[Hub]/) : Traits : Weight :

chr12:106,649,988-113,517,494

Best TWAS P=3.62e-11 · Best GWAS P=2.37e-12 conditioned to 0.0272

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PRDM4 0.07 0.08 lasso 2 0.07 5.0e-09 6.5 6.5 8.6e-11 0.00 0.01 0.99 FALSE
2 GTEx Adipose Subcutaneous C12orf23 0.07 0.02 lasso 4 0.02 5.5e-03 -5.6 5.5 4.5e-08 0.02 0.02 0.95 FALSE
3 GTEx Adipose Subcutaneous HECTD4 0.06 0.00 enet 15 0.02 1.0e-02 3.3 -5.5 4.4e-08 0.66 0.06 0.85 FALSE
4 GTEx Adipose Subcutaneous RP11-412D9.4 0.22 0.13 lasso 5 0.13 5.1e-11 -5.4 6.0 1.7e-09 0.04 0.01 0.99 TRUE
5 GTEx Adrenal Gland PPTC7 0.13 -0.01 lasso 6 0.00 3.4e-01 5.7 5.9 3.5e-09 -0.19 0.03 0.34 FALSE
6 GTEx Artery Tibial VPS29 0.05 0.03 lasso 3 0.02 5.9e-03 5.7 5.4 5.9e-08 -0.07 0.07 0.72 FALSE
7 GTEx Artery Tibial HECTD4 0.05 0.02 lasso 3 0.01 3.1e-02 -6.5 -6.6 4.4e-11 0.85 0.01 0.92 TRUE
8 GTEx Artery Tibial RP11-412D9.4 0.06 0.05 lasso 3 0.06 2.9e-05 -5.6 5.8 4.9e-09 0.03 0.01 0.98 FALSE
9 GTEx Brain Cerebellar Hemisphere MMAB 0.31 0.27 lasso 3 0.24 6.6e-07 5.5 -5.5 3.0e-08 -0.06 0.01 0.99 FALSE
10 GTEx Brain Nucleus accumbens basal ganglia MMAB 0.40 0.24 enet 16 0.28 2.5e-08 5.4 -5.2 2.3e-07 -0.01 0.02 0.95 FALSE
11 GTEx Breast Mammary Tissue RP11-412D9.4 0.23 0.26 lasso 4 0.26 9.7e-14 -5.6 5.6 2.8e-08 0.04 0.01 0.99 FALSE
12 GTEx Breast Mammary Tissue (Female) VPS29 0.10 -0.01 lasso 2 0.02 1.0e-01 -3.7 5.1 3.1e-07 -0.24 0.03 0.12 FALSE
13 GTEx Breast Mammary Tissue (Female) ALKBH2 0.22 0.09 lasso 3 0.12 2.8e-04 5.4 5.4 5.2e-08 -0.04 0.03 0.56 FALSE
14 GTEx Breast Mammary Tissue (Female) RP11-412D9.4 0.20 0.14 lasso 4 0.13 9.0e-05 -5.6 5.1 2.7e-07 0.04 0.01 0.95 FALSE
15 GTEx Cells EBV-transformed lymphocytes KCTD10 0.36 0.18 lasso 7 0.19 1.0e-06 5.4 -5.4 7.7e-08 0.01 0.01 0.98 FALSE
16 GTEx Cells EBV-transformed lymphocytes ARPC3 0.13 0.09 lasso 4 0.04 2.0e-02 5.9 -5.9 3.5e-09 0.00 0.02 0.87 FALSE
17 GTEx Cells Transformed fibroblasts VPS29 0.09 0.13 lasso 3 0.13 9.8e-10 5.7 5.3 1.4e-07 -0.03 0.08 0.92 FALSE
18 GTEx Cells Transformed fibroblasts RP11-412D9.4 0.12 0.10 lasso 4 0.09 2.1e-07 -5.4 5.6 2.0e-08 0.03 0.02 0.98 FALSE
19 GTEx Colon Sigmoid KCTD10 0.25 0.16 lasso 8 0.15 6.2e-06 4.6 -5.2 1.9e-07 -0.03 0.12 0.85 FALSE
