TWAS hub - RP1L1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0164	0.0087	0.0069	0.010	0.004	0.006	NA	0.009	3.2e-03	0.04400	1.4e-02	NA	0.00410
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0487	0.0312	0.0092	0.035	0.028	0.048	NA	0.032	6.8e-05	0.00039	3.8e-06	NA	0.00013

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Worrier / anxious feelings	23.0	43.4	72.8	-8.5	-3.8
Neuroticism score	18.6	38.8	57.8	-7.6	-4.5
Neuroticism (2016)	16.3	23.5	35.0	-5.9	-3.5
Nervous feelings	13.3	24.7	39.5	-6.3	-3.2
Irritability	13.0	21.9	32.9	-5.7	-3.3
Suffer from ‘nerves’	11.9	18.7	28.8	-5.4	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	11.5	26.4	49.4	7.0	1.8
High blood pressure	10.8	30.1	44.6	6.7	4.0
Heel bone mineral density (BMD) T-score, automated (left)	10.7	24.2	46.2	6.8	1.5
Hypertension (Self-reported)	10.5	29.3	44.5	6.7	3.7
Impedance of leg (left)	9.5	46.1	73.1	-8.6	-4.4
Tense / ‘highly strung’	9.5	15.8	20.7	-4.5	-3.3
Impedance of leg (right)	9.0	43.6	73.2	-8.6	-3.7
Vascular/heart problems diagnosed by doctor	8.9	24.3	37.2	-6.1	-3.4
Sensitivity / hurt feelings	8.6	14.7	26.0	-5.1	-1.8
Medication: Blood pressure	8.2	15.7	22.7	4.8	2.9
Miserableness	8.1	14.1	17.2	-4.2	-3.3
Impedance of whole body	7.9	40.1	69.5	-8.3	-3.3
Systolic blood pressure, automated reading	7.6	22.1	31.5	5.6	3.6
Comparative body size at age 10	7.2	20.0	37.9	6.2	1.4
Lupus	6.4	9.7	19.2	4.4	-0.4
Body mass index (BMI)	6.4	27.4	52.9	7.3	1.4
Osteoporosis (self-reported)	6.4	7.9	14.4	-3.8	-1.2
Guilty feelings	6.4	9.6	9.9	-3.0	-3.1
Average weekly beer plus cider intake	6.3	9.1	9.6	-3.1	-2.9
Diastolic blood pressure, automated reading	6.3	19.5	29.0	5.4	3.2
Medication: Bendroflumethiazide	6.1	9.3	15.4	3.9	1.8
Serious illness, injury or assault of a close relative in last 2 years	6.0	6.8	8.9	-3.0	-2.2
Body Mass Index (BMI) (2010)	5.9	8.1	14.1	3.8	1.5
Impedance of arm (right)	5.7	26.7	47.5	-6.9	-2.4
Fed-up feelings	5.6	10.2	12.3	-3.5	-2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	5.5	8.4	12.6	-3.6	-2.1
Type 2 Diabetes (T2D) (2012)	5.4	6.3	8.2	2.9	2.1
Worry too long after embarrassment	5.2	8.7	13.1	-3.6	-2.1
Impedance of arm (left)	4.9	22.8	42.4	-6.5	-1.8
Medication: Blood pressure	4.9	8.6	12.5	3.5	2.2
Ever depressed for a whole week	4.9	6.1	6.2	-2.5	-2.4
Age started oral contraceptive pill	4.6	5.8	7.7	-2.0	-2.8
Ever had stillbirth, spontaneous miscarriage or termination	4.5	4.8	8.7	2.9	0.9
Medication: Ramipril	4.4	5.6	6.2	2.5	2.3
Father’s age at death	4.4	5.9	10.1	-3.2	-1.3
Depression (self-reported)	4.3	5.2	6.1	-2.5	-2.0
Arm fat mass (right)	4.3	17.7	33.2	5.8	1.5
Mood swings	4.3	7.8	12.1	-3.5	-1.9
Supplements: Fish oil (including cod liver oil)	4.3	5.6	9.8	3.1	1.2
Leg fat-free mass (right)	4.2	22.4	36.3	6.0	2.9
Arm fat mass (left)	4.2	17.1	32.2	5.7	1.4
Frequency of depressed mood in last 2 weeks	4.1	5.7	6.4	-2.5	-2.2
Leg fat-free mass (left)	4.1	21.6	33.8	5.8	3.1
