[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), predicted : ← →

chr10:103,527,782-105,275,242

Best TWAS P=6.38e-11 · Best GWAS P=2.67e-08 conditioned to 0.283

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	3.8	5.7	1.5e-08	-0.63	0.10	0.46	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ARL3	0.03	0.03	lasso	6	0.03	1.8e-04	-5.5	5.6	1.6e-08	-0.81	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	WBP1L	0.05	0.00	enet	8	0.00	5.3e-01	-5.4	5.9	2.9e-09	-0.82	0.04	0.69	FALSE
4	GTEx	Adrenal Gland	TMEM180	0.19	0.15	enet	12	0.09	3.5e-04	-5.5	-6.5	6.4e-11	0.92	0.02	0.97	TRUE
5	GTEx	Artery Coronary	TMEM180	0.14	0.05	enet	13	0.04	2.4e-02	-5.6	-5.7	1.5e-08	0.94	0.03	0.90	FALSE
6	GTEx	Brain Cerebellar Hemisphere	TMEM180	0.23	0.23	lasso	10	0.10	1.3e-03	-5.5	-5.4	6.9e-08	0.95	0.03	0.96	FALSE
7	GTEx	Brain Cerebellum	TMEM180	0.25	0.29	enet	11	0.26	3.5e-08	-5.5	-5.5	3.6e-08	0.98	0.02	0.97	FALSE
8	GTEx	Brain Hypothalamus	TMEM180	0.21	0.20	lasso	5	0.12	8.5e-04	-5.3	-5.1	2.6e-07	0.92	0.03	0.91	FALSE
9	GTEx	Breast Mammary Tissue	TMEM180	0.17	0.16	enet	9	0.17	3.6e-09	-5.3	-5.6	2.5e-08	0.97	0.02	0.98	FALSE
10	GTEx	Breast Mammary Tissue (Male)	TMEM180	0.26	0.15	lasso	17	0.17	1.0e-04	-5.5	-5.3	9.7e-08	0.94	0.03	0.91	FALSE
11	GTEx	Colon Sigmoid	TMEM180	0.32	0.41	lasso	3	0.38	1.5e-14	-5.5	-5.6	2.2e-08	0.99	0.02	0.98	FALSE
12	GTEx	Colon Transverse	TMEM180	0.16	0.15	enet	11	0.13	1.2e-06	-5.5	-5.5	3.8e-08	0.98	0.02	0.98	FALSE
13	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	-5.3	-5.7	1.1e-08	0.74	0.05	0.91	FALSE
14	GTEx	Esophagus Muscularis	TMEM180	0.23	0.22	enet	19	0.19	1.6e-11	-5.3	-5.4	5.3e-08	0.96	0.02	0.98	FALSE
15	GTEx	Heart Left Ventricle	TMEM180	0.19	0.17	enet	14	0.17	3.7e-09	-5.5	-5.2	1.7e-07	0.94	0.02	0.98	FALSE
16	GTEx	Lung	TMEM180	0.12	0.11	lasso	4	0.13	5.1e-10	-5.6	-5.3	9.6e-08	0.95	0.02	0.98	FALSE
17	GTEx	Nerve Tibial	TMEM180	0.32	0.30	enet	16	0.32	2.0e-23	-5.5	-5.5	3.5e-08	0.98	0.02	0.98	FALSE
18	GTEx	Pituitary	TMEM180	0.36	0.23	enet	12	0.20	1.1e-05	-5.5	-5.4	5.5e-08	0.96	0.02	0.96	FALSE
19	GTEx	Spleen	TMEM180	0.16	0.21	lasso	3	0.05	2.6e-02	-5.3	-5.2	1.8e-07	0.94	0.03	0.86	FALSE
20	GTEx	Stomach	TMEM180	0.33	0.22	lasso	8	0.21	2.2e-10	-5.5	-5.5	3.1e-08	0.97	0.02	0.98	FALSE
21	GTEx	Thyroid	TMEM180	0.31	0.38	enet	20	0.42	8.1e-35	-5.5	-5.3	1.3e-07	0.95	0.02	0.98	FALSE
22	METSIM	Adipose	TMEM180	0.28	0.25	enet	33	0.26	2.5e-39	-5.3	-5.8	7.9e-09	0.94	0.03	0.97	FALSE
23	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	-5.3	6.3	2.5e-10	-0.90	0.02	0.98	FALSE
24	NTR	Blood	TRIM8	0.02	0.01	enet	11	0.01	2.1e-03	-5.3	5.2	2.4e-07	-0.80	0.04	0.95	FALSE
25	YFS	Blood	TRIM8	0.04	0.04	lasso	6	0.05	1.2e-15	-5.4	5.5	4.7e-08	-0.80	0.03	0.97	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACTR1A	0.02	0.02	lasso	5	0.02	4.6e-03	-5.4	5.4	5.4e-08	-0.98	0.02	0.79	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUFU	0.03	0.03	lasso	1	0.03	2.0e-04	-5.2	-5.2	1.7e-07	0.95	0.04	0.96	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	C10orf95	0.02	0.03	lasso	2	0.02	4.7e-03	-5.6	-5.6	2.5e-08	1.00	0.01	0.93	FALSE