TWAS hub - SHC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.215	0.087	2.6e-03	0.141	NA	0.035	NA	0.082	1.9e-04	NA	0.04400	NA	4.0e-03
2	GTEx	Whole Blood	0.147	0.042	9.6e-05	0.077	NA	0.039	NA	0.055	1.4e-07	NA	0.00015	NA	8.3e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Mouth/teeth dental problems: Dentures	9.4	15.8	27.9	5.3	-1.9
Blood Red Count	7.6	73.7	106.1	6.4	-10.3
Impedance of leg (right)	7.0	33.7	58.4	7.6	-3.0
Impedance of leg (left)	7.0	34.2	56.1	7.5	-3.5
Smoking status: Previous	6.1	9.1	18.1	4.3	-0.2
Mouth/teeth dental problems	6.0	9.2	17.9	-4.2	0.7
Leg fat-free mass (right)	5.2	27.7	42.6	-6.5	3.6
Leg predicted mass (right)	5.2	27.7	42.2	-6.5	3.6
Breast Cancer	5.0	12.0	23.5	-4.8	0.7
Waist Hip Ratio (WHR)	4.9	21.9	26.0	4.2	-5.1
Leg fat-free mass (left)	4.8	25.5	36.7	-6.1	3.8
Leg predicted mass (left)	4.8	25.2	36.4	-6.0	3.8
Past tobacco smoking	4.6	8.4	16.2	-4.0	0.8
Medication: Allopurinol	4.3	5.8	11.3	-3.4	0.5
Medication: Gliclazide	4.2	4.7	7.7	2.8	1.3
Gout (self-reported)	4.1	5.7	11.4	-3.4	-0.0
Medication: Atorvastatin	3.9	4.8	6.6	2.6	-1.7
Allergy or Eczema	3.8	9.9	10.7	3.0	-3.3
Ever used hormone-replacement therapy (HRT)	3.7	4.7	6.5	-2.5	1.7
Supplements: Glucosamine	3.7	4.9	7.3	-2.7	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.6	4.3	6.1	2.5	1.6
Basal metabolic rate	3.5	19.4	30.4	-5.5	2.9
Whole body fat-free mass	3.4	19.2	29.9	-5.5	2.9
Whole body water mass	3.4	19.5	30.5	-5.5	2.9
Had major operations	3.3	3.8	5.3	1.5	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	3.2	7.3	8.9	-2.4	-3.0
High blood pressure (mother)	3.2	4.6	7.2	-2.7	1.4
Allergy	3.2	7.4	11.9	-3.5	1.7
Irritable Bowel Disease (IBD)	3.1	7.3	13.0	3.6	1.3
Eye problems/disorders: None of the above	3.1	3.6	6.4	-2.5	-0.9
Impedance of whole body	3.1	15.5	27.5	5.2	-1.9
Hayfever, allergic rhinitis or eczema	3.0	6.5	7.8	2.8	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	2.9	6.6	9.5	-1.9	-3.1
Eye problems/disorders: Cataract	2.9	3.3	3.8	1.7	2.0
Back pain experienced in last month	2.8	4.1	8.2	-2.9	-0.1
Ever smoked	2.8	4.9	5.7	2.4	-2.0
Hearing difficulty/problems: Yes	2.7	4.1	7.8	0.7	-2.8
Blood Platelet Count	2.6	29.8	59.4	7.7	-0.5
Trunk fat-free mass	2.6	14.8	25.0	-5.0	2.2
Trunk predicted mass	2.6	14.7	24.6	-5.0	2.2
Wears glasses or contact lenses	2.6	3.0	5.5	0.7	-2.3
Ulcerative Colitis (UC)	2.5	4.7	8.4	2.9	1.0
Coronary Artery Disease (CAD)	2.5	3.0	5.5	-0.7	2.3
Type 2 Diabetes (T2D) (2018)	2.5	4.7	8.1	2.8	-1.2
Diabetes (self-reported)	2.5	3.8	7.3	2.7	-0.5
Weight	2.5	12.5	20.9	-4.6	2.0
Hip circumference	2.5	10.7	12.6	-3.5	3.0
Pulse wave reflection index	2.5	3.0	3.5	1.6	-1.9
Emphysema/chronic bronchitis	2.5	2.8	4.5	2.1	1.0
Medication: Aspirin	2.5	3.3	5.1	2.3	-1.2
Commuting to job workplace: Public transport	2.5	3.0	4.5	-2.1	1.2
Depressed Affect (Nagel 2018)	2.4	5.1	10.1	3.2	0.3
Hearing difficulty/problems with background noise	2.4	3.8	5.2	1.6	-2.3
