[Hub]/) : Traits : Basal metabolic rate : ← →

chr1:154,238,383-155,910,830

Best TWAS P=7.1e-38 · Best GWAS P=8.41e-35 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Skin Sun Exposed Lower leg	ADAM15	0.14	0.09	lasso	4	0.08	6.1e-07	12.31	-12.9	7.1e-38	-0.96	0.00	1.00	TRUE
3	GTEx	Brain Nucleus accumbens basal ganglia	DCST2	0.28	0.04	lasso	5	0.13	2.0e-04	12.31	7.7	1.1e-14	0.69	0.02	0.90	TRUE
19	ROSMAP	Brain Pre-frontal Cortex	SLC50A1	0.06	0.02	bslmm	331	0.03	4.3e-05	-6.96	-7.5	7.0e-14	-0.27	0.65	0.04	TRUE
7	GTEx	Esophagus Mucosa	MUC1	0.17	0.20	lasso	4	0.18	5.6e-12	-6.96	-6.7	1.8e-11	-0.12	1.00	0.00	TRUE
8	GTEx	Pancreas	THBS3	0.36	0.14	lasso	6	0.12	1.0e-05	3.15	-6.2	4.1e-10	-0.34	0.18	0.54	TRUE
16	GTEx	Vagina	GBAP1	0.27	0.08	lasso	7	0.17	1.3e-04	-5.75	5.6	2.2e-08	0.09	0.25	0.05	TRUE
15	GTEx	Thyroid	MUC1	0.11	0.02	enet	15	0.09	1.5e-07	4.89	5.4	7.7e-08	0.13	0.98	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	GBAP1	0.04	0.03	blup	337	0.03	8.6e-05	0.99	5.4	8.0e-08	0.05	0.88	0.00	TRUE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ADAM15	0.09	0.00	blup	49	0.02	3.6e-02	0.62	-5.2	1.7e-07	-0.43	0.01	0.09	TRUE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZBTB7B	0.05	0.06	lasso	2	0.05	1.8e-06	12.31	-12.3	9.3e-35	-1.00	0.00	1.00	FALSE
2	GTEx	Brain Cerebellar Hemisphere	DCST2	0.45	0.10	lasso	6	0.16	6.6e-05	-3.99	9.3	9.1e-21	0.75	0.01	0.96	FALSE
9	GTEx	Pancreas	RP11-263K19.4	0.22	0.06	enet	23	0.05	3.1e-03	3.15	-8.6	6.4e-18	-0.43	0.06	0.49	FALSE
18	NTR	Blood	ZBTB7B	0.02	0.02	lasso	1	0.01	5.4e-05	7.01	7.0	2.3e-12	0.67	0.87	0.03	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM46	0.03	0.00	blup	33	0.02	3.6e-03	-6.96	-6.5	8.1e-11	-0.11	0.01	0.67	FALSE
4	GTEx	Breast Mammary Tissue (Female)	FAM189B	0.05	-0.01	lasso	2	0.00	4.8e-01	-6.44	6.4	1.4e-10	0.09	0.04	0.07	FALSE
6	GTEx	Esophagus Mucosa	ADAM15	0.11	0.02	enet	16	0.04	1.5e-03	-5.82	-6.1	1.1e-09	-0.43	0.13	0.78	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	GBAP1	0.15	0.06	lasso	4	0.06	3.6e-04	-7.07	6.0	1.7e-09	0.11	0.54	0.04	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MUC1	0.04	0.01	enet	4	0.02	1.3e-03	-6.96	-6.0	1.8e-09	-0.15	0.00	0.87	FALSE
13	GTEx	Testis	MUC1	0.20	0.02	lasso	7	0.07	7.5e-04	-7.07	-6.0	1.9e-09	-0.11	0.27	0.05	FALSE
14	GTEx	Thyroid	DCST2	0.16	0.12	lasso	2	0.11	6.4e-09	-3.99	6.0	2.5e-09	0.53	0.38	0.62	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAG1AP1	0.07	0.00	blup	76	0.00	2.9e-01	-2.80	-5.8	5.0e-09	-0.17	0.02	0.26	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	LENEP	0.01	0.00	blup	37	0.01	1.6e-03	-3.71	5.8	8.5e-09	0.48	0.02	0.30	FALSE
17	METSIM	Adipose	DCST2	0.04	0.04	enet	12	0.04	4.3e-07	-4.17	5.8	9.1e-09	0.47	0.86	0.11	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	ADAM15	0.15	0.02	blup	49	0.08	1.4e-05	5.69	-5.7	1.3e-08	-0.34	0.03	0.04	FALSE
12	GTEx	Spleen	SHC1	0.22	0.14	lasso	2	0.08	4.0e-03	-5.75	-5.5	3.6e-08	-0.15	0.14	0.05	FALSE
5	GTEx	Colon Sigmoid	GBAP1	0.16	0.13	enet	8	0.14	8.4e-06	3.57	5.2	2.2e-07	0.09	0.65	0.04	FALSE