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chr6:108,183,628-110,844,259

Best TWAS P=7.08e-19 · Best GWAS P=7.75e-28 conditioned to 1.1e-11

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
66	YFS	Blood	FOXO3	0.03	0.01	lasso	3	0.02	3.2e-07	-9.9	8.9	7.1e-19	-0.78	0.39	0.61	TRUE
20	GTEx	Brain Cortex	AK9	0.21	0.03	enet	29	0.16	3.2e-05	-6.0	7.2	4.1e-13	0.03	0.09	0.85	TRUE
95	The Cancer Genome Atlas	Thyroid Carcinoma	CD164	0.03	0.01	blup	49	0.01	2.1e-02	-6.2	-7.2	7.2e-13	-0.02	0.02	0.81	FALSE
71	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SMPD2	0.07	0.08	blup	45	0.07	2.3e-04	-6.3	-7.1	1.6e-12	0.01	0.03	0.93	FALSE
73	The Cancer Genome Atlas	Esophageal Carcinoma	SMPD2	0.12	0.09	blup	41	0.07	2.6e-03	-6.5	-7.0	2.5e-12	-0.02	0.02	0.86	FALSE
86	The Cancer Genome Atlas	Lung Adenocarcinoma	AKD1	0.05	0.03	blup	122	0.04	1.3e-05	-6.3	7.0	2.5e-12	0.01	0.02	0.98	FALSE
28	GTEx	Colon Sigmoid	FIG4	0.17	0.11	lasso	9	0.03	3.7e-02	-6.7	7.0	3.4e-12	0.02	0.03	0.90	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKD1	0.11	0.08	lasso	5	0.10	5.8e-11	-6.8	6.8	7.8e-12	0.02	0.01	0.99	FALSE
57	GTEx	Whole Blood	RP11-425D10.10	0.04	0.03	enet	16	0.03	6.2e-04	-6.1	-6.8	8.2e-12	-0.02	0.03	0.96	FALSE
4	GTEx	Adipose Subcutaneous	SMPD2	0.14	0.10	lasso	10	0.12	2.3e-10	-6.2	-6.8	1.0e-11	0.00	0.14	0.86	FALSE
9	GTEx	Artery Aorta	AK9	0.16	0.14	enet	32	0.14	3.7e-08	5.2	6.8	1.1e-11	0.02	0.26	0.74	FALSE
5	GTEx	Adipose Subcutaneous	AK9	0.12	0.09	lasso	7	0.10	2.1e-08	-6.2	6.7	1.6e-11	0.02	0.11	0.88	FALSE
55	GTEx	Vagina	RP11-425D10.10	0.42	0.22	lasso	19	0.17	9.0e-05	-6.2	-6.7	1.7e-11	-0.01	0.03	0.94	FALSE
32	GTEx	Esophagus Mucosa	SMPD2	0.17	0.20	lasso	10	0.22	2.2e-14	-6.5	-6.7	1.8e-11	-0.01	0.02	0.98	FALSE
14	GTEx	Artery Tibial	MICAL1	0.08	0.02	lasso	3	0.01	6.5e-02	-6.7	-6.7	1.9e-11	-0.01	0.02	0.97	FALSE
12	GTEx	Artery Coronary	AK9	0.27	0.26	enet	18	0.28	5.2e-10	5.2	6.7	2.7e-11	0.02	0.49	0.51	FALSE
48	GTEx	Skin Sun Exposed Lower leg	SMPD2	0.19	0.19	lasso	12	0.24	1.6e-19	-6.0	-6.6	3.1e-11	-0.01	0.22	0.78	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZBTB24	0.04	0.05	lasso	4	0.04	7.8e-06	-6.8	6.6	3.2e-11	0.01	0.01	0.99	FALSE
59	METSIM	Adipose	SMPD2	0.06	0.08	enet	14	0.08	2.0e-12	-6.3	-6.6	3.6e-11	0.01	0.11	0.89	FALSE
58	METSIM	Adipose	AK9	0.05	0.03	lasso	6	0.02	1.0e-04	-5.4	6.5	5.8e-11	0.03	0.02	0.98	FALSE
15	GTEx	Artery Tibial	AK9	0.13	0.12	enet	18	0.13	3.5e-10	-6.3	6.5	6.5e-11	0.02	0.19	0.81	FALSE
26	GTEx	Breast Mammary Tissue (Female)	RP11-425D10.10	0.14	0.04	lasso	10	0.02	6.5e-02	-6.5	-6.5	8.1e-11	-0.01	0.03	0.54	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	CD164	0.07	0.01	enet	16	0.05	1.6e-07	-6.6	6.5	8.1e-11	0.01	0.04	0.95	FALSE
33	GTEx	Esophagus Mucosa	AK9	0.11	0.06	lasso	13	0.04	6.0e-04	-6.0	6.5	1.0e-10	0.03	0.03	0.96	FALSE
