[Hub]/) : Traits : Forced vital capacity (FVC), Best measure : ← →

chr6:33,686,103-36,804,187

Best TWAS P=1.3e-20 · Best GWAS P=2.64e-31 conditioned to 2.17e-31

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	NTR	Blood	ZNF76	0.01	0.00	blup	424	0.00	3.8e-02	-6.3	9.3	1.3e-20	-0.17	0.12	0.51	TRUE
29	ROSMAP	Brain Pre-frontal Cortex	PACSIN1	0.09	0.00	blup	359	0.02	4.5e-04	4.0	7.0	2.6e-12	0.27	0.18	0.07	TRUE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	C6orf126	0.03	0.00	enet	8	0.01	1.8e-02	4.8	5.8	7.2e-09	0.04	0.01	0.36	TRUE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RPL10A	0.03	0.00	blup	54	0.02	6.0e-03	-8.3	-9.1	8.0e-20	0.03	0.01	0.85	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FANCE	0.03	0.02	bslmm	420	0.01	1.7e-02	-7.9	-8.8	8.6e-19	0.08	0.26	0.32	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	TCP11	0.03	0.03	blup	49	0.04	6.6e-08	-7.0	-8.6	6.9e-18	0.07	0.18	0.82	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TCP11	0.03	0.03	blup	49	0.03	3.5e-04	-8.2	-8.6	8.3e-18	0.05	0.05	0.88	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TCP11	0.03	0.02	blup	49	0.02	1.7e-03	-6.2	-8.3	1.3e-16	0.07	0.02	0.95	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	TCP11	0.03	0.02	blup	49	0.02	1.6e-03	-7.9	-8.2	1.6e-16	0.04	0.01	0.83	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	TCP11	0.05	0.04	blup	49	0.06	1.3e-07	-8.3	-8.2	2.3e-16	0.05	0.06	0.94	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	C6orf106	0.08	0.00	enet	15	0.05	2.5e-05	-6.0	8.2	2.5e-16	-0.05	0.01	0.74	FALSE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TCP11	0.08	0.11	lasso	2	0.11	3.4e-05	-7.9	-8.1	6.8e-16	0.01	0.06	0.76	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TCP11	0.03	0.00	blup	49	0.01	8.8e-03	-8.3	-8.0	1.0e-15	0.02	0.06	0.47	FALSE
47	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TCP11	0.05	0.07	lasso	2	0.07	1.9e-05	-7.9	-8.0	1.3e-15	0.01	0.09	0.83	FALSE
9	GTEx	Colon Transverse	RPL10A	0.12	0.05	lasso	4	0.05	2.5e-03	-7.0	-7.9	2.9e-15	-0.06	0.24	0.16	FALSE
7	GTEx	Cells Transformed fibroblasts	TEAD3	0.36	0.29	enet	27	0.32	8.4e-25	5.5	-7.7	1.2e-14	-0.09	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	RPL10A	0.02	0.02	lasso	2	0.02	3.8e-03	-7.7	-7.7	1.6e-14	-0.01	0.08	0.06	FALSE
36	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TCP11	0.07	0.01	enet	8	0.01	8.2e-02	-8.1	-7.6	2.2e-14	-0.02	0.04	0.52	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	C6orf81	0.05	0.00	blup	43	0.02	8.9e-04	5.4	-7.6	2.5e-14	0.03	0.02	0.34	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	TEAD3	0.15	0.06	lasso	5	0.08	2.5e-05	-6.6	-7.6	3.5e-14	-0.09	0.39	0.50	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	RPL10A	0.05	0.07	enet	4	0.04	1.2e-04	-7.2	-7.6	3.7e-14	-0.03	0.76	0.05	FALSE
4	GTEx	Artery Aorta	RPL10A	0.20	0.12	lasso	5	0.11	8.8e-07	-7.2	-7.4	1.3e-13	-0.04	0.96	0.01	FALSE
10	GTEx	Esophagus Mucosa	RPL10A	0.14	0.10	enet	17	0.09	2.1e-06	-7.0	-7.2	7.8e-13	-0.12	0.93	0.02	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPL10A	0.07	0.07	lasso	2	0.06	9.9e-08	-7.0	-7.2	8.8e-13	-0.04	0.99	0.00	FALSE
11	GTEx	Esophagus Muscularis	RPL10A	0.31	0.19	lasso	5	0.18	4.6e-11	-7.2	-7.1	1.1e-12	-0.01	1.00	0.00	FALSE
