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chr12:121,194,565-125,155,900

Best TWAS P=6.14e-22 · Best GWAS P=2.77e-27 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
46	The Cancer Genome Atlas	Stomach Adenocarcinoma	MLXIP	0.06	0.02	blup	68	0.04	1.2e-03	9.1	9.6	6.1e-22	-0.23	0.02	0.88	TRUE
4	GTEx	Adipose Subcutaneous	ZCCHC8	0.04	0.00	lasso	7	0.00	1.4e-01	6.4	8.9	6.9e-19	-0.31	0.16	0.12	TRUE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	MLXIP	0.06	0.04	lasso	7	0.02	2.7e-02	9.0	8.8	1.3e-18	-0.17	0.02	0.94	TRUE
17	GTEx	Colon Transverse	MLXIP	0.20	0.18	enet	23	0.14	5.8e-07	9.2	8.8	1.9e-18	-0.17	1.00	0.00	TRUE
45	The Cancer Genome Atlas	Rectum Adenocarcinoma	MLXIP	0.18	0.14	lasso	4	0.13	5.1e-04	8.3	8.7	2.3e-18	-0.16	0.02	0.89	TRUE
48	The Cancer Genome Atlas	Thyroid Carcinoma	VPS33A	0.06	0.00	enet	8	0.03	9.6e-04	6.3	-7.9	3.1e-15	0.20	0.06	0.94	TRUE
30	METSIM	Adipose	ABCB9	0.04	0.03	enet	19	0.03	7.7e-05	-5.7	-7.8	5.8e-15	0.38	0.08	0.65	TRUE
16	GTEx	Cells Transformed fibroblasts	BCL7A	0.06	0.01	lasso	4	0.01	3.1e-02	2.9	-7.0	3.1e-12	0.24	0.09	0.05	TRUE
27	GTEx	Skin Sun Exposed Lower leg	WDR66	0.19	0.10	lasso	5	0.08	5.5e-07	5.0	6.9	6.1e-12	-0.11	0.99	0.00	TRUE
8	GTEx	Adipose Visceral Omentum	CCDC92	0.19	0.02	lasso	8	0.09	3.3e-05	3.1	6.6	3.3e-11	-0.12	0.61	0.21	TRUE
19	GTEx	Esophagus Mucosa	KDM2B	0.11	0.04	enet	22	0.10	4.1e-07	1.8	6.2	5.6e-10	-0.10	0.92	0.01	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CCDC62	0.12	0.06	enet	21	0.06	3.3e-08	3.6	-6.1	7.8e-10	0.13	0.99	0.00	TRUE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPR81	0.07	0.02	blup	54	0.02	4.4e-03	6.1	5.8	6.0e-09	-0.13	0.04	0.20	TRUE
28	GTEx	Testis	ABCB9	0.14	0.05	lasso	3	0.06	8.0e-04	8.2	-8.7	2.5e-18	0.22	0.25	0.06	FALSE
24	GTEx	Muscle Skeletal	RSRC2	0.06	0.03	enet	7	0.04	9.6e-05	-4.8	-8.6	7.2e-18	0.43	0.20	0.57	FALSE
25	GTEx	Nerve Tibial	KNTC1	0.12	0.05	lasso	5	0.05	1.9e-04	-6.8	-7.6	2.9e-14	0.31	0.51	0.07	FALSE
20	GTEx	Esophagus Mucosa	HIP1R	0.21	0.05	lasso	5	0.07	1.5e-05	3.9	7.5	4.5e-14	-0.21	0.48	0.25	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRRC43	0.04	0.00	blup	58	0.01	6.9e-02	8.2	-7.5	9.0e-14	0.12	0.02	0.19	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS33A	0.01	0.02	lasso	2	0.02	2.7e-04	6.9	-7.0	2.1e-12	0.14	0.30	0.32	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	VPS33A	0.04	0.05	lasso	1	0.04	3.0e-05	6.9	-6.9	4.1e-12	0.13	0.84	0.15	FALSE
15	GTEx	Breast Mammary Tissue (Female)	C12orf65	0.06	0.00	enet	13	-0.01	6.5e-01	-4.1	-6.9	5.2e-12	0.27	0.05	0.07	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC43	0.03	0.03	enet	8	0.02	1.5e-03	-4.9	-6.8	7.6e-12	0.15	0.10	0.06	FALSE
