Best TWAS P=3.8e-10 · Best GWAS P=3.02e-15 conditioned to 1.05e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CYP2D6 | 0.26 | 0.10 | enet | 34 | 0.20 | 1.2e-16 | -3.8 | -5.8 | 5.3e-09 | 0.45 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | MGAT3 | 0.08 | 0.04 | lasso | 4 | 0.04 | 4.3e-04 | -5.8 | 5.5 | 3.7e-08 | -0.07 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Artery Aorta | APOBEC3G | 0.40 | 0.40 | lasso | 3 | 0.39 | 6.3e-23 | 4.8 | 5.2 | 1.9e-07 | 0.07 | 0.67 | 0.32 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | SLC25A17 | 0.11 | -0.01 | lasso | 5 | 0.00 | 3.5e-01 | -4.2 | -5.2 | 1.9e-07 | 0.22 | 0.07 | 0.20 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | POLR3H | 0.09 | -0.01 | lasso | 6 | -0.01 | 6.4e-01 | -5.3 | 5.6 | 2.3e-08 | -0.46 | 0.04 | 0.06 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | DESI1 | 0.14 | 0.07 | lasso | 4 | 0.11 | 4.2e-04 | -5.3 | 5.6 | 2.4e-08 | -0.45 | 0.08 | 0.12 | FALSE |
| 7 | GTEx | Colon Sigmoid | DESI1 | 0.21 | 0.08 | enet | 6 | 0.11 | 1.2e-04 | -5.3 | 5.4 | 7.2e-08 | -0.47 | 0.40 | 0.05 | FALSE |
| 8 | GTEx | Heart Atrial Appendage | MGAT3 | 0.14 | 0.14 | lasso | 2 | 0.12 | 3.5e-06 | -5.8 | 5.9 | 4.2e-09 | -0.07 | 0.01 | 0.99 | TRUE |
| 9 | GTEx | Lung | RP5-821D11.7 | 0.08 | 0.02 | enet | 21 | 0.04 | 6.6e-04 | 3.5 | 5.9 | 4.9e-09 | -0.40 | 0.53 | 0.04 | FALSE |
| 10 | GTEx | Nerve Tibial | SYNGR1 | 0.26 | 0.18 | enet | 27 | 0.21 | 3.6e-15 | -4.6 | -5.6 | 2.2e-08 | 0.05 | 0.06 | 0.93 | FALSE |
| 11 | GTEx | Pituitary | APOBEC3G | 0.34 | 0.04 | enet | 11 | 0.11 | 1.2e-03 | 4.8 | 5.6 | 1.8e-08 | 0.03 | 0.15 | 0.10 | TRUE |
| 12 | GTEx | Skin Sun Exposed Lower leg | CENPM | 0.05 | 0.00 | enet | 8 | 0.02 | 1.5e-02 | -5.1 | 5.3 | 1.1e-07 | -0.53 | 0.07 | 0.43 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | MGAT3 | 0.13 | 0.05 | lasso | 3 | 0.02 | 4.7e-03 | -5.8 | 5.9 | 4.7e-09 | -0.08 | 0.01 | 0.98 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | APOBEC3G | 0.10 | 0.09 | lasso | 3 | 0.06 | 7.5e-06 | 4.8 | 5.1 | 3.0e-07 | 0.07 | 0.67 | 0.30 | FALSE |
| 15 | GTEx | Spleen | CCDC134 | 0.23 | 0.00 | enet | 14 | 0.09 | 2.7e-03 | -5.3 | 5.4 | 8.7e-08 | -0.40 | 0.07 | 0.07 | FALSE |
| 16 | GTEx | Testis | SREBF2 | 0.25 | 0.03 | lasso | 12 | 0.04 | 4.6e-03 | 4.1 | 5.2 | 2.4e-07 | -0.41 | 0.62 | 0.04 | FALSE |
| 17 | GTEx | Vagina | APOBEC3G | 0.23 | 0.07 | lasso | 5 | 0.06 | 1.8e-02 | 4.7 | 5.3 | 1.3e-07 | 0.05 | 0.11 | 0.07 | FALSE |
| 18 | NTR | Blood | SYNGR1 | 0.03 | 0.03 | enet | 6 | 0.03 | 1.0e-10 | 5.1 | 5.2 | 1.9e-07 | 0.08 | 0.47 | 0.53 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TNRC6B | 0.02 | 0.01 | blup | 92 | 0.01 | 2.7e-03 | -4.7 | -5.5 | 3.4e-08 | 0.12 | 0.02 | 0.77 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | WBP2NL | 0.06 | 0.04 | blup | 140 | 0.03 | 9.6e-05 | -5.3 | 6.2 | 4.9e-10 | -0.53 | 0.58 | 0.24 | TRUE |
| 21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADSL | 0.04 | 0.03 | enet | 6 | 0.03 | 1.6e-04 | -6.3 | -5.6 | 2.3e-08 | 0.02 | 0.00 | 0.94 | FALSE |
| 22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | WBP2NL | 0.10 | 0.04 | blup | 140 | 0.05 | 1.8e-06 | -3.3 | 5.2 | 2.0e-07 | -0.40 | 0.98 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADSL | 0.03 | 0.00 | blup | 33 | 0.01 | 8.9e-03 | -6.1 | -5.7 | 1.2e-08 | 0.06 | 0.01 | 0.61 | FALSE |
| 24 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ADSL | 0.06 | 0.02 | lasso | 2 | 0.03 | 6.6e-03 | -6.2 | -6.2 | 6.6e-10 | 0.05 | 0.00 | 0.81 | FALSE |
| 25 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADSL | 0.09 | 0.03 | lasso | 3 | 0.01 | 7.7e-02 | -6.3 | -6.3 | 3.8e-10 | 0.11 | 0.00 | 0.76 | TRUE |