21	GTEx	Skin Sun Exposed Lower leg	C6orf106	0.09	0.04	enet	25	0.02	4.6e-03	-5.7	7.1	1.3e-12	0.04	0.38	0.02	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPL10A	0.09	0.03	enet	19	0.07	1.1e-07	-7.2	-7.0	1.8e-12	0.01	0.92	0.02	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	TCP11	0.03	0.03	lasso	3	0.04	3.8e-05	-7.0	-7.0	2.1e-12	0.13	0.11	0.62	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	DEF6	0.04	0.02	bslmm	421	0.02	1.8e-03	-8.0	6.8	8.6e-12	-0.18	0.11	0.86	FALSE
5	GTEx	Artery Tibial	C6orf106	0.07	0.02	lasso	4	0.02	8.8e-03	-6.4	6.8	9.6e-12	-0.13	0.10	0.05	FALSE
19	GTEx	Nerve Tibial	RPL10A	0.14	0.12	lasso	3	0.12	9.7e-09	-7.2	-6.8	1.1e-11	-0.01	1.00	0.00	FALSE
6	GTEx	Artery Tibial	RPL10A	0.11	0.08	lasso	2	0.09	1.5e-07	-7.0	-6.7	1.8e-11	-0.08	1.00	0.00	FALSE
25	METSIM	Adipose	RPL10A	0.18	0.13	lasso	15	0.13	3.4e-19	-7.2	-6.7	1.8e-11	0.00	1.00	0.00	FALSE
14	GTEx	Lung	RPL10A	0.21	0.09	enet	53	0.09	1.2e-07	-7.2	-6.7	1.9e-11	-0.03	0.94	0.01	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	C6orf106	0.30	0.26	bslmm	372	0.33	9.3e-44	4.0	6.5	5.8e-11	0.00	1.00	0.00	FALSE
22	GTEx	Testis	ZNF76	0.15	0.14	enet	8	0.12	4.4e-06	-5.8	6.5	6.4e-11	-0.02	0.48	0.50	FALSE
17	GTEx	Nerve Tibial	DEF6	0.15	0.00	lasso	8	0.00	1.6e-01	-6.3	6.5	8.8e-11	-0.01	0.17	0.06	FALSE
32	YFS	Blood	RPL10A	0.24	0.11	lasso	11	0.13	4.4e-39	-7.2	-6.4	1.3e-10	-0.01	1.00	0.00	FALSE
33	YFS	Blood	ZNF76	0.05	0.08	lasso	4	0.07	6.7e-23	-6.3	6.2	4.3e-10	-0.17	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	RPL10A	0.06	0.02	enet	27	0.03	2.6e-03	-6.1	-5.9	3.5e-09	-0.10	0.31	0.08	FALSE
12	GTEx	Heart Atrial Appendage	MAPK13	0.12	0.00	lasso	5	0.00	3.1e-01	-5.8	5.8	5.0e-09	0.01	0.06	0.17	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF76	0.03	0.02	lasso	3	0.02	3.5e-03	-5.6	5.8	6.9e-09	-0.06	0.17	0.45	FALSE
23	GTEx	Thyroid	RPL10A	0.16	0.09	lasso	11	0.07	8.9e-06	-5.6	-5.7	1.1e-08	-0.13	0.88	0.01	FALSE
15	GTEx	Muscle Skeletal	UHRF1BP1	0.34	0.34	enet	45	0.39	4.3e-40	-3.1	-5.7	1.3e-08	0.14	1.00	0.00	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	ZNF76	0.04	0.00	blup	424	0.02	2.1e-03	-6.3	5.7	1.5e-08	-0.22	0.49	0.11	FALSE
24	GTEx	Whole Blood	DEF6	0.14	0.05	lasso	4	0.03	9.9e-04	-6.0	5.6	1.9e-08	-0.14	0.83	0.04	FALSE
16	GTEx	Muscle Skeletal	RPL10A	0.10	0.05	enet	17	0.04	3.9e-05	-7.1	-5.6	2.3e-08	-0.04	0.68	0.08	FALSE
3	GTEx	Adrenal Gland	UHRF1BP1	0.32	0.26	enet	33	0.33	1.3e-12	-3.1	-5.6	2.7e-08	0.09	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZNF76	0.08	0.05	lasso	10	0.07	4.9e-04	-6.8	-5.5	3.7e-08	0.06	0.03	0.55	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	SCUBE3	0.03	0.01	blup	62	0.03	8.9e-04	-6.8	5.4	5.4e-08	-0.10	0.06	0.57	FALSE
18	GTEx	Nerve Tibial	C6orf106	0.11	0.07	enet	17	0.07	1.3e-05	3.7	5.3	9.7e-08	0.03	0.71	0.02	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C6orf106	0.04	0.01	blup	68	0.01	2.4e-02	3.9	5.2	2.6e-07	0.08	0.03	0.20	FALSE
8	GTEx	Cells Transformed fibroblasts	RPS10	0.12	0.05	lasso	4	0.06	4.5e-05	5.3	5.1	2.8e-07	0.09	0.95	0.04	FALSE
13	GTEx	Heart Left Ventricle	UHRF1BP1	0.23	0.12	lasso	7	0.22	1.2e-11	-3.2	-5.1	2.8e-07	0.10	1.00	0.00	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	RPL10A	0.30	0.18	bslmm	409	0.19	2.6e-24	-7.0	-5.1	2.9e-07	0.12	1.00	0.00	FALSE