Overall health rating	4.1	8.8	17.1	4.1	0.8
Leg predicted mass (right)	4.1	22.1	35.5	6.0	2.9
Leg predicted mass (left)	4.0	21.4	34.1	5.8	3.0
Medication: Lisinopril	4.0	5.2	8.0	1.6	2.8
Risk taking	3.9	5.8	10.1	3.2	1.2
Tinnitus: Yes, but not now, but have in the past	3.8	4.1	4.9	1.8	2.2
Time employed in main current job	3.8	4.3	6.3	-2.5	-1.5
Prospective memory result	3.7	4.6	8.6	0.7	-2.9
Average weekly fortified wine intake	3.6	4.3	4.5	-2.1	-2.0
High blood pressure (mother)	3.6	5.1	7.3	1.7	2.7
Mouth/teeth dental problems: Loose teeth	3.6	4.3	7.7	2.8	0.9
Age at last live birth	3.6	5.3	8.8	-3.0	-1.3
Medication: Levothyroxine sodium	3.5	6.0	10.0	-3.2	-1.4
Mouth/teeth dental problems: Bleeding gums	3.5	4.5	7.9	2.8	1.1
Arm fat percentage (left)	3.5	13.8	26.8	5.2	0.9
Hip circumference	3.4	14.6	26.1	5.1	1.8
Illnesses of mother	3.4	4.2	8.4	-0.1	-2.9
Mother’s age at death	3.4	4.3	7.4	-2.7	-1.1
Weight	3.3	16.4	29.6	5.4	1.8
Leg fat mass (right)	3.3	12.9	25.4	5.0	0.6
Leg fat mass (left)	3.3	13.0	25.9	5.1	0.4
Arm fat percentage (right)	3.1	12.4	24.1	4.9	0.8
Hypothyroidism/myxoedema (self-reported)	3.1	6.0	10.8	-3.3	-1.1
Supplements: Vitamin C	3.1	3.7	4.9	2.2	1.6
Medication for cholesterol	3.1	4.7	6.7	-2.6	-1.6
Basal metabolic rate	3.1	17.2	27.9	5.3	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	5.8	1.1	2.4
Mineral and other dietary supplements	3.0	4.0	7.0	-2.6	-1.0
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	6.7	-2.6	-1.7
Whole body fat-free mass	2.9	16.5	25.6	5.1	2.7
Glaucoma (self-reported)	2.8	3.3	5.9	2.4	0.9
Arm predicted mass (right)	2.8	14.1	23.0	4.8	2.3
Whole body water mass	2.8	16.1	25.4	5.0	2.6
Health satisfaction	2.7	3.5	5.7	2.4	1.1
Whole body fat mass	2.7	11.5	22.6	4.8	0.6
Average weekly red wine intake	2.7	4.0	7.9	2.8	0.2
Eye problems/disorders: Glaucoma	2.7	3.2	5.4	2.3	1.0
Prostate Cancer	2.6	3.6	4.5	1.6	2.1
Ever unenthusiastic/disinterested for a whole week	2.6	3.1	6.2	-0.3	-2.5
Emphysema/chronic bronchitis	2.6	2.9	4.2	1.3	-2.1
Medication: Gliclazide	2.6	2.9	4.3	2.1	-1.2
Arm predicted mass (left)	2.6	13.1	24.1	4.9	1.5
Smoking status: Current	2.5	4.0	7.8	2.8	-0.4
Supplements: Zinc	2.4	2.7	3.0	1.7	1.5
Diabetes (mother)	2.4	3.0	4.7	2.2	1.1
Current tobacco smoking	2.4	3.9	7.6	2.8	-0.5
Alcohol usually taken with meals	2.4	3.8	4.5	1.8	2.1
Headache pain in last month	2.4	4.2	5.7	-2.4	-1.6
Arm fat-free mass (right)	2.4	12.2	20.8	4.6	1.9
Age at first live birth	2.4	4.3	8.6	-2.9	-0.2
Arm fat-free mass (left)	2.4	12.4	22.8	4.8	1.4
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	4.8	-0.4	-2.2
Mouth/teeth dental problems: Dentures	2.3	3.8	7.6	2.8	-0.3
Wheeze or whistling in the chest in last year	2.2	4.0	6.8	2.6	1.1
Leg fat percentage (left)	2.2	7.9	15.0	3.9	-0.9
Breast Cancer	2.1	5.0	9.9	3.1	0.4
Medication: Metformin	2.1	3.0	5.0	2.2	-1.0
Stomach or abdominal pain in last month	2.1	2.6	3.1	-1.8	-1.4
Trunk fat-free mass	2.1	12.0	16.6	4.1	2.7
Number of children fathered	2.1	2.4	4.7	2.2	-0.4
