Hub : Genes

LRP4-AS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.228 0.0594 3.1e-13 0.155 NA 0.236 NA 0.228 4.2e-11 NA 1.1e-16 NA 3.6e-16
2 GTEx Pancreas 0.102 0.0440 1.7e-05 0.076 NA 0.069 NA 0.116 4.1e-04 NA 7.2e-04 NA 1.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.4 2.2 2.4 1.5 -1.4
Bipolar Disorder or Schizophrenia 3.8 9.2 10.2 2.9 -3.2
Depressed Affect (Nagel 2018) 5.6 11.8 15.8 -2.8 4.0
Depression (Nagel 2018) 3.1 4.7 5.8 -1.9 2.4
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.5 0.5 1.2
Neuroticism (Nagel 2018) 5.0 11.8 16.8 -2.6 4.1
Schizophrenia (2018) 3.6 7.4 8.8 2.5 -3.0
Schizophrenia vs Biploar Disorder 6.0 7.9 7.9 2.8 -2.8
Worry (Nagel 2018) 1.6 3.4 6.3 -0.7 2.5
Alzheimer’s Disease (in mother) 1.0 1.1 2.1 1.4 -0.5
Alzheimer’s Disease (in father) 0.3 0.4 0.4 0.7 -0.5
Alzheimer’s Disease (including proxy) 1.0 1.4 2.8 1.7 -0.3
Crohns Disease (2017) 0.4 0.9 1.3 -1.2 0.7
Irritable Bowel Disease (IBD) 0.1 0.3 0.3 -0.6 0.5
Ulcerative Colitis (UC) 0.0 0.0 0.0 0.1 0.1
Major Depression (MDD) 0.1 0.2 0.3 -0.1 0.6
Reaction Time 12.3 23.5 24.6 4.7 -5.0
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.6 0.0 1.3
Breast Cancer 0.2 0.5 0.9 0.0 1.0
Ovarian Cancer 0.0 0.0 0.1 -0.2 -0.2
Prostate Cancer 1.4 1.9 2.9 -1.0 1.7
Age at First Birth 0.7 1.0 1.4 -0.8 1.2
Bipolar Disorder (2011) 2.1 2.0 2.2 1.5 -1.4
Body Mass Index (BMI) (2010) 0.8 1.1 1.9 -1.4 0.6
Coronary Artery Disease (CAD) 0.2 0.3 0.4 -0.6 -0.3
Crohns Disease (2012) 0.1 0.1 0.2 -0.5 -0.0
Mean Putamen Volume 1.2 1.4 1.6 1.1 -1.3
Fasting Glucose 6.0 7.2 9.0 2.3 -3.0
HbA1C 0.0 0.1 0.1 0.1 -0.3
HDL Cholesterol 17.5 29.2 33.4 5.8 -5.0
LDL Cholesterol 5.7 9.0 11.4 -2.6 3.4
Lupus 0.0 0.0 0.1 0.2 -0.2
Neuroticism (2016) 3.5 5.1 6.8 -1.8 2.6
Primary Biliary Cirrhosis 4.6 6.5 7.0 2.5 -2.6
Rheumatoid Arthritis 2.6 3.6 4.7 -1.6 2.2
Schizophrenia (2014) 6.5 14.3 14.6 3.8 -3.8
Triglycerides 7.5 12.3 16.3 -2.9 4.0
Type 2 Diabetes (T2D) (2012) 1.5 1.8 2.2 1.5 -1.1
Ulcerative Colitis 0.3 0.5 0.7 -0.5 0.9
Blood Eosinophil Count 0.2 1.2 1.2 1.1 -1.1
Blood Platelet Count 2.8 32.1 36.4 5.3 -6.0
Blood Red Count 0.0 0.5 0.8 0.4 -0.9
Blood White Count 0.1 1.0 1.8 -1.4 0.5
Heel T-Score 29.8 237.0 289.0 13.6 -17.0
BMI 0.4 2.6 5.0 -2.2 0.3
Height 2.5 48.4 49.3 6.9 -7.0
Waist Hip Ratio (WHR) 0.2 1.1 2.1 1.4 -0.4
Systolic Blood Pressure 0.8 4.2 4.8 -1.9 2.2
Smoking Status 5.0 12.0 13.7 3.2 -3.7
Allergy or Eczema 0.2 0.4 0.5 0.6 0.7
Cardiovascular Disease 0.6 2.0 2.1 -1.4 1.4
Hypothyroidism (self reported) 0.4 1.0 1.9 0.2 -1.4
Respiratory disease 0.4 0.9 1.4 -0.7 1.2
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.6 -0.7 0.8
Lung FEV1/FVC ratio 0.1 0.7 0.9 -0.7 1.0
Lung FVC 2.0 10.0 10.0 3.1 -3.2
Neuroticism 4.9 11.7 15.4 -2.8 3.9
Chronotype (morning person) 0.2 0.6 0.8 0.6 -0.9
Hair Pigment 0.7 18.9 19.1 4.4 -4.3
Tanning 0.4 5.0 7.4 2.7 -1.6
Hand grip strength (left) 3.0 7.9 7.9 2.8 -2.8