40	GTEx	Lung	RP11-425D10.10	0.10	0.08	enet	24	0.07	6.4e-06	-6.6	-6.4	1.4e-10	-0.03	0.03	0.97	FALSE
43	GTEx	Nerve Tibial	AK9	0.18	0.15	enet	26	0.18	1.5e-12	-6.2	6.4	1.4e-10	0.04	0.21	0.79	FALSE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMPD2	0.04	0.07	lasso	4	0.07	8.8e-14	-6.3	-6.4	1.4e-10	0.00	0.04	0.96	FALSE
35	GTEx	Esophagus Muscularis	FIG4	0.14	0.02	enet	10	0.03	7.8e-03	-6.0	6.4	1.6e-10	0.05	0.11	0.71	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	RP11-425D10.10	0.20	0.27	lasso	5	0.27	5.5e-15	-6.3	-6.4	1.8e-10	-0.01	0.17	0.83	FALSE
67	YFS	Blood	SMPD2	0.06	0.08	lasso	7	0.08	2.5e-24	-6.2	-6.4	1.8e-10	0.00	0.06	0.94	FALSE
39	GTEx	Lung	SMPD2	0.10	0.12	lasso	2	0.10	7.5e-08	-6.4	-6.3	2.1e-10	0.01	0.13	0.87	FALSE
90	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SMPD2	0.08	0.07	lasso	3	0.05	3.3e-03	-6.4	-6.3	2.1e-10	0.01	0.03	0.87	FALSE
92	The Cancer Genome Atlas	Rectum Adenocarcinoma	SMPD2	0.13	0.08	lasso	2	0.06	1.5e-02	-6.4	-6.4	2.1e-10	0.01	0.01	0.40	FALSE
44	GTEx	Ovary	RP11-425D10.10	0.15	0.10	lasso	5	0.02	9.0e-02	-6.2	-6.3	2.2e-10	-0.02	0.04	0.85	FALSE
80	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SMPD2	0.12	0.15	enet	6	0.14	3.8e-08	-6.3	-6.3	2.2e-10	0.01	0.06	0.94	FALSE
91	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMPD2	0.08	0.13	lasso	3	0.13	2.4e-13	-6.3	-6.3	2.2e-10	0.01	0.10	0.90	FALSE
29	GTEx	Colon Transverse	SMPD2	0.19	0.25	lasso	5	0.24	1.1e-11	-6.4	-6.3	2.4e-10	0.01	0.08	0.92	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKD1	0.12	0.11	lasso	6	0.12	9.8e-14	-6.0	6.3	2.5e-10	0.02	0.23	0.77	FALSE
68	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AKD1	0.08	0.06	blup	114	0.05	4.7e-05	-6.0	6.3	2.8e-10	0.01	0.06	0.94	FALSE
50	GTEx	Skin Sun Exposed Lower leg	RP11-425D10.10	0.19	0.23	enet	18	0.23	3.4e-19	-6.3	-6.3	2.9e-10	-0.01	0.21	0.79	FALSE
30	GTEx	Colon Transverse	RP11-425D10.10	0.12	0.13	enet	21	0.14	2.2e-07	-6.7	-6.3	3.0e-10	-0.02	0.03	0.97	FALSE
88	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SMPD2	0.04	0.06	blup	45	0.06	8.9e-08	-6.6	-6.3	3.0e-10	-0.01	0.03	0.97	FALSE
18	GTEx	Brain Cerebellar Hemisphere	AK9	0.24	0.17	lasso	3	0.11	1.0e-03	-6.2	6.3	3.6e-10	0.00	0.14	0.60	FALSE
34	GTEx	Esophagus Mucosa	RP11-425D10.10	0.09	0.13	lasso	5	0.12	1.1e-08	-6.2	-6.3	3.8e-10	-0.01	0.15	0.85	FALSE
23	GTEx	Breast Mammary Tissue	RP11-425D10.10	0.12	0.12	lasso	1	0.08	5.1e-05	-6.2	-6.2	4.4e-10	-0.01	0.04	0.95	FALSE
25	GTEx	Breast Mammary Tissue (Female)	AK9	0.12	0.15	lasso	1	0.12	1.9e-04	-6.2	6.2	4.4e-10	0.01	0.06	0.63	FALSE
36	GTEx	Esophagus Muscularis	CD164	0.04	0.02	enet	6	0.01	1.0e-01	-6.0	-6.2	4.5e-10	-0.02	0.06	0.79	FALSE
85	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PPIL6	0.07	0.03	blup	53	0.02	5.8e-02	-6.4	6.2	4.5e-10	0.00	0.02	0.59	FALSE
