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chr12:106,649,988-113,517,494

Best TWAS P=3.62e-11 · Best GWAS P=2.37e-12 conditioned to 0.0272

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PRDM4	0.07	0.08	lasso	2	0.07	5.0e-09	6.5	6.5	8.6e-11	0.00	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	C12orf23	0.07	0.02	lasso	4	0.02	5.5e-03	-5.6	5.5	4.5e-08	0.02	0.02	0.95	FALSE
3	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	3.3	-5.5	4.4e-08	0.66	0.06	0.85	FALSE
4	GTEx	Adipose Subcutaneous	RP11-412D9.4	0.22	0.13	lasso	5	0.13	5.1e-11	-5.4	6.0	1.7e-09	0.04	0.01	0.99	TRUE
5	GTEx	Adrenal Gland	PPTC7	0.13	-0.01	lasso	6	0.00	3.4e-01	5.7	5.9	3.5e-09	-0.19	0.03	0.34	FALSE
6	GTEx	Artery Tibial	VPS29	0.05	0.03	lasso	3	0.02	5.9e-03	5.7	5.4	5.9e-08	-0.07	0.07	0.72	FALSE
7	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	-6.5	-6.6	4.4e-11	0.85	0.01	0.92	TRUE
8	GTEx	Artery Tibial	RP11-412D9.4	0.06	0.05	lasso	3	0.06	2.9e-05	-5.6	5.8	4.9e-09	0.03	0.01	0.98	FALSE
9	GTEx	Brain Cerebellar Hemisphere	MMAB	0.31	0.27	lasso	3	0.24	6.6e-07	5.5	-5.5	3.0e-08	-0.06	0.01	0.99	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	MMAB	0.40	0.24	enet	16	0.28	2.5e-08	5.4	-5.2	2.3e-07	-0.01	0.02	0.95	FALSE
11	GTEx	Breast Mammary Tissue	RP11-412D9.4	0.23	0.26	lasso	4	0.26	9.7e-14	-5.6	5.6	2.8e-08	0.04	0.01	0.99	FALSE
12	GTEx	Breast Mammary Tissue (Female)	VPS29	0.10	-0.01	lasso	2	0.02	1.0e-01	-3.7	5.1	3.1e-07	-0.24	0.03	0.12	FALSE
13	GTEx	Breast Mammary Tissue (Female)	ALKBH2	0.22	0.09	lasso	3	0.12	2.8e-04	5.4	5.4	5.2e-08	-0.04	0.03	0.56	FALSE
14	GTEx	Breast Mammary Tissue (Female)	RP11-412D9.4	0.20	0.14	lasso	4	0.13	9.0e-05	-5.6	5.1	2.7e-07	0.04	0.01	0.95	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	KCTD10	0.36	0.18	lasso	7	0.19	1.0e-06	5.4	-5.4	7.7e-08	0.01	0.01	0.98	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	ARPC3	0.13	0.09	lasso	4	0.04	2.0e-02	5.9	-5.9	3.5e-09	0.00	0.02	0.87	FALSE
17	GTEx	Cells Transformed fibroblasts	VPS29	0.09	0.13	lasso	3	0.13	9.8e-10	5.7	5.3	1.4e-07	-0.03	0.08	0.92	FALSE
18	GTEx	Cells Transformed fibroblasts	RP11-412D9.4	0.12	0.10	lasso	4	0.09	2.1e-07	-5.4	5.6	2.0e-08	0.03	0.02	0.98	FALSE
19	GTEx	Colon Sigmoid	KCTD10	0.25	0.16	lasso	8	0.15	6.2e-06	4.6	-5.2	1.9e-07	-0.03	0.12	0.85	FALSE
20	GTEx	Colon Sigmoid	RP11-412D9.4	0.17	0.06	lasso	3	0.07	1.4e-03	5.3	5.4	7.8e-08	-0.01	0.03	0.84	FALSE
21	GTEx	Esophagus Muscularis	KCTD10	0.21	0.19	lasso	6	0.17	1.3e-10	5.4	-5.5	4.9e-08	0.00	0.02	0.98	FALSE
22	GTEx	Lung	C12orf23	0.04	0.03	lasso	2	0.02	9.9e-03	-4.9	5.1	3.0e-07	0.03	0.05	0.82	FALSE
23	GTEx	Muscle Skeletal	ARPC3	0.14	0.11	enet	23	0.10	2.2e-10	5.7	-5.4	7.0e-08	-0.04	0.02	0.98	FALSE
24	GTEx	Muscle Skeletal	VPS29	0.06	0.06	lasso	3	0.05	4.3e-06	5.7	5.4	5.8e-08	-0.04	0.09	0.91	FALSE
25	GTEx	Muscle Skeletal	IFT81	0.08	0.08	lasso	5	0.07	1.7e-07	5.9	6.1	9.0e-10	0.01	0.01	0.98	TRUE
26	GTEx	Muscle Skeletal	ANAPC7	0.08	0.01	lasso	3	0.00	1.1e-01	4.3	5.4	7.2e-08	-0.01	0.03	0.75	FALSE
27	GTEx	Nerve Tibial	C12orf23	0.09	0.12	enet	10	0.12	1.1e-08	-5.6	5.8	8.6e-09	0.04	0.01	0.99	FALSE
28	GTEx	Nerve Tibial	HECTD4	0.05	0.01	enet	6	0.01	3.6e-02	5.5	-6.0	2.2e-09	0.48	0.22	0.46	FALSE
29	GTEx	Nerve Tibial	RP11-412D9.4	0.18	0.18	enet	11	0.20	5.6e-14	-5.4	5.7	1.2e-08	0.04	0.01	0.99	FALSE
