Best TWAS P=8.34e-52 · Best GWAS P=3.2e-48 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADCY3 | 0.16 | 0.12 | lasso | 10 | 0.14 | 3.2e-17 | 14.2 | -15.1 | 8.3e-52 | -0.87 | 0.01 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | CENPO | 0.07 | 0.03 | bslmm | 322 | 0.03 | 7.0e-05 | 7.8 | -11.1 | 1.7e-28 | -0.49 | 0.46 | 0.28 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | ADCY3 | 0.07 | 0.04 | lasso | 6 | 0.01 | 3.2e-02 | 13.3 | 12.7 | 3.8e-37 | 0.86 | 0.07 | 0.91 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | RP11-443B20.1 | 0.04 | 0.00 | enet | 10 | 0.00 | 1.2e-01 | 7.8 | 10.8 | 4.6e-27 | 0.81 | 0.04 | 0.90 | FALSE |
| 5 | GTEx | Adrenal Gland | PTRHD1 | 0.32 | 0.28 | lasso | 3 | 0.26 | 8.3e-10 | -7.4 | 7.8 | 4.8e-15 | 0.41 | 0.98 | 0.00 | FALSE |
| 6 | GTEx | Artery Coronary | DNAJC27 | 0.12 | 0.03 | lasso | 7 | 0.00 | 2.4e-01 | 4.2 | 6.6 | 3.2e-11 | 0.46 | 0.14 | 0.22 | FALSE |
| 7 | GTEx | Artery Tibial | ADCY3 | 0.21 | 0.14 | lasso | 6 | 0.15 | 4.3e-12 | 12.3 | 13.6 | 2.7e-42 | 0.69 | 0.98 | 0.02 | FALSE |
| 8 | GTEx | Artery Tibial | RP11-443B20.1 | 0.17 | 0.08 | enet | 40 | 0.09 | 8.2e-08 | 12.3 | 12.3 | 5.6e-35 | 0.59 | 0.45 | 0.51 | TRUE |
| 9 | GTEx | Cells EBV-transformed lymphocytes | ADCY3 | 0.25 | 0.23 | enet | 10 | 0.12 | 9.2e-05 | 13.3 | -11.9 | 1.7e-32 | -0.84 | 0.02 | 0.97 | FALSE |
| 10 | GTEx | Cells EBV-transformed lymphocytes | RP11-443B20.1 | 0.13 | 0.13 | enet | 9 | 0.05 | 9.2e-03 | 13.3 | -13.9 | 3.7e-44 | -0.93 | 0.01 | 0.97 | TRUE |
| 11 | GTEx | Nerve Tibial | ADCY3 | 0.09 | 0.05 | enet | 6 | 0.03 | 2.2e-03 | 12.3 | -15.0 | 4.3e-51 | -0.91 | 0.01 | 0.99 | FALSE |
| 12 | GTEx | Nerve Tibial | RP11-443B20.1 | 0.07 | 0.03 | enet | 6 | 0.02 | 1.1e-02 | 12.3 | -14.4 | 7.6e-47 | -0.81 | 0.03 | 0.96 | FALSE |
| 13 | GTEx | Whole Blood | DNAJC27 | 0.08 | 0.10 | lasso | 1 | 0.10 | 2.2e-09 | 13.0 | 13.0 | 1.7e-38 | 0.80 | 0.90 | 0.10 | TRUE |
| 14 | GTEx | Whole Blood | ADCY3 | 0.23 | 0.24 | enet | 24 | 0.27 | 5.5e-25 | 13.2 | 14.4 | 7.6e-47 | 0.86 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Whole Blood | RP11-443B20.1 | 0.21 | 0.17 | enet | 32 | 0.20 | 1.8e-18 | 13.0 | 14.7 | 5.0e-49 | 0.86 | 0.78 | 0.22 | FALSE |
| 16 | METSIM | Adipose | EFR3B | 0.04 | 0.00 | bslmm | 357 | 0.00 | 9.7e-02 | -2.7 | -8.6 | 1.3e-17 | -0.37 | 0.06 | 0.08 | FALSE |
| 17 | METSIM | Adipose | POMC | 0.18 | 0.06 | lasso | 9 | 0.09 | 5.5e-13 | -2.7 | -5.8 | 7.0e-09 | -0.16 | 1.00 | 0.00 | TRUE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | ADCY3 | 0.17 | 0.26 | enet | 32 | 0.26 | 6.8e-33 | 13.2 | -14.5 | 1.0e-47 | -0.89 | 0.81 | 0.19 | FALSE |