Triglycerides	2.0	3.4	6.4	-2.5	-0.6
Medication for hormone replacement therapy	2.0	2.2	2.6	1.4	1.6
Trunk fat mass	2.0	8.5	16.6	4.1	0.6
Mouth/teeth dental problems	2.0	3.0	6.0	-2.5	-0.0
Medication: Cholesterol lowering	2.0	3.1	4.2	1.4	2.0
Trunk predicted mass	2.0	11.7	16.5	4.1	2.6
Leg fat percentage (right)	2.0	7.2	14.0	3.7	-0.6
Medication: Ibuprofen	2.0	2.4	3.5	-1.1	-1.9
Medication: Aspirin	2.0	2.6	3.1	1.8	1.5
Medication: Aspirin	2.0	2.7	3.3	1.8	1.4
Average weekly champagne plus white wine intake	2.0	2.8	4.1	1.2	2.0
Commuting to job workplace: Public transport	2.0	2.3	4.0	-2.0	0.8
Ever highly irritable/argumentative for 2 days	1.9	2.3	3.7	-1.0	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	3.3	-1.1	-1.8
Fractured/broken bones in last 5 years	1.9	2.4	4.7	-0.4	-2.2
Alcohol drinker status: Previous	1.9	2.1	4.2	0.2	-2.1
HbA1C	1.8	2.0	3.2	1.8	0.9
Ever had hysterectomy (womb removed)	1.8	2.1	4.0	2.0	0.3
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	4.0	2.0	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	2.7	-1.4	-1.6
Bipolar Disorder or Schizophrenia	1.7	4.0	7.8	2.8	0.6
Loneliness, isolation	1.7	2.4	2.8	-1.7	-1.4
Body fat percentage	1.6	6.3	12.5	3.5	-0.3
Unable to work because of sickness or disability	1.6	2.1	3.3	1.8	-0.9
Crohns Disease (2017)	1.5	3.4	3.4	1.8	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	2.9	-1.0	-1.7
Medication: Atenolol	1.5	1.9	3.6	1.9	0.5
Breastfed as a baby	1.5	1.9	2.9	-1.7	-0.9
Smoking Status	1.4	3.4	6.6	-0.5	-2.6
Sitting height	1.4	10.1	13.0	2.7	3.6
Had menopause	1.4	1.7	2.9	0.7	-1.7
Exposure to tobacco smoke at home	1.4	1.5	1.6	1.2	1.3
Leg pain on walking	1.4	1.7	3.3	1.8	-0.2
Illnesses of father: High blood pressure	1.4	1.7	2.4	1.6	1.0
Schizophrenia (2018)	1.3	2.6	5.2	2.3	0.2
Worry (Nagel 2018)	1.3	2.7	5.2	-2.3	-0.6
Ovarian Cancer	1.3	1.7	2.1	1.5	1.1
Cardiovascular Disease	1.3	4.4	6.3	2.5	1.6
Hypothyroidism (self reported)	1.3	2.9	5.2	2.3	0.7
Number of treatments/medications taken	1.3	2.4	4.6	2.1	0.3
Vitamin and mineral supplements	1.3	1.8	3.6	-1.9	0.1
Noisy workplace	1.3	1.6	3.0	-1.7	-0.5
Asthma (self-reported)	1.3	2.6	4.0	2.0	1.1
High cholesterol (Self-reported)	1.3	2.3	4.3	2.1	0.5
Medication: Atorvastatin	1.3	1.7	2.8	0.7	1.7
Myopia	1.3	1.9	3.4	-1.8	-0.7
Birth weight of first child	1.2	2.2	3.9	-2.0	0.7
Pulse wave peak to peak time	1.2	1.4	2.7	-1.7	0.4
Medication: Allopurinol	1.2	1.6	3.3	-0.1	1.8
Medication: Omeprazole	1.2	1.4	2.8	1.7	0.1
Illnesses of siblings: Diabetes	1.2	1.4	1.9	1.0	1.4
Medication: Paracetamol	1.2	1.8	3.6	-0.0	-1.9
Schizophrenia (2014)	1.1	2.4	4.1	2.0	0.8
Lung FEV1/FVC ratio	1.1	5.5	9.5	3.1	1.2
Pack years adult smoking proportion	1.1	1.7	3.1	1.8	0.5
Trunk fat percentage	1.1	4.3	8.6	2.9	-0.1
Waist circumference	1.1	3.9	7.9	2.8	0.1
Qualifications: None of the above	1.1	2.3	4.6	-0.1	-2.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.8	-1.7	0.4
Family relationship satisfaction	1.1	1.3	1.5	-1.2	-1.1
