Best TWAS P=4.64e-13 · Best GWAS P=2.7e-11 conditioned to 0.0323
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | LRP4 | 0.04 | 0.05 | lasso | 4 | 0.04 | 6.6e-06 | 5.4 | 5.6 | 1.9e-08 | 0.66 | 0.78 | 0.20 | FALSE |
2 | GTEx | Adipose Subcutaneous | ARHGAP1 | 0.08 | 0.03 | lasso | 6 | 0.05 | 3.4e-05 | 5.4 | -6.3 | 2.9e-10 | -0.84 | 0.25 | 0.69 | FALSE |
3 | GTEx | Breast Mammary Tissue | ARHGAP1 | 0.05 | 0.00 | enet | 14 | 0.01 | 1.3e-01 | 6.2 | -5.4 | 6.3e-08 | -0.79 | 0.08 | 0.46 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | LRP4 | 0.68 | 0.00 | lasso | 10 | 0.00 | 5.0e-01 | -3.4 | -5.2 | 2.6e-07 | -0.46 | 0.03 | 0.12 | FALSE |
5 | GTEx | Esophagus Mucosa | ARFGAP2 | 0.05 | 0.06 | lasso | 4 | 0.05 | 4.4e-04 | 5.1 | 5.2 | 1.9e-07 | 0.72 | 0.30 | 0.11 | FALSE |
6 | GTEx | Esophagus Muscularis | CKAP5 | 0.05 | 0.03 | lasso | 4 | 0.04 | 3.3e-03 | 5.1 | 6.0 | 2.2e-09 | 0.69 | 0.38 | 0.13 | FALSE |
7 | GTEx | Esophagus Muscularis | ARHGAP1 | 0.07 | 0.08 | lasso | 3 | 0.07 | 6.1e-05 | 5.1 | -5.5 | 3.2e-08 | -0.79 | 0.39 | 0.56 | FALSE |
8 | GTEx | Esophagus Muscularis | ATG13 | 0.12 | 0.08 | enet | 16 | 0.04 | 1.2e-03 | 6.3 | -5.2 | 1.6e-07 | -0.63 | 0.04 | 0.95 | FALSE |
9 | GTEx | Liver | ZNF408 | 0.10 | 0.09 | lasso | 3 | 0.08 | 3.5e-03 | 6.4 | -6.9 | 4.8e-12 | -0.95 | 0.05 | 0.56 | FALSE |
10 | GTEx | Liver | ARHGAP1 | 0.12 | 0.05 | enet | 4 | 0.05 | 1.5e-02 | 5.9 | -7.2 | 4.6e-13 | -0.71 | 0.05 | 0.46 | TRUE |
11 | GTEx | Muscle Skeletal | ARHGAP1 | 0.03 | 0.05 | lasso | 2 | 0.04 | 1.2e-04 | 6.2 | -6.2 | 7.4e-10 | -0.93 | 0.04 | 0.93 | FALSE |
12 | GTEx | Nerve Tibial | ARHGAP1 | 0.10 | 0.03 | enet | 14 | 0.05 | 9.7e-05 | 6.4 | -5.9 | 2.8e-09 | -0.88 | 0.09 | 0.90 | FALSE |
13 | GTEx | Nerve Tibial | LRP4-AS1 | 0.23 | 0.16 | enet | 15 | 0.24 | 1.1e-16 | -3.4 | 5.2 | 2.1e-07 | 0.60 | 0.98 | 0.02 | FALSE |
14 | GTEx | Ovary | ARHGAP1 | 0.25 | 0.09 | lasso | 16 | 0.18 | 3.8e-05 | 6.1 | -7.0 | 1.8e-12 | -0.84 | 0.09 | 0.71 | FALSE |
15 | GTEx | Pancreas | LRP4 | 0.11 | 0.10 | enet | 16 | 0.14 | 1.8e-06 | 5.1 | -5.2 | 1.9e-07 | -0.76 | 0.57 | 0.39 | FALSE |
16 | GTEx | Pancreas | ARHGAP1 | 0.09 | 0.06 | lasso | 7 | 0.04 | 6.4e-03 | 6.2 | -6.3 | 2.7e-10 | -0.92 | 0.06 | 0.74 | FALSE |
17 | GTEx | Pancreas | LRP4-AS1 | 0.10 | 0.08 | lasso | 6 | 0.12 | 1.4e-05 | 5.1 | -5.4 | 7.8e-08 | -0.76 | 0.40 | 0.49 | FALSE |
18 | GTEx | Prostate | CELF1 | 0.17 | 0.16 | lasso | 2 | 0.12 | 6.2e-04 | 5.4 | 5.4 | 5.4e-08 | 0.60 | 0.03 | 0.84 | FALSE |
19 | GTEx | Prostate | ZNF408 | 0.19 | 0.10 | lasso | 2 | 0.10 | 1.6e-03 | 5.3 | -5.3 | 1.0e-07 | -0.65 | 0.14 | 0.11 | FALSE |
20 | GTEx | Skin Not Sun Exposed Suprapubic | ARHGAP1 | 0.06 | 0.01 | lasso | 9 | 0.00 | 2.8e-01 | 5.3 | -6.2 | 4.2e-10 | -0.84 | 0.10 | 0.46 | FALSE |
