Best TWAS P=1.47e-14 · Best GWAS P=5.82e-16 conditioned to 0.0877
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HIP1R | 0.06 | 0.02 | lasso | 6 | 0.04 | 1.9e-05 | -6.3 | -6.4 | 1.5e-10 | 0.09 | 0.18 | 0.02 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CCDC92 | 0.23 | 0.04 | enet | 27 | 0.16 | 6.9e-13 | -3.8 | 6.4 | 1.5e-10 | -0.09 | 0.05 | 0.94 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | RP11-380L11.3 | 0.09 | 0.03 | lasso | 3 | 0.03 | 1.4e-03 | 4.6 | 6.3 | 3.6e-10 | -0.07 | 0.09 | 0.86 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | CCDC92 | 0.19 | 0.02 | lasso | 8 | 0.09 | 3.3e-05 | 4.7 | 7.1 | 1.7e-12 | -0.12 | 0.06 | 0.91 | TRUE |
| 5 | GTEx | Adipose Visceral Omentum | RP11-380L11.3 | 0.15 | 0.03 | lasso | 5 | 0.01 | 1.4e-01 | 4.5 | 6.7 | 1.6e-11 | -0.08 | 0.04 | 0.74 | TRUE |
| 6 | GTEx | Artery Tibial | PITPNM2 | 0.11 | 0.05 | lasso | 4 | 0.04 | 2.7e-04 | -4.8 | 5.2 | 1.8e-07 | 0.00 | 0.60 | 0.16 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Female) | C12orf65 | 0.06 | 0.00 | enet | 13 | -0.01 | 6.5e-01 | -3.9 | -6.0 | 2.0e-09 | 0.27 | 0.05 | 0.06 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | BCL7A | 0.06 | 0.01 | lasso | 4 | 0.01 | 3.1e-02 | 3.7 | -5.9 | 4.5e-09 | 0.24 | 0.09 | 0.05 | TRUE |
| 9 | GTEx | Colon Transverse | MLXIP | 0.20 | 0.18 | enet | 23 | 0.14 | 5.8e-07 | 6.1 | 5.7 | 1.1e-08 | -0.17 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Colon Transverse | SNRNP35 | 0.18 | 0.02 | lasso | 8 | 0.04 | 6.5e-03 | -4.8 | 6.7 | 2.5e-11 | -0.16 | 0.04 | 0.47 | TRUE |
| 11 | GTEx | Esophagus Mucosa | KDM2B | 0.11 | 0.04 | enet | 22 | 0.10 | 4.1e-07 | 2.6 | 6.0 | 1.6e-09 | -0.10 | 0.91 | 0.01 | TRUE |
| 12 | GTEx | Esophagus Mucosa | HIP1R | 0.21 | 0.05 | lasso | 5 | 0.07 | 1.5e-05 | 4.5 | 7.7 | 1.5e-14 | -0.21 | 0.47 | 0.26 | TRUE |
| 13 | GTEx | Heart Atrial Appendage | RP11-380L11.4 | 0.18 | 0.11 | lasso | 7 | 0.12 | 6.5e-06 | 4.7 | 5.5 | 4.7e-08 | -0.07 | 0.09 | 0.87 | FALSE |
| 14 | GTEx | Lung | CCDC92 | 0.14 | 0.00 | enet | 10 | 0.01 | 1.1e-01 | 5.3 | 6.0 | 1.8e-09 | -0.08 | 0.02 | 0.89 | FALSE |
| 15 | GTEx | Nerve Tibial | CCDC92 | 0.16 | 0.01 | enet | 6 | 0.04 | 6.7e-04 | 3.5 | 5.3 | 1.1e-07 | -0.10 | 0.09 | 0.47 | FALSE |
| 16 | GTEx | Nerve Tibial | KNTC1 | 0.12 | 0.05 | lasso | 5 | 0.05 | 1.9e-04 | -5.1 | -5.6 | 2.8e-08 | 0.31 | 0.53 | 0.03 | FALSE |
| 17 | GTEx | Thyroid | CCDC92 | 0.06 | 0.03 | lasso | 3 | 0.02 | 1.1e-02 | 4.6 | 5.8 | 5.6e-09 | -0.08 | 0.08 | 0.84 | FALSE |
| 18 | GTEx | Whole Blood | DDX55 | 0.13 | 0.04 | enet | 13 | 0.06 | 3.3e-06 | -3.9 | 5.2 | 1.7e-07 | -0.17 | 0.22 | 0.27 | FALSE |
| 19 | METSIM | Adipose | ABCB9 | 0.04 | 0.03 | enet | 19 | 0.03 | 7.7e-05 | -6.3 | -6.8 | 9.5e-12 | 0.38 | 0.08 | 0.65 | FALSE |
| 20 | METSIM | Adipose | CCDC92 | 0.10 | 0.01 | bslmm | 435 | 0.06 | 5.5e-10 | -2.9 | 5.9 | 3.2e-09 | -0.08 | 0.04 | 0.95 | FALSE |
| 21 | METSIM | Adipose | RP11-214K3.24 | 0.05 | 0.03 | bslmm | 444 | 0.02 | 2.7e-04 | 3.7 | 5.8 | 5.2e-09 | -0.07 | 0.11 | 0.79 | FALSE |
| 22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DNAH10 | 0.11 | 0.03 | blup | 99 | 0.05 | 8.2e-11 | 5.0 | 5.3 | 1.4e-07 | -0.05 | 0.03 | 0.96 | FALSE |
| 23 | The Cancer Genome Atlas | Colon Adenocarcinoma | MLXIP | 0.06 | 0.04 | lasso | 7 | 0.02 | 2.7e-02 | 6.0 | 6.0 | 2.6e-09 | -0.17 | 0.02 | 0.94 | FALSE |
| 24 | The Cancer Genome Atlas | Rectum Adenocarcinoma | MLXIP | 0.18 | 0.14 | lasso | 4 | 0.13 | 5.1e-04 | 5.3 | 5.7 | 1.4e-08 | -0.16 | 0.02 | 0.89 | FALSE |
| 25 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MLXIP | 0.06 | 0.02 | blup | 68 | 0.04 | 1.2e-03 | 6.0 | 7.2 | 7.8e-13 | -0.23 | 0.02 | 0.88 | TRUE |
| 26 | The Cancer Genome Atlas | Thyroid Carcinoma | VPS33A | 0.06 | 0.00 | enet | 8 | 0.03 | 9.6e-04 | 4.1 | -5.3 | 1.2e-07 | 0.20 | 0.10 | 0.88 | FALSE |