[Hub]/) : Traits : Body mass index (BMI) :

chr2:24,324,172-26,088,769

Best TWAS P=8.34e-52 · Best GWAS P=3.2e-48 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ADCY3 0.16 0.12 lasso 10 0.14 3.2e-17 14.2 -15.1 8.3e-52 -0.87 0.01 0.99 TRUE
2 CommonMind Brain Pre-frontal Cortex CENPO 0.07 0.03 bslmm 322 0.03 7.0e-05 7.8 -11.1 1.7e-28 -0.49 0.46 0.28 TRUE
3 GTEx Adipose Subcutaneous ADCY3 0.07 0.04 lasso 6 0.01 3.2e-02 13.3 12.7 3.8e-37 0.86 0.07 0.91 FALSE
4 GTEx Adipose Subcutaneous RP11-443B20.1 0.04 0.00 enet 10 0.00 1.2e-01 7.8 10.8 4.6e-27 0.81 0.04 0.90 FALSE
5 GTEx Adrenal Gland PTRHD1 0.32 0.28 lasso 3 0.26 8.3e-10 -7.4 7.8 4.8e-15 0.41 0.98 0.00 FALSE
6 GTEx Artery Coronary DNAJC27 0.12 0.03 lasso 7 0.00 2.4e-01 4.2 6.6 3.2e-11 0.46 0.14 0.22 FALSE
7 GTEx Artery Tibial ADCY3 0.21 0.14 lasso 6 0.15 4.3e-12 12.3 13.6 2.7e-42 0.69 0.98 0.02 FALSE
8 GTEx Artery Tibial RP11-443B20.1 0.17 0.08 enet 40 0.09 8.2e-08 12.3 12.3 5.6e-35 0.59 0.45 0.51 TRUE
9 GTEx Cells EBV-transformed lymphocytes ADCY3 0.25 0.23 enet 10 0.12 9.2e-05 13.3 -11.9 1.7e-32 -0.84 0.02 0.97 FALSE
10 GTEx Cells EBV-transformed lymphocytes RP11-443B20.1 0.13 0.13 enet 9 0.05 9.2e-03 13.3 -13.9 3.7e-44 -0.93 0.01 0.97 TRUE
11 GTEx Nerve Tibial ADCY3 0.09 0.05 enet 6 0.03 2.2e-03 12.3 -15.0 4.3e-51 -0.91 0.01 0.99 FALSE
12 GTEx Nerve Tibial RP11-443B20.1 0.07 0.03 enet 6 0.02 1.1e-02 12.3 -14.4 7.6e-47 -0.81 0.03 0.96 FALSE
13 GTEx Whole Blood DNAJC27 0.08 0.10 lasso 1 0.10 2.2e-09 13.0 13.0 1.7e-38 0.80 0.90 0.10 TRUE
14 GTEx Whole Blood ADCY3 0.23 0.24 enet 24 0.27 5.5e-25 13.2 14.4 7.6e-47 0.86 1.00 0.00 FALSE
15 GTEx Whole Blood RP11-443B20.1 0.21 0.17 enet 32 0.20 1.8e-18 13.0 14.7 5.0e-49 0.86 0.78 0.22 FALSE
16 METSIM Adipose EFR3B 0.04 0.00 bslmm 357 0.00 9.7e-02 -2.7 -8.6 1.3e-17 -0.37 0.06 0.08 FALSE
17 METSIM Adipose POMC 0.18 0.06 lasso 9 0.09 5.5e-13 -2.7 -5.8 7.0e-09 -0.16 1.00 0.00 TRUE
18 ROSMAP Brain Pre-frontal Cortex ADCY3 0.17 0.26 enet 32 0.26 6.8e-33 13.2 -14.5 1.0e-47 -0.89 0.81 0.19 FALSE
19 ROSMAP Brain Pre-frontal Cortex CENPO 0.08 0.04 enet 5 0.05 2.6e-07 -5.8 -7.1 1.6e-12 -0.36 1.00 0.00 FALSE
20 YFS Blood ADCY3 0.07 0.02 bslmm 343 0.04 7.3e-14 14.6 -8.6 1.3e-17 -0.61 0.00 1.00 FALSE
21 YFS Blood DNAJC27 0.07 0.04 blup 333 0.05 3.1e-17 4.2 -5.1 2.9e-07 -0.22 1.00 0.00 TRUE
22 YFS Blood POMC 0.35 0.05 enet 71 0.19 5.7e-59 -10.8 -9.7 2.2e-22 -0.31 1.00 0.00 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma ADCY3 0.05 0.03 blup 81 0.03 5.0e-07 1.7 -7.1 1.0e-12 -0.50 0.64 0.31 FALSE
24 The Cancer Genome Atlas Breast Invasive Carcinoma POMC 0.08 0.05 lasso 3 0.06 2.6e-12 -3.0 -7.9 2.9e-15 -0.20 0.63 0.37 FALSE
25 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma POMC 0.06 0.00 enet 12 0.03 9.3e-05 -3.0 -8.1 5.4e-16 -0.27 0.01 0.62 TRUE
26 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EFR3B 0.03 0.05 lasso 1 0.04 1.9e-05 -11.6 -11.6 3.6e-31 -0.67 0.56 0.06 FALSE
27 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma POMC 0.16 0.05 blup 39 0.11 2.4e-12 -10.8 -6.8 7.3e-12 -0.22 0.00 1.00 FALSE
28 The Cancer Genome Atlas Brain Lower Grade Glioma ADCY3 0.03 0.02 blup 81 0.02 7.1e-04 8.6 -12.7 4.3e-37 -0.87 0.04 0.93 FALSE
29 The Cancer Genome Atlas Lung Adenocarcinoma DNAJC27 0.05 0.01 blup 46 0.04 3.2e-05 4.2 -8.4 5.1e-17 -0.55 0.35 0.60 FALSE
30 The Cancer Genome Atlas Lung Adenocarcinoma NCOA1 0.02 0.01 blup 77 0.01 1.2e-02 -5.0 -6.2 4.6e-10 -0.23 0.03 0.76 FALSE
31 The Cancer Genome Atlas Lung Adenocarcinoma POMC 0.14 0.04 enet 7 0.08 5.3e-10 -3.0 -8.6 6.1e-18 -0.22 0.10 0.89 TRUE
32 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma POMC 0.19 0.01 blup 38 0.05 1.5e-04 -10.8 -8.9 3.8e-19 -0.33 0.00 0.85 FALSE
33 The Cancer Genome Atlas Pancreatic Adenocarcinoma POMC 0.22 0.05 blup 37 0.03 2.1e-02 -3.6 -7.5 6.7e-14 -0.12 0.01 0.10 TRUE
34 The Cancer Genome Atlas Prostate Adenocarcinoma POMC 0.11 0.08 enet 7 0.09 1.6e-09 -3.0 -8.9 6.2e-19 -0.24 0.13 0.87 FALSE
35 The Cancer Genome Atlas Stomach Adenocarcinoma POMC 0.14 0.00 blup 40 0.02 2.2e-02 -3.6 -6.9 7.0e-12 -0.14 0.00 0.62 TRUE