Number of treatments/medications taken 4.1 7.3 9.1 -3.0 2.4
Average weekly spirits intake 0.3 0.4 0.7 -0.2 -0.8
Sensitivity / hurt feelings 6.7 11.5 12.5 -3.2 3.5
Frequency of depressed mood in last 2 weeks 4.8 6.7 9.9 -1.9 3.1
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.4 0.5
Relative age of first facial hair 1.7 3.4 3.5 1.8 -1.9
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.2 0.2 -1.1
Ever used hormone-replacement therapy (HRT) 4.6 5.9 7.8 -2.8 2.0
Ever had hysterectomy (womb removed) 2.8 3.1 3.7 -1.6 1.9
Systolic blood pressure, automated reading 1.0 2.9 4.4 -2.1 1.2
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.4 0.0 -0.6
Angina 2.5 3.3 4.0 -1.6 2.0
Medication for hormone replacement therapy 2.6 2.9 4.4 1.2 -2.1
Vitamin and mineral supplements 0.1 0.1 0.2 0.3 0.5
Supplements: Zinc 2.0 2.1 2.8 1.2 -1.7
Medication: Co-codamol 0.0 0.0 0.1 -0.2 0.0
Medication: Metformin 0.2 0.2 0.3 0.4 -0.5
Diabetes (father) 1.1 1.4 1.6 -1.1 1.3
Diabetes (mother) 0.4 0.5 0.7 -0.6 0.9
Severe depression (siblings) 3.2 3.6 3.8 2.0 -1.8
Pack years adult smoking proportion 1.5 2.2 2.5 1.4 -1.6
Impedance of leg (right) 0.5 2.3 3.6 1.0 1.9
Leg fat-free mass (left) 1.3 7.1 12.8 1.2 -3.6
Trunk fat percentage 0.6 2.5 3.6 -1.9 1.2
Hand grip strength (right) 1.5 4.2 4.5 2.0 -2.1
Townsend deprivation index at recruitment 0.0 0.0 0.0 0.2 0.0
Current tobacco smoking 1.9 3.1 3.8 1.9 -1.6
Average weekly fortified wine intake 0.8 0.9 1.3 -0.7 1.1
Maternal smoking around birth 0.5 0.7 0.8 0.9 -0.8
Fed-up feelings 7.9 14.3 15.9 -3.6 4.0
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 3.0 3.0 -1.7 1.7
Relative age voice broke 1.7 2.6 3.0 1.5 -1.7
Taking other prescription medications 0.3 0.5 0.8 0.3 -0.9
Age when periods started (menarche) 0.3 0.7 0.9 0.7 0.9
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.0 -0.9 1.0
Heel bone mineral density (BMD) T-score, automated (left) 20.0 45.3 57.9 5.7 -7.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 -0.2 0.4
Qualifications: CSEs or equivalent 0.3 0.5 0.5 -0.6 0.7
Serious illness, injury or assault to yourself 0.0 0.0 0.0 0.0 0.2
High blood pressure 4.4 12.4 14.1 -3.3 3.8
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.5 0.6 0.7
Multivitamins +/- minerals 0.1 0.2 0.3 -0.5 0.3
Stomach or abdominal pain in last month 0.7 0.9 1.3 1.1 -0.8
Supplements: Glucosamine 1.8 2.3 3.9 0.9 -2.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 0.3 -0.6
Medication: Atenolol 2.1 2.6 2.9 1.7 -1.5
Medication: Levothyroxine sodium 0.5 0.8 1.6 -1.3 0.0
Sitting height 4.3 30.2 35.8 5.0 -6.0
Chronic bronchitis/emphysema (father) 1.2 1.4 1.9 1.0 -1.4
High blood pressure (mother) 2.8 4.0 4.4 -2.1 1.9
Body mass index (BMI) 0.6 2.5 4.9 -2.2 0.4
Impedance of leg (left) 0.4 2.0 2.8 1.2 1.7
Leg predicted mass (left) 1.3 6.8 12.4 1.1 -3.5
Trunk fat mass 0.1 0.5 0.8 -0.9 -0.3
Waist circumference 0.5 2.0 3.3 -1.8 0.8
Number of incorrect matches in round 1.6 2.6 2.9 1.7 -1.5