Happiness	2.4	2.9	5.0	2.2	1.0
Number of children fathered	2.4	2.7	3.0	-1.7	-1.5
Knee pain experienced in last month	2.4	3.8	7.6	-2.8	0.1
Crohns Disease (2012)	2.3	3.7	5.1	2.2	1.5
Miserableness	2.3	4.0	6.8	2.6	1.1
Ulcerative Colitis	2.2	3.2	4.0	2.0	1.6
Average weekly spirits intake	2.2	2.7	3.7	-1.3	-1.9
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	4.2	1.3	-2.0
Arm fat-free mass (left)	2.2	11.2	17.7	-4.2	2.2
Schizophrenia vs Biploar Disorder	2.1	2.8	5.5	-0.2	2.3
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	3.4	-1.8	1.4
Frequency of depressed mood in last 2 weeks	2.0	2.8	5.6	2.4	0.0
Arm predicted mass (right)	2.0	10.3	16.2	-4.0	2.1
Medication: Aspirin	2.0	2.6	4.7	2.2	-0.8
Illnesses of father: Heart disease	2.0	2.7	5.1	-2.3	0.6
Mood swings	2.0	3.5	6.7	2.6	0.6
Arm fat mass (left)	2.0	8.1	12.1	-3.5	2.0
Alcohol drinker status: Never	2.0	2.4	3.3	-1.8	1.2
Arm predicted mass (left)	2.0	10.0	15.6	-4.0	2.1
Major Depression (MDD)	1.9	2.4	4.2	0.7	2.0
Body Mass Index (BMI) (2010)	1.9	2.6	4.6	-2.1	0.7
Heel T-Score	1.9	15.2	18.3	-4.3	-3.5
Pulse wave peak to peak time	1.9	2.3	3.1	-1.2	1.8
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.7	0.4	-2.2
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	4.8	2.2	-0.2
Crohns Disease (2017)	1.8	4.0	6.8	2.6	1.1
Medication for hormone replacement therapy	1.8	2.0	4.0	-2.0	-0.3
Medication: Metformin	1.8	2.6	4.8	2.2	-0.6
Fed-up feelings	1.8	3.4	6.4	2.5	0.5
Arm fat mass (right)	1.8	7.3	11.9	-3.4	1.7
Breastfed as a baby	1.8	2.2	4.4	0.0	-2.1
Blood clot in the leg (DVT)	1.8	2.4	4.7	2.2	0.1
Osteoporosis (self-reported)	1.8	2.3	2.5	1.4	1.6
Pain experienced in last month	1.8	3.0	6.0	2.5	0.2
Alzheimer’s Disease (in father)	1.7	1.9	3.1	-1.8	0.8
Stomach or abdominal pain in last month	1.7	2.1	2.6	1.2	-1.6
Arm fat-free mass (right)	1.7	8.7	13.3	-3.6	2.0
Diabetes diagnosed by doctor	1.7	2.7	5.4	2.3	0.1
Prostate Cancer	1.6	2.3	2.4	1.5	-1.5
Serious illness, injury or assault to yourself	1.6	1.9	3.5	0.6	1.9
Pulse wave Arterial Stiffness index	1.6	1.9	2.7	1.0	-1.6
Risk taking	1.6	2.4	3.1	1.7	-1.3
Depression (Nagel 2018)	1.5	2.2	4.3	2.1	0.2
Neuroticism	1.5	3.6	7.0	2.6	-0.3
Body mass index (BMI)	1.5	6.3	11.0	-3.3	1.3
Medication: Cholesterol lowering	1.5	2.4	4.7	2.2	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.9	7.2	-2.7	1.6
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.7	1.7	1.1
Birth weight	1.5	3.2	5.8	-0.8	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	1.8	-1.3	-1.4
Mean Putamen Volume	1.4	1.5	1.6	1.3	-1.2
Lung FVC	1.4	7.3	12.8	-3.6	1.3
Multivitamins +/- minerals	1.4	1.7	2.7	-1.6	0.9
Illnesses of mother	1.4	1.7	2.6	0.9	-1.6
Unable to work because of sickness or disability	1.4	1.8	3.5	0.1	1.9
Supplements: Calcium	1.4	1.5	3.0	1.7	0.3
Reaction Time	1.3	2.4	4.0	-0.9	2.0
Forced vital capacity (FVC)	1.3	4.9	8.6	-2.9	1.1
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	7.8	-2.8	1.0
