TWAS hub - INA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.207	0.0390	0.0e+00	0.306	0.265	0.285	0.290	0.299	8.8e-38	3.7e-32	7.5e-35	1.2e-35	6.9e-37
2	ROSMAP	Brain Pre-frontal Cortex	0.120	0.0364	3.8e-08	0.047	0.057	0.050	0.054	0.061	8.8e-07	7.4e-08	4.7e-07	1.7e-07	2.3e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Systolic blood pressure, automated reading	13.1	38.1	41.5	-6.4	-5.9
Birth weight	9.5	20.6	29.0	5.4	3.5
Average weekly spirits intake	8.8	10.9	11.4	-3.4	-3.2
Heart attack	8.0	10.3	10.8	-3.1	-3.3
Angina (self-reported)	7.5	9.9	10.1	-3.2	-3.1
Heart attack/myocardial infarction (self-reported)	7.4	9.6	10.3	-3.0	-3.2
Age at First Birth	7.2	10.5	10.7	3.3	3.2
Crohns Disease (2012)	7.2	11.6	12.1	-3.3	-3.5
Current tobacco smoking	6.8	11.1	16.7	-2.3	-4.1
Vascular/heart problems diagnosed by doctor	6.7	18.3	21.5	3.9	4.6
Smoking Status	6.6	15.7	27.6	-2.0	-5.2
Past tobacco smoking	6.6	12.1	20.0	2.0	4.5
Smoking status: Current	6.4	10.2	16.6	-2.0	-4.1
Systolic Blood Pressure	6.3	31.3	36.5	-6.0	-5.1
Pain type(s) experienced in last month: Hip pain	6.1	7.6	7.7	-2.8	-2.8
Coronary Artery Disease (CAD)	6.0	7.2	9.6	-3.1	-2.2
Schizophrenia vs Biploar Disorder	5.8	7.6	10.0	-3.2	-2.3
Angina	5.5	7.2	7.3	-2.7	-2.7
Tense / ‘highly strung’	5.2	8.6	9.1	-2.9	-3.0
Ever smoked	5.0	8.8	14.7	-1.7	-3.8
Diastolic blood pressure, automated reading	4.9	15.1	19.0	-3.4	-4.4
High blood pressure	4.4	12.4	15.1	-3.1	-3.9
Maternal smoking around birth	4.2	6.1	10.1	-1.5	-3.2
Supplements: Glucosamine	4.1	5.3	6.5	-2.0	-2.5
Illnesses of father: None of the above (group 1)	3.9	4.8	5.1	2.1	2.2
Medication: Blood pressure	3.9	7.4	9.6	-2.3	-3.1
Schizophrenia (2018)	3.8	8.0	14.4	-3.8	-1.2
Hypertension (Self-reported)	3.8	10.7	13.2	-2.9	-3.6
High blood pressure (mother)	3.7	5.1	5.9	-2.4	-2.1
Migraine (self-reported)	3.7	4.6	5.4	2.3	2.0
Supplements: Calcium	3.7	4.1	5.4	-1.7	-2.3
Glaucoma (self-reported)	3.6	4.2	5.5	-2.3	-1.7
Smoking status: Previous	3.6	5.3	8.2	-1.6	-2.9
Chronotype (morning person)	3.5	8.1	10.2	3.2	2.4
Neck or shoulder pain in last month	3.5	5.0	5.1	-2.2	-2.2
Fractured/broken bones in last 5 years	3.5	4.5	5.9	-2.4	-1.8
Serious illness, injury or assault to yourself	3.3	4.0	4.3	-2.1	-1.9
Time employed in main current job	3.3	3.8	4.1	2.0	1.8
Worry too long after embarrassment	3.3	5.6	7.6	-2.8	-1.9
Age at first live birth	3.3	5.8	6.6	2.3	2.6
Had major operations	3.3	3.9	4.0	-2.0	-2.0
Cholesterol lowering medication	3.3	4.9	5.4	-2.3	-2.1
Crohns Disease (2017)	3.2	7.0	7.5	-2.6	-2.7
Tinnitus: Yes, but not now, but have in the past	3.2	3.4	4.5	-1.5	-2.1
Alcohol intake versus 10 years previously	3.1	4.6	6.9	-1.5	-2.6
Falls in the last year	3.1	4.3	6.4	-1.4	-2.5
Major Depression (MDD)	3.0	3.6	4.0	-2.0	-1.8
Pack years of smoking	3.0	4.3	5.5	-1.8	-2.3
Schizophrenia (2014)	2.9	6.3	11.1	-3.3	-1.2
Back pain experienced in last month	2.9	4.3	5.2	-1.8	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	4.4	-1.5	-2.1