30	GTEx	Pancreas	RP11-412D9.4	0.09	0.06	enet	12	0.06	1.2e-03	-5.6	5.3	1.4e-07	0.03	0.02	0.93	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	VPS29	0.06	0.01	lasso	3	0.01	6.9e-02	5.9	5.9	2.7e-09	-0.01	0.03	0.75	FALSE
32	GTEx	Skin Sun Exposed Lower leg	KCTD10	0.18	0.15	lasso	5	0.14	1.4e-11	5.4	-5.2	2.2e-07	-0.01	0.02	0.98	FALSE
33	GTEx	Skin Sun Exposed Lower leg	ARPC3	0.13	0.15	lasso	3	0.15	1.9e-12	5.7	-5.7	9.5e-09	0.00	0.03	0.97	FALSE
34	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	3.1	-5.3	9.6e-08	0.67	0.49	0.51	FALSE
35	GTEx	Skin Sun Exposed Lower leg	C12orf23	0.06	0.04	lasso	3	0.03	8.0e-04	-5.6	5.8	5.5e-09	0.03	0.01	0.99	FALSE
36	GTEx	Spleen	VPS29	0.24	0.01	enet	14	0.04	2.9e-02	4.5	5.6	2.3e-08	0.04	0.02	0.73	FALSE
37	GTEx	Testis	ARPC3	0.16	0.16	lasso	3	0.14	7.5e-07	5.7	-5.7	1.0e-08	0.00	0.02	0.98	FALSE
38	GTEx	Testis	RP11-412D9.4	0.25	0.24	lasso	5	0.20	3.7e-09	-5.6	5.7	1.4e-08	0.04	0.01	0.99	FALSE
39	GTEx	Thyroid	RP11-412D9.4	0.10	0.10	enet	7	0.12	9.3e-10	5.6	5.8	5.1e-09	0.02	0.01	0.99	FALSE
40	GTEx	Whole Blood	PRDM4	0.10	0.08	lasso	5	0.05	1.8e-05	6.6	-6.6	3.6e-11	0.00	0.01	0.99	TRUE
41	NTR	Blood	GPN3	0.03	0.01	blup	236	0.02	2.7e-06	4.3	-5.8	8.1e-09	0.06	0.03	0.97	FALSE
42	NTR	Blood	UBE3B	0.09	0.05	lasso	8	0.08	1.0e-25	5.2	6.3	2.8e-10	0.02	0.01	0.99	TRUE
43	YFS	Blood	GLTP	0.05	0.01	enet	14	0.04	1.5e-13	4.6	5.5	4.6e-08	-0.04	0.02	0.98	FALSE
44	YFS	Blood	UBE3B	0.20	0.16	enet	47	0.20	2.2e-64	5.0	5.1	2.8e-07	0.02	0.09	0.91	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KCTD10	0.06	0.00	lasso	3	0.00	1.4e-01	5.2	-5.4	8.2e-08	-0.05	0.00	0.70	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf23	0.03	0.05	enet	7	0.05	2.2e-10	5.2	5.4	6.2e-08	0.00	0.03	0.97	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	MTERFD3	0.02	0.01	lasso	4	0.01	1.3e-03	-5.4	5.6	1.7e-08	0.02	0.02	0.90	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	PRDM4	0.01	0.01	lasso	1	0.01	6.3e-03	5.5	-5.5	3.6e-08	0.00	0.02	0.84	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS29	0.02	0.02	lasso	5	0.03	4.6e-06	4.7	5.3	9.6e-08	-0.01	0.02	0.97	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	MTERFD3	0.08	0.06	lasso	6	0.05	7.1e-04	-5.4	5.4	8.2e-08	0.03	0.01	0.74	FALSE
51	The Cancer Genome Atlas	Glioblastoma Multiforme	KCTD10	0.27	0.20	lasso	1	0.18	4.5e-06	5.2	-5.2	2.4e-07	-0.06	0.00	0.99	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS29	0.06	0.06	enet	7	0.06	2.1e-07	4.8	5.4	8.3e-08	0.00	0.10	0.89	FALSE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	RAD9B	0.04	0.03	lasso	5	0.01	7.0e-03	5.7	5.4	5.5e-08	0.00	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C12orf23	0.03	0.01	blup	50	0.01	2.2e-02	-5.6	5.3	1.3e-07	0.02	0.01	0.81	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C12orf23	0.06	0.05	enet	8	0.05	5.0e-03	-5.6	5.4	7.7e-08	0.03	0.01	0.68	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	ASCL4	0.03	0.03	blup	49	0.03	2.9e-04	6.5	6.0	2.2e-09	0.00	0.01	0.94	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	CUX2	0.08	0.01	blup	95	0.02	1.3e-03	3.3	5.2	2.2e-07	-0.16	0.04	0.45	TRUE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMAB	0.06	0.06	blup	57	0.06	5.4e-07	-4.8	-5.8	7.0e-09	-0.03	0.12	0.87	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBE3B	0.20	0.02	lasso	2	0.02	9.1e-03	-4.3	-5.3	9.7e-08	0.00	0.02	0.70	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	RAD9B	0.10	0.06	enet	5	0.06	1.2e-06	5.7	5.7	9.1e-09	0.00	0.01	0.99	FALSE