Asthma	1.3	2.6	3.2	1.8	-1.4
Prospective memory result	1.3	1.6	2.0	-1.4	1.1
Forced vital capacity (FVC), Best measure	1.3	4.6	7.1	-2.7	1.4
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.0	0.1	-1.7
High cholesterol (Self-reported)	1.3	2.3	4.2	2.1	-0.6
Neuroticism (Nagel 2018)	1.2	2.7	5.1	2.3	0.6
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.8	-1.7	0.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.8	0.9	-1.4
Medication: Lansoprazole	1.2	1.4	2.0	1.4	0.9
Birth weight of first child	1.2	2.2	4.2	-0.6	2.0
Peak expiratory flow (PEF)	1.2	2.7	3.5	-1.9	-1.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	1.8	1.3	1.1
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.0	-2.0	-0.1
Number of full sisters	1.2	1.4	2.3	-1.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	3.2	-1.8	1.3
Mineral and other dietary supplements	1.2	1.6	1.6	1.3	-1.3
Osteoarthritis (self-reported)	1.2	1.5	2.3	-0.9	-1.5
Number of self-reported non-cancer illnesses	1.2	2.2	3.5	0.9	-1.9
Ever had prostate specific antigen (PSA) test	1.2	1.4	1.7	-1.1	-1.3
LDL Cholesterol	1.1	1.8	3.6	1.9	-0.0
Height	1.1	22.0	34.2	-5.8	3.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.0	-0.7	1.4
Qualifications: CSEs or equivalent	1.1	1.5	2.8	-0.4	1.7
Exposure to tobacco smoke outside home	1.1	1.5	2.1	1.0	-1.4
Medication: Ibuprofen	1.1	1.3	2.5	-1.6	0.4
Illnesses of siblings: Diabetes	1.1	1.3	2.5	-1.6	0.3
Irritability	1.1	1.9	2.9	1.7	0.9
Bipolar Disorder (2018)	1.0	1.6	2.5	1.6	-0.8
Tanning	1.0	12.7	22.7	1.6	-4.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	2.5	1.6	-0.5
Leg pain on walking	1.0	1.2	1.7	-1.3	0.9
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.8	-0.7	1.4
Commuting to job workplace: Walk	1.0	1.0	1.9	-1.4	0.5
Financial situation satisfaction	1.0	1.2	2.2	1.5	-0.4
Blood Eosinophil Count	0.9	6.6	10.4	1.7	-3.2
Systolic blood pressure, automated reading	0.9	2.6	3.0	-1.7	-1.5
Illnesses of siblings	0.9	1.3	2.4	1.5	-0.5
Loud music exposure frequency	0.9	1.0	1.5	-0.7	1.2
Wheeze or whistling in the chest in last year	0.9	1.5	3.1	1.8	-0.2
Whole body fat mass	0.9	3.6	5.6	-2.4	1.3
Family relationship satisfaction	0.9	1.2	2.3	1.5	-0.2
Arm fat percentage (left)	0.9	3.6	5.8	-2.4	1.2
Breast cancer (self-reported)	0.9	1.0	2.1	-0.1	-1.4
Asthma (self-reported)	0.9	1.7	2.4	1.6	-1.0
Medication: Paracetamol	0.9	1.4	2.8	-0.2	1.7
Commuting to job workplace: Cycle	0.9	1.1	1.2	1.0	1.1
Smoking Status	0.8	2.0	3.4	1.9	-0.8
Medication: Levothyroxine sodium	0.8	1.4	2.8	-0.0	1.7
Trunk fat mass	0.8	3.4	5.3	-2.3	1.2
Pain all over the body in last month	0.8	0.8	1.5	-0.4	1.2
Neuroticism score	0.8	1.6	2.9	1.7	0.6
Arm fat percentage (right)	0.8	3.0	4.6	-2.2	1.2
Hair/balding pattern: Pattern 4	0.8	1.9	3.2	-1.8	-0.7
Medication: Amlodipine	0.8	1.1	1.7	1.3	0.7
Chest pain or discomfort	0.8	1.2	2.1	1.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.1	1.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.3	1.1	-0.8
