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chr17:44,788,310-47,688,526

Best TWAS P=4.14e-12 · Best GWAS P=3.27e-14 conditioned to 6.66e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
30	YFS	Blood	UBE2Z	0.06	0.03	enet	19	0.06	1.5e-18	3.62	6.9	4.1e-12	0.10	0.48	0.52	TRUE
20	GTEx	Heart Atrial Appendage	CDK5RAP3	0.13	0.00	enet	18	0.04	5.1e-03	2.52	-6.8	1.4e-11	-0.42	0.09	0.05	TRUE
22	GTEx	Muscle Skeletal	AC003665.1	0.05	0.03	enet	8	0.03	1.4e-03	5.43	6.7	1.9e-11	0.63	0.12	0.73	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	CBX1	0.03	0.04	lasso	4	0.04	3.7e-05	6.81	-6.7	2.0e-11	-0.84	0.01	0.99	FALSE
26	GTEx	Testis	RP11-6N17.4	0.14	0.02	lasso	10	0.02	4.8e-02	6.74	6.6	4.1e-11	0.78	0.14	0.73	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	RP11-6N17.9	0.47	0.05	lasso	17	0.11	8.3e-04	5.98	-6.5	6.7e-11	-0.65	0.10	0.45	FALSE
12	GTEx	Brain Cerebellar Hemisphere	CDK5RAP3	0.22	0.10	lasso	6	0.09	2.6e-03	5.23	-6.5	9.4e-11	-0.74	0.08	0.43	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	CDK5RAP3	0.21	0.04	lasso	4	0.02	7.2e-02	6.80	-6.5	1.0e-10	-0.78	0.07	0.42	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	CALCOCO2	0.04	0.03	blup	50	0.02	1.6e-03	-4.86	6.3	3.1e-10	0.08	0.01	0.56	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CDK5RAP3	0.15	0.12	bslmm	392	0.14	3.6e-16	6.45	-6.3	3.7e-10	-0.78	0.42	0.58	FALSE
25	GTEx	Stomach	RP11-6N17.9	0.13	0.02	lasso	6	0.04	8.0e-03	5.83	-6.2	4.3e-10	-0.70	0.11	0.70	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CBX1	0.03	0.01	lasso	3	0.01	8.7e-03	6.80	-6.2	4.5e-10	-0.80	0.01	0.80	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TTLL6	0.23	0.12	bslmm	418	0.15	1.7e-17	2.68	-6.2	5.6e-10	-0.19	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDK5RAP3	0.06	0.00	blup	62	0.03	1.0e-03	-3.30	-6.1	9.0e-10	-0.35	0.01	0.83	FALSE
9	GTEx	Artery Aorta	RP11-6N17.10	0.20	0.07	enet	24	0.14	3.5e-08	-4.20	-6.0	1.7e-09	-0.43	0.45	0.19	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	CDK5RAP3	0.21	0.09	lasso	6	0.07	1.2e-03	-4.20	-6.0	2.0e-09	-0.30	0.09	0.50	FALSE
10	GTEx	Brain Caudate basal ganglia	RP11-6N17.9	0.45	-0.01	enet	28	0.16	3.3e-05	-0.84	-6.0	2.7e-09	-0.48	0.06	0.16	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDK5RAP3	0.05	0.03	lasso	2	0.02	1.8e-05	5.83	-5.9	3.3e-09	-0.76	0.00	1.00	FALSE
13	GTEx	Brain Cerebellar Hemisphere	RP11-6N17.10	0.21	0.16	lasso	5	0.13	3.8e-04	5.23	-5.9	3.9e-09	-0.73	0.08	0.46	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	RP11-6N17.9	0.18	0.14	lasso	3	0.09	4.9e-04	-4.20	-5.8	5.5e-09	-0.49	0.03	0.72	FALSE
23	GTEx	Pancreas	CDK5RAP3	0.11	-0.01	lasso	4	0.02	5.1e-02	5.23	-5.8	6.0e-09	-0.48	0.09	0.18	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNX11	0.07	0.07	blup	53	0.08	1.4e-09	3.99	-5.7	1.4e-08	-0.58	0.95	0.05	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-6N17.9	0.13	0.04	enet	16	0.05	8.4e-04	-2.84	-5.7	1.5e-08	-0.47	0.25	0.34	FALSE
27	GTEx	Thyroid	CDK5RAP3	0.21	0.14	lasso	5	0.18	1.6e-13	-4.20	-5.7	1.5e-08	-0.51	1.00	0.00	FALSE
29	GTEx	Thyroid	RP11-6N17.10	0.19	0.12	lasso	5	0.13	3.0e-10	-4.20	-5.6	2.5e-08	-0.47	1.00	0.00	FALSE
11	GTEx	Brain Cerebellar Hemisphere	SNX11	0.25	0.19	enet	38	0.22	2.0e-06	3.80	-5.5	3.2e-08	-0.52	0.22	0.09	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	ATP5G1	0.19	0.03	lasso	3	0.08	4.4e-08	5.64	5.5	4.7e-08	0.08	0.00	1.00	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	KPNB1	0.24	0.00	lasso	9	0.01	2.1e-01	0.85	-5.5	4.8e-08	-0.80	0.02	0.79	FALSE
28	GTEx	Thyroid	RP11-6N17.9	0.22	0.14	lasso	5	0.14	5.2e-11	-4.20	-5.5	4.8e-08	-0.44	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Rectum Adenocarcinoma	SNX11	0.12	0.10	enet	22	0.12	9.4e-04	3.94	-5.4	6.2e-08	-0.70	0.03	0.68	FALSE
4	GTEx	Adipose Subcutaneous	RP11-6N17.9	0.10	0.05	enet	14	0.05	6.8e-05	-3.63	-5.4	6.5e-08	-0.42	0.46	0.07	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	CALCOCO2	0.08	0.03	blup	50	0.07	1.4e-07	-4.59	5.3	9.3e-08	0.05	0.02	0.96	FALSE
8	GTEx	Artery Aorta	RP11-6N17.9	0.23	0.12	enet	19	0.19	9.5e-11	-4.20	-5.3	9.7e-08	-0.42	0.99	0.01	FALSE
21	GTEx	Liver	SCRN2	0.32	0.05	enet	14	0.11	5.5e-04	-3.60	5.3	1.1e-07	0.43	0.09	0.57	FALSE
39	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SNX11	0.23	0.07	enet	16	0.14	1.3e-04	3.92	-5.3	1.3e-07	-0.57	0.16	0.54	FALSE
24	GTEx	Pancreas	RP11-6N17.9	0.15	0.04	lasso	5	0.04	9.3e-03	-1.44	-5.3	1.4e-07	-0.47	0.13	0.17	FALSE
17	GTEx	Cells Transformed fibroblasts	RP11-6N17.9	0.14	0.04	enet	17	0.08	2.3e-06	-4.20	-5.2	1.7e-07	-0.39	0.96	0.02	FALSE
3	GTEx	Adipose Subcutaneous	CDK5RAP3	0.13	0.11	enet	11	0.14	1.4e-11	-3.53	-5.2	2.0e-07	-0.38	1.00	0.00	FALSE
7	GTEx	Artery Aorta	CDK5RAP3	0.26	0.22	lasso	11	0.25	5.8e-14	-4.20	-5.1	2.7e-07	-0.35	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	MRPL45P2	0.24	0.00	enet	24	0.01	1.2e-01	5.23	-5.1	2.9e-07	-0.40	0.03	0.41	FALSE