[Hub]/) : Traits : Body mass index (BMI) : ← →

chr2:24,324,172-26,088,769

Best TWAS P=8.34e-52 · Best GWAS P=3.2e-48 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	14.2	-15.1	8.3e-52	-0.87	0.01	0.99	TRUE
10	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	13.3	-13.9	3.7e-44	-0.93	0.01	0.97	TRUE
13	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	13.0	13.0	1.7e-38	0.80	0.90	0.10	TRUE
8	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	12.3	12.3	5.6e-35	0.59	0.45	0.51	TRUE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	7.8	-11.1	1.7e-28	-0.49	0.46	0.28	TRUE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	POMC	0.14	0.04	enet	7	0.08	5.3e-10	-3.0	-8.6	6.1e-18	-0.22	0.10	0.89	TRUE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POMC	0.06	0.00	enet	12	0.03	9.3e-05	-3.0	-8.1	5.4e-16	-0.27	0.01	0.62	TRUE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-3.6	-7.5	6.7e-14	-0.12	0.01	0.10	TRUE
35	The Cancer Genome Atlas	Stomach Adenocarcinoma	POMC	0.14	0.00	blup	40	0.02	2.2e-02	-3.6	-6.9	7.0e-12	-0.14	0.00	0.62	TRUE
17	METSIM	Adipose	POMC	0.18	0.06	lasso	9	0.09	5.5e-13	-2.7	-5.8	7.0e-09	-0.16	1.00	0.00	TRUE
21	YFS	Blood	DNAJC27	0.07	0.04	blup	333	0.05	3.1e-17	4.2	-5.1	2.9e-07	-0.22	1.00	0.00	TRUE
11	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	12.3	-15.0	4.3e-51	-0.91	0.01	0.99	FALSE
15	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	13.0	14.7	5.0e-49	0.86	0.78	0.22	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	13.2	-14.5	1.0e-47	-0.89	0.81	0.19	FALSE
12	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	12.3	-14.4	7.6e-47	-0.81	0.03	0.96	FALSE
14	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	13.2	14.4	7.6e-47	0.86	1.00	0.00	FALSE
7	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	12.3	13.6	2.7e-42	0.69	0.98	0.02	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	13.3	12.7	3.8e-37	0.86	0.07	0.91	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	8.6	-12.7	4.3e-37	-0.87	0.04	0.93	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	13.3	-11.9	1.7e-32	-0.84	0.02	0.97	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	-11.6	-11.6	3.6e-31	-0.67	0.56	0.06	FALSE
4	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	7.8	10.8	4.6e-27	0.81	0.04	0.90	FALSE
22	YFS	Blood	POMC	0.35	0.05	enet	71	0.19	5.7e-59	-10.8	-9.7	2.2e-22	-0.31	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POMC	0.19	0.01	blup	38	0.05	1.5e-04	-10.8	-8.9	3.8e-19	-0.33	0.00	0.85	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	-3.0	-8.9	6.2e-19	-0.24	0.13	0.87	FALSE
16	METSIM	Adipose	EFR3B	0.04	0.00	bslmm	357	0.00	9.7e-02	-2.7	-8.6	1.3e-17	-0.37	0.06	0.08	FALSE
20	YFS	Blood	ADCY3	0.07	0.02	bslmm	343	0.04	7.3e-14	14.6	-8.6	1.3e-17	-0.61	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	4.2	-8.4	5.1e-17	-0.55	0.35	0.60	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	POMC	0.08	0.05	lasso	3	0.06	2.6e-12	-3.0	-7.9	2.9e-15	-0.20	0.63	0.37	FALSE
5	GTEx	Adrenal Gland	PTRHD1	0.32	0.28	lasso	3	0.26	8.3e-10	-7.4	7.8	4.8e-15	0.41	0.98	0.00	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	1.7	-7.1	1.0e-12	-0.50	0.64	0.31	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	CENPO	0.08	0.04	enet	5	0.05	2.6e-07	-5.8	-7.1	1.6e-12	-0.36	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POMC	0.16	0.05	blup	39	0.11	2.4e-12	-10.8	-6.8	7.3e-12	-0.22	0.00	1.00	FALSE
6	GTEx	Artery Coronary	DNAJC27	0.12	0.03	lasso	7	0.00	2.4e-01	4.2	6.6	3.2e-11	0.46	0.14	0.22	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	NCOA1	0.02	0.01	blup	77	0.01	1.2e-02	-5.0	-6.2	4.6e-10	-0.23	0.03	0.76	FALSE