Loneliness, isolation	0.8	1.1	2.2	1.5	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.0	1.0	-0.9
Illnesses of father: None of the above (group 1)	0.8	1.0	1.4	1.2	-0.7
Illnesses of father: High blood pressure	0.8	1.0	1.8	-0.3	1.4
HbA1C	0.7	0.8	1.2	1.1	0.6
Lupus	0.7	1.0	2.0	-0.2	-1.4
Blood White Count	0.7	5.4	10.0	3.2	-0.9
BMI	0.7	4.2	8.3	-2.9	0.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.6	0.6	1.2
Average weekly fortified wine intake	0.7	0.9	1.1	-0.8	1.1
Financial difficulties in last 2 years	0.7	0.9	1.8	-0.2	-1.4
Impedance of arm (right)	0.7	3.4	6.8	2.6	-0.1
Father’s age at death	0.7	0.9	1.5	1.2	-0.6
Noisy workplace	0.7	0.8	1.0	1.0	0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.4	-0.9	-1.2
Medication: Blood pressure	0.7	1.2	2.1	1.4	-0.6
Medication: Omeprazole	0.7	0.8	1.3	1.1	-0.6
Mother’s age at death	0.7	0.9	1.4	0.6	-1.2
Eye problems/disorders: Glaucoma	0.7	0.8	1.1	0.7	-1.1
Diastolic blood pressure, automated reading	0.7	2.0	3.9	-2.0	-0.5
Cholesterol lowering medication	0.7	1.0	1.6	0.7	-1.2
Alzheimer’s Disease (including proxy)	0.6	0.9	1.7	-1.3	0.2
Age at First Birth	0.6	0.8	0.9	-0.9	0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	0.3	-1.1
Hypothyroidism (self reported)	0.6	1.4	2.2	-1.5	0.7
Respiratory disease	0.6	1.3	1.4	1.2	-1.1
Vitamin and mineral supplements	0.6	0.8	1.1	1.1	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	1.2	0.1
Age when periods started (menarche)	0.6	1.5	2.1	1.5	0.9
Medication: Atenolol	0.6	0.7	1.4	-1.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	0.9	0.7	1.0
Medication: Ramipril	0.6	0.8	1.5	1.2	-0.4
Number of live births	0.6	0.9	1.8	1.3	0.2
Impedance of arm (left)	0.6	2.7	5.5	2.3	-0.1
Glaucoma (self-reported)	0.6	0.7	0.8	0.7	-0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	1.9	-1.4	0.8
High blood pressure (siblings)	0.6	0.9	1.4	-1.2	0.6
Worry too long after embarrassment	0.6	1.0	2.0	1.4	0.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.2	1.1	-0.5
Alcohol intake frequency.	0.6	1.5	2.9	-0.3	1.7
Overall health rating	0.6	1.2	2.0	0.7	1.4
Age at last live birth	0.6	0.9	0.9	1.0	0.9
Supplements: Vitamin C	0.6	0.7	1.4	1.2	0.1
Average weekly champagne plus white wine intake	0.6	0.9	1.6	-1.3	-0.3
Hearing aid user	0.6	0.6	1.2	0.3	-1.1
Neuroticism (2016)	0.5	0.7	1.0	0.7	1.0
Primary Biliary Cirrhosis	0.5	0.7	1.3	-0.5	1.1
Hair Pigment	0.5	12.9	25.7	5.1	0.1
Relative age of first facial hair	0.5	1.1	2.2	-0.1	-1.5
Sitting height	0.5	3.9	7.7	-0.3	2.8
Time employed in main current job	0.5	0.6	0.6	-0.8	-0.8
Falls in the last year	0.5	0.7	1.0	-0.6	1.0
Standing height	0.5	5.4	8.4	-2.9	1.6
Ever depressed for a whole week	0.5	0.6	0.9	0.6	-1.0
Leg fat mass (left)	0.5	1.9	3.0	-1.7	0.9
Ovarian Cancer	0.4	0.6	0.7	0.7	-0.8
Systolic Blood Pressure	0.4	1.8	3.6	0.2	-1.9
Sensitivity / hurt feelings	0.4	0.7	1.1	1.0	-0.5
