[Hub]/) : Traits : Whole body fat-free mass :

chr22:38,787,166-43,226,599

Best TWAS P=3.8e-10 · Best GWAS P=3.02e-15 conditioned to 1.05e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous CYP2D6 0.26 0.10 enet 34 0.20 1.2e-16 -3.8 -5.8 5.3e-09 0.45 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous MGAT3 0.08 0.04 lasso 4 0.04 4.3e-04 -5.8 5.5 3.7e-08 -0.07 0.02 0.98 FALSE
3 GTEx Artery Aorta APOBEC3G 0.40 0.40 lasso 3 0.39 6.3e-23 4.8 5.2 1.9e-07 0.07 0.67 0.32 FALSE
4 GTEx Brain Frontal Cortex BA9 SLC25A17 0.11 -0.01 lasso 5 0.00 3.5e-01 -4.2 -5.2 1.9e-07 0.22 0.07 0.20 FALSE
5 GTEx Breast Mammary Tissue (Female) POLR3H 0.09 -0.01 lasso 6 -0.01 6.4e-01 -5.3 5.6 2.3e-08 -0.46 0.04 0.06 FALSE
6 GTEx Breast Mammary Tissue (Female) DESI1 0.14 0.07 lasso 4 0.11 4.2e-04 -5.3 5.6 2.4e-08 -0.45 0.08 0.12 FALSE
7 GTEx Colon Sigmoid DESI1 0.21 0.08 enet 6 0.11 1.2e-04 -5.3 5.4 7.2e-08 -0.47 0.40 0.05 FALSE
8 GTEx Heart Atrial Appendage MGAT3 0.14 0.14 lasso 2 0.12 3.5e-06 -5.8 5.9 4.2e-09 -0.07 0.01 0.99 TRUE
9 GTEx Lung RP5-821D11.7 0.08 0.02 enet 21 0.04 6.6e-04 3.5 5.9 4.9e-09 -0.40 0.53 0.04 FALSE
10 GTEx Nerve Tibial SYNGR1 0.26 0.18 enet 27 0.21 3.6e-15 -4.6 -5.6 2.2e-08 0.05 0.06 0.93 FALSE
11 GTEx Pituitary APOBEC3G 0.34 0.04 enet 11 0.11 1.2e-03 4.8 5.6 1.8e-08 0.03 0.15 0.10 TRUE
12 GTEx Skin Sun Exposed Lower leg CENPM 0.05 0.00 enet 8 0.02 1.5e-02 -5.1 5.3 1.1e-07 -0.53 0.07 0.43 FALSE
13 GTEx Skin Sun Exposed Lower leg MGAT3 0.13 0.05 lasso 3 0.02 4.7e-03 -5.8 5.9 4.7e-09 -0.08 0.01 0.98 FALSE
14 GTEx Skin Sun Exposed Lower leg APOBEC3G 0.10 0.09 lasso 3 0.06 7.5e-06 4.8 5.1 3.0e-07 0.07 0.67 0.30 FALSE
15 GTEx Spleen CCDC134 0.23 0.00 enet 14 0.09 2.7e-03 -5.3 5.4 8.7e-08 -0.40 0.07 0.07 FALSE
16 GTEx Testis SREBF2 0.25 0.03 lasso 12 0.04 4.6e-03 4.1 5.2 2.4e-07 -0.41 0.62 0.04 FALSE
17 GTEx Vagina APOBEC3G 0.23 0.07 lasso 5 0.06 1.8e-02 4.7 5.3 1.3e-07 0.05 0.11 0.07 FALSE
18 NTR Blood SYNGR1 0.03 0.03 enet 6 0.03 1.0e-10 5.1 5.2 1.9e-07 0.08 0.47 0.53 FALSE
19 The Cancer Genome Atlas Breast Invasive Carcinoma TNRC6B 0.02 0.01 blup 92 0.01 2.7e-03 -4.7 -5.5 3.4e-08 0.12 0.02 0.77 FALSE
20 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma WBP2NL 0.06 0.04 blup 140 0.03 9.6e-05 -5.3 6.2 4.9e-10 -0.53 0.58 0.24 TRUE
21 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ADSL 0.04 0.03 enet 6 0.03 1.6e-04 -6.3 -5.6 2.3e-08 0.02 0.00 0.94 FALSE
22 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WBP2NL 0.10 0.04 blup 140 0.05 1.8e-06 -3.3 5.2 2.0e-07 -0.40 0.98 0.00 FALSE
23 The Cancer Genome Atlas Lung Adenocarcinoma ADSL 0.03 0.00 blup 33 0.01 8.9e-03 -6.1 -5.7 1.2e-08 0.06 0.01 0.61 FALSE
24 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ADSL 0.06 0.02 lasso 2 0.03 6.6e-03 -6.2 -6.2 6.6e-10 0.05 0.00 0.81 FALSE
25 The Cancer Genome Atlas Pancreatic Adenocarcinoma ADSL 0.09 0.03 lasso 3 0.01 7.7e-02 -6.3 -6.3 3.8e-10 0.11 0.00 0.76 TRUE