31	METSIM	Adipose	CLIP1	0.03	0.01	bslmm	372	0.01	3.3e-03	-6.4	6.8	1.4e-11	-0.31	0.58	0.06	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS33A	0.03	0.05	lasso	1	0.05	4.4e-06	6.7	-6.7	2.4e-11	0.13	0.92	0.04	FALSE
18	GTEx	Colon Transverse	SNRNP35	0.18	0.02	lasso	8	0.04	6.5e-03	-4.4	6.5	6.3e-11	-0.16	0.04	0.44	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LRRC43	0.06	0.03	enet	6	0.03	8.7e-04	-5.1	-6.5	7.4e-11	0.10	0.13	0.22	FALSE
34	YFS	Blood	PSMD9	0.04	0.03	bslmm	324	0.05	8.2e-15	-5.7	6.5	1.0e-10	-0.08	1.00	0.00	FALSE
33	METSIM	Adipose	WDR66	0.04	0.00	blup	341	0.01	1.4e-02	5.2	6.2	7.7e-10	-0.17	0.05	0.03	FALSE
13	GTEx	Brain Hippocampus	CLIP1	0.27	0.14	lasso	4	0.12	1.0e-03	-4.0	-6.0	1.4e-09	0.24	0.05	0.47	FALSE
10	GTEx	Adipose Visceral Omentum	RP11-380L11.3	0.15	0.03	lasso	5	0.01	1.4e-01	4.8	5.9	3.0e-09	-0.08	0.14	0.16	FALSE
11	GTEx	Artery Aorta	C12orf65	0.11	0.07	lasso	10	0.08	5.8e-05	4.3	-5.9	3.0e-09	0.21	0.77	0.02	FALSE
29	GTEx	Thyroid	WDR66	0.11	0.02	lasso	6	0.02	1.1e-02	-4.4	5.8	7.4e-09	-0.01	0.14	0.05	FALSE
32	METSIM	Adipose	MLXIP	0.08	0.07	enet	25	0.07	2.3e-10	-6.2	5.7	9.2e-09	-0.07	1.00	0.00	FALSE
9	GTEx	Adipose Visceral Omentum	RP11-282O18.3	0.14	0.11	enet	12	0.10	6.7e-06	4.8	-5.7	9.3e-09	0.12	0.98	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	MPHOSPH9	0.07	0.02	lasso	4	0.00	3.5e-01	4.8	5.7	1.1e-08	-0.13	0.14	0.08	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	KNTC1	0.11	0.04	lasso	4	0.03	7.1e-03	5.9	-5.7	1.1e-08	0.14	0.22	0.04	FALSE
7	GTEx	Adipose Visceral Omentum	CDK2AP1	0.14	0.14	lasso	4	0.11	2.7e-06	4.8	-5.7	1.5e-08	0.12	0.99	0.00	FALSE
22	GTEx	Lung	CDK2AP1	0.08	0.03	lasso	4	0.00	2.0e-01	4.5	-5.6	2.2e-08	0.12	0.58	0.05	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TMEM120B	0.11	0.04	lasso	3	0.08	1.9e-09	4.2	5.6	2.6e-08	-0.03	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	PSMD9	0.09	0.10	lasso	4	0.10	7.4e-10	-5.7	5.5	2.9e-08	-0.02	0.01	0.99	FALSE
14	GTEx	Brain Putamen basal ganglia	WDR66	0.25	0.01	enet	16	-0.01	5.6e-01	8.2	-5.5	3.1e-08	0.15	0.06	0.25	FALSE
12	GTEx	Brain Cerebellum	TMEM120B	0.28	0.06	enet	18	0.04	2.6e-02	6.2	-5.5	3.2e-08	0.03	0.07	0.11	FALSE
5	GTEx	Adipose Subcutaneous	CCDC92	0.23	0.04	enet	27	0.16	6.9e-13	-3.9	5.5	4.2e-08	-0.09	0.56	0.43	FALSE
23	GTEx	Lung	CCDC92	0.14	0.00	enet	10	0.01	1.1e-01	5.2	5.4	7.4e-08	-0.08	0.18	0.15	FALSE
21	GTEx	Esophagus Muscularis	CDK2AP1	0.17	0.10	enet	18	0.11	4.6e-07	4.4	-5.3	1.4e-07	0.12	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HIP1R	0.06	0.02	lasso	6	0.04	1.9e-05	-5.7	-5.2	1.7e-07	0.09	0.18	0.02	FALSE
38	The Cancer Genome Atlas	Esophageal Carcinoma	LOC338799	0.10	0.02	blup	30	0.06	6.9e-03	5.8	-5.2	1.8e-07	-0.01	0.00	0.77	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPR109A	0.03	0.01	blup	21	0.01	1.3e-02	-4.0	-5.2	1.8e-07	0.29	0.05	0.03	FALSE