94	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SMPD2	0.23	0.13	lasso	5	0.17	1.4e-06	-6.3	-6.2	4.6e-10	-0.01	0.02	0.98	FALSE
41	GTEx	Muscle Skeletal	AK9	0.08	0.02	lasso	6	0.03	4.3e-04	5.2	6.2	4.9e-10	0.03	0.19	0.79	FALSE
53	GTEx	Testis	ZBTB24	0.11	0.11	lasso	4	0.10	4.9e-05	-6.2	6.2	5.4e-10	0.00	0.15	0.80	FALSE
13	GTEx	Artery Tibial	FIG4	0.18	0.01	enet	41	0.07	4.1e-06	-3.7	6.2	6.7e-10	-0.01	0.11	0.71	FALSE
51	GTEx	Small Intestine Terminal Ileum	RP11-425D10.10	0.16	0.07	lasso	9	0.06	1.5e-02	-6.5	-6.2	7.0e-10	-0.01	0.04	0.66	FALSE
79	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKD1	0.11	0.06	lasso	3	0.06	2.7e-04	-6.0	6.1	1.2e-09	0.01	0.05	0.95	FALSE
93	The Cancer Genome Atlas	Stomach Adenocarcinoma	SMPD2	0.07	0.07	blup	44	0.08	3.4e-06	-6.8	-6.1	1.2e-09	0.00	0.01	0.99	FALSE
54	GTEx	Testis	SMPD2	0.28	0.18	lasso	7	0.17	7.6e-08	-6.4	-6.1	1.3e-09	0.00	0.04	0.96	FALSE
17	GTEx	Brain Caudate basal ganglia	AK9	0.20	0.16	enet	16	0.17	1.1e-05	-6.0	6.1	1.4e-09	-0.01	0.10	0.85	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	SMPD2	0.27	0.15	lasso	10	0.17	1.6e-09	-6.2	-6.0	1.4e-09	-0.01	0.11	0.89	FALSE
77	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FIG4	0.07	0.02	lasso	2	0.04	5.5e-05	5.2	6.0	1.5e-09	0.04	0.12	0.50	FALSE
21	GTEx	Breast Mammary Tissue	SMPD2	0.14	0.09	lasso	5	0.05	2.2e-03	-6.4	-6.0	2.2e-09	0.01	0.09	0.82	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMPD2	0.05	0.07	lasso	4	0.06	9.6e-08	-5.1	-6.0	2.4e-09	0.01	0.04	0.96	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	ZBTB24	0.03	0.00	blup	389	0.00	7.3e-02	-5.4	6.0	2.7e-09	0.02	0.05	0.85	FALSE
24	GTEx	Breast Mammary Tissue (Male)	AK9	0.10	0.03	lasso	3	-0.01	5.4e-01	-5.4	5.9	2.9e-09	0.03	0.03	0.49	FALSE
16	GTEx	Artery Tibial	RP11-425D10.10	0.10	0.10	lasso	4	0.10	3.9e-08	-6.8	-5.9	3.0e-09	-0.01	0.02	0.98	FALSE
38	GTEx	Heart Atrial Appendage	RP11-425D10.10	0.12	0.11	lasso	5	0.07	4.0e-04	-6.2	-5.9	3.5e-09	-0.03	0.08	0.90	FALSE
49	GTEx	Skin Sun Exposed Lower leg	AK9	0.14	0.12	lasso	3	0.14	1.9e-11	-6.2	5.9	4.4e-09	0.03	0.22	0.78	FALSE
45	GTEx	Pancreas	SMPD2	0.09	0.07	lasso	3	0.08	2.1e-04	-6.4	-5.8	4.8e-09	0.01	0.06	0.85	FALSE
89	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SMPD2	0.06	0.05	lasso	3	0.06	9.2e-05	-6.4	-5.8	4.8e-09	0.04	0.06	0.91	FALSE
52	GTEx	Stomach	RP11-425D10.10	0.25	0.10	lasso	6	0.09	3.0e-05	-6.6	-5.8	4.9e-09	-0.01	0.02	0.97	FALSE
27	GTEx	Cells Transformed fibroblasts	SMPD2	0.20	0.13	lasso	9	0.15	3.1e-11	-6.4	-5.8	7.3e-09	0.00	0.20	0.80	FALSE
75	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMPD2	0.09	0.09	blup	42	0.10	2.1e-11	-6.6	-5.8	8.7e-09	0.01	0.03	0.97	FALSE