21 | GTEx | Skin Not Sun Exposed Suprapubic | ATG13 | 0.12 | 0.07 | lasso | 5 | 0.06 | 3.3e-04 | 5.8 | -6.0 | 1.5e-09 | -0.64 | 0.06 | 0.94 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | DDB2 | 0.08 | 0.10 | lasso | 4 | 0.10 | 5.8e-09 | 5.1 | 5.7 | 1.0e-08 | 0.70 | 0.28 | 0.72 | FALSE |
23 | GTEx | Skin Sun Exposed Lower leg | ARHGAP1 | 0.08 | 0.01 | lasso | 5 | 0.02 | 1.4e-02 | 6.2 | -5.8 | 6.5e-09 | -0.87 | 0.13 | 0.55 | FALSE |
24 | GTEx | Skin Sun Exposed Lower leg | ATG13 | 0.08 | 0.05 | lasso | 4 | 0.05 | 5.1e-05 | 6.4 | -5.6 | 1.6e-08 | -0.66 | 0.05 | 0.95 | FALSE |
25 | GTEx | Spleen | LRP4 | 0.15 | 0.14 | lasso | 5 | 0.12 | 6.5e-04 | 6.0 | -6.0 | 2.5e-09 | -0.46 | 0.12 | 0.32 | FALSE |
26 | GTEx | Thyroid | C11orf49 | 0.09 | 0.05 | lasso | 3 | 0.04 | 3.0e-04 | 6.0 | -5.9 | 2.8e-09 | -0.46 | 0.33 | 0.63 | FALSE |
27 | GTEx | Uterus | C11orf49 | 0.24 | 0.24 | lasso | 13 | 0.24 | 1.3e-05 | 5.8 | -5.8 | 5.2e-09 | -0.47 | 0.11 | 0.23 | FALSE |
28 | METSIM | Adipose | DDB2 | 0.03 | 0.03 | lasso | 2 | 0.02 | 1.9e-04 | 5.4 | -5.4 | 5.7e-08 | -0.55 | 0.19 | 0.77 | FALSE |
29 | ROSMAP | Brain Pre-frontal Cortex | C11orf49 | 0.02 | 0.02 | blup | 322 | 0.02 | 3.3e-04 | 5.2 | 5.3 | 1.4e-07 | 0.73 | 0.82 | 0.11 | FALSE |
30 | ROSMAP | Brain Pre-frontal Cortex | PACSIN3 | 0.11 | 0.00 | bslmm | 292 | 0.04 | 1.8e-06 | -3.6 | 6.5 | 5.9e-11 | 0.46 | 0.08 | 0.55 | FALSE |
31 | YFS | Blood | PHF21A | 0.01 | 0.01 | bslmm | 385 | 0.00 | 1.9e-02 | 4.2 | 5.5 | 4.6e-08 | 0.33 | 0.60 | 0.13 | FALSE |
32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ARHGAP1 | 0.02 | 0.01 | blup | 26 | 0.02 | 2.7e-04 | 6.2 | -6.8 | 1.3e-11 | -0.88 | 0.01 | 0.82 | FALSE |
33 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MDK | 0.03 | 0.02 | lasso | 3 | 0.02 | 2.3e-03 | 6.3 | -5.5 | 3.4e-08 | -0.61 | 0.01 | 0.97 | FALSE |
34 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CKAP5 | 0.09 | 0.01 | blup | 58 | 0.04 | 2.9e-03 | 5.2 | 6.6 | 4.2e-11 | 0.63 | 0.04 | 0.78 | FALSE |
35 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ARHGAP1 | 0.11 | 0.01 | blup | 26 | 0.03 | 2.7e-02 | 5.3 | -6.1 | 1.4e-09 | -0.85 | 0.01 | 0.54 | FALSE |
36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF408 | 0.02 | 0.00 | blup | 27 | 0.02 | 4.3e-03 | 5.0 | -5.8 | 8.2e-09 | -0.87 | 0.01 | 0.60 | FALSE |
37 | The Cancer Genome Atlas | Stomach Adenocarcinoma | HARBI1 | 0.05 | 0.02 | blup | 12 | 0.02 | 1.5e-02 | 5.9 | 5.8 | 5.7e-09 | 0.68 | 0.01 | 0.75 | FALSE |
38 | The Cancer Genome Atlas | Thyroid Carcinoma | PACSIN3 | 0.09 | 0.01 | enet | 5 | 0.03 | 3.1e-04 | 5.5 | 5.3 | 1.5e-07 | 0.54 | 0.02 | 0.82 | FALSE |