20 GTEx Colon Sigmoid RP11-412D9.4 0.17 0.06 lasso 3 0.07 1.4e-03 5.3 5.4 7.8e-08 -0.01 0.03 0.84 FALSE
21 GTEx Esophagus Muscularis KCTD10 0.21 0.19 lasso 6 0.17 1.3e-10 5.4 -5.5 4.9e-08 0.00 0.02 0.98 FALSE
22 GTEx Lung C12orf23 0.04 0.03 lasso 2 0.02 9.9e-03 -4.9 5.1 3.0e-07 0.03 0.05 0.82 FALSE
23 GTEx Muscle Skeletal ARPC3 0.14 0.11 enet 23 0.10 2.2e-10 5.7 -5.4 7.0e-08 -0.04 0.02 0.98 FALSE
24 GTEx Muscle Skeletal VPS29 0.06 0.06 lasso 3 0.05 4.3e-06 5.7 5.4 5.8e-08 -0.04 0.09 0.91 FALSE
25 GTEx Muscle Skeletal IFT81 0.08 0.08 lasso 5 0.07 1.7e-07 5.9 6.1 9.0e-10 0.01 0.01 0.98 TRUE
26 GTEx Muscle Skeletal ANAPC7 0.08 0.01 lasso 3 0.00 1.1e-01 4.3 5.4 7.2e-08 -0.01 0.03 0.75 FALSE
27 GTEx Nerve Tibial C12orf23 0.09 0.12 enet 10 0.12 1.1e-08 -5.6 5.8 8.6e-09 0.04 0.01 0.99 FALSE
28 GTEx Nerve Tibial HECTD4 0.05 0.01 enet 6 0.01 3.6e-02 5.5 -6.0 2.2e-09 0.48 0.22 0.46 FALSE
29 GTEx Nerve Tibial RP11-412D9.4 0.18 0.18 enet 11 0.20 5.6e-14 -5.4 5.7 1.2e-08 0.04 0.01 0.99 FALSE
30 GTEx Pancreas RP11-412D9.4 0.09 0.06 enet 12 0.06 1.2e-03 -5.6 5.3 1.4e-07 0.03 0.02 0.93 FALSE
31 GTEx Skin Not Sun Exposed Suprapubic VPS29 0.06 0.01 lasso 3 0.01 6.9e-02 5.9 5.9 2.7e-09 -0.01 0.03 0.75 FALSE
32 GTEx Skin Sun Exposed Lower leg KCTD10 0.18 0.15 lasso 5 0.14 1.4e-11 5.4 -5.2 2.2e-07 -0.01 0.02 0.98 FALSE
33 GTEx Skin Sun Exposed Lower leg ARPC3 0.13 0.15 lasso 3 0.15 1.9e-12 5.7 -5.7 9.5e-09 0.00 0.03 0.97 FALSE
34 GTEx Skin Sun Exposed Lower leg ALDH2 0.10 0.09 enet 13 0.13 6.7e-11 3.1 -5.3 9.6e-08 0.67 0.49 0.51 FALSE
35 GTEx Skin Sun Exposed Lower leg C12orf23 0.06 0.04 lasso 3 0.03 8.0e-04 -5.6 5.8 5.5e-09 0.03 0.01 0.99 FALSE
36 GTEx Spleen VPS29 0.24 0.01 enet 14 0.04 2.9e-02 4.5 5.6 2.3e-08 0.04 0.02 0.73 FALSE
37 GTEx Testis ARPC3 0.16 0.16 lasso 3 0.14 7.5e-07 5.7 -5.7 1.0e-08 0.00 0.02 0.98 FALSE
38 GTEx Testis RP11-412D9.4 0.25 0.24 lasso 5 0.20 3.7e-09 -5.6 5.7 1.4e-08 0.04 0.01 0.99 FALSE
39 GTEx Thyroid RP11-412D9.4 0.10 0.10 enet 7 0.12 9.3e-10 5.6 5.8 5.1e-09 0.02 0.01 0.99 FALSE
40 GTEx Whole Blood PRDM4 0.10 0.08 lasso 5 0.05 1.8e-05 6.6 -6.6 3.6e-11 0.00 0.01 0.99 TRUE
41 NTR Blood GPN3 0.03 0.01 blup 236 0.02 2.7e-06 4.3 -5.8 8.1e-09 0.06 0.03 0.97 FALSE
42 NTR Blood UBE3B 0.09 0.05 lasso 8 0.08 1.0e-25 5.2 6.3 2.8e-10 0.02 0.01 0.99 TRUE