| 19 | ROSMAP | Brain Pre-frontal Cortex | CENPO | 0.08 | 0.04 | enet | 5 | 0.05 | 2.6e-07 | -5.8 | -7.1 | 1.6e-12 | -0.36 | 1.00 | 0.00 | FALSE |
| 20 | YFS | Blood | ADCY3 | 0.07 | 0.02 | bslmm | 343 | 0.04 | 7.3e-14 | 14.6 | -8.6 | 1.3e-17 | -0.61 | 0.00 | 1.00 | FALSE |
| 21 | YFS | Blood | DNAJC27 | 0.07 | 0.04 | blup | 333 | 0.05 | 3.1e-17 | 4.2 | -5.1 | 2.9e-07 | -0.22 | 1.00 | 0.00 | TRUE |
| 22 | YFS | Blood | POMC | 0.35 | 0.05 | enet | 71 | 0.19 | 5.7e-59 | -10.8 | -9.7 | 2.2e-22 | -0.31 | 1.00 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADCY3 | 0.05 | 0.03 | blup | 81 | 0.03 | 5.0e-07 | 1.7 | -7.1 | 1.0e-12 | -0.50 | 0.64 | 0.31 | FALSE |
| 24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | POMC | 0.08 | 0.05 | lasso | 3 | 0.06 | 2.6e-12 | -3.0 | -7.9 | 2.9e-15 | -0.20 | 0.63 | 0.37 | FALSE |
| 25 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | POMC | 0.06 | 0.00 | enet | 12 | 0.03 | 9.3e-05 | -3.0 | -8.1 | 5.4e-16 | -0.27 | 0.01 | 0.62 | TRUE |
| 26 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EFR3B | 0.03 | 0.05 | lasso | 1 | 0.04 | 1.9e-05 | -11.6 | -11.6 | 3.6e-31 | -0.67 | 0.56 | 0.06 | FALSE |
| 27 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | POMC | 0.16 | 0.05 | blup | 39 | 0.11 | 2.4e-12 | -10.8 | -6.8 | 7.3e-12 | -0.22 | 0.00 | 1.00 | FALSE |
| 28 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY3 | 0.03 | 0.02 | blup | 81 | 0.02 | 7.1e-04 | 8.6 | -12.7 | 4.3e-37 | -0.87 | 0.04 | 0.93 | FALSE |
| 29 | The Cancer Genome Atlas | Lung Adenocarcinoma | DNAJC27 | 0.05 | 0.01 | blup | 46 | 0.04 | 3.2e-05 | 4.2 | -8.4 | 5.1e-17 | -0.55 | 0.35 | 0.60 | FALSE |
| 30 | The Cancer Genome Atlas | Lung Adenocarcinoma | NCOA1 | 0.02 | 0.01 | blup | 77 | 0.01 | 1.2e-02 | -5.0 | -6.2 | 4.6e-10 | -0.23 | 0.03 | 0.76 | FALSE |
| 31 | The Cancer Genome Atlas | Lung Adenocarcinoma | POMC | 0.14 | 0.04 | enet | 7 | 0.08 | 5.3e-10 | -3.0 | -8.6 | 6.1e-18 | -0.22 | 0.10 | 0.89 | TRUE |
| 32 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | POMC | 0.19 | 0.01 | blup | 38 | 0.05 | 1.5e-04 | -10.8 | -8.9 | 3.8e-19 | -0.33 | 0.00 | 0.85 | FALSE |
| 33 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | POMC | 0.22 | 0.05 | blup | 37 | 0.03 | 2.1e-02 | -3.6 | -7.5 | 6.7e-14 | -0.12 | 0.01 | 0.10 | TRUE |
| 34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POMC | 0.11 | 0.08 | enet | 7 | 0.09 | 1.6e-09 | -3.0 | -8.9 | 6.2e-19 | -0.24 | 0.13 | 0.87 | FALSE |
| 35 | The Cancer Genome Atlas | Stomach Adenocarcinoma | POMC | 0.14 | 0.00 | blup | 40 | 0.02 | 2.2e-02 | -3.6 | -6.9 | 7.0e-12 | -0.14 | 0.00 | 0.62 | TRUE |