Number of operations (self-reported)	1.1	1.6	2.7	1.6	0.8
Reaction Time	1.0	1.8	2.8	-1.7	-0.9
Hand grip strength (right)	1.0	2.7	3.9	2.0	1.2
Multivitamins +/- minerals	1.0	1.2	2.3	1.5	-0.4
Number of incorrect matches in round	1.0	1.6	2.5	-1.6	-0.9
Had other major operations	1.0	1.2	2.1	1.5	0.5
Allergy	1.0	2.2	2.7	-1.3	-1.6
Diabetes (self-reported)	1.0	1.6	2.5	1.6	0.8
Asthma	1.0	2.0	3.1	1.8	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	1.5	-1.1	-1.2
Qualifications: College or University degree	1.0	3.3	6.5	0.3	2.6
Heart disease (mother)	1.0	1.2	2.4	0.2	1.6
Smoking status: Previous	1.0	1.5	2.9	0.4	-1.7
Diabetes diagnosed by doctor	1.0	1.6	3.1	1.8	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	2.8	-1.7	-1.2
Bipolar Disorder (2018)	0.9	1.4	2.7	1.6	0.4
Schizophrenia vs Biploar Disorder	0.9	1.2	1.5	0.9	1.2
Systolic Blood Pressure	0.9	4.5	6.6	1.6	2.6
Hand grip strength (left)	0.9	2.4	4.5	2.1	0.6
Maternal smoking around birth	0.9	1.3	1.3	-1.1	-1.1
Age when periods started (menarche)	0.9	2.3	4.4	-2.1	-0.4
Medication: Simvastatin	0.9	1.3	2.4	1.6	0.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	2.2	-1.5	0.9
Number of full brothers	0.9	1.1	1.9	1.4	0.5
Shortness of breath walking on level ground	0.9	1.1	1.8	1.3	-0.7
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.9	0.2	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	2.6	-1.6	0.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	1.8	1.3	0.7
Irritable Bowel Disease (IBD)	0.8	1.8	2.7	1.0	1.6
Average weekly spirits intake	0.8	1.0	1.0	-1.0	-1.0
Hearing difficulty/problems: Yes	0.8	1.2	2.3	-1.5	0.1
Diabetes (father)	0.8	1.0	1.3	1.1	0.9
Severe depression (siblings)	0.8	0.9	1.6	0.3	-1.3
Past tobacco smoking	0.8	1.5	2.2	-1.5	0.9
Hair/balding pattern: Pattern 2	0.8	1.0	1.1	0.9	1.1
Pulse wave Arterial Stiffness index	0.8	1.0	1.9	1.4	-0.2
Length of working week for main job	0.8	0.9	1.2	1.1	0.8
Blood clot in the leg (DVT)	0.8	1.0	1.5	1.2	0.7
Medication: Paracetamol	0.8	1.3	2.4	-0.4	-1.6
Number of full sisters	0.8	1.0	1.5	1.2	0.7
Long-standing illness, disability or infirmity	0.8	1.2	1.6	1.3	-0.9
Ever had bowel cancer screening	0.8	0.9	1.5	-0.6	-1.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.1	-0.9	-1.0
Heart disease (siblings)	0.8	0.9	1.9	0.1	-1.4
Type 2 Diabetes (T2D) (2018)	0.7	1.2	1.6	1.3	0.9
Relative age of first facial hair	0.7	1.4	2.9	-1.7	0.1
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.1	0.1	1.8
Hair/balding pattern: Pattern 3	0.7	1.1	2.0	-1.4	-0.4
Peak expiratory flow (PEF)	0.7	1.7	3.1	-1.8	-0.6
Gout (self-reported)	0.7	0.9	1.7	-0.3	1.3
Medication: Ventolin 100micrograms inhaler	0.7	0.8	1.6	0.3	-1.3
Birth weight	0.7	1.6	2.6	0.7	1.6
High blood pressure (siblings)	0.7	1.0	1.9	-0.1	1.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.0	0.9	1.0
Ever taken oral contraceptive pill	0.7	0.7	0.8	-0.9	-0.8
Financial situation satisfaction	0.7	0.8	1.2	1.1	0.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	1.3	-0.1