43 YFS Blood GLTP 0.05 0.01 enet 14 0.04 1.5e-13 4.6 5.5 4.6e-08 -0.04 0.02 0.98 FALSE
44 YFS Blood UBE3B 0.20 0.16 enet 47 0.20 2.2e-64 5.0 5.1 2.8e-07 0.02 0.09 0.91 FALSE
45 The Cancer Genome Atlas Bladder Urothelial Carcinoma KCTD10 0.06 0.00 lasso 3 0.00 1.4e-01 5.2 -5.4 8.2e-08 -0.05 0.00 0.70 FALSE
46 The Cancer Genome Atlas Breast Invasive Carcinoma C12orf23 0.03 0.05 enet 7 0.05 2.2e-10 5.2 5.4 6.2e-08 0.00 0.03 0.97 FALSE
47 The Cancer Genome Atlas Breast Invasive Carcinoma MTERFD3 0.02 0.01 lasso 4 0.01 1.3e-03 -5.4 5.6 1.7e-08 0.02 0.02 0.90 FALSE
48 The Cancer Genome Atlas Breast Invasive Carcinoma PRDM4 0.01 0.01 lasso 1 0.01 6.3e-03 5.5 -5.5 3.6e-08 0.00 0.02 0.84 FALSE
49 The Cancer Genome Atlas Breast Invasive Carcinoma VPS29 0.02 0.02 lasso 5 0.03 4.6e-06 4.7 5.3 9.6e-08 -0.01 0.02 0.97 FALSE
50 The Cancer Genome Atlas Colon Adenocarcinoma MTERFD3 0.08 0.06 lasso 6 0.05 7.1e-04 -5.4 5.4 8.2e-08 0.03 0.01 0.74 FALSE
51 The Cancer Genome Atlas Glioblastoma Multiforme KCTD10 0.27 0.20 lasso 1 0.18 4.5e-06 5.2 -5.2 2.4e-07 -0.06 0.00 0.99 FALSE
52 The Cancer Genome Atlas Brain Lower Grade Glioma VPS29 0.06 0.06 enet 7 0.06 2.1e-07 4.8 5.4 8.3e-08 0.00 0.10 0.89 FALSE
53 The Cancer Genome Atlas Lung Adenocarcinoma RAD9B 0.04 0.03 lasso 5 0.01 7.0e-03 5.7 5.4 5.5e-08 0.00 0.01 0.99 FALSE
54 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C12orf23 0.03 0.01 blup 50 0.01 2.2e-02 -5.6 5.3 1.3e-07 0.02 0.01 0.81 FALSE
55 The Cancer Genome Atlas Pancreatic Adenocarcinoma C12orf23 0.06 0.05 enet 8 0.05 5.0e-03 -5.6 5.4 7.7e-08 0.03 0.01 0.68 FALSE
56 The Cancer Genome Atlas Prostate Adenocarcinoma ASCL4 0.03 0.03 blup 49 0.03 2.9e-04 6.5 6.0 2.2e-09 0.00 0.01 0.94 FALSE
57 The Cancer Genome Atlas Prostate Adenocarcinoma CUX2 0.08 0.01 blup 95 0.02 1.3e-03 3.3 5.2 2.2e-07 -0.16 0.04 0.45 TRUE
58 The Cancer Genome Atlas Prostate Adenocarcinoma MMAB 0.06 0.06 blup 57 0.06 5.4e-07 -4.8 -5.8 7.0e-09 -0.03 0.12 0.87 FALSE
59 The Cancer Genome Atlas Prostate Adenocarcinoma UBE3B 0.20 0.02 lasso 2 0.02 9.1e-03 -4.3 -5.3 9.7e-08 0.00 0.02 0.70 FALSE
60 The Cancer Genome Atlas Thyroid Carcinoma RAD9B 0.10 0.06 enet 5 0.06 1.2e-06 5.7 5.7 9.1e-09 0.00 0.01 0.99 FALSE