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	-0.9	0.2
Diabetes (father)	0.4	0.6	1.1	-1.0	-0.1
Pack years adult smoking proportion	0.4	0.5	0.9	-0.5	0.9
Hand grip strength (right)	0.4	1.1	1.5	-0.9	-1.2
Alcohol intake versus 10 years previously	0.4	0.6	1.2	-0.1	1.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	1.1	0.2
Depression (self-reported)	0.4	0.5	1.1	1.0	0.1
Lung cancer (father)	0.4	0.5	1.0	1.0	-0.1
Exposure to tobacco smoke at home	0.4	0.4	0.6	0.4	0.8
Tense / ‘highly strung’	0.4	0.7	1.3	1.1	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.8	-0.9	0.4
Migraine (self-reported)	0.4	0.4	0.8	0.2	0.9
Leg fat mass (right)	0.4	1.6	2.3	-1.5	0.9
Comparative height size at age 10	0.4	2.3	3.1	-1.8	1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.1	-0.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.6	-1.3	-0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.6	-0.6	0.8
Fractured/broken bones in last 5 years	0.4	0.6	1.0	0.4	1.0
Alcohol drinker status: Previous	0.4	0.4	0.8	0.3	-0.9
Bipolar Disorder or Schizophrenia	0.3	0.7	1.1	1.0	-0.6
Worry (Nagel 2018)	0.3	0.7	1.4	-0.0	1.2
HDL Cholesterol	0.3	0.4	0.9	-0.0	-0.9
Rheumatoid Arthritis	0.3	0.4	0.5	0.7	-0.7
Chronotype (morning person)	0.3	0.8	0.8	0.9	-0.9
Angina	0.3	0.3	0.4	0.6	-0.6
Waist circumference	0.3	0.9	1.6	-1.3	0.4
Number of incorrect matches in round	0.3	0.4	0.7	-0.8	-0.4
Alcohol usually taken with meals	0.3	0.5	0.5	0.6	0.7
Had other major operations	0.3	0.3	0.7	-0.8	-0.1
Qualifications: None of the above	0.3	0.6	1.2	0.1	1.1
Heart attack	0.3	0.4	0.5	0.7	0.5
Medication: Simvastatin	0.3	0.4	0.8	0.9	0.2
Medication: Paracetamol	0.3	0.4	0.6	-0.6	0.8
Health satisfaction	0.3	0.3	0.6	-0.2	0.8
Shortness of breath walking on level ground	0.3	0.4	0.8	0.2	0.9
Medication: Seretide 50 evohaler	0.3	0.4	0.6	0.8	-0.3
Suffer from ‘nerves’	0.3	0.5	0.8	-0.4	0.9
Guilty feelings	0.3	0.4	0.4	-0.6	-0.7
Medication: Bendroflumethiazide	0.3	0.5	0.9	0.0	-1.0
Age started oral contraceptive pill	0.3	0.3	0.6	0.2	0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.9	0.0
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.3	-0.8
Fasting Glucose	0.2	0.2	0.4	0.0	0.6
Cardiovascular Disease	0.2	0.5	0.8	0.4	-0.9
Lung FEV1/FVC ratio	0.2	0.9	1.1	1.1	-0.8
Hand grip strength (left)	0.2	0.4	0.5	-0.6	-0.7
Number of treatments/medications taken	0.2	0.3	0.4	0.6	-0.5
Supplements: Zinc	0.2	0.2	0.3	0.3	0.6
Medication: Co-codamol	0.2	0.2	0.4	-0.2	0.6
Diabetes (mother)	0.2	0.3	0.4	0.3	0.7
Severe depression (siblings)	0.2	0.2	0.3	0.5	-0.4
Trunk fat percentage	0.2	0.7	1.0	-1.0	0.7
Townsend deprivation index at recruitment	0.2	0.4	0.7	0.8	-0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.4	-0.7	-0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.2	0.4	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.8	-0.1
Had menopause	0.2	0.2	0.4	0.2	0.6