56	GTEx	Whole Blood	SMPD2	0.15	0.16	lasso	8	0.15	1.0e-13	-6.4	-5.8	9.1e-09	0.00	0.14	0.86	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	FIG4	0.14	0.13	lasso	6	0.14	3.8e-17	-4.3	5.7	1.1e-08	0.05	0.84	0.16	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	SMPD2	0.15	0.17	enet	14	0.18	9.4e-18	-6.3	-5.7	1.1e-08	0.01	0.07	0.93	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	SMPD2	0.12	0.10	lasso	5	0.09	1.3e-11	-6.2	-5.7	1.2e-08	0.01	0.13	0.87	FALSE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	MICAL1	0.08	0.11	lasso	4	0.12	1.8e-13	-5.1	5.7	1.2e-08	-0.03	0.12	0.88	FALSE
74	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AKD1	0.07	0.06	blup	116	0.06	4.2e-07	-6.7	5.7	1.3e-08	0.01	0.02	0.98	FALSE
7	GTEx	Adipose Visceral Omentum	RP11-425D10.10	0.16	0.10	lasso	6	0.06	7.2e-04	-6.2	-5.7	1.4e-08	-0.02	0.10	0.85	FALSE
8	GTEx	Artery Aorta	SMPD2	0.10	0.04	enet	11	0.03	1.5e-02	-5.4	-5.7	1.5e-08	-0.05	0.04	0.94	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	AK9	0.08	0.06	bslmm	456	0.06	5.3e-08	-6.2	5.6	2.0e-08	0.04	0.08	0.92	FALSE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	FIG4	0.05	0.02	blup	92	0.02	1.0e-03	-6.0	5.6	2.7e-08	0.04	0.01	0.98	FALSE
22	GTEx	Breast Mammary Tissue	AK9	0.17	0.13	enet	19	0.13	4.0e-07	-6.2	5.5	4.0e-08	0.02	0.02	0.98	FALSE
72	The Cancer Genome Atlas	Colon Adenocarcinoma	SMPD2	0.17	0.14	lasso	4	0.14	2.3e-08	-5.1	-5.5	4.2e-08	0.02	0.11	0.89	FALSE
6	GTEx	Adipose Visceral Omentum	AK9	0.10	0.02	enet	27	0.04	2.7e-03	-6.1	5.5	4.3e-08	0.02	0.09	0.89	FALSE
65	YFS	Blood	CD164	0.03	0.01	blup	382	0.02	1.9e-07	4.2	-5.5	4.5e-08	0.01	0.98	0.02	FALSE
69	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SMPD2	0.04	0.04	blup	43	0.05	3.9e-05	-6.7	-5.5	4.9e-08	-0.01	0.02	0.97	FALSE
11	GTEx	Artery Coronary	SMPD2	0.11	0.09	lasso	4	0.07	1.9e-03	-4.7	-5.5	5.1e-08	0.02	0.07	0.81	FALSE
42	GTEx	Nerve Tibial	SMPD2	0.12	0.08	lasso	4	0.08	3.6e-06	-4.9	-5.4	5.4e-08	0.01	0.47	0.51	FALSE
10	GTEx	Artery Aorta	RP11-425D10.10	0.12	0.06	lasso	4	0.09	1.4e-05	-6.2	-5.4	7.0e-08	-0.05	0.04	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CD164	0.11	0.07	blup	376	0.10	1.6e-12	-5.1	5.3	1.1e-07	-0.02	0.06	0.94	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	SMPD2	0.11	0.06	lasso	6	0.06	4.1e-03	-4.7	-5.3	1.1e-07	0.01	0.07	0.80	FALSE
37	GTEx	Esophagus Muscularis	AK9	0.41	0.22	enet	60	0.29	5.7e-18	-6.3	5.3	1.2e-07	0.01	0.33	0.67	FALSE
19	GTEx	Brain Cerebellum	AK9	0.38	0.06	lasso	9	0.12	2.1e-04	-6.0	5.2	1.6e-07	0.03	0.15	0.29	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MICAL1	0.17	0.12	lasso	9	0.14	4.0e-17	-6.1	5.2	2.0e-07	-0.02	0.16	0.84	FALSE
3	GTEx	Adipose Subcutaneous	FIG4	0.12	0.08	lasso	4	0.07	4.4e-06	5.0	5.2	2.0e-07	0.02	0.92	0.05	FALSE
87	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AKD1	0.06	0.07	lasso	4	0.05	2.8e-06	-6.0	5.2	2.4e-07	0.02	0.23	0.77	FALSE