Neuroticism (Nagel 2018)	0.6	1.4	1.8	-1.3	-1.0
Alzheimer’s Disease (in father)	0.6	0.6	0.8	0.7	-0.9
Mean Putamen Volume	0.6	0.7	1.2	0.5	1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	1.2	0.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.4	-0.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.5	-1.2	0.5
Fluid intelligence score	0.6	1.3	2.6	-1.6	0.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.0	-2.0	-0.5
Happiness	0.6	0.7	1.4	-0.2	-1.2
Standing height	0.6	5.8	10.4	-3.2	1.1
Commuting to job workplace: Cycle	0.6	0.8	1.2	1.1	-0.6
Pack years of smoking	0.6	0.9	1.7	1.3	0.3
Fasting Glucose	0.5	0.6	1.0	1.0	0.4
Allergy or Eczema	0.5	1.2	2.1	-0.6	1.4
Medication: Co-codamol	0.5	0.5	1.0	0.2	-1.0
Townsend deprivation index at recruitment	0.5	0.7	1.0	0.6	-1.0
Falls in the last year	0.5	0.7	1.0	0.7	-1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.0	-1.4	0.6
Lung cancer (father)	0.5	0.5	1.0	-1.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.0	-1.4	-1.1
Medication: Amlodipine	0.5	0.7	1.3	1.2	-0.0
Exposure to tobacco smoke outside home	0.5	0.7	0.9	0.9	-0.8
Migraine (self-reported)	0.5	0.6	1.0	-1.0	-0.5
Knee pain experienced in last month	0.5	0.8	1.1	0.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.9	-1.4	0.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.6	-0.7	0.8
Number of self-reported non-cancer illnesses	0.5	0.8	1.5	1.2	0.3
Depression (Nagel 2018)	0.4	0.6	1.0	1.0	-0.5
Age at First Birth	0.4	0.5	0.7	-0.6	-0.8
Primary Biliary Cirrhosis	0.4	0.6	1.1	1.1	0.2
BMI	0.4	2.4	4.2	2.1	-0.8
Relative age voice broke	0.4	0.6	0.7	-0.9	0.6
Qualifications: CSEs or equivalent	0.4	0.6	0.7	-0.7	0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.1	1.0	-0.2
Hearing difficulty/problems with background noise	0.4	0.7	1.3	-1.1	0.1
Forced vital capacity (FVC)	0.4	1.4	2.9	-1.7	0.0
Illnesses of siblings	0.4	0.6	1.1	-0.2	-1.0
Pulse rate	0.4	0.6	1.1	-1.1	0.4
Pulse wave reflection index	0.4	0.5	0.9	0.9	-0.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	-0.5	0.9
Qualifications: nursing, teaching	0.4	0.6	1.2	-1.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	1.0	-0.0
Supplements: Calcium	0.4	0.5	0.9	-1.0	-0.2
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	0.1	0.9
Depressed Affect (Nagel 2018)	0.3	0.6	0.8	-0.6	-0.9
Major Depression (MDD)	0.3	0.4	0.8	-0.1	-0.9
HDL Cholesterol	0.3	0.5	0.8	-0.3	-0.9
LDL Cholesterol	0.3	0.5	0.7	-0.8	-0.4
Blood White Count	0.3	2.1	3.5	-1.9	-0.8
Height	0.3	6.7	7.7	2.4	2.8
Chronotype (morning person)	0.3	0.6	0.9	-0.5	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	0.3	-0.9
Taking other prescription medications	0.3	0.5	0.6	0.8	0.6
Pain all over the body in last month	0.3	0.3	0.4	-0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	-1.0	-0.1
Hair/balding pattern: Pattern 4	0.3	0.8	1.5	0.3	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	-0.7	0.4