Eye problems/disorders: Glaucoma	2.8	3.3	4.9	-2.2	-1.3
Mineral and other dietary supplements	2.7	3.6	5.0	1.5	2.2
Worry (Nagel 2018)	2.6	5.4	9.5	-3.1	-1.1
Lung FVC	2.6	13.4	14.4	-3.8	-3.5
Pack years adult smoking proportion	2.6	4.0	5.1	-1.7	-2.3
Illnesses of siblings	2.6	3.7	5.0	1.5	2.2
Average weekly champagne plus white wine intake	2.6	3.5	4.3	1.7	2.1
Illnesses of mother	2.5	3.1	3.1	1.8	1.7
Illnesses of siblings: Diabetes	2.5	3.1	3.7	1.9	1.6
Osteoporosis (self-reported)	2.5	3.1	3.4	-1.7	-1.8
Illnesses of father: Heart disease	2.4	3.4	3.6	-1.9	-1.8
Verbal and Numeric Reasoning (VNR)	2.3	5.6	6.8	2.6	2.1
Heel T-Score	2.3	18.0	24.8	3.3	5.0
Medication: Atenolol	2.3	2.9	3.0	-1.7	-1.7
Comparative body size at age 10	2.3	6.2	6.7	-2.4	-2.6
Severe depression (siblings)	2.2	2.5	2.9	-1.7	-1.5
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	2.9	1.7	1.7
Cardiovascular Disease	2.1	6.8	8.8	-2.2	-3.0
Family relationship satisfaction	2.1	2.6	3.0	-1.5	-1.7
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	3.5	-1.2	-1.9
Intelligence (Savage-Jansen 2018)	2.0	6.0	6.9	2.6	2.3
Medication: Co-codamol	2.0	2.4	2.4	-1.6	-1.5
Fluid intelligence score	2.0	4.2	4.2	2.0	2.0
Number of live births	2.0	2.9	3.8	-1.9	-1.4
Medication: Bendroflumethiazide	2.0	3.0	4.1	-1.4	-2.0
Body Mass Index (BMI) (2010)	1.9	2.7	3.6	-1.3	-1.9
Type 2 Diabetes (T2D) (2018)	1.9	3.6	3.9	-1.8	-2.0
Vitamin and mineral supplements	1.9	2.6	3.3	1.4	1.8
Birth weight of first child	1.9	3.5	6.4	2.5	0.8
Commuting to job workplace: Walk	1.9	2.1	2.1	-1.5	-1.4
Osteoarthritis (self-reported)	1.9	2.5	2.6	-1.5	-1.6
Blood White Count	1.8	13.1	19.1	-2.6	-4.4
Neuroticism	1.8	4.4	6.8	-2.6	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.0	6.8	1.1	2.6
Medication for cholesterol	1.8	2.7	3.9	1.2	2.0
Bipolar Disorder or Schizophrenia	1.7	4.1	7.9	-2.8	-0.6
Relative age voice broke	1.7	2.6	2.7	-1.6	-1.6
Nervous feelings	1.7	3.3	6.1	-2.5	-0.7
High blood pressure (siblings)	1.7	2.4	3.3	-1.3	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	1.9	2.1	-1.3	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	5.5	-2.3	-1.3
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.0	-1.2	-1.7
Neuroticism (Nagel 2018)	1.6	3.6	5.2	-2.3	-1.5
Lupus	1.6	2.4	3.5	1.9	1.1
Allergy or Eczema	1.6	4.2	5.1	1.8	2.3
Sensitivity / hurt feelings	1.6	2.8	4.2	-2.0	-1.2
Average weekly beer plus cider intake	1.6	2.3	3.4	1.8	1.1
Irritability	1.6	2.7	4.8	-0.8	-2.2
Hayfever, allergic rhinitis or eczema	1.5	3.2	4.0	1.5	2.0
Medication: Gliclazide	1.5	1.7	1.8	-1.3	-1.4
Impedance of leg (right)	1.4	6.9	10.9	-3.3	-1.7
Average weekly fortified wine intake	1.4	1.6	2.4	0.9	1.5
Impedance of leg (left)	1.4	6.9	10.2	-3.2	-1.9
Qualifications: None of the above	1.4	3.0	4.4	-1.3	-2.1
Mean time to correctly identify matches	1.4	2.7	3.0	-1.7	-1.5
Ulcerative Colitis (UC)	1.3	2.4	3.4	1.9	1.1
Primary Biliary Cirrhosis	1.3	1.9	2.4	-1.5	-1.2
