[Hub]/) : Traits : Whole body fat-free mass : ← →

chr17:6,518,588-8,765,412

Best TWAS P=4.73e-15 · Best GWAS P=6.3e-18 conditioned to 4.99e-225

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Esophagus Mucosa	CHRNB1	0.19	0.11	lasso	2	0.13	7.3e-09	7.7	7.8	4.7e-15	0.29	0.80	0.20	TRUE
39	The Cancer Genome Atlas	Thyroid Carcinoma	SHBG	0.04	0.00	blup	59	0.02	4.4e-03	-3.8	-7.1	1.1e-12	-0.46	0.04	0.08	TRUE
25	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNB1	0.07	0.04	blup	57	0.05	1.6e-03	7.7	7.0	3.3e-12	0.34	0.00	0.87	TRUE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNB1	0.06	0.00	blup	57	0.03	4.5e-03	3.8	6.9	4.6e-12	0.34	0.00	0.76	TRUE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNB1	0.06	0.06	enet	10	0.06	1.0e-11	7.7	6.9	5.4e-12	0.32	0.00	1.00	TRUE
11	GTEx	Esophagus Mucosa	ZBTB4	0.12	0.10	lasso	2	0.08	8.0e-06	6.3	6.2	4.2e-10	0.26	0.96	0.00	TRUE
26	The Cancer Genome Atlas	Glioblastoma Multiforme	AMAC1L3	0.14	0.12	lasso	3	0.12	1.8e-04	6.0	-6.2	5.1e-10	-0.25	0.01	0.86	TRUE
8	GTEx	Breast Mammary Tissue (Male)	CHRNB1	0.28	-0.01	lasso	6	0.02	9.6e-02	7.7	6.2	7.7e-10	0.20	0.07	0.08	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EIF5A	0.20	0.12	bslmm	446	0.10	1.2e-12	-3.9	-6.1	9.8e-10	-0.05	1.00	0.00	TRUE
15	GTEx	Prostate	RP11-104H15.8	0.54	0.01	enet	1	0.06	1.6e-02	-5.8	-5.8	5.2e-09	-0.17	0.07	0.10	TRUE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALOXE3	0.04	0.00	blup	77	0.01	3.4e-02	-5.2	-5.7	1.2e-08	0.00	0.01	0.60	TRUE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EFNB3	0.07	0.04	blup	34	0.04	4.0e-05	-5.9	5.7	1.2e-08	0.34	0.16	0.07	TRUE
20	METSIM	Adipose	NEURL4	0.06	0.00	blup	454	0.01	8.2e-03	-0.8	-5.6	1.7e-08	-0.02	0.11	0.02	TRUE
14	GTEx	Pancreas	TRAPPC1	0.17	0.00	lasso	6	0.01	1.5e-01	6.2	5.2	1.8e-07	0.19	0.11	0.08	TRUE
4	GTEx	Adipose Visceral Omentum	CHRNB1	0.29	0.14	lasso	5	0.14	1.0e-07	7.7	7.7	1.3e-14	0.27	0.81	0.15	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	CHRNB1	0.17	0.15	lasso	3	0.16	7.4e-09	7.7	7.6	2.6e-14	0.29	0.88	0.12	FALSE
22	YFS	Blood	CHRNB1	0.04	0.02	lasso	5	0.04	8.5e-12	7.7	7.5	9.5e-14	0.31	0.78	0.22	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	CHRNB1	0.11	0.08	lasso	6	0.08	7.8e-11	7.7	7.2	5.6e-13	0.30	0.81	0.19	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	TNFSF12-TNFSF13	0.03	0.00	lasso	4	0.01	2.9e-02	-4.8	-7.2	7.9e-13	-0.45	0.01	0.66	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNB1	0.05	0.04	blup	57	0.04	6.1e-05	6.2	7.1	1.4e-12	0.23	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	SENP3	0.07	0.04	enet	9	0.03	2.7e-04	3.7	6.9	5.7e-12	0.20	0.12	0.74	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CHRNB1	0.09	0.06	lasso	2	0.08	9.8e-10	7.7	6.9	6.0e-12	0.16	0.74	0.26	FALSE
9	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	7.7	6.8	1.3e-11	0.46	0.84	0.16	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNB1	0.18	0.09	enet	10	0.10	4.9e-11	7.7	6.8	1.3e-11	0.30	0.00	1.00	FALSE
18	GTEx	Stomach	CHRNB1	0.28	0.19	lasso	4	0.23	2.0e-11	7.7	6.5	8.0e-11	0.15	0.78	0.20	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNB1	0.03	0.02	blup	57	0.02	7.8e-04	7.7	6.4	1.6e-10	0.36	0.00	0.99	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR2A	0.08	0.07	lasso	4	0.07	1.9e-08	6.1	6.3	2.3e-10	0.18	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNB1	0.09	0.02	blup	57	0.05	2.6e-05	-3.1	6.3	3.9e-10	0.23	0.10	0.77	FALSE
7	GTEx	Artery Tibial	TNFSF12	0.11	0.06	lasso	2	0.05	1.2e-04	6.2	6.2	4.3e-10	0.52	0.26	0.67	FALSE
12	GTEx	Esophagus Muscularis	ZBTB4	0.13	0.06	lasso	2	0.05	6.3e-04	6.2	6.2	4.7e-10	0.26	0.29	0.23	FALSE
19	GTEx	Whole Blood	TNFSF12	0.09	0.03	enet	24	0.04	1.9e-04	-4.8	-6.2	6.7e-10	-0.43	0.44	0.42	FALSE
17	GTEx	Skin Sun Exposed Lower leg	CHRNB1	0.19	0.12	enet	13	0.12	3.0e-10	6.3	6.1	8.2e-10	0.22	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNFSF12-TNFSF13	0.07	0.01	enet	17	0.03	4.4e-04	-4.8	-5.8	7.6e-09	-0.08	0.03	0.08	FALSE
23	YFS	Blood	TMEM107	0.17	0.17	lasso	5	0.19	2.0e-61	-5.3	-5.5	3.5e-08	-0.08	0.99	0.01	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNB1	0.06	0.07	lasso	6	0.07	1.8e-08	4.2	5.4	7.3e-08	0.28	0.53	0.47	FALSE
5	GTEx	Artery Aorta	CHRNB1	0.23	0.10	enet	7	0.13	1.3e-07	-2.8	5.4	8.1e-08	0.09	0.86	0.03	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	EFNB3	0.06	0.03	lasso	4	0.05	1.0e-05	-5.9	5.3	8.7e-08	0.19	0.91	0.00	FALSE
6	GTEx	Artery Tibial	CHRNB1	0.27	0.20	lasso	5	0.22	8.1e-17	-2.9	5.2	1.8e-07	0.08	1.00	0.00	FALSE
13	GTEx	Muscle Skeletal	EIF5A	0.14	0.06	enet	35	0.05	4.2e-06	-3.5	-5.2	2.4e-07	-0.02	0.96	0.00	FALSE