Past tobacco smoking 1.5 2.8 4.5 -1.0 2.1
Alcohol usually taken with meals 1.1 1.8 2.4 -1.1 1.5
Nervous feelings 3.4 6.4 11.1 -1.3 3.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.2 -0.3 1.5
Hearing difficulty/problems with background noise 8.6 13.7 16.4 -3.3 4.0
Hair/balding pattern: Pattern 2 3.5 4.4 5.0 2.0 -2.2
Had menopause 0.3 0.4 0.5 0.4 -0.7
Had other major operations 0.1 0.1 0.2 0.4 0.1
Forced vital capacity (FVC) 4.0 15.4 15.4 3.9 -3.9
Heel bone mineral density (BMD) T-score, automated (right) 20.9 47.8 59.4 6.0 -7.7
Ever unenthusiastic/disinterested for a whole week 4.3 5.2 5.8 2.4 -2.2
Qualifications: None of the above 0.1 0.2 0.2 0.5 0.3
Financial difficulties in last 2 years 0.2 0.3 0.4 -0.4 0.6
Mouth/teeth dental problems 1.3 2.1 3.7 -1.9 0.6
Heart attack 0.0 0.0 0.1 0.1 -0.3
Allergy 0.1 0.2 0.2 -0.5 -0.5
Pain all over the body in last month 0.1 0.1 0.1 -0.3 -0.4
Diabetes (self-reported) 0.2 0.3 0.5 -0.7 0.0
Hayfever/allergic rhinitis (self-reported) 3.1 4.1 5.5 -1.6 2.4
Medication: Ramipril 0.0 0.0 0.0 -0.1 0.1
Medication: Simvastatin 0.9 1.4 1.8 -1.4 1.0
Fluid intelligence score 0.2 0.5 0.5 0.7 0.7
Illnesses of siblings 0.1 0.1 0.1 -0.4 0.3
Neuroticism score 3.2 6.6 8.9 -2.1 3.0
Weight 0.5 2.2 4.3 0.3 -2.1
Impedance of arm (right) 0.1 0.7 0.8 0.8 0.9
Arm fat percentage (right) 0.7 2.7 4.6 -2.1 1.0
Trunk fat-free mass 3.3 18.7 26.6 3.3 -5.2
Hip circumference 1.5 6.3 10.1 -3.2 1.6
Time employed in main current job 3.0 3.4 5.4 2.3 -1.2
Alcohol intake versus 10 years previously 0.2 0.3 0.5 0.7 -0.4
Father’s age at death 2.5 3.3 4.5 -1.4 2.1
Worrier / anxious feelings 0.2 0.4 0.8 0.1 0.9
Frequency of tiredness / lethargy in last 2 weeks 5.0 8.2 10.9 -2.3 3.3
Falls in the last year 0.2 0.2 0.4 0.2 -0.6
Hair/balding pattern: Pattern 3 4.0 6.0 6.5 -2.4 2.5
Number of live births 3.4 4.9 5.6 2.0 -2.4
Forced expiratory volume in 1-second (FEV1) 2.0 6.6 7.1 2.7 -2.5
Pulse rate 0.2 0.3 0.6 -0.2 -0.8
Happiness 1.6 2.0 2.2 -1.5 1.3
Noisy workplace 2.7 3.4 4.3 1.6 -2.1
Qualifications: A levels/AS levels or equivalent 2.7 5.9 6.8 -2.2 2.6
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 1.7 -0.8 1.3
Mouth/teeth dental problems: Dentures 1.0 1.7 2.3 1.5 -1.1
Asthma 1.7 3.3 3.8 -1.7 1.9
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.1 1.4 -0.9 1.2
Medication: Cholesterol lowering 0.0 0.0 0.0 -0.1 -0.2
Depression (self-reported) 0.0 0.0 0.1 -0.1 -0.3
Medication: Lansoprazole 1.0 1.1 1.5 -0.9 1.2
Prospective memory result 0.5 0.6 1.0 0.3 -1.0
Lung cancer (father) 3.9 4.5 5.5 2.3 -1.9
Illnesses of mother 0.2 0.3 0.3 0.5 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 2.8 9.0 10.1 3.2 -2.8
Pulse wave Arterial Stiffness index 0.2 0.2 0.3 -0.6 0.3
Impedance of arm (left) 0.1 0.7 1.2 0.4 1.1
Arm fat mass (right) 0.2 0.9 1.7 -1.3 -0.3
Trunk predicted mass 3.2 18.4 26.2 3.2 -5.1
Standing height 3.5 34.8 35.6 5.8 -6.0