Hand grip strength (right)	1.3	3.7	4.6	-1.6	-2.1
Overall health rating	1.3	2.7	3.8	-1.3	-2.0
Risk taking	1.3	1.9	3.5	-0.6	-1.9
Chronic bronchitis/emphysema (father)	1.2	1.5	1.9	-1.4	-1.0
Mood swings	1.2	2.2	2.7	1.7	1.3
Illnesses of father: High blood pressure	1.2	1.4	1.6	-1.1	-1.3
Ever had hysterectomy (womb removed)	1.1	1.3	2.1	0.7	1.5
Gout (self-reported)	1.1	1.5	1.6	1.3	1.2
Leg fat percentage (right)	1.1	3.9	4.4	-1.8	-2.1
Heart disease (mother)	1.1	1.3	1.9	-1.4	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.3	-1.1	-1.1
Basal cell carcinoma (self-reported)	1.1	1.4	1.6	1.1	1.3
Depression (Nagel 2018)	1.0	1.5	1.8	-1.1	-1.3
Reaction Time	1.0	1.9	2.2	-1.5	-1.3
Number of treatments/medications taken	1.0	1.7	2.1	-1.2	-1.4
Financial difficulties in last 2 years	1.0	1.4	2.3	-0.7	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	1.8	-1.3	-1.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	2.4	1.6	0.8
Pulse wave peak to peak time	1.0	1.2	2.0	1.4	0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.9	-0.7	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.8	1.7	0.7
Heart disease (siblings)	1.0	1.2	1.4	-0.9	-1.2
Alcohol usually taken with meals	0.9	1.4	2.8	0.1	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	1.7	-1.0	-1.3
Medication: Ramipril	0.9	1.1	1.6	-1.3	-0.8
Pulse wave reflection index	0.9	1.1	1.7	1.3	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	1.3	1.1	0.9
Alcohol intake frequency.	0.9	2.1	2.1	-1.4	-1.4
Supplements: Vitamin C	0.9	1.0	1.7	-0.6	-1.3
Leg fat-free mass (right)	0.9	4.8	8.4	2.9	1.1
Breast cancer (self-reported)	0.9	1.1	1.8	1.4	0.6
Leg predicted mass (right)	0.9	4.8	8.4	2.9	1.1
Leg fat percentage (left)	0.9	3.3	4.2	-1.5	-2.0
Respiratory disease	0.8	1.7	2.5	1.6	1.0
Forced vital capacity (FVC)	0.8	3.0	3.5	-1.6	-1.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	2.9	-1.5	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	1.8	-1.3	-0.5
Emphysema/chronic bronchitis	0.8	0.9	1.0	-0.9	-1.0
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.8	1.3	0.4
Qualifications: nursing, teaching	0.8	1.2	2.3	-1.5	-0.3
Eye problems/disorders: Cataract	0.8	1.0	1.3	0.8	1.2
Financial situation satisfaction	0.8	1.0	1.9	1.4	-0.1
HbA1C	0.7	0.8	1.2	-1.1	-0.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	0.3	1.2
Blood Red Count	0.7	7.1	7.6	2.8	2.5
Waist Hip Ratio (WHR)	0.7	3.2	4.4	-2.1	-1.4
Relative age of first facial hair	0.7	1.5	2.7	-0.6	-1.6
Supplements: Zinc	0.7	0.8	1.4	-0.4	-1.2
Leg fat-free mass (left)	0.7	3.9	6.9	2.6	0.9
Leg predicted mass (left)	0.7	3.6	6.5	2.5	0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.1	1.0	1.5
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	-1.2	-0.4
Breastfed as a baby	0.7	0.9	1.7	0.3	1.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.8	1.4	0.2
Medication: Paracetamol	0.7	1.2	1.9	-1.4	-0.7
Exposure to tobacco smoke outside home	0.7	0.9	1.6	-0.5	-1.3
