	-0.5	0.3	0.3	-0.3	-0.5	0.6	0.4	2.2	1.0	-0.1	0.8	0.7	-0.6	0.4	-0.2	-0.6
Arm fat percentage (left)	0.2	0.7	3.4	1.4	-1.2	-0.3	0.3	0.1	1.8	-0.7	-0.3	-0.4	0.9	1.2	-0.5	1.1	0.1	0.0	-0.3	0.0	-0.6
Asthma (self-reported)	0.2	0.5	2.0	0.8	-0.6	0.0	1.4	-0.3	0.5	0.7	0.9	-0.1	0.9	0.3	-0.3	1.3	-0.2	0.3	-0.5	0.6	0.0
Arm fat mass (left)	0.2	0.8	3.8	1.3	-0.2	0.3	0.9	0.9	0.5	0.2	1.0	0.5	1.9	1.4	0.5	0.9	1.3	0.1	1.0	0.5	0.2
Mother’s age at death	0.2	0.2	1.1	-0.2	-0.2	0.2	-0.8	0.2	-0.1	0.1	-0.7	0.1	-0.2	-0.5	-0.2	1.1	-0.8	0.6	-0.3	0.5	0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	3.3	1.2	-0.4	0.2	-0.3	0.1	-1.8	-0.0	0.3	0.4	0.1	-0.3	0.1	-0.0	0.4	0.2	-0.2	-0.2	0.1
High cholesterol (Self-reported)	0.2	0.3	1.3	1.1	0.5	0.6	-0.4	0.3	0.4	0.6	0.5	0.7	0.1	0.6	0.5	-0.7	0.8	0.3	0.5	0.4	0.6
Commuting to job workplace: Cycle	0.2	0.2	1.3	0.1	-0.6	-0.3	1.1	-0.6	-0.4	-0.5	-0.3	0.2	-0.2	0.0	-0.6	-0.5	-0.9	-0.2	-0.2	0.4	-0.2
Leg fat mass (left)	0.2	0.7	4.1	1.5	-0.2	0.1	0.3	0.7	-0.2	-0.1	1.1	0.7	2.0	1.0	0.5	0.7	1.2	-0.2	0.9	0.2	-0.0
Hair Pigment	0.1	1.7	6.8	-1.9	-1.3	-0.9	-0.2	-0.5	2.1	-0.9	-2.6	-1.9	-0.8	-1.5	-1.0	-1.0	-1.1	-0.7	-0.7	-0.6	-0.7
Trunk fat mass	0.1	0.5	3.4	0.8	-0.3	-0.0	0.6	0.5	-0.4	-0.3	1.1	0.6	1.8	1.1	0.1	0.6	0.8	-0.2	0.4	0.1	-0.2
Diabetes diagnosed by doctor	0.1	0.2	1.3	-0.0	-0.9	-0.3	-0.1	-0.5	1.1	-0.5	0.1	-0.3	-0.2	0.4	-0.2	-0.2	0.1	0.2	0.2	-0.3	-0.3
Leg fat percentage (left)	0.1	0.5	1.6	1.3	-1.2	-0.4	-0.5	-0.1	1.0	-0.7	-0.4	0.6	0.1	1.0	-0.1	1.1	-0.1	-0.1	-0.2	-0.0	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	1.0	0.3	-0.3	-0.3	-0.4	-0.2	1.0	-0.2	-0.8	-0.2	0.2	0.1	-0.2	0.5	-0.2	-0.4	0.1	-0.5	-0.5

Hub : Genes

CALHM2

Models

Trait associations