Length of working week for main job 1.0 1.1 1.6 0.8 -1.3
Exposure to tobacco smoke at home 0.4 0.4 0.5 -0.6 0.7
Breastfed as a baby 2.1 2.6 3.7 1.2 -1.9
Tense / ‘highly strung’ 0.3 0.6 1.1 -0.2 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.5 0.9 -0.4 1.0
Hair/balding pattern: Pattern 4 3.1 7.5 10.2 -3.2 2.2
Birth weight of first child 0.1 0.1 0.2 0.4 -0.2
Peak expiratory flow (PEF) 0.6 1.3 1.7 1.0 -1.3
Pulse wave reflection index 0.2 0.2 0.2 -0.5 0.4
Ever highly irritable/argumentative for 2 days 0.8 1.0 1.6 0.6 -1.3
Loud music exposure frequency 0.0 0.0 0.1 -0.3 -0.1
Qualifications: O levels/GCSEs or equivalent 2.3 3.6 4.7 -1.6 2.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.9 0.9 0.4
Blood clot in the leg (DVT) 6.1 7.8 8.1 2.8 -2.8
Medication: Paracetamol 0.1 0.2 0.4 -0.6 0.3
Headache pain in last month 0.5 0.9 1.7 -0.2 1.3
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.4 1.2 -0.7
Glaucoma (self-reported) 1.0 1.2 1.7 1.3 -0.8
Gout (self-reported) 0.0 0.0 0.0 -0.2 -0.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.6 -0.7 -0.1
Medication: Amlodipine 0.8 1.2 1.2 -1.1 1.1
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.1 0.4
Birth weight 1.3 2.8 3.6 1.4 -1.9
Chronic bronchitis/emphysema (mother) 3.0 3.5 3.5 1.9 -1.9
High blood pressure (siblings) 0.0 0.1 0.1 0.3 -0.2
Forced vital capacity (FVC), Best measure 5.8 21.2 22.3 4.7 -4.5
Body fat percentage 0.8 3.1 4.4 -2.1 1.4
Leg fat percentage (right) 1.2 4.4 5.2 -2.3 1.9
Arm fat-free mass (right) 1.8 9.2 14.4 2.0 -3.8
Exposure to tobacco smoke outside home 2.7 3.5 5.2 -1.4 2.3
Comparative body size at age 10 0.4 1.1 1.4 -0.9 -1.2
Number of full brothers 0.8 1.0 1.7 0.5 -1.3
Worry too long after embarrassment 0.1 0.1 0.2 -0.2 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.2 0.5 -0.5
Wheeze or whistling in the chest in last year 0.4 0.7 1.0 1.0 -0.6
Number of children fathered 2.8 3.2 4.1 1.5 -2.0
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.3 -0.0 -0.6
Age at first live birth 2.3 4.1 4.4 -2.1 1.9
Pulse wave peak to peak time 0.5 0.6 0.8 0.9 -0.7
Health satisfaction 0.0 0.0 0.0 -0.1 0.1
Shortness of breath walking on level ground 1.9 2.2 2.9 -1.3 1.7
Qualifications: College or University degree 0.4 1.2 2.0 -1.4 0.6
Eye problems/disorders: None of the above 0.6 0.7 1.1 -0.5 1.0
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.0 1.0 -0.6
Emphysema/chronic bronchitis 0.4 0.4 0.6 0.8 -0.5
Medication for pain relief, constipation, heartburn 0.6 1.1 1.2 1.1 -1.0
Neck or shoulder pain in last month 0.2 0.3 0.3 -0.5 0.5
Medication: Blood pressure 1.3 2.3 3.3 -1.8 1.2
Angina (self-reported) 1.9 2.6 3.2 -1.4 1.8
Migraine (self-reported) 0.3 0.4 0.4 0.6 -0.7
Medication: Ibuprofen 1.6 2.0 2.1 -1.4 1.4
Medication: Allopurinol 0.4 0.6 1.0 -1.0 0.4
Medication: Omeprazole 0.1 0.1 0.1 -0.3 -0.1
Medication: Seretide 50 evohaler 0.6 0.7 0.8 0.8 -0.9
Mean time to correctly identify matches 14.6 27.9 28.8 5.2 -5.4