Medication: Ibuprofen	0.7	0.9	1.6	-1.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.0	1.0	0.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.2	0.6	1.1
Medication: Paracetamol	0.7	1.1	1.8	-1.3	-0.7
Ulcerative Colitis	0.6	0.8	1.1	1.1	0.7
Blood Eosinophil Count	0.6	4.7	5.3	2.0	2.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	-1.1	-0.5
Medication: Simvastatin	0.6	0.9	1.5	-0.5	-1.2
Trunk fat-free mass	0.6	3.2	5.5	2.3	0.9
Worrier / anxious feelings	0.6	1.1	2.0	-0.3	1.4
Trunk predicted mass	0.6	3.2	5.5	2.3	0.9
Peak expiratory flow (PEF)	0.6	1.4	2.0	-0.9	-1.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.0	1.0	0.7
Body fat percentage	0.6	2.5	3.3	-1.3	-1.8
Suffer from ‘nerves’	0.6	1.0	1.8	-1.3	-0.4
Chest pain or discomfort	0.6	0.9	1.6	-0.3	-1.3
Whole body fat-free mass	0.6	3.6	6.2	2.5	1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	0.9	0.7	0.9
Diabetes diagnosed by doctor	0.6	1.1	1.3	-0.9	-1.1
Whole body water mass	0.6	3.3	5.8	2.4	0.9
Impedance of whole body	0.6	2.9	4.7	-2.2	-1.1
Breast Cancer	0.5	1.2	1.6	0.8	1.3
Ever used hormone-replacement therapy (HRT)	0.5	0.7	0.7	0.8	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.1	-0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.1	-0.0	1.5
Number of incorrect matches in round	0.5	0.8	1.2	-0.6	1.1
Diabetes (self-reported)	0.5	0.8	0.9	-0.9	-0.8
Neuroticism score	0.5	1.1	1.6	-1.3	-0.8
Happiness	0.5	0.6	1.1	-1.0	-0.4
Lung cancer (father)	0.5	0.6	0.7	0.6	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	1.8	-1.1	-1.3
Loud music exposure frequency	0.5	0.5	0.9	-0.4	-0.9
Forced vital capacity (FVC), Best measure	0.5	1.7	1.8	-1.2	-1.4
Comparative height size at age 10	0.5	2.6	3.2	1.4	1.8
Knee pain experienced in last month	0.5	0.8	1.5	-0.4	-1.2
Hearing aid user	0.5	0.6	0.9	0.5	1.0
Basal metabolic rate	0.5	3.0	5.4	2.3	0.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.8	0.9	0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.2	0.3	1.1
Trunk fat percentage	0.4	1.6	2.4	-1.0	-1.5
Townsend deprivation index at recruitment	0.4	0.5	1.0	-0.1	-1.0
Stomach or abdominal pain in last month	0.4	0.5	0.6	0.8	0.6
Sitting height	0.4	2.7	3.6	1.9	1.3
Had menopause	0.4	0.5	0.9	-0.9	-0.5
Hair/balding pattern: Pattern 3	0.4	0.6	0.8	-0.6	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.6	1.2	-0.3	-1.1
Asthma	0.4	0.9	1.3	-0.6	-1.2
Medication: Cholesterol lowering	0.4	0.6	1.2	-0.2	-1.1
Headache pain in last month	0.4	0.8	0.9	1.0	0.8
Health satisfaction	0.4	0.5	0.6	-0.6	-0.8
Shortness of breath walking on level ground	0.4	0.4	0.5	0.7	0.6
Age at last live birth	0.4	0.5	0.7	0.8	0.6
Medication: Lisinopril	0.4	0.5	0.5	-0.7	-0.6
Pain experienced in last month	0.4	0.6	0.8	0.6	0.9
HDL Cholesterol	0.3	0.5	0.9	-0.9	0.3
Triglycerides	0.3	0.5	0.8	0.9	0.5
Height	0.3	5.2	7.6	2.8	1.7
Lung FEV1/FVC ratio	0.3	1.3	2.3	-0.6	-1.5
Hand grip strength (left)	0.3	0.9	1.6	-0.5	-1.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	0.8	0.5