Eye problems/disorders: None of the above	0.3	0.3	0.5	-0.7	-0.5
Neck or shoulder pain in last month	0.3	0.4	0.8	-0.2	0.9
Medication: Seretide 50 evohaler	0.3	0.3	0.3	-0.6	-0.5
Commuting to job workplace: Walk	0.3	0.3	0.4	-0.4	0.6
Back pain experienced in last month	0.3	0.4	0.8	-0.2	-0.9
Breast cancer (self-reported)	0.3	0.4	0.6	0.8	0.5
Wears glasses or contact lenses	0.3	0.3	0.6	0.1	-0.8
Ever smoked	0.3	0.6	1.0	1.0	-0.3
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.1	-1.0	-0.0
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.0	0.7
Crohns Disease (2012)	0.2	0.3	0.5	0.7	0.3
Rheumatoid Arthritis	0.2	0.3	0.6	-0.8	-0.1
Heel T-Score	0.2	1.5	1.8	-1.4	-1.0
Waist Hip Ratio (WHR)	0.2	0.8	1.5	-1.2	-0.4
Neuroticism	0.2	0.5	0.7	-0.5	-0.9
Heart attack	0.2	0.2	0.4	-0.7	-0.1
Number of live births	0.2	0.3	0.3	-0.5	-0.5
Forced vital capacity (FVC), Best measure	0.2	0.8	1.0	-1.0	-0.8
Mean time to correctly identify matches	0.2	0.5	0.6	-0.8	-0.6
Illnesses of father: Heart disease	0.2	0.3	0.4	-0.7	-0.5
Hearing aid user	0.2	0.2	0.3	-0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	-0.8	-0.0
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.2	0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.1	0.4
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.5	0.4
Blood Red Count	0.1	1.2	2.4	0.2	-1.6
Lung FVC	0.1	0.7	1.5	-0.0	-1.2
Angina	0.1	0.1	0.2	-0.0	0.4
Financial difficulties in last 2 years	0.1	0.1	0.1	0.3	0.3
Medication: Lansoprazole	0.1	0.2	0.2	-0.4	-0.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.4	0.5
Alcohol intake frequency.	0.1	0.1	0.2	0.0	-0.5
Had major operations	0.1	0.1	0.2	-0.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.3	-0.5
Friendships satisfaction	0.1	0.1	0.2	0.4	-0.2
Eye problems/disorders: Cataract	0.1	0.2	0.2	-0.4	-0.4
Pain experienced in last month	0.1	0.1	0.2	0.3	0.4
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	-0.3	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	-0.0
Blood Eosinophil Count	0.0	0.3	0.3	-0.5	0.6
Blood Platelet Count	0.0	0.5	1.0	-1.0	0.2
Respiratory disease	0.0	0.0	0.1	0.3	0.1
Hair Pigment	0.0	0.3	0.4	-0.7	-0.3
Tanning	0.0	0.4	0.7	0.4	-0.9
Supplements: Glucosamine	0.0	0.0	0.0	0.0	0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.1	-0.2
Alcohol intake versus 10 years previously	0.0	0.1	0.1	0.4	0.0
Loud music exposure frequency	0.0	0.0	0.0	-0.2	0.0
Angina (self-reported)	0.0	0.1	0.1	0.1	0.3
Pulse rate, automated reading	0.0	0.1	0.2	0.0	-0.5
Comparative height size at age 10	0.0	0.0	0.0	-0.0	0.1
Chest pain or discomfort	0.0	0.0	0.1	-0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.2	-0.2
Osteoarthritis (self-reported)	0.0	0.0	0.0	0.2	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.1	0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.0	0.1
Alcohol drinker status: Never	0.0	0.1	0.1	-0.1	-0.3
Cholesterol lowering medication	0.0	0.1	0.1	0.0	-0.3

Hub : Genes

RP1L1

Models

Trait associations