Heart disease (mother) 0.4 0.5 0.8 0.9 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 0.6 -0.5 0.8
Whole body fat mass 0.1 0.6 1.2 -1.1 -0.2
Leg fat mass (right) 0.2 0.8 1.6 -1.3 -0.0
Arm predicted mass (right) 1.9 9.9 15.4 2.1 -3.9
Pulse rate, automated reading 0.2 0.7 1.4 -0.3 -1.2
Alcohol intake frequency. 0.0 0.1 0.2 0.3 -0.4
Comparative height size at age 10 5.2 28.7 32.6 5.0 -5.7
Number of full sisters 1.0 1.3 1.9 0.8 -1.4
Suffer from ‘nerves’ 3.5 5.4 8.9 -1.4 3.0
Overall health rating 0.4 0.9 1.3 -1.1 0.7
Chest pain or discomfort 0.6 0.9 1.7 1.3 -0.4
Had major operations 2.5 2.9 3.9 -1.4 2.0
Age at last live birth 0.1 0.1 0.2 -0.5 0.0
Family relationship satisfaction 0.4 0.5 0.7 0.8 -0.6
Leg pain on walking 0.2 0.2 0.4 0.6 -0.2
Qualifications: NVQ or HND or HNC or equivalent 2.1 2.6 2.8 1.5 -1.7
Commuting to job workplace: Car/motor vehicle 3.0 3.4 4.2 2.0 -1.7
Illness, injury, bereavement, stress in last 2 years 0.0 0.1 0.1 -0.2 -0.3
Medication: Aspirin 0.0 0.0 0.0 -0.2 -0.1
Supplements: Vitamin C 1.1 1.3 1.5 1.2 -1.0
Knee pain experienced in last month 0.6 0.9 1.5 1.2 -0.5
Hypertension (Self-reported) 3.6 10.0 11.4 -2.9 3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.8 0.9 0.0
Illnesses of father: Heart disease 1.0 1.4 1.8 -1.3 1.0
Illnesses of siblings: Diabetes 0.2 0.3 0.4 -0.6 0.4
Smoking status: Previous 0.7 1.1 1.9 0.5 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 3.5 7.4 8.0 2.6 -2.8
Whole body fat-free mass 2.3 13.2 20.6 2.4 -4.5
Leg fat-free mass (right) 1.5 7.8 14.0 1.2 -3.7
Arm fat percentage (left) 1.0 4.1 6.6 -2.6 1.2
Average weekly red wine intake 0.2 0.4 0.7 -0.8 0.2
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.5 -0.3 0.7
Mood swings 2.8 5.1 7.4 -1.6 2.7
Loneliness, isolation 1.6 2.2 3.6 -0.8 1.9
Long-standing illness, disability or infirmity 1.2 1.8 2.6 1.0 -1.6
Ever had bowel cancer screening 0.0 0.0 0.1 0.1 -0.3
Diabetes diagnosed by doctor 0.1 0.1 0.2 -0.2 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 0.7 -0.2
Friendships satisfaction 0.3 0.3 0.5 0.5 -0.7
Qualifications: nursing, teaching 1.6 2.4 3.9 -2.0 1.0
Commuting to job workplace: Walk 1.3 1.4 1.6 -1.1 1.3
Eye problems/disorders: Cataract 0.4 0.4 0.9 0.0 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.6 0.6 -0.8
Medication for cholesterol 0.4 0.6 0.8 0.9 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 0.9 0.7 -1.0
Back pain experienced in last month 2.2 3.3 4.1 -1.5 2.0
Mineral and other dietary supplements 0.5 0.7 1.0 1.0 -0.7
Breast cancer (self-reported) 0.1 0.1 0.2 0.4 -0.1
Asthma (self-reported) 1.3 2.6 3.2 -1.4 1.8
Osteoporosis (self-reported) 5.3 6.5 8.3 -2.2 2.9
Osteoarthritis (self-reported) 0.5 0.6 1.1 -1.0 0.4
Medication: Aspirin 0.1 0.1 0.2 0.0 -0.4
Medication: Gliclazide 0.3 0.3 0.4 0.5 -0.6
Illnesses of father: None of the above (group 1) 1.9 2.3 3.3 1.8 -1.1