Qualifications: CSEs or equivalent	0.3	0.5	0.8	0.9	0.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.4	0.8
Mouth/teeth dental problems	0.3	0.5	0.7	-0.5	0.8
Standing height	0.3	2.6	3.8	2.0	1.1
Length of working week for main job	0.3	0.4	0.4	-0.6	-0.6
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.4	0.5	0.6
Qualifications: College or University degree	0.3	1.0	1.5	-1.2	0.8
Medication: Seretide 50 evohaler	0.3	0.3	0.7	0.8	-0.1
Whole body fat mass	0.3	1.3	2.4	-0.5	-1.5
Leg fat mass (right)	0.3	1.2	2.1	-0.5	-1.4
Arm predicted mass (right)	0.3	1.3	2.5	1.6	0.2
Leg pain on walking	0.3	0.4	0.6	-0.6	-0.7
Arm fat percentage (left)	0.3	1.3	2.2	-0.6	-1.5
Friendships satisfaction	0.3	0.4	0.6	0.5	0.7
Asthma (self-reported)	0.3	0.6	1.0	-0.4	-1.0
Commuting to job workplace: Public transport	0.3	0.4	0.7	-0.2	0.9
Arm fat-free mass (left)	0.3	1.7	3.2	1.8	0.5
Unable to work because of sickness or disability	0.3	0.4	0.7	0.8	-0.4
Alcohol drinker status: Previous	0.3	0.3	0.4	-0.6	-0.5
Leg fat mass (left)	0.3	1.1	2.1	-0.4	-1.5
Arm predicted mass (left)	0.3	1.7	3.2	1.8	0.5
Bipolar Disorder (2018)	0.2	0.2	0.4	0.2	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.7	0.3
Prostate Cancer	0.2	0.3	0.3	-0.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.5	-0.2	-0.7
Diabetes (father)	0.2	0.2	0.3	-0.4	-0.5
Taking other prescription medications	0.2	0.3	0.4	0.7	0.3
Age when periods started (menarche)	0.2	0.6	1.2	1.1	0.1
Trunk fat mass	0.2	0.7	1.4	-0.2	-1.2
Waist circumference	0.2	0.9	1.7	-0.3	-1.3
Hearing difficulty/problems with background noise	0.2	0.3	0.5	0.7	0.1
Arm fat percentage (right)	0.2	0.7	1.3	-0.2	-1.1
Medication: Lansoprazole	0.2	0.2	0.3	0.4	0.6
Impedance of arm (left)	0.2	0.8	1.4	-1.2	-0.5
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	0.1	0.9
Arm fat-free mass (right)	0.2	1.1	2.2	1.5	0.1
Number of full brothers	0.2	0.3	0.4	0.3	-0.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.3	0.5	-0.6
Eye problems/disorders: None of the above	0.2	0.3	0.3	-0.5	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	0.9	0.3
Medication: Aspirin	0.2	0.3	0.5	-0.3	-0.7
Arm fat mass (left)	0.2	0.6	1.2	0.1	-1.1
Number of operations (self-reported)	0.2	0.4	0.7	0.2	0.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	0.4	-0.0
Alzheimer’s Disease (in father)	0.1	0.2	0.3	0.6	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	-0.2	-0.8
Ovarian Cancer	0.1	0.2	0.3	-0.1	-0.5
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.4	-0.0
Mean Putamen Volume	0.1	0.1	0.1	0.3	0.1
Rheumatoid Arthritis	0.1	0.1	0.2	0.1	-0.4
Blood Platelet Count	0.1	1.4	2.3	0.7	-1.5
BMI	0.1	0.3	0.4	0.5	-0.6
Hypothyroidism (self reported)	0.1	0.2	0.3	-0.3	-0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.3	-0.4
Medication for hormone replacement therapy	0.1	0.1	0.1	0.3	0.1
Medication: Metformin	0.1	0.2	0.2	-0.4	-0.5
Diabetes (mother)	0.1	0.1	0.1	-0.4	-0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.1	0.4