Fluid intelligence score	0.2	0.4	0.5	-0.7	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.3	0.5	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.1	0.6
Length of working week for main job	0.2	0.3	0.5	0.7	-0.1
Age at first live birth	0.2	0.4	0.6	0.5	0.7
Angina (self-reported)	0.2	0.3	0.4	0.5	-0.6
Mean time to correctly identify matches	0.2	0.4	0.7	0.2	0.9
Pulse rate, automated reading	0.2	0.5	0.5	0.7	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	0.6	-0.4
Average weekly red wine intake	0.2	0.2	0.3	0.4	-0.6
Medication for cholesterol	0.2	0.4	0.5	0.7	0.5
Ever taken oral contraceptive pill	0.2	0.3	0.5	-0.1	0.7
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.0	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.6	0.2
Schizophrenia (2014)	0.1	0.2	0.3	-0.3	0.6
Current tobacco smoking	0.1	0.1	0.1	-0.3	-0.3
Maternal smoking around birth	0.1	0.1	0.2	-0.4	-0.3
Nervous feelings	0.1	0.2	0.5	-0.7	0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.5	0.1
Pulse rate	0.1	0.2	0.4	0.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.2	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	-0.2
Headache pain in last month	0.1	0.2	0.3	0.6	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.5	-0.0
Body fat percentage	0.1	0.3	0.4	-0.6	0.5
Comparative body size at age 10	0.1	0.4	0.6	-0.8	-0.4
Qualifications: College or University degree	0.1	0.5	0.9	-0.2	-0.9
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.4	0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.6	-0.3
Friendships satisfaction	0.1	0.1	0.2	-0.0	-0.4
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.5	0.0
Smoking status: Current	0.1	0.2	0.4	-0.2	-0.6
Medication: Blood pressure	0.1	0.2	0.3	-0.6	0.3
Leg fat percentage (left)	0.1	0.2	0.4	0.2	-0.7
Number of operations (self-reported)	0.1	0.1	0.2	0.5	-0.1
Myopia	0.1	0.1	0.2	-0.2	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.5	0.2
Heart disease (siblings)	0.1	0.1	0.3	-0.5	0.1
Pack years of smoking	0.1	0.2	0.3	0.1	0.5
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	-0.0	0.2
Schizophrenia (2018)	0.0	0.0	0.0	0.0	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	-0.1	0.2
Relative age voice broke	0.0	0.0	0.0	0.0	0.1
Taking other prescription medications	0.0	0.0	0.0	0.1	0.1
High blood pressure	0.0	0.0	0.1	-0.3	-0.1
Worrier / anxious feelings	0.0	0.0	0.0	0.2	0.0
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.3	0.1
Leg fat percentage (right)	0.0	0.2	0.2	0.3	-0.5
Number of full brothers	0.0	0.1	0.1	-0.2	0.2
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.2	0.1
Heart disease (mother)	0.0	0.0	0.1	-0.0	0.3
Hypertension (Self-reported)	0.0	0.0	0.1	-0.0	-0.3
Ever had bowel cancer screening	0.0	0.0	0.0	-0.1	-0.2
Medication: Lisinopril	0.0	0.0	0.1	-0.2	0.1
Average weekly beer plus cider intake	0.0	0.0	0.1	0.3	0.0
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.1	-0.1	0.3

Hub : Genes

SHC1

Models

Trait associations