Smoking status: Current 1.9 3.1 4.0 2.0 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 2.4 1.5 -0.8
Whole body water mass 2.3 13.1 20.4 2.4 -4.5
Leg predicted mass (right) 1.5 7.9 14.2 1.3 -3.8
Arm fat mass (left) 0.2 0.9 1.5 -1.2 -0.5
Number of self-reported non-cancer illnesses 1.8 3.0 3.1 -1.7 1.8
Average weekly champagne plus white wine intake 1.1 1.5 2.9 1.7 -0.3
Miserableness 7.4 12.8 16.0 -3.1 4.0
Guilty feelings 0.0 0.0 0.0 -0.2 0.1
Wears glasses or contact lenses 0.3 0.3 0.7 -0.0 -0.8
Ever taken oral contraceptive pill 1.2 1.4 1.5 -1.2 1.1
Hearing aid user 0.1 0.1 0.1 -0.2 0.2
Mother’s age at death 2.0 2.6 3.9 -1.1 2.0
Financial situation satisfaction 0.0 0.0 0.0 0.2 0.2
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.8 0.9 -0.1
Commuting to job workplace: Public transport 0.6 0.7 0.9 -1.0 0.7
Eye problems/disorders: Glaucoma 1.7 2.1 3.0 1.7 -1.1
Medication: Blood pressure 2.0 3.7 5.2 -1.5 2.3
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.6 -0.8 0.2
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 -0.6 -0.3
High cholesterol (Self-reported) 0.3 0.5 0.6 -0.6 0.8
Medication: Bendroflumethiazide 1.7 2.5 3.1 -1.4 1.8
Medication: Paracetamol 0.1 0.1 0.2 -0.5 -0.1
Medication: Lisinopril 2.0 2.6 3.3 -1.4 1.8
Medication: Atorvastatin 0.2 0.2 0.4 0.0 -0.6
Illnesses of father: High blood pressure 0.5 0.6 1.0 1.0 -0.5
Alcohol drinker status: Never 0.3 0.3 0.4 -0.6 0.6
Ever smoked 1.3 2.3 3.5 1.1 -1.9
Basal metabolic rate 1.7 9.7 15.8 1.9 -4.0
Leg fat percentage (left) 0.9 3.3 4.4 -2.1 1.5
Arm fat-free mass (left) 1.6 8.0 12.5 1.9 -3.5
Number of operations (self-reported) 0.0 0.1 0.1 0.1 0.3
Average weekly beer plus cider intake 4.9 7.1 7.9 2.8 -2.5
Irritability 0.2 0.4 0.7 -0.4 0.8
Risk taking 1.8 2.6 3.3 1.4 -1.8
Ever had prostate specific antigen (PSA) test 2.6 3.0 3.5 -1.9 1.6
Fractured/broken bones in last 5 years 1.3 1.7 2.8 -0.8 1.7
Age started oral contraceptive pill 1.6 2.0 3.2 -0.9 1.8
Diastolic blood pressure, automated reading 0.1 0.4 0.6 -0.8 0.5
Ever depressed for a whole week 0.8 0.9 1.0 0.9 -1.0
Unable to work because of sickness or disability 0.9 1.1 1.8 0.6 -1.4
Commuting to job workplace: Cycle 0.6 0.8 1.4 -1.2 0.3
Myopia 3.4 4.9 5.8 2.4 -2.0
Vascular/heart problems diagnosed by doctor 3.6 9.9 10.9 3.0 -3.3
Cholesterol lowering medication 1.5 2.3 2.7 -1.3 1.6
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.1 -0.2 0.0
Pain experienced in last month 2.3 3.9 5.6 1.5 -2.4
Supplements: Calcium 0.9 0.9 1.0 -0.9 1.0
Basal cell carcinoma (self-reported) 1.0 1.2 1.4 -1.2 1.0
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.4 0.4 -0.6
Deep venous thrombosis (DVT) (self-reported) 6.9 8.9 9.2 2.9 -3.0
Heart disease (siblings) 2.0 2.5 2.7 1.6 -1.5
Alcohol drinker status: Previous 0.2 0.2 0.2 -0.5 0.4
Pack years of smoking 1.9 2.8 3.2 1.5 -1.8
Impedance of whole body 0.4 1.9 3.5 0.5 1.9
Leg fat mass (left) 0.1 0.6 0.9 -0.9 -0.5
Arm predicted mass (left) 1.5 7.4 11.4 1.8 -3.4