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.5	0.4
Body mass index (BMI)	0.1	0.4	0.8	0.2	-0.9
Had other major operations	0.1	0.1	0.1	0.4	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.2	-0.5
Allergy	0.1	0.3	0.5	-0.4	-0.7
Pain all over the body in last month	0.1	0.1	0.1	0.3	0.3
Weight	0.1	0.7	1.2	1.1	-0.3
Impedance of arm (right)	0.1	0.5	1.0	-1.0	-0.3
Hip circumference	0.1	0.5	0.7	0.8	-0.6
Father’s age at death	0.1	0.2	0.2	-0.4	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.1	-0.6
Pulse rate	0.1	0.1	0.2	-0.5	0.0
Noisy workplace	0.1	0.1	0.2	-0.2	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.3	-0.4
Depression (self-reported)	0.1	0.1	0.2	0.4	0.3
Prospective memory result	0.1	0.1	0.2	-0.5	-0.1
Arm fat mass (right)	0.1	0.3	0.6	0.3	-0.7
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.4	-0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.5	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.2	0.4	0.4
Medication: Amlodipine	0.1	0.2	0.4	0.6	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.1	-0.4
Pulse rate, automated reading	0.1	0.2	0.4	0.4	0.6
Medication: Aspirin	0.1	0.1	0.1	0.1	-0.3
Average weekly red wine intake	0.1	0.1	0.2	-0.4	-0.0
Loneliness, isolation	0.1	0.1	0.2	-0.1	-0.5
Ever had bowel cancer screening	0.1	0.1	0.2	0.5	-0.2
Miserableness	0.1	0.2	0.4	0.6	0.2
Wears glasses or contact lenses	0.1	0.1	0.1	-0.3	0.3
High cholesterol (Self-reported)	0.1	0.2	0.2	-0.3	-0.5
Medication: Atorvastatin	0.1	0.2	0.3	-0.2	-0.5
Alcohol drinker status: Never	0.1	0.2	0.3	0.2	0.5
Myopia	0.1	0.1	0.2	0.4	0.3
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	0.3	-0.1
Fasting Glucose	0.0	0.0	0.0	0.2	-0.0
LDL Cholesterol	0.0	0.0	0.1	-0.3	-0.0
Neuroticism (2016)	0.0	0.1	0.1	0.1	-0.3
Hair Pigment	0.0	0.3	0.5	-0.5	0.7
Tanning	0.0	0.4	0.7	-0.5	-0.8
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	0.2	-0.0
Fed-up feelings	0.0	0.1	0.1	0.4	-0.2
Multivitamins +/- minerals	0.0	0.0	0.0	0.1	-0.2
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	-0.1	0.2
Number of children fathered	0.0	0.0	0.0	0.1	-0.1
Medication: Blood pressure	0.0	0.1	0.1	0.1	-0.4
Medication: Allopurinol	0.0	0.1	0.1	-0.3	-0.2
Medication: Omeprazole	0.0	0.0	0.1	0.3	-0.0
Number of full sisters	0.0	0.0	0.0	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	0.4	-0.1
Long-standing illness, disability or infirmity	0.0	0.0	0.1	-0.0	-0.3
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	0.1	-0.4
Guilty feelings	0.0	0.0	0.0	-0.1	0.1
Ever taken oral contraceptive pill	0.0	0.0	0.0	-0.2	-0.1
Mother’s age at death	0.0	0.0	0.1	-0.2	0.3
Age started oral contraceptive pill	0.0	0.0	0.0	-0.2	0.2
Ever depressed for a whole week	0.0	0.0	0.0	-0.0	-0.1
Commuting to job workplace: Cycle	0.0	0.0	0.0	0.1	0.0
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.2	-0.0

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Trait associations